olanzapine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
psychoactive 1982 132539-06-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • olanzapine pamoate
  • olanzapine embonate
  • zyprexa relprevv
  • olanzapine pamoate monohydrate
  • olanzapine
  • zyprexa
  • LY 170053
  • LY-170053
The mechanism of action of olanzapine, as with other drugs having efficacy in schizophrenia, is unknown. However, it has been proposed that this drug’s efficacy in schizophrenia is mediated through a combination of dopamine and serotonin type 2 (5HT2) antagonism. The mechanism of action of olanzapine in the treatment of acute manic or mixed episodes associated with bipolar I disorder is unknown.
  • Molecular weight: 312.44
  • Formula: C17H20N4S
  • CLOGP: 2.86
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 30.87
  • ALOGS: -3.52
  • ROTB: 0

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O
10 mg P
10 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 7 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.69 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Sept. 30, 1996 FDA LILLY

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Weight increased 1896.08 33.39 641 9234 21696 2326514
Toxicity to various agents 1674.31 33.39 646 9229 32108 2316102
Neuroleptic malignant syndrome 1643.61 33.39 350 9525 1730 2346480
Overdose 1353.06 33.39 485 9390 19422 2328788
Completed suicide 1286.00 33.39 474 9401 20560 2327650
Suicide attempt 1273.94 33.39 403 9472 10879 2337331
Electrocardiogram QT prolonged 1096.43 33.39 330 9545 7484 2340726
Intentional overdose 1092.02 33.39 359 9516 10962 2337248
Somnolence 1009.33 33.39 410 9465 23075 2325135
Diabetes mellitus 976.16 33.39 299 9576 7196 2341014
Sedation 940.39 33.39 244 9631 3118 2345092
Agitation 842.71 33.39 294 9581 10757 2337453
Psychotic disorder 797.51 33.39 230 9645 4449 2343761
Exposure during pregnancy 792.83 33.39 353 9522 24866 2323344
Coma 776.04 33.39 263 9612 8793 2339417
Drug abuse 769.62 33.39 281 9594 11745 2336465
Sopor 755.49 33.39 213 9662 3782 2344428
Drug interaction 731.45 33.39 349 9526 28814 2319396
Confusional state 711.58 33.39 324 9551 24020 2324190
Extrapyramidal disorder 615.62 33.39 162 9713 2185 2346025
Intentional self-injury 585.10 33.39 176 9699 3951 2344259
Tachycardia 564.20 33.39 245 9630 16164 2332046
Akathisia 553.55 33.39 139 9736 1535 2346675
Drug ineffective 550.01 33.39 458 9417 101166 2247044
Neutropenia 533.64 33.39 256 9619 21292 2326918
Hypothermia 528.65 33.39 141 9734 2007 2346203
Fall 518.03 33.39 327 9548 46772 2301438
Parkinsonism 487.80 33.39 123 9752 1382 2346828
Catatonia 486.44 33.39 110 9765 740 2347470
Schizophrenia 480.06 33.39 119 9756 1240 2346970
Prescribed overdose 469.11 33.39 124 9751 1700 2346510
Off label use 459.06 33.39 361 9514 73237 2274973
Condition aggravated 454.45 33.39 262 9613 31717 2316493
Depressed level of consciousness 446.37 33.39 167 9708 7437 2340773
Tremor 444.18 33.39 223 9652 20438 2327772
Leukopenia 439.63 33.39 179 9696 10017 2338193
Cardio-respiratory arrest 430.34 33.39 171 9704 8975 2339235
Pulmonary embolism 426.72 33.39 208 9667 17875 2330335
Suicidal ideation 425.14 33.39 179 9696 10908 2337302
Dystonia 409.92 33.39 116 9759 2078 2346132
Treatment noncompliance 408.57 33.39 144 9731 5390 2342820
Delusion 407.71 33.39 114 9761 1951 2346259
Type 2 diabetes mellitus 405.39 33.39 115 9760 2079 2346131
Rhabdomyolysis 399.86 33.39 149 9726 6555 2341655
Delirium 389.74 33.39 137 9738 5086 2343124
Blood glucose increased 388.01 33.39 173 9702 12117 2336093
Anxiety 383.79 33.39 228 9647 29131 2319079
Dyskinesia 378.01 33.39 131 9744 4658 2343552
Hallucination 375.09 33.39 150 9725 7998 2340212
Muscle rigidity 374.82 33.39 104 9771 1727 2346483
Mania 371.35 33.39 110 9765 2330 2345880
Alanine aminotransferase increased 362.99 33.39 172 9703 13860 2334350
Hypotension 355.26 33.39 225 9650 32211 2315999
Hyponatraemia 349.76 33.39 165 9710 13160 2335050
Depression 345.64 33.39 210 9665 27922 2320288
Pneumonia aspiration 344.88 33.39 115 9760 3627 2344583
Gestational diabetes 340.91 33.39 91 9784 1296 2346914
Tardive dyskinesia 336.02 33.39 94 9781 1610 2346600
Cardiac arrest 334.88 33.39 166 9709 14764 2333446
Loss of consciousness 332.46 33.39 178 9697 18589 2329621
Miosis 328.00 33.39 86 9789 1138 2347072
Seizure 324.75 33.39 192 9683 24274 2323936
Blood triglycerides increased 310.49 33.39 94 9781 2149 2346061
White blood cell count decreased 309.36 33.39 168 9707 18040 2330170
Hallucination, auditory 308.31 33.39 93 9782 2099 2346111
Blood creatine phosphokinase increased 294.65 33.39 111 9764 5025 2343185
Hyperprolactinaemia 289.30 33.39 70 9805 652 2347558
Abnormal behaviour 288.11 33.39 107 9768 4653 2343557
Aggression 287.54 33.39 107 9768 4679 2343531
Insomnia 282.39 33.39 179 9696 25608 2322602
Restlessness 281.42 33.39 104 9771 4459 2343751
Dysarthria 279.48 33.39 113 9762 6189 2342021
Psychomotor hyperactivity 276.57 33.39 83 9792 1839 2346371
Hyperglycaemia 274.51 33.39 104 9771 4781 2343429
Aspartate aminotransferase increased 273.17 33.39 137 9738 12475 2335735
Blood cholesterol increased 253.29 33.39 100 9775 5141 2343069
Disorientation 247.73 33.39 104 9771 6268 2341942
Respiratory depression 245.78 33.39 78 9797 2092 2346118
Respiratory arrest 240.73 33.39 101 9774 6077 2342133
Pyrexia 239.93 33.39 218 9657 53490 2294720
Post-injection delirium sedation syndrome 239.89 33.39 38 9837 6 2348204
Salivary hypersecretion 234.29 33.39 66 9809 1159 2347051
Pneumonia 225.83 33.39 203 9672 49093 2299117
Metabolic disorder 217.55 33.39 54 9821 564 2347646
Blood prolactin abnormal 211.52 33.39 39 9836 71 2348139
Hypertension 211.15 33.39 153 9722 27208 2321002
Hospitalisation 205.83 33.39 120 9755 14733 2333477
White blood cell count increased 205.24 33.39 94 9781 6984 2341226
Oedema peripheral 199.71 33.39 140 9735 23623 2324587
Serotonin syndrome 197.51 33.39 75 9800 3465 2344745
Blood prolactin increased 197.32 33.39 56 9819 1011 2347199
Generalised tonic-clonic seizure 193.23 33.39 83 9792 5289 2342921
Sexual dysfunction 190.04 33.39 43 9832 289 2347921
Persecutory delusion 187.94 33.39 46 9829 451 2347759
Cardiometabolic syndrome 186.17 33.39 40 9835 204 2348006
Dysphagia 184.15 33.39 106 9769 12699 2335511
Gamma-glutamyltransferase increased 183.96 33.39 81 9794 5481 2342729
Constipation 183.05 33.39 128 9747 21501 2326709
Intentional product misuse 181.92 33.39 95 9780 9394 2338816
Dizziness 181.52 33.39 195 9680 58470 2289740
Gait disturbance 180.56 33.39 129 9746 22416 2325794
Mental disorder 178.08 33.39 72 9803 3935 2344275
Obesity 177.18 33.39 56 9819 1480 2346730
Acute kidney injury 174.30 33.39 138 9737 27984 2320226
Hypoglycaemia 172.18 33.39 88 9787 8319 2339891
Anosognosia 165.52 33.39 30 9845 47 2348163
Bipolar disorder 164.34 33.39 51 9824 1267 2346943
Paranoia 163.65 33.39 57 9818 2050 2346160
Hepatic steatosis 161.13 33.39 63 9812 3150 2345060
Cognitive disorder 160.80 33.39 73 9802 5308 2342902
Hepatocellular injury 160.27 33.39 67 9808 3988 2344222
Increased appetite 159.90 33.39 51 9824 1389 2346821
Death 158.67 33.39 214 9661 81254 2266956
Social avoidant behaviour 158.03 33.39 41 9834 518 2347692
Amenorrhoea 156.48 33.39 56 9819 2183 2346027
Dehydration 154.65 33.39 117 9758 22178 2326032
Disturbance in social behaviour 154.45 33.39 33 9842 163 2348047
Vomiting 151.58 33.39 196 9679 71406 2276804
Hyperthermia 150.76 33.39 49 9826 1419 2346791
Sinus tachycardia 148.62 33.39 60 9815 3265 2344945
Galactorrhoea 148.33 33.39 47 9828 1252 2346958
Pancreatitis 146.64 33.39 78 9797 8001 2340209
Altered state of consciousness 146.60 33.39 62 9813 3798 2344412
Dyslipidaemia 146.25 33.39 41 9834 706 2347504
Leukocytosis 144.39 33.39 60 9815 3516 2344694
Hypernatraemia 143.36 33.39 42 9833 852 2347358
Circulatory collapse 142.11 33.39 60 9815 3660 2344550
Product use in unapproved indication 140.74 33.39 85 9790 11115 2337095
Irritability 139.54 33.39 70 9805 6357 2341853
Thrombocytopenia 136.20 33.39 102 9773 19029 2329181
Disturbance in attention 135.55 33.39 66 9809 5619 2342591
Diabetic ketoacidosis 134.53 33.39 57 9818 3507 2344703
Pleurothotonus 133.73 33.39 31 9844 235 2347975
Poisoning 129.87 33.39 52 9823 2768 2345442
Deep vein thrombosis 129.51 33.39 85 9790 12847 2335363
Syncope 129.17 33.39 94 9781 16781 2331429
Urinary tract infection 128.37 33.39 119 9756 29823 2318387
Psychiatric decompensation 127.50 33.39 29 9846 200 2348010
Urinary retention 126.40 33.39 55 9820 3612 2344598
Platelet count decreased 125.40 33.39 90 9785 15723 2332487
Hyperhidrosis 125.11 33.39 89 9786 15333 2332877
Oculogyric crisis 124.58 33.39 31 9844 327 2347883
Personality change 124.02 33.39 38 9837 903 2347307
Unresponsive to stimuli 123.48 33.39 59 9816 4817 2343393
Hypokalaemia 121.46 33.39 76 9799 10578 2337632
Orthostatic hypotension 118.57 33.39 49 9826 2830 2345380
Bradycardia 118.34 33.39 73 9802 9908 2338302
Refusal of treatment by patient 117.06 33.39 39 9836 1222 2346988
Sudden death 116.83 33.39 43 9832 1817 2346393
Drug level increased 116.70 33.39 48 9827 2739 2345471
Torsade de pointes 116.00 33.39 45 9830 2201 2346009
Arrhythmia 114.47 33.39 60 9815 5968 2342242
Weight decreased 114.39 33.39 109 9766 28262 2319948
Obsessive-compulsive disorder 114.26 33.39 33 9842 635 2347575
Lethargy 111.57 33.39 67 9808 8663 2339547
Asthenia 111.11 33.39 136 9739 46790 2301420
Foetal exposure during pregnancy 110.47 33.39 56 9819 5196 2343014
Antipsychotic drug level increased 110.34 33.39 31 9844 538 2347672
Anaemia 109.72 33.39 117 9758 34675 2313535
Hepatic function abnormal 108.22 33.39 58 9817 6034 2342176
Polyuria 107.50 33.39 36 9839 1146 2347064
Decreased appetite 105.24 33.39 105 9770 28786 2319424
Epilepsy 105.03 33.39 52 9823 4587 2343623
Hyperlipidaemia 105.03 33.39 44 9831 2630 2345580
Sleep disorder 104.79 33.39 58 9817 6431 2341779
Menstruation irregular 103.52 33.39 38 9837 1593 2346617
Agranulocytosis 103.25 33.39 47 9828 3435 2344775
Polydipsia 102.50 33.39 30 9845 606 2347604
Psychomotor retardation 100.60 33.39 29 9846 554 2347656
Eosinophilia 100.58 33.39 44 9831 2926 2345284
Sepsis 100.23 33.39 84 9791 18404 2329806
General physical health deterioration 99.72 33.39 75 9800 14064 2334146
Posture abnormal 99.52 33.39 27 9848 409 2347801
Vision blurred 99.47 33.39 76 9799 14592 2333618
Speech disorder 96.83 33.39 55 9820 6409 2341801
Caesarean section 96.13 33.39 47 9828 4034 2344176
Mental impairment 95.33 33.39 40 9835 2400 2345810
Apathy 95.28 33.39 34 9841 1313 2346897
Maternal exposure during pregnancy 94.22 33.39 74 9801 14789 2333421
Fatigue 93.73 33.39 172 9703 84701 2263509
Thinking abnormal 93.55 33.39 37 9838 1905 2346305
Hepatic enzyme increased 92.23 33.39 62 9813 9740 2338470
Respiratory failure 91.51 33.39 70 9805 13458 2334752
Hypophagia 91.03 33.39 45 9830 3955 2344255
Inappropriate antidiuretic hormone secretion 90.70 33.39 38 9837 2271 2345939
Mutism 90.10 33.39 23 9852 271 2347939
Hypercholesterolaemia 89.20 33.39 34 9841 1584 2346626
Blood alkaline phosphatase increased 88.23 33.39 52 9823 6493 2341717
Neutrophil count decreased 88.07 33.39 52 9823 6515 2341695
Poisoning deliberate 87.79 33.39 31 9844 1160 2347050
Hypomania 87.19 33.39 28 9847 779 2347431
Psychiatric symptom 84.62 33.39 28 9847 858 2347352
Nausea 84.43 33.39 194 9681 111995 2236215
Renal failure 84.21 33.39 74 9801 17275 2330935
Coma scale abnormal 82.75 33.39 27 9848 791 2347419
Diabetic coma 81.97 33.39 20 9855 193 2348017
Homicide 81.72 33.39 18 9857 105 2348105
Memory impairment 81.17 33.39 64 9811 12859 2335351
Therapy non-responder 80.44 33.39 53 9822 8051 2340159
Major depression 80.19 33.39 28 9847 1013 2347197
Mental status changes 79.60 33.39 46 9829 5536 2342674
Schizoaffective disorder 79.03 33.39 20 9855 227 2347983
Stupor 78.87 33.39 25 9850 666 2347544
Myocardial infarction 78.38 33.39 74 9801 18939 2329271
Accidental overdose 76.72 33.39 40 9835 3932 2344278
Head injury 76.13 33.39 40 9835 3994 2344216
Platelet count increased 75.28 33.39 33 9842 2204 2346006
Myoclonus 75.13 33.39 34 9841 2449 2345761
Pancytopenia 74.69 33.39 58 9817 11394 2336816
Negativism 74.39 33.39 17 9858 120 2348090
Liver function test abnormal 74.37 33.39 49 9826 7441 2340769
Feeling abnormal 73.73 33.39 79 9796 23502 2324708
Malaise 73.42 33.39 122 9753 55463 2292747
Acute psychosis 73.30 33.39 22 9853 486 2347724
Medication error 73.04 33.39 45 9830 6086 2342124
Hypokinesia 72.71 33.39 30 9845 1724 2346486
Neutrophil count increased 72.12 33.39 31 9844 1974 2346236
Self esteem decreased 71.45 33.39 17 9858 146 2348064
Ileus paralytic 71.42 33.39 24 9851 772 2347438
Cerebrovascular accident 70.94 33.39 72 9803 20114 2328096
Amnesia 70.92 33.39 47 9828 7206 2341004
Electroencephalogram abnormal 70.52 33.39 24 9851 803 2347407
Diet refusal 70.44 33.39 17 9858 156 2348054
Disease recurrence 70.24 33.39 36 9839 3415 2344795
Cholelithiasis 70.17 33.39 43 9832 5760 2342450
Logorrhoea 69.80 33.39 21 9854 468 2347742
Hypothyroidism 69.65 33.39 39 9836 4418 2343792
Tachypnoea 68.96 33.39 31 9844 2198 2346012
Urinary incontinence 68.78 33.39 38 9837 4195 2344015
Withdrawal syndrome 68.46 33.39 35 9840 3302 2344908
Brain oedema 67.90 33.39 31 9844 2279 2345931
Blood pressure increased 67.89 33.39 65 9810 16921 2331289
Cogwheel rigidity 64.57 33.39 17 9858 228 2347982
Somatic symptom disorder of pregnancy 64.33 33.39 12 9863 24 2348186
Fear 64.22 33.39 31 9844 2585 2345625
Akinesia 64.13 33.39 18 9857 311 2347899
Antipsychotic drug level above therapeutic 64.10 33.39 16 9859 171 2348039
Depressive symptom 63.48 33.39 20 9855 522 2347688
Encephalopathy 63.47 33.39 37 9838 4524 2343686
Acute respiratory distress syndrome 63.14 33.39 33 9842 3259 2344951
Drug use disorder 62.18 33.39 18 9857 349 2347861
Hepatitis 61.80 33.39 41 9834 6296 2341914
Body temperature increased 61.43 33.39 32 9843 3139 2345071
Myocarditis 61.36 33.39 24 9851 1199 2347011
Pulmonary oedema 60.83 33.39 43 9832 7320 2340890
Incontinence 60.71 33.39 25 9850 1429 2346781
Hallucination, visual 60.40 33.39 31 9844 2948 2345262
Insurance issue 59.79 33.39 18 9857 402 2347808
Hypotonia 59.77 33.39 26 9849 1704 2346506
Drug withdrawal syndrome 59.06 33.39 41 9834 6780 2341430
Embolism venous 59.00 33.39 17 9858 324 2347886
Liver disorder 58.95 33.39 40 9835 6374 2341836
Asphyxia 58.60 33.39 22 9853 982 2347228
Pregnancy 57.87 33.39 43 9832 7906 2340304
Diabetic neuropathy 57.87 33.39 18 9857 450 2347760
Bipolar I disorder 57.86 33.39 17 9858 348 2347862
Ventricular tachycardia 57.22 33.39 30 9845 2981 2345229
Hyperphagia 57.03 33.39 16 9859 276 2347934
Dyspnoea 56.71 33.39 134 9741 78599 2269611
Meige's syndrome 56.70 33.39 10 9865 12 2348198
Bradyphrenia 56.67 33.39 22 9853 1077 2347133
Mydriasis 56.61 33.39 27 9848 2192 2346018
Orthostatic hypertension 56.54 33.39 12 9863 57 2348153
Depressed mood 56.50 33.39 36 9839 5162 2343048
Dry mouth 56.43 33.39 43 9832 8210 2340000
Blood sodium decreased 56.40 33.39 30 9845 3070 2345140
Psychomotor skills impaired 55.43 33.39 17 9858 405 2347805
Hypocalcaemia 55.35 33.39 32 9843 3851 2344359
Haemoglobin decreased 55.29 33.39 60 9815 18091 2330119
C-reactive protein increased 55.10 33.39 38 9837 6217 2341993
Hypertriglyceridaemia 53.63 33.39 20 9855 876 2347334
Hepatic failure 53.53 33.39 36 9839 5653 2342557
Haemorrhage 53.36 33.39 47 9828 10992 2337218
Musculoskeletal stiffness 53.01 33.39 49 9826 12198 2336012
Restless legs syndrome 53.01 33.39 26 9849 2245 2345965
Eating disorder 52.90 33.39 26 9849 2255 2345955
Ketoacidosis 52.89 33.39 20 9855 911 2347299
Anal incontinence 52.77 33.39 24 9851 1748 2346462
Dysuria 52.28 33.39 31 9844 3910 2344300
Blood pressure decreased 52.16 33.39 43 9832 9193 2339017
Menorrhagia 52.16 33.39 30 9845 3576 2344634
Epistaxis 52.06 33.39 44 9831 9735 2338475
Glycosylated haemoglobin increased 51.98 33.39 24 9851 1810 2346400
Decubitus ulcer 51.96 33.39 22 9853 1349 2346861
Suicidal behaviour 51.90 33.39 17 9858 504 2347706
Type 1 diabetes mellitus 51.90 33.39 18 9857 638 2347572
Sinus bradycardia 51.71 33.39 25 9850 2091 2346119
Cerebral atrophy 51.62 33.39 19 9856 802 2347408
Autonomic nervous system imbalance 51.40 33.39 16 9859 401 2347809
Therapeutic product effect incomplete 51.23 33.39 45 9830 10486 2337724
Heart rate increased 51.13 33.39 46 9829 11059 2337151
Pulmonary congestion 50.40 33.39 24 9851 1941 2346269
Pancreatitis acute 50.31 33.39 30 9845 3823 2344387
Self-injurious ideation 50.28 33.39 17 9858 557 2347653
Low density lipoprotein increased 50.27 33.39 21 9854 1245 2346965
Drooling 49.99 33.39 18 9857 713 2347497
Parkinson's disease 49.33 33.39 21 9854 1305 2346905
Electrocardiogram abnormal 49.00 33.39 21 9854 1327 2346883
Drug-induced liver injury 48.82 33.39 29 9846 3670 2344540
Acidosis 48.56 33.39 22 9853 1588 2346622
Oxygen saturation decreased 48.54 33.39 38 9837 7548 2340662
Analgesic drug level increased 48.05 33.39 14 9861 278 2347932
Ventricular fibrillation 47.82 33.39 24 9851 2177 2346033
Cardiac disorder 47.46 33.39 38 9837 7795 2340415
Coordination abnormal 47.12 33.39 23 9852 1965 2346245
Hunger 46.72 33.39 17 9858 694 2347516
Septic shock 46.57 33.39 36 9839 7018 2341192
Communication disorder 46.54 33.39 15 9860 422 2347788
Cerebral infarction 46.41 33.39 30 9845 4407 2343803
Blood cholesterol abnormal 46.40 33.39 14 9861 315 2347895
Wrong patient received product 46.13 33.39 13 9862 228 2347982
Brain injury 45.98 33.39 18 9857 901 2347309
Hallucinations, mixed 45.50 33.39 16 9859 591 2347619
Muscle twitching 45.40 33.39 25 9850 2740 2345470
Blood lactate dehydrogenase increased 45.16 33.39 27 9848 3457 2344753
Visual impairment 45.10 33.39 44 9831 11711 2336499
High density lipoprotein decreased 45.04 33.39 14 9861 349 2347861
Transient ischaemic attack 45.00 33.39 33 9842 5945 2342265
Atrial fibrillation 44.55 33.39 47 9828 13721 2334489
Electrocardiogram T wave inversion 44.45 33.39 16 9859 633 2347577
Shock 44.18 33.39 28 9847 3976 2344234
Lipase increased 44.17 33.39 20 9855 1442 2346768
Water intoxication 44.11 33.39 11 9864 117 2348093
Delusion of reference 43.66 33.39 9 9866 36 2348174
Hypoventilation 43.56 33.39 16 9859 671 2347539
Hypersomnia 43.33 33.39 23 9852 2343 2345867
Malnutrition 43.15 33.39 21 9854 1782 2346428
Abnormal clotting factor 43.08 33.39 9 9866 39 2348171
Granulocytopenia 42.98 33.39 19 9856 1294 2346916
Normochromic normocytic anaemia 42.58 33.39 16 9859 716 2347494
Balance disorder 42.18 33.39 39 9836 9708 2338502
Movement disorder 42.16 33.39 24 9851 2804 2345406
Maternal exposure during breast feeding 41.98 33.39 15 9860 581 2347629
Hypoxic-ischaemic encephalopathy 41.75 33.39 16 9859 756 2347454
Drug abuser 41.75 33.39 17 9858 944 2347266
Arteriosclerosis coronary artery 41.73 33.39 18 9857 1155 2347055
Hypoxia 41.59 33.39 32 9843 6195 2342015
Adverse drug reaction 41.50 33.39 36 9839 8247 2339963
Myocardial ischaemia 41.46 33.39 22 9853 2240 2345970
Brain stem thrombosis 41.44 33.39 7 9868 5 2348205
Haematocrit increased 41.34 33.39 12 9863 235 2347975
Alcohol use 41.14 33.39 14 9861 468 2347742
Hepatitis C 41.04 33.39 19 9856 1442 2346768
Acute hepatic failure 40.95 33.39 23 9852 2619 2345591
Hyperglycaemic hyperosmolar nonketotic syndrome 40.93 33.39 10 9865 97 2348113
Hypertonia 40.91 33.39 18 9857 1212 2346998
Skin laceration 40.63 33.39 23 9852 2659 2345551
Hyperammonaemia 40.58 33.39 16 9859 816 2347394
Selective eating disorder 40.32 33.39 13 9862 366 2347844
Abortion spontaneous 40.16 33.39 44 9831 13401 2334809
Aspiration 40.15 33.39 19 9856 1515 2346695
Chest pain 40.11 33.39 64 9811 28073 2320137
Therapy partial responder 39.73 33.39 13 9862 384 2347826
Skin striae 39.58 33.39 11 9864 183 2348027
Premature baby 39.38 33.39 24 9851 3180 2345030
Reduced facial expression 39.30 33.39 11 9864 188 2348022
Eosinophil count increased 39.03 33.39 17 9858 1117 2347093
Psychotic symptom 38.97 33.39 11 9864 194 2348016
Obsessive thoughts 38.97 33.39 11 9864 194 2348016
Long QT syndrome 38.77 33.39 14 9861 559 2347651
Cholestasis 38.53 33.39 25 9850 3696 2344514
Pallor 38.40 33.39 25 9850 3717 2344493
Transaminases increased 38.37 33.39 27 9848 4560 2343650
Congestive cardiomyopathy 38.32 33.39 16 9859 947 2347263
Alcohol abuse 38.20 33.39 12 9863 310 2347900
Polycystic ovaries 38.01 33.39 11 9864 213 2347997
International normalised ratio abnormal 38.01 33.39 14 9861 592 2347618
Dementia 37.96 33.39 22 9853 2659 2345551
Drug withdrawal syndrome neonatal 37.94 33.39 13 9862 444 2347766
Respiratory distress 37.90 33.39 28 9847 5101 2343109
Renal impairment 37.27 33.39 37 9838 10055 2338155
Panic attack 37.13 33.39 25 9850 3931 2344279
Intestinal obstruction 37.07 33.39 26 9849 4367 2343843
Crying 37.06 33.39 26 9849 4370 2343840
Cyanosis 36.97 33.39 23 9852 3162 2345048
Oedema 36.93 33.39 37 9838 10166 2338044
Bundle branch block right 36.80 33.39 15 9860 835 2347375
Oromandibular dystonia 36.78 33.39 9 9866 88 2348122
Suspiciousness 36.78 33.39 9 9866 88 2348122
Ileus 36.66 33.39 20 9855 2152 2346058
Breast enlargement 36.47 33.39 12 9863 361 2347849
Drug level above therapeutic 36.27 33.39 13 9862 508 2347702
Lipids increased 36.14 33.39 11 9864 255 2347955
Somnambulism 36.13 33.39 15 9860 875 2347335
Screaming 36.04 33.39 14 9861 686 2347524
Blood chloride decreased 35.93 33.39 14 9861 692 2347518
Vertigo 35.76 33.39 35 9840 9349 2338861
Ventricular extrasystoles 35.69 33.39 19 9856 1947 2346263
Hypercapnia 35.54 33.39 13 9862 539 2347671
Cotard's syndrome 35.27 33.39 7 9868 22 2348188
Headache 35.26 33.39 114 9761 80065 2268145
Diplopia 35.19 33.39 23 9852 3442 2344768
Abnormal weight gain 35.02 33.39 11 9864 284 2347926
Extensor plantar response 34.99 33.39 11 9864 285 2347925
Anticholinergic syndrome 34.99 33.39 11 9864 285 2347925
Drug monitoring procedure incorrectly performed 34.82 33.39 8 9867 58 2348152
Palpitations 34.55 33.39 45 9830 16411 2331799
Bradykinesia 34.25 33.39 13 9862 598 2347612
Ataxia 34.09 33.39 20 9855 2472 2345738
Intestinal pseudo-obstruction 33.76 33.39 9 9866 127 2348083
Product substitution issue 33.74 33.39 26 9849 5043 2343167

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuroleptic malignant syndrome 2270.28 31.29 545 10010 2603 1733623
Weight increased 2188.62 31.29 696 9859 10661 1725565
Overdose 1966.95 31.29 707 9848 15994 1720232
Toxicity to various agents 1441.23 31.29 662 9893 28479 1707747
Sedation 1235.32 31.29 342 10213 3075 1733151
Completed suicide 1215.36 31.29 496 10059 15816 1720410
Diabetes mellitus 1104.79 31.29 369 10186 6539 1729687
Agitation 1032.48 31.29 396 10159 10630 1725596
Somnolence 959.58 31.29 423 10132 16316 1719910
Psychotic disorder 940.50 31.29 303 10252 4753 1731473
Blood creatine phosphokinase increased 802.86 31.29 311 10244 8545 1727681
Drug ineffective 775.39 31.29 584 9971 63217 1673009
Aggression 746.14 31.29 288 10267 7827 1728399
Intentional overdose 733.00 31.29 280 10275 7390 1728836
Suicide attempt 714.45 31.29 272 10283 7109 1729117
Schizophrenia 711.82 31.29 199 10356 1847 1734379
Tachycardia 686.63 31.29 308 10247 12320 1723906
Extrapyramidal disorder 669.05 31.29 196 10359 2181 1734045
Prescribed overdose 651.63 31.29 180 10375 1590 1734636
Blood triglycerides increased 608.76 31.29 186 10369 2414 1733812
Drug interaction 604.50 31.29 367 10188 27591 1708635
Coma 587.21 31.29 235 10320 7027 1729199
Type 2 diabetes mellitus 582.30 31.29 167 10388 1711 1734515
Confusional state 580.54 31.29 325 10230 20953 1715273
Rhabdomyolysis 575.54 31.29 262 10293 10828 1725398
Delirium 511.12 31.29 205 10350 6157 1730069
Catatonia 507.78 31.29 128 10427 757 1735469
Parkinsonism 502.72 31.29 139 10416 1230 1734996
Intentional self-injury 499.47 31.29 161 10394 2512 1733714
Neutropenia 495.20 31.29 278 10277 17982 1718244
Akathisia 493.01 31.29 136 10419 1192 1735034
Pulmonary embolism 487.16 31.29 246 10309 12813 1723413
Sopor 480.41 31.29 146 10409 1855 1734371
Diabetic ketoacidosis 474.78 31.29 163 10392 3120 1733106
Electrocardiogram QT prolonged 449.88 31.29 180 10375 5365 1730861
Tremor 439.50 31.29 230 10325 12901 1723325
Muscle rigidity 435.75 31.29 133 10422 1715 1734511
Dysarthria 434.55 31.29 173 10382 5086 1731140
Condition aggravated 434.15 31.29 269 10286 20881 1715345
Leukopenia 432.17 31.29 198 10357 8282 1727944
Anxiety 430.52 31.29 240 10315 15287 1720939
Restlessness 427.42 31.29 162 10393 4159 1732067
Blood glucose increased 425.88 31.29 210 10345 10374 1725852
Mania 425.23 31.29 135 10420 1998 1734228
Hyperglycaemia 416.64 31.29 167 10388 4998 1731228
Blood cholesterol increased 413.33 31.29 144 10411 2882 1733344
Post-injection delirium sedation syndrome 412.29 31.29 74 10481 28 1736198
Drug abuse 410.84 31.29 223 10332 13466 1722760
Delusion 402.94 31.29 131 10424 2100 1734126
Pneumonia aspiration 399.75 31.29 163 10392 5103 1731123
Alanine aminotransferase increased 390.73 31.29 208 10347 12070 1724156
Hypertension 382.92 31.29 241 10314 19207 1717019
Depressed level of consciousness 377.34 31.29 167 10388 6425 1729801
Treatment noncompliance 374.40 31.29 155 10400 5046 1731180
Abnormal behaviour 370.53 31.29 163 10392 6179 1730047
Hypotension 356.14 31.29 271 10284 29383 1706843
Hepatic steatosis 352.97 31.29 123 10432 2461 1733765
Hyponatraemia 351.28 31.29 175 10380 8825 1727401
Disorientation 346.97 31.29 149 10406 5320 1730906
Hallucination, auditory 336.90 31.29 113 10442 2004 1734222
Loss of consciousness 332.49 31.29 200 10355 14675 1721551
Hypothermia 329.28 31.29 106 10449 1642 1734584
Suicidal ideation 327.58 31.29 164 10391 8354 1727872
Off label use 327.51 31.29 288 10267 38283 1697943
Aspartate aminotransferase increased 321.85 31.29 175 10380 10581 1725645
Tardive dyskinesia 319.45 31.29 94 10461 1058 1735168
Serotonin syndrome 317.59 31.29 116 10439 2672 1733554
Dystonia 314.54 31.29 106 10449 1908 1734318
Insomnia 308.40 31.29 197 10358 16079 1720147
Cardio-respiratory arrest 305.51 31.29 161 10394 9132 1727094
Fall 303.18 31.29 238 10317 26976 1709250
White blood cell count decreased 296.88 31.29 178 10377 12971 1723255
Cardiac arrest 294.83 31.29 190 10365 15740 1720486
Pyrexia 293.12 31.29 294 10261 46106 1690120
Priapism 284.83 31.29 91 10464 1373 1734853
Hyperhidrosis 273.98 31.29 166 10389 12322 1723904
Gait disturbance 269.20 31.29 165 10390 12505 1723721
Obesity 264.26 31.29 80 10475 999 1735227
Cardiometabolic syndrome 261.65 31.29 61 10494 243 1735983
White blood cell count increased 261.23 31.29 134 10421 7178 1729048
Increased appetite 259.45 31.29 77 10478 894 1735332
Seizure 258.68 31.29 193 10362 20248 1715978
Depression 258.19 31.29 178 10377 16491 1719735
Polydipsia 252.96 31.29 71 10484 665 1735561
Dyskinesia 248.53 31.29 106 10449 3713 1732513
Mental impairment 246.79 31.29 88 10467 1885 1734341
Respiratory arrest 240.89 31.29 118 10437 5721 1730505
Psychotic symptom 225.37 31.29 51 10504 172 1736054
Dysphagia 214.80 31.29 132 10423 10036 1726190
Vomiting 213.05 31.29 227 10328 38088 1698138
Miosis 208.08 31.29 72 10483 1406 1734820
Dyslipidaemia 205.57 31.29 62 10493 763 1735463
Thrombocytopenia 200.74 31.29 169 10386 21080 1715146
Oculogyric crisis 200.39 31.29 51 10504 314 1735912
Respiratory depression 196.13 31.29 77 10478 2170 1734056
Speech disorder 193.81 31.29 94 10461 4454 1731772
Hyperlipidaemia 193.21 31.29 76 10479 2153 1734073
Type 1 diabetes mellitus 192.24 31.29 59 10496 773 1735453
Deep vein thrombosis 189.91 31.29 121 10434 9799 1726427
Unresponsive to stimuli 186.25 31.29 92 10463 4537 1731689
Cognitive disorder 186.03 31.29 90 10465 4240 1731986
Mental disorder 185.22 31.29 79 10476 2764 1733462
Hospitalisation 183.35 31.29 130 10425 12570 1723656
Paranoia 180.78 31.29 72 10483 2109 1734117
Hallucination 177.44 31.29 108 10447 8062 1728164
Myocarditis 175.95 31.29 68 10487 1835 1734391
Dizziness 175.87 31.29 195 10360 34166 1702060
Salivary hypersecretion 174.36 31.29 63 10492 1402 1734824
Diabetic coma 172.62 31.29 41 10514 180 1736046
Gamma-glutamyltransferase increased 172.11 31.29 90 10465 5008 1731218
C-reactive protein increased 168.18 31.29 93 10462 5792 1730434
Disturbance in attention 166.92 31.29 83 10472 4151 1732075
Mental status changes 162.71 31.29 92 10463 5983 1730243
Thinking abnormal 162.07 31.29 58 10497 1254 1734972
Pneumonia 159.80 31.29 215 10340 45967 1690259
Pancreatitis 153.46 31.29 94 10461 7093 1729133
Hypercholesterolaemia 151.30 31.29 54 10501 1158 1735068
Urinary retention 150.71 31.29 84 10471 5311 1730915
Erectile dysfunction 150.67 31.29 79 10476 4418 1731808
Leukocytosis 150.42 31.29 73 10482 3460 1732766
Metabolic disorder 150.02 31.29 44 10511 488 1735738
Agranulocytosis 149.58 31.29 73 10482 3503 1732723
Intentional product misuse 148.90 31.29 93 10462 7265 1728961
Death 147.80 31.29 294 10261 87149 1649077
Neutrophil count decreased 146.60 31.29 86 10469 5995 1730231
Psychomotor hyperactivity 144.82 31.29 59 10496 1834 1734392
Asthenia 144.31 31.29 177 10378 34493 1701733
Sinus tachycardia 144.18 31.29 64 10491 2468 1733758
Hypertriglyceridaemia 140.16 31.29 51 10504 1158 1735068
Hypoglycaemia 139.65 31.29 94 10461 8344 1727882
Eosinophilia 138.59 31.29 69 10486 3458 1732768
Bipolar disorder 138.49 31.29 45 10510 717 1735509
Generalised tonic-clonic seizure 138.17 31.29 72 10483 3974 1732252
Hyperprolactinaemia 138.12 31.29 35 10520 211 1736015
Sudden death 131.97 31.29 63 10492 2877 1733349
Malaise 131.24 31.29 156 10399 29409 1706817
Pulmonary oedema 130.12 31.29 82 10473 6504 1729722
Urinary incontinence 130.09 31.29 61 10494 2675 1733551
Constipation 128.66 31.29 113 10442 14887 1721339
Blood prolactin increased 128.38 31.29 38 10517 436 1735790
Poisoning 125.18 31.29 58 10497 2474 1733752
Irritability 124.88 31.29 75 10480 5457 1730769
Chest pain 124.76 31.29 126 10429 19788 1716438
Withdrawal syndrome 124.41 31.29 56 10499 2232 1733994
Alcohol abuse 123.89 31.29 39 10516 558 1735668
Platelet count decreased 123.11 31.29 115 10440 16408 1719818
Blood lactate dehydrogenase increased 121.50 31.29 64 10491 3611 1732615
Blood alkaline phosphatase increased 121.34 31.29 72 10483 5123 1731103
Liver function test abnormal 119.94 31.29 74 10481 5652 1730574
Altered state of consciousness 118.74 31.29 62 10493 3435 1732791
Poisoning deliberate 118.41 31.29 41 10514 801 1735425
Feeling abnormal 118.20 31.29 95 10460 11071 1725155
Acute kidney injury 118.10 31.29 161 10394 34783 1701443
Hyperthermia 116.80 31.29 49 10506 1642 1734584
Obsessive-compulsive disorder 115.21 31.29 40 10515 788 1735438
Apathy 115.13 31.29 45 10510 1251 1734975
Cardiomyopathy 114.54 31.29 56 10499 2696 1733530
Psychiatric decompensation 114.29 31.29 31 10524 252 1735974
Transaminases increased 112.13 31.29 62 10493 3855 1732371
Bradycardia 110.17 31.29 89 10466 10445 1725781
Depressed mood 109.68 31.29 56 10499 2960 1733266
Persecutory delusion 109.16 31.29 33 10522 409 1735817
Ketoacidosis 109.05 31.29 38 10517 757 1735469
Hallucination, visual 108.64 31.29 53 10502 2539 1733687
Syncope 108.19 31.29 100 10455 14069 1722157
Polyuria 107.67 31.29 43 10512 1267 1734959
Sleep disorder 107.31 31.29 61 10494 4002 1732224
Myocardial infarction 106.95 31.29 135 10420 27039 1709187
Drug withdrawal syndrome neonatal 106.50 31.29 36 10519 652 1735574
Myoclonus 105.50 31.29 50 10505 2245 1733981
Refusal of treatment by patient 104.35 31.29 41 10514 1156 1735070
Arrhythmia 104.27 31.29 69 10486 5947 1730279
Foetal exposure during pregnancy 103.17 31.29 70 10485 6289 1729937
Aspiration 102.39 31.29 46 10509 1824 1734402
Body temperature increased 101.11 31.29 51 10504 2626 1733600
Sexual dysfunction 100.32 31.29 45 10510 1778 1734448
Bradyphrenia 99.86 31.29 34 10521 630 1735596
Disinhibition 99.40 31.29 29 10526 315 1735911
Sepsis 98.65 31.29 110 10445 19328 1716898
Hyperreflexia 98.12 31.29 33 10522 588 1735638
Bradykinesia 95.91 31.29 31 10524 485 1735741
Weight decreased 95.85 31.29 117 10438 22636 1713590
Glycosylated haemoglobin increased 95.60 31.29 44 10511 1847 1734379
Lethargy 95.47 31.29 70 10485 7114 1729112
Brain oedema 95.33 31.29 46 10509 2150 1734076
Renal failure 94.32 31.29 109 10446 19908 1716318
Sleep apnoea syndrome 93.14 31.29 45 10510 2109 1734117
Anticholinergic syndrome 92.37 31.29 24 10531 162 1736064
Blood prolactin abnormal 91.40 31.29 19 10536 37 1736189
Hepatic enzyme increased 91.35 31.29 66 10489 6555 1729671
Musculoskeletal stiffness 91.33 31.29 63 10492 5813 1730413
Social avoidant behaviour 89.41 31.29 31 10524 608 1735618
Visceral congestion 89.19 31.29 21 10534 88 1736138
Dyspnoea 88.67 31.29 176 10379 51883 1684343
Dehydration 88.00 31.29 99 10456 17559 1718667
Drug level increased 87.93 31.29 47 10508 2730 1733496
Epilepsy 87.58 31.29 53 10502 3906 1732320
Psychiatric symptom 86.03 31.29 32 10523 774 1735452
Red blood cell count decreased 85.83 31.29 51 10504 3635 1732591
Stupor 85.60 31.29 30 10525 608 1735618
Vision blurred 85.58 31.29 70 10485 8353 1727873
Euphoric mood 84.55 31.29 32 10523 813 1735413
Hyperphagia 84.23 31.29 24 10531 238 1735988
Drug-induced liver injury 83.86 31.29 48 10507 3189 1733037
Disturbance in social behaviour 83.73 31.29 23 10532 197 1736029
Ataxia 83.55 31.29 43 10512 2310 1733916
Schizoaffective disorder 83.52 31.29 23 10532 199 1736027
Emotional poverty 83.50 31.29 19 10536 66 1736160
Eosinophilic myocarditis 82.56 31.29 20 10535 97 1736129
Antipsychotic drug level below therapeutic 82.43 31.29 22 10533 167 1736059
Memory impairment 81.98 31.29 62 10493 6601 1729625
Hypomania 81.77 31.29 28 10527 528 1735698
Gynaecomastia 81.63 31.29 41 10514 2091 1734135
Orthostatic hypotension 81.26 31.29 48 10507 3383 1732843
Coma scale abnormal 79.73 31.29 28 10527 571 1735655
Dry mouth 77.95 31.29 49 10506 3864 1732362
Hypokalaemia 77.73 31.29 59 10496 6315 1729911
Mydriasis 77.07 31.29 34 10521 1290 1734936
Logorrhoea 77.06 31.29 26 10529 468 1735758
Pulmonary congestion 75.91 31.29 37 10518 1768 1734458
Hypertonia 75.79 31.29 34 10521 1343 1734883
Product substitution issue 75.29 31.29 45 10510 3241 1732985
Tension 74.44 31.29 23 10532 308 1735918
Posture abnormal 74.27 31.29 24 10531 375 1735851
Therapy non-responder 74.21 31.29 57 10498 6209 1730017
Therapeutic response decreased 73.98 31.29 54 10501 5446 1730780
Fatigue 73.91 31.29 161 10394 50620 1685606
High density lipoprotein decreased 73.45 31.29 27 10528 631 1735595
Hepatocellular injury 73.39 31.29 44 10511 3187 1733039
Motor dysfunction 73.15 31.29 31 10524 1065 1735161
Diabetic hyperosmolar coma 73.04 31.29 18 10537 95 1736131
Hypernatraemia 72.66 31.29 30 10525 964 1735262
Colitis ischaemic 72.45 31.29 29 10526 859 1735367
Eosinophil count increased 72.07 31.29 33 10522 1368 1734858
Depressive symptom 71.86 31.29 23 10532 348 1735878
Mutism 71.43 31.29 20 10535 185 1736041
Neutrophil count increased 71.35 31.29 40 10515 2553 1733673
Derealisation 70.98 31.29 19 10536 146 1736080
Heart rate increased 70.14 31.29 56 10499 6454 1729772
Respiratory failure 69.99 31.29 80 10475 14425 1721801
Hepatitis 69.72 31.29 50 10505 4905 1731321
Electroencephalogram abnormal 69.69 31.29 26 10529 634 1735592
Suspiciousness 69.10 31.29 17 10538 89 1736137
Drug level above therapeutic 68.49 31.29 24 10531 486 1735740
Water intoxication 67.98 31.29 18 10537 132 1736094
Therapeutic product effect incomplete 67.69 31.29 51 10504 5397 1730829
Torsade de pointes 67.52 31.29 31 10524 1293 1734933
General physical health deterioration 66.09 31.29 74 10481 13044 1723182
Blepharospasm 65.99 31.29 20 10535 250 1735976
Pancytopenia 65.84 31.29 69 10486 11288 1724938
Accidental overdose 65.53 31.29 45 10510 4119 1732107
Eye movement disorder 65.18 31.29 27 10528 875 1735351
Antipsychotic drug level increased 64.73 31.29 25 10530 672 1735554
Headache 64.25 31.29 121 10434 34255 1701971
Pancreatitis acute 63.92 31.29 44 10511 4043 1732183
Hyperammonaemia 63.77 31.29 28 10527 1050 1735176
Psychomotor retardation 63.56 31.29 22 10533 429 1735797
Amnesia 63.47 31.29 47 10508 4844 1731382
Exposure during pregnancy 63.04 31.29 38 10517 2779 1733447
Acute psychosis 62.72 31.29 22 10533 447 1735779
Medication error 62.50 31.29 46 10509 4697 1731529
Obsessive thoughts 62.41 31.29 18 10537 187 1736039
Blood sodium decreased 61.92 31.29 35 10520 2269 1733957
Drooling 61.79 31.29 25 10530 762 1735464
Selective eating disorder 61.13 31.29 21 10534 400 1735826
Disease recurrence 60.82 31.29 36 10519 2546 1733680
Movement disorder 60.67 31.29 31 10524 1639 1734587
Anosognosia 60.38 31.29 14 10541 54 1736172
Hepatic fibrosis 60.09 31.29 23 10532 603 1735623
Alcohol use 59.90 31.29 25 10530 826 1735400
Liver disorder 59.68 31.29 48 10507 5588 1730638
Hypersomnia 59.42 31.29 31 10524 1712 1734514
Xanthoma 59.08 31.29 13 10542 37 1736189
Respiratory distress 59.07 31.29 46 10509 5111 1731115
Hyperglycaemic hyperosmolar nonketotic syndrome 59.00 31.29 17 10538 176 1736050
Pallor 58.78 31.29 39 10516 3372 1732854
Tachypnoea 58.50 31.29 34 10521 2324 1733902
Balance disorder 58.38 31.29 48 10507 5764 1730462
Hypotonia neonatal 57.99 31.29 18 10537 245 1735981
Snoring 57.89 31.29 21 10534 472 1735754
Product use in unapproved indication 57.77 31.29 59 10496 9363 1726863
Feeling guilty 57.77 31.29 14 10541 68 1736158
Asphyxia 57.25 31.29 26 10529 1057 1735169
Cogwheel rigidity 57.18 31.29 17 10538 198 1736028
Pancreatitis necrotising 56.76 31.29 20 10535 412 1735814
Torticollis 55.48 31.29 18 10537 285 1735941
Hypoglycaemia neonatal 54.85 31.29 18 10537 296 1735930
Ejection fraction decreased 54.71 31.29 32 10523 2213 1734013
Drug screen positive 54.69 31.29 25 10530 1032 1735194
Illness anxiety disorder 54.58 31.29 12 10543 34 1736192
Somnambulism 53.72 31.29 22 10533 692 1735534
Palpitations 53.71 31.29 49 10506 6765 1729461
Ileus paralytic 53.60 31.29 24 10531 943 1735283
Aphasia 53.50 31.29 37 10518 3424 1732802
Gastrointestinal sounds abnormal 53.40 31.29 19 10536 403 1735823
Blood cholesterol abnormal 53.31 31.29 16 10539 193 1736033
Drug withdrawal syndrome 53.21 31.29 41 10514 4484 1731742
Haematocrit decreased 53.07 31.29 40 10515 4233 1731993
Restless legs syndrome 52.45 31.29 24 10531 993 1735233
Liver injury 51.68 31.29 29 10526 1853 1734373
Hypoxia 51.20 31.29 45 10510 5918 1730308
Cardiomegaly 50.97 31.29 31 10524 2303 1733923
Inappropriate antidiuretic hormone secretion 50.91 31.29 28 10527 1720 1734506
Metabolic acidosis 50.91 31.29 43 10512 5359 1730867
Blood chloride decreased 50.85 31.29 20 10535 565 1735661
Negativism 50.85 31.29 14 10541 121 1736105
Lymphocyte count increased 50.67 31.29 19 10536 470 1735756
Low density lipoprotein increased 50.39 31.29 23 10532 946 1735280
Faecaloma 50.36 31.29 21 10534 692 1735534
Muscle twitching 50.12 31.29 28 10527 1774 1734452
Drug dependence 50.10 31.29 35 10520 3292 1732934
Hunger 49.37 31.29 17 10538 326 1735900
Hepatosplenomegaly 49.20 31.29 20 10535 617 1735609
Glucose tolerance impaired 48.94 31.29 18 10537 421 1735805
Blood creatine phosphokinase MB increased 48.32 31.29 18 10537 437 1735789
Hepatitis C 48.25 31.29 32 10523 2764 1733462
Thirst 48.15 31.29 24 10531 1203 1735023
Blood pressure increased 47.99 31.29 57 10498 10696 1725530
Pleurothotonus 47.74 31.29 14 10541 155 1736071
Delusion of replacement 47.28 31.29 10 10545 22 1736204
Drug reaction with eosinophilia and systemic symptoms 47.04 31.29 40 10515 5030 1731196
Respiratory rate increased 46.95 31.29 24 10531 1270 1734956
Nausea 46.70 31.29 136 10419 51060 1685166
Therapeutic product effect variable 46.55 31.29 13 10542 119 1736107
Substance abuse 46.54 31.29 22 10533 981 1735245
Maternal drugs affecting foetus 46.24 31.29 23 10532 1148 1735078
Oral discharge 46.11 31.29 10 10545 26 1736200
Spasmodic dysphonia 46.11 31.29 10 10545 26 1736200
Cerebral atrophy 46.07 31.29 20 10535 729 1735497
Incontinence 46.06 31.29 22 10533 1004 1735222
Cerebellar syndrome 45.68 31.29 18 10537 511 1735715
Grandiosity 45.68 31.29 12 10543 85 1736141
Alcoholism 45.55 31.29 18 10537 515 1735711
Acute pulmonary oedema 45.40 31.29 23 10532 1194 1735032
Supraventricular extrasystoles 45.37 31.29 19 10536 633 1735593
Wrong patient received product 45.20 31.29 14 10541 189 1736037
Blood creatinine increased 45.07 31.29 63 10492 13883 1722343
Drug intolerance 44.69 31.29 42 10513 6020 1730206
Cholelithiasis 44.66 31.29 32 10523 3133 1733093
Panic attack 44.08 31.29 26 10529 1826 1734400
Hypophagia 44.01 31.29 33 10522 3464 1732762
Incoherent 44.01 31.29 20 10535 814 1735412
Sluggishness 43.96 31.29 19 10536 685 1735541
Dementia 43.63 31.29 27 10528 2069 1734157
Judgement impaired 43.45 31.29 13 10542 155 1736071
Depersonalisation/derealisation disorder 43.15 31.29 13 10542 159 1736067
Mitral valve incompetence 42.94 31.29 26 10529 1916 1734310
Blood chloride increased 42.84 31.29 15 10540 303 1735923
Loss of personal independence in daily activities 42.71 31.29 28 10527 2371 1733855
Meige's syndrome 42.64 31.29 8 10547 6 1736220
Hypotonia 42.59 31.29 24 10531 1546 1734680
Abdominal distension 42.52 31.29 42 10513 6402 1729824
Fear 42.42 31.29 23 10532 1373 1734853
Urinary tract infection 42.33 31.29 52 10503 10101 1726125
Delusional disorder, persecutory type 42.24 31.29 11 10544 75 1736151
Impaired self-care 42.21 31.29 13 10542 172 1736054
Autonomic nervous system imbalance 42.10 31.29 16 10539 411 1735815
Circulatory collapse 42.05 31.29 32 10523 3435 1732791
Respiration abnormal 41.56 31.29 16 10539 426 1735800
Red blood cell count increased 41.43 31.29 14 10541 253 1735973
Hyperosmolar state 41.26 31.29 11 10544 83 1736143
Haemoglobin decreased 40.67 31.29 67 10488 17047 1719179
Gastritis 40.54 31.29 30 10525 3087 1733139
Ventricular hypokinesia 40.40 31.29 18 10537 699 1735527
Epistaxis 40.35 31.29 46 10509 8260 1727966
Pericarditis 40.34 31.29 23 10532 1515 1734711
Perseveration 40.31 31.29 9 10546 28 1736198
Hepatitis viral 40.27 31.29 12 10543 141 1736085
Self-injurious ideation 40.23 31.29 15 10540 365 1735861
Somatic symptom disorder 40.19 31.29 12 10543 142 1736084
Anger 40.03 31.29 28 10527 2638 1733588
Hypokinesia 39.81 31.29 21 10534 1186 1735040
Hyperpyrexia 39.67 31.29 17 10538 600 1735626
Cardiac failure 39.34 31.29 56 10499 12546 1723680
Heat stroke 39.21 31.29 13 10542 221 1736005
Communication disorder 39.01 31.29 15 10540 398 1735828
Embolism venous 38.94 31.29 13 10542 226 1736000
Eating disorder 38.93 31.29 21 10534 1241 1734985
Agitated depression 38.75 31.29 9 10546 35 1736191
Bipolar I disorder 38.62 31.29 13 10542 232 1735994
Decreased activity 37.96 31.29 17 10538 668 1735558
Anal incontinence 37.64 31.29 20 10535 1146 1735080
Blood cholesterol decreased 37.53 31.29 13 10542 254 1735972
Blood urea increased 37.36 31.29 34 10521 4677 1731549
General physical condition abnormal 37.33 31.29 17 10538 695 1735531
Poor quality sleep 37.26 31.29 20 10535 1170 1735056
Suicidal behaviour 36.93 31.29 14 10541 357 1735869
Cellulitis 36.93 31.29 39 10516 6429 1729797
Staring 36.75 31.29 14 10541 362 1735864
Blunted affect 36.67 31.29 10 10545 83 1736143
Rectal haemorrhage 36.33 31.29 36 10519 5506 1730720
Cerebrovascular stenosis 36.30 31.29 8 10547 23 1736203
Atrioventricular block first degree 35.82 31.29 18 10537 918 1735308
Blood disorder 35.79 31.29 16 10539 626 1735600
Anaemia 35.67 31.29 87 10468 29370 1706856
Abdominal pain 35.65 31.29 72 10483 21418 1714808
Coordination abnormal 35.58 31.29 21 10534 1476 1734750
Food craving 35.57 31.29 10 10545 94 1736132
Fear of disease 35.44 31.29 7 10548 9 1736217
Extrasystoles 35.42 31.29 17 10538 784 1735442
Enuresis 35.41 31.29 14 10541 401 1735825
Megacolon 35.39 31.29 13 10542 303 1735923
Ventricular tachycardia 35.30 31.29 30 10525 3768 1732458
Diabetes insipidus 35.18 31.29 14 10541 408 1735818
Homicide 34.76 31.29 13 10542 319 1735907
Oedema peripheral 34.44 31.29 59 10496 15491 1720735
Lymphopenia 34.43 31.29 23 10532 2010 1734216
Symptom masked 33.87 31.29 9 10546 67 1736159
Slow response to stimuli 33.74 31.29 11 10544 177 1736049
Drug abuser 33.49 31.29 20 10535 1437 1734789
Sinus bradycardia 33.05 31.29 22 10533 1911 1734315
Foetal alcohol syndrome 32.91 31.29 7 10548 16 1736210
Impaired work ability 32.88 31.29 18 10537 1095 1735131
Lymphocyte count decreased 32.80 31.29 23 10532 2175 1734051
Disorganised speech 32.66 31.29 9 10546 78 1736148
Diabetic neuropathy 32.44 31.29 14 10541 503 1735723
Pharyngitis 32.36 31.29 18 10537 1130 1735096
Breast engorgement 32.27 31.29 6 10549 4 1736222
Rebound psychosis 31.79 31.29 7 10548 20 1736206
Blood bicarbonate decreased 31.68 31.29 13 10542 411 1735815
Blood pressure decreased 31.61 31.29 39 10516 7607 1728619
Ewing's sarcoma 31.59 31.29 8 10547 48 1736178
Treatment failure 31.50 31.29 30 10525 4371 1731855
Psychotic behaviour 31.38 31.29 10 10545 149 1736077

Pharmacologic Action:

SourceCodeDescription
ATC N05AH03 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Diazepines, oxazepines, thiazepines and oxepines
FDA EPC N0000175430 Atypical Antipsychotic
CHEBI has role CHEBI:37956 histamine antagonist
CHEBI has role CHEBI:48876 muscarinic antagonist
CHEBI has role CHEBI:48279 serotonergic antagonist
CHEBI has role CHEBI:48561 dopaminergic antagonist
CHEBI has role CHEBI:50919 antiemetic
CHEBI has role CHEBI:50949 serotonin uptake inhibitor
CHEBI has role CHEBI:65191 second generation antipsychotic
MeSH PA D000932 Antiemetics
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D018490 Serotonin Agents
MeSH PA D017367 Serotonin Uptake Inhibitors
MeSH PA D014149 Tranquilizing Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Mixed bipolar I disorder indication 16506000 DOID:3312
Schizophrenia indication 58214004 DOID:5419
Bipolar disorder in remission indication 85248005
Bipolar affective disorder, current episode manic indication 191618007
Bipolar affective disorder, current episode depression indication 191627008 DOID:3312
Major depressive disorder indication 370143000
Agitation associated with Bipolar Mania indication
Agitation associated with Schizophrenia indication
Depression Treatment Adjunct indication
Chemotherapy-induced nausea and vomiting off-label use 236084000
Delirium contraindication 2776000
Suicidal thoughts contraindication 6471006
Weight gain finding contraindication 8943002
Sinus tachycardia contraindication 11092001
Hypercholesterolemia contraindication 13644009
Bipolar disorder contraindication 13746004 DOID:3312
Neuroleptic malignant syndrome contraindication 15244003 DOID:14464
Senile dementia contraindication 15662003
Agranulocytosis contraindication 17182001 DOID:12987
Lowered convulsive threshold contraindication 19260006
Cirrhosis of liver contraindication 19943007 DOID:5082
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Dehydration contraindication 34095006
Upper gastrointestinal hemorrhage contraindication 37372002
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Bradycardia contraindication 48867003
Syndrome of inappropriate vasopressin secretion contraindication 55004003 DOID:3401
Paralytic ileus contraindication 55525008 DOID:8442
Hyperlipidemia contraindication 55822004 DOID:1168
Anorexia nervosa contraindication 56882008 DOID:8689
Abnormal sexual function contraindication 56925008
Hepatic failure contraindication 59927004
Cerebrovascular disease contraindication 62914000 DOID:6713
Blood coagulation disorder contraindication 64779008 DOID:1247
Sedation contraindication 72641008
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperglycemia contraindication 80394007 DOID:4195
Heart failure contraindication 84114007 DOID:6000
Epilepsy contraindication 84757009 DOID:1826
Leukopenia contraindication 84828003 DOID:615
Hyponatremia contraindication 89627008
Tardive dyskinesia contraindication 102449007
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Cerebrovascular accident contraindication 230690007
Mania contraindication 231494001
Hypomania contraindication 231496004
Disease of liver contraindication 235856003 DOID:409
Metabolic syndrome X contraindication 237602007 DOID:14221
Hyperprolactinemia contraindication 237662005 DOID:12700
Transient ischemic attack contraindication 266257000 DOID:224
Esophageal dysmotility contraindication 266434009 DOID:9192
Benign prostatic hyperplasia contraindication 266569009
Hypertriglyceridemia contraindication 302870006
Neutropenic disorder contraindication 303011007 DOID:1227
Serotonin syndrome contraindication 371089000
Coma contraindication 371632003
At risk for aspiration contraindication 371736008
Angle-closure glaucoma contraindication 392291006 DOID:13550
Myocardial ischemia contraindication 414795007 DOID:3393
Obesity contraindication 414916001 DOID:9970
Carcinoma of female breast contraindication 447782002
Smokes tobacco daily contraindication 449868002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.59 Basic
pKa2 5.72 Basic
pKa3 0.66 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 8.32 WOMBAT-PK CHEMBL
D(2) dopamine receptor GPCR ANTAGONIST Ki 8.52 WOMBAT-PK CHEMBL
D(4) dopamine receptor GPCR ANTAGONIST Ki 8.80 WOMBAT-PK
5-hydroxytryptamine receptor 1E GPCR AGONIST Ki 5.70 IUPHAR
Sodium-dependent serotonin transporter Transporter Ki 6.26 DRUG MATRIX
Alpha-1D adrenergic receptor GPCR Ki 7.59 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR Kd 5.90 CHEMBL
D(3) dopamine receptor GPCR ANTAGONIST Ki 8.10 WOMBAT-PK
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST Ki 7.96 WOMBAT-PK
5-hydroxytryptamine receptor 1F GPCR Ki 6.51 WOMBAT-PK
Alpha-1B adrenergic receptor GPCR Ki 6.58 WOMBAT-PK
5-hydroxytryptamine receptor 3A Ion channel Ki 6.69 WOMBAT-PK
Alpha-2C adrenergic receptor GPCR Ki 7.54 WOMBAT-PK
5-hydroxytryptamine receptor 1D GPCR Ki 6.12 WOMBAT-PK
5-hydroxytryptamine receptor 1B GPCR Ki 6.23 WOMBAT-PK
Aldehyde oxidase Enzyme IC50 5.22 WOMBAT-PK
Muscarinic acetylcholine receptor M5 GPCR Ki 8.05 WOMBAT-PK
Muscarinic acetylcholine receptor M4 GPCR Ki 7.68 WOMBAT-PK
Muscarinic acetylcholine receptor M3 GPCR Ki 7.14 WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR Ki 7.10 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR Ki 7.51 WOMBAT-PK
Histamine H2 receptor GPCR Ki 7.36 WOMBAT-PK
Histamine H1 receptor GPCR Ki 8.15 WOMBAT-PK
D(1B) dopamine receptor GPCR Ki 7.05 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 7.09 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR Ki 7.72 WOMBAT-PK
5-hydroxytryptamine receptor 7 GPCR Ki 6.98 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 8.10 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR Ki 7.92 WOMBAT-PK
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.74 WOMBAT-PK
Alpha-2A adrenergic receptor GPCR Ki 6.49 WOMBAT-PK
D(1A) dopamine receptor GPCR Ki 7.40 WOMBAT-PK
5-hydroxytryptamine receptor 5A GPCR Ki 5.92 PDSP
Beta-2 adrenergic receptor GPCR Ki 5.30 PDSP
Beta-1 adrenergic receptor GPCR Ki 5.30 PDSP
FAD-linked sulfhydryl oxidase ALR Enzyme AC50 6.43 CHEMBL
Arachidonate 15-lipoxygenase Enzyme IC50 5.56 DRUG MATRIX
Alpha-1B adrenergic receptor GPCR Ki 7.68 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR Ki 6.36 DRUG MATRIX
D(1A) dopamine receptor GPCR Ki 7.70 CHEMBL
Histamine H1 receptor GPCR Ki 9.52 CHEMBL
Transporter Transporter Ki 5.70 CHEMBL
Transporter Transporter Ki 6.02 CHEMBL
D(3) dopamine receptor GPCR Ki 7.41 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR Ki 7.92 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 5.54 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 7.66 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 6.21 CHEMBL
D(2) dopamine receptor GPCR Ki 7.90 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 8.40 CHEMBL
D(4) dopamine receptor GPCR Ki 7.30 CHEMBL
Histamine H1 receptor GPCR Ki 8.20 CHEMBL
5-hydroxytryptamine receptor 6 GPCR ANTAGONIST Ki 8.60 IUPHAR
Alpha-1A adrenergic receptor GPCR IC50 7.19 CHEMBL
5-hydroxytryptamine receptor 7 GPCR ANTAGONIST Ki 7 IUPHAR

External reference:

IDSource
D000077152 MESH_DESCRIPTOR_UI
4020996 VUID
N0000148465 NUI
C0171023 UMLSCUI
D00454 KEGG_DRUG
108441004 SNOMEDCT_US
4020996 VANDF
006204 NDDF
61381 RXNORM
d04050 MMSL
172501 MMSL
5198 MMSL
386849001 SNOMEDCT_US
CHEMBL715 ChEMBL_ID
DB00334 DRUGBANK_ID
N7U69T4SZR UNII
6956 INN_ID
CHEBI:7735 CHEBI
221373-18-8 SECONDARY_CAS_RN
135398745 PUBCHEM_CID
CHEMBL1201741 ChEMBL_ID
CHEMBL3989694 ChEMBL_ID
47 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3230 CAPSULE 3 mg ORAL NDA 20 sections
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3231 CAPSULE 6 mg ORAL NDA 20 sections
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3232 CAPSULE 12 mg ORAL NDA 20 sections
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3233 CAPSULE 6 mg ORAL NDA 20 sections
Symbyax HUMAN PRESCRIPTION DRUG LABEL 2 0002-3234 CAPSULE 12 mg ORAL NDA 20 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4112 TABLET 2.50 mg ORAL NDA 22 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4115 TABLET 5 mg ORAL NDA 22 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4116 TABLET 7.50 mg ORAL NDA 22 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4117 TABLET 10 mg ORAL NDA 22 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4415 TABLET 15 mg ORAL NDA 22 sections
Zyprexa HUMAN PRESCRIPTION DRUG LABEL 1 0002-4420 TABLET 20 mg ORAL NDA 22 sections
ZYPREXA HUMAN PRESCRIPTION DRUG LABEL 1 0002-4453 TABLET, ORALLY DISINTEGRATING 5 mg ORAL NDA 22 sections
ZYPREXA HUMAN PRESCRIPTION DRUG LABEL 1 0002-4454 TABLET, ORALLY DISINTEGRATING 10 mg ORAL NDA 22 sections
ZYPREXA HUMAN PRESCRIPTION DRUG LABEL 1 0002-4455 TABLET, ORALLY DISINTEGRATING 15 mg ORAL NDA 22 sections
ZYPREXA HUMAN PRESCRIPTION DRUG LABEL 1 0002-4456 TABLET, ORALLY DISINTEGRATING 20 mg ORAL NDA 22 sections
ZYPREXA HUMAN PRESCRIPTION DRUG LABEL 1 0002-7597 INJECTION, POWDER, FOR SOLUTION 10 mg INTRAMUSCULAR NDA 22 sections
ZYPREXA HUMAN PRESCRIPTION DRUG LABEL 1 0002-7635 KIT 210 mg INTRAMUSCULAR NDA 21 sections
ZYPREXA HUMAN PRESCRIPTION DRUG LABEL 1 0002-7636 KIT 300 mg INTRAMUSCULAR NDA 21 sections
ZYPREXA HUMAN PRESCRIPTION DRUG LABEL 1 0002-7637 KIT 405 mg INTRAMUSCULAR NDA 21 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5245 TABLET, ORALLY DISINTEGRATING 5 mg ORAL ANDA 20 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5246 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 20 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5247 TABLET, ORALLY DISINTEGRATING 15 mg ORAL ANDA 20 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0093-5248 TABLET, ORALLY DISINTEGRATING 20 mg ORAL ANDA 20 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5503 CAPSULE 3 mg ORAL ANDA 19 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5504 CAPSULE 6 mg ORAL ANDA 19 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5505 CAPSULE 6 mg ORAL ANDA 19 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5506 CAPSULE 12 mg ORAL ANDA 19 sections
Olanzapine and Fluoxetine HUMAN PRESCRIPTION DRUG LABEL 2 0093-5507 CAPSULE 12 mg ORAL ANDA 19 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-5510 TABLET, ORALLY DISINTEGRATING 5 mg ORAL ANDA 19 sections
Olanzapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-5511 TABLET, ORALLY DISINTEGRATING 10 mg ORAL ANDA 19 sections