norepinephrine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sympathomimetic, phenethyl derivatives 1960 51-41-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • norepinephrine
  • (R)-Norepinephrine
  • arterenol
  • levarterenol
  • noradrenaline
  • norepinephrine bitartrate
  • (-)-noradrenaline
Precursor of epinephrine that is secreted by the ADRENAL MEDULLA and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers, and of the diffuse projection system in the brain that arises from the LOCUS CERULEUS. It is also found in plants and is used pharmacologically as a sympathomimetic.
  • Molecular weight: 169.18
  • Formula: C8H11NO3
  • CLOGP: -0.99
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 4
  • TPSA: 86.71
  • ALOGS: -1.13
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
6 mg P

ADMET properties:

PropertyValueReference
BA (Bioavailability) 3 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
July 13, 1950 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Multiple organ dysfunction syndrome 420.05 23.71 225 12154 51485 46622198
Septic shock 299.56 23.71 188 12191 57705 46615978
Cardiac arrest 249.54 23.71 200 12179 90199 46583484
Cardiogenic shock 215.21 23.71 99 12280 16285 46657398
Shock 199.63 23.71 103 12276 21742 46651941
Hypotension 190.63 23.71 269 12110 232320 46441363
Renal failure 141.38 23.71 162 12217 113432 46560251
Stress cardiomyopathy 124.45 23.71 54 12325 7730 46665953
Acute kidney injury 116.49 23.71 217 12162 235638 46438045
Fatigue 109.28 23.71 16 12363 608681 46065002
Renal injury 104.81 23.71 51 12328 9490 46664193
Propofol infusion syndrome 104.74 23.71 27 12352 754 46672929
Sepsis 104.72 23.71 153 12226 135861 46537822
Respiratory failure 104.26 23.71 127 12252 94689 46578994
Circulatory collapse 103.59 23.71 67 12312 21557 46652126
Vasoplegia syndrome 100.33 23.71 28 12351 1064 46672619
Haemodynamic instability 96.16 23.71 45 12334 7680 46666003
Lactic acidosis 95.40 23.71 76 12303 33833 46639850
Intentional overdose 95.18 23.71 101 12278 64843 46608840
Pulseless electrical activity 93.09 23.71 43 12336 7124 46666559
Pharyngeal haemorrhage 88.56 23.71 22 12357 527 46673156
Metabolic acidosis 84.48 23.71 75 12304 38705 46634978
Nausea 80.93 23.71 41 12338 687413 45986270
Headache 78.21 23.71 16 12363 478336 46195347
Peripheral ischaemia 77.38 23.71 33 12346 4526 46669157
Acute respiratory distress syndrome 76.77 23.71 56 12323 21866 46651817
Pulmonary oedema 74.00 23.71 79 12300 51026 46622657
Renal impairment 72.74 23.71 94 12285 74278 46599405
Ventricular tachycardia 70.21 23.71 48 12331 16919 46656764
Disseminated intravascular coagulation 69.86 23.71 50 12329 18955 46654728
Drug ineffective 69.73 23.71 358 12021 677480 45996203
Arthralgia 69.06 23.71 8 12371 364595 46309088
Ventricular fibrillation 60.97 23.71 38 12341 11458 46662225
Extremity necrosis 60.96 23.71 21 12358 1612 46672071
Acidosis 59.43 23.71 37 12342 11137 46662546
Atrioventricular block first degree 58.86 23.71 30 12349 6156 46667527
Fear 58.18 23.71 42 12337 16130 46657553
Bradycardia 55.95 23.71 78 12301 66220 46607463
Electrocardiogram QRS complex prolonged 53.52 23.71 27 12352 5422 46668261
Ventricular hypokinesia 51.50 23.71 24 12355 4054 46669629
Hyperlactacidaemia 51.16 23.71 20 12359 2195 46671488
Electrocardiogram ST segment elevation 50.59 23.71 23 12356 3672 46670011
Fall 49.73 23.71 13 12366 329084 46344599
Injury 48.36 23.71 59 12320 43968 46629715
Activated partial thromboplastin time prolonged 47.57 23.71 27 12352 6862 46666821
Toxicity to various agents 47.14 23.71 143 12236 211623 46462060
Cardiomyopathy 45.12 23.71 36 12343 16037 46657646
Blood pressure decreased 44.90 23.71 65 12314 57094 46616589
Anhedonia 44.56 23.71 30 12349 10305 46663378
Pain in extremity 43.55 23.71 8 12371 258672 46415011
Serotonin syndrome 43.35 23.71 42 12337 24178 46649505
Cardiotoxicity 42.83 23.71 25 12354 6697 46666986
Drug hypersensitivity 42.22 23.71 7 12372 243818 46429865
Dizziness 41.86 23.71 19 12360 340395 46333288
Anuria 41.83 23.71 30 12349 11401 46662282
Systolic dysfunction 41.79 23.71 15 12364 1299 46672384
Electrocardiogram ST segment depression 40.82 23.71 18 12361 2675 46671008
Pruritus 39.72 23.71 8 12371 242344 46431339
Weight decreased 38.94 23.71 5 12374 210844 46462839
Overdose 38.39 23.71 84 12295 101895 46571788
Hypoxia 37.90 23.71 57 12322 51781 46621902
Unmasking of previously unidentified disease 37.71 23.71 12 12367 719 46672964
Dry gangrene 37.05 23.71 11 12368 522 46673161
Rash 36.48 23.71 25 12354 356487 46317196
Hyperkalaemia 35.99 23.71 55 12324 50654 46623029
Ischaemic hepatitis 35.30 23.71 15 12364 2038 46671645
Tachycardia 35.18 23.71 80 12299 99542 46574141
Unevaluable event 34.07 23.71 51 12328 46124 46627559
Hepatic failure 32.26 23.71 42 12337 33374 46640309
Intestinal ischaemia 32.02 23.71 21 12358 6904 46666779
Cardio-respiratory arrest 31.81 23.71 57 12322 59812 46613871
Patent ductus arteriosus 31.80 23.71 17 12362 3845 46669838
Diarrhoea 30.01 23.71 65 12314 559537 46114146
Acid base balance abnormal 29.80 23.71 8 12371 262 46673421
Oliguria 29.80 23.71 22 12357 8737 46664946
Diabetic macroangiopathy 29.62 23.71 7 12372 135 46673548
Thrombocytopenia 29.54 23.71 87 12292 126494 46547189
Drug intolerance 28.35 23.71 3 12376 147046 46526637
Malaise 27.96 23.71 28 12351 331204 46342479
Insomnia 27.95 23.71 5 12374 164919 46508764
Weight increased 27.84 23.71 5 12374 164468 46509215
Electrocardiogram repolarisation abnormality 27.73 23.71 11 12368 1254 46672429
Pseudomonas infection 27.69 23.71 22 12357 9736 46663947
Nasopharyngitis 27.60 23.71 4 12375 153994 46519689
Supraventricular tachycardia 27.56 23.71 25 12354 13245 46660438
Encephalopathy 27.54 23.71 39 12340 33550 46640133
Alopecia 27.36 23.71 5 12374 162409 46511274
Ventricular extrasystoles 27.31 23.71 23 12356 11040 46662643
Cardiovascular insufficiency 27.11 23.71 11 12368 1330 46672353
Acute coronary syndrome 26.83 23.71 22 12357 10182 46663501
Haemodialysis 26.63 23.71 21 12358 9196 46664487
Constipation 26.02 23.71 7 12372 174090 46499593
Emotional distress 25.69 23.71 36 12343 30671 46643012
Torsade de pointes 25.44 23.71 23 12356 12131 46661552
Altered state of consciousness 25.15 23.71 31 12348 23317 46650366
Diabetes insipidus 25.01 23.71 12 12367 2162 46671521
Polyserositis 24.80 23.71 7 12372 277 46673406
Reversible cerebral vasoconstriction syndrome 24.49 23.71 11 12368 1706 46671977
Arteriospasm coronary 24.48 23.71 14 12365 3607 46670076
Back pain 23.85 23.71 13 12366 210026 46463657
Central nervous system injury 23.83 23.71 6 12373 152 46673531
Hyperdynamic left ventricle 23.83 23.71 6 12373 152 46673531
Renal tubular necrosis 23.79 23.71 21 12358 10738 46662945

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Multiple organ dysfunction syndrome 413.20 19.56 296 13906 63191 29875085
Septic shock 266.80 19.56 229 13973 63378 29874898
Cardiogenic shock 186.75 19.56 110 14092 16751 29921525
Shock 177.38 19.56 119 14083 22740 29915536
Drug ineffective 164.44 19.56 439 13763 339948 29598328
Cardiac arrest 137.05 19.56 193 14009 92657 29845619
Fear 131.44 19.56 75 14127 10750 29927526
Hypotension 130.92 19.56 291 13911 200274 29738002
Respiratory failure 119.57 19.56 189 14013 100453 29837823
Propofol infusion syndrome 116.61 19.56 34 14168 832 29937444
Haemodynamic instability 112.24 19.56 61 14141 7954 29930322
Renal failure 111.03 19.56 210 13992 128756 29809520
Acute respiratory distress syndrome 109.47 19.56 90 14112 23382 29914894
Acute kidney injury 107.20 19.56 328 13874 273514 29664762
Injury 100.66 19.56 83 14119 21648 29916628
Renal injury 93.17 19.56 62 14140 11667 29926609
Fatigue 92.10 19.56 20 14182 320653 29617623
Stress 88.97 19.56 75 14127 20160 29918116
Rhabdomyolysis 86.12 19.56 127 14075 63453 29874823
Anhedonia 85.84 19.56 52 14150 8317 29929959
Emotional distress 81.02 19.56 64 14138 15701 29922575
Sepsis 79.54 19.56 198 14004 146197 29792079
Metabolic acidosis 77.27 19.56 92 14110 37369 29900907
Lactic acidosis 69.94 19.56 80 14122 31133 29907143
Appendicolith 68.68 19.56 23 14179 896 29937380
Dizziness 67.61 19.56 7 14195 194902 29743374
Unevaluable event 63.80 19.56 77 14125 31708 29906568
Headache 62.07 19.56 7 14195 182299 29755977
Stress cardiomyopathy 60.43 19.56 24 14178 1525 29936751
Toxic epidermal necrolysis 60.02 19.56 57 14145 17883 29920393
Diarrhoea 58.52 19.56 44 14158 334059 29604217
Asthenia 57.26 19.56 17 14185 221273 29717003
Hypertransaminasaemia 55.58 19.56 30 14172 3855 29934421
Vasoplegia syndrome 54.19 19.56 21 14181 1250 29937026
Weight decreased 53.41 19.56 5 14197 150916 29787360
Drug ineffective for unapproved indication 51.28 19.56 42 14160 10838 29927438
Myocardial calcification 48.21 19.56 9 14193 24 29938252
Bradycardia 48.13 19.56 100 14102 65426 29872850
Activated partial thromboplastin time prolonged 47.28 19.56 35 14167 7793 29930483
Renal impairment 45.74 19.56 114 14088 84070 29854206
Arthralgia 44.27 19.56 6 14196 135785 29802491
Nausea 43.66 19.56 46 14156 296911 29641365
Pharyngeal haemorrhage 42.55 19.56 15 14187 683 29937593
Pain in extremity 40.77 19.56 3 14199 110218 29828058
Pulseless electrical activity 40.40 19.56 29 14173 6158 29932118
Fall 40.20 19.56 18 14184 181854 29756422
Malaise 39.36 19.56 15 14187 166947 29771329
COVID-19 pneumonia 38.48 19.56 25 14177 4515 29933761
COVID-19 36.98 19.56 44 14158 17834 29920442
Acidosis 36.89 19.56 34 14168 10267 29928009
Thrombocytopenia 36.59 19.56 145 14057 136899 29801377
Decreased appetite 36.11 19.56 13 14189 149897 29788379
Disseminated intravascular coagulation 35.46 19.56 48 14154 22123 29916153
Electrocardiogram QRS complex prolonged 34.90 19.56 23 14179 4254 29934022
Blood pressure decreased 34.73 19.56 72 14130 47003 29891273
Ventricular fibrillation 34.22 19.56 39 14163 15099 29923177
Dyspnoea 32.98 19.56 68 14134 333227 29605049
Ventricular tachycardia 32.73 19.56 48 14154 23814 29914462
Coma 32.37 19.56 64 14138 40385 29897891
Back pain 32.34 19.56 5 14197 102591 29835685
Appendicitis 31.67 19.56 25 14177 6119 29932157
Diabetes insipidus 31.22 19.56 17 14185 2222 29936054
Intestinal ischaemia 31.19 19.56 26 14176 6871 29931405
Torsade de pointes 30.25 19.56 26 14176 7164 29931112
Coagulopathy 29.52 19.56 40 14162 18447 29919829
Electrocardiogram QT prolonged 29.04 19.56 57 14145 35778 29902498
Serotonin syndrome 29.01 19.56 39 14163 17852 29920424
Oliguria 27.50 19.56 25 14177 7414 29930862
Compartment syndrome 26.67 19.56 16 14186 2511 29935765
Catheter site haemorrhage 26.22 19.56 15 14187 2157 29936119
Hypoxia 26.16 19.56 65 14137 47789 29890487
Heparin-induced thrombocytopenia 25.82 19.56 21 14181 5362 29932914
Pruritus 25.62 19.56 12 14190 118192 29820084
Cardiovascular insufficiency 25.52 19.56 13 14189 1483 29936793
Intra-abdominal fluid collection 25.18 19.56 12 14190 1186 29937090
Burkholderia test positive 24.72 19.56 9 14193 450 29937826
Post procedural haemorrhage 24.31 19.56 24 14178 7886 29930390
Peripheral ischaemia 23.90 19.56 20 14182 5314 29932962
Rash 23.63 19.56 34 14168 191855 29746421
Oesophageal ulcer haemorrhage 23.60 19.56 7 14195 182 29938094
Cholangiolitis 23.42 19.56 5 14197 31 29938245
Tachycardia 22.94 19.56 82 14120 73657 29864619
Gait disturbance 22.76 19.56 4 14198 74773 29863503
Cough 22.61 19.56 16 14186 125626 29812650
Mean arterial pressure increased 22.58 19.56 4 14198 7 29938269
Off label use 22.05 19.56 197 14005 249093 29689183
Dehydration 21.88 19.56 16 14186 123523 29814753
Subcutaneous emphysema 20.99 19.56 10 14192 987 29937289
Insomnia 20.96 19.56 9 14193 93327 29844949
Pulmonary haematoma 20.40 19.56 5 14197 61 29938215
Hyperthermia malignant 20.37 19.56 12 14190 1822 29936454
Overdose 19.92 19.56 86 14116 84251 29854025

Pharmacologic Action:

SourceCodeDescription
ATC C01CA03 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
Adrenergic and dopaminergic agents
FDA CS M0003647 Catecholamines
FDA EPC N0000175570 Catecholamine
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D000316 Adrenergic alpha-Agonists
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D013566 Sympathomimetics
MeSH PA D014662 Vasoconstrictor Agents
CHEBI has role CHEBI:25512 neurotransmitters
CHEBI has role CHEBI:35524 sympathomimetic
CHEBI has role CHEBI:35569 alpha-adrenergic receptor agonist
CHEBI has role CHEBI:75771 mus musculus metabolite
CHEBI has role CHEBI:76967 human xenobiotic metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Bronchiectasis indication 12295008 DOID:9563
Bronchitis indication 32398004 DOID:6132
Low blood pressure indication 45007003
Pulmonary emphysema indication 87433001
Asthma indication 195967001 DOID:2841
Asthma management indication 406162001
Acute exacerbation of asthma indication 708038006
Hypovolemia contraindication 28560003
Hypercapnia contraindication 29596007
Hypertensive disorder contraindication 38341003 DOID:10763
Hypoxia contraindication 389086002
Thrombosis contraindication 439127006
Occlusive Vascular Disease contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.41 acidic
pKa2 12.03 acidic
pKa3 12.63 acidic
pKa4 8.83 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Alpha-1A adrenergic receptor GPCR AGONIST Ki 5.82 CHEMBL CHEMBL
Alpha-1B adrenergic receptor GPCR AGONIST Ki 4.69 CHEMBL CHEMBL
Beta-2 adrenergic receptor GPCR AGONIST Kd 5.40 CHEMBL CHEMBL
Alpha-2C adrenergic receptor GPCR AGONIST Ki 7.20 CHEMBL CHEMBL
Beta-1 adrenergic receptor GPCR AGONIST Ki 6 IUPHAR CHEMBL
Alpha-1D adrenergic receptor GPCR AGONIST Ki 7.40 IUPHAR CHEMBL
Alpha-2A adrenergic receptor GPCR AGONIST Ki 7.18 CHEMBL CHEMBL
Alpha-2B adrenergic receptor GPCR Ki 6.48 PDSP
Beta-3 adrenergic receptor GPCR Ki 5.37 PDSP
Sodium-dependent dopamine transporter Transporter Ki 5.07 PDSP
Alpha-2B adrenergic receptor GPCR Ki 7.11 CHEMBL
Adrenergic receptor alpha-1 GPCR Ki 6.41 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.38 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 6.40 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 6.35 CHEMBL
Adrenergic receptor alpha GPCR IC50 7.80 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 6.58 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 8.32 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.22 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.30 CHEMBL
Adrenergic receptor beta GPCR IC50 6 CHEMBL
Mu-type opioid receptor GPCR Ki 4.85 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 6.90 CHEMBL

External reference:

IDSource
4019859 VUID
N0000147945 NUI
D00076 KEGG_DRUG
108341-18-0 SECONDARY_CAS_RN
4018242 VANDF
4019859 VANDF
C0028351 UMLSCUI
CHEBI:18357 CHEBI
E5E PDB_CHEM_ID
439260 PUBCHEM_CID
DB00368 DRUGBANK_ID
CHEMBL1356607 ChEMBL_ID
CHEMBL1434513 ChEMBL_ID
CHEMBL1437 ChEMBL_ID
D009638 MESH_DESCRIPTOR_UI
505 IUPHAR_LIGAND_ID
33 INN_ID
X4W3ENH1CV UNII
7508 RXNORM
2706 MMSL
333906 MMSL
35060 MMSL
5186 MMSL
NOCODE MMSL
d00323 MMSL
001777 NDDF
004718 NDDF
111130009 SNOMEDCT_US
45555007 SNOMEDCT_US
77673009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Norepinephrine Bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9318 INJECTION 1 mg INTRAVENOUS ANDA 24 sections
NOREPINEPHRINE BITARTRATE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0108 INJECTION, SOLUTION 8 mg INTRAVENOUS NDA 24 sections
NOREPINEPHRINE BITARTRATE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0112 INJECTION, SOLUTION 4 mg INTRAVENOUS NDA 24 sections
Levophed HUMAN PRESCRIPTION DRUG LABEL 1 0409-1443 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS NDA 20 sections
Levophed HUMAN PRESCRIPTION DRUG LABEL 1 0409-1443 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS NDA 20 sections
LEVOPHED Human prescription drug label 1 0409-3375 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS NDA 27 sections
LEVOPHED Human prescription drug label 1 0409-3375 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS NDA 27 sections
Norepinephrine Bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 0703-1153 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS ANDA 24 sections
Norepinephrine Bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 0703-1153 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS ANDA 24 sections
NOREPINEPHRINE BITARTRATE HUMAN PRESCRIPTION DRUG LABEL 1 0781-3755 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS ANDA 24 sections
Norepinephrine bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 36000-162 INJECTION 1 mg INTRAVENOUS ANDA 18 sections
LEVOPHED(R) NOREPINEPHRINE BITARTRATE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1315 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS NDA 12 sections
Norepinephrine Bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 52533-164 INJECTION, SOLUTION 64 ug INTRAVENOUS unapproved drug other 7 sections
Norepinephrine Bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 52533-165 INJECTION, SOLUTION 16 ug INTRAVENOUS unapproved drug other 7 sections
Norepinephrine Bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 52533-166 INJECTION, SOLUTION 32 ug INTRAVENOUS unapproved drug other 7 sections
Norepinephrine Bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 63323-940 SOLUTION 1 mg INTRAVENOUS ANDA 24 sections
Norepinephrine bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 67457-852 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS ANDA 24 sections
Norepinephrine bitartrate Human Prescription Drug Label 1 68083-437 INJECTION 1 mg INTRAVENOUS ANDA 24 sections
Norepinephrine Bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 70121-1576 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS ANDA 23 sections
Norepinephrine bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 72078-002 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS ANDA 24 sections
NOREPINEPHRINE BITARTRATE HUMAN PRESCRIPTION DRUG LABEL 1 72572-481 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS ANDA 24 sections