nortriptyline ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antidepressants, dibenzo[a,d]cycloheptane or cyclopheptene derivatives 1971 72-69-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nortryptyline
  • nortriptyline
  • demethylamitriptylin
  • desitriptilina
  • desmethylamitriptyline
  • noramitriptyline
  • nortriptyline hydrochloride
  • nortriptyline HCl
A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
  • Molecular weight: 263.38
  • Formula: C19H21N
  • CLOGP: 4.32
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 12.03
  • ALOGS: -5.48
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
75 mg O
30 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 6.34 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 51 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 22 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.12 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 30 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 6, 1964 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Temperature regulation disorder 511.43 13.70 168 30943 5964 63451947
Food allergy 416.64 13.70 170 30941 11231 63446680
Coeliac disease 394.38 13.70 169 30942 12628 63445283
Immunodeficiency 346.22 13.70 178 30933 20076 63437835
Pneumonia aspiration 328.82 13.70 207 30904 34333 63423578
Completed suicide 321.62 13.70 376 30735 145297 63312614
Bursitis 249.24 13.70 179 30932 36862 63421049
Rash erythematous 227.25 13.70 179 30932 42331 63415580
Coma 212.62 13.70 206 30905 64158 63393753
Fluid retention 189.59 13.70 187 30924 59499 63398412
Gastrooesophageal reflux disease 170.66 13.70 222 30889 95417 63362494
Toxicity to various agents 167.49 13.70 372 30739 246878 63211033
Drug hypersensitivity 163.72 13.70 424 30687 310263 63147648
Asthma 162.41 13.70 252 30859 127309 63330602
Upper respiratory tract infection 159.88 13.70 199 30912 81848 63376063
Presbyacusis 151.87 13.70 56 31055 2809 63455102
Hyperhidrosis 148.52 13.70 221 30890 107615 63350296
Pleural fibrosis 144.91 13.70 57 31054 3415 63454496
Pleural thickening 144.20 13.70 54 31057 2829 63455082
Blood magnesium increased 137.87 13.70 53 31058 2985 63454926
Osteopenia 136.22 13.70 97 31014 19688 63438223
Deafness neurosensory 136.09 13.70 60 31051 4795 63453116
Somnolence 135.99 13.70 282 30829 178403 63279508
Neovascularisation 114.39 13.70 36 31075 1109 63456802
Brugada syndrome 111.99 13.70 28 31083 360 63457551
Back pain 110.83 13.70 332 30779 263813 63194098
Epigastric discomfort 102.73 13.70 55 31056 6725 63451186
Overdose 99.92 13.70 192 30919 114886 63343025
Rubber sensitivity 96.34 13.70 38 31073 2293 63455618
Bone cyst 90.55 13.70 36 31075 2218 63455693
Constipation 85.25 13.70 273 30838 224670 63233241
Electrocardiogram QRS complex prolonged 83.93 13.70 46 31065 5892 63452019
Sensitivity to weather change 78.04 13.70 47 31064 7190 63450721
Erythema 77.51 13.70 225 30886 175526 63282385
Paradoxical drug reaction 75.29 13.70 38 31073 4114 63453797
Cyst 74.49 13.70 59 31052 14040 63443871
Rheumatoid arthritis 70.36 13.70 278 30833 253541 63204370
Glossodynia 68.44 13.70 5 31106 178871 63279040
Migraine 68.09 13.70 154 30957 103192 63354719
Forced expiratory volume decreased 66.14 13.70 37 31074 4931 63452980
Osteosclerosis 65.90 13.70 34 31077 3854 63454057
Poor venous access 65.81 13.70 56 31055 14729 63443182
Drug ineffective for unapproved indication 62.13 13.70 80 31031 33983 63423928
Blood potassium increased 59.26 13.70 58 31053 18251 63439660
Systemic lupus erythematosus 56.80 13.70 16 31095 208902 63249009
Somatic delusion 52.50 13.70 17 31094 575 63457336
Traumatic coma 52.20 13.70 11 31100 61 63457850
Hepatic enzyme increased 51.56 13.70 216 30895 202112 63255799
Wound 51.42 13.70 9 31102 163254 63294657
Swelling 50.22 13.70 37 31074 275341 63182570
Pericarditis 49.42 13.70 4 31107 131575 63326336
Hypersensitivity 49.04 13.70 277 30834 292408 63165503
Skin lesion 48.13 13.70 67 31044 30654 63427257
Headache 46.09 13.70 493 30618 632748 62825163
Neutropenia 41.32 13.70 17 31094 174988 63282923
Dry eye 40.34 13.70 72 31039 40689 63417222
Cardiac arrest 40.28 13.70 118 30993 92427 63365484
Suspected suicide 40.20 13.70 30 31081 6538 63451373
Lower respiratory tract infection 40.15 13.70 8 31103 132299 63325612
Mastoiditis 39.44 13.70 16 31095 1039 63456872
Unresponsive to stimuli 39.09 13.70 64 31047 33752 63424159
Maternal exposure during pregnancy 38.29 13.70 31 31080 220031 63237880
Vascular malformation 38.18 13.70 12 31099 368 63457543
Foetal death 37.82 13.70 36 31075 10944 63446967
Paranasal cyst 37.37 13.70 12 31099 395 63457516
Extrapyramidal disorder 37.35 13.70 39 31072 13245 63444666
Unmasking of previously unidentified disease 37.17 13.70 15 31096 961 63456950
Alopecia 37.11 13.70 68 31043 337468 63120443
Polymyositis 37.02 13.70 18 31093 1798 63456113
Deformity 35.93 13.70 36 31075 11648 63446263
Prescribed overdose 34.66 13.70 61 31050 34092 63423819
Bone density abnormal 33.90 13.70 21 31090 3377 63454534
Anuria 33.78 13.70 36 31075 12515 63445396
Pancytopenia 33.63 13.70 4 31107 96929 63360982
Anaemia 33.25 13.70 58 31053 293372 63164539
Alanine aminotransferase abnormal 33.12 13.70 23 31088 4481 63453430
Fatigue 32.03 13.70 611 30500 887417 62570494
Spinal stenosis 31.95 13.70 38 31073 14887 63443024
Osteoarthritis 31.84 13.70 111 31000 95232 63362679
Sleep disorder 31.73 13.70 100 31011 81466 63376445
Febrile neutropenia 30.49 13.70 10 31101 118439 63339472
Occult blood 29.89 13.70 14 31097 1287 63456624
Hypoventilation 29.73 13.70 22 31089 4732 63453179
Femoral neck fracture 29.46 13.70 28 31083 8495 63449416
Abdominal discomfort 28.34 13.70 73 31038 320812 63137099
Helicobacter infection 27.34 13.70 6 31105 92779 63365132
Systolic dysfunction 27.15 13.70 14 31097 1585 63456326
Blister 26.98 13.70 15 31096 129799 63328112
Vomiting 26.63 13.70 163 30948 559454 62898457
Suicidal ideation 25.64 13.70 78 31033 62343 63395568
Acute kidney injury 25.57 13.70 57 31054 263358 63194553
Exostosis 25.10 13.70 37 31074 17825 63440086
Blood pressure abnormal 25.09 13.70 34 31077 15164 63442747
Treatment failure 24.93 13.70 175 30936 198868 63259043
Ventricular tachyarrhythmia 24.92 13.70 7 31104 144 63457767
Leukopenia 24.90 13.70 4 31107 77286 63380625
Stomatitis 24.80 13.70 19 31092 138706 63319205
Accidental death 24.37 13.70 14 31097 1962 63455949
Disease progression 24.35 13.70 15 31096 122743 63335168
Electrocardiogram ST segment elevation 24.17 13.70 18 31093 3909 63454002
Electrocardiogram repolarisation abnormality 23.72 13.70 12 31099 1305 63456606
Carpal tunnel syndrome 23.52 13.70 39 31072 20778 63437133
Immune thrombocytopenia 22.80 13.70 27 31084 10529 63447382
Failed induction of labour 22.69 13.70 8 31103 352 63457559
Ill-defined disorder 22.69 13.70 6 31105 81749 63376162
Malignant neoplasm progression 21.02 13.70 7 31104 82114 63375797
Psoriasis 20.70 13.70 91 31020 86866 63371045
Pleural rub 20.16 13.70 5 31106 62 63457849
Gastrointestinal motility disorder 19.99 13.70 18 31093 5101 63452810
Impaired healing 19.69 13.70 13 31098 102529 63355382
Respiratory arrest 19.67 13.70 47 31064 32598 63425313
Heart rate increased 19.03 13.70 94 31017 94144 63363767
Oral discomfort 18.99 13.70 23 31088 9178 63448733
Abnormal faeces 18.94 13.70 18 31093 5462 63452449
Hyperaesthesia 18.68 13.70 23 31088 9335 63448576
Postmortem blood drug level increased 18.67 13.70 8 31103 596 63457315
Neuropathy peripheral 17.95 13.70 106 31005 113561 63344350
Long QT syndrome 17.92 13.70 14 31097 3265 63454646
Bone hypertrophy 17.83 13.70 7 31104 417 63457494
Antidepressant drug level above therapeutic 17.62 13.70 7 31104 430 63457481
Renal failure 17.59 13.70 19 31092 117633 63340278
Sepsis 17.56 13.70 30 31081 153093 63304818
Cardiac failure 17.53 13.70 11 31100 89131 63368780
Adverse reaction 17.11 13.70 23 31088 10180 63447731
Underdose 17.05 13.70 40 31071 27416 63430495
Essential tremor 16.97 13.70 9 31102 1079 63456832
General physical health deterioration 16.87 13.70 47 31064 201355 63256556
Urine odour abnormal 16.62 13.70 18 31093 6371 63451540
Decreased appetite 16.61 13.70 65 31046 250987 63206924
Asthenia 16.55 13.70 115 30996 383489 63074422
Iodine allergy 16.48 13.70 8 31103 796 63457115
Allodynia 16.34 13.70 8 31103 811 63457100
Intentional product misuse 16.24 13.70 66 31045 60851 63397060
Pain 16.24 13.70 476 30635 740152 62717759
Threatened labour 16.02 13.70 8 31103 846 63457065
Alanine aminotransferase increased 15.24 13.70 17 31094 103753 63354158
Blood pressure increased 15.05 13.70 133 30978 161929 63295982
Hyperkalaemia 15.00 13.70 4 31107 54199 63403712
Serotonin syndrome 14.87 13.70 39 31072 28643 63429268
Noninfectious myelitis 14.85 13.70 3 31108 13 63457898
Pneumonia 14.70 13.70 148 30963 456619 63001292
Delirium 14.47 13.70 56 31055 50485 63407426
Dyspnoea 14.33 13.70 233 30878 661080 62796831
Acute lung injury 13.90 13.70 9 31102 1562 63456349
Type 2 diabetes mellitus 13.82 13.70 7 31104 63861 63394050

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 326.43 18.08 323 8639 200039 34747930
Sedation 271.11 18.08 124 8838 20882 34927087
Completed suicide 164.00 18.08 161 8801 98007 34849962
Nightmare 160.94 18.08 77 8885 14314 34933655
Nephrolithiasis 124.00 18.08 84 8878 30249 34917720
Product used for unknown indication 94.84 18.08 26 8936 957 34947012
Reversible airways obstruction 91.84 18.08 22 8940 467 34947502
Myokymia 88.35 18.08 16 8946 76 34947893
Suicidal ideation 84.09 18.08 75 8887 40313 34907656
Hyperhidrosis 80.46 18.08 98 8864 75594 34872375
Drug abuse 72.63 18.08 107 8855 98989 34848980
Drug ineffective 47.29 18.08 236 8726 456515 34491454
Overdose 44.56 18.08 82 8880 90977 34856992
Serotonin syndrome 43.41 18.08 38 8924 19895 34928074
Feelings of worthlessness 43.01 18.08 11 8951 308 34947661
Electrocardiogram QRS complex prolonged 42.29 18.08 22 8940 4872 34943097
Nausea 41.95 18.08 185 8777 339723 34608246
Brugada syndrome 37.03 18.08 12 8950 789 34947180
Abulia 36.13 18.08 11 8951 589 34947380
Cardio-respiratory arrest 35.22 18.08 56 8906 55217 34892752
Obsessive-compulsive disorder 34.26 18.08 20 8942 5544 34942425
Impaired quality of life 33.43 18.08 20 8942 5798 34942171
Decreased interest 30.60 18.08 14 8948 2346 34945623
Poisoning 30.07 18.08 25 8937 12201 34935768
Suicide attempt 29.69 18.08 43 8919 39073 34908896
Drug hypersensitivity 28.03 18.08 63 8899 80466 34867503
Vertigo 25.36 18.08 32 8930 25504 34922465
Depression 25.33 18.08 68 8894 97030 34850939
Antidepressant discontinuation syndrome 24.37 18.08 4 8958 9 34947960
Anaemia 24.18 18.08 15 8947 233320 34714649
Binocular eye movement disorder 23.03 18.08 5 8957 67 34947902
Fall 22.37 18.08 107 8855 202778 34745191
Respiratory depression 22.22 18.08 24 8938 16221 34931748
Pyrexia 22.13 18.08 32 8930 332981 34614988
Emotional distress 21.97 18.08 23 8939 15003 34932966
Thrombocytopenia 20.91 18.08 7 8955 156240 34791729
Cerebral hypoperfusion 20.81 18.08 7 8955 517 34947452
Drug dependence 20.41 18.08 28 8934 24189 34923780
Restless legs syndrome 20.37 18.08 17 8945 8337 34939632
Product use in unapproved indication 20.09 18.08 71 8891 117428 34830541
Substance abuse 19.57 18.08 16 8946 7625 34940344
Major depression 19.46 18.08 13 8949 4559 34943410
Suspected suicide 19.01 18.08 13 8949 4735 34943234
Depressed level of consciousness 18.96 18.08 37 8925 42804 34905165
Benzodiazepine drug level therapeutic 18.83 18.08 4 8958 48 34947921
Febrile neutropenia 18.54 18.08 6 8956 136843 34811126
Phonophobia 18.26 18.08 5 8957 183 34947786

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Temperature regulation disorder 507.68 13.35 161 34940 5692 79703595
Completed suicide 471.83 13.35 560 34541 245207 79464080
Food allergy 417.93 13.35 163 34938 10661 79698626
Toxicity to various agents 414.77 13.35 697 34404 420843 79288444
Coeliac disease 399.97 13.35 160 34941 11191 79698096
Immunodeficiency 331.75 13.35 171 34930 21597 79687690
Bursitis 255.02 13.35 172 34929 35672 79673615
Pneumonia aspiration 214.76 13.35 201 34900 66766 79642521
Drug hypersensitivity 196.76 13.35 417 34684 298499 79410788
Hyperhidrosis 189.09 13.35 280 34821 151212 79558075
Rash erythematous 186.38 13.35 174 34927 57595 79651692
Fluid retention 165.72 13.35 178 34923 69631 79639656
Coma 147.62 13.35 201 34900 100448 79608839
Upper respiratory tract infection 147.45 13.35 191 34910 90977 79618310
Presbyacusis 146.47 13.35 52 35049 2608 79706679
Asthma 146.47 13.35 234 34867 134861 79574426
Gastrooesophageal reflux disease 142.14 13.35 201 34900 104045 79605242
Brugada syndrome 132.41 13.35 40 35061 1198 79708089
Overdose 131.59 13.35 266 34835 183940 79525347
Pleural thickening 129.72 13.35 49 35052 2933 79706354
Pleural fibrosis 123.79 13.35 52 35049 4115 79705172
Osteopenia 123.16 13.35 85 35016 18279 79691008
Blood magnesium increased 118.57 13.35 48 35053 3458 79705829
Somnolence 116.99 13.35 297 34804 238684 79470603
Sedation 115.60 13.35 128 34973 51767 79657520
Neovascularisation 115.23 13.35 36 35065 1209 79708078
Electrocardiogram QRS complex prolonged 112.25 13.35 66 35035 10767 79698520
Rubber sensitivity 110.96 13.35 38 35063 1711 79707576
Deafness neurosensory 110.30 13.35 56 35045 6842 79702445
Back pain 103.95 13.35 332 34769 303848 79405439
Rheumatoid arthritis 101.91 13.35 259 34842 208211 79501076
Epigastric discomfort 84.16 13.35 49 35052 7847 79701440
Bone cyst 79.67 13.35 36 35065 3397 79705890
Migraine 78.06 13.35 139 34962 87354 79621933
Sensitivity to weather change 75.51 13.35 46 35055 8001 79701286
Myokymia 74.82 13.35 16 35085 109 79709178
Nightmare 72.24 13.35 72 35029 25789 79683498
Constipation 70.86 13.35 279 34822 282771 79426516
Osteosclerosis 68.67 13.35 34 35067 3937 79705350
Hepatic enzyme increased 68.48 13.35 206 34895 182404 79526883
Cyst 67.78 13.35 53 35048 13787 79695500
Hypersensitivity 67.67 13.35 261 34840 261978 79447309
Anaemia 66.35 13.35 59 35042 444956 79264331
Product used for unknown indication 65.82 13.35 25 35076 1519 79707768
Drug ineffective for unapproved indication 64.24 13.35 95 35006 51143 79658144
Febrile neutropenia 62.05 13.35 13 35088 230986 79478301
Poor venous access 61.07 13.35 56 35045 18093 79691194
Neutropenia 58.05 13.35 27 35074 287683 79421604
Forced expiratory volume decreased 56.74 13.35 38 35063 7776 79701511
Paradoxical drug reaction 54.73 13.35 36 35065 7149 79702138
Erythema 54.15 13.35 218 34883 223072 79486215
Nephrolithiasis 53.20 13.35 89 35012 53202 79656085
Reversible airways obstruction 51.07 13.35 23 35078 2153 79707134
Somatic delusion 51.07 13.35 17 35084 701 79708586
Traumatic coma 49.39 13.35 10 35091 50 79709237
Headache 47.83 13.35 468 34633 653304 79055983
Treatment failure 47.52 13.35 174 34927 170312 79538975
Acute kidney injury 47.01 13.35 99 35002 519305 79189982
Drug abuse 45.30 13.35 166 34935 162525 79546762
Pancytopenia 45.18 13.35 9 35092 165736 79543551
Suspected suicide 44.37 13.35 37 35064 10539 79698748
Deformity 43.22 13.35 35 35066 9570 79699717
Prescribed overdose 41.51 13.35 66 35035 37817 79671470
Foetal death 39.81 13.35 31 35070 8013 79701274
Leukopenia 39.80 13.35 3 35098 116510 79592777
Blood potassium increased 39.19 13.35 56 35045 29219 79680068
Vascular malformation 38.90 13.35 12 35089 386 79708901
Sleep disorder 38.26 13.35 103 34998 85574 79623713
Fatigue 38.19 13.35 597 34504 929130 78780157
Serotonin syndrome 38.18 13.35 70 35031 44957 79664330
Interstitial lung disease 38.18 13.35 3 35098 112597 79596690
Pain 37.78 13.35 474 34627 703328 79005959
Cardio-respiratory arrest 37.47 13.35 119 34982 108391 79600896
Paranasal cyst 37.32 13.35 12 35089 443 79708844
Suicidal ideation 36.35 13.35 94 35007 76246 79633041
General physical health deterioration 35.82 13.35 41 35060 275197 79434090
Bone density abnormal 35.31 13.35 20 35081 3040 79706247
Dry eye 34.64 13.35 60 35041 36871 79672416
Mastoiditis 33.72 13.35 16 35085 1688 79707599
Skin lesion 32.92 13.35 63 35038 41781 79667506
Respiratory depression 32.87 13.35 50 35051 27580 79681707
Drug ineffective 32.61 13.35 661 34440 1080252 78629035
Unresponsive to stimuli 32.22 13.35 74 35027 55714 79653573
Pericarditis 32.15 13.35 4 35097 104232 79605055
Obsessive-compulsive disorder 31.88 13.35 24 35077 5903 79703384
Osteoarthritis 31.29 13.35 97 35004 87212 79622075
Feelings of worthlessness 31.18 13.35 11 35090 541 79708746
Polymyositis 30.15 13.35 18 35083 3018 79706269
Exostosis 29.88 13.35 37 35064 16821 79692466
Extrapyramidal disorder 29.79 13.35 43 35058 22636 79686651
Major depression 28.84 13.35 27 35074 8953 79700334
Spinal stenosis 28.54 13.35 35 35066 15756 79693531
Systemic lupus erythematosus 28.34 13.35 9 35092 121140 79588147
Renal failure 28.30 13.35 28 35073 200940 79508347
Unmasking of previously unidentified disease 28.02 13.35 15 35086 2042 79707245
Lower respiratory tract infection 27.84 13.35 11 35090 129209 79580078
Pyrexia 27.75 13.35 180 34921 678529 79030758
Occult blood 27.58 13.35 14 35087 1709 79707578
Pneumonia 26.54 13.35 176 34925 660070 79049217
Femoral neck fracture 26.42 13.35 27 35074 9957 79699330
Cardiac failure 26.23 13.35 18 35083 154824 79554463
Hyperkalaemia 25.88 13.35 9 35092 114389 79594898
Hypoventilation 25.70 13.35 23 35078 7201 79702086
Carpal tunnel syndrome 25.62 13.35 37 35064 19491 79689796
Vomiting 25.51 13.35 180 34921 665648 79043639
Sepsis 25.48 13.35 50 35051 269378 79439909
Glossodynia 25.41 13.35 7 35094 103330 79605957
Swelling 25.35 13.35 35 35066 216676 79492611
Contraindicated product administered 25.01 13.35 136 34965 157402 79551885
Wound 24.84 13.35 10 35091 116169 79593118
Abnormal faeces 24.77 13.35 23 35078 7548 79701739
Multiple organ dysfunction syndrome 24.67 13.35 11 35090 120235 79589052
Abulia 24.64 13.35 11 35090 1009 79708278
Atrial fibrillation 24.12 13.35 31 35070 197855 79511432
Alanine aminotransferase increased 23.65 13.35 22 35079 162548 79546739
Aspartate aminotransferase increased 23.64 13.35 16 35085 138625 79570662
Stomatitis 23.63 13.35 18 35083 146739 79562548
Respiratory arrest 23.52 13.35 67 35034 57483 79651804
Cervicogenic headache 23.14 13.35 5 35096 36 79709251
Ascites 23.06 13.35 3 35098 75559 79633728
Cardiac arrest 23.04 13.35 142 34959 171954 79537333
Malignant neoplasm progression 22.78 13.35 16 35085 135974 79573313
Decreased appetite 22.76 13.35 76 35025 342342 79366945
Disease progression 22.35 13.35 29 35072 184333 79524954
Accidental death 22.25 13.35 17 35084 4274 79705013
Anuria 22.25 13.35 36 35065 20927 79688360
Psoriasis 22.11 13.35 88 35013 89499 79619788
Hyperaesthesia 21.94 13.35 27 35074 12195 79697092
Liver disorder 21.80 13.35 3 35098 72414 79636873
Substance abuse 21.78 13.35 25 35076 10501 79698786
Heart rate increased 21.78 13.35 108 34993 120616 79588671
Impaired quality of life 21.47 13.35 29 35072 14357 79694930
Failed induction of labour 21.28 13.35 7 35094 278 79709009
Adverse reaction 20.77 13.35 23 35078 9291 79699996
Drug intolerance 20.66 13.35 192 34909 263927 79445360
Pleural rub 20.48 13.35 5 35096 65 79709222
Postmortem blood drug level increased 20.43 13.35 9 35092 800 79708487
Oedema peripheral 20.42 13.35 51 35050 252237 79457050
International normalised ratio increased 20.34 13.35 6 35095 84715 79624572
Blood pressure abnormal 20.32 13.35 31 35070 17138 79692149
Alanine aminotransferase abnormal 19.95 13.35 22 35079 8845 79700442
Dyspnoea 19.92 13.35 262 34839 856763 78852524
Oral discomfort 19.89 13.35 23 35078 9737 79699550
Septic shock 19.85 13.35 15 35086 122786 79586501
Pleural effusion 19.58 13.35 21 35080 145241 79564046
Delirium 19.20 13.35 81 35020 84546 79624741
Underdose 19.17 13.35 44 35057 33107 79676180
Gastrointestinal motility disorder 18.88 13.35 18 35083 6104 79703183
Electrocardiogram repolarisation abnormality 18.84 13.35 12 35089 2255 79707032
Mucosal inflammation 18.80 13.35 5 35096 75575 79633712
Blister 18.79 13.35 15 35086 119461 79589826
Lactic acidosis 18.79 13.35 4 35097 70355 79638932
Ventricular tachyarrhythmia 18.79 13.35 7 35094 403 79708884
Urine odour abnormal 18.51 13.35 18 35083 6255 79703032
Platelet count decreased 17.65 13.35 37 35064 194627 79514660
Electrocardiogram ST segment elevation 17.47 13.35 20 35081 8377 79700910
Hepatic failure 17.37 13.35 3 35098 61209 79648078
Binocular eye movement disorder 17.26 13.35 5 35096 129 79709158
Melaena 17.24 13.35 3 35098 60887 79648400
Intentional overdose 17.17 13.35 92 35009 105868 79603419
Antidepressant discontinuation syndrome 17.16 13.35 4 35097 42 79709245
Maternal exposure during pregnancy 17.04 13.35 21 35080 136517 79572770
Multiple sclerosis relapse 16.94 13.35 52 35049 46481 79662806
Rheumatoid factor positive 16.83 13.35 3 35098 59836 79649451
Benzodiazepine drug level therapeutic 16.68 13.35 4 35097 48 79709239
Bone hypertrophy 16.47 13.35 7 35094 570 79708717
Threatened labour 15.94 13.35 7 35094 617 79708670
Blood creatine phosphokinase increased 15.29 13.35 5 35096 66085 79643202
Gastrointestinal haemorrhage 15.21 13.35 26 35075 147693 79561594
Helicobacter infection 14.90 13.35 6 35095 69698 79639589
Essential tremor 14.87 13.35 9 35092 1546 79707741
Hypokalaemia 14.25 13.35 26 35075 144014 79565273
Immune thrombocytopenia 14.24 13.35 27 35074 17778 79691509
Blood glucose increased 14.02 13.35 18 35083 114957 79594330
Anxiety 13.95 13.35 169 34932 248343 79460944
C-reactive protein increased 13.95 13.35 22 35079 129005 79580282
Phonophobia 13.87 13.35 6 35095 510 79708777
Intentional product misuse 13.67 13.35 80 35021 95085 79614202
May-Thurner syndrome 13.50 13.35 3 35098 25 79709262
Dyspepsia 13.50 13.35 88 35013 108599 79600688
Ventricular arrhythmia 13.46 13.35 18 35083 8822 79700465
Musculoskeletal discomfort 13.37 13.35 28 35073 19807 79689480

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Trismus 58.08 53.75 16 89 130 89557

Pharmacologic Action:

SourceCodeDescription
ATC N06AA10 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Non-selective monoamine reuptake inhibitors
MeSH PA D018663 Adrenergic Agents
MeSH PA D018759 Adrenergic Uptake Inhibitors
MeSH PA D000928 Antidepressive Agents
MeSH PA D000929 Antidepressive Agents, Tricyclic
MeSH PA D002491 Central Nervous System Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D011619 Psychotropic Drugs
CHEBI has role CHEBI:35469 antidepressants
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35640 adrenergic uptake inhibitors
CHEBI has role CHEBI:49103 drug metabolites
CHEBI has role CHEBI:68495 Type I cell-death inducers
CHEBI has role CHEBI:176497 geroprotectors
FDA EPC N0000175752 Tricyclic Antidepressant

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Depressive disorder indication 35489007
Neuropathic pain off-label use 247398009
Smoking cessation assistance off-label use 384742004
Attention deficit hyperactivity disorder off-label use 406506008
Suicidal thoughts contraindication 6471006
Alcoholism contraindication 7200002
Sinus tachycardia contraindication 11092001
Lowered convulsive threshold contraindication 19260006
Myocardial infarction contraindication 22298006 DOID:5844
Glaucoma contraindication 23986001 DOID:1686
Torsades de pointes contraindication 31722008
Hyperthyroidism contraindication 34486009 DOID:7998
Renal failure syndrome contraindication 42399005 DOID:1074
Conduction disorder of the heart contraindication 44808001
Hepatic failure contraindication 59927004
Open-angle glaucoma contraindication 84494001 DOID:1067
Epilepsy contraindication 84757009 DOID:1826
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Bipolar affective disorder, current episode manic contraindication 191618007
Cerebrovascular accident contraindication 230690007
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Non-Q wave myocardial infarction contraindication 314207007
Breastfeeding (mother) contraindication 413712001
Myocardial infarction in recovery phase contraindication 418044006
Congenital long QT syndrome contraindication 442917000




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.5 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent noradrenaline transporter Transporter INHIBITOR Kd 8.36 WOMBAT-PK CHEMBL
Sodium-dependent serotonin transporter Transporter INHIBITOR Ki 7.34 WOMBAT-PK CHEMBL
D(1A) dopamine receptor GPCR Ki 6.57 DRUG MATRIX
D(2) dopamine receptor GPCR Ki 5.59 PDSP
Alpha-2A adrenergic receptor GPCR Ki 6.56 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR Ki 6.51 WOMBAT-PK
5-hydroxytryptamine receptor 2A GPCR Ki 7.36 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR Ki 7.07 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 8 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 6.67 CHEMBL
D(3) dopamine receptor GPCR Ki 7.22 DRUG MATRIX
Histamine H1 receptor GPCR Kd 8.03 WOMBAT-PK
Histamine H2 receptor GPCR Ki 5.64 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 7.40 WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR Ki 6.96 WOMBAT-PK
Muscarinic acetylcholine receptor M3 GPCR Ki 7.30 WOMBAT-PK
Muscarinic acetylcholine receptor M4 GPCR Ki 7.08 WOMBAT-PK
Muscarinic acetylcholine receptor M5 GPCR Ki 7.01 WOMBAT-PK
Aldehyde oxidase Enzyme IC50 6.07 WOMBAT-PK
Alpha-2C adrenergic receptor GPCR Ki 7.52 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.92 PDSP
Cytochrome P450 2D6 Enzyme Km 6.23 WOMBAT-PK
Alpha-1D adrenergic receptor GPCR Ki 6.91 DRUG MATRIX
Cytochrome P450 2C19 Enzyme IC50 5.52 DRUG MATRIX
Proto-oncogene tyrosine-protein kinase receptor Ret Kinase IC50 5.82 CHEMBL
Voltage-dependent N-type calcium channel subunit alpha-1B Ion channel IC50 5 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 7.26 WOMBAT-PK
ATP-sensitive inward rectifier potassium channel 10 Ion channel BLOCKER IC50 4.80 SCIENTIFIC LITERATURE
Alpha-2B adrenergic receptor GPCR Ki 7 WOMBAT-PK
Alpha-1B adrenergic receptor GPCR Ki 6.94 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR Ki 5.84 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 10.40 CHEMBL
5-hydroxytryptamine receptor 1A GPCR IC50 5.73 CHEMBL
Histamine H1 receptor GPCR IC50 10.30 CHEMBL

External reference:

IDSource
4019860 VUID
N0000147946 NUI
D00816 KEGG_DRUG
894-71-3 SECONDARY_CAS_RN
4017520 VANDF
4019860 VANDF
C0028420 UMLSCUI
CHEBI:7640 CHEBI
21B PDB_CHEM_ID
CHEMBL445 ChEMBL_ID
DB00540 DRUGBANK_ID
CHEMBL1201156 ChEMBL_ID
D009661 MESH_DESCRIPTOR_UI
4543 PUBCHEM_CID
2404 IUPHAR_LIGAND_ID
1328 INN_ID
BL03SY4LXB UNII
203130 RXNORM
2733 MMSL
2740 MMSL
5192 MMSL
d00144 MMSL
001502 NDDF
004601 NDDF
13432000 SNOMEDCT_US
29666006 SNOMEDCT_US
372652004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0810 CAPSULE 10 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0811 CAPSULE 25 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0812 CAPSULE 50 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0813 CAPSULE 75 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-0678 SOLUTION 10 mg ORAL ANDA 19 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-0678 SOLUTION 10 mg ORAL ANDA 19 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-0678 SOLUTION 10 mg ORAL ANDA 19 sections
PAMELOR HUMAN PRESCRIPTION DRUG LABEL 1 0406-9910 CAPSULE 10 mg ORAL NDA 19 sections
PAMELOR HUMAN PRESCRIPTION DRUG LABEL 1 0406-9911 CAPSULE 25 mg ORAL NDA 19 sections
PAMELOR HUMAN PRESCRIPTION DRUG LABEL 1 0406-9912 CAPSULE 50 mg ORAL NDA 19 sections
PAMELOR HUMAN PRESCRIPTION DRUG LABEL 1 0406-9913 CAPSULE 75 mg ORAL NDA 19 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-567 CAPSULE 10 mg ORAL ANDA 18 sections
NORTRIPTYLINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-171 CAPSULE 25 mg ORAL ANDA 16 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-093 CAPSULE 10 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-094 CAPSULE 25 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-599 CAPSULE 50 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-600 CAPSULE 75 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 33261-348 CAPSULE 25 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 33261-532 CAPSULE 10 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 33261-692 CAPSULE 50 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 33261-804 CAPSULE 75 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-722 CAPSULE 25 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-722 CAPSULE 25 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-897 CAPSULE 25 mg ORAL ANDA 19 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-897 CAPSULE 25 mg ORAL ANDA 19 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 45865-371 CAPSULE 10 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-0507 CAPSULE 25 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-0507 CAPSULE 25 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-0537 CAPSULE 10 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-0537 CAPSULE 10 mg ORAL ANDA 18 sections