Stem definition | Drug id | CAS RN |
---|---|---|
NO2 - derivatives | 1950 | 59-87-0 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
Oct. 4, 1945 | FDA | SHIRE |
None
None
None
None
Source | Code | Description |
---|---|---|
ATC | B05CA03 | BLOOD AND BLOOD FORMING ORGANS BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS IRRIGATING SOLUTIONS Antiinfectives |
ATC | D08AF01 | DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Nitrofuran derivatives |
ATC | D09AA03 | DERMATOLOGICALS MEDICATED DRESSINGS MEDICATED DRESSINGS Medicated dressings with antiinfectives |
ATC | P01CC02 | ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS ANTIPROTOZOALS AGENTS AGAINST LEISHMANIASIS AND TRYPANOSOMIASIS Nitrofuran derivatives |
ATC | S01AX04 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Other antiinfectives |
ATC | S02AA02 | SENSORY ORGANS OTOLOGICALS ANTIINFECTIVES Antiinfectives |
MeSH PA | D000890 | Anti-Infective Agents |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Klebsiella cystitis | indication | 60867007 | |
Escherichia coli urinary tract infection | indication | 301011002 | |
Staphylococcus Saprophyticus Urinary Tract Infection | indication | ||
Enterococcus Urinary Tract Infection | indication | ||
Staphylococcus Aureus Urinary Tract Infection | indication | ||
Enterobacter Cystitis | indication | ||
Prevention of Bacterial Urinary Tract Infection | off-label use | ||
Anuria | contraindication | 2472002 | DOID:2983 |
Acute hepatitis | contraindication | 37871000 | |
Vitamin B deficiency | contraindication | 47903000 | |
Fibrosis of lung | contraindication | 51615001 | DOID:3770 |
Obstructive hyperbilirubinemia | contraindication | 59848001 | |
Interstitial pneumonia | contraindication | 64667001 | |
Optic neuritis | contraindication | 66760008 | DOID:1210 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Chronic hepatitis | contraindication | 76783007 | DOID:2237 |
Oliguria | contraindication | 83128009 | |
Cholestatic hepatitis | contraindication | 95556007 | |
Anemia due to enzyme deficiency | contraindication | 111577008 | |
Deficiency of glucose-6-phosphate dehydrogenase | contraindication | 124134002 | DOID:2862 |
Cobalamin deficiency | contraindication | 190634004 | |
Impaired renal function disorder | contraindication | 197663003 | |
Drug-induced hepatitis | contraindication | 235876009 | |
Peripheral nerve disease | contraindication | 302226006 | |
Pseudomembranous enterocolitis | contraindication | 397683000 |
Species | Use | Relation |
---|---|---|
Cats | Surface bacterial infections of wounds | Indication |
Cats | Surface bacterial infections of burns | Indication |
Cats | Surface bacterial infections of skin ulcers and abscesses | Indication |
Dogs | Surface bacterial infections of wounds | Indication |
Dogs | Surface bacterial infections of burns | Indication |
Dogs | Surface bacterial infections of skin ulcers and abscesses | Indication |
Horses | Surface bacterial infections of wounds | Indication |
Horses | Surface bacterial infections of burns | Indication |
Horses | Surface bacterial infections of skin ulcers and abscesses | Indication |
Product | Applicant | Ingredients |
---|---|---|
NFZ Puffer | Neogen Corp. | 1 |
Fura Ointment | Farnam Companies Inc. | 1 |
Fura-Septin Soluble Dressing | Bimeda Animal Health Limited | 1 |
Nitrofurazone Dressing | Cronus Pharma Specialities India Private Limited | 1 |
Nitrofurazone Soluble Powder | Cronus Pharma Specialities India Private Limited | 1 |
Nitrofurazone Ointment | Bimeda Animal Health Limited | 1 |
Nitrofurazone Anesthetic Dress. | Med-Pharmex Inc. | 2 |
Fura-Zone | Squire Laboratories Inc. | 1 |
Nitrofurazone Ointment | Sparhawk Laboratories Inc. | 1 |
NFZ Wound Dressing | Neogen Corp. | 1 |
Nitrofurazone Soluble Dressing | Med-Pharmex Inc. | 1 |
Nitrofurazone Soluble Dressing | First Priority Inc. | 1 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.85 | acidic |
pKa2 | 12.47 | acidic |
pKa3 | 0.0 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Glucose-6-phosphate 1-dehydrogenase | Enzyme | WOMBAT-PK | |||||||
Sterile alpha and TIR motif-containing protein 1 | Unclassified | IC50 | 4.05 | CHEMBL | |||||
Snake venom metalloproteinase Bap1 | Enzyme | IC50 | 4.06 | CHEMBL |
ID | Source |
---|---|
4018879 | VUID |
N0000147174 | NUI |
D00862 | KEGG_DRUG |
4018879 | VANDF |
C0028157 | UMLSCUI |
CHEBI:44368 | CHEBI |
NFZ | PDB_CHEM_ID |
CHEMBL869 | ChEMBL_ID |
DB00336 | DRUGBANK_ID |
D009583 | MESH_DESCRIPTOR_UI |
5447130 | PUBCHEM_CID |
4160 | INN_ID |
12366 | IUPHAR_LIGAND_ID |
X8XI70B5Z6 | UNII |
227727 | RXNORM |
2323 | MMSL |
402 | MMSL |
5182 | MMSL |
002857 | NDDF |
332799007 | SNOMEDCT_US |
87097009 | SNOMEDCT_US |
None