nitroxoline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| quinoline derivatives | 1954 | 4008-48-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1 | g | O |
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01XX07 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER ANTIBACTERIALS Other antibacterials |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000892 | Anti-Infective Agents, Urinary |
| MeSH PA | D000935 | Antifungal Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.0 | acidic |
| pKa2 | 2.46 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 2 | Enzyme | Ki | 6 | CHEMBL | |||||
| Cathepsin B | Enzyme | Ki | 4.40 | CHEMBL | |||||
| Methionine aminopeptidase 2 | Enzyme | IC50 | 7.26 | CHEMBL | |||||
| Bromodomain-containing protein 4 | Unclassified | IC50 | 6.01 | CHEMBL | |||||
| Cystathionine gamma-lyase | Enzyme | IC50 | 5.22 | CHEMBL | |||||
| Catechol O-methyltransferase | Enzyme | IC50 | 4.70 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D07245 | KEGG_DRUG |
| C0068881 | UMLSCUI |
| HNQ | PDB_CHEM_ID |
| CHEMBL1454910 | ChEMBL_ID |
| DB01422 | DRUGBANK_ID |
| 19910 | PUBCHEM_CID |
| 1833 | INN_ID |
| C005308 | MESH_SUPPLEMENTAL_RECORD_UI |
| A8M33244M6 | UNII |
| 31901 | RXNORM |
| 005384 | NDDF |
| 703481003 | SNOMEDCT_US |
| 703482005 | SNOMEDCT_US |
Pharmaceutical products:
None