nortriptyline ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antidepressants, dibenzo[a,d]cycloheptane or cyclopheptene derivatives 1971 72-69-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nortryptyline
  • nortriptyline
  • demethylamitriptylin
  • desitriptilina
  • desmethylamitriptyline
  • noramitriptyline
  • nortriptyline hydrochloride
  • nortriptyline HCl
A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
  • Molecular weight: 263.38
  • Formula: C19H21N
  • CLOGP: 4.32
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 12.03
  • ALOGS: -5.48
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
75 mg O
30 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 6.34 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 51 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 22 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.12 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 30 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 6, 1964 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Temperature regulation disorder 414.74 13.80 133 26274 4094 50574623
Food allergy 336.57 13.80 135 26272 8002 50570715
Coeliac disease 328.06 13.80 135 26272 8550 50570167
Pneumonia aspiration 317.23 13.80 199 26208 30805 50547912
Completed suicide 286.30 13.80 348 26059 131541 50447176
Immunodeficiency 267.66 13.80 138 26269 14690 50564027
Bursitis 226.16 13.80 142 26265 21993 50556724
Coma 202.29 13.80 195 26212 56684 50522033
Gastrooesophageal reflux disease 184.31 13.80 213 26194 76215 50502502
Rash erythematous 166.25 13.80 141 26266 34711 50544006
Toxicity to various agents 160.81 13.80 347 26060 212152 50366565
Drug hypersensitivity 156.91 13.80 380 26027 250630 50328087
Presbyacusis 146.52 13.80 55 26352 2721 50575996
Asthma 145.70 13.80 205 26202 89132 50489585
Pleural thickening 142.68 13.80 53 26354 2546 50576171
Osteopenia 141.55 13.80 96 26311 16922 50561795
Fluid retention 140.64 13.80 152 26255 50497 50528220
Pleural fibrosis 139.40 13.80 56 26351 3328 50575389
Somnolence 138.26 13.80 271 26136 154714 50424003
Blood magnesium increased 133.83 13.80 52 26355 2828 50575889
Deafness neurosensory 133.61 13.80 59 26348 4442 50574275
Upper respiratory tract infection 125.34 13.80 163 26244 65735 50512982
Hyperhidrosis 110.00 13.80 180 26227 89246 50489471
Epigastric discomfort 104.07 13.80 54 26353 5816 50572901
Neovascularisation 99.85 13.80 32 26375 981 50577736
Bone cyst 88.60 13.80 35 26372 1989 50576728
Rubber sensitivity 81.71 13.80 32 26375 1777 50576940
Brugada syndrome 80.06 13.80 21 26386 309 50578408
Cyst 74.42 13.80 57 26350 12130 50566587
Back pain 72.73 13.80 266 26141 219764 50358953
Paradoxical drug reaction 65.94 13.80 34 26373 3613 50575104
Osteosclerosis 64.65 13.80 33 26374 3434 50575283
Sensitivity to weather change 60.01 13.80 38 26369 5963 50572754
Blood potassium increased 59.69 13.80 57 26350 16341 50562376
Overdose 58.90 13.80 148 26259 99579 50479138
Electrocardiogram QRS complex prolonged 58.90 13.80 36 26371 5308 50573409
Hepatic enzyme increased 58.55 13.80 181 26226 137199 50441518
Rheumatoid arthritis 57.98 13.80 234 26173 202316 50376401
Constipation 55.93 13.80 218 26189 185490 50393227
Poor venous access 55.87 13.80 45 26362 10295 50568422
Hypersensitivity 54.15 13.80 239 26168 214922 50363795
Erythema 52.59 13.80 182 26225 146232 50432485
Forced expiratory volume decreased 52.04 13.80 31 26376 4363 50574354
Traumatic coma 51.51 13.80 11 26396 61 50578656
Migraine 51.19 13.80 118 26289 75162 50503555
Skin lesion 50.59 13.80 66 26341 26661 50552056
Somatic delusion 48.18 13.80 16 26391 550 50578167
Sleep disorder 47.16 13.80 97 26310 57186 50521531
Osteoarthritis 46.05 13.80 107 26300 68499 50510218
Drug ineffective for unapproved indication 45.75 13.80 56 26351 21225 50557492
Glossodynia 42.92 13.80 5 26402 115564 50463153
Dry eye 42.69 13.80 67 26340 32028 50546689
Deformity 41.73 13.80 34 26373 7906 50570811
Polymyositis 38.33 13.80 18 26389 1562 50577155
Systemic lupus erythematosus 36.26 13.80 14 26393 140608 50438109
Neutropenia 36.10 13.80 16 26391 147949 50430768
Bone density abnormal 34.81 13.80 21 26386 3024 50575693
Suspected suicide 34.79 13.80 26 26381 5331 50573386
Exposure during pregnancy 34.77 13.80 10 26397 121005 50457712
Swelling 33.78 13.80 33 26374 200839 50377878
Fatigue 33.53 13.80 536 25871 707065 49871652
Alanine aminotransferase abnormal 33.49 13.80 23 26384 4133 50574584
Anaemia 33.43 13.80 50 26357 252406 50326311
Headache 32.96 13.80 406 26001 506129 50072588
Unmasking of previously unidentified disease 32.47 13.80 13 26394 765 50577952
Exostosis 32.35 13.80 35 26372 11618 50567099
Maternal exposure during pregnancy 32.14 13.80 22 26385 159756 50418961
Extrapyramidal disorder 32.07 13.80 35 26372 11735 50566982
Wound 31.80 13.80 8 26399 105786 50472931
Paranasal cyst 31.79 13.80 10 26397 288 50578429
Vascular malformation 31.63 13.80 10 26397 293 50578424
Spinal stenosis 31.32 13.80 37 26370 13513 50565204
Femoral neck fracture 31.05 13.80 28 26379 7462 50571255
Pancytopenia 30.30 13.80 4 26403 84026 50494691
Occult blood 30.05 13.80 14 26393 1193 50577524
Cardiac arrest 29.14 13.80 103 26304 83548 50495169
Unresponsive to stimuli 29.01 13.80 55 26352 30554 50548163
Anuria 28.16 13.80 32 26375 11212 50567505
Pericarditis 27.77 13.80 4 26403 78685 50500032
Acute kidney injury 27.52 13.80 48 26359 228010 50350707
Lower respiratory tract infection 27.10 13.80 8 26399 95193 50483524
Blood pressure abnormal 26.52 13.80 33 26374 12714 50566003
Febrile neutropenia 26.39 13.80 9 26398 97658 50481059
Carpal tunnel syndrome 26.35 13.80 38 26369 16855 50561862
Accidental death 25.18 13.80 14 26393 1730 50576987
Mastoiditis 24.92 13.80 11 26396 827 50577890
Systolic dysfunction 24.55 13.80 13 26394 1459 50577258
Ventricular tachyarrhythmia 23.85 13.80 6 26401 74 50578643
Suicidal ideation 23.58 13.80 73 26334 55312 50523405
Failed induction of labour 23.25 13.80 8 26399 307 50578410
Electrocardiogram ST segment elevation 22.87 13.80 17 26390 3456 50575261
Leukopenia 22.55 13.80 4 26403 67524 50511193
Vomiting 21.28 13.80 147 26260 460611 50118106
Electrocardiogram repolarisation abnormality 21.15 13.80 11 26396 1189 50577528
Alopecia 21.07 13.80 62 26345 244985 50333732
Delirium 20.79 13.80 55 26352 38137 50540580
Cardiac failure 20.56 13.80 7 26400 76033 50502684
Hyperaesthesia 20.03 13.80 23 26384 8150 50570567
Treatment failure 19.02 13.80 130 26277 137507 50441210
Gastrointestinal motility disorder 18.98 13.80 17 26390 4492 50574225
Hypoventilation 18.96 13.80 16 26391 3905 50574812
Fibromyalgia 18.88 13.80 59 26348 44919 50533798
Oral discomfort 18.71 13.80 22 26385 7995 50570722
Renal failure 18.51 13.80 17 26390 106616 50472101
Postmortem blood drug level increased 18.47 13.80 8 26399 574 50578143
Long QT syndrome 18.38 13.80 14 26393 2953 50575764
Disease progression 18.22 13.80 14 26393 95852 50482865
Pyrexia 18.18 13.80 120 26287 380083 50198634
Essential tremor 18.13 13.80 9 26398 882 50577835
Antidepressant drug level above therapeutic 18.09 13.80 7 26400 376 50578341
Abnormal faeces 18.02 13.80 16 26391 4180 50574537
Sepsis 17.89 13.80 26 26381 132899 50445818
Malignant neoplasm progression 17.19 13.80 7 26400 68117 50510600
Rash 17.15 13.80 146 26261 437325 50141392
Allodynia 17.15 13.80 8 26399 684 50578033
Urine odour abnormal 16.45 13.80 17 26390 5356 50573361
Blood pressure increased 16.22 13.80 122 26285 133010 50445707
Threatened labour 16.17 13.80 8 26399 779 50577938
Dry mouth 16.10 13.80 65 26342 56113 50522604
Pleural rub 16 13.80 4 26403 48 50578669
Stomatitis 15.51 13.80 18 26389 101326 50477391
Noninfectious myelitis 15.28 13.80 3 26404 10 50578707
Heart rate increased 15.17 13.80 80 26327 77170 50501547
Immune thrombocytopenia 15.12 13.80 21 26386 8996 50569721
Respiratory arrest 15.11 13.80 42 26365 29967 50548750
Bone hypertrophy 14.80 13.80 6 26401 365 50578352
Asthenia 14.59 13.80 102 26305 318940 50259777
Pain 14.57 13.80 400 26007 578503 50000214
Procedural pain 14.54 13.80 26 26381 13806 50564911
Adverse reaction 14.41 13.80 20 26387 8566 50570151
Blister 14.38 13.80 14 26393 85404 50493313
Acute lung injury 14.37 13.80 9 26398 1384 50577333
Abdominal discomfort 13.81 13.80 68 26339 231573 50347144

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 296.24 17.07 285 7183 173376 29393683
Completed suicide 162.27 17.07 153 7315 90093 29476966
Sedation 154.00 17.07 79 7389 17326 29549733
Suicidal ideation 90.77 17.07 73 7395 34643 29532416
Myokymia 88.60 17.07 16 7452 76 29566983
Nightmare 68.18 17.07 40 7428 11377 29555682
Nephrolithiasis 51.25 17.07 46 7422 25288 29541771
Drug abuse 50.63 17.07 80 7388 79803 29487256
Electrocardiogram QRS complex prolonged 46.25 17.07 22 7446 4088 29562971
Brugada syndrome 38.78 17.07 12 7456 689 29566370
Hyperhidrosis 33.33 17.07 59 7409 64481 29502578
Drug hypersensitivity 32.11 17.07 60 7408 68346 29498713
Serotonin syndrome 28.14 17.07 28 7440 17484 29549575
Obsessive-compulsive disorder 27.22 17.07 16 7452 4560 29562499
Overdose 26.82 17.07 61 7407 79758 29487301
Impaired quality of life 26.39 17.07 13 7455 2606 29564453
Respiratory depression 26.24 17.07 24 7444 13499 29553560
Reversible airways obstruction 26.00 17.07 7 7461 244 29566815
Feelings of worthlessness 25.57 17.07 7 7461 260 29566799
Depression 25.27 17.07 62 7406 85085 29481974
Binocular eye movement disorder 24.10 17.07 5 7463 54 29567005
Substance abuse 21.47 17.07 16 7452 6771 29560288
Fall 21.45 17.07 95 7373 177083 29389976
Abulia 21.09 17.07 7 7461 504 29566555
Anaemia 20.14 17.07 13 7455 200938 29366121
Suicide attempt 19.98 17.07 33 7435 34077 29532982
Decreased interest 19.74 17.07 10 7458 2128 29564931
Ventricular arrhythmia 19.56 17.07 13 7455 4591 29562468
Drug ineffective 19.41 17.07 157 7311 363013 29204046
Product used for unknown indication 19.20 17.07 6 7462 356 29566703
Major depression 19.18 17.07 12 7456 3823 29563236
Pyrexia 19.05 17.07 27 7441 287595 29279464
Benzodiazepine drug level therapeutic 18.89 17.07 4 7464 48 29567011
Nausea 18.80 17.07 131 7337 289124 29277935
Suspected suicide 18.66 17.07 12 7456 4008 29563051
Vertigo 18.31 17.07 25 7443 21836 29545223
Action tremor 18.19 17.07 4 7464 58 29567001
Inadequate analgesia 17.70 17.07 10 7458 2644 29564415
Cardio-respiratory arrest 17.34 17.07 39 7429 50562 29516497
Postmortem blood drug level increased 17.32 17.07 5 7463 226 29566833
Myoclonus 17.29 17.07 19 7449 13290 29553769

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 434.76 13.58 524 29057 223890 64245261
Temperature regulation disorder 423.64 13.58 131 29450 4080 64465071
Toxicity to various agents 367.21 13.58 622 28959 362891 64106260
Food allergy 350.91 13.58 133 29448 7718 64461433
Coeliac disease 347.38 13.58 130 29451 7282 64461869
Immunodeficiency 267.69 13.58 136 29445 15988 64453163
Bursitis 239.02 13.58 139 29442 21346 64447805
Pneumonia aspiration 210.98 13.58 192 29389 59079 64410072
Drug hypersensitivity 202.12 13.58 378 29203 237437 64231714
Gastrooesophageal reflux disease 156.89 13.58 192 29389 82951 64386200
Coma 145.75 13.58 190 29391 87425 64381726
Presbyacusis 142.26 13.58 51 29530 2524 64466627
Rash erythematous 139.70 13.58 140 29441 48493 64420658
Asthma 139.34 13.58 194 29387 95031 64374120
Osteopenia 130.45 13.58 84 29497 15456 64453695
Fluid retention 129.55 13.58 148 29433 59458 64409693
Pleural thickening 128.66 13.58 48 29533 2662 64466489
Hyperhidrosis 124.40 13.58 213 29368 124707 64344444
Upper respiratory tract infection 122.83 13.58 159 29422 72626 64396525
Pleural fibrosis 119.84 13.58 51 29530 3999 64465152
Somnolence 118.11 13.58 277 29304 203368 64265783
Blood magnesium increased 116.99 13.58 47 29534 3184 64465967
Deafness neurosensory 109.37 13.58 55 29526 6319 64462832
Brugada syndrome 106.14 13.58 33 29548 1045 64468106
Neovascularisation 101.23 13.58 32 29549 1071 64468080
Rubber sensitivity 95.30 13.58 32 29549 1300 64467851
Electrocardiogram QRS complex prolonged 92.82 13.58 56 29525 9188 64459963
Rheumatoid arthritis 92.51 13.58 221 29360 164073 64305078
Bone cyst 90.20 13.58 35 29546 2162 64466989
Epigastric discomfort 86.30 13.58 48 29533 6763 64462388
Overdose 77.58 13.58 203 29378 159363 64309788
Myokymia 75.09 13.58 16 29565 102 64469049
Back pain 74.49 13.58 268 29313 249903 64219248
Hepatic enzyme increased 74.42 13.58 176 29405 129767 64339384
Hypersensitivity 74.11 13.58 228 29353 196224 64272927
Osteosclerosis 68.52 13.58 33 29548 3453 64465698
Cyst 67.98 13.58 51 29530 11976 64457175
Migraine 62.48 13.58 107 29474 62570 64406581
Anaemia 61.68 13.58 50 29531 378630 64090521
Sedation 61.37 13.58 85 29496 41377 64427774
Sensitivity to weather change 58.09 13.58 37 29544 6677 64462474
Poor venous access 55.82 13.58 46 29535 12371 64456780
Febrile neutropenia 54.64 13.58 10 29571 187647 64281504
Neutropenia 52.64 13.58 22 29559 239602 64229549
Sleep disorder 51.88 13.58 96 29485 59613 64409538
Constipation 50.76 13.58 224 29357 229113 64240038
Deformity 50.29 13.58 33 29548 6264 64462887
Traumatic coma 48.98 13.58 10 29571 50 64469101
Paradoxical drug reaction 48.70 13.58 32 29549 6088 64463063
Drug ineffective for unapproved indication 47.84 13.58 65 29516 31068 64438083
Somatic delusion 47.09 13.58 16 29565 674 64468477
Forced expiratory volume decreased 45.36 13.58 32 29549 6835 64462316
Osteoarthritis 44.34 13.58 93 29488 63243 64405908
Acute kidney injury 42.56 13.58 89 29492 449151 64020000
Pain 39.86 13.58 408 29173 553103 63916048
Fatigue 39.71 13.58 520 29061 748210 63720941
Blood potassium increased 39.55 13.58 54 29527 25926 64443225
Erythema 39.32 13.58 180 29401 186890 64282261
Dry eye 39.25 13.58 57 29524 28962 64440189
Pancytopenia 38.89 13.58 9 29572 143300 64325851
Suspected suicide 38.77 13.58 32 29549 8622 64460529
Treatment failure 38.03 13.58 129 29452 116687 64352464
Pyrexia 37.60 13.58 131 29450 558513 63910638
Headache 37.02 13.58 388 29193 529079 63940072
Exostosis 36.69 13.58 35 29546 11403 64457748
Bone density abnormal 36.57 13.58 20 29561 2725 64466426
Drug abuse 36.13 13.58 138 29443 132236 64336915
Skin lesion 35.98 13.58 62 29519 36420 64432731
Leukopenia 35.25 13.58 3 29578 101239 64367912
Suicidal ideation 34.71 13.58 87 29494 66455 64402696
Vascular malformation 32.93 13.58 10 29571 292 64468859
Thrombocytopenia 32.28 13.58 33 29548 223768 64245383
Paranasal cyst 31.65 13.58 10 29571 334 64468817
Respiratory depression 31.64 13.58 46 29535 23397 64445754
Polymyositis 31.36 13.58 18 29563 2692 64466459
Occult blood 29.78 13.58 14 29567 1388 64467763
Cardiac failure 29.30 13.58 12 29569 132361 64336790
Spinal stenosis 29.24 13.58 34 29547 13897 64455254
Carpal tunnel syndrome 28.92 13.58 36 29545 15792 64453359
Femoral neck fracture 28.56 13.58 27 29554 8697 64460454
Unresponsive to stimuli 27.46 13.58 67 29514 50326 64418825
Extrapyramidal disorder 27.31 13.58 39 29542 19513 64449638
Nightmare 25.20 13.58 39 29542 20954 64448197
Abnormal faeces 24.87 13.58 21 29560 5838 64463313
Renal failure 24.84 13.58 28 29553 181660 64287491
Unmasking of previously unidentified disease 24.75 13.58 13 29568 1634 64467517
Delirium 23.92 13.58 78 29503 69116 64400035
Alanine aminotransferase abnormal 23.86 13.58 22 29559 6866 64462285
Accidental death 23.77 13.58 17 29564 3708 64465443
Substance abuse 23.50 13.58 25 29556 9267 64459884
Blood pressure abnormal 23.49 13.58 31 29550 14404 64454747
Major depression 23.34 13.58 23 29558 7793 64461358
Sepsis 23.17 13.58 44 29537 230297 64238854
Hyperkalaemia 22.65 13.58 9 29572 101120 64368031
Failed induction of labour 22.12 13.58 7 29574 235 64468916
Dry mouth 21.69 13.58 69 29512 60349 64408802
Pneumonia 21.68 13.58 159 29422 559417 63909734
Atrial fibrillation 21.66 13.58 28 29553 171061 64298090
Intentional overdose 21.50 13.58 90 29491 89854 64379297
Contraindicated product administered 21.34 13.58 102 29479 107727 64361424
Cardio-respiratory arrest 20.89 13.58 95 29486 98298 64370853
Exposure during pregnancy 20.82 13.58 5 29576 77670 64391481
Postmortem blood drug level increased 20.60 13.58 9 29572 752 64468399
Mastoiditis 20.57 13.58 11 29570 1434 64467717
Oral discomfort 20.18 13.58 22 29559 8384 64460767
Obsessive-compulsive disorder 19.90 13.58 17 29564 4801 64464350
General physical health deterioration 19.73 13.58 40 29541 204385 64264766
Multiple organ dysfunction syndrome 19.67 13.58 11 29570 101402 64367749
International normalised ratio increased 19.52 13.58 6 29575 79161 64389990
Malignant neoplasm progression 19.48 13.58 14 29567 112857 64356294
Alanine aminotransferase increased 19.47 13.58 21 29560 139010 64330141
Respiratory arrest 19.47 13.58 61 29520 52924 64416227
Vomiting 19.29 13.58 161 29420 550956 63918195
Aspartate aminotransferase increased 19.23 13.58 16 29565 119772 64349379
Urine odour abnormal 18.96 13.58 17 29564 5119 64464032
Fibromyalgia 18.92 13.58 47 29534 35684 64433467
Gastrointestinal motility disorder 18.84 13.58 17 29564 5162 64463989
Lower respiratory tract infection 18.74 13.58 10 29571 94604 64374547
Ascites 18.70 13.58 3 29578 61998 64407153
Hyperaesthesia 18.65 13.58 23 29558 9991 64459160
Nephrolithiasis 18.61 13.58 53 29528 43630 64425521
Heart rate increased 18.56 13.58 92 29489 98583 64370568
Anuria 18.39 13.58 32 29549 18932 64450219
Adverse reaction 18.24 13.58 20 29561 7667 64461484
Cardiac arrest 18.18 13.58 127 29454 153937 64315214
Binocular eye movement disorder 18.12 13.58 5 29576 103 64469048
Electrocardiogram repolarisation abnormality 17.86 13.58 11 29570 1871 64467280
Ventricular tachyarrhythmia 17.68 13.58 6 29575 252 64468899
Decreased appetite 17.53 13.58 68 29513 281221 64187930
Electrocardiogram ST segment elevation 17.43 13.58 19 29562 7240 64461911
Feelings of worthlessness 17.35 13.58 7 29574 479 64468672
Oedema peripheral 17.19 13.58 45 29536 210272 64258879
Reversible airways obstruction 17.15 13.58 9 29572 1129 64468022
Pleural rub 16.92 13.58 4 29577 43 64469108
Pericarditis 16.80 13.58 4 29577 62512 64406639
Prescribed overdose 16.79 13.58 32 29549 20299 64448852
Pleural effusion 16.76 13.58 20 29561 126539 64342612
Multiple sclerosis relapse 16.65 13.58 49 29532 41086 64428065
Benzodiazepine drug level therapeutic 16.51 13.58 4 29577 48 64469103
Lactic acidosis 16.37 13.58 4 29577 61406 64407745
Threatened labour 16.33 13.58 7 29574 558 64468593
Bone hypertrophy 16.30 13.58 6 29575 320 64468831
Drug ineffective 16.07 13.58 501 29080 839746 63629405
Hepatic failure 16.01 13.58 3 29578 55391 64413760
Essential tremor 15.91 13.58 9 29572 1310 64467841
Septic shock 15.82 13.58 15 29566 105422 64363729
Swelling 15.76 13.58 31 29550 160187 64308964
Systemic lupus erythematosus 15.67 13.58 8 29573 77604 64391547
Impaired quality of life 15.64 13.58 17 29564 6454 64462697
Ventricular arrhythmia 15.40 13.58 18 29563 7397 64461754
Melaena 15.26 13.58 3 29578 53545 64415606
Platelet count decreased 15.19 13.58 34 29547 167677 64301474
Dyspepsia 15.19 13.58 75 29506 80237 64388914
Disease progression 15.19 13.58 26 29555 141654 64327497
Liver disorder 15.18 13.58 3 29578 53348 64415803
Mucosal inflammation 14.98 13.58 5 29576 62579 64406572
Hypoventilation 14.91 13.58 16 29565 5990 64463161
Stomatitis 14.86 13.58 17 29564 109588 64359563
Blood pressure increased 14.21 13.58 131 29450 172421 64296730
Anxiety 13.85 13.58 148 29433 202501 64266650
Wound 13.84 13.58 9 29572 76468 64392683

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N06AA10 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Non-selective monoamine reuptake inhibitors
MeSH PA D018663 Adrenergic Agents
MeSH PA D018759 Adrenergic Uptake Inhibitors
MeSH PA D000928 Antidepressive Agents
MeSH PA D000929 Antidepressive Agents, Tricyclic
MeSH PA D002491 Central Nervous System Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014179 Neurotransmitter Uptake Inhibitors
MeSH PA D011619 Psychotropic Drugs
CHEBI has role CHEBI:35469 antidepressants
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35640 adrenergic uptake inhibitors
CHEBI has role CHEBI:49103 drug metabolites
CHEBI has role CHEBI:68495 Type I cell-death inducers
CHEBI has role CHEBI:176497 geroprotectors
FDA EPC N0000175752 Tricyclic Antidepressant

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Depressive disorder indication 35489007
Neuropathic pain off-label use 247398009
Smoking cessation assistance off-label use 384742004
Attention deficit hyperactivity disorder off-label use 406506008
Suicidal thoughts contraindication 6471006
Alcoholism contraindication 7200002
Sinus tachycardia contraindication 11092001
Lowered convulsive threshold contraindication 19260006
Myocardial infarction contraindication 22298006 DOID:5844
Glaucoma contraindication 23986001 DOID:1686
Torsades de pointes contraindication 31722008
Hyperthyroidism contraindication 34486009 DOID:7998
Renal failure syndrome contraindication 42399005 DOID:1074
Conduction disorder of the heart contraindication 44808001
Hepatic failure contraindication 59927004
Open-angle glaucoma contraindication 84494001 DOID:1067
Epilepsy contraindication 84757009 DOID:1826
Prolonged QT interval contraindication 111975006
Seizure disorder contraindication 128613002
Bipolar affective disorder, current episode manic contraindication 191618007
Cerebrovascular accident contraindication 230690007
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Non-Q wave myocardial infarction contraindication 314207007
Breastfeeding (mother) contraindication 413712001
Myocardial infarction in recovery phase contraindication 418044006
Congenital long QT syndrome contraindication 442917000




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.5 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter INHIBITOR Ki 7.34 WOMBAT-PK CHEMBL
Sodium-dependent noradrenaline transporter Transporter INHIBITOR Kd 8.36 WOMBAT-PK CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 6.56 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR Ki 6.51 WOMBAT-PK
5-hydroxytryptamine receptor 2A GPCR Ki 7.36 WOMBAT-PK
5-hydroxytryptamine receptor 2B GPCR Ki 7.07 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 8 WOMBAT-PK
5-hydroxytryptamine receptor 6 GPCR Ki 6.67 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 7.26 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 7 WOMBAT-PK
D(3) dopamine receptor GPCR Ki 7.22 DRUG MATRIX
Histamine H1 receptor GPCR Kd 8.03 WOMBAT-PK
Histamine H2 receptor GPCR Ki 5.64 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 7.40 WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR Ki 6.96 WOMBAT-PK
Muscarinic acetylcholine receptor M3 GPCR Ki 7.30 WOMBAT-PK
Muscarinic acetylcholine receptor M4 GPCR Ki 7.08 WOMBAT-PK
Muscarinic acetylcholine receptor M5 GPCR Ki 7.01 WOMBAT-PK
Aldehyde oxidase Enzyme IC50 6.07 WOMBAT-PK
Alpha-2C adrenergic receptor GPCR Ki 7.52 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.92 PDSP
Cytochrome P450 2D6 Enzyme Km 6.23 WOMBAT-PK
Alpha-1D adrenergic receptor GPCR Ki 6.91 DRUG MATRIX
Cytochrome P450 2C19 Enzyme IC50 5.52 DRUG MATRIX
Proto-oncogene tyrosine-protein kinase receptor Ret Kinase IC50 5.82 CHEMBL
D(1A) dopamine receptor GPCR Ki 6.57 DRUG MATRIX
ATP-sensitive inward rectifier potassium channel 10 Ion channel BLOCKER IC50 4.80 SCIENTIFIC LITERATURE
D(2) dopamine receptor GPCR Ki 5.59 PDSP
Alpha-1B adrenergic receptor GPCR Ki 6.94 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR Ki 5.84 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 10.40 CHEMBL
5-hydroxytryptamine receptor 1A GPCR IC50 5.73 CHEMBL
Histamine H1 receptor GPCR IC50 10.30 CHEMBL

External reference:

IDSource
4019860 VUID
N0000147946 NUI
D00816 KEGG_DRUG
894-71-3 SECONDARY_CAS_RN
4017520 VANDF
4019860 VANDF
C0028420 UMLSCUI
CHEBI:7640 CHEBI
21B PDB_CHEM_ID
CHEMBL445 ChEMBL_ID
DB00540 DRUGBANK_ID
CHEMBL1201156 ChEMBL_ID
D009661 MESH_DESCRIPTOR_UI
4543 PUBCHEM_CID
2404 IUPHAR_LIGAND_ID
1328 INN_ID
BL03SY4LXB UNII
203130 RXNORM
2733 MMSL
2740 MMSL
5192 MMSL
d00144 MMSL
001502 NDDF
004601 NDDF
13432000 SNOMEDCT_US
29666006 SNOMEDCT_US
372652004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0810 CAPSULE 10 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0811 CAPSULE 25 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0812 CAPSULE 50 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-0813 CAPSULE 75 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-0678 SOLUTION 10 mg ORAL ANDA 19 sections
PAMELOR HUMAN PRESCRIPTION DRUG LABEL 1 0406-9910 CAPSULE 10 mg ORAL NDA 19 sections
PAMELOR HUMAN PRESCRIPTION DRUG LABEL 1 0406-9911 CAPSULE 25 mg ORAL NDA 19 sections
PAMELOR HUMAN PRESCRIPTION DRUG LABEL 1 0406-9912 CAPSULE 50 mg ORAL NDA 19 sections
PAMELOR HUMAN PRESCRIPTION DRUG LABEL 1 0406-9913 CAPSULE 75 mg ORAL NDA 19 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-567 CAPSULE 10 mg ORAL ANDA 18 sections
NORTRIPTYLINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 16590-171 CAPSULE 25 mg ORAL ANDA 16 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-093 CAPSULE 10 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-094 CAPSULE 25 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-599 CAPSULE 50 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-600 CAPSULE 75 mg ORAL ANDA 13 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 33261-348 CAPSULE 25 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 33261-532 CAPSULE 10 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 33261-692 CAPSULE 50 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 33261-804 CAPSULE 75 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-722 CAPSULE 25 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-897 CAPSULE 25 mg ORAL ANDA 19 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 45865-371 CAPSULE 10 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-0507 CAPSULE 25 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-0537 CAPSULE 10 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-1323 CAPSULE 50 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50268-603 CAPSULE 10 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50268-604 CAPSULE 25 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50268-605 CAPSULE 50 mg ORAL ANDA 18 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50436-4022 CAPSULE 25 mg ORAL ANDA 17 sections
Nortriptyline Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50436-6652 CAPSULE 10 mg ORAL ANDA 18 sections