norepinephrine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
sympathomimetic, phenethyl derivatives 1960 51-41-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • norepinephrine
  • (R)-Norepinephrine
  • arterenol
  • levarterenol
  • noradrenaline
  • norepinephrine bitartrate
  • (-)-noradrenaline
Precursor of epinephrine that is secreted by the ADRENAL MEDULLA and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers, and of the diffuse projection system in the brain that arises from the LOCUS CERULEUS. It is also found in plants and is used pharmacologically as a sympathomimetic.
  • Molecular weight: 169.18
  • Formula: C8H11NO3
  • CLOGP: -0.99
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 4
  • TPSA: 86.71
  • ALOGS: -1.13
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
6 mg P

ADMET properties:

PropertyValueReference
BA (Bioavailability) 3 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
July 13, 1950 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Multiple organ dysfunction syndrome 362.02 24.80 199 12612 50138 50542175
Septic shock 256.81 24.80 167 12644 57008 50535305
Cardiac arrest 238.21 24.80 185 12626 83466 50508847
Shock 191.87 24.80 97 12714 20553 50571760
Cardiogenic shock 189.37 24.80 88 12723 15511 50576802
Metabolic acidosis 178.12 24.80 115 12696 38710 50553603
Drug ineffective 155.32 24.80 505 12306 818828 49773485
Stress cardiomyopathy 153.15 24.80 62 12749 7825 50584488
Intentional overdose 145.51 24.80 123 12688 62381 50529932
Hypotension 145.42 24.80 233 12578 235236 50357077
Acute kidney injury 144.03 24.80 228 12583 227830 50364483
Peripheral ischaemia 142.81 24.80 50 12761 4226 50588087
Renal failure 129.69 24.80 147 12664 106486 50485827
Fatigue 127.99 24.80 15 12796 707586 49884727
Renal injury 112.05 24.80 51 12760 8560 50583753
Respiratory failure 111.34 24.80 126 12685 91055 50501258
Myoglobin urine present 107.96 24.80 24 12787 366 50591947
Pulseless electrical activity 106.66 24.80 46 12765 6795 50585518
Lactic acidosis 106.28 24.80 79 12732 33276 50559037
Haemodynamic instability 105.92 24.80 48 12763 7976 50584337
Acute respiratory distress syndrome 105.42 24.80 66 12745 21033 50571280
Electrocardiogram QRS complex prolonged 103.71 24.80 42 12769 5302 50587011
Propofol infusion syndrome 91.86 24.80 24 12787 742 50591571
Hyperlactacidaemia 91.13 24.80 31 12780 2402 50589911
Pharyngeal haemorrhage 90.06 24.80 22 12789 515 50591798
Circulatory collapse 88.60 24.80 58 12753 19942 50572371
Pulmonary oedema 87.45 24.80 83 12728 48855 50543458
Bradycardia 85.44 24.80 93 12718 64333 50527980
Headache 79.43 24.80 16 12795 506519 50085794
Toxicity to various agents 78.77 24.80 169 12642 212330 50379983
Arthralgia 77.39 24.80 10 12801 438692 50153621
Nausea 76.52 24.80 42 12769 705356 49886957
Renal impairment 74.91 24.80 94 12717 75567 50516746
Ventricular hypokinesia 72.85 24.80 30 12781 3950 50588363
Ventricular tachycardia 72.82 24.80 47 12764 15774 50576539
Extremity necrosis 72.23 24.80 23 12788 1448 50590865
Atrioventricular block first degree 72.17 24.80 34 12777 6167 50586146
Dry gangrene 71.77 24.80 18 12793 471 50591842
Sepsis 70.39 24.80 123 12688 132802 50459511
Serotonin syndrome 68.74 24.80 54 12757 24659 50567654
Toxic encephalopathy 66.54 24.80 31 12780 5484 50586829
Fear 66.41 24.80 43 12768 14506 50577807
Tachycardia 64.47 24.80 101 12710 99662 50492651
Ventricular fibrillation 62.94 24.80 37 12774 10522 50581791
Acidosis 61.39 24.80 36 12775 10191 50582122
Overdose 60.37 24.80 98 12713 99629 50492684
Electrocardiogram ST segment elevation 56.26 24.80 24 12787 3449 50588864
Fall 55.83 24.80 9 12802 334923 50257390
Anuria 55.71 24.80 35 12776 11209 50581104
Diabetes insipidus 54.33 24.80 21 12790 2343 50589970
Disseminated intravascular coagulation 53.25 24.80 40 12771 17095 50575218
Reversible cerebral vasoconstriction syndrome 52.92 24.80 20 12791 2099 50590214
Amylase increased 51.84 24.80 26 12785 5404 50586909
Pruritus 51.07 24.80 6 12805 283562 50308751
Cardiotoxicity 50.98 24.80 28 12783 6999 50585314
Troponin increased 49.85 24.80 29 12782 8089 50584224
Anhedonia 48.08 24.80 30 12781 9494 50582819
Alopecia 47.20 24.80 4 12807 245043 50347270
Rash 45.92 24.80 27 12784 437444 50154869
Injury 45.57 24.80 59 12752 48866 50543447
Cardiomyopathy 45.38 24.80 35 12776 15551 50576762
Hypoxia 45.06 24.80 60 12751 51063 50541250
Vasoplegia syndrome 44.90 24.80 15 12796 1099 50591214
Systolic dysfunction 44.54 24.80 16 12795 1456 50590857
Abdominal discomfort 44.02 24.80 4 12807 231637 50360676
Drug intolerance 43.82 24.80 3 12808 219101 50373212
Drug hypersensitivity 43.52 24.80 6 12805 251004 50341309
Hyperkalaemia 43.25 24.80 57 12754 48032 50544281
Electrocardiogram ST segment depression 42.09 24.80 18 12793 2602 50589711
Pain in extremity 41.88 24.80 9 12802 272856 50319457
Dizziness 41.38 24.80 18 12793 346351 50245962
Electrocardiogram QT prolonged 41.35 24.80 58 12753 51828 50540485
Acid base balance abnormal 40.81 24.80 10 12801 237 50592076
Distributive shock 40.69 24.80 13 12798 827 50591486
Drug ineffective for unapproved indication 39.72 24.80 37 12774 21244 50571069
Unevaluable event 38.97 24.80 53 12758 46013 50546300
Blood lactate dehydrogenase increased 38.43 24.80 35 12776 19527 50572786
Alanine aminotransferase increased 38.21 24.80 75 12736 88284 50504029
Mydriasis 37.98 24.80 27 12784 10600 50581713
Nasopharyngitis 37.55 24.80 3 12808 192924 50399389
Unmasking of previously unidentified disease 37.52 24.80 12 12799 766 50591547
Diabetic macroangiopathy 35.86 24.80 8 12803 124 50592189
Constipation 35.83 24.80 3 12808 185705 50406608
Blood creatine phosphokinase increased 34.80 24.80 38 12773 26329 50565984
Weight increased 34.57 24.80 5 12806 201886 50390427
Renal tubular necrosis 34.43 24.80 25 12786 10143 50582170
Oliguria 34.37 24.80 23 12788 8193 50584120
Ischaemic hepatitis 33.48 24.80 14 12797 1915 50590398
Diarrhoea 32.92 24.80 62 12749 588414 50003899
Patent ductus arteriosus 32.71 24.80 17 12794 3803 50588510
Cardio-respiratory arrest 32.63 24.80 53 12758 53839 50538474
Weight decreased 32.53 24.80 8 12803 221237 50371076
Back pain 32.27 24.80 8 12803 220022 50372291
Infusion related reaction 32.00 24.80 3 12808 169554 50422759
Activated partial thromboplastin time prolonged 31.89 24.80 20 12791 6382 50585931
Suicide attempt 31.49 24.80 51 12760 51681 50540632
Hypersensitivity 31.21 24.80 8 12803 215153 50377160
Coagulopathy 31.20 24.80 30 12781 17914 50574399
Premature delivery 31.05 24.80 34 12777 23629 50568684
Emotional distress 30.57 24.80 37 12774 28626 50563687
Swelling 30.05 24.80 7 12804 200865 50391448
Compartment syndrome 29.82 24.80 13 12798 1969 50590344
Coma 29.23 24.80 52 12759 56827 50535486
Encephalopathy 28.83 24.80 39 12772 33672 50558641
Electrocardiogram repolarisation abnormality 28.79 24.80 11 12800 1189 50591124
Malaise 28.30 24.80 26 12785 335506 50256807
Local anaesthetic systemic toxicity 27.72 24.80 9 12802 603 50591710
Wrong product administered 27.34 24.80 17 12794 5343 50586970
Blood pressure decreased 27.31 24.80 50 12761 55859 50536454
Ventricular extrasystoles 27.14 24.80 22 12789 10494 50581819
Sinus bradycardia 26.70 24.80 24 12787 13159 50579154
Insomnia 26.33 24.80 6 12805 174859 50417454
Altered state of consciousness 26.21 24.80 30 12781 21880 50570433
Intestinal ischaemia 26.09 24.80 18 12793 6739 50585574
Respiratory distress 25.66 24.80 35 12776 30454 50561859
Polyserositis 25.47 24.80 7 12804 263 50592050
Vasoconstriction 25.35 24.80 8 12803 489 50591824
Gait disturbance 25.02 24.80 4 12807 150001 50442312
Off label use 24.99 24.80 205 12606 474221 50118092

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Multiple organ dysfunction syndrome 451.17 21.10 314 13993 62802 29497418
Drug ineffective 312.79 21.10 595 13712 362575 29197645
Cardiogenic shock 291.38 21.10 155 14152 19035 29541185
Appendicolith 230.79 21.10 80 14227 3400 29556820
Septic shock 205.16 21.10 198 14109 62362 29497858
Appendicitis 165.22 21.10 82 14225 8697 29551523
Fear 136.38 21.10 74 14233 9430 29550790
Sepsis 135.48 21.10 245 14062 142437 29417783
Cardiac arrest 122.19 21.10 177 14130 85414 29474806
Acute kidney injury 114.35 21.10 333 13974 264934 29295286
Off label use 112.32 21.10 359 13948 300441 29259779
Shock 110.88 21.10 88 14219 21316 29538904
Respiratory failure 109.36 21.10 180 14127 96951 29463269
Injury 108.85 21.10 83 14224 18963 29541257
Hypotension 105.70 21.10 266 14041 194088 29366132
Propofol infusion syndrome 105.04 21.10 31 14276 776 29559444
Toxic epidermal necrolysis 101.30 21.10 78 14229 18075 29542145
Renal failure 99.15 21.10 193 14114 118406 29441814
Renal injury 94.92 21.10 60 14247 10142 29550078
Ventricular fibrillation 94.90 21.10 71 14236 15762 29544458
Anhedonia 92.14 21.10 52 14255 7148 29553072
Fatigue 87.24 21.10 23 14284 316798 29243422
Emotional distress 87.06 21.10 64 14243 13831 29546389
Rhabdomyolysis 85.58 21.10 125 14182 60683 29499537
Ascites 84.16 21.10 96 14211 36523 29523697
Metabolic acidosis 81.97 21.10 96 14211 37566 29522654
Acute respiratory distress syndrome 75.76 21.10 73 14234 22862 29537358
Lactic acidosis 74.12 21.10 82 14225 30165 29530055
Haemodynamic instability 71.42 21.10 46 14261 8027 29552193
Unevaluable event 68.14 21.10 78 14229 29773 29530447
Diarrhoea 64.39 21.10 41 14266 332657 29227563
Headache 62.55 21.10 6 14301 174001 29386219
Abdominal distension 59.72 21.10 91 14216 45820 29514400
Stress 57.42 21.10 61 14246 21429 29538791
Asthenia 56.59 21.10 17 14290 215233 29344987
Stress cardiomyopathy 55.47 21.10 23 14284 1601 29558619
Dry gangrene 55.20 21.10 16 14291 375 29559845
Dizziness 53.57 21.10 13 14294 189671 29370549
Myocardial calcification 52.75 21.10 10 14297 29 29560191
Arthralgia 49.66 21.10 5 14302 139612 29420608
Renal impairment 48.97 21.10 116 14191 81217 29479003
Burkholderia test positive 47.61 21.10 18 14289 981 29559239
Vasoplegia syndrome 46.97 21.10 20 14287 1488 29558732
Fall 46.53 21.10 14 14293 177164 29383056
Hypertransaminasaemia 46.01 21.10 26 14281 3580 29556640
Anion gap 45.25 21.10 16 14291 720 29559500
Drug ineffective for unapproved indication 44.59 21.10 44 14263 14170 29546050
Acidosis 44.12 21.10 37 14270 9668 29550552
Hyponatraemia 43.48 21.10 99 14208 67534 29492686
General physical health deterioration 42.92 21.10 128 14179 102729 29457491
Pharyngeal haemorrhage 42.87 21.10 15 14292 654 29559566
Pain in extremity 41.87 21.10 3 14304 110430 29449790
Coma 41.46 21.10 71 14236 39379 29520841
Diabetes insipidus 40.70 21.10 21 14286 2413 29557807
Electrocardiogram QRS complex prolonged 40.30 21.10 25 14282 4085 29556135
Decreased appetite 37.21 21.10 12 14295 145330 29414890
Dyspnoea 35.61 21.10 65 14242 326667 29233553
Back pain 35.49 21.10 4 14303 102280 29457940
Electrocardiogram QT prolonged 35.32 21.10 63 14244 36074 29524146
Peripheral ischaemia 35.30 21.10 25 14282 5094 29555126
Malaise 33.12 21.10 18 14289 159584 29400636
Pulseless electrical activity 32.32 21.10 26 14281 6408 29553812
Rash 31.93 21.10 27 14280 189792 29370428
Heparin-induced thrombocytopenia 31.32 21.10 23 14284 4956 29555264
Pruritus 31.07 21.10 9 14298 116840 29443380
COVID-19 pneumonia 30.84 21.10 30 14277 9492 29550728
Ventricular tachycardia 29.68 21.10 45 14262 22529 29537691
Bradycardia 29.57 21.10 84 14223 65545 29494675
Compartment syndrome 29.46 21.10 17 14290 2435 29557785
Drug reaction with eosinophilia and systemic symptoms 28.90 21.10 50 14257 27942 29532278
Overdose 28.35 21.10 94 14213 79725 29480495
Product use in unapproved indication 27.97 21.10 99 14208 86776 29473444
Laryngomalacia 27.92 21.10 9 14298 304 29559916
Intestinal ischaemia 27.33 21.10 24 14283 6668 29553552
Oliguria 27.15 21.10 25 14282 7387 29552833
Coagulopathy 26.88 21.10 38 14269 17869 29542351
Hyperdynamic left ventricle 26.44 21.10 7 14300 116 29560104
Symmetrical drug-related intertriginous and flexural exanthema 26.35 21.10 8 14299 221 29559999
COVID-19 25.70 21.10 55 14252 35959 29524261
Hypercapnia 25.23 21.10 18 14289 3708 29556512
Cholangiolitis 25.14 21.10 5 14302 20 29560200
Gait disturbance 25.11 21.10 3 14304 73346 29486874
Disseminated intravascular coagulation 25.10 21.10 39 14268 19941 29540279
Activated partial thromboplastin time prolonged 24.34 21.10 24 14283 7718 29552502
Pulse absent 24.29 21.10 20 14287 5093 29555127
Pneumonia acinetobacter 23.94 21.10 6 14301 79 29560141
Serotonin syndrome 23.15 21.10 35 14272 17477 29542743
Pneumatosis intestinalis 23.07 21.10 16 14291 3153 29557067
Dehydration 22.29 21.10 14 14293 114734 29445486
Liver function test increased 22.09 21.10 28 14279 11857 29548363
Insomnia 21.54 21.10 8 14299 88753 29471467
Mean arterial pressure increased 21.53 21.10 4 14303 10 29560210
Cough 21.31 21.10 18 14289 126709 29433511
Chest pain 21.28 21.10 14 14293 111959 29448261
Respiratory gas exchange disorder 21.21 21.10 8 14299 433 29559787

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Multiple organ dysfunction syndrome 736.69 20.78 475 25398 100938 64371921
Drug ineffective 504.26 20.78 1062 24811 839185 63633674
Cardiogenic shock 444.60 20.78 230 25643 32197 64440662
Septic shock 414.77 20.78 341 25532 105096 64367763
Cardiac arrest 309.90 20.78 344 25529 153720 64319139
Shock 271.74 20.78 177 25696 38063 64434796
Appendicolith 245.64 20.78 80 25793 3389 64469470
Metabolic acidosis 230.80 20.78 206 25667 70752 64402107
Acute kidney injury 209.24 20.78 516 25357 448724 64024135
Fatigue 204.99 20.78 29 25844 748701 63724158
Hypotension 203.79 20.78 462 25411 380512 64092347
Renal failure 202.65 20.78 303 25570 181385 64291474
Respiratory failure 201.88 20.78 284 25589 160899 64311960
Sepsis 191.33 20.78 336 25537 230005 64242854
Propofol infusion syndrome 189.92 20.78 55 25818 1562 64471297
Stress cardiomyopathy 184.95 20.78 85 25788 9172 64463687
Renal injury 179.04 20.78 98 25775 15331 64457528
Acute respiratory distress syndrome 165.62 20.78 132 25741 38803 64434056
Haemodynamic instability 165.57 20.78 92 25781 14820 64458039
Fear 159.69 20.78 100 25773 20071 64452788
Lactic acidosis 156.90 20.78 156 25717 61254 64411605
Ventricular fibrillation 156.24 20.78 105 25768 23755 64449104
Appendicitis 148.69 20.78 83 25790 13486 64459373
Headache 145.86 20.78 20 25853 529447 63943412
Peripheral ischaemia 142.96 20.78 69 25804 8309 64464550
Intentional overdose 137.79 20.78 175 25698 89769 64383090
Off label use 133.19 20.78 553 25320 632253 63840606
Arthralgia 125.86 20.78 15 25858 442245 64030614
Dry gangrene 123.73 20.78 34 25839 794 64472065
Electrocardiogram QRS complex prolonged 122.07 20.78 64 25809 9180 64463679
Anhedonia 118.79 20.78 72 25801 13634 64459225
Pulseless electrical activity 118.40 20.78 70 25803 12669 64460190
Pharyngeal haemorrhage 115.47 20.78 35 25838 1167 64471692
Injury 110.52 20.78 124 25749 55868 64416991
Renal impairment 108.07 20.78 194 25679 134823 64338036
Fall 105.16 20.78 20 25853 416806 64056053
Unevaluable event 98.25 20.78 111 25762 50378 64422481
Rhabdomyolysis 95.03 20.78 148 25725 91578 64381281
Ventricular tachycardia 94.87 20.78 91 25782 34174 64438685
Vasoplegia syndrome 93.88 20.78 37 25836 2730 64470129
Diarrhoea 93.07 20.78 92 25781 722612 63750247
Dizziness 92.24 20.78 29 25844 430134 64042725
Bradycardia 92.20 20.78 168 25705 118051 64354808
Acidosis 90.24 20.78 67 25806 17728 64455131
Diabetes insipidus 88.69 20.78 41 25832 4480 64468379
Toxic epidermal necrolysis 88.63 20.78 91 25782 37075 64435784
Hyperlactacidaemia 85.99 20.78 41 25832 4803 64468056
Emotional distress 85.51 20.78 88 25785 35950 64436909
Pain in extremity 84.39 20.78 11 25862 303074 64169785
Weight decreased 82.94 20.78 9 25864 285730 64187129
Myoglobin urine present 82.51 20.78 23 25850 567 64472292
Drug ineffective for unapproved indication 81.15 20.78 80 25793 31053 64441806
Pruritus 80.87 20.78 14 25859 312386 64160473
Serotonin syndrome 79.22 20.78 88 25785 39194 64433665
Overdose 74.58 20.78 184 25689 159382 64313477
Extremity necrosis 73.71 20.78 31 25842 2703 64470156
Rash 71.82 20.78 48 25825 458501 64014358
Electrocardiogram QT prolonged 71.12 20.78 120 25753 79328 64393531
Ascites 69.78 20.78 104 25769 61897 64410962
Circulatory collapse 68.76 20.78 76 25797 33656 64439203
Malaise 68.31 20.78 37 25836 396210 64076649
Back pain 67.45 20.78 10 25863 250161 64222698
Pulmonary oedema 66.70 20.78 116 25757 78558 64394301
Weight increased 66.51 20.78 5 25868 213343 64259516
Disseminated intravascular coagulation 66.14 20.78 73 25800 32275 64440584
Myocardial calcification 65.24 20.78 12 25861 36 64472823
Electrocardiogram ST segment elevation 65.13 20.78 39 25834 7220 64465639
Coma 65.12 20.78 122 25751 87493 64385366
Toxicity to various agents 64.90 20.78 303 25570 363210 64109649
Tachycardia 63.14 20.78 166 25707 149413 64323446
Nausea 63.01 20.78 139 25734 785661 63687198
Anuria 57.53 20.78 53 25820 18911 64453948
Nasopharyngitis 57.32 20.78 6 25867 196067 64276792
Oliguria 56.84 20.78 47 25826 14529 64458330
Asthenia 56.68 20.78 53 25820 427991 64044868
Dyspnoea 56.05 20.78 129 25744 718545 63754314
Atrioventricular block first degree 55.73 20.78 41 25832 10693 64462166
Activated partial thromboplastin time prolonged 55.59 20.78 44 25829 12787 64460072
Cardiotoxicity 55.06 20.78 40 25833 10234 64462625
Compartment syndrome 55.02 20.78 29 25844 4203 64468656
Intestinal ischaemia 53.06 20.78 41 25832 11508 64461351
Ventricular hypokinesia 52.79 20.78 35 25838 7734 64465125
Drug intolerance 51.86 20.78 7 25866 187985 64284874
Alopecia 51.30 20.78 4 25869 165686 64307173
Abdominal discomfort 49.80 20.78 7 25866 182315 64290544
Decreased appetite 48.82 20.78 26 25847 281263 64191596
Peripheral swelling 48.66 20.78 12 25861 209141 64263718
Coagulopathy 47.08 20.78 61 25812 31859 64441000
Sinusitis 46.68 20.78 3 25870 145925 64326934
Anion gap 46.45 20.78 20 25853 1847 64471012
Distributive shock 46.37 20.78 20 25853 1855 64471004
Gait disturbance 46.11 20.78 7 25866 172148 64300711
Heparin-induced thrombocytopenia 45.41 20.78 33 25840 8446 64464413
Hyperdynamic left ventricle 43.71 20.78 12 25861 279 64472580
Cardiovascular insufficiency 42.92 20.78 21 25852 2603 64470256
COVID-19 treatment 42.87 20.78 13 25860 434 64472425
Reversible cerebral vasoconstriction syndrome 42.11 20.78 20 25853 2322 64470537
Muscle spasms 42.03 20.78 4 25869 141019 64331840
Renal tubular necrosis 41.95 20.78 48 25825 22062 64450797
Blood pressure increased 41.93 20.78 9 25864 172543 64300316
Hypoaesthesia 41.31 20.78 4 25869 139104 64333755
Insomnia 41.15 20.78 14 25859 197822 64275037
Hypoxia 40.45 20.78 101 25772 88048 64384811
Cough 40.44 20.78 37 25836 302111 64170748
Stress 39.72 20.78 80 25793 60454 64412405
Abdominal pain upper 38.89 20.78 11 25862 175019 64297840
Left ventricle outflow tract obstruction 38.12 20.78 11 25862 308 64472551
COVID-19 37.97 20.78 82 25791 65058 64407801
Blood pressure decreased 37.71 20.78 97 25776 86102 64386757
Hypersensitivity 37.37 20.78 16 25857 196436 64276423
Pulse absent 37.31 20.78 30 25843 8916 64463943
Paraesthesia 37.11 20.78 5 25868 134517 64338342
Toxic encephalopathy 36.92 20.78 31 25842 9784 64463075
Cardiomyopathy 36.68 20.78 48 25825 25308 64447551
Hyperkalaemia 36.46 20.78 106 25767 101023 64371836
Hypertransaminasaemia 36.28 20.78 27 25846 7164 64465695
Respiratory gas exchange disorder 36.01 20.78 13 25860 752 64472107
Ischaemic hepatitis 35.94 20.78 20 25853 3226 64469633
Burkholderia test positive 35.57 20.78 12 25861 567 64472292
Myalgia 35.18 20.78 10 25863 158607 64314252
Alanine aminotransferase increased 35.05 20.78 129 25744 138902 64333957
Mydriasis 33.82 20.78 36 25837 15276 64457583
Acid base balance abnormal 33.78 20.78 10 25863 307 64472552
Systolic dysfunction 33.48 20.78 19 25854 3183 64469676
COVID-19 pneumonia 33.31 20.78 37 25836 16467 64456392
Arteriospasm coronary 33.26 20.78 23 25850 5442 64467417
General physical health deterioration 33.21 20.78 166 25707 204259 64268600
Abdominal distension 33.06 20.78 99 25774 95895 64376964
Electrocardiogram ST segment depression 32.82 20.78 21 25852 4368 64468491
Bronchitis 32.62 20.78 3 25870 108740 64364119
Thrombocytopenia 32.40 20.78 176 25697 223625 64249234
Nervous system disorder 32.32 20.78 43 25830 23035 64449824
Swelling 32.18 20.78 12 25861 160206 64312653
Drug hypersensitivity 31.95 20.78 29 25844 237786 64235073
Torsade de pointes 31.77 20.78 37 25836 17326 64455533
Cardio-respiratory arrest 31.58 20.78 99 25774 98294 64374565
Urticaria 31.38 20.78 10 25863 147307 64325552
Diabetic macroangiopathy 31.34 20.78 8 25865 139 64472720
Injection site pain 31.07 20.78 4 25869 111404 64361455
Completed suicide 30.59 20.78 27 25846 224387 64248472
Infusion related reaction 30.32 20.78 14 25859 164453 64308406
Unmasking of previously unidentified disease 29.41 20.78 14 25859 1633 64471226
Neuropathy peripheral 28.81 20.78 6 25867 117519 64355340
Erythema 28.65 20.78 20 25853 187050 64285809
Suicide attempt 28.10 20.78 77 25796 70930 64401929
Chest pain 28.03 20.78 32 25841 235948 64236911
Mean arterial pressure increased 27.44 20.78 6 25867 51 64472808
Lower respiratory tract infection 27.36 20.78 3 25870 94611 64378248
Dehydration 27.29 20.78 28 25845 216735 64256124
Necrosis 27.07 20.78 24 25849 8147 64464712
Vasoconstriction 27.07 20.78 10 25863 618 64472241
Pneumonia acinetobacter 26.99 20.78 7 25866 130 64472729
Product use in unapproved indication 26.98 20.78 141 25732 176477 64296382
Muscular weakness 26.49 20.78 9 25864 127329 64345530
Palpitations 26.31 20.78 5 25868 104483 64368376
Blood creatinine increased 26.24 20.78 116 25757 135666 64337193
Respiratory distress 26.17 20.78 62 25811 52269 64420590
Therapeutic product effect decreased 26.08 20.78 7 25866 115344 64357515
Stomatitis 26.05 20.78 6 25867 109599 64363260
Hepatic failure 25.96 20.78 64 25809 55330 64417529
Hyponatraemia 25.90 20.78 123 25750 148216 64324643
Electrocardiogram P wave abnormal 25.80 20.78 8 25865 288 64472571
Amylase increased 25.44 20.78 25 25848 9660 64463199
Oropharyngeal pain 25.24 20.78 3 25870 88864 64383995
Troponin increased 25.20 20.78 31 25842 15368 64457491
Cholangiolitis 25.16 20.78 5 25868 25 64472834
Ventricular arrhythmia 25.00 20.78 22 25851 7393 64465466
Catheter site haemorrhage 24.88 20.78 18 25855 4573 64468286
Procedural hypotension 24.73 20.78 13 25860 1873 64470986
Pseudomonas infection 24.55 20.78 33 25840 17850 64455009
Mobility decreased 24.13 20.78 3 25870 85837 64387022
Liver function test increased 24.09 20.78 44 25829 30926 64441933
Contusion 23.80 20.78 8 25865 113957 64358902
Product contamination microbial 23.76 20.78 10 25863 873 64471986
Blood phosphorus increased 23.68 20.78 18 25855 4928 64467931
Confusional state 23.54 20.78 43 25830 261101 64211758
Influenza 23.10 20.78 7 25866 106524 64366335
Asthma 23.05 20.78 5 25868 95220 64377639
Pneumatosis intestinalis 22.80 20.78 18 25855 5211 64467648
Local anaesthetic systemic toxicity 22.68 20.78 9 25864 676 64472183
Drug reaction with eosinophilia and systemic symptoms 22.67 20.78 60 25813 54157 64418702
Leukocytosis 22.55 20.78 48 25825 37692 64435167
Wrong product administered 22.30 20.78 21 25852 7699 64465160
Coma scale abnormal 22.18 20.78 21 25852 7753 64465106
Pneumomediastinum 22.00 20.78 14 25859 2886 64469973
Systolic anterior motion of mitral valve 21.96 20.78 5 25868 52 64472807
Mental status changes 21.93 20.78 64 25809 61098 64411761
Contraindicated product administered 21.78 20.78 8 25865 107821 64365038
Brain death 21.77 20.78 17 25856 4844 64468015
Hypoxic-ischaemic encephalopathy 21.71 20.78 20 25853 7132 64465727
Herpes zoster 21.70 20.78 3 25870 79184 64393675
Acute respiratory failure 21.63 20.78 56 25817 49878 64422981
Vasodilatation 21.49 20.78 14 25859 3004 64469855
Central nervous system injury 21.44 20.78 6 25867 150 64472709
Ischaemia 21.41 20.78 20 25853 7258 64465601
Gangrene 21.27 20.78 20 25853 7318 64465541
Chest discomfort 21.22 20.78 10 25863 116096 64356763
Cholestasis 21.19 20.78 52 25821 44820 64428039
Balance disorder 21.16 20.78 4 25869 83922 64388937
Urinary tract infection 20.99 20.78 38 25835 231558 64241301

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01CA03 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
Adrenergic and dopaminergic agents
FDA CS M0003647 Catecholamines
FDA EPC N0000175570 Catecholamine
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D000316 Adrenergic alpha-Agonists
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D013566 Sympathomimetics
MeSH PA D014662 Vasoconstrictor Agents
CHEBI has role CHEBI:25512 neurotransmitters
CHEBI has role CHEBI:35524 sympathomimetic
CHEBI has role CHEBI:35569 alpha-adrenergic agonists
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:76967 human xenobiotic metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Bronchiectasis indication 12295008 DOID:9563
Bronchitis indication 32398004 DOID:6132
Low blood pressure indication 45007003
Pulmonary emphysema indication 87433001
Asthma indication 195967001 DOID:2841
Asthma management indication 406162001
Acute exacerbation of asthma indication 708038006
Hypovolemia contraindication 28560003
Hypercapnia contraindication 29596007
Hypertensive disorder contraindication 38341003 DOID:10763
Hypoxia contraindication 389086002
Thrombosis contraindication 439127006
Occlusive Vascular Disease contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.41 acidic
pKa2 12.03 acidic
pKa3 12.63 acidic
pKa4 8.83 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Alpha-2C adrenergic receptor GPCR AGONIST Ki 7.20 CHEMBL CHEMBL
Alpha-1A adrenergic receptor GPCR AGONIST Ki 5.82 CHEMBL CHEMBL
Alpha-1D adrenergic receptor GPCR AGONIST Ki 7.40 IUPHAR CHEMBL
Alpha-1B adrenergic receptor GPCR AGONIST Ki 4.69 CHEMBL CHEMBL
Beta-2 adrenergic receptor GPCR AGONIST Kd 5.40 CHEMBL CHEMBL
Alpha-2A adrenergic receptor GPCR AGONIST Ki 7.18 CHEMBL CHEMBL
Beta-1 adrenergic receptor GPCR AGONIST Ki 6 IUPHAR CHEMBL
D(1A) dopamine receptor GPCR Kd 4.30 CHEMBL
D(2) dopamine receptor GPCR Ki 5.89 CHEMBL
Alpha-2B adrenergic receptor GPCR Ki 6.48 PDSP
Beta-3 adrenergic receptor GPCR Ki 5.37 PDSP
Sodium-dependent dopamine transporter Transporter Ki 5.07 PDSP
Mu-type opioid receptor GPCR Ki 4.85 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.22 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 6.90 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.30 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 6.35 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.38 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 6.58 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 6.40 CHEMBL
Adrenergic receptor alpha-2 GPCR Ki 8.32 CHEMBL
Adrenergic receptor alpha-1 GPCR Ki 6.41 CHEMBL
Adrenergic receptor alpha GPCR IC50 7.80 CHEMBL
Adrenergic receptor beta GPCR IC50 6 CHEMBL
Alpha-2C adrenergic receptor GPCR Ki 6.19 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 5.24 CHEMBL
Alpha-2B adrenergic receptor GPCR Ki 7.11 CHEMBL

External reference:

IDSource
4019859 VUID
N0000147945 NUI
D00076 KEGG_DRUG
108341-18-0 SECONDARY_CAS_RN
4018242 VANDF
4019859 VANDF
C0028351 UMLSCUI
CHEBI:33569 CHEBI
LT4 PDB_CHEM_ID
CHEMBL1434513 ChEMBL_ID
CHEMBL1437 ChEMBL_ID
DB00368 DRUGBANK_ID
CHEMBL1356607 ChEMBL_ID
D009638 MESH_DESCRIPTOR_UI
439260 PUBCHEM_CID
33 INN_ID
484 IUPHAR_LIGAND_ID
X4W3ENH1CV UNII
7508 RXNORM
2706 MMSL
333906 MMSL
35060 MMSL
5186 MMSL
NOCODE MMSL
d00323 MMSL
001777 NDDF
004718 NDDF
111130009 SNOMEDCT_US
45555007 SNOMEDCT_US
77673009 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Norepinephrine Bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9318 INJECTION 1 mg INTRAVENOUS ANDA 24 sections
NOREPINEPHRINE BITARTRATE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0108 INJECTION, SOLUTION 8 mg INTRAVENOUS NDA 24 sections
NOREPINEPHRINE BITARTRATE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0108 INJECTION, SOLUTION 8 mg INTRAVENOUS NDA 24 sections
NOREPINEPHRINE BITARTRATE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0112 INJECTION, SOLUTION 4 mg INTRAVENOUS NDA 24 sections
NOREPINEPHRINE BITARTRATE HUMAN PRESCRIPTION DRUG LABEL 1 0338-0112 INJECTION, SOLUTION 4 mg INTRAVENOUS NDA 24 sections
Levophed HUMAN PRESCRIPTION DRUG LABEL 1 0409-1443 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS NDA 20 sections
Levophed HUMAN PRESCRIPTION DRUG LABEL 1 0409-1443 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS NDA 20 sections
LEVOPHED Human prescription drug label 1 0409-3375 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS NDA 27 sections
LEVOPHED Human prescription drug label 1 0409-3375 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS NDA 27 sections
Norepinephrine Bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 0703-1153 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS ANDA 24 sections
Norepinephrine Bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 0703-1153 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS ANDA 24 sections
NOREPINEPHRINE BITARTRATE HUMAN PRESCRIPTION DRUG LABEL 1 0781-3755 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS ANDA 24 sections
NOREPINEPHRINE BITARTRATE HUMAN PRESCRIPTION DRUG LABEL 1 0781-3755 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS ANDA 24 sections
Norepinephrine Bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 25021-316 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 25 sections
Norepinephrine bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 36000-162 INJECTION 1 mg INTRAVENOUS ANDA 18 sections
Norepinephrine Bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 43066-997 INJECTION 1 mg INTRAVENOUS ANDA 24 sections
NOREPINEPHRINE BITARTRATE Human Prescription Drug Label 1 47335-615 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS ANDA 24 sections
LEVOPHED(R) NOREPINEPHRINE BITARTRATE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1315 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS NDA 12 sections
NOREPINEPHRINE BITARTRATE HUMAN PRESCRIPTION DRUG LABEL 1 51662-1528 INJECTION 1 mg INTRAVENOUS ANDA 16 sections
Norepinephrine Bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 51991-983 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS ANDA 25 sections
Norepinephrine Bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 52533-164 INJECTION, SOLUTION 64 ug INTRAVENOUS unapproved drug other 7 sections
Norepinephrine Bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 52533-165 INJECTION, SOLUTION 16 ug INTRAVENOUS unapproved drug other 7 sections
Norepinephrine Bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 52533-166 INJECTION, SOLUTION 32 ug INTRAVENOUS unapproved drug other 7 sections
Norepinephrine Bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 63323-940 SOLUTION 1 mg INTRAVENOUS ANDA 24 sections
Norepinephrine bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 67457-852 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS ANDA 24 sections
Norepinephrine bitartrate Human Prescription Drug Label 1 68083-437 INJECTION 1 mg INTRAVENOUS ANDA 24 sections
Norepinephrine Bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 70121-1576 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS ANDA 27 sections
Norepinephrine Bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 70121-1576 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS ANDA 27 sections
Norepinephrine bitartrate HUMAN PRESCRIPTION DRUG LABEL 1 72078-002 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS ANDA 24 sections
NOREPINEPHRINE BITARTRATE HUMAN PRESCRIPTION DRUG LABEL 1 72572-481 INJECTION, SOLUTION, CONCENTRATE 1 mg INTRAVENOUS ANDA 24 sections