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nitroxoline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| quinoline derivatives | 1954 | 4008-48-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1 | g | O |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AKT2,AKT3,AURKA,AURKB,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,ITK,JAK1,JAK2,MAP2K6,MAP3K21,MAP3K7,MAPK1,MAPK10,MAPK7,MAPK8,MAPK9,MAPKAPK2,MAPKAPK5,MARK4,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ZAP70 | 57 | |||
| kinase-selectivity-class | AXL,BRAF,CDK9,DYRK1B,GRK2,MAP2K3,MAP2K6,MAPK7,MARK4,MET,PDK4,PRKDC,STK33,SYK,TEK,TTK | 16 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01XX07 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER ANTIBACTERIALS Other antibacterials |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000892 | Anti-Infective Agents, Urinary |
| MeSH PA | D000935 | Antifungal Agents |
| CHEBI has role | CHEBI:33281 | antimicrobial agent |
| CHEBI has role | CHEBI:33282 | antibacterial agent |
| CHEBI has role | CHEBI:35441 | antiinfective agent |
| CHEBI has role | CHEBI:35718 | antifungal agent |
| CHEBI has role | CHEBI:35846 | renal agent |
Related Drugs by ATC class:
J01XX Other antibacterials 12 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.0 | acidic |
| pKa2 | 2.46 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 2 | Enzyme | Ki | 6 | CHEMBL | |||||
| Cathepsin B | Enzyme | Ki | 4.40 | CHEMBL | |||||
| Methionine aminopeptidase 2 | Enzyme | IC50 | 7.26 | CHEMBL | |||||
| Bromodomain-containing protein 4 | Nuclear other | IC50 | 6.01 | CHEMBL | |||||
| Cystathionine gamma-lyase | Enzyme | IC50 | 5.22 | CHEMBL | |||||
| Catechol O-methyltransferase | Enzyme | IC50 | 4.70 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D07245 | KEGG_DRUG |
| C0068881 | UMLSCUI |
| HNQ | PDB_CHEM_ID |
| CHEMBL1454910 | ChEMBL_ID |
| DB01422 | DRUGBANK_ID |
| 19910 | PUBCHEM_CID |
| C005308 | MESH_SUPPLEMENTAL_RECORD_UI |
| 13964 | IUPHAR_LIGAND_ID |
| 1833 | INN_ID |
| A8M33244M6 | UNII |
| 31901 | RXNORM |
| 005384 | NDDF |
| 703481003 | SNOMEDCT_US |
| 703482005 | SNOMEDCT_US |
| A8M33244M6 | INXIGHT DRUGS |
Pharmaceutical products:
None