All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

nortriptyline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antidepressants, dibenzo[a,d]cycloheptane or cyclopheptene derivatives	1971	72-69-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: nortryptyline nortriptyline demethylamitriptylin desitriptilina desmethylamitriptyline noramitriptyline nortriptyline hydrochloride nortriptyline HCl	A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions. Molecular weight: 263.38 Formula: C19H21N CLOGP: 4.32 LIPINSKI: 0 HAC: 1 HDO: 1 TPSA: 12.03 ALOGS: -5.48 ROTB: 3 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
75	mg	O
30	mg	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	2 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	6.34 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	51 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	22 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	10 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.12 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	30 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Nov. 6, 1964	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Temperature regulation disorder	414.74	13.80	133	26274	4094	50574623
Food allergy	336.57	13.80	135	26272	8002	50570715
Coeliac disease	328.06	13.80	135	26272	8550	50570167
Pneumonia aspiration	317.23	13.80	199	26208	30805	50547912
Completed suicide	286.30	13.80	348	26059	131541	50447176
Immunodeficiency	267.66	13.80	138	26269	14690	50564027
Bursitis	226.16	13.80	142	26265	21993	50556724
Coma	202.29	13.80	195	26212	56684	50522033
Gastrooesophageal reflux disease	184.31	13.80	213	26194	76215	50502502
Rash erythematous	166.25	13.80	141	26266	34711	50544006
Toxicity to various agents	160.81	13.80	347	26060	212152	50366565
Drug hypersensitivity	156.91	13.80	380	26027	250630	50328087
Presbyacusis	146.52	13.80	55	26352	2721	50575996
Asthma	145.70	13.80	205	26202	89132	50489585
Pleural thickening	142.68	13.80	53	26354	2546	50576171
Osteopenia	141.55	13.80	96	26311	16922	50561795
Fluid retention	140.64	13.80	152	26255	50497	50528220
Pleural fibrosis	139.40	13.80	56	26351	3328	50575389
Somnolence	138.26	13.80	271	26136	154714	50424003
Blood magnesium increased	133.83	13.80	52	26355	2828	50575889
Deafness neurosensory	133.61	13.80	59	26348	4442	50574275
Upper respiratory tract infection	125.34	13.80	163	26244	65735	50512982
Hyperhidrosis	110.00	13.80	180	26227	89246	50489471
Epigastric discomfort	104.07	13.80	54	26353	5816	50572901
Neovascularisation	99.85	13.80	32	26375	981	50577736
Bone cyst	88.60	13.80	35	26372	1989	50576728
Rubber sensitivity	81.71	13.80	32	26375	1777	50576940
Brugada syndrome	80.06	13.80	21	26386	309	50578408
Cyst	74.42	13.80	57	26350	12130	50566587
Back pain	72.73	13.80	266	26141	219764	50358953
Paradoxical drug reaction	65.94	13.80	34	26373	3613	50575104
Osteosclerosis	64.65	13.80	33	26374	3434	50575283
Sensitivity to weather change	60.01	13.80	38	26369	5963	50572754
Blood potassium increased	59.69	13.80	57	26350	16341	50562376
Overdose	58.90	13.80	148	26259	99579	50479138
Electrocardiogram QRS complex prolonged	58.90	13.80	36	26371	5308	50573409
Hepatic enzyme increased	58.55	13.80	181	26226	137199	50441518
Rheumatoid arthritis	57.98	13.80	234	26173	202316	50376401
Constipation	55.93	13.80	218	26189	185490	50393227
Poor venous access	55.87	13.80	45	26362	10295	50568422
Hypersensitivity	54.15	13.80	239	26168	214922	50363795
Erythema	52.59	13.80	182	26225	146232	50432485
Forced expiratory volume decreased	52.04	13.80	31	26376	4363	50574354
Traumatic coma	51.51	13.80	11	26396	61	50578656
Migraine	51.19	13.80	118	26289	75162	50503555
Skin lesion	50.59	13.80	66	26341	26661	50552056
Somatic delusion	48.18	13.80	16	26391	550	50578167
Sleep disorder	47.16	13.80	97	26310	57186	50521531
Osteoarthritis	46.05	13.80	107	26300	68499	50510218
Drug ineffective for unapproved indication	45.75	13.80	56	26351	21225	50557492
Glossodynia	42.92	13.80	5	26402	115564	50463153
Dry eye	42.69	13.80	67	26340	32028	50546689
Deformity	41.73	13.80	34	26373	7906	50570811
Polymyositis	38.33	13.80	18	26389	1562	50577155
Systemic lupus erythematosus	36.26	13.80	14	26393	140608	50438109
Neutropenia	36.10	13.80	16	26391	147949	50430768
Bone density abnormal	34.81	13.80	21	26386	3024	50575693
Suspected suicide	34.79	13.80	26	26381	5331	50573386
Exposure during pregnancy	34.77	13.80	10	26397	121005	50457712
Swelling	33.78	13.80	33	26374	200839	50377878
Fatigue	33.53	13.80	536	25871	707065	49871652
Alanine aminotransferase abnormal	33.49	13.80	23	26384	4133	50574584
Anaemia	33.43	13.80	50	26357	252406	50326311
Headache	32.96	13.80	406	26001	506129	50072588
Unmasking of previously unidentified disease	32.47	13.80	13	26394	765	50577952
Exostosis	32.35	13.80	35	26372	11618	50567099
Maternal exposure during pregnancy	32.14	13.80	22	26385	159756	50418961
Extrapyramidal disorder	32.07	13.80	35	26372	11735	50566982
Wound	31.80	13.80	8	26399	105786	50472931
Paranasal cyst	31.79	13.80	10	26397	288	50578429
Vascular malformation	31.63	13.80	10	26397	293	50578424
Spinal stenosis	31.32	13.80	37	26370	13513	50565204
Femoral neck fracture	31.05	13.80	28	26379	7462	50571255
Pancytopenia	30.30	13.80	4	26403	84026	50494691
Occult blood	30.05	13.80	14	26393	1193	50577524
Cardiac arrest	29.14	13.80	103	26304	83548	50495169
Unresponsive to stimuli	29.01	13.80	55	26352	30554	50548163
Anuria	28.16	13.80	32	26375	11212	50567505
Pericarditis	27.77	13.80	4	26403	78685	50500032
Acute kidney injury	27.52	13.80	48	26359	228010	50350707
Lower respiratory tract infection	27.10	13.80	8	26399	95193	50483524
Blood pressure abnormal	26.52	13.80	33	26374	12714	50566003
Febrile neutropenia	26.39	13.80	9	26398	97658	50481059
Carpal tunnel syndrome	26.35	13.80	38	26369	16855	50561862
Accidental death	25.18	13.80	14	26393	1730	50576987
Mastoiditis	24.92	13.80	11	26396	827	50577890
Systolic dysfunction	24.55	13.80	13	26394	1459	50577258
Ventricular tachyarrhythmia	23.85	13.80	6	26401	74	50578643
Suicidal ideation	23.58	13.80	73	26334	55312	50523405
Failed induction of labour	23.25	13.80	8	26399	307	50578410
Electrocardiogram ST segment elevation	22.87	13.80	17	26390	3456	50575261
Leukopenia	22.55	13.80	4	26403	67524	50511193
Vomiting	21.28	13.80	147	26260	460611	50118106
Electrocardiogram repolarisation abnormality	21.15	13.80	11	26396	1189	50577528
Alopecia	21.07	13.80	62	26345	244985	50333732
Delirium	20.79	13.80	55	26352	38137	50540580
Cardiac failure	20.56	13.80	7	26400	76033	50502684
Hyperaesthesia	20.03	13.80	23	26384	8150	50570567
Treatment failure	19.02	13.80	130	26277	137507	50441210
Gastrointestinal motility disorder	18.98	13.80	17	26390	4492	50574225
Hypoventilation	18.96	13.80	16	26391	3905	50574812
Fibromyalgia	18.88	13.80	59	26348	44919	50533798
Oral discomfort	18.71	13.80	22	26385	7995	50570722
Renal failure	18.51	13.80	17	26390	106616	50472101
Postmortem blood drug level increased	18.47	13.80	8	26399	574	50578143
Long QT syndrome	18.38	13.80	14	26393	2953	50575764
Disease progression	18.22	13.80	14	26393	95852	50482865
Pyrexia	18.18	13.80	120	26287	380083	50198634
Essential tremor	18.13	13.80	9	26398	882	50577835
Antidepressant drug level above therapeutic	18.09	13.80	7	26400	376	50578341
Abnormal faeces	18.02	13.80	16	26391	4180	50574537
Sepsis	17.89	13.80	26	26381	132899	50445818
Malignant neoplasm progression	17.19	13.80	7	26400	68117	50510600
Rash	17.15	13.80	146	26261	437325	50141392
Allodynia	17.15	13.80	8	26399	684	50578033
Urine odour abnormal	16.45	13.80	17	26390	5356	50573361
Blood pressure increased	16.22	13.80	122	26285	133010	50445707
Threatened labour	16.17	13.80	8	26399	779	50577938
Dry mouth	16.10	13.80	65	26342	56113	50522604
Pleural rub	16	13.80	4	26403	48	50578669
Stomatitis	15.51	13.80	18	26389	101326	50477391
Noninfectious myelitis	15.28	13.80	3	26404	10	50578707
Heart rate increased	15.17	13.80	80	26327	77170	50501547
Immune thrombocytopenia	15.12	13.80	21	26386	8996	50569721
Respiratory arrest	15.11	13.80	42	26365	29967	50548750
Bone hypertrophy	14.80	13.80	6	26401	365	50578352
Asthenia	14.59	13.80	102	26305	318940	50259777
Pain	14.57	13.80	400	26007	578503	50000214
Procedural pain	14.54	13.80	26	26381	13806	50564911
Adverse reaction	14.41	13.80	20	26387	8566	50570151
Blister	14.38	13.80	14	26393	85404	50493313
Acute lung injury	14.37	13.80	9	26398	1384	50577333
Abdominal discomfort	13.81	13.80	68	26339	231573	50347144

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxicity to various agents	296.24	17.07	285	7183	173376	29393683
Completed suicide	162.27	17.07	153	7315	90093	29476966
Sedation	154.00	17.07	79	7389	17326	29549733
Suicidal ideation	90.77	17.07	73	7395	34643	29532416
Myokymia	88.60	17.07	16	7452	76	29566983
Nightmare	68.18	17.07	40	7428	11377	29555682
Nephrolithiasis	51.25	17.07	46	7422	25288	29541771
Drug abuse	50.63	17.07	80	7388	79803	29487256
Electrocardiogram QRS complex prolonged	46.25	17.07	22	7446	4088	29562971
Brugada syndrome	38.78	17.07	12	7456	689	29566370
Hyperhidrosis	33.33	17.07	59	7409	64481	29502578
Drug hypersensitivity	32.11	17.07	60	7408	68346	29498713
Serotonin syndrome	28.14	17.07	28	7440	17484	29549575
Obsessive-compulsive disorder	27.22	17.07	16	7452	4560	29562499
Overdose	26.82	17.07	61	7407	79758	29487301
Impaired quality of life	26.39	17.07	13	7455	2606	29564453
Respiratory depression	26.24	17.07	24	7444	13499	29553560
Reversible airways obstruction	26.00	17.07	7	7461	244	29566815
Feelings of worthlessness	25.57	17.07	7	7461	260	29566799
Depression	25.27	17.07	62	7406	85085	29481974
Binocular eye movement disorder	24.10	17.07	5	7463	54	29567005
Substance abuse	21.47	17.07	16	7452	6771	29560288
Fall	21.45	17.07	95	7373	177083	29389976
Abulia	21.09	17.07	7	7461	504	29566555
Anaemia	20.14	17.07	13	7455	200938	29366121
Suicide attempt	19.98	17.07	33	7435	34077	29532982
Decreased interest	19.74	17.07	10	7458	2128	29564931
Ventricular arrhythmia	19.56	17.07	13	7455	4591	29562468
Drug ineffective	19.41	17.07	157	7311	363013	29204046
Product used for unknown indication	19.20	17.07	6	7462	356	29566703
Major depression	19.18	17.07	12	7456	3823	29563236
Pyrexia	19.05	17.07	27	7441	287595	29279464
Benzodiazepine drug level therapeutic	18.89	17.07	4	7464	48	29567011
Nausea	18.80	17.07	131	7337	289124	29277935
Suspected suicide	18.66	17.07	12	7456	4008	29563051
Vertigo	18.31	17.07	25	7443	21836	29545223
Action tremor	18.19	17.07	4	7464	58	29567001
Inadequate analgesia	17.70	17.07	10	7458	2644	29564415
Cardio-respiratory arrest	17.34	17.07	39	7429	50562	29516497
Postmortem blood drug level increased	17.32	17.07	5	7463	226	29566833
Myoclonus	17.29	17.07	19	7449	13290	29553769

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	434.76	13.58	524	29057	223890	64245261
Temperature regulation disorder	423.64	13.58	131	29450	4080	64465071
Toxicity to various agents	367.21	13.58	622	28959	362891	64106260
Food allergy	350.91	13.58	133	29448	7718	64461433
Coeliac disease	347.38	13.58	130	29451	7282	64461869
Immunodeficiency	267.69	13.58	136	29445	15988	64453163
Bursitis	239.02	13.58	139	29442	21346	64447805
Pneumonia aspiration	210.98	13.58	192	29389	59079	64410072
Drug hypersensitivity	202.12	13.58	378	29203	237437	64231714
Gastrooesophageal reflux disease	156.89	13.58	192	29389	82951	64386200
Coma	145.75	13.58	190	29391	87425	64381726
Presbyacusis	142.26	13.58	51	29530	2524	64466627
Rash erythematous	139.70	13.58	140	29441	48493	64420658
Asthma	139.34	13.58	194	29387	95031	64374120
Osteopenia	130.45	13.58	84	29497	15456	64453695
Fluid retention	129.55	13.58	148	29433	59458	64409693
Pleural thickening	128.66	13.58	48	29533	2662	64466489
Hyperhidrosis	124.40	13.58	213	29368	124707	64344444
Upper respiratory tract infection	122.83	13.58	159	29422	72626	64396525
Pleural fibrosis	119.84	13.58	51	29530	3999	64465152
Somnolence	118.11	13.58	277	29304	203368	64265783
Blood magnesium increased	116.99	13.58	47	29534	3184	64465967
Deafness neurosensory	109.37	13.58	55	29526	6319	64462832
Brugada syndrome	106.14	13.58	33	29548	1045	64468106
Neovascularisation	101.23	13.58	32	29549	1071	64468080
Rubber sensitivity	95.30	13.58	32	29549	1300	64467851
Electrocardiogram QRS complex prolonged	92.82	13.58	56	29525	9188	64459963
Rheumatoid arthritis	92.51	13.58	221	29360	164073	64305078
Bone cyst	90.20	13.58	35	29546	2162	64466989
Epigastric discomfort	86.30	13.58	48	29533	6763	64462388
Overdose	77.58	13.58	203	29378	159363	64309788
Myokymia	75.09	13.58	16	29565	102	64469049
Back pain	74.49	13.58	268	29313	249903	64219248
Hepatic enzyme increased	74.42	13.58	176	29405	129767	64339384
Hypersensitivity	74.11	13.58	228	29353	196224	64272927
Osteosclerosis	68.52	13.58	33	29548	3453	64465698
Cyst	67.98	13.58	51	29530	11976	64457175
Migraine	62.48	13.58	107	29474	62570	64406581
Anaemia	61.68	13.58	50	29531	378630	64090521
Sedation	61.37	13.58	85	29496	41377	64427774
Sensitivity to weather change	58.09	13.58	37	29544	6677	64462474
Poor venous access	55.82	13.58	46	29535	12371	64456780
Febrile neutropenia	54.64	13.58	10	29571	187647	64281504
Neutropenia	52.64	13.58	22	29559	239602	64229549
Sleep disorder	51.88	13.58	96	29485	59613	64409538
Constipation	50.76	13.58	224	29357	229113	64240038
Deformity	50.29	13.58	33	29548	6264	64462887
Traumatic coma	48.98	13.58	10	29571	50	64469101
Paradoxical drug reaction	48.70	13.58	32	29549	6088	64463063
Drug ineffective for unapproved indication	47.84	13.58	65	29516	31068	64438083
Somatic delusion	47.09	13.58	16	29565	674	64468477
Forced expiratory volume decreased	45.36	13.58	32	29549	6835	64462316
Osteoarthritis	44.34	13.58	93	29488	63243	64405908
Acute kidney injury	42.56	13.58	89	29492	449151	64020000
Pain	39.86	13.58	408	29173	553103	63916048
Fatigue	39.71	13.58	520	29061	748210	63720941
Blood potassium increased	39.55	13.58	54	29527	25926	64443225
Erythema	39.32	13.58	180	29401	186890	64282261
Dry eye	39.25	13.58	57	29524	28962	64440189
Pancytopenia	38.89	13.58	9	29572	143300	64325851
Suspected suicide	38.77	13.58	32	29549	8622	64460529
Treatment failure	38.03	13.58	129	29452	116687	64352464
Pyrexia	37.60	13.58	131	29450	558513	63910638
Headache	37.02	13.58	388	29193	529079	63940072
Exostosis	36.69	13.58	35	29546	11403	64457748
Bone density abnormal	36.57	13.58	20	29561	2725	64466426
Drug abuse	36.13	13.58	138	29443	132236	64336915
Skin lesion	35.98	13.58	62	29519	36420	64432731
Leukopenia	35.25	13.58	3	29578	101239	64367912
Suicidal ideation	34.71	13.58	87	29494	66455	64402696
Vascular malformation	32.93	13.58	10	29571	292	64468859
Thrombocytopenia	32.28	13.58	33	29548	223768	64245383
Paranasal cyst	31.65	13.58	10	29571	334	64468817
Respiratory depression	31.64	13.58	46	29535	23397	64445754
Polymyositis	31.36	13.58	18	29563	2692	64466459
Occult blood	29.78	13.58	14	29567	1388	64467763
Cardiac failure	29.30	13.58	12	29569	132361	64336790
Spinal stenosis	29.24	13.58	34	29547	13897	64455254
Carpal tunnel syndrome	28.92	13.58	36	29545	15792	64453359
Femoral neck fracture	28.56	13.58	27	29554	8697	64460454
Unresponsive to stimuli	27.46	13.58	67	29514	50326	64418825
Extrapyramidal disorder	27.31	13.58	39	29542	19513	64449638
Nightmare	25.20	13.58	39	29542	20954	64448197
Abnormal faeces	24.87	13.58	21	29560	5838	64463313
Renal failure	24.84	13.58	28	29553	181660	64287491
Unmasking of previously unidentified disease	24.75	13.58	13	29568	1634	64467517
Delirium	23.92	13.58	78	29503	69116	64400035
Alanine aminotransferase abnormal	23.86	13.58	22	29559	6866	64462285
Accidental death	23.77	13.58	17	29564	3708	64465443
Substance abuse	23.50	13.58	25	29556	9267	64459884
Blood pressure abnormal	23.49	13.58	31	29550	14404	64454747
Major depression	23.34	13.58	23	29558	7793	64461358
Sepsis	23.17	13.58	44	29537	230297	64238854
Hyperkalaemia	22.65	13.58	9	29572	101120	64368031
Failed induction of labour	22.12	13.58	7	29574	235	64468916
Dry mouth	21.69	13.58	69	29512	60349	64408802
Pneumonia	21.68	13.58	159	29422	559417	63909734
Atrial fibrillation	21.66	13.58	28	29553	171061	64298090
Intentional overdose	21.50	13.58	90	29491	89854	64379297
Contraindicated product administered	21.34	13.58	102	29479	107727	64361424
Cardio-respiratory arrest	20.89	13.58	95	29486	98298	64370853
Exposure during pregnancy	20.82	13.58	5	29576	77670	64391481
Postmortem blood drug level increased	20.60	13.58	9	29572	752	64468399
Mastoiditis	20.57	13.58	11	29570	1434	64467717
Oral discomfort	20.18	13.58	22	29559	8384	64460767
Obsessive-compulsive disorder	19.90	13.58	17	29564	4801	64464350
General physical health deterioration	19.73	13.58	40	29541	204385	64264766
Multiple organ dysfunction syndrome	19.67	13.58	11	29570	101402	64367749
International normalised ratio increased	19.52	13.58	6	29575	79161	64389990
Malignant neoplasm progression	19.48	13.58	14	29567	112857	64356294
Alanine aminotransferase increased	19.47	13.58	21	29560	139010	64330141
Respiratory arrest	19.47	13.58	61	29520	52924	64416227
Vomiting	19.29	13.58	161	29420	550956	63918195
Aspartate aminotransferase increased	19.23	13.58	16	29565	119772	64349379
Urine odour abnormal	18.96	13.58	17	29564	5119	64464032
Fibromyalgia	18.92	13.58	47	29534	35684	64433467
Gastrointestinal motility disorder	18.84	13.58	17	29564	5162	64463989
Lower respiratory tract infection	18.74	13.58	10	29571	94604	64374547
Ascites	18.70	13.58	3	29578	61998	64407153
Hyperaesthesia	18.65	13.58	23	29558	9991	64459160
Nephrolithiasis	18.61	13.58	53	29528	43630	64425521
Heart rate increased	18.56	13.58	92	29489	98583	64370568
Anuria	18.39	13.58	32	29549	18932	64450219
Adverse reaction	18.24	13.58	20	29561	7667	64461484
Cardiac arrest	18.18	13.58	127	29454	153937	64315214
Binocular eye movement disorder	18.12	13.58	5	29576	103	64469048
Electrocardiogram repolarisation abnormality	17.86	13.58	11	29570	1871	64467280
Ventricular tachyarrhythmia	17.68	13.58	6	29575	252	64468899
Decreased appetite	17.53	13.58	68	29513	281221	64187930
Electrocardiogram ST segment elevation	17.43	13.58	19	29562	7240	64461911
Feelings of worthlessness	17.35	13.58	7	29574	479	64468672
Oedema peripheral	17.19	13.58	45	29536	210272	64258879
Reversible airways obstruction	17.15	13.58	9	29572	1129	64468022
Pleural rub	16.92	13.58	4	29577	43	64469108
Pericarditis	16.80	13.58	4	29577	62512	64406639
Prescribed overdose	16.79	13.58	32	29549	20299	64448852
Pleural effusion	16.76	13.58	20	29561	126539	64342612
Multiple sclerosis relapse	16.65	13.58	49	29532	41086	64428065
Benzodiazepine drug level therapeutic	16.51	13.58	4	29577	48	64469103
Lactic acidosis	16.37	13.58	4	29577	61406	64407745
Threatened labour	16.33	13.58	7	29574	558	64468593
Bone hypertrophy	16.30	13.58	6	29575	320	64468831
Drug ineffective	16.07	13.58	501	29080	839746	63629405
Hepatic failure	16.01	13.58	3	29578	55391	64413760
Essential tremor	15.91	13.58	9	29572	1310	64467841
Septic shock	15.82	13.58	15	29566	105422	64363729
Swelling	15.76	13.58	31	29550	160187	64308964
Systemic lupus erythematosus	15.67	13.58	8	29573	77604	64391547
Impaired quality of life	15.64	13.58	17	29564	6454	64462697
Ventricular arrhythmia	15.40	13.58	18	29563	7397	64461754
Melaena	15.26	13.58	3	29578	53545	64415606
Platelet count decreased	15.19	13.58	34	29547	167677	64301474
Dyspepsia	15.19	13.58	75	29506	80237	64388914
Disease progression	15.19	13.58	26	29555	141654	64327497
Liver disorder	15.18	13.58	3	29578	53348	64415803
Mucosal inflammation	14.98	13.58	5	29576	62579	64406572
Hypoventilation	14.91	13.58	16	29565	5990	64463161
Stomatitis	14.86	13.58	17	29564	109588	64359563
Blood pressure increased	14.21	13.58	131	29450	172421	64296730
Anxiety	13.85	13.58	148	29433	202501	64266650
Wound	13.84	13.58	9	29572	76468	64392683

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N06AA10	NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Non-selective monoamine reuptake inhibitors
MeSH PA	D018663	Adrenergic Agents
MeSH PA	D018759	Adrenergic Uptake Inhibitors
MeSH PA	D000928	Antidepressive Agents
MeSH PA	D000929	Antidepressive Agents, Tricyclic
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D049990	Membrane Transport Modulators
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D014179	Neurotransmitter Uptake Inhibitors
MeSH PA	D011619	Psychotropic Drugs
CHEBI has role	CHEBI:35469	antidepressants
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:35640	adrenergic uptake inhibitors
CHEBI has role	CHEBI:49103	drug metabolites
CHEBI has role	CHEBI:68495	Type I cell-death inducers
CHEBI has role	CHEBI:176497	geroprotectors
FDA EPC	N0000175752	Tricyclic Antidepressant

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Depressive disorder	indication	35489007
Neuropathic pain	off-label use	247398009
Smoking cessation assistance	off-label use	384742004
Attention deficit hyperactivity disorder	off-label use	406506008
Suicidal thoughts	contraindication	6471006
Alcoholism	contraindication	7200002
Sinus tachycardia	contraindication	11092001
Lowered convulsive threshold	contraindication	19260006
Myocardial infarction	contraindication	22298006	DOID:5844
Glaucoma	contraindication	23986001	DOID:1686
Torsades de pointes	contraindication	31722008
Hyperthyroidism	contraindication	34486009	DOID:7998
Renal failure syndrome	contraindication	42399005	DOID:1074
Conduction disorder of the heart	contraindication	44808001
Hepatic failure	contraindication	59927004
Open-angle glaucoma	contraindication	84494001	DOID:1067
Epilepsy	contraindication	84757009	DOID:1826
Prolonged QT interval	contraindication	111975006
Seizure disorder	contraindication	128613002
Bipolar affective disorder, current episode manic	contraindication	191618007
Cerebrovascular accident	contraindication	230690007
Benign prostatic hyperplasia	contraindication	266569009
Retention of urine	contraindication	267064002
Non-Q wave myocardial infarction	contraindication	314207007
Breastfeeding (mother)	contraindication	413712001
Myocardial infarction in recovery phase	contraindication	418044006
Congenital long QT syndrome	contraindication	442917000

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.5	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN	INHIBITOR	Ki	7.34		WOMBAT-PK	CHEMBL
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN	INHIBITOR	Kd	8.36		WOMBAT-PK	CHEMBL
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	6.56		DRUG MATRIX
5-hydroxytryptamine receptor 1A	GPCR	P08908	5HT1A_HUMAN		Ki	6.51		WOMBAT-PK
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN		Ki	7.36		WOMBAT-PK
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	7.07		DRUG MATRIX
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	8		WOMBAT-PK
5-hydroxytryptamine receptor 6	GPCR	P50406	5HT6R_HUMAN		Ki	6.67		CHEMBL
Alpha-1A adrenergic receptor	GPCR	P35348	ADA1A_HUMAN		Ki	7.26		WOMBAT-PK
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	7		WOMBAT-PK
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	7.22		DRUG MATRIX
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN		Kd	8.03		WOMBAT-PK
Histamine H2 receptor	GPCR	P25021	HRH2_HUMAN		Ki	5.64		DRUG MATRIX
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN		Ki	7.40		WOMBAT-PK
Muscarinic acetylcholine receptor M2	GPCR	P08172	ACM2_HUMAN		Ki	6.96		WOMBAT-PK
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN		Ki	7.30		WOMBAT-PK
Muscarinic acetylcholine receptor M4	GPCR	P08173	ACM4_HUMAN		Ki	7.08		WOMBAT-PK
Muscarinic acetylcholine receptor M5	GPCR	P08912	ACM5_HUMAN		Ki	7.01		WOMBAT-PK
Aldehyde oxidase	Enzyme	Q06278	AOXA_HUMAN		IC50	6.07		WOMBAT-PK
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN		Ki	7.52		DRUG MATRIX
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN		Ki	5.92		PDSP
Cytochrome P450 2D6	Enzyme	P10635	CP2D6_HUMAN		Km	6.23		WOMBAT-PK
Alpha-1D adrenergic receptor	GPCR	P25100	ADA1D_HUMAN		Ki	6.91		DRUG MATRIX
Cytochrome P450 2C19	Enzyme	P33261	CP2CJ_HUMAN		IC50	5.52		DRUG MATRIX
Proto-oncogene tyrosine-protein kinase receptor Ret	Kinase	P07949	RET_HUMAN		IC50	5.82		CHEMBL
D(1A) dopamine receptor	GPCR	P21728	DRD1_HUMAN		Ki	6.57		DRUG MATRIX
ATP-sensitive inward rectifier potassium channel 10	Ion channel	P78508	KCJ10_HUMAN	BLOCKER	IC50	4.80		SCIENTIFIC LITERATURE
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN		Ki	5.59		PDSP
Alpha-1B adrenergic receptor	GPCR		ADA1B_RAT		Ki	6.94		DRUG MATRIX
5-hydroxytryptamine receptor 1B	GPCR		5HT1B_RAT		Ki	5.84		DRUG MATRIX
Alpha-1A adrenergic receptor	GPCR		ADA1A_RAT		IC50	10.40		CHEMBL
5-hydroxytryptamine receptor 1A	GPCR		5HT1A_RAT		IC50	5.73		CHEMBL
Histamine H1 receptor	GPCR		HRH1_RAT		IC50	10.30		CHEMBL

External reference:

ID	Source
4019860	VUID
N0000147946	NUI
D00816	KEGG_DRUG
894-71-3	SECONDARY_CAS_RN
4017520	VANDF
4019860	VANDF
C0028420	UMLSCUI
CHEBI:7640	CHEBI
21B	PDB_CHEM_ID
CHEMBL445	ChEMBL_ID
DB00540	DRUGBANK_ID
CHEMBL1201156	ChEMBL_ID
D009661	MESH_DESCRIPTOR_UI
4543	PUBCHEM_CID
2404	IUPHAR_LIGAND_ID
1328	INN_ID
BL03SY4LXB	UNII
203130	RXNORM
2733	MMSL
2740	MMSL
5192	MMSL
d00144	MMSL
001502	NDDF
004601	NDDF
13432000	SNOMEDCT_US
29666006	SNOMEDCT_US
372652004	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-0810	CAPSULE	10 mg	ORAL	ANDA	13 sections
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-0811	CAPSULE	25 mg	ORAL	ANDA	13 sections
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-0812	CAPSULE	50 mg	ORAL	ANDA	13 sections
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-0813	CAPSULE	75 mg	ORAL	ANDA	13 sections
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0121-0678	SOLUTION	10 mg	ORAL	ANDA	19 sections
PAMELOR	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9910	CAPSULE	10 mg	ORAL	NDA	19 sections
PAMELOR	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9911	CAPSULE	25 mg	ORAL	NDA	19 sections
PAMELOR	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9912	CAPSULE	50 mg	ORAL	NDA	19 sections
PAMELOR	HUMAN PRESCRIPTION DRUG LABEL	1	0406-9913	CAPSULE	75 mg	ORAL	NDA	19 sections
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	10544-567	CAPSULE	10 mg	ORAL	ANDA	18 sections
NORTRIPTYLINE HYDROCHLORIDE	HUMAN PRESCRIPTION DRUG LABEL	1	16590-171	CAPSULE	25 mg	ORAL	ANDA	16 sections
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	21695-093	CAPSULE	10 mg	ORAL	ANDA	13 sections
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	21695-094	CAPSULE	25 mg	ORAL	ANDA	13 sections
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	21695-599	CAPSULE	50 mg	ORAL	ANDA	13 sections
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	21695-600	CAPSULE	75 mg	ORAL	ANDA	13 sections
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	33261-348	CAPSULE	25 mg	ORAL	ANDA	18 sections
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	33261-532	CAPSULE	10 mg	ORAL	ANDA	18 sections
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	33261-692	CAPSULE	50 mg	ORAL	ANDA	18 sections
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	33261-804	CAPSULE	75 mg	ORAL	ANDA	18 sections
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	43063-722	CAPSULE	25 mg	ORAL	ANDA	18 sections
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	43063-897	CAPSULE	25 mg	ORAL	ANDA	19 sections
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	45865-371	CAPSULE	10 mg	ORAL	ANDA	18 sections
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	50090-0507	CAPSULE	25 mg	ORAL	ANDA	18 sections
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	50090-0537	CAPSULE	10 mg	ORAL	ANDA	18 sections
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	50090-1323	CAPSULE	50 mg	ORAL	ANDA	18 sections
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	50268-603	CAPSULE	10 mg	ORAL	ANDA	18 sections
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	50268-604	CAPSULE	25 mg	ORAL	ANDA	18 sections
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	50268-605	CAPSULE	50 mg	ORAL	ANDA	18 sections
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	50436-4022	CAPSULE	25 mg	ORAL	ANDA	17 sections
Nortriptyline Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	50436-6652	CAPSULE	10 mg	ORAL	ANDA	18 sections