amphotericin B 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, polyene derivatives 197 1397-89-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • amphotericin B
  • abelcet
  • abelecet
  • amphocin
  • amphozone
  • apothecon
  • fungilin
  • Amphotericin B liposome
Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.
  • Molecular weight: 924.09
  • Formula: C47H73NO17
  • CLOGP: -3.65
  • LIPINSKI: 3
  • HAC: 18
  • HDO: 12
  • TPSA: 319.61
  • ALOGS: -4.05
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
40 mg O
0.40 g O
0.20 g V
35 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.00 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 3.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 4.33 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 3 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.62 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.17 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.03 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 40 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 12, 1964 FDA APOTHECON

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Multiple organ dysfunction syndrome 491.59 17.96 275 20082 56477 63412188
Drug ineffective 262.38 17.96 828 19529 1043937 62424728
Mucormycosis 256.08 17.96 75 20282 2796 63465869
Septic shock 234.21 17.96 184 20173 66445 63402220
Aspergillus infection 214.34 17.96 85 20272 8008 63460657
Bronchopulmonary aspergillosis 202.17 17.96 83 20274 8552 63460113
Febrile neutropenia 167.55 17.96 198 20159 118251 63350414
Hypokalaemia 152.58 17.96 177 20180 103627 63365038
Fatigue 147.39 17.96 51 20306 887977 62580688
Toxic epidermal necrolysis 144.47 17.96 94 20263 25240 63443425
Sepsis 136.25 17.96 204 20153 152919 63315746
Drug resistance 133.00 17.96 86 20271 22847 63445818
Neutropenia 130.54 17.96 215 20142 174790 63293875
Immune reconstitution inflammatory syndrome 127.34 17.96 54 20303 6030 63462635
Respiratory failure 122.55 17.96 157 20200 101701 63366964
Pathogen resistance 121.46 17.96 53 20304 6345 63462320
Acute kidney injury 120.98 17.96 263 20094 263152 63205513
Pain 104.33 17.96 54 20303 740574 62728091
Fungaemia 103.19 17.96 36 20321 2367 63466298
Pneumonia fungal 102.94 17.96 45 20312 5410 63463255
Haemophagocytic lymphohistiocytosis 101.45 17.96 55 20302 10572 63458093
Graft versus host disease 99.80 17.96 47 20310 6716 63461949
Renal impairment 98.19 17.96 131 20226 88224 63380441
Systemic candida 96.21 17.96 37 20320 3208 63465457
Febrile bone marrow aplasia 90.27 17.96 45 20312 7280 63461385
Rash maculo-papular 88.78 17.96 77 20280 31819 63436846
Arthralgia 88.73 17.96 36 20321 569674 62898991
Candida sepsis 88.59 17.96 28 20329 1352 63467313
Joint swelling 88.24 17.96 4 20353 327662 63141003
Nephropathy toxic 84.80 17.96 47 20310 9432 63459233
Systemic mycosis 84.01 17.96 26 20331 1171 63467494
Pancytopenia 83.07 17.96 127 20230 96806 63371859
Thrombocytopenia 82.27 17.96 162 20195 150995 63317670
Pyrexia 79.97 17.96 330 20027 470148 62998517
Posterior reversible encephalopathy syndrome 78.96 17.96 56 20301 17289 63451376
Drug ineffective for unapproved indication 78.60 17.96 74 20283 33989 63434676
Cholestasis 77.79 17.96 69 20288 29365 63439300
Renal failure 75.08 17.96 135 20222 117517 63351148
Candida infection 74.01 17.96 66 20291 28285 63440380
Cytomegalovirus infection 73.81 17.96 58 20299 20894 63447771
Leukopenia 73.00 17.96 106 20251 77184 63391481
Headache 71.64 17.96 59 20298 633182 62835483
Product use in unapproved indication 71.16 17.96 169 20188 178911 63289754
Dizziness 70.48 17.96 25 20332 429900 63038765
Drug level below therapeutic 69.29 17.96 33 20324 4833 63463832
Fungal endocarditis 69.28 17.96 16 20341 227 63468438
Fungal infection 68.19 17.96 71 20286 36803 63431862
Mucosal inflammation 67.15 17.96 79 20278 46849 63421816
Off label use 65.61 17.96 404 19953 674058 62794607
Rheumatoid arthritis 65.48 17.96 4 20353 253815 63214850
Alopecia 63.80 17.96 15 20342 337521 63131144
Swelling 63.72 17.96 7 20350 275371 63193294
Fungal sepsis 62.22 17.96 21 20336 1249 63467416
Abdominal discomfort 61.16 17.96 14 20343 320871 63147794
Aplastic anaemia 58.22 17.96 37 20320 9532 63459133
Fall 57.49 17.96 27 20330 392307 63076358
Enterococcal infection 57.06 17.96 34 20323 7814 63460851
Cerebral aspergillosis 55.76 17.96 15 20342 407 63468258
Graft versus host disease in gastrointestinal tract 55.56 17.96 25 20332 3216 63465449
Hyperammonaemia 55.34 17.96 29 20328 5203 63463462
Drug intolerance 53.98 17.96 16 20341 308645 63160020
Nasopharyngitis 52.82 17.96 9 20348 254248 63214417
Hyperbilirubinaemia 52.58 17.96 37 20320 11277 63457388
Product dose omission issue 51.63 17.96 7 20350 234306 63234359
Shock 50.38 17.96 49 20308 23414 63445251
Therapeutic product effect decreased 49.95 17.96 3 20354 193184 63275481
Systemic inflammatory response syndrome 47.90 17.96 27 20330 5594 63463071
Scedosporium infection 47.10 17.96 14 20343 549 63468116
Drug level increased 46.07 17.96 46 20311 22690 63445975
Pseudomonas infection 46.01 17.96 34 20323 11179 63457486
Dermatitis exfoliative 45.92 17.96 26 20331 5433 63463232
Stenotrophomonas infection 45.79 17.96 19 20338 2008 63466657
Malaise 45.42 17.96 40 20317 415914 63052751
Fusarium infection 45.20 17.96 14 20343 632 63468033
Perinephric abscess 45.18 17.96 11 20346 198 63468467
Ureaplasma infection 45.09 17.96 14 20343 637 63468028
Geotrichum infection 44.99 17.96 13 20344 461 63468204
Histoplasmosis disseminated 44.59 17.96 17 20340 1439 63467226
Musculoskeletal stiffness 44.49 17.96 4 20353 184614 63284051
Agranulocytosis 43.98 17.96 47 20310 25087 63443578
Acute graft versus host disease 42.49 17.96 23 20334 4405 63464260
Hepatosplenic candidiasis 42.34 17.96 11 20346 260 63468405
Drug reaction with eosinophilia and systemic symptoms 41.96 17.96 53 20304 33783 63434882
Cytomegalovirus test positive 41.55 17.96 20 20337 2998 63465667
Disseminated intravascular coagulation 41.31 17.96 40 20317 19011 63449654
Wound 40.83 17.96 3 20354 163260 63305405
Pneumonia moraxella 40.81 17.96 8 20349 48 63468617
Blood bilirubin increased 39.59 17.96 54 20303 37086 63431579
Hepatic function abnormal 39.58 17.96 54 20303 37088 63431577
Pulmonary haemorrhage 39.34 17.96 26 20331 7155 63461510
Discomfort 39.34 17.96 4 20353 167370 63301295
Acute myeloid leukaemia recurrent 39.34 17.96 16 20341 1607 63467058
Anxiety 38.52 17.96 11 20346 217530 63251135
Cardiac arrest 38.52 17.96 89 20268 92456 63376209
Circulatory collapse 38.34 17.96 41 20316 21897 63446768
Meningitis cryptococcal 38.33 17.96 15 20342 1362 63467303
Pyelonephritis fungal 38.26 17.96 9 20348 139 63468526
Endophthalmitis 38.25 17.96 20 20337 3572 63465093
Chronic graft versus host disease 38.05 17.96 19 20338 3083 63465582
Systemic lupus erythematosus 38.05 17.96 10 20347 208908 63259757
Emphysematous pyelonephritis 37.33 17.96 10 20347 267 63468398
Gamma-glutamyltransferase increased 37.06 17.96 50 20307 33981 63434684
Rhinocerebral mucormycosis 36.46 17.96 11 20346 454 63468211
Alanine aminotransferase increased 35.95 17.96 93 20264 103677 63364988
Electrolyte imbalance 35.93 17.96 38 20319 20038 63448627
General physical health deterioration 35.41 17.96 143 20214 201259 63267406
Premature delivery 35.30 17.96 46 20311 30235 63438430
Neutropenic colitis 35.16 17.96 18 20339 3077 63465588
Drug hypersensitivity 34.95 17.96 29 20328 310658 63158007
Bone marrow failure 34.93 17.96 45 20312 29245 63439420
Pain in extremity 34.82 17.96 33 20324 331453 63137212
Fungal test positive 34.41 17.96 11 20346 551 63468114
Pancreatitis acute 34.40 17.96 43 20314 27123 63441542
Central nervous system fungal infection 34.10 17.96 8 20349 122 63468543
Encephalopathy 33.61 17.96 51 20306 38569 63430096
Acute graft versus host disease in skin 33.31 17.96 18 20339 3434 63465231
Graft versus host disease in skin 33.31 17.96 17 20340 2888 63465777
Respiratory disorder 33.15 17.96 51 20306 39031 63429634
Drug interaction 32.86 17.96 153 20204 228978 63239687
Graft versus host disease in liver 32.72 17.96 11 20346 646 63468019
Staphylococcal infection 32.45 17.96 52 20305 41204 63427461
Trichosporon infection 32.19 17.96 9 20348 283 63468382
Keratitis fungal 32.11 17.96 8 20349 159 63468506
Brain oedema 31.14 17.96 30 20327 14165 63454500
Hepatic cytolysis 30.89 17.96 31 20326 15376 63453289
Back pain 30.52 17.96 24 20333 264121 63204544
Disseminated aspergillosis 30.46 17.96 7 20350 97 63468568
Cerebral fungal infection 30.26 17.96 7 20350 100 63468565
Cryptococcosis 30.09 17.96 12 20345 1145 63467520
Hypoxia 29.99 17.96 62 20295 59730 63408935
Acute myeloid leukaemia 29.88 17.96 32 20325 17115 63451550
Immunosuppressant drug level increased 29.72 17.96 17 20340 3621 63465044
Insomnia 29.70 17.96 16 20341 215236 63253429
Contusion 29.66 17.96 6 20351 150038 63318627
Depression 29.55 17.96 13 20344 196479 63272186
Dyspnoea 29.45 17.96 111 20246 661202 62807463
Hypertransaminasaemia 29.29 17.96 21 20336 6588 63462077
Lower respiratory tract infection 29.01 17.96 4 20353 132303 63336362
Klebsiella infection 28.64 17.96 23 20334 8543 63460122
Capillary leak syndrome 28.54 17.96 14 20343 2186 63466479
Weight increased 28.52 17.96 25 20332 260767 63207898
Bacterial sepsis 28.39 17.96 17 20340 3941 63464724
Mixed liver injury 28.04 17.96 18 20339 4717 63463948
Liver abscess 27.87 17.96 15 20342 2839 63465826
Cardiac valve vegetation 27.65 17.96 8 20349 285 63468380
Status epilepticus 27.56 17.96 29 20328 15204 63453461
Staphylococcal sepsis 27.55 17.96 22 20335 8106 63460559
Aplasia 27.24 17.96 17 20340 4242 63464423
Asthenia 27.23 17.96 51 20306 383553 63085112
Eosinophilia 27.19 17.96 35 20322 22721 63445944
Disease progression 26.40 17.96 93 20264 122665 63346000
Brain abscess 26.06 17.96 13 20344 2105 63466560
Human herpesvirus 6 infection reactivation 25.73 17.96 8 20349 366 63468299
Sinusitis 25.67 17.96 21 20336 226632 63242033
Overgrowth fungal 25.61 17.96 6 20351 91 63468574
Pneumonia cytomegaloviral 25.51 17.96 13 20344 2201 63466464
Flavobacterium infection 25.41 17.96 4 20353 4 63468661
Streptococcal bacteraemia 25.14 17.96 12 20345 1765 63466900
Herpes simplex 25.11 17.96 21 20336 8250 63460415
Gastrointestinal mucormycosis 24.83 17.96 7 20350 227 63468438
Acute respiratory distress syndrome 24.75 17.96 34 20323 23500 63445165
Gait disturbance 24.71 17.96 14 20343 183164 63285501
Escherichia infection 24.36 17.96 25 20332 12729 63455936
Arthritis 24.28 17.96 4 20353 115917 63352748
Respiratory distress 24.28 17.96 41 20316 33910 63434755
Intestinal infarction 24.25 17.96 10 20347 1040 63467625
Bone marrow transplant 23.94 17.96 9 20348 733 63467932
Feeling abnormal 23.63 17.96 9 20348 148383 63320282
Necrosis 23.33 17.96 17 20340 5470 63463195
Coagulation test abnormal 23.30 17.96 9 20348 789 63467876
Platelet count decreased 23.29 17.96 86 20271 116036 63352629
Renal tubular disorder 23.17 17.96 13 20344 2669 63465996
Urinary tract infection enterococcal 23.03 17.96 13 20344 2700 63465965
Renal tubular acidosis 22.65 17.96 11 20346 1681 63466984
Hepatitis fulminant 22.59 17.96 14 20343 3450 63465215
Hypercreatininaemia 22.40 17.96 8 20349 563 63468102
Pulmonary mucormycosis 22.39 17.96 7 20350 326 63468339
Acute graft versus host disease in intestine 22.30 17.96 11 20346 1738 63466927
Septic embolus 22.28 17.96 9 20348 888 63467777
Septal panniculitis 22.13 17.96 5 20352 64 63468601
Idiopathic pneumonia syndrome 21.85 17.96 7 20350 353 63468312
Metabolic acidosis 21.74 17.96 46 20311 45023 63423642
Pseudomonal sepsis 21.73 17.96 12 20345 2389 63466276
Immune reconstitution inflammatory syndrome associated tuberculosis 21.66 17.96 7 20350 363 63468302
Delivery 21.47 17.96 10 20347 1393 63467272
Tachypnoea 21.29 17.96 27 20330 17275 63451390
Bacteraemia 21.23 17.96 27 20330 17321 63451344
Upper airway necrosis 21.14 17.96 3 20354 0 63468665
Nervous system disorder 21.08 17.96 28 20329 18738 63449927
Hemianopia homonymous 21.06 17.96 8 20349 670 63467995
Atrioventricular block second degree 21.03 17.96 14 20343 3900 63464765
Blood pressure increased 20.99 17.96 13 20344 162049 63306616
Infective aneurysm 20.97 17.96 7 20350 402 63468263
Muscle spasms 20.96 17.96 12 20345 156138 63312527
Pericarditis 20.92 17.96 8 20349 131571 63337094
Septic pulmonary embolism 20.92 17.96 5 20352 83 63468582
Hypersensitivity 20.67 17.96 39 20318 292646 63176019
Hypoproteinaemia 20.66 17.96 11 20346 2038 63466627
Vesicoureteric reflux 20.63 17.96 6 20351 218 63468447
Transplant rejection 20.35 17.96 21 20336 10759 63457906
Foetal malnutrition 20.23 17.96 5 20352 96 63468569
Foetal anaemia 20.18 17.96 5 20352 97 63468568
Bulimia nervosa 19.96 17.96 7 20350 467 63468198
Hyperthyroidism 19.82 17.96 24 20333 14649 63454016
Orthostatic intolerance 19.78 17.96 9 20348 1188 63467477
Tumour lysis syndrome 19.72 17.96 19 20338 8971 63459694
Sweat gland tumour 19.67 17.96 5 20352 108 63468557
Bronchial anastomosis complication 19.63 17.96 4 20353 30 63468635
Hypomagnesaemia 19.62 17.96 34 20323 28703 63439962
Pleural effusion 19.50 17.96 70 20287 93140 63375525
Pneumothorax 19.41 17.96 25 20332 16236 63452429
Haemorrhagic disorder 19.26 17.96 8 20349 848 63467817
Pruritus 19.25 17.96 56 20301 361397 63107268
Pythium insidiosum infection 19.06 17.96 3 20354 3 63468662
Infective glossitis 18.98 17.96 4 20353 36 63468629
Sinusitis fungal 18.94 17.96 10 20347 1821 63466844
Abdominal pain upper 18.93 17.96 23 20334 206421 63262244
Herpes zoster meningoencephalitis 18.82 17.96 6 20351 298 63468367
Meningitis bacterial 18.64 17.96 9 20348 1358 63467307
Neurotoxicity 18.55 17.96 25 20332 16965 63451700
Gastrooesophageal reflux disease 18.54 17.96 4 20353 95635 63373030
Eye infection fungal 18.47 17.96 5 20352 139 63468526
Hepatic necrosis 18.44 17.96 15 20342 5672 63462993
Venoocclusive liver disease 18.36 17.96 14 20343 4821 63463844
Hepatocellular injury 18.18 17.96 32 20325 27349 63441316
Urinary tract stoma complication 18.18 17.96 4 20353 45 63468620
Klebsiella sepsis 18.11 17.96 9 20348 1446 63467219
Anaemia 18.09 17.96 158 20199 293272 63175393
Hepatotoxicity 18.09 17.96 38 20319 37003 63431662
Blood cholesterol increased 18.09 17.96 4 20353 94028 63374637

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 778.05 14.16 1433 30223 455318 34469957
Multiple organ dysfunction syndrome 313.64 14.16 366 31290 76200 34849075
Aspergillus infection 305.45 14.16 170 31486 12084 34913191
Immune reconstitution inflammatory syndrome 214.12 14.16 120 31536 8639 34916636
Mucormycosis 206.57 14.16 103 31553 5839 34919436
Choroiditis 169.16 14.16 57 31599 1158 34924117
Hypokalaemia 163.52 14.16 231 31425 57983 34867292
Drug resistance 155.64 14.16 152 31504 25775 34899500
Bronchopulmonary aspergillosis 153.26 14.16 118 31538 14541 34910734
Cerebral aspergillosis 144.99 14.16 53 31603 1379 34923896
Nephropathy toxic 135.25 14.16 103 31553 12485 34912790
Septic shock 129.78 14.16 233 31423 71601 34853674
Fatigue 126.83 14.16 91 31565 370562 34554713
Fall 113.34 14.16 23 31633 202862 34722413
Fungal infection 108.13 14.16 100 31556 15835 34909440
Respiratory failure 102.56 14.16 271 31385 108301 34816974
Drug ineffective for unapproved indication 101.27 14.16 116 31540 23599 34901676
Graft versus host disease 99.51 14.16 80 31576 10489 34914786
Hepatosplenomegaly 98.84 14.16 56 31600 4113 34921162
Product dose omission issue 94.82 14.16 3 31653 119708 34805567
Asthenia 89.38 14.16 56 31600 245195 34680080
Trichosporon infection 88.79 14.16 31 31625 703 34924572
Uveitis 88.39 14.16 65 31591 7470 34917805
Systemic mycosis 88.23 14.16 38 31618 1535 34923740
Off label use 87.38 14.16 663 30993 418861 34506414
Disseminated intravascular coagulation 85.30 14.16 102 31554 21714 34903561
Renal impairment 85.28 14.16 232 31424 94281 34830994
Febrile neutropenia 82.64 14.16 292 31364 136557 34788718
Condition aggravated 81.44 14.16 367 31289 191829 34733446
Pneumonia fungal 80.48 14.16 60 31596 7040 34918235
Meningitis cryptococcal 78.64 14.16 40 31616 2364 34922911
Arthralgia 78.51 14.16 28 31628 170013 34755262
Intraocular pressure increased 78.38 14.16 53 31603 5330 34919945
Pyrexia 76.48 14.16 539 31117 332474 34592801
Fungaemia 76.15 14.16 40 31616 2528 34922747
Fungal endocarditis 74.00 14.16 23 31633 357 34924918
Sepsis 73.50 14.16 322 31334 166239 34759036
Cryptococcosis 72.64 14.16 38 31618 2381 34922894
Death 69.52 14.16 162 31494 397887 34527388
Fusarium infection 68.29 14.16 29 31627 1131 34924144
Eye pain 68.12 14.16 72 31584 13390 34911885
Nephrogenic diabetes insipidus 67.87 14.16 30 31626 1291 34923984
Systemic candida 67.30 14.16 42 31614 3684 34921591
Pathogen resistance 67.23 14.16 61 31595 9421 34915854
Haemophagocytic lymphohistiocytosis 66.74 14.16 70 31586 12903 34912372
Cytomegalovirus infection 65.00 14.16 98 31558 26037 34899238
Rectal prolapse 64.24 14.16 22 31634 470 34924805
Disseminated cryptococcosis 63.33 14.16 29 31627 1357 34923918
Pancytopenia 61.70 14.16 208 31448 94949 34830326
Delayed graft function 61.35 14.16 33 31623 2188 34923087
Intracranial pressure increased 60.13 14.16 40 31616 3915 34921360
Renal cyst haemorrhage 58.62 14.16 22 31634 617 34924658
Scedosporium infection 58.48 14.16 24 31632 858 34924417
Pain in extremity 58.08 14.16 21 31635 126492 34798783
Blood creatinine increased 57.56 14.16 203 31453 94773 34830502
Central nervous system lesion 56.79 14.16 47 31609 6416 34918859
Nausea 55.61 14.16 143 31513 339765 34585510
Intraductal papillary mucinous neoplasm 54.90 14.16 20 31636 515 34924760
Peripheral swelling 53.97 14.16 4 31652 76537 34848738
Drug abuse 53.69 14.16 12 31644 99084 34826191
Encephalitis 51.95 14.16 47 31609 7230 34918045
Cholestasis 51.93 14.16 90 31566 26858 34898417
Myocardial infarction 50.85 14.16 23 31633 121062 34804213
Candida infection 49.22 14.16 70 31586 17645 34907630
Abdominal wall haemorrhage 49.10 14.16 18 31638 472 34924803
Malaise 48.69 14.16 58 31598 185767 34739508
Product use in unapproved indication 47.88 14.16 222 31434 117277 34807998
SARS-CoV-2 antibody test positive 47.83 14.16 17 31639 407 34924868
Vena cava injury 47.52 14.16 16 31640 324 34924951
Acute kidney injury 46.35 14.16 450 31206 304538 34620737
Renal failure 46.27 14.16 237 31419 130320 34794955
Constipation 46.17 14.16 34 31622 136948 34788327
Necrotising retinitis 46.11 14.16 20 31636 822 34924453
Visual acuity reduced 45.14 14.16 64 31592 16085 34909190
Actinic keratosis 43.90 14.16 35 31621 4532 34920743
Dizziness 43.86 14.16 82 31574 218439 34706836
Pulmonary haemorrhage 43.29 14.16 50 31606 10254 34915021
Nasopharyngitis 43.27 14.16 6 31650 69962 34855313
Anxiety 43.14 14.16 18 31638 99410 34825865
Oroantral fistula 42.12 14.16 13 31643 197 34925078
Vascular anastomotic haemorrhage 42.07 14.16 14 31642 273 34925002
Pain 41.78 14.16 76 31580 204599 34720676
Hypofibrinogenaemia 40.92 14.16 23 31633 1663 34923612
Feeling abnormal 40.12 14.16 5 31651 63230 34862045
Brain abscess 39.02 14.16 28 31628 3097 34922178
Perineal cyst 38.81 14.16 13 31643 259 34925016
Splenic embolism 38.57 14.16 12 31644 187 34925088
Fungal skin infection 38.50 14.16 26 31630 2608 34922667
Depression 38.39 14.16 20 31636 97078 34828197
Acute graft versus host disease in skin 37.93 14.16 34 31622 5167 34920108
Dyspnoea 37.45 14.16 195 31461 376587 34548688
Joint swelling 37.35 14.16 5 31651 59885 34865390
Dehiscence 36.28 14.16 10 31646 99 34925176
Carotid arteriosclerosis 36.25 14.16 22 31634 1836 34923439
Hepatosplenic candidiasis 36.06 14.16 12 31644 234 34925041
Pseudomonas infection 35.99 14.16 50 31606 12332 34912943
Osteomyelitis fungal 35.73 14.16 12 31644 241 34925034
Septic embolus 35.51 14.16 19 31637 1246 34924029
Diarrhoea 35.36 14.16 208 31448 389704 34535571
Vascular compression 34.69 14.16 13 31643 363 34924912
Renal artery stenosis 34.69 14.16 23 31633 2238 34923037
Aspergillus test positive 34.63 14.16 14 31642 481 34924794
Eye infection fungal 34.56 14.16 13 31643 367 34924908
Gait disturbance 34.46 14.16 17 31639 85123 34840152
Diaphragmatic injury 34.09 14.16 10 31646 126 34925149
Enterococcal infection 33.91 14.16 42 31614 9264 34916011
Chest pain 33.78 14.16 39 31617 126723 34798552
Muscle spasms 33.47 14.16 13 31643 74988 34850287
Acute respiratory distress syndrome 33.25 14.16 73 31583 25896 34899379
Cardiac failure congestive 33.14 14.16 17 31639 83253 34842022
Abdominal discomfort 32.90 14.16 7 31649 59828 34865447
Treatment failure 32.84 14.16 105 31551 46592 34878683
Leukopenia 32.73 14.16 128 31528 62728 34862547
General physical health deterioration 32.46 14.16 213 31443 128056 34797219
Tooth deposit 32.31 14.16 9 31647 93 34925182
Varicella zoster virus infection 31.72 14.16 20 31636 1786 34923489
Blood bilirubin increased 31.52 14.16 91 31565 38205 34887070
Aortic dilatation 31.02 14.16 18 31638 1383 34923892
Disseminated mucormycosis 30.14 14.16 13 31643 527 34924748
Mucosal inflammation 30.09 14.16 90 31566 38532 34886743
Polyomavirus-associated nephropathy 29.77 14.16 26 31630 3818 34921457
Activated partial thromboplastin time prolonged 29.70 14.16 38 31618 8657 34916618
Bone marrow failure 29.58 14.16 75 31581 29178 34896097
Hyperhidrosis 29.31 14.16 16 31640 75676 34849599
Cerebral cyst 29.29 14.16 11 31645 309 34924966
Leishmaniasis 28.90 14.16 11 31645 321 34924954
Musculoskeletal stiffness 28.86 14.16 4 31652 46676 34878599
Intentional overdose 28.83 14.16 3 31653 43671 34881604
Graft versus host disease in gastrointestinal tract 28.70 14.16 25 31631 3658 34921617
Liver transplant failure 28.02 14.16 8 31648 91 34925184
Intentional product misuse 27.99 14.16 4 31652 45607 34879668
Congenital pneumonia 27.79 14.16 8 31648 94 34925181
Sideroblastic anaemia 27.76 14.16 10 31646 249 34925026
Complications of transplanted kidney 27.59 14.16 27 31629 4582 34920693
Therapy non-responder 27.51 14.16 88 31568 39058 34886217
Infection in an immunocompromised host 27.47 14.16 13 31643 656 34924619
Blood 25-hydroxycholecalciferol decreased 27.39 14.16 10 31646 259 34925016
Pneumonia pseudomonal 27.35 14.16 25 31631 3897 34921378
Neurological decompensation 26.96 14.16 22 31634 2944 34922331
Hyperparathyroidism secondary 26.63 14.16 17 31639 1551 34923724
Acute graft versus host disease in intestine 26.56 14.16 21 31635 2687 34922588
Swelling of eyelid 26.54 14.16 15 31641 1096 34924179
Chronic obstructive pulmonary disease 26.33 14.16 6 31650 48912 34876363
Periostitis 26.08 14.16 10 31646 298 34924977
Bacterial pericarditis 25.80 14.16 7 31649 65 34925210
Mean cell volume increased 25.69 14.16 22 31634 3147 34922128
Somnolence 25.68 14.16 38 31618 111078 34814197
Insomnia 25.54 14.16 34 31622 103873 34821402
Vitamin B1 decreased 25.17 14.16 10 31646 328 34924947
Psoriasis 24.78 14.16 3 31653 38809 34886466
Adenovirus infection 24.63 14.16 27 31629 5230 34920045
Blood alkaline phosphatase increased 24.62 14.16 73 31583 31102 34894173
Intervertebral disc space narrowing 24.54 14.16 14 31642 1041 34924234
Rash 24.54 14.16 111 31545 222641 34702634
Hepatic function abnormal 24.45 14.16 92 31564 44271 34881004
Moraxella infection 24.44 14.16 9 31647 239 34925036
Inappropriate schedule of product administration 24.36 14.16 13 31643 62283 34862992
Abscess fungal 24.03 14.16 9 31647 251 34925024
Dyspnoea exertional 23.92 14.16 5 31651 43274 34882001
Weight decreased 23.79 14.16 81 31575 176220 34749055
Hepatotoxicity 23.75 14.16 57 31599 21428 34903847
Retinitis viral 23.67 14.16 7 31649 91 34925184
Pulmonary mass 23.65 14.16 42 31614 12770 34912505
Gamma-glutamyltransferase increased 23.61 14.16 69 31587 29162 34896113
Organic brain syndrome 23.51 14.16 9 31647 267 34925008
Toxic epidermal necrolysis 23.47 14.16 57 31599 21589 34903686
Blood glucose increased 23.19 14.16 16 31640 66702 34858573
Diverticulum intestinal 23.04 14.16 23 31633 3998 34921277
Urticaria 22.99 14.16 14 31642 62363 34862912
Scopulariopsis infection 22.93 14.16 7 31649 102 34925173
Pulpitis dental 22.60 14.16 11 31645 591 34924684
C-reactive protein increased 22.58 14.16 103 31553 53995 34871280
Incorrect product formulation administered 22.43 14.16 5 31651 18 34925257
Back pain 22.42 14.16 48 31608 121741 34803534
Mycobacterial infection 22.40 14.16 18 31638 2356 34922919
Granulomatous liver disease 22.34 14.16 11 31645 606 34924669
Splenic infarction 22.32 14.16 17 31639 2058 34923217
Muscle abscess 22.29 14.16 11 31645 609 34924666
Deep vein thrombosis 22.21 14.16 16 31640 65232 34860043
Epileptic encephalopathy 22.18 14.16 8 31648 200 34925075
Pruritus 22.16 14.16 61 31595 141920 34783355
Escherichia infection 22.05 14.16 32 31624 8213 34917062
Rheumatoid arthritis 22.01 14.16 4 31652 38234 34887041
Fluorosis 21.99 14.16 6 31650 57 34925218
Memory impairment 21.98 14.16 6 31650 43312 34881963
Toxoplasmosis 21.69 14.16 14 31642 1302 34923973
Blood pressure increased 21.48 14.16 29 31627 88073 34837202
Therapeutic product effect decreased 21.43 14.16 3 31653 34740 34890535
Venoocclusive disease 21.42 14.16 19 31637 2848 34922427
Pulmonary embolism 21.42 14.16 30 31626 89716 34835559
Shock 21.40 14.16 59 31597 24120 34901155
Febrile infection 21.37 14.16 17 31639 2194 34923081
Abdominal pain upper 21.28 14.16 20 31636 71470 34853805
Central nervous system vasculitis 21.23 14.16 10 31646 499 34924776
Serratia infection 21.19 14.16 12 31644 880 34924395
Capillary leak syndrome 21.05 14.16 17 31639 2241 34923034
Optic discs blurred 21.04 14.16 6 31650 68 34925207
Dyspepsia 20.80 14.16 4 31652 36728 34888547
Toxicity to various agents 20.79 14.16 102 31554 200260 34725015
Suicide attempt 20.65 14.16 5 31651 39111 34886164
Retinal ischaemia 20.56 14.16 9 31647 378 34924897
Acute lymphocytic leukaemia 20.52 14.16 19 31637 3010 34922265
Contusion 20.51 14.16 4 31652 36360 34888915
Product use issue 20.46 14.16 112 31544 63104 34862171
Syncope 20.43 14.16 32 31624 91419 34833856
Liver disorder 20.36 14.16 71 31585 32926 34892349
Troponin T increased 20.33 14.16 17 31639 2354 34922921
Aortic arteriosclerosis 20.32 14.16 23 31633 4613 34920662
Loss of personal independence in daily activities 20.15 14.16 3 31653 33176 34892099
Hypoalbuminaemia 20.06 14.16 38 31618 12136 34913139
Cardiac disorder 20.04 14.16 7 31649 43119 34882156
Venoocclusive liver disease 19.98 14.16 30 31626 7936 34917339
Serratia sepsis 19.94 14.16 6 31650 83 34925192
Graft versus host disease in skin 19.86 14.16 21 31635 3904 34921371
Unevaluable event 19.67 14.16 3 31653 32587 34892688
Bacterial infection 19.65 14.16 46 31610 17017 34908258
Rectal haemorrhage 19.64 14.16 6 31650 40243 34885032
Drug level increased 19.64 14.16 54 31602 22042 34903233
Infective aneurysm 19.59 14.16 10 31646 595 34924680
ADAMTS13 activity decreased 19.56 14.16 6 31650 89 34925186
Acute graft versus host disease in liver 19.48 14.16 14 31642 1552 34923723
Lower respiratory tract infection fungal 19.39 14.16 10 31646 608 34924667
Granuloma 19.38 14.16 19 31637 3232 34922043
Blastomycosis 19 14.16 9 31647 455 34924820
Hyperbilirubinaemia 18.95 14.16 45 31611 16798 34908477
Histoplasmosis disseminated 18.84 14.16 13 31643 1350 34923925
Organising pneumonia 18.67 14.16 25 31631 5954 34919321
Acute myeloid leukaemia 18.63 14.16 47 31609 18223 34907052
Cardiac valve vegetation 18.52 14.16 9 31647 482 34924793
Hypoaesthesia 18.51 14.16 17 31639 61427 34863848
Vomiting 18.40 14.16 140 31516 247481 34677794
International normalised ratio increased 18.32 14.16 10 31646 47317 34877958
Vitamin D decreased 18.31 14.16 19 31637 3457 34921818
Geotrichum infection 18.29 14.16 9 31647 495 34924780
Mediastinitis 18.27 14.16 10 31646 686 34924589
Urinary tract infection 18.23 14.16 30 31626 84051 34841224
Bacterial disease carrier 18.12 14.16 9 31647 505 34924770
Drug therapeutic incompatibility 18.08 14.16 6 31650 116 34925159
Bacterial sepsis 18.02 14.16 23 31633 5227 34920048
Neutropenia 17.99 14.16 219 31437 156559 34768716
Coagulation factor VII level decreased 17.94 14.16 6 31650 119 34925156
Respiratory tract infection fungal 17.87 14.16 10 31646 717 34924558
Skin mass 17.86 14.16 20 31636 3965 34921310
Cardiac pacemaker evaluation 17.71 14.16 6 31650 124 34925151
Weight increased 17.68 14.16 36 31620 92997 34832278
Carotid artery insufficiency 17.61 14.16 4 31652 16 34925259
Skin necrosis 17.55 14.16 24 31632 5829 34919446
Urge incontinence 17.55 14.16 9 31647 541 34924734
Drug intolerance 17.34 14.16 17 31639 59553 34865722
Thrombotic microangiopathy 17.29 14.16 33 31623 10597 34914678
Hepatitis cholestatic 17.24 14.16 28 31628 7919 34917356
Drug hypersensitivity 17.21 14.16 29 31627 80500 34844775
Aplasia 17.19 14.16 21 31635 4567 34920708
Gallbladder polyp 17.16 14.16 8 31648 390 34924885
Acute graft versus host disease 17.04 14.16 25 31631 6478 34918797
Renal tubular disorder 16.98 14.16 21 31635 4622 34920653
CARD9 deficiency 16.88 14.16 4 31652 20 34925255
Neuropathy peripheral 16.88 14.16 31 31625 83232 34842043
Pruritus allergic 16.70 14.16 7 31649 264 34925011
Pneumonia cytomegaloviral 16.64 14.16 17 31639 3037 34922238
Balance disorder 16.62 14.16 8 31648 40646 34884629
Staphylococcal sepsis 16.56 14.16 31 31625 9813 34915462
Asthma 16.53 14.16 9 31647 42647 34882628
Dry skin 16.51 14.16 4 31652 31283 34893992
Torsade de pointes 16.47 14.16 26 31630 7183 34918092
Spinal stenosis 16.40 14.16 22 31634 5247 34920028
Endophthalmitis 16.40 14.16 18 31638 3490 34921785
Pleural effusion 16.30 14.16 128 31528 81418 34843857
Meningitis 16.27 14.16 21 31635 4826 34920449
Fungal sepsis 16.26 14.16 10 31646 854 34924421
Eye abscess 16.20 14.16 6 31650 162 34925113
Productive cough 16.14 14.16 7 31649 37806 34887469
Chondritis 16.13 14.16 6 31650 164 34925111
Brain herniation 16.09 14.16 19 31637 3989 34921286
Generalised oedema 16.01 14.16 35 31621 12373 34912902
Upper respiratory tract infection 16.00 14.16 5 31651 33054 34892221
Ecthyma 15.86 14.16 8 31648 464 34924811
Bladder hypertrophy 15.82 14.16 9 31647 666 34924609
Bladder spasm 15.77 14.16 10 31646 902 34924373
Confusional state 15.76 14.16 72 31584 144088 34781187
Intracranial mass 15.70 14.16 11 31645 1171 34924104
Renal tubular necrosis 15.64 14.16 40 31616 15640 34909635
Encephalitis brain stem 15.61 14.16 5 31651 86 34925189
Squamous cell carcinoma of skin 15.55 14.16 32 31624 10849 34914426
Splenomegaly 15.53 14.16 39 31617 15078 34910197
Mediastinal shift 15.49 14.16 3 31653 4 34925271
Intervertebral discitis 15.32 14.16 14 31642 2181 34923094
Patent ductus arteriosus 15.32 14.16 17 31639 3337 34921938
Escherichia sepsis 15.19 14.16 20 31636 4684 34920591
Cerebrovascular accident 15.13 14.16 34 31622 84777 34840498
Obliterative bronchiolitis 15.12 14.16 11 31645 1242 34924033
Arthropathy 15.09 14.16 3 31653 26904 34898371
Haematochezia 15.08 14.16 12 31644 46522 34878753
Pulmonary interstitial emphysema syndrome 15.08 14.16 8 31648 516 34924759
Enterococcal bacteraemia 15.03 14.16 13 31643 1884 34923391
Hydrocephalus 15.01 14.16 21 31635 5211 34920064
Neurotoxicity 15.01 14.16 43 31613 17967 34907308
Drug level decreased 14.84 14.16 26 31630 7820 34917455
Amnesia 14.82 14.16 3 31653 26560 34898715
Chronic graft versus host disease 14.76 14.16 19 31637 4354 34920921
Vision blurred 14.71 14.16 12 31644 45951 34879324
Periodontitis 14.71 14.16 13 31643 1939 34923336
Mucosal haemorrhage 14.66 14.16 12 31644 1613 34923662
Fungal test positive 14.60 14.16 8 31648 550 34924725
Brain oedema 14.56 14.16 36 31620 13785 34911490
Encephalopathy 14.55 14.16 67 31589 35252 34890023
Lung transplant rejection 14.49 14.16 9 31647 783 34924492
Laryngitis fungal 14.48 14.16 4 31652 40 34925235
CD4 lymphocytes increased 14.47 14.16 6 31650 220 34925055
Glutathione synthetase deficiency 14.42 14.16 3 31653 7 34925268
Graft complication 14.40 14.16 7 31649 375 34924900
Abdominal pain 14.38 14.16 88 31568 163530 34761745
Orthostatic hypotension 14.31 14.16 3 31653 25916 34899359
Periodontal disease 14.28 14.16 9 31647 803 34924472
Blast cell count increased 14.24 14.16 10 31646 1068 34924207
Device related infection 14.21 14.16 41 31615 17196 34908079
Blindness unilateral 14.19 14.16 19 31637 4523 34920752
Transfusion-related acute lung injury 14.17 14.16 5 31651 117 34925158

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 1166.93 14.13 2198 45414 1078715 78618061
Multiple organ dysfunction syndrome 735.84 14.13 594 47018 119652 79577124
Aspergillus infection 508.54 14.13 242 47370 18919 79677857
Mucormycosis 443.50 14.13 173 47439 8296 79688480
Immune reconstitution inflammatory syndrome 346.56 14.13 168 47444 13673 79683103
Septic shock 321.20 14.13 381 47231 122420 79574356
Bronchopulmonary aspergillosis 312.87 14.13 184 47428 22110 79674666
Fatigue 270.78 14.13 109 47503 929618 78767158
Hypokalaemia 261.15 14.13 373 47239 143667 79553109
Respiratory failure 228.66 14.13 397 47215 180514 79516262
Nephropathy toxic 211.65 14.13 139 47473 20280 79676496
Arthralgia 192.43 14.13 52 47560 571751 79125025
Drug resistance 189.55 14.13 175 47437 42038 79654738
Febrile neutropenia 185.35 14.13 419 47193 230580 79466196
Renal impairment 179.74 14.13 331 47281 157452 79539324
Choroiditis 176.87 14.13 55 47557 1326 79695450
Drug ineffective for unapproved indication 175.18 14.13 183 47429 51055 79645721
Sepsis 174.66 14.13 450 47162 268978 79427798
Systemic mycosis 174.05 14.13 64 47548 2602 79694174
Pathogen resistance 171.88 14.13 107 47505 14235 79682541
Pneumonia fungal 171.80 14.13 98 47514 11112 79685664
Cerebral aspergillosis 166.61 14.13 56 47556 1740 79695036
Pain 161.12 14.13 112 47500 703690 78993086
Fall 157.24 14.13 48 47564 487581 79209195
Fungal infection 157.04 14.13 157 47455 41591 79655185
Acute kidney injury 153.74 14.13 665 46947 518739 79178037
Haemophagocytic lymphohistiocytosis 148.51 14.13 115 47497 21722 79675054
Systemic candida 145.90 14.13 74 47538 6632 79690144
Off label use 142.96 14.13 977 46635 906238 78790538
Peripheral swelling 142.46 14.13 4 47608 269613 79427163
Fungaemia 140.41 14.13 64 47548 4527 79692249
Joint swelling 140.06 14.13 8 47604 288638 79408138
Graft versus host disease 138.23 14.13 95 47517 14931 79681845
Renal failure 136.72 14.13 342 47270 200626 79496150
Pancytopenia 134.34 14.13 302 47310 165443 79531333
Pyrexia 128.99 14.13 767 46845 677942 79018834
Cytomegalovirus infection 125.94 14.13 141 47471 42503 79654273
Fungal endocarditis 120.39 14.13 34 47578 580 79696196
Meningitis cryptococcal 120.39 14.13 53 47559 3453 79693323
Hepatosplenomegaly 117.72 14.13 62 47550 6007 79690769
Trichosporon infection 116.01 14.13 37 47575 971 79695805
Product dose omission issue 113.81 14.13 9 47603 247528 79449248
Toxic epidermal necrolysis 110.94 14.13 135 47477 44446 79652330
Candida infection 108.83 14.13 124 47488 38090 79658686
Disseminated intravascular coagulation 108.40 14.13 120 47492 35722 79661054
Cryptococcosis 107.79 14.13 49 47563 3444 79693332
Product use in unapproved indication 106.37 14.13 360 47252 249999 79446777
Cholestasis 104.83 14.13 142 47470 51967 79644809
Nasopharyngitis 104.43 14.13 14 47598 253867 79442909
Dizziness 102.60 14.13 98 47514 526343 79170433
Scedosporium infection 102.13 14.13 37 47575 1441 79695335
Rheumatoid arthritis 100.42 14.13 6 47606 208464 79488312
Malaise 99.23 14.13 88 47524 489781 79206995
Asthenia 98.84 14.13 96 47516 511593 79185183
Neutropenia 98.78 14.13 386 47226 287324 79409452
Fusarium infection 97.93 14.13 38 47574 1794 79694982
Abdominal discomfort 95.90 14.13 17 47595 250710 79446066
Pain in extremity 92.94 14.13 51 47561 364487 79332289
Enterococcal infection 88.48 14.13 74 47538 15586 79681190
Nephrogenic diabetes insipidus 85.57 14.13 36 47576 2098 79694678
Leukopenia 85.23 14.13 204 47408 116309 79580467
Musculoskeletal stiffness 81.45 14.13 6 47606 175002 79521774
Nausea 79.59 14.13 299 47313 956897 78739879
Hepatosplenic candidiasis 77.75 14.13 24 47588 564 79696212
Anxiety 77.25 14.13 26 47586 248486 79448290
Headache 77.06 14.13 173 47439 653599 79043177
Therapeutic product effect decreased 75.18 14.13 6 47606 163857 79532919
Drug intolerance 74.82 14.13 32 47580 264087 79432689
Mucosal inflammation 74.22 14.13 149 47463 75431 79621345
Drug level below therapeutic 72.03 14.13 54 47558 9716 79687060
Pseudomonas infection 72.02 14.13 75 47537 20828 79675948
Acute graft versus host disease in skin 71.81 14.13 49 47563 7609 79689167
Alopecia 70.53 14.13 25 47587 231330 79465446
Disseminated cryptococcosis 70.42 14.13 30 47582 1804 79694972
Uveitis 70.20 14.13 67 47545 16763 79680013
Brain abscess 69.91 14.13 41 47571 4895 79691881
Contraindicated product administered 68.95 14.13 7 47605 157531 79539245
Intraocular pressure increased 68.14 14.13 51 47561 9154 79687622
Candida sepsis 67.43 14.13 32 47580 2481 79694295
Pulmonary haemorrhage 66.01 14.13 61 47551 14656 79682120
Renal cyst haemorrhage 65.87 14.13 22 47590 670 79696106
Delayed graft function 65.68 14.13 35 47577 3472 79693304
Condition aggravated 65.47 14.13 517 47095 500607 79196169
Drug hypersensitivity 65.02 14.13 50 47562 298866 79397910
Drug level increased 64.95 14.13 98 47514 39553 79657223
Injection site pain 64.82 14.13 3 47609 129835 79566941
Dyspnoea 64.66 14.13 278 47334 856747 78840029
Histoplasmosis disseminated 63.25 14.13 30 47582 2323 79694453
Central nervous system lesion 63.07 14.13 57 47555 13311 79683465
General physical health deterioration 62.61 14.13 327 47285 274911 79421865
Contusion 61.64 14.13 8 47604 148768 79548008
Hepatic function abnormal 61.16 14.13 135 47477 72972 79623804
Blood creatinine increased 60.59 14.13 217 47395 154840 79541936
Rash maculo-papular 60.45 14.13 115 47497 55963 79640813
Mobility decreased 60.42 14.13 3 47609 122172 79574604
Depression 60.23 14.13 27 47585 216763 79480013
Drug abuse 60.12 14.13 12 47600 162679 79534097
Posterior reversible encephalopathy syndrome 59.63 14.13 76 47536 26205 79670571
Geotrichum infection 58.36 14.13 22 47590 959 79695817
Feeling abnormal 58.29 14.13 12 47600 159187 79537589
Septic embolus 57.75 14.13 27 47585 2024 79694752
Endophthalmitis 57.61 14.13 40 47572 6388 79690388
Blood bilirubin increased 57.33 14.13 124 47488 66108 79630668
Intracranial pressure increased 56.95 14.13 44 47568 8278 79688498
Visual acuity reduced 55.78 14.13 78 47534 29391 79667385
Graft versus host disease in gastrointestinal tract 55.67 14.13 39 47573 6317 79690459
Shock 55.45 14.13 96 47516 43452 79653324
Bone marrow failure 55.33 14.13 105 47507 51002 79645774
Intraductal papillary mucinous neoplasm 55.22 14.13 20 47592 778 79695998
Eye infection fungal 55.09 14.13 18 47594 511 79696265
Acute respiratory distress syndrome 54.62 14.13 96 47516 43971 79652805
Fungal sepsis 54.36 14.13 25 47587 1805 79694971
SARS-CoV-2 antibody test positive 54.19 14.13 17 47595 422 79696354
Abdominal wall haemorrhage 54.10 14.13 19 47593 675 79696101
Dehiscence 54.05 14.13 14 47598 169 79696607
Wound 54.00 14.13 4 47608 116175 79580601
Vena cava injury 53.53 14.13 16 47596 336 79696440
Encephalitis 52.73 14.13 54 47558 14706 79682070
Aplastic anaemia 52.50 14.13 59 47553 17846 79678930
Aspergillus test positive 51.98 14.13 19 47593 759 79696017
Pruritus 51.85 14.13 98 47514 394550 79302226
Gait disturbance 51.44 14.13 30 47582 207476 79489300
Acute graft versus host disease 51.23 14.13 45 47567 10122 79686654
Rash 50.32 14.13 177 47435 578181 79118595
Swelling 50.05 14.13 34 47578 216677 79480099
Necrotising retinitis 49.91 14.13 21 47591 1224 79695552
Asthma 49.84 14.13 10 47602 135085 79561691
Hyperbilirubinaemia 49.58 14.13 67 47545 24451 79672325
Loss of personal independence in daily activities 49.23 14.13 3 47609 102577 79594199
Abdominal pain upper 49.22 14.13 37 47575 223782 79472994
Weight increased 49.02 14.13 56 47556 277330 79419446
Disseminated mucormycosis 48.99 14.13 18 47594 730 79696046
Insomnia 48.41 14.13 45 47567 245125 79451651
Muscle spasms 48.15 14.13 22 47590 174708 79522068
Actinic keratosis 48.15 14.13 35 47577 6007 79690769
Infection in an immunocompromised host 48.01 14.13 21 47591 1347 79695429
Vascular anastomotic haemorrhage 47.82 14.13 14 47598 273 79696503
Osteomyelitis fungal 47.30 14.13 14 47598 284 79696492
Discomfort 46.96 14.13 9 47603 125608 79571168
Back pain 46.95 14.13 68 47544 304112 79392664
Chronic graft versus host disease 46.72 14.13 36 47576 6745 79690031
Arthritis 45.65 14.13 7 47605 114873 79581903
Acute graft versus host disease in intestine 45.53 14.13 29 47583 4012 79692764
Lower respiratory tract infection 44.77 14.13 11 47601 129209 79567567
Perineal cyst 44.28 14.13 13 47599 256 79696520
Escherichia infection 43.90 14.13 54 47558 17963 79678813
Blood pressure increased 43.88 14.13 37 47575 211323 79485453
Fungal skin infection 43.69 14.13 33 47579 6003 79690773
Brain oedema 43.61 14.13 64 47548 25199 79671577
Urticaria 42.83 14.13 29 47583 185172 79511604
Splenic embolism 42.75 14.13 12 47600 200 79696576
Acute myeloid leukaemia 41.85 14.13 70 47542 30815 79665961
Febrile bone marrow aplasia 41.81 14.13 45 47567 12975 79683801
Rectal prolapse 41.53 14.13 22 47590 2156 79694620
Central nervous system fungal infection 41.32 14.13 14 47598 446 79696330
Myocardial infarction 41.04 14.13 30 47582 184099 79512677
Encephalopathy 40.91 14.13 110 47502 67287 79629489
Migraine 40.69 14.13 3 47609 87490 79609286
Systemic lupus erythematosus 40.66 14.13 11 47601 121138 79575638
Thrombocytopenia 40.40 14.13 284 47328 264975 79431801
Gamma-glutamyltransferase increased 40.23 14.13 96 47516 54584 79642192
Therapy non-responder 40.23 14.13 134 47478 92171 79604605
Carotid arteriosclerosis 40.10 14.13 23 47589 2633 79694143
Acute myeloid leukaemia recurrent 39.92 14.13 25 47587 3358 79693418
Klebsiella infection 39.74 14.13 48 47564 15672 79681104
Rhinocerebral mucormycosis 39.61 14.13 17 47595 1041 79695735
Glossodynia 39.50 14.13 7 47605 103330 79593446
Leishmaniasis 39.39 14.13 13 47599 381 79696395
Somnolence 39.30 14.13 51 47561 238930 79457846
Diarrhoea 39.23 14.13 337 47275 880152 78816624
Psoriasis 39.14 14.13 4 47608 89583 79607193
Fungal test positive 39.03 14.13 17 47595 1079 79695697
Cardiac valve vegetation 38.52 14.13 16 47596 903 79695873
Diaphragmatic injury 38.22 14.13 10 47602 126 79696650
Eye pain 37.98 14.13 75 47537 37503 79659273
Pneumonia cytomegaloviral 37.83 14.13 28 47584 4941 79691835
Venoocclusive disease 37.61 14.13 27 47585 4546 79692230
Cytomegalovirus test positive 37.58 14.13 30 47582 5917 79690859
Dermatitis exfoliative 37.56 14.13 39 47573 10790 79685986
Intentional product misuse 37.36 14.13 6 47606 95159 79601617
Staphylococcal sepsis 37.28 14.13 45 47567 14681 79682095
Infective aneurysm 37.09 14.13 16 47596 992 79695784
Moraxella infection 36.86 14.13 14 47598 623 79696153
Pleural effusion 36.80 14.13 178 47434 145084 79551692
Intentional overdose 36.74 14.13 9 47603 105951 79590825
Aortic dilatation 36.53 14.13 19 47593 1793 79694983
Aplasia 36.21 14.13 33 47579 7787 79688989
Perinephric abscess 35.90 14.13 11 47601 252 79696524
Blood alkaline phosphatase increased 35.75 14.13 101 47511 63563 79633213
Skin mass 35.35 14.13 33 47579 8030 79688746
Hypoaesthesia 35.30 14.13 33 47579 179319 79517457
Staphylococcal infection 35.23 14.13 95 47517 58200 79638576
Oroantral fistula 35.21 14.13 12 47600 389 79696387
Bacterial sepsis 34.88 14.13 33 47579 8165 79688611
Cardiac failure congestive 34.70 14.13 21 47591 142381 79554395
Vascular compression 34.61 14.13 13 47599 561 79696215
Toxoplasmosis 34.55 14.13 21 47591 2676 79694100
Metabolic acidosis 34.37 14.13 118 47494 82411 79614365
Renal artery stenosis 34.37 14.13 23 47589 3459 79693317
Hypoalbuminaemia 33.97 14.13 52 47560 21245 79675531
Inappropriate schedule of product administration 33.56 14.13 19 47593 133609 79563167
Hyperammonaemia 33.29 14.13 37 47575 11056 79685720
Syncope 33.04 14.13 35 47577 179414 79517362
Paraesthesia 32.90 14.13 34 47578 176289 79520487
Graft versus host disease in skin 32.87 14.13 28 47584 6045 79690731
Periostitis 32.85 14.13 13 47599 647 79696129
Febrile infection 32.78 14.13 22 47590 3324 79693452
Emphysematous pyelonephritis 32.78 14.13 11 47601 340 79696436
Hospitalisation 32.68 14.13 8 47604 94228 79602548
Dyspepsia 32.67 14.13 12 47600 108675 79588101
Polyomavirus-associated nephropathy 32.63 14.13 27 47585 5600 79691176
Abscess fungal 32.50 14.13 11 47601 349 79696427
Pseudomonal sepsis 32.47 14.13 28 47584 6146 79690630
Lower respiratory tract infection fungal 32.36 14.13 14 47598 874 79695902
Constipation 32.35 14.13 76 47536 282974 79413802
Neutropenic colitis 32.30 14.13 27 47585 5680 79691096
Respiratory distress 32.22 14.13 92 47520 58247 79638529
Chronic obstructive pulmonary disease 32.18 14.13 6 47606 85413 79611363
Activated partial thromboplastin time prolonged 32.04 14.13 41 47571 14187 79682589
Hypofibrinogenaemia 32.01 14.13 18 47594 1984 79694792
Pulmonary mucormycosis 31.76 14.13 15 47597 1150 79695626
Brain herniation 31.67 14.13 30 47582 7433 79689343
Pneumonia pseudomonal 31.47 14.13 27 47585 5884 79690892
Balance disorder 31.30 14.13 10 47602 98847 79597929
Blood cholesterol increased 31.29 14.13 6 47606 83714 79613062
Respiratory tract infection fungal 31.19 14.13 15 47597 1198 79695578
Sideroblastic anaemia 31.05 14.13 10 47602 271 79696505
Suicide attempt 30.87 14.13 6 47606 82926 79613850
Splenomegaly 30.77 14.13 49 47563 20705 79676071
Cerebral cyst 30.62 14.13 11 47601 418 79696358
Chest pain 30.54 14.13 78 47534 282226 79414550
Pericarditis 30.51 14.13 12 47600 104224 79592552
Immunosuppressant drug level increased 30.40 14.13 32 47580 8995 79687781
Stenotrophomonas infection 30.39 14.13 22 47590 3751 79693025
Pneumonia moraxella 30.27 14.13 8 47604 105 79696671
Injury 30.16 14.13 5 47607 77491 79619285
Ureaplasma infection 30.11 14.13 14 47598 1036 79695740
Vomiting 29.98 14.13 254 47358 665574 79031202
Weight decreased 29.97 14.13 110 47502 355088 79341688
Venoocclusive liver disease 29.85 14.13 36 47576 11735 79685041
Hepatitis cholestatic 29.76 14.13 39 47573 13813 79682963
Bronchial anastomosis complication 29.73 14.13 7 47605 55 79696721
Nasal congestion 29.66 14.13 5 47607 76547 79620229
Hepatic cytolysis 29.65 14.13 56 47556 27095 79669681
Capillary leak syndrome 29.62 14.13 22 47590 3903 79692873
Urinary tract infection 29.57 14.13 76 47536 274436 79422340
Suicidal ideation 29.55 14.13 5 47607 76335 79620441
Neurotoxicity 29.42 14.13 62 47550 32456 79664320
Memory impairment 29.36 14.13 15 47597 111719 79585057
Liver transplant failure 29.35 14.13 8 47604 119 79696657
Scopulariopsis infection 29.35 14.13 8 47604 119 79696657
Varicella zoster virus infection 29.34 14.13 23 47589 4418 79692358
Electrolyte imbalance 29.25 14.13 60 47552 30821 79665955
Acute lymphocytic leukaemia 29.15 14.13 24 47588 4945 79691831
Eye abscess 29.12 14.13 10 47602 332 79696444
Systemic inflammatory response syndrome 28.97 14.13 35 47577 11430 79685346
Splenic infarction 28.69 14.13 21 47591 3643 79693133
Organising pneumonia 28.63 14.13 34 47578 10905 79685871
Adenovirus infection 28.54 14.13 30 47582 8417 79688359
Hyperhidrosis 28.50 14.13 29 47583 151463 79545313
Pyelonephritis fungal 28.44 14.13 9 47603 230 79696546
Hepatotoxicity 28.38 14.13 81 47531 51271 79645505
Fluid retention 28.32 14.13 4 47608 69805 79626971
Device related infection 28.30 14.13 63 47549 34231 79662545
Bacterial pericarditis 28.23 14.13 7 47605 70 79696706
Blood 25-hydroxycholecalciferol decreased 27.86 14.13 10 47602 379 79696397
Torsade de pointes 27.82 14.13 45 47567 19267 79677509
Complications of transplanted kidney 27.80 14.13 26 47586 6340 79690436
Renal tubular disorder 27.39 14.13 26 47586 6460 79690316
Hypersensitivity 27.18 14.13 74 47538 262165 79434611
Pancreatitis acute 27.18 14.13 78 47534 49526 79647250
Neck pain 26.95 14.13 6 47606 75411 79621365
Granulomatous liver disease 26.94 14.13 14 47598 1319 79695457
Pneumothorax 26.79 14.13 55 47557 28268 79668508
Tooth deposit 26.61 14.13 9 47603 285 79696491
Tachypnoea 26.57 14.13 59 47553 32004 79664772
Deep vein thrombosis 26.55 14.13 20 47592 120899 79575877
Renal tubular necrosis 26.55 14.13 51 47561 24988 79671788
Sleep disorder 26.53 14.13 9 47603 85668 79611108
Influenza 26.51 14.13 23 47589 129583 79567193
Respiratory gas exchange disorder 26.45 14.13 12 47600 839 79695937
Bacterial infection 26.42 14.13 58 47554 31222 79665554
Toxicity to various agents 26.30 14.13 146 47466 421394 79275382
Wheezing 26.00 14.13 19 47593 116645 79580131
Bone marrow transplant 25.85 14.13 14 47598 1434 79695342
Agranulocytosis 25.83 14.13 72 47540 44958 79651818
Osteoarthritis 25.64 14.13 10 47602 87299 79609477
Drug level decreased 25.60 14.13 37 47575 14365 79682411
Endocarditis candida 25.38 14.13 7 47605 109 79696667
Palpitations 25.26 14.13 23 47589 126587 79570189
Lung transplant rejection 25.12 14.13 14 47598 1517 79695259
Serratia sepsis 25.08 14.13 8 47604 210 79696566
Thrombotic microangiopathy 25.07 14.13 44 47568 20125 79676651
Disease progression 24.96 14.13 192 47420 184170 79512606
Hyperparathyroidism secondary 24.89 14.13 17 47595 2643 79694133
Acute graft versus host disease in liver 24.61 14.13 15 47597 1920 79694856
Upper respiratory tract infection 24.31 14.13 12 47600 91156 79605620
Vitamin B1 decreased 24.27 14.13 10 47602 553 79696223
Chest discomfort 24.22 14.13 28 47584 138016 79558760
Neurological decompensation 24.00 14.13 22 47590 5231 79691545
Fluorosis 23.93 14.13 7 47605 136 79696640
Benign prostatic hyperplasia 23.88 14.13 32 47580 11580 79685196
Infusion related reaction 23.84 14.13 65 47547 230172 79466604
Retinitis viral 23.74 14.13 7 47605 140 79696636
Idiopathic pneumonia syndrome 23.72 14.13 10 47602 586 79696190
Alanine aminotransferase increased 23.53 14.13 172 47440 162398 79534378
Optic discs blurred 23.51 14.13 6 47606 68 79696708
Intervertebral disc space narrowing 23.49 14.13 14 47598 1721 79695055
Squamous cell carcinoma of skin 23.43 14.13 35 47577 13998 79682778
Mediastinitis 23.18 14.13 11 47601 853 79695923
Influenza like illness 23.15 14.13 7 47605 71700 79625076
CNS ventriculitis 23.11 14.13 9 47603 429 79696347
Cerebral fungal infection 22.93 14.13 9 47603 438 79696338
Death 22.90 14.13 222 47390 566292 79130484
Blood pressure systolic increased 22.63 14.13 6 47606 66980 79629796
Amnesia 22.57 14.13 5 47607 63052 79633724
Injection site reaction 22.55 14.13 3 47609 54782 79641994
Heart rate decreased 22.46 14.13 7 47605 70309 79626467
Hemiparesis 22.45 14.13 57 47555 33676 79663100
Transplant rejection 22.36 14.13 41 47571 19396 79677380
Cough 22.34 14.13 128 47484 366661 79330115
Burning sensation 22.34 14.13 4 47608 58628 79638148
Organic brain syndrome 22.24 14.13 9 47603 475 79696301
Respiratory disorder 22.16 14.13 68 47544 44788 79651988
Granuloma 22.07 14.13 26 47586 8271 79688505
Keratitis fungal 21.97 14.13 8 47604 316 79696460
Acinetobacter infection 21.93 14.13 16 47596 2761 79694015
Sinusitis 21.92 14.13 53 47559 195448 79501328
Blastomycosis 21.91 14.13 10 47602 709 79696067
Cerebrovascular accident 21.76 14.13 37 47575 155255 79541521
Overgrowth fungal 21.60 14.13 6 47606 96 79696680
Drug clearance decreased 21.49 14.13 17 47595 3310 79693466
Vision blurred 21.40 14.13 19 47593 105879 79590897
Intestinal infarction 21.33 14.13 12 47600 1324 79695452
Retinal ischaemia 21.04 14.13 10 47602 778 79695998
Necrosis 20.82 14.13 27 47585 9466 79687310
Graft versus host disease in liver 20.79 14.13 13 47599 1741 79695035
Muscle abscess 20.77 14.13 11 47601 1077 79695699
Mean cell volume increased 20.76 14.13 22 47590 6231 79690545
Human herpesvirus 6 infection reactivation 20.74 14.13 9 47603 566 79696210
Engraftment syndrome 20.74 14.13 12 47600 1397 79695379
Unevaluable event 20.73 14.13 4 47608 55581 79641195
Blast cell count increased 20.73 14.13 12 47600 1398 79695378
Pseudohyperphosphataemia 20.69 14.13 4 47608 10 79696766
Serratia infection 20.64 14.13 13 47599 1763 79695013
Troponin T increased 20.63 14.13 17 47595 3505 79693271
Meningitis 20.62 14.13 27 47585 9555 79687221
Mucosal disorder 20.61 14.13 17 47595 3511 79693265
Candida test positive 20.60 14.13 11 47601 1095 79695681
Coagulation factor VII level decreased 20.60 14.13 7 47605 225 79696551
Cognitive disorder 20.54 14.13 8 47604 69918 79626858
Enterococcal bacteraemia 20.51 14.13 16 47596 3052 79693724
Circulatory collapse 20.41 14.13 59 47553 37609 79659167
Rectal haemorrhage 20.41 14.13 10 47602 76290 79620486
Angioedema 20.28 14.13 10 47602 76025 79620751
Hypertransaminasaemia 20.28 14.13 30 47582 11894 79684882
Speech disorder 20.14 14.13 4 47608 54441 79642335
Acute lymphocytic leukaemia recurrent 20.07 14.13 19 47593 4705 79692071
Cerebral artery embolism 19.90 14.13 13 47599 1878 79694898
Impaired healing 19.89 14.13 14 47598 87641 79609135
Haematochezia 19.89 14.13 14 47598 87631 79609145
Cardiac pacemaker evaluation 19.85 14.13 6 47606 131 79696645
Pulmonary sepsis 19.85 14.13 17 47595 3695 79693081
Drug interaction 19.79 14.13 353 47259 414830 79281946
Hepatocellular injury 19.77 14.13 68 47544 47525 79649251
Bulimia nervosa 19.76 14.13 7 47605 255 79696521
Vesicoureteric reflux 19.64 14.13 6 47606 136 79696640
Dyspnoea exertional 19.64 14.13 14 47598 87059 79609717
Bladder hypertrophy 19.56 14.13 9 47603 650 79696126
Gastrointestinal mucormycosis 19.56 14.13 8 47604 434 79696342
Type 2 diabetes mellitus 19.51 14.13 5 47607 57117 79639659
Urinary tract infection enterococcal 19.50 14.13 16 47596 3279 79693497
Sinusitis fungal 19.48 14.13 14 47598 2360 79694416
Swelling of eyelid 19.47 14.13 17 47595 3794 79692982
Upper airway necrosis 19.27 14.13 3 47609 0 79696776
Carotid artery insufficiency 19.27 14.13 4 47608 16 79696760
Hepatic failure 19.24 14.13 80 47532 61132 79635644
Liver disorder 19.24 14.13 90 47522 72327 79624449
Multiple-drug resistance 19.24 14.13 25 47587 8783 79687993
Transaminases increased 18.99 14.13 71 47541 51672 79645104
Generalised oedema 18.94 14.13 43 47569 23666 79673110
Lung consolidation 18.93 14.13 25 47587 8922 79687854
Productive cough 18.89 14.13 15 47597 88316 79608460
CD4 lymphocytes increased 18.89 14.13 7 47605 291 79696485
Pulpitis dental 18.84 14.13 11 47601 1302 79695474
Lung infiltration 18.80 14.13 42 47570 22870 79673906
Therapeutic product effect incomplete 18.72 14.13 35 47577 141610 79555166
Epileptic encephalopathy 18.67 14.13 8 47604 488 79696288
Drug therapeutic incompatibility 18.58 14.13 6 47606 164 79696612
CARD9 deficiency 18.54 14.13 4 47608 20 79696756
Exophthalmos 18.46 14.13 12 47600 1718 79695058
Herpes simplex 18.38 14.13 29 47583 12158 79684618
Escherichia sepsis 18.35 14.13 24 47588 8484 79688292
Pulmonary interstitial emphysema syndrome 18.26 14.13 8 47604 515 79696261
Oliguria 18.26 14.13 34 47578 16275 79680501
Rash pruritic 18.25 14.13 10 47602 71619 79625157
Renal tubular acidosis 18.22 14.13 16 47596 3598 79693178
Coagulopathy 18.18 14.13 55 47557 35951 79660825
Central nervous system vasculitis 18.13 14.13 11 47601 1397 79695379
Mycobacterial infection 18.01 14.13 16 47596 3652 79693124
Renal abscess 17.95 14.13 10 47602 1083 79695693
ADAMTS13 activity decreased 17.86 14.13 6 47606 186 79696590
Urge incontinence 17.82 14.13 10 47602 1098 79695678
Disseminated aspergillosis 17.74 14.13 10 47602 1108 79695668
Visceral leishmaniasis 17.70 14.13 10 47602 1113 79695663
Blood beta-D-glucan increased 17.61 14.13 8 47604 561 79696215
Klebsiella sepsis 17.61 14.13 15 47597 3237 79693539
Nephrolithiasis 17.57 14.13 5 47607 53286 79643490
Hypoglycaemia 17.40 14.13 21 47591 101573 79595203
International normalised ratio increased 17.36 14.13 15 47597 84706 79612070
Renal injury 17.36 14.13 34 47578 16893 79679883
Abdominal pain 17.31 14.13 149 47463 389420 79307356
Pulmonary mass 17.22 14.13 47 47565 28987 79667789
Orthostatic hypotension 17.22 14.13 6 47606 56158 79640618
Drug reaction with eosinophilia and systemic symptoms 17.18 14.13 80 47532 64164 79632612
Blood urea increased 17.12 14.13 66 47546 48724 79648052
Phaeohyphomycosis 17.10 14.13 10 47602 1187 79695589
Cystitis haemorrhagic 16.94 14.13 24 47588 9148 79687628
Muscular weakness 16.91 14.13 45 47567 160684 79536092
Aspergilloma 16.86 14.13 8 47604 620 79696156
Cataract 16.83 14.13 8 47604 62112 79634664
Inflammatory marker increased 16.81 14.13 26 47586 10714 79686062
Anaemia 16.70 14.13 365 47247 444650 79252126
C-reactive protein increased 16.70 14.13 133 47479 128894 79567882
Diverticulum intestinal 16.62 14.13 23 47589 8582 79688194
Marrow hyperplasia 16.54 14.13 11 47601 1637 79695139
Pneumonia bacterial 16.50 14.13 36 47576 19295 79677481
Cytomegalovirus enterocolitis 16.50 14.13 11 47601 1644 79695132
Pulmonary cavitation 16.49 14.13 11 47601 1645 79695131
Blood glucose increased 16.47 14.13 27 47585 114948 79581828
Pulmonary granuloma 16.25 14.13 12 47600 2109 79694667
Toxic skin eruption 16.24 14.13 39 47573 22254 79674522
BK virus infection 16.21 14.13 23 47589 8781 79687995
Rhinorrhoea 16.17 14.13 13 47599 76061 79620715
Liver abscess 16.15 14.13 19 47593 6035 79690741
Hydrocephalus 16.02 14.13 23 47589 8877 79687899
Aortic arteriosclerosis 15.98 14.13 23 47589 8895 79687881
Pythium insidiosum infection 15.98 14.13 3 47609 6 79696770
Adverse event 15.94 14.13 8 47604 60206 79636570
Cytomegalovirus chorioretinitis 15.94 14.13 18 47594 5472 79691304
Stupor 15.79 14.13 20 47592 6852 79689924
Chorioretinitis 15.69 14.13 9 47603 1031 79695745
Mucocutaneous leishmaniasis 15.66 14.13 7 47605 473 79696303
Musculoskeletal pain 15.65 14.13 23 47589 102331 79594445
Septal panniculitis 15.61 14.13 5 47607 133 79696643
Intracranial mass 15.58 14.13 12 47600 2247 79694529
Graft complication 15.52 14.13 8 47604 741 79696035
Bacteraemia 15.51 14.13 49 47563 32775 79664001
Tumour lysis syndrome 15.46 14.13 40 47572 23899 79672877
Platelet count decreased 15.45 14.13 181 47431 194483 79502293
Leukaemia recurrent 15.44 14.13 13 47599 2761 79694015
Herpes zoster meningoencephalitis 15.40 14.13 8 47604 753 79696023
Implant site infection 15.31 14.13 11 47601 1854 79694922
Dry mouth 15.28 14.13 18 47594 88001 79608775
Renal tubular dysfunction 15.24 14.13 8 47604 769 79696007
Depressed mood 15.17 14.13 5 47607 48475 79648301
Throat irritation 15.16 14.13 3 47609 40943 79655833
Treatment failure 15.11 14.13 162 47450 170324 79526452
Blood potassium increased 15.04 14.13 45 47567 29230 79667546
Hepatitis fulminant 14.92 14.13 20 47592 7242 79689534
Drug level above therapeutic 14.91 14.13 22 47590 8701 79688075
Arteritis coronary 14.90 14.13 4 47608 56 79696720
Aspartate aminotransferase increased 14.83 14.13 137 47475 138504 79558272
Renal disorder 14.81 14.13 57 47555 42048 79654728
Hypoxia 14.80 14.13 109 47503 103134 79593642
Bacterial disease carrier 14.75 14.13 10 47602 1536 79695240
Renal graft infection 14.75 14.13 7 47605 543 79696233
Chondritis 14.73 14.13 5 47607 160 79696616
Blindness unilateral 14.58 14.13 21 47591 8125 79688651
Infective glossitis 14.58 14.13 4 47608 61 79696715
HIV associated nephropathy 14.57 14.13 6 47606 331 79696445
Hypertension 14.52 14.13 127 47485 330865 79365911
Endocarditis 14.33 14.13 24 47588 10573 79686203
Pneumonia necrotising 14.31 14.13 9 47603 1218 79695558
Electrocardiogram T wave biphasic 14.17 14.13 5 47607 180 79696596
Mucosal haemorrhage 14.15 14.13 12 47600 2574 79694202

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hepatotoxicity 66.54 52.08 19 154 98 89521
Drug ineffective 61.12 52.08 32 141 1020 88599

Pharmacologic Action:

SourceCodeDescription
ATC A01AB04 ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS
Antiinfectives and antiseptics for local oral treatment
ATC A07AA07 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFECTIVES
Antibiotics
ATC G01AA03 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Antibiotics
ATC J02AA01 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOTICS FOR SYSTEMIC USE
ANTIMYCOTICS FOR SYSTEMIC USE
Antibiotics
FDA CS M0017172 Polyenes
FDA EPC N0000175498 Polyene Antifungal
FDA EPC N0000175510 Lipid-based Polyene Antifungal
CHEBI has role CHEBI:35820 antiprotozoal drugs
CHEBI has role CHEBI:171664 antiamoebic drugs
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents
MeSH PA D004337 Drug Carriers
MeSH PA D008081 Liposomes
MeSH PA D000563 Amebicides
MeSH PA D000900 Anti-Bacterial Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Trachoma indication 2576002 DOID:11265
Invasive pulmonary aspergillosis indication 3214003
Actinomycotic infection indication 11817007 DOID:8478
Histoplasmosis indication 12962009 DOID:1731
Gonorrhea indication 15628003 DOID:7551
Infection of skin AND/OR subcutaneous tissue indication 19824006
Gingivostomatitis indication 20607006
Candidiasis of the esophagus indication 20639004 DOID:13146
Acute gonococcal cervicitis indication 20943002 DOID:10615
Pulmonary cryptococcosis indication 20953001
Fungal meningitis indication 24321005 DOID:11608
Granuloma inguinale indication 28867007 DOID:9113
Acute gonococcal urethritis indication 29864006
Bronchitis indication 32398004 DOID:6132
Sinusitis indication 36971009
Cryptococcosis indication 42386007 DOID:12053
Gonorrhea of rectum indication 42746002
Candidal meningitis indication 45021001
Candidiasis of skin indication 49883006
Coccidioidomycosis indication 60826002 DOID:13450
Candidal endocarditis indication 63553008
Fungal infection of lung indication 63741006
Aspergillosis indication 65553006 DOID:13564
Urinary tract infectious disease indication 68566005
Blastomycosis indication 69996000 DOID:12663
Disseminated candidiasis indication 70572005
Yaws indication 70647001 DOID:10371
Gonorrhea of pharynx indication 74372003
Rickettsialpox indication 75096007 DOID:11103
Ornithosis indication 75116005 DOID:11262
Brucellosis indication 75702008 DOID:11077
Syphilis indication 76272004
Mucormycosis indication 76627001
Candidiasis indication 78048006 DOID:1508
Candidiasis of mouth indication 79740000 DOID:14262
Leishmaniasis indication 80612004 DOID:9065
Mycotic endocarditis indication 86348002
Acne vulgaris indication 88616000
Disseminated sporotrichosis indication 91051003
Diaper rash indication 91487003
Infectious disease of abdomen indication 128070006
Rocky Mountain spotted fever indication 186772009
Q fever indication 186788009 DOID:11100
Visceral leishmaniasis indication 186803007 DOID:9146
Lymphogranuloma venereum indication 186946009 DOID:13819
Candidal septicemia indication 187022007
Pneumonia indication 233604007 DOID:552
Inclusion conjunctivitis indication 266109000
Infective otitis media indication 312218008
Pharyngitis indication 405737000 DOID:2275
Anthrax indication 409498004 DOID:7427
Relapsing fever indication 420079008 DOID:13034
Chlamydia trachomatis infection of genital structure indication 428015005
Candidemia indication 432261003
Septicemia due to fungus indication 446903007
Fungal Urinary Tract Infection indication
Cryptococcal Septicemia indication
Candida Peritonitis indication
Refractory Aspergillosis indication
Sexually Transmitted Epididymo-Orchitis indication
Cryptococcal Meningitis in HIV indication
Rhinocerebral Phycomycosis indication
Female Urethral Syndrome indication
Rectal Chlamydia Trachomatis Infection indication
Opportunistic Fungal Infection indication
Inflammatory Disease of Female Pelvic Organs indication
Typhus Infections indication
Cryptococcal meningitis off-label use 14232007
Tularemia off-label use 19265001
Pneumonia due to Mycoplasma pneumoniae off-label use 46970008
Tropical sprue off-label use 47384003 DOID:10607
Meningoencephalitis due to Naegleria off-label use 52281009
Plague off-label use 58750007 DOID:3482
Paracoccidioidomycosis off-label use 59925007 DOID:12662
Malaria off-label use 61462000 DOID:12365
Cholangitis off-label use 82403002 DOID:9446
Chlamydial infection off-label use 105629000
Ocular rosacea off-label use 200933006
Selective decontamination of the digestive tract off-label use 235453002
Infection due to Penicillium marneffei off-label use 372936000
Rosacea off-label use 398909004 DOID:8881
Ventilator-acquired pneumonia off-label use 429271009
Helicobacter pylori-associated gastritis off-label use 708164002
Candidal Urinary Tract Infection off-label use
Oropharyngeal Candidiasis off-label use
Chloroquine Resistant Plasmodium Falciparum Malaria off-label use
Hypokalemia contraindication 43339004
Kidney disease contraindication 90708001 DOID:557
Hypomagnesemia contraindication 190855004
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Pseudomembranous enterocolitis contraindication 397683000
Breastfeeding (mother) contraindication 413712001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.46 acidic
pKa2 10.11 acidic
pKa3 12.11 acidic
pKa4 12.74 acidic
pKa5 13.7 acidic
pKa6 8.62 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4017616 VUID
N0000145996 NUI
D00203 KEGG_DRUG
151803 RXNORM
C0002679 UMLSCUI
CHEBI:2682 CHEBI
CHEMBL267345 ChEMBL_ID
D000666 MESH_DESCRIPTOR_UI
DB00681 DRUGBANK_ID
C068538 MESH_SUPPLEMENTAL_RECORD_UI
869 INN_ID
7XU7A7DROE UNII
5280965 PUBCHEM_CID
2715 MMSL
358341 MMSL
3777 MMSL
4190 MMSL
4193 MMSL
5754 MMSL
d00077 MMSL
d04238 MMSL
412088006 SNOMEDCT_US
714520003 SNOMEDCT_US
77703004 SNOMEDCT_US
4017616 VANDF
4021053 VANDF
002887 NDDF
006390 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
AmBisome HUMAN PRESCRIPTION DRUG LABEL 1 0469-3051 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 50 mg INTRAVENOUS NDA 20 sections
AmBisome HUMAN PRESCRIPTION DRUG LABEL 1 0469-3051 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 50 mg INTRAVENOUS NDA 20 sections
Amphotericin B HUMAN PRESCRIPTION DRUG LABEL 1 39822-1055 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 50 mg INTRAVENOUS ANDA 24 sections
Amphotericin B Human Prescription Drug Label 1 55150-365 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 50 mg INTRAVENOUS ANDA 20 sections
ABELCET HUMAN PRESCRIPTION DRUG LABEL 3 57665-101 INJECTION 5 mg INTRAVENOUS NDA 20 sections
ABELCET HUMAN PRESCRIPTION DRUG LABEL 3 57665-101 INJECTION 5 mg INTRAVENOUS NDA 20 sections
Amphotericin B Human Prescription Drug Label 1 62756-233 INJECTABLE, LIPOSOMAL 50 mg INTRAVENOUS ANDA 22 sections