amodiaquine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
quinoline derivatives 186 86-42-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • amodiaquine
  • amodiaquin
  • camochin
  • camoquin
  • camoquinal
  • camoquine
  • flavoquine
  • sunoquine
  • amodiaquine hydrochloride
  • amodiaquin dihydrochloride dihydrate
  • Amodiaquin dihydrochloride
  • amodiaquine HCl
  • camoquin hydrochloride
  • camoquin HCl
A 4-aminoquinoline compound with anti-inflammatory properties.
  • Molecular weight: 355.87
  • Formula: C20H22ClN3O
  • CLOGP: 5.32
  • LIPINSKI: 1
  • HAC: 4
  • HDO: 2
  • TPSA: 48.39
  • ALOGS: -4.61
  • ROTB: 6

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.50 g O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 75 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 17.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 217 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
None FDA PARKE DAVIS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC P01BA06 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Aminoquinolines
ATC P01BF03 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
ANTIMALARIALS
Artemisinin and derivatives, combinations
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent
CHEBI has role CHEBI:38068 antimalarials
CHEBI has role CHEBI:50266 Prodrugs
CHEBI has role CHEBI:88188 allergenic drug
CHEBI has role CHEBI:110725 histamine 1-methyltransferase inhibitor
CHEBI has role CHEBI:149553 anticoronaviral drug
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000962 Antimalarials
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents

Drug Use (View source of the data)

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.85 acidic
pKa2 12.0 Basic
pKa3 6.97 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.62 CHEMBL
Histamine N-methyltransferase Enzyme Ki 7.72 CHEMBL
Heparanase Enzyme Kd 4.28 CHEMBL
Amyloid beta A4 protein Unclassified IC50 5.40 CHEMBL

External reference:

IDSource
4019610 VUID
N0000147704 NUI
D02466 KEGG_DRUG
314495 RXNORM
C0002641 UMLSCUI
CHEBI:2674 CHEBI
CQA PDB_CHEM_ID
CHEMBL682 ChEMBL_ID
CHEMBL1357648 ChEMBL_ID
DB00613 DRUGBANK_ID
D000655 MESH_DESCRIPTOR_UI
2165 PUBCHEM_CID
10018 IUPHAR_LIGAND_ID
1116 INN_ID
6398-98-7 SECONDARY_CAS_RN
220236ED28 UNII
002947 NDDF
004872 NDDF
4019272 VANDF
4019610 VANDF
CHEMBL1630 ChEMBL_ID
387352008 SNOMEDCT_US
391768005 SNOMEDCT_US
64115004 SNOMEDCT_US

Pharmaceutical products:

None