nedocromil 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antiallergics, cromoglicic acid derivatives | 1889 | 69049-73-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A pyranoquinolone derivative that inhibits activation of inflammatory cells which are associated with ASTHMA, including eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 10.40 | mg | N |
| 8 | mg | Inhal.aerosol |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.63 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Hosey CM, Chan R, Benet LZ |
| BA (Bioavailability) | 3 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.43 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 10.20 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.11 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 0.90 hours | Lombardo F, Berellini G, Obach RS |
| S (Water solubility) | 20 mg/mL | Bocci G, Oprea TI, Benet LZ |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 30, 1992 | FDA | KING PHARMS |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R01AC07 | RESPIRATORY SYSTEM NASAL PREPARATIONS DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE Antiallergic agents, excl. corticosteroids |
| ATC | R03BC03 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS Antiallergic agents, excl. corticosteroids |
| ATC | S01GX04 | SENSORY ORGANS OPHTHALMOLOGICALS DECONGESTANTS AND ANTIALLERGICS Other antiallergics |
| CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory agent |
| CHEBI has role | CHEBI:49167 | anti-asthmatic drugs |
| CHEBI has role | CHEBI:50857 | anti-allergic drugs |
| FDA PE | N0000175628 | Decreased Histamine Release |
| FDA EPC | N0000175630 | Mast Cell Stabilizer |
| MeSH PA | D018926 | Anti-Allergic Agents |
| MeSH PA | D018927 | Anti-Asthmatic Agents |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D007155 | Immunologic Factors |
| MeSH PA | D000082142 | Mast Cell Stabilizers |
| MeSH PA | D019141 | Respiratory System Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Asthma | indication | 195967001 | DOID:2841 |
| Asthma management | indication | 406162001 | |
| Allergic conjunctivitis | indication | 473460002 | DOID:11204 |
| Ocular Itching | indication | ||
| Bronchospasm Prevention | off-label use |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 1.51 | acidic |
| pKa2 | 3.02 | acidic |
| pKa3 | 4.8 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Cysteinyl leukotriene receptor 1 | GPCR | WOMBAT-PK | |||||||
| G-protein coupled receptor 35 | GPCR | AGONIST | EC50 | 6.01 | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| 4023599 | VUID |
| N0000021604 | NUI |
| D00527 | KEGG_DRUG |
| 69049-74-7 | SECONDARY_CAS_RN |
| 4020726 | VANDF |
| 4023599 | VANDF |
| C0068483 | UMLSCUI |
| CHEBI:7492 | CHEBI |
| CHEMBL746 | ChEMBL_ID |
| DB00716 | DRUGBANK_ID |
| CHEMBL915 | ChEMBL_ID |
| D017835 | MESH_DESCRIPTOR_UI |
| 50294 | PUBCHEM_CID |
| 7607 | IUPHAR_LIGAND_ID |
| 5420 | INN_ID |
| 0B535E0BN0 | UNII |
| 266663 | RXNORM |
| 5159 | MMSL |
| d03112 | MMSL |
| 003747 | NDDF |
| 003748 | NDDF |
| 108627004 | SNOMEDCT_US |
| 108629001 | SNOMEDCT_US |
| 372519004 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| ALOCRIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-8842 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | NDA | 16 sections |
| ALOCRIL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-8842 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | NDA | 16 sections |
| Nedocromil Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-066 | SOLUTION/ DROPS | 20 mg | OPHTHALMIC | ANDA | 19 sections |