novobiocin ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 1974 303-81-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • novobiocin
  • albamycin
  • cardelmycin
  • cathomycin
  • inamycin
  • streptonivicin
  • novobiocin calcium
  • novobiocin sodium
  • novobiocin sodium salt
An antibiotic compound derived from Streptomyces niveus. It has a chemical structure similar to coumarin. Novobiocin binds to DNA gyrase, and blocks adenosine triphosphatase (ATPase) activity. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p189)
  • Molecular weight: 612.63
  • Formula: C31H36N2O11
  • CLOGP: 3.98
  • LIPINSKI: 2
  • HAC: 13
  • HDO: 5
  • TPSA: 196.10
  • ALOGS: -4.80
  • ROTB: 9

Drug dosage:

None

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 40.81 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 0 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Sept. 4, 1964 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D019384 Nucleic Acid Synthesis Inhibitors
CHEBI has role CHEBI:33281 antibiotics
CHEBI has role CHEBI:33282 bactericides
CHEBI has role CHEBI:50750 inhibitors of type II topoisomerase
CHEBI has role CHEBI:62868 hepatoprotective agents
CHEBI has role CHEBI:76971 Escherichia coli metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

None




๐Ÿถ Veterinary Drug Use

SpeciesUseRelation
Cattle Mastitis caused by Staphylococcus aureus Indication
Cattle Mastitis caused by Streptococcus agalactiae Indication
Chickens Treatment of staphylococcal synovitis Indication
Chickens Generalized staphylococcal infections Indication
Chickens Breast blisters associated with staphylococcal infections Indication
Ducks Infectious serositis Indication
Ducks Cholera caused by Pasteurella anatipestifer Indication
Ducks Cholera caused by Pasteurella multocida Indication
Mustelids Generalized infections caused by staphylococcal organisms Indication
Mustelids Abscesses caused by staphylococcal organisms Indication
Mustelids Urinary infections caused by staphylococcal organisms Indication
Turkeys Breast blisters associated with staphylococcal infections Indication
Turkeys Treatment of staphylococcal synovitis Indication
Turkeys Generalized staphylococcal infections Indication
Turkeys Cholera caused by Pasteurella multocida Indication

๐Ÿถ Veterinary products

ProductApplicantIngredients
Albamix Feed Medication Zoetis Inc. 1
Albacillin Suspension, Special Formula 17900-Forte Suspension Zoetis Inc. 2
Albaplex 3x Tablets, Albaplex Tablets Zoetis Inc. 2
Albadry Plus Suspension Zoetis Inc. 2
Delta Albaplex 3x Tablets, Delta Albaplex Tablets Zoetis Inc. 3
Albaplex Capsules Zoetis Inc. 2
Albamast Suspension Zoetis Inc. 1
Biodry Suspension, Drygard Suspension Zoetis Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.33 acidic
pKa2 8.95 acidic
pKa3 10.13 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
ATP-binding cassette sub-family G member 2 Transporter IC50 4.18 CHEMBL
DNA gyrase Enzyme INHIBITOR CHEMBL CHEMBL
DNA gyrase subunit B Enzyme IC50 6.81 CHEMBL
DNA gyrase subunit B Enzyme IC50 7.43 CHEMBL
ParE Enzyme IC50 5.69 CHEMBL
DNA gyrase subunit B Enzyme Kd 7.55 CHEMBL
DNA gyrase Enzyme IC50 7 CHEMBL
DNA gyrase subunit B Enzyme IC50 6.70 CHEMBL
DNA gyrase subunit B Enzyme IC50 6.90 CHEMBL
DNA gyrase subunit B Enzyme IC50 7.34 CHEMBL
DNA gyrase subunit B Enzyme Ki 8.15 CHEMBL
Genome polyprotein Unclassified IC50 4.85 CHEMBL
DNA topoisomerase 4 subunit B Unclassified IC50 5.10 CHEMBL

External reference:

IDSource
4019861 VUID
N0000147947 NUI
D01209 KEGG_DRUG
4309-70-0 SECONDARY_CAS_RN
1476-53-5 SECONDARY_CAS_RN
4018076 VANDF
4019861 VANDF
C0028458 UMLSCUI
CHEBI:28368 CHEBI
NOV PDB_CHEM_ID
CHEMBL36506 ChEMBL_ID
CHEMBL3183453 ChEMBL_ID
D009675 MESH_DESCRIPTOR_UI
DB01051 DRUGBANK_ID
12021 IUPHAR_LIGAND_ID
575 INN_ID
17EC19951N UNII
54675769 PUBCHEM_CID
215076 RXNORM
1436 MMSL
5193 MMSL
d01116 MMSL
002761 NDDF
002762 NDDF
002763 NDDF
371187001 SNOMEDCT_US
65403003 SNOMEDCT_US
90220005 SNOMEDCT_US
CHEMBL3544972 ChEMBL_ID

Pharmaceutical products:

None