nandrolone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
steroids, androgens 1879 434-22-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nandrolone
  • menidrabol
  • nandrolon
  • norandrostenolon
  • norandrostenolone
  • nortestonate
  • nortestosterone
  • oestrenolon
  • 19-Nortestosterone
C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less one carbon at the 19 position.
  • Molecular weight: 274.40
  • Formula: C18H26O2
  • CLOGP: 2.89
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -3.69
  • ROTB: 0

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2 mg P

ADMET properties:

PropertyValueReference
BA (Bioavailability) 2.24 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC A14AB01 ALIMENTARY TRACT AND METABOLISM
ANABOLIC AGENTS FOR SYSTEMIC USE
ANABOLIC STEROIDS
Estren derivatives
ATC S01XA11 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
FDA EPC N0000175824 Androgen
MeSH PA D045930 Anabolic Agents
MeSH PA D000728 Androgens
MeSH PA D006728 Hormones

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Anemia of chronic renal failure indication 49708008
Congenital hypoplastic anemia off-label use 88854002 DOID:1339
Hb SS disease off-label use 127040003 DOID:10923
Hypercholesterolemia contraindication 13644009
Myocardial infarction contraindication 22298006 DOID:5844
Obstruction of bile duct contraindication 30144000
Renal failure syndrome contraindication 42399005 DOID:1074
Body fluid retention contraindication 43498006
Humoral hypercalcemia of malignancy contraindication 47709007
Nephrotic syndrome contraindication 52254009 DOID:1184
Heart disease contraindication 56265001 DOID:114
Hypercalcemia contraindication 66931009 DOID:12678
Diabetes mellitus contraindication 73211009 DOID:9351
Neoplasm of prostate contraindication 126906006 DOID:10283
Decompensated cardiac failure contraindication 195111005
Disease of liver contraindication 235856003 DOID:409
Benign prostatic hyperplasia contraindication 266569009
Pregnancy, function contraindication 289908002
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Breast Carcinoma in Males contraindication

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Androgen receptor Nuclear hormone receptor AGONIST UNKNOWN IUPHAR
Sex hormone-binding globulin Secreted Kd 6.30 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 4.45 CHEMBL
Corticosteroid-binding globulin Secreted Ki 6.14 CHEMBL
Androgen receptor Transcription factor Ki 8.68 DRUG MATRIX
Progesterone receptor Transcription factor Ki 7.65 DRUG MATRIX

External reference:

IDSource
4019854 VUID
N0000147940 NUI
C0027368 UMLSCUI
D08250 KEGG_DRUG
6PG9VR430D UNII
295 INN_ID
86162003 SNOMEDCT_US
4019854 VANDF
2095 MMSL
7244 RXNORM
126171003 SNOMEDCT_US
d00568 MMSL
001259 NDDF
CHEBI:7466 CHEBI
CHEMBL757 ChEMBL_ID
6VW PDB_CHEM_ID
9904 PUBCHEM_CID
D009277 MESH_DESCRIPTOR_UI
DB13169 DRUGBANK_ID
CHEMBL2104906 ChEMBL_ID
6949 IUPHAR_LIGAND_ID

Pharmaceutical products:

None