norelgestromin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| steroids, progestogens | 1959 | 53016-31-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
transdermal hormonal contraceptive
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Nov. 20, 2001 | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | G03AA13 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM HORMONAL CONTRACEPTIVES FOR SYSTEMIC USE Progestogens and estrogens, fixed combinations |
| FDA CS | M0447349 | Progesterone Congeners |
| MeSH PA | D003270 | Contraceptive Agents |
| MeSH PA | D000080066 | Contraceptive Agents, Hormonal |
| MeSH PA | D012102 | Reproductive Control Agents |
| FDA EPC | N0000175602 | Progestin |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Contraception | indication | 13197004 | |
| Heart valve disorder | contraindication | 368009 | DOID:4079 |
| Hyperlipoproteinemia | contraindication | 3744001 | DOID:1168 |
| Hypercholesterolemia | contraindication | 13644009 | |
| Jaundice | contraindication | 18165001 | |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Diplopia | contraindication | 24982008 | |
| Retinal hemorrhage | contraindication | 28998008 | |
| Depressive disorder | contraindication | 35489007 | |
| Chloasma | contraindication | 36209000 | |
| Migraine | contraindication | 37796009 | DOID:6364 |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Disorder of gallbladder | contraindication | 39621005 | DOID:0060262 |
| Body fluid retention | contraindication | 43498006 | |
| Thrombosis of retinal vein | contraindication | 46085004 | |
| Chronic heart failure | contraindication | 48447003 | |
| Dementia | contraindication | 52448006 | |
| Hepatic porphyria | contraindication | 55056006 | DOID:3133 |
| Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
| Hyperlipidemia | contraindication | 55822004 | DOID:1168 |
| Thrombophlebitis | contraindication | 64156001 | DOID:3875 |
| Intermenstrual bleeding - irregular | contraindication | 64996003 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Hyperglycemia | contraindication | 80394007 | DOID:4195 |
| Epilepsy | contraindication | 84757009 | DOID:1826 |
| Breast lump | contraindication | 89164003 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Malignant neoplasm of liver | contraindication | 93870000 | DOID:3571 |
| Deep venous thrombosis | contraindication | 128053003 | |
| Seizure disorder | contraindication | 128613002 | |
| Bed-ridden | contraindication | 160685001 | |
| Liver function tests abnormal | contraindication | 166603001 | |
| Mammography abnormal | contraindication | 168750009 | |
| Angina pectoris | contraindication | 194828000 | |
| Asthma | contraindication | 195967001 | DOID:2841 |
| Cerebrovascular accident | contraindication | 230690007 | |
| Pulmonary thromboembolism | contraindication | 233935004 | |
| Thrombophilia | contraindication | 234467004 | DOID:2452 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Cholestasis of pregnancy | contraindication | 235888006 | |
| Endometrial carcinoma | contraindication | 254878006 | DOID:2871 |
| Pregnancy, function | contraindication | 289908002 | |
| Hypertriglyceridemia | contraindication | 302870006 | |
| Functional visual loss | contraindication | 313165001 | |
| Malignant tumor of ovary | contraindication | 363443007 | DOID:2394 |
| Thromboembolic disorder | contraindication | 371039008 | |
| Cardiovascular event risk | contraindication | 395112001 | |
| Disorder of coronary artery | contraindication | 414024009 | |
| Obesity | contraindication | 414916001 | DOID:9970 |
| Estrogen receptor positive tumor | contraindication | 416053008 | |
| Porphyria | contraindication | 418470004 | |
| Optic disc edema | contraindication | 423341008 | DOID:146 |
| Family history of malignant neoplasm of breast | contraindication | 429740004 | |
| Hypertensive urgency | contraindication | 443482000 | |
| Carcinoma of female breast | contraindication | 447782002 | |
| Smokes tobacco daily | contraindication | 449868002 | |
| Diabetes with Vascular Disease Complication | contraindication | ||
| Major Surgery with Prolonged Post-Operative Immobilization | contraindication | ||
| Benign Hepatic Cell Adenoma | contraindication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.81 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Progesterone receptor | Nuclear hormone receptor | AGONIST | WOMBAT-PK | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4021295 | VUID |
| N0000179766 | NUI |
| D05205 | KEGG_DRUG |
| 4021295 | VANDF |
| C1120952 | UMLSCUI |
| CHEBI:135398 | CHEBI |
| CHEMBL1200807 | ChEMBL_ID |
| DB06713 | DRUGBANK_ID |
| C449219 | MESH_SUPPLEMENTAL_RECORD_UI |
| 9568628 | PUBCHEM_CID |
| 7939 | INN_ID |
| R0TAY3X631 | UNII |
| 326374 | RXNORM |
| 16209 | MMSL |
| d04781 | MMSL |
| 009553 | NDDF |
| 385578004 | SNOMEDCT_US |
| 404867007 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| XULANE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-3340 | PATCH | 150 ug | TRANSDERMAL | ANDA | 28 sections |
| XULANE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0378-3340 | PATCH | 150 ug | TRANSDERMAL | ANDA | 28 sections |
| ZAFEMY | HUMAN PRESCRIPTION DRUG LABEL | 2 | 42291-930 | PATCH | 150 ug | TRANSDERMAL | ANDA | 31 sections |
| XULANE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50090-1683 | PATCH | 150 ug | TRANSDERMAL | ANDA | 29 sections |
| XULANE | HUMAN PRESCRIPTION DRUG LABEL | 2 | 50090-1683 | PATCH | 150 ug | TRANSDERMAL | ANDA | 29 sections |
| ZAFEMY | HUMAN PRESCRIPTION DRUG LABEL | 2 | 65162-358 | PATCH | 150 ug | TRANSDERMAL | ANDA | 32 sections |
| ZAFEMY | HUMAN PRESCRIPTION DRUG LABEL | 2 | 65162-358 | PATCH | 150 ug | TRANSDERMAL | ANDA | 32 sections |
| ZAFEMY | HUMAN PRESCRIPTION DRUG LABEL | 2 | 65162-358 | PATCH | 150 ug | TRANSDERMAL | ANDA | 32 sections |
| Norelgestromin and Ethinly Estradiol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 69238-1521 | PATCH | 150 ug | TRANSDERMAL | ANDA | 31 sections |
| Norelgestromin and Ethinly Estradiol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 69238-1521 | PATCH | 150 ug | TRANSDERMAL | ANDA | 31 sections |