nandrolone decanoate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| steroids, androgens | 1881 | 360-70-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Decanoic acid ester of nandrolone that is used as an anabolic agent to prevent or treat WASTING SYNDROME associated with severe chronic illness or HIV infection (HIV WASTING SYNDROME). It may also be used in the treatment of POSTMENOPAUSAL OSTEOPOROSIS.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 3.09 mg/mL | Bocci G, Oprea TI, Benet LZ |
| S (Water solubility) | 0.00 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Bocci G, Oprea TI, Benet LZ |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Oct. 5, 1962 | FDA | ASPEN GLOBAL INC |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug abuse | 108.47 | 97.92 | 25 | 47 | 162666 | 79581650 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D045930 | Anabolic Agents |
| MeSH PA | D006728 | Hormones |
| MeSH PA | D050071 | Bone Density Conservation Agents |
| MeSH PA | D000728 | Androgens |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
| CHEBI has role | CHEBI:50113 | androgene |
| FDA EPC | N0000175824 | Androgen |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Anemia in chronic kidney disease | indication | 707323002 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Androgen receptor | Nuclear hormone receptor | AGONIST | CHEMBL | CHEMBL | |||||
| Corticosteroid-binding globulin | Secreted | Ki | 6.14 | CHEMBL | |||||
| Sex hormone-binding globulin | Secreted | Kd | 6.30 | CHEMBL | |||||
| Solute carrier family 22 member 1 | Transporter | IC50 | 4.46 | CHEMBL | |||||
| Progesterone receptor | Transcription factor | Ki | 7.65 | CHEMBL | |||||
| Androgen receptor | Transcription factor | Ki | 8.68 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018519 | VUID |
| N0000179200 | NUI |
| D00955 | KEGG_DRUG |
| 4018519 | VANDF |
| 4019854 | VANDF |
| C0068395 | UMLSCUI |
| CHEBI:7467 | CHEBI |
| CHEBI:7466 | CHEBI |
| CHEMBL1200946 | ChEMBL_ID |
| CHEMBL757 | ChEMBL_ID |
| CHEMBL1200412 | ChEMBL_ID |
| D000077603 | MESH_DESCRIPTOR_UI |
| DB08804 | DRUGBANK_ID |
| C008580 | MESH_SUPPLEMENTAL_RECORD_UI |
| 9677 | PUBCHEM_CID |
| H45187T098 | UNII |
| DB13169 | DRUGBANK_ID |
| 217575 | RXNORM |
| 2095 | MMSL |
| 4555 | MMSL |
| 458 | MMSL |
| 5152 | MMSL |
| 5463 | MMSL |
| d00568 | MMSL |
| 001259 | NDDF |
| 001260 | NDDF |
| 126171003 | SNOMEDCT_US |
| 412253000 | SNOMEDCT_US |
| 86162003 | SNOMEDCT_US |
| C0027368 | UMLSCUI |
| 295 | INN_ID |
| 9904 | PUBCHEM_CID |
| D009277 | MESH_DESCRIPTOR_UI |
Pharmaceutical products:
None