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benproperine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 5236 | 2156-27-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
has antineoplastic activity; structure in first source
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 75 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 92 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AKT2,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK2,MAP3K7,MAPK10,MAPKAPK2,MET,NTRK2,PDK2,PDK4,PDPK1,PIM2,PRKDC,TEK,TGFBR1 | 28 | |||
| kinase-selectivity-class | AXL,PDK4 | 2 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | China Food and Drug Administration (CFDA) |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R05DB02 | RESPIRATORY SYSTEM COUGH AND COLD PREPARATIONS COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS Other cough suppressants |
| CHEBI has role | CHEBI:51177 | antitussive |
Related Drugs by ATC class:
R05DB Other cough suppressants 25 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Cough | indication | 49727002 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.92 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 3AA6IZ48YK | UNII |
| 19428-14-9 | SECONDARY_CAS_RN |
| 64238-92-2 | SECONDARY_CAS_RN |
| C0772056 | UMLSCUI |
| CHEBI:37560 | CHEBI |
| CHEMBL2105910 | ChEMBL_ID |
| 2326 | PUBCHEM_CID |
| DB13309 | DRUGBANK_ID |
| D01427 | KEGG_DRUG |
| 3118 | INN_ID |
| C477447 | MESH_SUPPLEMENTAL_RECORD_UI |
| 703110003 | SNOMEDCT_US |
| 714624000 | SNOMEDCT_US |
| 006729 | NDDF |
| 006730 | NDDF |
| 006731 | NDDF |
| 236749 | RXNORM |
Pharmaceutical products:
None