Stem definition | Drug id | CAS RN |
---|---|---|
antidepressants, dibenzo[a,d]cycloheptane or cyclopheptene derivatives | 1971 | 72-69-5 |
Dose | Unit | Route |
---|---|---|
75 | mg | O |
30 | mg | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 2 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 6.34 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 51 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 22 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 10 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.12 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 30 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 6, 1964 | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Temperature regulation disorder | 414.74 | 13.80 | 133 | 26274 | 4094 | 50574623 |
Food allergy | 336.57 | 13.80 | 135 | 26272 | 8002 | 50570715 |
Coeliac disease | 328.06 | 13.80 | 135 | 26272 | 8550 | 50570167 |
Pneumonia aspiration | 317.23 | 13.80 | 199 | 26208 | 30805 | 50547912 |
Completed suicide | 286.30 | 13.80 | 348 | 26059 | 131541 | 50447176 |
Immunodeficiency | 267.66 | 13.80 | 138 | 26269 | 14690 | 50564027 |
Bursitis | 226.16 | 13.80 | 142 | 26265 | 21993 | 50556724 |
Coma | 202.29 | 13.80 | 195 | 26212 | 56684 | 50522033 |
Gastrooesophageal reflux disease | 184.31 | 13.80 | 213 | 26194 | 76215 | 50502502 |
Rash erythematous | 166.25 | 13.80 | 141 | 26266 | 34711 | 50544006 |
Toxicity to various agents | 160.81 | 13.80 | 347 | 26060 | 212152 | 50366565 |
Drug hypersensitivity | 156.91 | 13.80 | 380 | 26027 | 250630 | 50328087 |
Presbyacusis | 146.52 | 13.80 | 55 | 26352 | 2721 | 50575996 |
Asthma | 145.70 | 13.80 | 205 | 26202 | 89132 | 50489585 |
Pleural thickening | 142.68 | 13.80 | 53 | 26354 | 2546 | 50576171 |
Osteopenia | 141.55 | 13.80 | 96 | 26311 | 16922 | 50561795 |
Fluid retention | 140.64 | 13.80 | 152 | 26255 | 50497 | 50528220 |
Pleural fibrosis | 139.40 | 13.80 | 56 | 26351 | 3328 | 50575389 |
Somnolence | 138.26 | 13.80 | 271 | 26136 | 154714 | 50424003 |
Blood magnesium increased | 133.83 | 13.80 | 52 | 26355 | 2828 | 50575889 |
Deafness neurosensory | 133.61 | 13.80 | 59 | 26348 | 4442 | 50574275 |
Upper respiratory tract infection | 125.34 | 13.80 | 163 | 26244 | 65735 | 50512982 |
Hyperhidrosis | 110.00 | 13.80 | 180 | 26227 | 89246 | 50489471 |
Epigastric discomfort | 104.07 | 13.80 | 54 | 26353 | 5816 | 50572901 |
Neovascularisation | 99.85 | 13.80 | 32 | 26375 | 981 | 50577736 |
Bone cyst | 88.60 | 13.80 | 35 | 26372 | 1989 | 50576728 |
Rubber sensitivity | 81.71 | 13.80 | 32 | 26375 | 1777 | 50576940 |
Brugada syndrome | 80.06 | 13.80 | 21 | 26386 | 309 | 50578408 |
Cyst | 74.42 | 13.80 | 57 | 26350 | 12130 | 50566587 |
Back pain | 72.73 | 13.80 | 266 | 26141 | 219764 | 50358953 |
Paradoxical drug reaction | 65.94 | 13.80 | 34 | 26373 | 3613 | 50575104 |
Osteosclerosis | 64.65 | 13.80 | 33 | 26374 | 3434 | 50575283 |
Sensitivity to weather change | 60.01 | 13.80 | 38 | 26369 | 5963 | 50572754 |
Blood potassium increased | 59.69 | 13.80 | 57 | 26350 | 16341 | 50562376 |
Overdose | 58.90 | 13.80 | 148 | 26259 | 99579 | 50479138 |
Electrocardiogram QRS complex prolonged | 58.90 | 13.80 | 36 | 26371 | 5308 | 50573409 |
Hepatic enzyme increased | 58.55 | 13.80 | 181 | 26226 | 137199 | 50441518 |
Rheumatoid arthritis | 57.98 | 13.80 | 234 | 26173 | 202316 | 50376401 |
Constipation | 55.93 | 13.80 | 218 | 26189 | 185490 | 50393227 |
Poor venous access | 55.87 | 13.80 | 45 | 26362 | 10295 | 50568422 |
Hypersensitivity | 54.15 | 13.80 | 239 | 26168 | 214922 | 50363795 |
Erythema | 52.59 | 13.80 | 182 | 26225 | 146232 | 50432485 |
Forced expiratory volume decreased | 52.04 | 13.80 | 31 | 26376 | 4363 | 50574354 |
Traumatic coma | 51.51 | 13.80 | 11 | 26396 | 61 | 50578656 |
Migraine | 51.19 | 13.80 | 118 | 26289 | 75162 | 50503555 |
Skin lesion | 50.59 | 13.80 | 66 | 26341 | 26661 | 50552056 |
Somatic delusion | 48.18 | 13.80 | 16 | 26391 | 550 | 50578167 |
Sleep disorder | 47.16 | 13.80 | 97 | 26310 | 57186 | 50521531 |
Osteoarthritis | 46.05 | 13.80 | 107 | 26300 | 68499 | 50510218 |
Drug ineffective for unapproved indication | 45.75 | 13.80 | 56 | 26351 | 21225 | 50557492 |
Glossodynia | 42.92 | 13.80 | 5 | 26402 | 115564 | 50463153 |
Dry eye | 42.69 | 13.80 | 67 | 26340 | 32028 | 50546689 |
Deformity | 41.73 | 13.80 | 34 | 26373 | 7906 | 50570811 |
Polymyositis | 38.33 | 13.80 | 18 | 26389 | 1562 | 50577155 |
Systemic lupus erythematosus | 36.26 | 13.80 | 14 | 26393 | 140608 | 50438109 |
Neutropenia | 36.10 | 13.80 | 16 | 26391 | 147949 | 50430768 |
Bone density abnormal | 34.81 | 13.80 | 21 | 26386 | 3024 | 50575693 |
Suspected suicide | 34.79 | 13.80 | 26 | 26381 | 5331 | 50573386 |
Exposure during pregnancy | 34.77 | 13.80 | 10 | 26397 | 121005 | 50457712 |
Swelling | 33.78 | 13.80 | 33 | 26374 | 200839 | 50377878 |
Fatigue | 33.53 | 13.80 | 536 | 25871 | 707065 | 49871652 |
Alanine aminotransferase abnormal | 33.49 | 13.80 | 23 | 26384 | 4133 | 50574584 |
Anaemia | 33.43 | 13.80 | 50 | 26357 | 252406 | 50326311 |
Headache | 32.96 | 13.80 | 406 | 26001 | 506129 | 50072588 |
Unmasking of previously unidentified disease | 32.47 | 13.80 | 13 | 26394 | 765 | 50577952 |
Exostosis | 32.35 | 13.80 | 35 | 26372 | 11618 | 50567099 |
Maternal exposure during pregnancy | 32.14 | 13.80 | 22 | 26385 | 159756 | 50418961 |
Extrapyramidal disorder | 32.07 | 13.80 | 35 | 26372 | 11735 | 50566982 |
Wound | 31.80 | 13.80 | 8 | 26399 | 105786 | 50472931 |
Paranasal cyst | 31.79 | 13.80 | 10 | 26397 | 288 | 50578429 |
Vascular malformation | 31.63 | 13.80 | 10 | 26397 | 293 | 50578424 |
Spinal stenosis | 31.32 | 13.80 | 37 | 26370 | 13513 | 50565204 |
Femoral neck fracture | 31.05 | 13.80 | 28 | 26379 | 7462 | 50571255 |
Pancytopenia | 30.30 | 13.80 | 4 | 26403 | 84026 | 50494691 |
Occult blood | 30.05 | 13.80 | 14 | 26393 | 1193 | 50577524 |
Cardiac arrest | 29.14 | 13.80 | 103 | 26304 | 83548 | 50495169 |
Unresponsive to stimuli | 29.01 | 13.80 | 55 | 26352 | 30554 | 50548163 |
Anuria | 28.16 | 13.80 | 32 | 26375 | 11212 | 50567505 |
Pericarditis | 27.77 | 13.80 | 4 | 26403 | 78685 | 50500032 |
Acute kidney injury | 27.52 | 13.80 | 48 | 26359 | 228010 | 50350707 |
Lower respiratory tract infection | 27.10 | 13.80 | 8 | 26399 | 95193 | 50483524 |
Blood pressure abnormal | 26.52 | 13.80 | 33 | 26374 | 12714 | 50566003 |
Febrile neutropenia | 26.39 | 13.80 | 9 | 26398 | 97658 | 50481059 |
Carpal tunnel syndrome | 26.35 | 13.80 | 38 | 26369 | 16855 | 50561862 |
Accidental death | 25.18 | 13.80 | 14 | 26393 | 1730 | 50576987 |
Mastoiditis | 24.92 | 13.80 | 11 | 26396 | 827 | 50577890 |
Systolic dysfunction | 24.55 | 13.80 | 13 | 26394 | 1459 | 50577258 |
Ventricular tachyarrhythmia | 23.85 | 13.80 | 6 | 26401 | 74 | 50578643 |
Suicidal ideation | 23.58 | 13.80 | 73 | 26334 | 55312 | 50523405 |
Failed induction of labour | 23.25 | 13.80 | 8 | 26399 | 307 | 50578410 |
Electrocardiogram ST segment elevation | 22.87 | 13.80 | 17 | 26390 | 3456 | 50575261 |
Leukopenia | 22.55 | 13.80 | 4 | 26403 | 67524 | 50511193 |
Vomiting | 21.28 | 13.80 | 147 | 26260 | 460611 | 50118106 |
Electrocardiogram repolarisation abnormality | 21.15 | 13.80 | 11 | 26396 | 1189 | 50577528 |
Alopecia | 21.07 | 13.80 | 62 | 26345 | 244985 | 50333732 |
Delirium | 20.79 | 13.80 | 55 | 26352 | 38137 | 50540580 |
Cardiac failure | 20.56 | 13.80 | 7 | 26400 | 76033 | 50502684 |
Hyperaesthesia | 20.03 | 13.80 | 23 | 26384 | 8150 | 50570567 |
Treatment failure | 19.02 | 13.80 | 130 | 26277 | 137507 | 50441210 |
Gastrointestinal motility disorder | 18.98 | 13.80 | 17 | 26390 | 4492 | 50574225 |
Hypoventilation | 18.96 | 13.80 | 16 | 26391 | 3905 | 50574812 |
Fibromyalgia | 18.88 | 13.80 | 59 | 26348 | 44919 | 50533798 |
Oral discomfort | 18.71 | 13.80 | 22 | 26385 | 7995 | 50570722 |
Renal failure | 18.51 | 13.80 | 17 | 26390 | 106616 | 50472101 |
Postmortem blood drug level increased | 18.47 | 13.80 | 8 | 26399 | 574 | 50578143 |
Long QT syndrome | 18.38 | 13.80 | 14 | 26393 | 2953 | 50575764 |
Disease progression | 18.22 | 13.80 | 14 | 26393 | 95852 | 50482865 |
Pyrexia | 18.18 | 13.80 | 120 | 26287 | 380083 | 50198634 |
Essential tremor | 18.13 | 13.80 | 9 | 26398 | 882 | 50577835 |
Antidepressant drug level above therapeutic | 18.09 | 13.80 | 7 | 26400 | 376 | 50578341 |
Abnormal faeces | 18.02 | 13.80 | 16 | 26391 | 4180 | 50574537 |
Sepsis | 17.89 | 13.80 | 26 | 26381 | 132899 | 50445818 |
Malignant neoplasm progression | 17.19 | 13.80 | 7 | 26400 | 68117 | 50510600 |
Rash | 17.15 | 13.80 | 146 | 26261 | 437325 | 50141392 |
Allodynia | 17.15 | 13.80 | 8 | 26399 | 684 | 50578033 |
Urine odour abnormal | 16.45 | 13.80 | 17 | 26390 | 5356 | 50573361 |
Blood pressure increased | 16.22 | 13.80 | 122 | 26285 | 133010 | 50445707 |
Threatened labour | 16.17 | 13.80 | 8 | 26399 | 779 | 50577938 |
Dry mouth | 16.10 | 13.80 | 65 | 26342 | 56113 | 50522604 |
Pleural rub | 16 | 13.80 | 4 | 26403 | 48 | 50578669 |
Stomatitis | 15.51 | 13.80 | 18 | 26389 | 101326 | 50477391 |
Noninfectious myelitis | 15.28 | 13.80 | 3 | 26404 | 10 | 50578707 |
Heart rate increased | 15.17 | 13.80 | 80 | 26327 | 77170 | 50501547 |
Immune thrombocytopenia | 15.12 | 13.80 | 21 | 26386 | 8996 | 50569721 |
Respiratory arrest | 15.11 | 13.80 | 42 | 26365 | 29967 | 50548750 |
Bone hypertrophy | 14.80 | 13.80 | 6 | 26401 | 365 | 50578352 |
Asthenia | 14.59 | 13.80 | 102 | 26305 | 318940 | 50259777 |
Pain | 14.57 | 13.80 | 400 | 26007 | 578503 | 50000214 |
Procedural pain | 14.54 | 13.80 | 26 | 26381 | 13806 | 50564911 |
Adverse reaction | 14.41 | 13.80 | 20 | 26387 | 8566 | 50570151 |
Blister | 14.38 | 13.80 | 14 | 26393 | 85404 | 50493313 |
Acute lung injury | 14.37 | 13.80 | 9 | 26398 | 1384 | 50577333 |
Abdominal discomfort | 13.81 | 13.80 | 68 | 26339 | 231573 | 50347144 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Toxicity to various agents | 296.24 | 17.07 | 285 | 7183 | 173376 | 29393683 |
Completed suicide | 162.27 | 17.07 | 153 | 7315 | 90093 | 29476966 |
Sedation | 154.00 | 17.07 | 79 | 7389 | 17326 | 29549733 |
Suicidal ideation | 90.77 | 17.07 | 73 | 7395 | 34643 | 29532416 |
Myokymia | 88.60 | 17.07 | 16 | 7452 | 76 | 29566983 |
Nightmare | 68.18 | 17.07 | 40 | 7428 | 11377 | 29555682 |
Nephrolithiasis | 51.25 | 17.07 | 46 | 7422 | 25288 | 29541771 |
Drug abuse | 50.63 | 17.07 | 80 | 7388 | 79803 | 29487256 |
Electrocardiogram QRS complex prolonged | 46.25 | 17.07 | 22 | 7446 | 4088 | 29562971 |
Brugada syndrome | 38.78 | 17.07 | 12 | 7456 | 689 | 29566370 |
Hyperhidrosis | 33.33 | 17.07 | 59 | 7409 | 64481 | 29502578 |
Drug hypersensitivity | 32.11 | 17.07 | 60 | 7408 | 68346 | 29498713 |
Serotonin syndrome | 28.14 | 17.07 | 28 | 7440 | 17484 | 29549575 |
Obsessive-compulsive disorder | 27.22 | 17.07 | 16 | 7452 | 4560 | 29562499 |
Overdose | 26.82 | 17.07 | 61 | 7407 | 79758 | 29487301 |
Impaired quality of life | 26.39 | 17.07 | 13 | 7455 | 2606 | 29564453 |
Respiratory depression | 26.24 | 17.07 | 24 | 7444 | 13499 | 29553560 |
Reversible airways obstruction | 26.00 | 17.07 | 7 | 7461 | 244 | 29566815 |
Feelings of worthlessness | 25.57 | 17.07 | 7 | 7461 | 260 | 29566799 |
Depression | 25.27 | 17.07 | 62 | 7406 | 85085 | 29481974 |
Binocular eye movement disorder | 24.10 | 17.07 | 5 | 7463 | 54 | 29567005 |
Substance abuse | 21.47 | 17.07 | 16 | 7452 | 6771 | 29560288 |
Fall | 21.45 | 17.07 | 95 | 7373 | 177083 | 29389976 |
Abulia | 21.09 | 17.07 | 7 | 7461 | 504 | 29566555 |
Anaemia | 20.14 | 17.07 | 13 | 7455 | 200938 | 29366121 |
Suicide attempt | 19.98 | 17.07 | 33 | 7435 | 34077 | 29532982 |
Decreased interest | 19.74 | 17.07 | 10 | 7458 | 2128 | 29564931 |
Ventricular arrhythmia | 19.56 | 17.07 | 13 | 7455 | 4591 | 29562468 |
Drug ineffective | 19.41 | 17.07 | 157 | 7311 | 363013 | 29204046 |
Product used for unknown indication | 19.20 | 17.07 | 6 | 7462 | 356 | 29566703 |
Major depression | 19.18 | 17.07 | 12 | 7456 | 3823 | 29563236 |
Pyrexia | 19.05 | 17.07 | 27 | 7441 | 287595 | 29279464 |
Benzodiazepine drug level therapeutic | 18.89 | 17.07 | 4 | 7464 | 48 | 29567011 |
Nausea | 18.80 | 17.07 | 131 | 7337 | 289124 | 29277935 |
Suspected suicide | 18.66 | 17.07 | 12 | 7456 | 4008 | 29563051 |
Vertigo | 18.31 | 17.07 | 25 | 7443 | 21836 | 29545223 |
Action tremor | 18.19 | 17.07 | 4 | 7464 | 58 | 29567001 |
Inadequate analgesia | 17.70 | 17.07 | 10 | 7458 | 2644 | 29564415 |
Cardio-respiratory arrest | 17.34 | 17.07 | 39 | 7429 | 50562 | 29516497 |
Postmortem blood drug level increased | 17.32 | 17.07 | 5 | 7463 | 226 | 29566833 |
Myoclonus | 17.29 | 17.07 | 19 | 7449 | 13290 | 29553769 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 434.76 | 13.58 | 524 | 29057 | 223890 | 64245261 |
Temperature regulation disorder | 423.64 | 13.58 | 131 | 29450 | 4080 | 64465071 |
Toxicity to various agents | 367.21 | 13.58 | 622 | 28959 | 362891 | 64106260 |
Food allergy | 350.91 | 13.58 | 133 | 29448 | 7718 | 64461433 |
Coeliac disease | 347.38 | 13.58 | 130 | 29451 | 7282 | 64461869 |
Immunodeficiency | 267.69 | 13.58 | 136 | 29445 | 15988 | 64453163 |
Bursitis | 239.02 | 13.58 | 139 | 29442 | 21346 | 64447805 |
Pneumonia aspiration | 210.98 | 13.58 | 192 | 29389 | 59079 | 64410072 |
Drug hypersensitivity | 202.12 | 13.58 | 378 | 29203 | 237437 | 64231714 |
Gastrooesophageal reflux disease | 156.89 | 13.58 | 192 | 29389 | 82951 | 64386200 |
Coma | 145.75 | 13.58 | 190 | 29391 | 87425 | 64381726 |
Presbyacusis | 142.26 | 13.58 | 51 | 29530 | 2524 | 64466627 |
Rash erythematous | 139.70 | 13.58 | 140 | 29441 | 48493 | 64420658 |
Asthma | 139.34 | 13.58 | 194 | 29387 | 95031 | 64374120 |
Osteopenia | 130.45 | 13.58 | 84 | 29497 | 15456 | 64453695 |
Fluid retention | 129.55 | 13.58 | 148 | 29433 | 59458 | 64409693 |
Pleural thickening | 128.66 | 13.58 | 48 | 29533 | 2662 | 64466489 |
Hyperhidrosis | 124.40 | 13.58 | 213 | 29368 | 124707 | 64344444 |
Upper respiratory tract infection | 122.83 | 13.58 | 159 | 29422 | 72626 | 64396525 |
Pleural fibrosis | 119.84 | 13.58 | 51 | 29530 | 3999 | 64465152 |
Somnolence | 118.11 | 13.58 | 277 | 29304 | 203368 | 64265783 |
Blood magnesium increased | 116.99 | 13.58 | 47 | 29534 | 3184 | 64465967 |
Deafness neurosensory | 109.37 | 13.58 | 55 | 29526 | 6319 | 64462832 |
Brugada syndrome | 106.14 | 13.58 | 33 | 29548 | 1045 | 64468106 |
Neovascularisation | 101.23 | 13.58 | 32 | 29549 | 1071 | 64468080 |
Rubber sensitivity | 95.30 | 13.58 | 32 | 29549 | 1300 | 64467851 |
Electrocardiogram QRS complex prolonged | 92.82 | 13.58 | 56 | 29525 | 9188 | 64459963 |
Rheumatoid arthritis | 92.51 | 13.58 | 221 | 29360 | 164073 | 64305078 |
Bone cyst | 90.20 | 13.58 | 35 | 29546 | 2162 | 64466989 |
Epigastric discomfort | 86.30 | 13.58 | 48 | 29533 | 6763 | 64462388 |
Overdose | 77.58 | 13.58 | 203 | 29378 | 159363 | 64309788 |
Myokymia | 75.09 | 13.58 | 16 | 29565 | 102 | 64469049 |
Back pain | 74.49 | 13.58 | 268 | 29313 | 249903 | 64219248 |
Hepatic enzyme increased | 74.42 | 13.58 | 176 | 29405 | 129767 | 64339384 |
Hypersensitivity | 74.11 | 13.58 | 228 | 29353 | 196224 | 64272927 |
Osteosclerosis | 68.52 | 13.58 | 33 | 29548 | 3453 | 64465698 |
Cyst | 67.98 | 13.58 | 51 | 29530 | 11976 | 64457175 |
Migraine | 62.48 | 13.58 | 107 | 29474 | 62570 | 64406581 |
Anaemia | 61.68 | 13.58 | 50 | 29531 | 378630 | 64090521 |
Sedation | 61.37 | 13.58 | 85 | 29496 | 41377 | 64427774 |
Sensitivity to weather change | 58.09 | 13.58 | 37 | 29544 | 6677 | 64462474 |
Poor venous access | 55.82 | 13.58 | 46 | 29535 | 12371 | 64456780 |
Febrile neutropenia | 54.64 | 13.58 | 10 | 29571 | 187647 | 64281504 |
Neutropenia | 52.64 | 13.58 | 22 | 29559 | 239602 | 64229549 |
Sleep disorder | 51.88 | 13.58 | 96 | 29485 | 59613 | 64409538 |
Constipation | 50.76 | 13.58 | 224 | 29357 | 229113 | 64240038 |
Deformity | 50.29 | 13.58 | 33 | 29548 | 6264 | 64462887 |
Traumatic coma | 48.98 | 13.58 | 10 | 29571 | 50 | 64469101 |
Paradoxical drug reaction | 48.70 | 13.58 | 32 | 29549 | 6088 | 64463063 |
Drug ineffective for unapproved indication | 47.84 | 13.58 | 65 | 29516 | 31068 | 64438083 |
Somatic delusion | 47.09 | 13.58 | 16 | 29565 | 674 | 64468477 |
Forced expiratory volume decreased | 45.36 | 13.58 | 32 | 29549 | 6835 | 64462316 |
Osteoarthritis | 44.34 | 13.58 | 93 | 29488 | 63243 | 64405908 |
Acute kidney injury | 42.56 | 13.58 | 89 | 29492 | 449151 | 64020000 |
Pain | 39.86 | 13.58 | 408 | 29173 | 553103 | 63916048 |
Fatigue | 39.71 | 13.58 | 520 | 29061 | 748210 | 63720941 |
Blood potassium increased | 39.55 | 13.58 | 54 | 29527 | 25926 | 64443225 |
Erythema | 39.32 | 13.58 | 180 | 29401 | 186890 | 64282261 |
Dry eye | 39.25 | 13.58 | 57 | 29524 | 28962 | 64440189 |
Pancytopenia | 38.89 | 13.58 | 9 | 29572 | 143300 | 64325851 |
Suspected suicide | 38.77 | 13.58 | 32 | 29549 | 8622 | 64460529 |
Treatment failure | 38.03 | 13.58 | 129 | 29452 | 116687 | 64352464 |
Pyrexia | 37.60 | 13.58 | 131 | 29450 | 558513 | 63910638 |
Headache | 37.02 | 13.58 | 388 | 29193 | 529079 | 63940072 |
Exostosis | 36.69 | 13.58 | 35 | 29546 | 11403 | 64457748 |
Bone density abnormal | 36.57 | 13.58 | 20 | 29561 | 2725 | 64466426 |
Drug abuse | 36.13 | 13.58 | 138 | 29443 | 132236 | 64336915 |
Skin lesion | 35.98 | 13.58 | 62 | 29519 | 36420 | 64432731 |
Leukopenia | 35.25 | 13.58 | 3 | 29578 | 101239 | 64367912 |
Suicidal ideation | 34.71 | 13.58 | 87 | 29494 | 66455 | 64402696 |
Vascular malformation | 32.93 | 13.58 | 10 | 29571 | 292 | 64468859 |
Thrombocytopenia | 32.28 | 13.58 | 33 | 29548 | 223768 | 64245383 |
Paranasal cyst | 31.65 | 13.58 | 10 | 29571 | 334 | 64468817 |
Respiratory depression | 31.64 | 13.58 | 46 | 29535 | 23397 | 64445754 |
Polymyositis | 31.36 | 13.58 | 18 | 29563 | 2692 | 64466459 |
Occult blood | 29.78 | 13.58 | 14 | 29567 | 1388 | 64467763 |
Cardiac failure | 29.30 | 13.58 | 12 | 29569 | 132361 | 64336790 |
Spinal stenosis | 29.24 | 13.58 | 34 | 29547 | 13897 | 64455254 |
Carpal tunnel syndrome | 28.92 | 13.58 | 36 | 29545 | 15792 | 64453359 |
Femoral neck fracture | 28.56 | 13.58 | 27 | 29554 | 8697 | 64460454 |
Unresponsive to stimuli | 27.46 | 13.58 | 67 | 29514 | 50326 | 64418825 |
Extrapyramidal disorder | 27.31 | 13.58 | 39 | 29542 | 19513 | 64449638 |
Nightmare | 25.20 | 13.58 | 39 | 29542 | 20954 | 64448197 |
Abnormal faeces | 24.87 | 13.58 | 21 | 29560 | 5838 | 64463313 |
Renal failure | 24.84 | 13.58 | 28 | 29553 | 181660 | 64287491 |
Unmasking of previously unidentified disease | 24.75 | 13.58 | 13 | 29568 | 1634 | 64467517 |
Delirium | 23.92 | 13.58 | 78 | 29503 | 69116 | 64400035 |
Alanine aminotransferase abnormal | 23.86 | 13.58 | 22 | 29559 | 6866 | 64462285 |
Accidental death | 23.77 | 13.58 | 17 | 29564 | 3708 | 64465443 |
Substance abuse | 23.50 | 13.58 | 25 | 29556 | 9267 | 64459884 |
Blood pressure abnormal | 23.49 | 13.58 | 31 | 29550 | 14404 | 64454747 |
Major depression | 23.34 | 13.58 | 23 | 29558 | 7793 | 64461358 |
Sepsis | 23.17 | 13.58 | 44 | 29537 | 230297 | 64238854 |
Hyperkalaemia | 22.65 | 13.58 | 9 | 29572 | 101120 | 64368031 |
Failed induction of labour | 22.12 | 13.58 | 7 | 29574 | 235 | 64468916 |
Dry mouth | 21.69 | 13.58 | 69 | 29512 | 60349 | 64408802 |
Pneumonia | 21.68 | 13.58 | 159 | 29422 | 559417 | 63909734 |
Atrial fibrillation | 21.66 | 13.58 | 28 | 29553 | 171061 | 64298090 |
Intentional overdose | 21.50 | 13.58 | 90 | 29491 | 89854 | 64379297 |
Contraindicated product administered | 21.34 | 13.58 | 102 | 29479 | 107727 | 64361424 |
Cardio-respiratory arrest | 20.89 | 13.58 | 95 | 29486 | 98298 | 64370853 |
Exposure during pregnancy | 20.82 | 13.58 | 5 | 29576 | 77670 | 64391481 |
Postmortem blood drug level increased | 20.60 | 13.58 | 9 | 29572 | 752 | 64468399 |
Mastoiditis | 20.57 | 13.58 | 11 | 29570 | 1434 | 64467717 |
Oral discomfort | 20.18 | 13.58 | 22 | 29559 | 8384 | 64460767 |
Obsessive-compulsive disorder | 19.90 | 13.58 | 17 | 29564 | 4801 | 64464350 |
General physical health deterioration | 19.73 | 13.58 | 40 | 29541 | 204385 | 64264766 |
Multiple organ dysfunction syndrome | 19.67 | 13.58 | 11 | 29570 | 101402 | 64367749 |
International normalised ratio increased | 19.52 | 13.58 | 6 | 29575 | 79161 | 64389990 |
Malignant neoplasm progression | 19.48 | 13.58 | 14 | 29567 | 112857 | 64356294 |
Alanine aminotransferase increased | 19.47 | 13.58 | 21 | 29560 | 139010 | 64330141 |
Respiratory arrest | 19.47 | 13.58 | 61 | 29520 | 52924 | 64416227 |
Vomiting | 19.29 | 13.58 | 161 | 29420 | 550956 | 63918195 |
Aspartate aminotransferase increased | 19.23 | 13.58 | 16 | 29565 | 119772 | 64349379 |
Urine odour abnormal | 18.96 | 13.58 | 17 | 29564 | 5119 | 64464032 |
Fibromyalgia | 18.92 | 13.58 | 47 | 29534 | 35684 | 64433467 |
Gastrointestinal motility disorder | 18.84 | 13.58 | 17 | 29564 | 5162 | 64463989 |
Lower respiratory tract infection | 18.74 | 13.58 | 10 | 29571 | 94604 | 64374547 |
Ascites | 18.70 | 13.58 | 3 | 29578 | 61998 | 64407153 |
Hyperaesthesia | 18.65 | 13.58 | 23 | 29558 | 9991 | 64459160 |
Nephrolithiasis | 18.61 | 13.58 | 53 | 29528 | 43630 | 64425521 |
Heart rate increased | 18.56 | 13.58 | 92 | 29489 | 98583 | 64370568 |
Anuria | 18.39 | 13.58 | 32 | 29549 | 18932 | 64450219 |
Adverse reaction | 18.24 | 13.58 | 20 | 29561 | 7667 | 64461484 |
Cardiac arrest | 18.18 | 13.58 | 127 | 29454 | 153937 | 64315214 |
Binocular eye movement disorder | 18.12 | 13.58 | 5 | 29576 | 103 | 64469048 |
Electrocardiogram repolarisation abnormality | 17.86 | 13.58 | 11 | 29570 | 1871 | 64467280 |
Ventricular tachyarrhythmia | 17.68 | 13.58 | 6 | 29575 | 252 | 64468899 |
Decreased appetite | 17.53 | 13.58 | 68 | 29513 | 281221 | 64187930 |
Electrocardiogram ST segment elevation | 17.43 | 13.58 | 19 | 29562 | 7240 | 64461911 |
Feelings of worthlessness | 17.35 | 13.58 | 7 | 29574 | 479 | 64468672 |
Oedema peripheral | 17.19 | 13.58 | 45 | 29536 | 210272 | 64258879 |
Reversible airways obstruction | 17.15 | 13.58 | 9 | 29572 | 1129 | 64468022 |
Pleural rub | 16.92 | 13.58 | 4 | 29577 | 43 | 64469108 |
Pericarditis | 16.80 | 13.58 | 4 | 29577 | 62512 | 64406639 |
Prescribed overdose | 16.79 | 13.58 | 32 | 29549 | 20299 | 64448852 |
Pleural effusion | 16.76 | 13.58 | 20 | 29561 | 126539 | 64342612 |
Multiple sclerosis relapse | 16.65 | 13.58 | 49 | 29532 | 41086 | 64428065 |
Benzodiazepine drug level therapeutic | 16.51 | 13.58 | 4 | 29577 | 48 | 64469103 |
Lactic acidosis | 16.37 | 13.58 | 4 | 29577 | 61406 | 64407745 |
Threatened labour | 16.33 | 13.58 | 7 | 29574 | 558 | 64468593 |
Bone hypertrophy | 16.30 | 13.58 | 6 | 29575 | 320 | 64468831 |
Drug ineffective | 16.07 | 13.58 | 501 | 29080 | 839746 | 63629405 |
Hepatic failure | 16.01 | 13.58 | 3 | 29578 | 55391 | 64413760 |
Essential tremor | 15.91 | 13.58 | 9 | 29572 | 1310 | 64467841 |
Septic shock | 15.82 | 13.58 | 15 | 29566 | 105422 | 64363729 |
Swelling | 15.76 | 13.58 | 31 | 29550 | 160187 | 64308964 |
Systemic lupus erythematosus | 15.67 | 13.58 | 8 | 29573 | 77604 | 64391547 |
Impaired quality of life | 15.64 | 13.58 | 17 | 29564 | 6454 | 64462697 |
Ventricular arrhythmia | 15.40 | 13.58 | 18 | 29563 | 7397 | 64461754 |
Melaena | 15.26 | 13.58 | 3 | 29578 | 53545 | 64415606 |
Platelet count decreased | 15.19 | 13.58 | 34 | 29547 | 167677 | 64301474 |
Dyspepsia | 15.19 | 13.58 | 75 | 29506 | 80237 | 64388914 |
Disease progression | 15.19 | 13.58 | 26 | 29555 | 141654 | 64327497 |
Liver disorder | 15.18 | 13.58 | 3 | 29578 | 53348 | 64415803 |
Mucosal inflammation | 14.98 | 13.58 | 5 | 29576 | 62579 | 64406572 |
Hypoventilation | 14.91 | 13.58 | 16 | 29565 | 5990 | 64463161 |
Stomatitis | 14.86 | 13.58 | 17 | 29564 | 109588 | 64359563 |
Blood pressure increased | 14.21 | 13.58 | 131 | 29450 | 172421 | 64296730 |
Anxiety | 13.85 | 13.58 | 148 | 29433 | 202501 | 64266650 |
Wound | 13.84 | 13.58 | 9 | 29572 | 76468 | 64392683 |
None
Source | Code | Description |
---|---|---|
ATC | N06AA10 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Non-selective monoamine reuptake inhibitors |
MeSH PA | D018663 | Adrenergic Agents |
MeSH PA | D018759 | Adrenergic Uptake Inhibitors |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D000929 | Antidepressive Agents, Tricyclic |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
MeSH PA | D011619 | Psychotropic Drugs |
CHEBI has role | CHEBI:35469 | antidepressants |
CHEBI has role | CHEBI:35610 | antineoplastic agents |
CHEBI has role | CHEBI:35640 | adrenergic uptake inhibitors |
CHEBI has role | CHEBI:49103 | drug metabolites |
CHEBI has role | CHEBI:68495 | Type I cell-death inducers |
CHEBI has role | CHEBI:176497 | geroprotectors |
FDA EPC | N0000175752 | Tricyclic Antidepressant |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Depressive disorder | indication | 35489007 | |
Neuropathic pain | off-label use | 247398009 | |
Smoking cessation assistance | off-label use | 384742004 | |
Attention deficit hyperactivity disorder | off-label use | 406506008 | |
Suicidal thoughts | contraindication | 6471006 | |
Alcoholism | contraindication | 7200002 | |
Sinus tachycardia | contraindication | 11092001 | |
Lowered convulsive threshold | contraindication | 19260006 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Torsades de pointes | contraindication | 31722008 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Renal failure syndrome | contraindication | 42399005 | DOID:1074 |
Conduction disorder of the heart | contraindication | 44808001 | |
Hepatic failure | contraindication | 59927004 | |
Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Prolonged QT interval | contraindication | 111975006 | |
Seizure disorder | contraindication | 128613002 | |
Bipolar affective disorder, current episode manic | contraindication | 191618007 | |
Cerebrovascular accident | contraindication | 230690007 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Non-Q wave myocardial infarction | contraindication | 314207007 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Myocardial infarction in recovery phase | contraindication | 418044006 | |
Congenital long QT syndrome | contraindication | 442917000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.5 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter | Transporter | INHIBITOR | Ki | 7.34 | WOMBAT-PK | CHEMBL | |||
Sodium-dependent noradrenaline transporter | Transporter | INHIBITOR | Kd | 8.36 | WOMBAT-PK | CHEMBL | |||
Alpha-2A adrenergic receptor | GPCR | Ki | 6.56 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 1A | GPCR | Ki | 6.51 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 7.36 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 7.07 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 8 | WOMBAT-PK | |||||
5-hydroxytryptamine receptor 6 | GPCR | Ki | 6.67 | CHEMBL | |||||
Alpha-1A adrenergic receptor | GPCR | Ki | 7.26 | WOMBAT-PK | |||||
Alpha-2B adrenergic receptor | GPCR | Ki | 7 | WOMBAT-PK | |||||
D(3) dopamine receptor | GPCR | Ki | 7.22 | DRUG MATRIX | |||||
Histamine H1 receptor | GPCR | Kd | 8.03 | WOMBAT-PK | |||||
Histamine H2 receptor | GPCR | Ki | 5.64 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 7.40 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M2 | GPCR | Ki | 6.96 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M3 | GPCR | Ki | 7.30 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M4 | GPCR | Ki | 7.08 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M5 | GPCR | Ki | 7.01 | WOMBAT-PK | |||||
Aldehyde oxidase | Enzyme | IC50 | 6.07 | WOMBAT-PK | |||||
Alpha-2C adrenergic receptor | GPCR | Ki | 7.52 | DRUG MATRIX | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 5.92 | PDSP | |||||
Cytochrome P450 2D6 | Enzyme | Km | 6.23 | WOMBAT-PK | |||||
Alpha-1D adrenergic receptor | GPCR | Ki | 6.91 | DRUG MATRIX | |||||
Cytochrome P450 2C19 | Enzyme | IC50 | 5.52 | DRUG MATRIX | |||||
Proto-oncogene tyrosine-protein kinase receptor Ret | Kinase | IC50 | 5.82 | CHEMBL | |||||
D(1A) dopamine receptor | GPCR | Ki | 6.57 | DRUG MATRIX | |||||
ATP-sensitive inward rectifier potassium channel 10 | Ion channel | BLOCKER | IC50 | 4.80 | SCIENTIFIC LITERATURE | ||||
D(2) dopamine receptor | GPCR | Ki | 5.59 | PDSP | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 6.94 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 1B | GPCR | Ki | 5.84 | DRUG MATRIX | |||||
Alpha-1A adrenergic receptor | GPCR | IC50 | 10.40 | CHEMBL | |||||
5-hydroxytryptamine receptor 1A | GPCR | IC50 | 5.73 | CHEMBL | |||||
Histamine H1 receptor | GPCR | IC50 | 10.30 | CHEMBL |
ID | Source |
---|---|
4019860 | VUID |
N0000147946 | NUI |
D00816 | KEGG_DRUG |
894-71-3 | SECONDARY_CAS_RN |
4017520 | VANDF |
4019860 | VANDF |
C0028420 | UMLSCUI |
CHEBI:7640 | CHEBI |
21B | PDB_CHEM_ID |
CHEMBL445 | ChEMBL_ID |
DB00540 | DRUGBANK_ID |
CHEMBL1201156 | ChEMBL_ID |
D009661 | MESH_DESCRIPTOR_UI |
4543 | PUBCHEM_CID |
2404 | IUPHAR_LIGAND_ID |
1328 | INN_ID |
BL03SY4LXB | UNII |
203130 | RXNORM |
2733 | MMSL |
2740 | MMSL |
5192 | MMSL |
d00144 | MMSL |
001502 | NDDF |
004601 | NDDF |
13432000 | SNOMEDCT_US |
29666006 | SNOMEDCT_US |
372652004 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0810 | CAPSULE | 10 mg | ORAL | ANDA | 13 sections |
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0811 | CAPSULE | 25 mg | ORAL | ANDA | 13 sections |
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0812 | CAPSULE | 50 mg | ORAL | ANDA | 13 sections |
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-0813 | CAPSULE | 75 mg | ORAL | ANDA | 13 sections |
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0678 | SOLUTION | 10 mg | ORAL | ANDA | 19 sections |
PAMELOR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0406-9910 | CAPSULE | 10 mg | ORAL | NDA | 19 sections |
PAMELOR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0406-9911 | CAPSULE | 25 mg | ORAL | NDA | 19 sections |
PAMELOR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0406-9912 | CAPSULE | 50 mg | ORAL | NDA | 19 sections |
PAMELOR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0406-9913 | CAPSULE | 75 mg | ORAL | NDA | 19 sections |
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10544-567 | CAPSULE | 10 mg | ORAL | ANDA | 18 sections |
NORTRIPTYLINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-171 | CAPSULE | 25 mg | ORAL | ANDA | 16 sections |
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-093 | CAPSULE | 10 mg | ORAL | ANDA | 13 sections |
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-094 | CAPSULE | 25 mg | ORAL | ANDA | 13 sections |
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-599 | CAPSULE | 50 mg | ORAL | ANDA | 13 sections |
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-600 | CAPSULE | 75 mg | ORAL | ANDA | 13 sections |
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-348 | CAPSULE | 25 mg | ORAL | ANDA | 18 sections |
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-532 | CAPSULE | 10 mg | ORAL | ANDA | 18 sections |
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-692 | CAPSULE | 50 mg | ORAL | ANDA | 18 sections |
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-804 | CAPSULE | 75 mg | ORAL | ANDA | 18 sections |
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-722 | CAPSULE | 25 mg | ORAL | ANDA | 18 sections |
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-897 | CAPSULE | 25 mg | ORAL | ANDA | 19 sections |
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45865-371 | CAPSULE | 10 mg | ORAL | ANDA | 18 sections |
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0507 | CAPSULE | 25 mg | ORAL | ANDA | 18 sections |
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0537 | CAPSULE | 10 mg | ORAL | ANDA | 18 sections |
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-1323 | CAPSULE | 50 mg | ORAL | ANDA | 18 sections |
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50268-603 | CAPSULE | 10 mg | ORAL | ANDA | 18 sections |
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50268-604 | CAPSULE | 25 mg | ORAL | ANDA | 18 sections |
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50268-605 | CAPSULE | 50 mg | ORAL | ANDA | 18 sections |
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50436-4022 | CAPSULE | 25 mg | ORAL | ANDA | 17 sections |
Nortriptyline Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50436-6652 | CAPSULE | 10 mg | ORAL | ANDA | 18 sections |