nepinalone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1900 22443-11-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nepinalone hydrochloride
  • nepinalone HCl
  • nepinalone
  • Molecular weight: 271.40
  • Formula: C18H25NO
  • CLOGP: 3.72
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 20.31
  • ALOGS: -3.80
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R05DB26 RESPIRATORY SYSTEM
COUGH AND COLD PREPARATIONS
COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
Other cough suppressants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Non-productive cough indication 409596002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.22 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 7.52 SCIENTIFIC LITERATURE

External reference:

IDSource
D07396 KEGG_DRUG
22443-55-6 SECONDARY_CAS_RN
C2698448 UMLSCUI
CHEBI:135121 CHEBI
CHEMBL2105148 ChEMBL_ID
DB13445 DRUGBANK_ID
3047788 PUBCHEM_CID
6490 INN_ID
L9806LPR7G UNII

Pharmaceutical products:

None