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2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
nitroxoline 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
quinoline derivatives
1954
4008-48-4
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
nitroxoline
nitroxolin
noxibiol
5-Nitro-8-oxychinoline
Molecular weight: 190.16
Formula: C9H6N2O3
CLOGP: 2.08
LIPINSKI: 0
HAC: 5
HDO: 1
TPSA: 78.94
ALOGS: -1.84
ROTB: 1
Drug dosage:
Dose
Unit
Route
1
g
O
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
J01XX07
ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER ANTIBACTERIALS
Other antibacterials
MeSH PA
D000890
Anti-Infective Agents
MeSH PA
D000892
Anti-Infective Agents, Urinary
MeSH PA
D000935
Antifungal Agents
Showing 1 to 4 of 4 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
7.0
acidic
pKa2
2.46
Basic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Prostaglandin G/H synthase 2
Enzyme
P35354
PGH2_HUMAN
Ki
6
CHEMBL
Cathepsin B
Enzyme
P07858
CATB_HUMAN
Ki
4.40
CHEMBL
Methionine aminopeptidase 2
Enzyme
P50579
MAP2_HUMAN
IC50
7.26
CHEMBL
Bromodomain-containing protein 4
Unclassified
O60885
BRD4_HUMAN
IC50
6.01
CHEMBL
Cystathionine gamma-lyase
Enzyme
P32929
CGL_HUMAN
IC50
5.22
CHEMBL
Catechol O-methyltransferase
Enzyme
COMT_RAT
IC50
4.70
CHEMBL
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External reference:
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entries
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ID
Source
HNQ
PDB_CHEM_ID
005384
NDDF
1833
INN_ID
19910
PUBCHEM_CID
31901
RXNORM
703481003
SNOMEDCT_US
703482005
SNOMEDCT_US
A8M33244M6
UNII
C005308
MESH_SUPPLEMENTAL_RECORD_UI
C0068881
UMLSCUI
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Pharmaceutical products:
None
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nitroxoline