nystatin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antibiotics, polyene derivatives	1977	1400-61-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: nystatin A1 nystatin nystatine	Macrolide antifungal antibiotic complex produced by Streptomyces noursei, S. aureus, and other Streptomyces species. The biologically active components of the complex are nystatin A1, A2, and A3. Molecular weight: 926.11 Formula: C47H75NO17 CLOGP: -3.20 LIPINSKI: 3 HAC: 18 HDO: 12 TPSA: 319.61 ALOGS: -4.03 ROTB: 3 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

nystatin A1
nystatin
nystatine

Macrolide antifungal antibiotic complex produced by Streptomyces noursei, S. aureus, and other Streptomyces species. The biologically active components of the complex are nystatin A1, A2, and A3.

Molecular weight: 926.11
Formula: C47H75NO17
CLOGP: -3.20
LIPINSKI: 3
HAC: 18
HDO: 12
TPSA: 319.61
ALOGS: -4.03
ROTB: 3

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
1.50	MU	O
0.10	MU	V

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	4	Bocci G, Oprea TI, Benet LZ
S (Water solubility)	0.11 mg/mL	Bocci G, Oprea TI, Benet LZ
BA (Bioavailability)	1 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
July 8, 1964	FDA	DELCOR ASSET CORP

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypomania	253.06	10.57	110	42200	6220	63440492
Jaundice cholestatic	243.93	10.57	112	42198	7212	63439500
Schizophrenia	217.02	10.57	114	42196	9838	63436874
Drug ineffective	168.86	10.57	274	42036	1044491	62402221
Candida infection	163.49	10.57	142	42168	28209	63418503
Nasal polyps	154.35	10.57	77	42233	5962	63440750
Blood bilirubin increased	145.20	10.57	150	42160	36990	63409722
Febrile neutropenia	143.89	10.57	272	42038	118177	63328535
Pneumonia	117.44	10.57	607	41703	456160	62990552
Oral candidiasis	117.16	10.57	107	42203	22691	63424021
Contraindicated product administered	117.05	10.57	7	42303	217641	63229071
Psychotic disorder	109.91	10.57	109	42201	25603	63421109
Salpingo-oophorectomy unilateral	104.60	10.57	34	42276	847	63445865
Sputum increased	102.43	10.57	44	42266	2415	63444297
Hepatotoxicity	99.34	10.57	123	42187	36918	63409794
Sinusitis fungal	97.35	10.57	39	42271	1792	63444920
Sepsis	93.15	10.57	268	42042	152855	63293857
Cholelithiasis	91.72	10.57	129	42181	43796	63402916
Maternal exposure during pregnancy	89.02	10.57	19	42291	220043	63226669
Systemic lupus erythematosus	88.79	10.57	16	42294	208902	63237810
Asthma-chronic obstructive pulmonary disease overlap syndrome	86.25	10.57	37	42273	2024	63444688
Rheumatoid arthritis	84.09	10.57	32	42278	253787	63192925
Completed suicide	83.75	10.57	3	42307	145670	63301042
Respiratory symptom	83.54	10.57	42	42268	3305	63443407
Embolism venous	82.92	10.57	41	42269	3113	63443599
Pemphigus	82.71	10.57	12	42298	183714	63262998
Total lung capacity increased	82.20	10.57	37	42273	2273	63444439
Treatment failure	80.88	10.57	17	42293	199026	63247686
Arthropathy	80.49	10.57	28	42282	234764	63211948
Hiatus hernia	76.89	10.57	83	42227	21511	63425201
Fungal infection	76.55	10.57	108	42202	36766	63409946
Drug intolerance	75.81	10.57	57	42253	308604	63138108
Pericarditis	74.65	10.57	3	42307	131576	63315136
Synovitis	73.84	10.57	17	42293	186901	63259811
Diastolic dysfunction	67.22	10.57	46	42264	6425	63440287
Glossodynia	65.43	10.57	19	42291	178857	63267855
Mucosal inflammation	64.81	10.57	114	42196	46814	63399898
Therapeutic product effect decreased	62.90	10.57	25	42285	193162	63253550
Abdominal discomfort	57.40	10.57	78	42232	320807	63125905
Discomfort	57.27	10.57	20	42290	167354	63279358
Joint swelling	57.26	10.57	81	42229	327585	63119127
Wound	56.74	10.57	19	42291	163244	63283468
Infusion related reaction	55.69	10.57	49	42261	245472	63201240
Sarcoidosis	54.34	10.57	42	42268	7080	63439632
Obstructive airways disorder	54.31	10.57	68	42242	20631	63426081
Emphysema	51.68	10.57	49	42261	10889	63435823
Oedema peripheral	49.96	10.57	254	42056	189257	63257455
Helicobacter infection	49.80	10.57	3	42307	92782	63353930
Female genital tract fistula	47.93	10.57	40	42270	7519	63439193
Tricuspid valve incompetence	46.53	10.57	53	42257	14568	63432144
BK virus infection	45.61	10.57	28	42282	3251	63443461
Toxic epidermal necrolysis	45.05	10.57	69	42241	25265	63421447
Toxicity to various agents	44.29	10.57	60	42250	247190	63199522
Venous pressure jugular increased	44.04	10.57	16	42294	561	63446151
Chronic sinusitis	43.34	10.57	48	42262	12795	63433917
Exposure during pregnancy	43.18	10.57	25	42285	155522	63291190
Diverticulum	42.52	10.57	46	42264	11945	63434767
Alopecia	41.66	10.57	103	42207	337433	63109279
Respiratory failure	40.13	10.57	154	42156	101704	63345008
Hysterectomy	40.09	10.57	40	42270	9459	63437253
Cellulitis	39.17	10.57	132	42178	81826	63364886
Wheezing	38.87	10.57	146	42164	95449	63351263
Musculoskeletal stiffness	38.17	10.57	40	42270	184578	63262134
Drug abuse	37.01	10.57	3	42307	72515	63374197
SARS-CoV-2 RNA increased	36.67	10.57	9	42301	76	63446636
Rhinitis allergic	36.46	10.57	42	42268	11685	63435027
Iron deficiency anaemia	36.37	10.57	55	42255	19914	63426798
Autonomic dysreflexia	36.00	10.57	12	42298	324	63446388
Neutropenia	35.74	10.57	219	42091	174786	63271926
Chronic obstructive pulmonary disease	35.46	10.57	107	42203	62579	63384133
Urinary tract infection	35.37	10.57	299	42011	264385	63182327
Thrombocytopenia	35.31	10.57	196	42114	150961	63295751
Tonsillar haemorrhage	34.79	10.57	11	42299	250	63446462
Gastrooesophageal reflux disease	34.76	10.57	141	42169	95498	63351214
Polyomavirus-associated nephropathy	34.22	10.57	19	42291	1829	63444883
Folliculitis	33.04	10.57	4	42306	70313	63376399
Parainfluenzae virus infection	32.70	10.57	20	42290	2307	63444405
Dyspnoea exertional	31.39	10.57	100	42210	60202	63386510
Stevens-Johnson syndrome	31.11	10.57	58	42252	24892	63421820
Oropharyngeal candidiasis	30.87	10.57	15	42295	1096	63445616
Transplant rejection	30.84	10.57	37	42273	10743	63435969
Rectal prolapse	30.33	10.57	18	42292	1965	63444747
Bronchiectasis	30.17	10.57	45	42265	16097	63430615
Muscle injury	30.02	10.57	4	42306	65341	63381371
Disease recurrence	29.89	10.57	61	42249	27969	63418743
Pulmonary embolism	29.75	10.57	155	42155	116529	63330183
Skin infection	29.74	10.57	43	42267	14959	63431753
Vulvovaginal candidiasis	29.32	10.57	21	42289	3154	63443558
Product use issue	29.01	10.57	65	42245	220455	63226257
Off label use	28.86	10.57	299	42011	674163	62772549
General physical health deterioration	28.47	10.57	57	42253	201345	63245367
Cytokine release syndrome	28.34	10.57	41	42269	14273	63432439
Cardiac murmur	27.82	10.57	41	42269	14511	63432201
Cough	27.43	10.57	307	42003	292436	63154276
Sleep apnoea syndrome	27.13	10.57	60	42250	29073	63417639
Dysphagia	27.11	10.57	124	42186	88461	63358251
Sepsis syndrome	27.03	10.57	13	42297	929	63445783
Asthma	26.90	10.57	161	42149	127400	63319312
Septic shock	26.45	10.57	101	42209	66528	63380184
Kyphosis	26.25	10.57	18	42292	2522	63444190
Blood cholesterol increased	26.25	10.57	15	42295	94017	63352695
Failure to thrive	26.20	10.57	28	42282	7170	63439542
Nausea	26.12	10.57	749	41561	853722	62592990
Odynophagia	25.30	10.57	28	42282	7458	63439254
Pseudomonas infection	25.00	10.57	34	42276	11179	63435533
Abscess neck	24.65	10.57	11	42299	662	63446050
Cytomegalovirus infection	24.02	10.57	47	42263	20905	63425807
Impaired healing	23.79	10.57	20	42290	102522	63344190
Acute respiratory failure	23.53	10.57	63	42247	34422	63412290
Vomiting	23.43	10.57	512	41798	559105	62887607
Irritable bowel syndrome	23.21	10.57	13	42297	82399	63364313
Pain	22.82	10.57	352	41958	740276	62706436
Diarrhoea	22.64	10.57	630	41680	714736	62731976
Lip swelling	22.47	10.57	58	42252	31005	63415707
Benign laryngeal neoplasm	21.86	10.57	5	42305	30	63446682
Swelling	21.69	10.57	102	42208	275276	63171436
Herpes simplex oesophagitis	21.40	10.57	7	42303	178	63446534
Lung transplant rejection	21.29	10.57	11	42299	916	63445796
Knee arthroplasty	21.25	10.57	5	42305	54201	63392511
Deep vein thrombosis	21.13	10.57	111	42199	83689	63363023
Fibromyalgia	20.82	10.57	14	42296	80406	63366306
Pulmonary oedema	20.81	10.57	82	42228	54791	63391921
C-reactive protein abnormal	20.75	10.57	3	42307	46093	63400619
Arthralgia	20.64	10.57	262	42048	569448	62877264
Pleural effusion	20.52	10.57	119	42191	93091	63353621
Intentional overdose	20.45	10.57	12	42298	74140	63372572
COVID-19 pneumonia	20.23	10.57	35	42275	14174	63432538
Dehydration	20.12	10.57	190	42120	173164	63273548
Otitis media	19.55	10.57	20	42290	4871	63441841
Oesophagitis	18.85	10.57	35	42275	14973	63431739
Oesophageal candidiasis	18.82	10.57	21	42289	5642	63441070
Atrial fibrillation	18.42	10.57	137	42173	116499	63330213
Mouth ulceration	18.36	10.57	56	42254	32928	63413784
Injection site erythema	18.35	10.57	17	42293	83157	63363555
Herpes simplex	18.32	10.57	25	42285	8246	63438466
Acute kidney injury	18.15	10.57	261	42049	263154	63183558
Culture stool positive	18.05	10.57	7	42303	295	63446417
Lung neoplasm malignant	17.79	10.57	40	42270	19593	63427119
Neuropathy peripheral	17.66	10.57	133	42177	113534	63333178
Neutropenic infection	17.32	10.57	11	42299	1356	63445356
Haematemesis	17.28	10.57	52	42258	30360	63416352
Eczema	17.21	10.57	54	42256	32237	63414475
Tongue ulceration	16.89	10.57	16	42294	3550	63443162
Acute generalised exanthematous pustulosis	16.68	10.57	28	42282	11071	63435641
Bartonellosis	16.60	10.57	4	42306	31	63446681
Clostridium difficile colitis	16.55	10.57	40	42270	20529	63426183
Pancytopenia	16.54	10.57	116	42194	96817	63349895
Peripheral swelling	16.29	10.57	107	42203	265835	63180877
Conjunctivitis	16.27	10.57	40	42270	20756	63425956
Renal artery stenosis	16.20	10.57	12	42298	1897	63444815
Pneumonitis	16.18	10.57	56	42254	35166	63411546
Hydronephrosis	16.16	10.57	27	42283	10635	63436077
Tongue blistering	15.77	10.57	11	42299	1584	63445128
Strongyloidiasis	15.70	10.57	10	42300	1238	63445474
Mental status changes	15.69	10.57	60	42250	39539	63407173
Epiglottic erythema	15.60	10.57	4	42306	41	63446671
Keratitis	15.54	10.57	15	42295	3407	63443305
Blood test abnormal	15.48	10.57	33	42277	15596	63431116
Complications of transplanted kidney	15.44	10.57	13	42297	2473	63444239
Gastrointestinal disorder	15.42	10.57	41	42269	131198	63315514
Onychalgia	15.34	10.57	9	42301	962	63445750
Supraventricular tachycardia	15.15	10.57	31	42279	14240	63432472
Bundle branch block left	15.13	10.57	21	42289	7038	63439674
Liver injury	15.05	10.57	11	42299	60509	63386203
Hypersensitivity	14.94	10.57	124	42186	292561	63154151
Urosepsis	14.88	10.57	36	42274	18488	63428224
Blood culture positive	14.79	10.57	17	42293	4718	63441994
Psoriatic arthropathy	14.62	10.57	24	42286	91496	63355216
Respiratory tract infection viral	14.52	10.57	12	42298	2225	63444487
Osteoporosis	14.49	10.57	76	42234	57262	63389450
Neutropenic sepsis	14.35	10.57	33	42277	16405	63430307
Pharyngotonsillitis	14.23	10.57	5	42305	159	63446553
Injection site pain	14.18	10.57	42	42268	129758	63316954
Hip arthroplasty	14.18	10.57	7	42303	47639	63399073
Type 2 diabetes mellitus	14.16	10.57	13	42297	63855	63382857
Tracheitis	14.14	10.57	8	42302	799	63445913
Device expulsion	14.13	10.57	3	42307	34919	63411793
Suicide attempt	13.98	10.57	12	42298	60906	63385806
Pharyngeal ulceration	13.72	10.57	8	42302	846	63445866
Nocardiosis	13.67	10.57	11	42299	1965	63444747
Overdose	13.48	10.57	36	42274	115042	63331670
Bursitis	13.41	10.57	4	42306	37037	63409675
Heart transplant rejection	13.28	10.57	7	42303	608	63446104
Mucosal toxicity	13.26	10.57	6	42304	373	63446339
Productive cough	12.82	10.57	79	42231	63129	63383583
Coronavirus infection	12.76	10.57	15	42295	4263	63442449
Anaemia	12.72	10.57	270	42040	293160	63153552
Visual impairment	12.71	10.57	23	42287	84423	63362289
Distal intestinal obstruction syndrome	12.70	10.57	6	42304	412	63446300
Transfusion	12.68	10.57	30	42280	15187	63431525
Epiglottic oedema	12.57	10.57	4	42306	93	63446619
Ill-defined disorder	12.55	10.57	22	42288	81733	63364979
Pancreatic failure	12.53	10.57	8	42302	995	63445717
Abortion spontaneous	12.51	10.57	8	42302	47187	63399525
Wrong technique in product usage process	12.33	10.57	14	42296	62326	63384386
Gastrointestinal stoma complication	12.14	10.57	10	42300	1845	63444867
Tumour pain	12.12	10.57	9	42301	1428	63445284
Ureteric obstruction	12.07	10.57	10	42300	1860	63444852
Oral pain	12.06	10.57	44	42266	28350	63418362
Colitis	12.04	10.57	64	42246	48464	63398248
Hypertensive emergency	12.02	10.57	10	42300	1872	63444840
Therapeutic response decreased	11.97	10.57	14	42296	61511	63385201
Fungal skin infection	11.83	10.57	15	42295	4607	63442105
Anorexia nervosa	11.80	10.57	5	42305	265	63446447
Drug reaction with eosinophilia and systemic symptoms	11.64	10.57	4	42306	33832	63412880
Sleep disorder	11.59	10.57	23	42287	81543	63365169
Escherichia infection	11.57	10.57	26	42284	12728	63433984
Intentional product use issue	11.51	10.57	45	42265	127847	63318865
Adverse event	11.48	10.57	17	42293	67542	63379170
Cytomegalovirus test positive	11.45	10.57	12	42298	3006	63443706
Radiation pneumonitis	11.35	10.57	9	42301	1574	63445138
Anaemia of malignant disease	11.30	10.57	6	42304	529	63446183
Cardio-respiratory arrest	11.28	10.57	14	42296	59945	63386767
Vitamin D deficiency	11.16	10.57	27	42283	13865	63432847
Coma	11.12	10.57	16	42294	64348	63382364
C-reactive protein increased	10.82	10.57	30	42280	94677	63352035
Oral mucosal blistering	10.74	10.57	16	42294	5717	63440995
Therapeutic product effect incomplete	10.63	10.57	45	42265	125011	63321701
Viral rash	10.61	10.57	5	42305	341	63446371
Atelectasis	10.61	10.57	35	42275	21448	63425264
Escherichia bacteraemia	10.57	10.57	13	42297	3870	63442842

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Oral candidiasis	82.60	11.43	69	25067	12041	34919754
Candida infection	81.67	11.43	81	25055	17634	34914161
Transplant rejection	75.03	11.43	61	25075	10250	34921545
Febrile neutropenia	71.00	11.43	238	24898	136611	34795184
Pelvic mass	66.36	11.43	18	25118	215	34931580
Trichoglossia	64.63	11.43	19	25117	309	34931486
Sepsis	55.58	11.43	252	24884	166309	34765486
Completed suicide	55.19	11.43	4	25132	98164	34833631
Drug abuse	53.06	11.43	5	25131	99091	34832704
Blood electrolytes abnormal	47.87	11.43	20	25116	948	34930847
Respiratory tract infection bacterial	47.62	11.43	24	25112	1758	34930037
Mucosal inflammation	47.26	11.43	93	25043	38529	34893266
Complications of transplanted kidney	46.18	11.43	33	25103	4576	34927219
Blood urea abnormal	44.39	11.43	18	25118	790	34931005
Drug ineffective	43.73	11.43	175	24961	456576	34475219
Malignant transformation	43.49	11.43	18	25118	833	34930962
Respiratory tract infection viral	42.46	11.43	25	25111	2492	34929303
Granulomatous dermatitis	41.90	11.43	13	25123	256	34931539
Pyelonephritis fungal	41.40	11.43	10	25126	72	34931723
Prostate cancer recurrent	40.47	11.43	18	25118	995	34930800
Neutropenia	39.39	11.43	219	24917	156559	34775236
Pyrexia	39.16	11.43	388	24748	332625	34599170
Mouth ulceration	38.25	11.43	45	25091	11865	34919930
Toxicity to various agents	38.24	11.43	53	25083	200309	34731486
Kidney transplant rejection	37.77	11.43	36	25100	7461	34924334
Aplasia	37.35	11.43	29	25107	4559	34927236
Pneumonia	36.31	11.43	409	24727	362218	34569577
Dermatophytosis	34.79	11.43	11	25125	231	34931564
Chronic papillomatous dermatitis	34.23	11.43	8	25128	49	34931746
Urinary tract infection	32.42	11.43	133	25003	83948	34847847
Fungal skin infection	31.42	11.43	21	25115	2613	34929182
Infection reactivation	30.98	11.43	17	25119	1481	34930314
Klebsiella infection	30.37	11.43	34	25102	8497	34923298
Hydronephrosis	29.81	11.43	37	25099	10309	34921486
Odynophagia	28.74	11.43	27	25109	5494	34926301
Disseminated trichosporonosis	28.67	11.43	7	25129	53	34931742
Urinary tract infection pseudomonal	28.27	11.43	14	25122	987	34930808
Trichophytosis	28.26	11.43	10	25126	300	34931495
Cryptococcosis	28.17	11.43	19	25117	2400	34929395
Fungal infection	28.04	11.43	45	25091	15890	34915905
Thrombocytopenia	27.27	11.43	199	24937	156048	34775747
Stomatitis	26.62	11.43	79	25057	42435	34889360
American trypanosomiasis	26.16	11.43	9	25127	248	34931547
Pericarditis fungal	25.95	11.43	8	25128	154	34931641
Dysphagia	25.90	11.43	101	25035	62280	34869515
Gastritis fungal	25.70	11.43	7	25129	85	34931710
Fungal peritonitis	25.28	11.43	12	25124	771	34931024
Cytomegalovirus infection	25.07	11.43	57	25079	26078	34905717
Aspergillus infection	24.92	11.43	37	25099	12217	34919578
Immunosuppressant drug level increased	24.83	11.43	26	25110	6029	34925766
Serum sickness	23.99	11.43	16	25120	1984	34929811
Cryptococcal meningoencephalitis	22.84	11.43	7	25129	132	34931663
Intentional product misuse	22.64	11.43	3	25133	45608	34886187
Oral pain	22.46	11.43	33	25103	10794	34921001
Cerebral haemorrhage neonatal	21.92	11.43	8	25128	263	34931532
Mucormycosis	21.70	11.43	24	25112	5918	34925877
Pneumonia fungal	21.44	11.43	26	25110	7074	34924721
Transposition of the great vessels	20.90	11.43	9	25127	460	34931335
BK virus infection	20.65	11.43	23	25113	5715	34926080
Cutaneous mucormycosis	20.48	11.43	7	25129	189	34931606
Respiratory failure	19.91	11.43	140	24996	108432	34823363
Septic shock	19.80	11.43	103	25033	71731	34860064
IVth nerve paralysis	19.69	11.43	6	25130	111	34931684
Human ehrlichiosis	19.45	11.43	8	25128	364	34931431
Leukopenia	19.35	11.43	93	25043	62763	34869032
Neutrophilic dermatosis	19.15	11.43	7	25129	231	34931564
Glossodynia	19.11	11.43	18	25118	3675	34928120
Interstitial lung disease	18.60	11.43	12	25124	65270	34866525
Toxic epidermal necrolysis	18.36	11.43	45	25091	21601	34910194
Nocardiosis	18.08	11.43	18	25118	3933	34927862
Facial paresis	18.00	11.43	16	25120	3033	34928762
Hepatic function abnormal	17.65	11.43	5	25131	44358	34887437
Heart transplant	17.59	11.43	10	25126	933	34930862
Rhabdomyolysis	17.50	11.43	14	25122	68149	34863646
Parainfluenzae virus infection	17.00	11.43	15	25121	2815	34928980
Morganella infection	16.85	11.43	8	25128	514	34931281
Hypervolaemia	16.74	11.43	41	25095	19668	34912127
Respiratory tract infection	16.74	11.43	41	25095	19671	34912124
Polyomavirus-associated nephropathy	16.65	11.43	17	25119	3827	34927968
Overdose	16.44	11.43	25	25111	91034	34840761
Disseminated cryptococcosis	16.41	11.43	11	25125	1375	34930420
Liver transplant rejection	16.40	11.43	13	25123	2106	34929689
Pneumonia pseudomonal	16.36	11.43	17	25119	3905	34927890
Haemolytic anaemia	16.30	11.43	28	25108	10451	34921344
Failure to thrive	16.11	11.43	25	25111	8576	34923219
Pharyngeal ulceration	16.05	11.43	7	25129	369	34931426
Pseudomonal bacteraemia	15.97	11.43	11	25125	1438	34930357
Dehydration	15.95	11.43	153	24983	129816	34801979
Jarisch-Herxheimer reaction	15.91	11.43	8	25128	583	34931212
Clostridial infection	15.64	11.43	16	25120	3611	34928184
Meningitis fungal	15.59	11.43	5	25131	110	34931685
Oral viral infection	15.48	11.43	4	25132	39	34931756
Hepatic artery thrombosis	15.27	11.43	6	25130	242	34931553
Pulmonary nocardiosis	15.27	11.43	9	25127	899	34930896
Granuloma	15.22	11.43	15	25121	3236	34928559
Postoperative wound infection	15.11	11.43	18	25118	4808	34926987
Coma	15.04	11.43	7	25129	45671	34886124
Meningitis cryptococcal	14.96	11.43	13	25123	2391	34929404
Enterococcal infection	14.65	11.43	25	25111	9281	34922514
Drug intolerance	14.35	11.43	13	25123	59557	34872238
Blood creatinine increased	14.33	11.43	117	25019	94859	34836936
Documented hypersensitivity to administered product	14.04	11.43	6	25130	301	34931494
Staphylococcal infection	13.55	11.43	53	25083	32707	34899088
Neutrophil morphology abnormal	13.13	11.43	4	25132	74	34931721
Cytomegalovirus viraemia	13.09	11.43	21	25115	7409	34924386
Condition aggravated	12.94	11.43	83	25053	192113	34739682
Right ventricular systolic pressure increased	12.92	11.43	6	25130	367	34931428
Lymphadenopathy	12.55	11.43	47	25089	28416	34903379
Graft versus host disease	12.38	11.43	25	25111	10544	34921251
Therapeutic product effect incomplete	12.21	11.43	11	25125	50530	34881265
Mental status changes	12.19	11.43	57	25079	38026	34893769
Osteomyelitis	12.08	11.43	32	25104	16104	34915691
Stevens-Johnson syndrome	12.01	11.43	35	25101	18604	34913191
Cellulitis	11.97	11.43	72	25064	52879	34878916
Eastern Cooperative Oncology Group performance status worsened	11.94	11.43	8	25128	1000	34930795
Restrictive cardiomyopathy	11.79	11.43	7	25129	708	34931087

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hypomania	228.34	10.38	110	56268	7434	79680576
Jaundice cholestatic	199.93	10.38	115	56263	11169	79676841
Febrile neutropenia	197.39	10.38	476	55902	230523	79457487
Candida infection	196.24	10.38	184	56194	38030	79649980
Schizophrenia	159.77	10.38	112	56266	15328	79672682
Drug ineffective	155.41	10.38	334	56044	1080579	78607431
Oral candidiasis	152.76	10.38	143	56235	29485	79658525
Pneumonia	152.76	10.38	890	55488	659356	79028654
Completed suicide	151.27	10.38	5	56373	245762	79442248
Nasal polyps	130.67	10.38	75	56303	7252	79680758
Sepsis	128.81	10.38	451	55927	268977	79419033
Blood bilirubin increased	105.34	10.38	177	56201	66055	79621955
Sinusitis fungal	94.93	10.38	42	56336	2332	79685678
Salpingo-oophorectomy unilateral	92.43	10.38	31	56347	803	79687207
Mucosal inflammation	89.77	10.38	178	56200	75402	79612608
Sputum increased	87.06	10.38	49	56329	4564	79683446
Toxicity to various agents	85.93	10.38	103	56275	421437	79266573
Drug abuse	85.80	10.38	8	56370	162683	79525327
Contraindicated product administered	82.40	10.38	8	56370	157530	79530480
Fungal infection	82.15	10.38	123	56255	41625	79646385
Total lung capacity increased	80.28	10.38	37	56341	2261	79685749
Transplant rejection	78.26	10.38	82	56296	19355	79668655
Psychotic disorder	75.85	10.38	118	56260	41284	79646726
Cholelithiasis	74.92	10.38	134	56244	52530	79635480
Hepatotoxicity	72.21	10.38	130	56248	51222	79636788
Rheumatoid arthritis	69.75	10.38	30	56348	208440	79479570
Asthma-chronic obstructive pulmonary disease overlap syndrome	68.44	10.38	37	56341	3184	79684826
Neutropenia	67.58	10.38	390	55988	287320	79400690
Drug intolerance	67.14	10.38	53	56325	264066	79423944
Therapeutic product effect decreased	66.31	10.38	17	56361	163846	79524164
Respiratory symptom	64.64	10.38	41	56337	4750	79683260
Embolism venous	64.08	10.38	39	56339	4200	79683810
Complications of transplanted kidney	60.83	10.38	44	56334	6322	79681688
Respiratory tract infection viral	58.84	10.38	37	56341	4222	79683788
Arthropathy	58.43	10.38	26	56352	177085	79510925
Pericarditis	58.08	10.38	4	56374	104232	79583778
Treatment failure	57.88	10.38	24	56354	170462	79517548
Hiatus hernia	56.68	10.38	76	56302	23236	79664774
Synovitis	56.63	10.38	18	56360	150716	79537294
Toxic epidermal necrolysis	56.58	10.38	108	56270	44473	79643537
BK virus infection	56.29	10.38	48	56330	8756	79679254
Urinary tract infection	54.29	10.38	356	56022	274156	79413854
Odynophagia	53.31	10.38	52	56326	11275	79676735
Thrombocytopenia	52.45	10.38	344	56034	264915	79423095
Systemic lupus erythematosus	52.12	10.38	11	56367	121138	79566872
Trichoglossia	51.93	10.38	19	56359	640	79687370
Dysphagia	51.12	10.38	196	56182	121940	79566070
Maternal exposure during pregnancy	50.06	10.38	17	56361	136521	79551489
Female genital tract fistula	49.71	10.38	38	56340	5937	79682073
Intentional overdose	49.06	10.38	8	56370	105952	79582058
Diastolic dysfunction	47.85	10.38	48	56330	10763	79677247
Respiratory failure	47.62	10.38	253	56125	180658	79507352
Mouth ulceration	47.48	10.38	92	56286	38302	79649708
Septic shock	47.30	10.38	192	56186	122609	79565401
Sarcoidosis	46.39	10.38	42	56336	8293	79679717
Cellulitis	45.63	10.38	175	56203	108885	79579125
Parainfluenzae virus infection	44.79	10.38	35	56343	5647	79682363
Respiratory tract infection bacterial	44.53	10.38	24	56354	2053	79685957
Prostate cancer recurrent	44.47	10.38	18	56360	800	79687210
Autonomic dysreflexia	43.19	10.38	15	56363	433	79687577
Polyomavirus-associated nephropathy	42.93	10.38	34	56344	5593	79682417
Neutrophilic dermatosis	42.77	10.38	16	56362	574	79687436
Kidney transplant rejection	42.63	10.38	44	56334	10202	79677808
Joint swelling	42.17	10.38	88	56290	288558	79399452
Exposure during pregnancy	41.86	10.38	10	56368	101122	79586888
Stevens-Johnson syndrome	41.47	10.38	88	56290	39078	79648932
Cytomegalovirus infection	40.82	10.38	92	56286	42552	79645458
Pelvic mass	40.64	10.38	19	56359	1200	79686810
Discomfort	40.55	10.38	19	56359	125598	79562412
Emphysema	39.41	10.38	53	56325	16247	79671763
Infection reactivation	39.03	10.38	24	56354	2633	79685377
Tricuspid valve incompetence	38.66	10.38	58	56320	19654	79668356
Infusion related reaction	38.19	10.38	65	56313	230172	79457838
Hydronephrosis	38.07	10.38	54	56324	17400	79670610
Abdominal discomfort	37.84	10.38	75	56303	250652	79437358
Blood electrolytes abnormal	37.74	10.38	21	56357	1913	79686097
Malignant transformation	37.58	10.38	18	56360	1200	79686810
Pulmonary embolism	37.24	10.38	228	56150	171426	79516584
Pemphigus	37.20	10.38	12	56366	99570	79588440
Granulomatous dermatitis	36.40	10.38	13	56365	408	79687602
Klebsiella infection	36.32	10.38	50	56328	15670	79672340
Blood urea abnormal	36.12	10.38	18	56360	1309	79686701
Hysterectomy	35.69	10.38	32	56346	6240	79681770
Duodenal ulcer perforation	35.59	10.38	3	56375	66208	79621802
Oedema peripheral	35.01	10.38	301	56077	251987	79436023
Aspergillus infection	34.24	10.38	54	56324	19107	79668903
Rhinitis allergic	32.93	10.38	42	56336	12227	79675783
SARS-CoV-2 RNA increased	32.84	10.38	9	56369	114	79687896
Fungal skin infection	32.78	10.38	30	56348	6006	79682004
Chronic papillomatous dermatitis	31.67	10.38	8	56370	72	79687938
Overdose	31.48	10.38	51	56327	184155	79503855
Obstructive airways disorder	31.38	10.38	69	56309	31390	79656620
Mucormycosis	31.04	10.38	34	56344	8435	79679575
Pyelonephritis fungal	30.98	10.38	10	56368	229	79687781
Chronic sinusitis	30.95	10.38	42	56336	12984	79675026
Diverticulum	30.90	10.38	45	56333	14851	79673159
Venous pressure jugular increased	30.18	10.38	16	56362	1324	79686686
Pharyngeal ulceration	29.93	10.38	15	56363	1104	79686906
Wheezing	29.89	10.38	162	56216	116502	79571508
Wound	29.89	10.38	23	56355	116156	79571854
Serum sickness	29.81	10.38	23	56355	3643	79684367
Intentional product misuse	29.79	10.38	15	56363	95150	79592860
Musculoskeletal stiffness	29.39	10.38	49	56329	174959	79513051
Suicide attempt	29.25	10.38	11	56367	82921	79605089
General physical health deterioration	28.77	10.38	99	56279	275139	79412871
Oral pain	28.67	10.38	67	56311	31731	79656279
Off label use	28.44	10.38	461	55917	906754	78781256
Pseudomonas infection	28.21	10.38	52	56326	20851	79667159
Leukopenia	27.99	10.38	159	56219	116354	79571656
Vulvovaginal candidiasis	27.80	10.38	19	56359	2495	79685515
Dermatophytosis	27.67	10.38	11	56367	466	79687544
Cytokine release syndrome	27.31	10.38	71	56307	35927	79652083
Rhabdomyolysis	27.07	10.38	20	56358	103111	79584899
Acute respiratory failure	26.94	10.38	98	56280	59443	79628567
Pneumonitis	26.55	10.38	99	56279	60761	79627249
Trichophytosis	26.19	10.38	10	56368	380	79687630
Immunosuppressant drug level increased	25.98	10.38	32	56346	8995	79679015
Pain	25.71	10.38	347	56031	703455	78984555
Pyrexia	25.58	10.38	644	55734	678065	79009945
Chronic obstructive pulmonary disease	24.92	10.38	123	56255	85296	79602714
Pericarditis fungal	24.91	10.38	8	56370	180	79687830
Nocardiosis	24.74	10.38	25	56353	5654	79682356
Cough	24.65	10.38	380	55998	366409	79321601
Aplasia	24.60	10.38	29	56349	7791	79680219
Dehydration	24.57	10.38	276	56102	247911	79440099
Coma	24.55	10.38	21	56357	100628	79587382
Kyphosis	24.36	10.38	18	56360	2673	79685337
Cryptococcosis	24.31	10.38	20	56358	3473	79684537
Oropharyngeal candidiasis	23.61	10.38	15	56363	1742	79686268
American trypanosomiasis	23.44	10.38	9	56369	347	79687663
Failure to thrive	23.44	10.38	35	56343	11809	79676201
Rectal prolapse	23.00	10.38	16	56362	2162	79685848
Hypervolaemia	22.57	10.38	74	56304	42616	79645394
Alopecia	22.33	10.38	86	56292	231269	79456741
Gastrooesophageal reflux disease	22.30	10.38	138	56240	104108	79583902
Hepatic function abnormal	22.18	10.38	12	56366	73095	79614915
Disseminated trichosporonosis	22.08	10.38	7	56371	151	79687859
Vomiting	21.70	10.38	620	55758	665208	79022802
Fungal peritonitis	21.62	10.38	12	56366	1088	79686922
Benign laryngeal neoplasm	21.57	10.38	5	56373	30	79687980
Tonsillar haemorrhage	21.31	10.38	8	56370	290	79687720
Haemolytic anaemia	21.18	10.38	42	56336	17778	79670232
Iron deficiency anaemia	20.90	10.38	52	56326	25620	79662390
Urinary tract infection pseudomonal	20.86	10.38	14	56364	1784	79686226
Abscess neck	20.67	10.38	12	56366	1185	79686825
Heart transplant rejection	20.56	10.38	13	56365	1497	79686513
Gastritis fungal	20.53	10.38	7	56371	191	79687819
Sepsis syndrome	20.51	10.38	13	56365	1504	79686506
Acanthosis	20.51	10.38	9	56369	490	79687520
Blood creatinine increased	20.45	10.38	183	56195	154874	79533136
Jarisch-Herxheimer reaction	20.35	10.38	11	56367	946	79687064
Interstitial lung disease	20.35	10.38	30	56348	112570	79575440
Granuloma	20.09	10.38	27	56351	8270	79679740
Cutaneous mucormycosis	20.09	10.38	7	56371	204	79687806
Therapeutic product effect incomplete	19.98	10.38	44	56334	141601	79546409
Sleep apnoea syndrome	19.97	10.38	64	56314	36414	79651596
Mental status changes	19.95	10.38	97	56281	66862	79621148
Cardiac murmur	19.66	10.38	38	56340	15786	79672224
Product use issue	19.61	10.38	79	56299	209743	79478267
Oesophageal candidiasis	19.34	10.38	28	56350	9190	79678820
Pneumonia fungal	19.21	10.38	31	56347	11179	79676831
Bronchiectasis	18.91	10.38	46	56332	22340	79665670
Fibromyalgia	18.88	10.38	11	56367	64329	79623681
Cryptococcal meningoencephalitis	18.66	10.38	7	56371	253	79687757
Extravasation blood	18.57	10.38	8	56370	416	79687594
Staphylococcal infection	18.49	10.38	86	56292	58209	79629801
Pleural effusion	18.42	10.38	170	56208	145092	79542918
Medication error	18.42	10.38	13	56365	68629	79619381
Heart transplant	18.32	10.38	12	56366	1469	79686541
Injection site erythema	18.25	10.38	17	56361	78180	79609830
Lung transplant rejection	17.95	10.38	12	56366	1519	79686491
Injection site pain	17.77	10.38	41	56337	129797	79558213
Irritable bowel syndrome	17.76	10.38	11	56367	62230	79625780
Pancytopenia	17.63	10.38	187	56191	165558	79522452
IVth nerve paralysis	17.58	10.38	6	56372	164	79687846
Tongue ulceration	17.43	10.38	18	56360	4175	79683835
Lip swelling	17.39	10.38	66	56312	40845	79647165
Glossodynia	17.28	10.38	29	56349	103308	79584702
Dizziness	17.28	10.38	265	56113	526176	79161834
Gastrointestinal disorder	17.21	10.38	38	56340	122167	79565843
Neutropenic sepsis	17.17	10.38	50	56328	27014	79660996
Skin infection	17.06	10.38	39	56339	18206	79669804
Tracheitis	17.01	10.38	11	56367	1317	79686693
Blood culture positive	16.81	10.38	25	56353	8404	79679606
Human ehrlichiosis	16.49	10.38	8	56370	549	79687461
Blood cholesterol increased	16.44	10.38	21	56357	83699	79604311
Arthralgia	16.42	10.38	295	56083	571508	79116502
Chronic respiratory failure	16.37	10.38	15	56363	3007	79685003
Enterococcal infection	16.36	10.38	35	56343	15625	79672385
Viral skin infection	16.17	10.38	5	56373	99	79687911
Herpes simplex oesophagitis	16.14	10.38	7	56371	370	79687640
Peripheral swelling	16.07	10.38	118	56260	269499	79418511
Oral disorder	16.07	10.38	27	56351	10068	79677942
Dyspnoea exertional	16.02	10.38	111	56267	86962	79601048
Disseminated cryptococcosis	16.00	10.38	12	56366	1822	79686188
Bursitis	15.94	10.38	3	56375	35841	79652169
Psoriatic arthropathy	15.91	10.38	19	56359	77980	79610030
Diarrhoea	15.80	10.38	767	55611	879722	78808288
Colitis	15.65	10.38	97	56281	73210	79614800
Somnolence	15.52	10.38	102	56276	238879	79449131
Tongue blistering	15.41	10.38	11	56367	1548	79686462
Bradycardia	15.37	10.38	47	56331	135510	79552500
Escherichia bacteraemia	15.35	10.38	21	56357	6541	79681469
Epiglottic erythema	15.20	10.38	4	56374	43	79687967
Transfusion	15.09	10.38	41	56337	21289	79666721
Onychalgia	15.01	10.38	9	56369	943	79687067
Red blood cell sedimentation rate increased	14.74	10.38	7	56371	45935	79642075
Oesophageal oedema	14.65	10.38	4	56374	50	79687960
Ill-defined disorder	14.59	10.38	15	56363	65860	79622150
Hypersensitivity	14.58	10.38	117	56261	262122	79425888
Oesophagitis	14.58	10.38	44	56334	24245	79663765
Renal artery stenosis	14.57	10.38	15	56363	3467	79684543
Restrictive cardiomyopathy	14.54	10.38	9	56369	999	79687011
Meningitis cryptococcal	14.49	10.38	15	56363	3491	79684519
Headache	14.44	10.38	352	56026	653420	79034590
Adverse event	14.16	10.38	13	56365	60201	79627809
Respiratory arrest	14.04	10.38	12	56366	57538	79630472
Conjunctivitis	13.97	10.38	45	56333	25670	79662340
Pneumonia pseudomonal	13.95	10.38	19	56359	5892	79682118
Disease recurrence	13.94	10.38	65	56313	44044	79643966
Atrial fibrillation	13.65	10.38	206	56172	197680	79490330
Herpes simplex	13.62	10.38	28	56350	12159	79675851
Blood test abnormal	13.50	10.38	35	56343	17675	79670335
Impaired healing	13.40	10.38	26	56352	87629	79600381
Knee arthroplasty	13.26	10.38	7	56371	43241	79644769
Wrong technique in product usage process	13.04	10.38	20	56358	73855	79614155
Meningitis fungal	13.02	10.38	5	56373	193	79687817
Blood pressure systolic increased	12.95	10.38	17	56361	66969	79621041
Clostridial infection	12.94	10.38	18	56360	5696	79682314
Drug hypersensitivity	12.91	10.38	142	56236	298774	79389236
Graft versus host disease	12.83	10.38	31	56347	14995	79673015
Culture stool positive	12.82	10.38	7	56371	614	79687396
Visual impairment	12.68	10.38	29	56349	92102	79595908
Hypoxia	12.67	10.38	120	56258	103123	79584887
Postoperative wound infection	12.44	10.38	28	56350	12933	79675077
Pseudomonal bacteraemia	12.40	10.38	13	56365	3069	79684941
Pulmonary nocardiosis	12.39	10.38	9	56369	1302	79686708
Asthma	12.36	10.38	148	56230	134947	79553063
Aplastic anaemia	12.26	10.38	34	56344	17871	79670139
Nausea	12.14	10.38	808	55570	956388	78731622
Neutrophil morphology abnormal	12.10	10.38	4	56374	99	79687911
Otitis media	12.02	10.38	18	56360	6088	79681922
Ureteric obstruction	11.91	10.38	12	56366	2704	79685306
Bronchopulmonary dysplasia	11.87	10.38	5	56373	246	79687764
Liver transplant rejection	11.84	10.38	13	56365	3235	79684775
Lethargy	11.79	10.38	98	56280	81194	79606816
Anorexia nervosa	11.78	10.38	5	56373	251	79687759
Deep vein thrombosis	11.74	10.38	134	56244	120785	79567225
Oral mucosal blistering	11.70	10.38	18	56360	6233	79681777
Duodenogastric reflux	11.70	10.38	4	56374	110	79687900
Tumour pain	11.66	10.38	11	56367	2288	79685722
Bacteraemia	11.59	10.38	50	56328	32774	79655236
Small intestinal obstruction	11.59	10.38	44	56334	27228	79660782
Urosepsis	11.47	10.38	43	56335	26452	79661558
Respiratory tract infection	11.39	10.38	66	56312	48623	79639387
Pharyngotonsillitis	11.33	10.38	5	56373	276	79687734
Encephalopathy	11.29	10.38	84	56294	67313	79620697
Escherichia sepsis	11.27	10.38	21	56357	8487	79679523
Morganella infection	11.25	10.38	8	56370	1119	79686891
Fungaemia	11.21	10.38	15	56363	4576	79683434
Neutropenic infection	11.15	10.38	11	56367	2416	79685594
Blood pressure fluctuation	11.08	10.38	19	56359	67126	79620884
Lymphadenopathy	11.08	10.38	70	56308	53177	79634833
Acute generalised exanthematous pustulosis	11.06	10.38	32	56346	17222	79670788
Rhinovirus infection	11.00	10.38	20	56358	7933	79680077
Sleep disorder	10.98	10.38	28	56350	85649	79602361
Mucosal disorder	10.96	10.38	13	56365	3515	79684495
Hypophagia	10.95	10.38	62	56316	45305	79642705
Cheilitis	10.88	10.38	16	56362	5325	79682685
Nasopharyngitis	10.81	10.38	121	56257	253760	79434250
Folliculitis	10.76	10.38	14	56364	55366	79632644
Sciatica	10.76	10.38	5	56373	33217	79654793
Dermatitis diaper	10.71	10.38	5	56373	315	79687695
Oral viral infection	10.68	10.38	4	56374	144	79687866
Cardio-respiratory arrest	10.68	10.38	40	56338	108470	79579540
Hepatic artery thrombosis	10.60	10.38	5	56373	322	79687688
Aphthous ulcer	10.52	10.38	31	56347	16858	79671152
Clostridium difficile colitis	10.51	10.38	48	56330	32235	79655775
Supraventricular tachycardia	10.47	10.38	36	56342	21234	79666776
Epiglottic oedema	10.44	10.38	5	56373	333	79687677
Device related infection	10.44	10.38	50	56328	34244	79653766
Haematemesis	10.44	10.38	68	56310	52196	79635814

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Sepsis neonatal	116.42	68.37	24	39	99	89630

Pharmacologic Action:

Source	Code	Description
ATC	A07AA02	ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS INTESTINAL ANTIINFECTIVES Antibiotics
ATC	D01AA01	DERMATOLOGICALS ANTIFUNGALS FOR DERMATOLOGICAL USE ANTIFUNGALS FOR TOPICAL USE Antibiotics
ATC	G01AA01	GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Antibiotics
ATC	G01AA51	GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Antibiotics
FDA CS	M0017172	Polyenes
FDA EPC	N0000175498	Polyene Antifungal
MeSH PA	D000900	Anti-Bacterial Agents
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000935	Antifungal Agents
MeSH PA	D007476	Ionophores
MeSH PA	D049990	Membrane Transport Modulators

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Mucocutaneous candidiasis	indication	29147005
Candidiasis of skin	indication	49883006
Candidal vulvovaginitis	indication	72605008	DOID:2272
Candidiasis of mouth	indication	79740000	DOID:14262
Gastrointestinal candidiasis	indication	84679006
Diaper rash	off-label use	91487003
Telangiectasia disorder	contraindication	247479008
Adrenal cortical hypofunction	contraindication	386584007	DOID:10493
Atrophoderma	contraindication	399979006

🐶 Veterinary Drug Use

Species	Use	Relation
Turkeys	Control and treatment of crop mycosis	Indication
Turkeys	Mycotic diarrhea (Candida albicans)	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Panolog Ointment	Zoetis Inc.	4
Pharmastatin-20 Type A Medicated Article	Zoetis Inc.	1
Panolog Cream	Zoetis Inc.	4
DERMA-VET Ointment	Med-Pharmex Inc.	4
Animax Ointment	Fougera Pharmaceuticals Inc.	4
Derma 4 Ointment	Zoetis Inc.	4
Derm-Otic Ointment	Zoetis Inc.	4
Derma-Vet Cream	Med-Pharmex Inc.	4
Animax Cream	Fougera Pharmaceuticals Inc.	4

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.46	acidic
pKa2	10.11	acidic
pKa3	11.73	acidic
pKa4	12.54	acidic
pKa5	13.88	acidic
pKa6	13.96	acidic
pKa7	8.62	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4017580	VUID
N0000145961	NUI
D00202	KEGG_DRUG
34786-70-4	SECONDARY_CAS_RN
4017580	VANDF
C0028741	UMLSCUI
CHEBI:7660	CHEBI
CHEMBL450895	ChEMBL_ID
D009761	MESH_DESCRIPTOR_UI
DB00646	DRUGBANK_ID
539	INN_ID
BDF1O1C72E	UNII
6433272	PUBCHEM_CID
7597	RXNORM
2828	MMSL
29922	MMSL
5194	MMSL
d01233	MMSL
002889	NDDF
12096000	SNOMEDCT_US
387048002	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Nystatin	HUMAN PRESCRIPTION DRUG LABEL	1	0093-0983	TABLET, FILM COATED	500000 [USPU]	ORAL	ANDA	16 sections
Nystatin	HUMAN PRESCRIPTION DRUG LABEL	1	0093-0983	TABLET, FILM COATED	500000 [USPU]	ORAL	ANDA	16 sections
Nystatin	HUMAN PRESCRIPTION DRUG LABEL	1	0093-0983	TABLET, FILM COATED	500000 [USPU]	ORAL	ANDA	16 sections
Nystatin	HUMAN PRESCRIPTION DRUG LABEL	1	0121-0810	SUSPENSION	100000 [USPU]	ORAL	ANDA	19 sections
Nystatin	HUMAN PRESCRIPTION DRUG LABEL	1	0121-0868	SUSPENSION	100000 [USPU]	ORAL	ANDA	19 sections
Nystatin	HUMAN PRESCRIPTION DRUG LABEL	1	0121-0868	SUSPENSION	100000 [USPU]	ORAL	ANDA	19 sections
Nystatin	HUMAN PRESCRIPTION DRUG LABEL	1	0121-0868	SUSPENSION	100000 [USPU]	ORAL	ANDA	19 sections
Nystatin	HUMAN PRESCRIPTION DRUG LABEL	1	0121-4785	SUSPENSION	100000 [USPU]	ORAL	ANDA	19 sections
Nystatin	HUMAN PRESCRIPTION DRUG LABEL	1	0121-4810	SUSPENSION	100000 [USPU]	ORAL	ANDA	19 sections
Nystatin	HUMAN PRESCRIPTION DRUG LABEL	1	0168-0007	OINTMENT	100000 [USPU]	TOPICAL	ANDA	9 sections
nystatin	HUMAN PRESCRIPTION DRUG LABEL	1	0168-0037	SUSPENSION	100000 [USPU]	ORAL	ANDA	17 sections
nystatin	HUMAN PRESCRIPTION DRUG LABEL	1	0168-0054	CREAM	100000 [USPU]	TOPICAL	ANDA	20 sections
Nystatin and Triamcinolone Acetonide	HUMAN PRESCRIPTION DRUG LABEL	2	0168-0081	CREAM	100000 [USPU]	TOPICAL	ANDA	16 sections
Nystatin and Triamcinolone Acetonide	HUMAN PRESCRIPTION DRUG LABEL	2	0168-0089	OINTMENT	100000 [USPU]	TOPICAL	ANDA	19 sections
Nystatin Cream	HUMAN PRESCRIPTION DRUG LABEL	1	0316-0221	CREAM	100000 [USPU]	TOPICAL	ANDA	18 sections
Nystatin Cream	HUMAN PRESCRIPTION DRUG LABEL	1	0316-0221	CREAM	100000 [USPU]	TOPICAL	ANDA	18 sections
Nystatin and Triamcinolone Acetonide	HUMAN PRESCRIPTION DRUG LABEL	2	0316-0223	CREAM	100000 [USPU]	TOPICAL	ANDA	18 sections
Nystatin and Triamcinolone Acetonide	HUMAN PRESCRIPTION DRUG LABEL	2	0316-0223	CREAM	100000 [USPU]	TOPICAL	ANDA	18 sections
Nystatin and Triamcinolone Acetonide	HUMAN PRESCRIPTION DRUG LABEL	2	0472-0150	CREAM	100000 [USPU]	TOPICAL	ANDA	11 sections
Nystatin and Triamcinolone Acetonide	HUMAN PRESCRIPTION DRUG LABEL	2	0472-0150	CREAM	100000 [USPU]	TOPICAL	ANDA	11 sections
Nystatin and Triamcinolone Acetonide	HUMAN PRESCRIPTION DRUG LABEL	2	0472-0155	OINTMENT	100000 [USPU]	TOPICAL	ANDA	11 sections
Nystatin and Triamcinolone Acetonide	HUMAN PRESCRIPTION DRUG LABEL	2	0472-0155	OINTMENT	100000 [USPU]	TOPICAL	ANDA	11 sections
Nystatin	HUMAN PRESCRIPTION DRUG LABEL	1	0472-0166	OINTMENT	100000 [USPU]	TOPICAL	ANDA	9 sections
Nystatin Oral Suspension	HUMAN PRESCRIPTION DRUG LABEL	1	0527-5121	SOLUTION	100000 [USPU]	ORAL	ANDA	17 sections
Nystop	HUMAN PRESCRIPTION DRUG LABEL	1	0574-2008	POWDER	100000 [USPU]	TOPICAL	ANDA	21 sections
Nystatin	HUMAN PRESCRIPTION DRUG LABEL	1	0713-0678	CREAM	100000 [USPU]	TOPICAL	ANDA	18 sections
Nystatin	HUMAN PRESCRIPTION DRUG LABEL	1	0713-0678	CREAM	100000 [USPU]	TOPICAL	ANDA	18 sections
Nystatin	HUMAN PRESCRIPTION DRUG LABEL	1	0713-0686	OINTMENT	100000 [USPU]	TOPICAL	ANDA	13 sections
Nyamyc	HUMAN PRESCRIPTION DRUG LABEL	1	0832-0465	POWDER	100000 [USPU]	TOPICAL	ANDA	22 sections
Nyamyc	HUMAN PRESCRIPTION DRUG LABEL	1	0832-0465	POWDER	100000 [USPU]	TOPICAL	ANDA	22 sections