mycophenolic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1860 37415-62-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mycophenolate
  • mycophenolic acid
  • mycophenolate sodium
  • mycophenolic acid monosodium salt
  • sodium mycophenolate
Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase (IMP DEHYDROGENASE). Mycophenolic acid exerts selective effects on the immune system in which it prevents the proliferation of T-CELLS, LYMPHOCYTES, and the formation of antibodies from B-CELLS. It may also inhibit recruitment of LEUKOCYTES to sites of INFLAMMATION.
  • Molecular weight: 320.34
  • Formula: C17H20O6
  • CLOGP: 2.29
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 93.06
  • ALOGS: -3.96
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
2 g O
2 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 64.22 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.77 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.33 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 9.70 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 27, 2004 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 795.31 12.13 331 34380 20621 63433690
Transplant rejection 720.03 12.13 257 34454 10523 63443788
Kidney transplant rejection 477.04 12.13 150 34561 4121 63450190
Post transplant lymphoproliferative disorder 425.03 12.13 143 34568 4888 63449423
Complications of transplanted kidney 314.21 12.13 96 34615 2390 63451921
Thrombotic microangiopathy 277.73 12.13 129 34582 10432 63443879
Polyomavirus-associated nephropathy 249.13 12.13 75 34636 1773 63452538
BK virus infection 233.37 12.13 82 34629 3197 63451114
Immunosuppressant drug level increased 217.63 12.13 80 34631 3558 63450753
Cytomegalovirus viraemia 216.69 12.13 90 34621 5559 63448752
Leukopenia 199.07 12.13 228 34483 77062 63377249
Posterior reversible encephalopathy syndrome 196.76 12.13 121 34590 17224 63437087
Delayed graft function 180.87 12.13 52 34659 1041 63453270
Epstein-Barr virus infection 177.11 12.13 87 34624 7963 63446348
Off label use 176.35 12.13 781 33930 673681 62780630
Product use in unapproved indication 175.81 12.13 335 34376 178745 63275566
COVID-19 170.08 12.13 256 34455 112847 63341464
Kidney fibrosis 168.92 12.13 56 34655 1825 63452486
Chronic allograft nephropathy 163.47 12.13 44 34667 684 63453627
Pneumocystis jirovecii pneumonia 138.00 12.13 96 34615 16818 63437493
Nephropathy toxic 136.04 12.13 77 34634 9402 63444909
Multiple organ dysfunction syndrome 133.72 12.13 160 34551 56592 63397719
Acute kidney injury 130.60 12.13 377 34334 263038 63191273
Parvovirus B19 infection 126.58 12.13 34 34677 524 63453787
Blood creatinine increased 126.58 12.13 195 34516 87649 63366662
Renal impairment 125.73 12.13 195 34516 88160 63366151
Trichodysplasia spinulosa 125.46 12.13 34 34677 543 63453768
Aspergillus infection 114.15 12.13 65 34646 8028 63446283
Graft versus host disease in skin 110.45 12.13 46 34665 2859 63451452
Graft versus host disease in gastrointestinal tract 108.87 12.13 47 34664 3194 63451117
Escherichia infection 98.48 12.13 70 34641 12684 63441627
Respiratory failure 96.68 12.13 188 34523 101670 63352641
Fatigue 91.59 12.13 221 34490 887807 62566504
Apoptosis 91.12 12.13 19 34692 87 63454224
Histoplasmosis disseminated 90.72 12.13 33 34678 1423 63452888
Epstein-Barr viraemia 90.42 12.13 30 34681 980 63453331
Pain 89.06 12.13 169 34542 740459 62713852
West Nile viral infection 88.92 12.13 24 34687 377 63453934
Arthropathy 88.12 12.13 12 34699 234780 63219531
Human herpesvirus 6 infection 86.78 12.13 39 34672 2918 63451393
Tubulointerstitial nephritis 86.58 12.13 78 34633 19825 63434486
Cryptococcosis 86.42 12.13 30 34681 1127 63453184
Renal transplant failure 86.06 12.13 27 34684 735 63453576
Lymphocele 84.20 12.13 27 34684 790 63453521
Varicella zoster virus infection 83.83 12.13 37 34674 2652 63451659
Transplant dysfunction 82.09 12.13 44 34667 4828 63449483
Klebsiella infection 80.31 12.13 53 34658 8513 63445798
Hand deformity 74.17 12.13 3 34708 159454 63294857
Nocardiosis 74.15 12.13 31 34680 1945 63452366
Liver transplant rejection 72.89 12.13 28 34683 1407 63452904
Bronchopulmonary aspergillosis 72.75 12.13 50 34661 8585 63445726
Graft loss 71.92 12.13 20 34691 353 63453958
Cat scratch disease 71.33 12.13 18 34693 214 63454097
Adenovirus infection 70.89 12.13 36 34675 3535 63450776
Post transplant distal limb syndrome 69.78 12.13 18 34693 235 63454076
Angiosarcoma 69.50 12.13 18 34693 239 63454072
Drug level increased 65.20 12.13 71 34640 22665 63431646
Disseminated cryptococcosis 64.48 12.13 19 34692 416 63453895
Haemophagocytic lymphohistiocytosis 63.46 12.13 50 34661 10577 63443734
Renal transplant 63.28 12.13 25 34686 1355 63452956
Disseminated tuberculosis 63.10 12.13 31 34680 2836 63451475
Polyomavirus viraemia 62.52 12.13 21 34690 713 63453598
Human ehrlichiosis 61.18 12.13 15 34696 157 63454154
Encephalitis viral 61.08 12.13 26 34685 1706 63452605
Histoplasmosis 61.06 12.13 27 34684 1944 63452367
Blastomycosis 60.82 12.13 17 34694 306 63454005
Pancreatitis haemorrhagic 60.67 12.13 19 34692 514 63453797
Proteinuria 60.59 12.13 63 34648 19082 63435229
Aplasia pure red cell 60.50 12.13 35 34676 4452 63449859
Cytomegalovirus colitis 59.33 12.13 28 34683 2344 63451967
Brain abscess 59.20 12.13 27 34684 2091 63452220
Focal segmental glomerulosclerosis 58.36 12.13 24 34687 1444 63452867
Diffuse large B-cell lymphoma 56.86 12.13 39 34672 6673 63447638
Contraindicated product administered 56.70 12.13 24 34687 217624 63236687
Hypersensitivity 55.62 12.13 47 34664 292638 63161673
Wound 55.32 12.13 11 34700 163252 63291059
Drug hypersensitivity 54.17 12.13 54 34657 310633 63143678
JC virus infection 53.74 12.13 25 34686 2026 63452285
Infusion related reaction 53.69 12.13 34 34677 245487 63208824
Rash 53.42 12.13 145 34566 560726 62893585
Arthralgia 52.99 12.13 149 34562 569561 62884750
Phaeohyphomycosis 52.56 12.13 15 34696 292 63454019
Renal tubular necrosis 52.54 12.13 47 34664 11831 63442480
Graft versus host disease 51.93 12.13 37 34674 6726 63447585
Urinary tract infection 51.80 12.13 283 34428 264401 63189910
Joint swelling 51.56 12.13 62 34649 327604 63126707
Human polyomavirus infection 51.49 12.13 15 34696 315 63453996
Discomfort 51.31 12.13 14 34697 167360 63286951
Chromoblastomycosis 51.03 12.13 10 34701 31 63454280
Angiosarcoma metastatic 50.27 12.13 11 34700 66 63454245
Renal tubular atrophy 49.89 12.13 18 34693 758 63453553
Emphysematous pyelonephritis 49.53 12.13 14 34697 263 63454048
Ureaplasma infection 49.09 12.13 17 34694 634 63453677
COVID-19 pneumonia 49.04 12.13 49 34662 14160 63440151
Acute respiratory distress syndrome 48.40 12.13 62 34649 23472 63430839
Pancreas transplant rejection 47.68 12.13 12 34699 141 63454170
Diabetes mellitus 46.93 12.13 98 34613 55712 63398599
Haemolytic uraemic syndrome 46.12 12.13 24 34687 2479 63451832
Immunosuppressant drug level decreased 46.11 12.13 18 34693 945 63453366
Lupus nephritis 46.04 12.13 25 34686 2814 63451497
Protein urine present 45.89 12.13 33 34678 6087 63448224
Cerebral toxoplasmosis 45.84 12.13 18 34693 960 63453351
Interstitial lung disease 45.54 12.13 103 34608 61805 63392506
Central nervous system lymphoma 44.68 12.13 20 34691 1482 63452829
Swelling 44.49 12.13 51 34660 275327 63178984
Calciphylaxis 44.20 12.13 25 34686 3047 63451264
Fall 43.99 12.13 93 34618 392241 63062070
Injection site pain 43.44 12.13 9 34702 129791 63324520
Hospitalisation 43.20 12.13 123 34588 84958 63369353
Distributive shock 43.02 12.13 19 34692 1364 63452947
Diarrhoea 42.19 12.13 585 34126 714781 62739530
Hypogammaglobulinaemia 41.30 12.13 33 34678 7122 63447189
Toxoplasmosis 41.26 12.13 19 34692 1504 63452807
Central nervous system lupus 41.00 12.13 14 34697 500 63453811
Dizziness 40.99 12.13 111 34600 429814 63024497
Pemphigus 40.76 12.13 25 34686 183701 63270610
Synovitis 40.69 12.13 26 34685 186892 63267419
Viraemia 40.68 12.13 18 34693 1298 63453013
Pericarditis 40.33 12.13 11 34700 131568 63322743
Cystitis haemorrhagic 39.84 12.13 26 34685 4097 63450214
Atypical haemolytic uraemic syndrome 39.70 12.13 15 34696 720 63453591
Blister 39.52 12.13 11 34700 129803 63324508
Abdominal discomfort 39.47 12.13 72 34639 320813 63133498
Drug interaction 38.92 12.13 236 34475 228895 63225416
Renal failure 38.09 12.13 146 34565 117506 63336805
Biopsy lung abnormal 37.36 12.13 10 34701 152 63454159
Enterococcal infection 36.60 12.13 32 34679 7816 63446495
Stomatitis 36.59 12.13 15 34696 138710 63315601
Bacillary angiomatosis 36.22 12.13 9 34702 100 63454211
Alopecia 36.18 12.13 82 34629 337454 63116857
Acanthamoeba infection 36.01 12.13 8 34703 52 63454259
Disseminated mucormycosis 35.78 12.13 10 34701 180 63454131
Infection reactivation 35.78 12.13 16 34695 1183 63453128
Herpes simplex hepatitis 35.76 12.13 12 34699 406 63453905
Pseudomonas infection 35.66 12.13 37 34674 11176 63443135
Transplantation associated food allergy 35.65 12.13 7 34704 22 63454289
Oedematous kidney 35.36 12.13 9 34702 111 63454200
Contusion 35.30 12.13 19 34692 150025 63304286
Rheumatoid arthritis 34.86 12.13 53 34658 253766 63200545
Papilloma viral infection 34.62 12.13 17 34694 1553 63452758
Lymphopenia 34.15 12.13 46 34665 18281 63436030
Nephropathy 33.97 12.13 28 34683 6313 63447998
Pruritus 33.93 12.13 94 34617 361359 63092952
Agranulocytosis 33.67 12.13 54 34657 25080 63429231
Acute graft versus host disease 33.48 12.13 24 34687 4404 63449907
Alveolar proteinosis 33.31 12.13 11 34700 354 63453957
Gastroenteritis norovirus 32.95 12.13 18 34693 2050 63452261
Fibromyalgia 32.94 12.13 3 34708 80417 63373894
Sepsis 32.84 12.13 168 34543 152955 63301356
Complications of transplanted lung 32.34 12.13 10 34701 259 63454052
Therapeutic product effect decreased 32.04 12.13 35 34676 193152 63261159
Helicobacter infection 31.95 12.13 6 34705 92779 63361532
Oedematous pancreatitis 31.90 12.13 12 34699 569 63453742
Chronic kidney disease 31.69 12.13 74 34637 45324 63408987
Genital herpes simplex 31.24 12.13 10 34701 291 63454020
Osteoarthritis 31.10 12.13 7 34704 95336 63358975
Hepatic enzyme increased 31.03 12.13 39 34672 202289 63252022
Cytomegalovirus nephritis 30.77 12.13 6 34705 18 63454293
End stage renal disease 30.63 12.13 27 34684 6666 63447645
Perinephric abscess 30.41 12.13 9 34702 200 63454111
Rhodococcus infection 30.30 12.13 8 34703 115 63454196
Oesophageal stenosis 30.11 12.13 20 34691 3246 63451065
Depression 30.01 12.13 38 34673 196454 63257857
Hepatitis E 29.96 12.13 15 34696 1429 63452882
Biloma 29.81 12.13 7 34704 60 63454251
Malacoplakia vesicae 29.81 12.13 7 34704 60 63454251
Malacoplakia gastrointestinal 29.60 12.13 7 34704 62 63454249
Insomnia 29.50 12.13 45 34666 215207 63239104
Injection site erythema 29.46 12.13 5 34706 83169 63371142
Renal tubular injury 29.40 12.13 11 34700 514 63453797
Anxiety 29.32 12.13 46 34665 217495 63236816
Wheezing 29.28 12.13 8 34703 95587 63358724
Irritable bowel syndrome 29.09 12.13 5 34706 82407 63371904
Malignant neoplasm progression 28.95 12.13 5 34706 82116 63372195
Neutropenia 28.90 12.13 179 34532 174826 63279485
Scedosporium infection 28.65 12.13 11 34700 552 63453759
Transplant failure 28.64 12.13 15 34696 1570 63452741
Escherichia urinary tract infection 28.60 12.13 34 34677 11928 63442383
Vaccination failure 28.53 12.13 12 34699 764 63453547
Urinary tract candidiasis 28.06 12.13 11 34700 584 63453727
Mycobacterium haemophilum infection 28.02 12.13 6 34705 32 63454279
Haemolytic anaemia 27.95 12.13 31 34680 10094 63444217
Nasopharyngitis 27.85 12.13 61 34650 254196 63200115
Pathogen resistance 27.67 12.13 25 34686 6373 63447938
Donor specific antibody present 27.46 12.13 8 34703 168 63454143
Locked-in syndrome 27.43 12.13 10 34701 434 63453877
Microsporidia infection 27.30 12.13 9 34702 288 63454023
Intentional overdose 27.30 12.13 4 34707 74148 63380163
Acute graft versus host disease in intestine 27.25 12.13 15 34696 1734 63452577
Pyrexia 26.92 12.13 383 34328 470095 62984216
Oesophageal ulcer 26.54 12.13 21 34690 4469 63449842
Confusional state 26.48 12.13 56 34655 236324 63217987
Progressive multifocal leukoencephalopathy 26.40 12.13 34 34677 12937 63441374
Philadelphia positive chronic myeloid leukaemia 26.38 12.13 6 34705 44 63454267
Mycobacterium avium complex infection 26.29 12.13 18 34693 3070 63451241
Oesophageal candidiasis 26.23 12.13 23 34688 5640 63448671
Epstein-Barr virus associated lymphoproliferative disorder 26.14 12.13 15 34696 1879 63452432
Pyelonephritis acute 25.92 12.13 21 34690 4620 63449691
Bacterial pyelonephritis 25.80 12.13 9 34702 343 63453968
Disease recurrence 25.66 12.13 51 34660 27979 63426332
Bacteraemia 25.64 12.13 39 34672 17309 63437002
Disseminated varicella zoster vaccine virus infection 25.49 12.13 6 34705 52 63454259
Cytomegalovirus hepatitis 25.46 12.13 9 34702 357 63453954
Hepatic angiosarcoma 25.39 12.13 5 34706 16 63454295
Ureteral necrosis 25.39 12.13 6 34705 53 63454258
Psoriasis 25.31 12.13 8 34703 86949 63367362
Tuberculosis gastrointestinal 25.29 12.13 9 34702 364 63453947
Diabetic macroangiopathy 25.04 12.13 7 34704 126 63454185
Pyelonephritis 24.92 12.13 39 34672 17739 63436572
Human herpesvirus 6 encephalitis 24.79 12.13 8 34703 239 63454072
Forced vital capacity decreased 24.74 12.13 12 34699 1067 63453244
Obliterative bronchiolitis 24.73 12.13 15 34696 2080 63452231
Renal-limited thrombotic microangiopathy 24.72 12.13 6 34705 60 63454251
Mastitis bacterial 24.54 12.13 6 34705 62 63454249
Graft complication 24.51 12.13 8 34703 248 63454063
Cytomegalovirus infection reactivation 24.42 12.13 19 34692 3944 63450367
Butterfly rash 24.36 12.13 14 34697 1759 63452552
Pain in extremity 24.34 12.13 96 34615 331390 63122921
Urinary fistula 24.33 12.13 5 34706 21 63454290
Pyelonephritis fungal 24.30 12.13 7 34704 141 63454170
Cytomegalovirus chorioretinitis 24.21 12.13 14 34697 1779 63452532
Escherichia pyelonephritis 24.10 12.13 9 34702 418 63453893
Incision site pain 23.94 12.13 12 34699 1146 63453165
Suicidal ideation 23.85 12.13 3 34708 62418 63391893
Back pain 23.80 12.13 70 34641 264075 63190236
Drug resistance 23.79 12.13 44 34667 22889 63431422
Hyperammonaemia 23.73 12.13 21 34690 5211 63449100
Septic shock 23.48 12.13 85 34626 66544 63387767
Lung transplant rejection 23.36 12.13 11 34700 916 63453395
Clostridium difficile colitis 23.30 12.13 41 34670 20528 63433783
Vascular hyalinosis 23.14 12.13 5 34706 28 63454283
Coccidioidomycosis 22.95 12.13 11 34700 953 63453358
Candida infection 22.91 12.13 49 34662 28302 63426009
Liver abscess 22.81 12.13 16 34695 2838 63451473
Herpes simplex oesophagitis 22.76 12.13 7 34704 178 63454133
Mucormycosis 22.72 12.13 16 34695 2855 63451456
Polyomavirus test positive 22.68 12.13 6 34705 87 63454224
Cytomegalovirus syndrome 22.68 12.13 6 34705 87 63454224
Necrotising herpetic retinopathy 22.49 12.13 6 34705 90 63454221
Balance disorder 22.46 12.13 9 34702 84413 63369898
Anogenital warts 22.36 12.13 9 34702 512 63453799
Colon injury 22.36 12.13 7 34704 189 63454122
Mobility decreased 22.32 12.13 20 34691 121139 63333172
Constipation 22.21 12.13 57 34654 224886 63229425
Concomitant disease progression 21.96 12.13 14 34697 2120 63452191
Pancytopenia 21.93 12.13 108 34603 96825 63357486
Lower respiratory tract infection 21.89 12.13 24 34687 132283 63322028
Mycobacterial infection 21.65 12.13 13 34698 1770 63452541
Disseminated cytomegaloviral infection 21.63 12.13 7 34704 211 63454100
Lung transplant 21.49 12.13 16 34695 3112 63451199
New onset diabetes after transplantation 21.47 12.13 6 34705 108 63454203
Enterobacter infection 21.41 12.13 14 34697 2213 63452098
Urinoma 21.38 12.13 5 34706 42 63454269
Hypoaesthesia 21.38 12.13 37 34674 168356 63285955
Musculoskeletal stiffness 21.29 12.13 43 34668 184575 63269736
Orthobunyavirus test positive 21.04 12.13 4 34707 10 63454301
Systemic candida 20.97 12.13 16 34695 3229 63451082
Heart transplant rejection 20.92 12.13 9 34702 606 63453705
Glomerulosclerosis 20.92 12.13 8 34703 397 63453914
Epidermodysplasia verruciformis 20.60 12.13 6 34705 126 63454185
Herpes simplex 20.59 12.13 24 34687 8247 63446064
Dermatomyositis 20.54 12.13 15 34696 2833 63451478
Systemic bacterial infection 20.51 12.13 4 34707 12 63454299
Dermatitis papillaris capillitii 20.51 12.13 4 34707 12 63454299
Human herpesvirus 8 infection 20.47 12.13 7 34704 251 63454060
Disseminated mycobacterium avium complex infection 20.46 12.13 6 34705 129 63454182
Pneumopericardium 20.42 12.13 5 34706 52 63454259
Skin hypertrophy 20.34 12.13 16 34695 3375 63450936
Hydronephrosis 20.23 12.13 27 34684 10635 63443676
Acid base balance abnormal 20.19 12.13 7 34704 262 63454049
Mucinous adenocarcinoma of appendix 20.04 12.13 4 34707 14 63454297
Knee arthroplasty 19.78 12.13 3 34708 54203 63400108
Klebsiella bacteraemia 19.77 12.13 12 34699 1666 63452645
Sinusitis 19.74 12.13 61 34650 226592 63227719
Urticaria 19.65 12.13 38 34673 165764 63288547
Hyperamylasaemia 19.60 12.13 8 34703 472 63453839
Plasmapheresis 19.58 12.13 7 34704 287 63454024
Nosocomial infection 19.49 12.13 12 34699 1709 63452602
Renal lymphocele 19.40 12.13 5 34706 65 63454246
Meningitis cryptococcal 19.25 12.13 11 34700 1366 63452945
Encephalitis 19.21 12.13 24 34687 8856 63445455
Pneumonia fungal 19.17 12.13 19 34692 5436 63448875
Mycobacterium chelonae infection 19.10 12.13 8 34703 504 63453807
Pneumonia cytomegaloviral 19.07 12.13 13 34698 2201 63452110
Disseminated intravascular coagulation 19.07 12.13 36 34675 19015 63435296
Mouth ulceration 19.04 12.13 50 34661 32934 63421377
Epstein-Barr virus associated lymphoma 19.01 12.13 8 34703 510 63453801
Total lung capacity abnormal 18.86 12.13 5 34706 73 63454238
Peliosis hepatis 18.86 12.13 5 34706 73 63454238
Malacoplakia 18.76 12.13 6 34705 174 63454137
Death 18.75 12.13 298 34413 374083 63080228
Therapy cessation 18.43 12.13 47 34664 30410 63423901
Encephalitis cytomegalovirus 18.40 12.13 8 34703 553 63453758
American trypanosomiasis 18.38 12.13 5 34706 81 63454230
Pneumonia 18.36 12.13 351 34360 456416 62997895
Systemic lupus erythematosus 18.35 12.13 56 34655 208862 63245449
Infective scleritis 18.28 12.13 4 34707 24 63454287
Rhinovirus infection 18.23 12.13 17 34694 4512 63449799
Smooth muscle cell neoplasm 18.23 12.13 9 34702 832 63453479
Asthma 18.11 12.13 26 34685 127535 63326776
Drug level decreased 18.10 12.13 22 34689 7897 63446414
Acute motor axonal neuropathy 18.00 12.13 4 34707 26 63454285
Influenza like illness 17.98 12.13 7 34704 66817 63387494
Infectious pleural effusion 17.83 12.13 11 34700 1572 63452739
Pulmonary alveolar haemorrhage 17.79 12.13 17 34694 4651 63449660
Gait disturbance 17.63 12.13 47 34664 183131 63271180
Injury 17.63 12.13 9 34702 73238 63381073
Cytomegalovirus test positive 17.59 12.13 14 34697 3004 63451307
Strongyloidiasis 17.53 12.13 10 34701 1238 63453073
Angiocentric lymphoma 17.50 12.13 8 34703 623 63453688
Gastrointestinal mucormycosis 17.22 12.13 6 34705 228 63454083
Red blood cells urine positive 17.16 12.13 14 34697 3112 63451199
Mycobacterium abscessus infection 17.11 12.13 8 34703 656 63453655
Steroid diabetes 17.10 12.13 10 34701 1298 63453013
Renal disorder 17.05 12.13 48 34663 32926 63421385
Pancreatitis necrotising 17.04 12.13 11 34700 1701 63452610
Nephrotic syndrome 17.02 12.13 18 34693 5558 63448753
Hypertriglyceridaemia 17.00 12.13 19 34692 6240 63448071
Haemoperitoneum 16.59 12.13 13 34698 2728 63451583
Secondary immunodeficiency 16.58 12.13 10 34701 1373 63452938
Fanconi syndrome 16.52 12.13 10 34701 1382 63452929
Glomerulonephritis 16.51 12.13 11 34700 1795 63452516
Joint tuberculosis 16.49 12.13 5 34706 121 63454190
Cardiac murmur functional 16.48 12.13 4 34707 40 63454271
B-cell lymphoma 16.47 12.13 14 34697 3291 63451020
Urinary tract infection bacterial 16.46 12.13 17 34694 5105 63449206
Decreased appetite 16.39 12.13 76 34635 250976 63203335
Metastatic squamous cell carcinoma 16.36 12.13 6 34705 265 63454046
Neutrophil count increased 16.26 12.13 31 34680 16496 63437815
Pulmonary function test decreased 16.24 12.13 15 34696 3932 63450379
Asthenia 16.24 12.13 133 34578 383471 63070840
Orbital apex syndrome 16.22 12.13 4 34707 43 63454268
Brain natriuretic peptide increased 16.21 12.13 17 34694 5196 63449115
Paraesthesia 16.09 12.13 39 34672 156927 63297384
Acute pulmonary histoplasmosis 15.94 12.13 5 34706 136 63454175
Malaise 15.93 12.13 148 34563 415806 63038505
Biopsy kidney 15.87 12.13 5 34706 138 63454173
Transplant 15.71 12.13 8 34703 790 63453521
Cytomegalovirus gastrointestinal infection 15.57 12.13 6 34705 304 63454007
Heart transplant 15.46 12.13 7 34704 533 63453778
Dry mouth 15.39 12.13 12 34699 77851 63376460
Meningitis histoplasma 15.38 12.13 3 34708 9 63454302
Purulent pericarditis 15.38 12.13 4 34707 54 63454257
Bacteroides bacteraemia 15.18 12.13 4 34707 57 63454254
Chronic graft versus host disease 15.18 12.13 13 34698 3089 63451222
Eye infection viral 15.17 12.13 5 34706 160 63454151
Type 2 diabetes mellitus 15.14 12.13 8 34703 63860 63390451
Pseudomonal bacteraemia 15.08 12.13 10 34701 1618 63452693
Renal necrosis 14.99 12.13 4 34707 60 63454251
Urosepsis 14.95 12.13 32 34679 18492 63435819
Medication error 14.88 12.13 5 34706 52279 63402032
Fungal sepsis 14.75 12.13 9 34702 1261 63453050
Colitis 14.70 12.13 59 34652 48469 63405842
Therapy interrupted 14.63 12.13 45 34666 32410 63421901
Microangiopathic haemolytic anaemia 14.50 12.13 7 34704 616 63453695
Anaemia 14.46 12.13 233 34478 293197 63161114
Renal haemorrhage 14.44 12.13 8 34703 936 63453375
Ureteric stenosis 14.42 12.13 7 34704 624 63453687
Graft versus host disease in eye 14.42 12.13 4 34707 70 63454241
Graft versus host disease in lung 14.36 12.13 6 34705 376 63453935
Bacterial sepsis 14.31 12.13 14 34697 3944 63450367
Mucocutaneous leishmaniasis 14.27 12.13 6 34705 382 63453929
Drug effective for unapproved indication 14.26 12.13 13 34698 3351 63450960
Bacterial colitis 14.26 12.13 4 34707 73 63454238
Graft versus host disease in liver 14.15 12.13 7 34704 650 63453661
Microtia 14.08 12.13 6 34705 395 63453916
Therapy change 14.07 12.13 17 34694 6064 63448247
Candida sepsis 14.07 12.13 9 34702 1371 63452940
Gastroenteritis cryptosporidial 13.96 12.13 4 34707 79 63454232
Necrotising retinitis 13.92 12.13 6 34705 406 63453905
Suicide attempt 13.90 12.13 8 34703 60910 63393401
Intentional product misuse 13.90 12.13 8 34703 60909 63393402
Scleroderma 13.85 12.13 16 34695 5446 63448865
Injection site bruising 13.82 12.13 3 34708 41907 63412404
Peripheral swelling 13.77 12.13 87 34624 265855 63188456
Lung diffusion test decreased 13.75 12.13 7 34704 691 63453620
Dry skin 13.67 12.13 7 34704 56880 63397431
Leiomyosarcoma 13.65 12.13 5 34706 220 63454091
Histoplasmosis cutaneous 13.57 12.13 3 34708 19 63454292
Impaired healing 13.50 12.13 22 34689 102520 63351791
Normocytic anaemia 13.50 12.13 10 34701 1930 63452381
Muscle disorder 13.35 12.13 15 34696 4954 63449357
Neutrophil Pelger-Huet anomaly present 13.31 12.13 4 34707 94 63454217
Brain herniation 13.28 12.13 13 34698 3664 63450647
Coloboma 13.27 12.13 4 34707 95 63454216
Chronic obstructive pulmonary disease 13.25 12.13 9 34702 62677 63391634
Sleep disorder due to general medical condition, insomnia type 13.20 12.13 6 34705 52211 63402100
Wound complication 13.07 12.13 13 34698 3734 63450577
Bone marrow granuloma 12.96 12.13 3 34708 24 63454287
Sterile pyuria 12.96 12.13 3 34708 24 63454287
Renal abscess 12.93 12.13 7 34704 783 63453528
Nephrostomy 12.92 12.13 4 34707 104 63454207
Anuria 12.92 12.13 24 34687 12527 63441784
Muscle spasms 12.91 12.13 43 34668 156107 63298204
Renal graft infection 12.91 12.13 5 34706 257 63454054
Lymphoproliferative disorder 12.89 12.13 12 34699 3178 63451133
Azotaemia 12.88 12.13 14 34697 4457 63449854
Extremity necrosis 12.79 12.13 9 34702 1604 63452707
Hepatic cyst infection 12.78 12.13 4 34707 108 63454203
Anorexia nervosa 12.76 12.13 5 34706 265 63454046
Cervicitis 12.72 12.13 6 34705 502 63453809
Systemic mycosis 12.68 12.13 8 34703 1189 63453122
Neuropathy peripheral 12.65 12.13 27 34684 113640 63340671
Mycoplasma infection 12.65 12.13 6 34705 508 63453803
Myocardial infarction 12.63 12.13 22 34689 99871 63354440
Pancreatitis acute 12.56 12.13 38 34673 27128 63427183
Drug ineffective for unapproved indication 12.46 12.13 44 34667 34019 63420292
Hyperuricaemia 12.40 12.13 15 34696 5355 63448956
Typhoid fever 12.27 12.13 3 34708 31 63454280
Sebaceous carcinoma 12.27 12.13 3 34708 31 63454280
Squamous cell carcinoma 12.19 12.13 19 34692 8613 63445698

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Kidney transplant rejection 706.11 12.77 283 41172 7214 34908262
Transplant rejection 682.89 12.77 303 41152 10008 34905468
Cytomegalovirus infection 622.57 12.77 387 41068 25748 34889728
Complications of transplanted kidney 493.65 12.77 191 41264 4418 34911058
Post transplant lymphoproliferative disorder 442.32 12.77 195 41260 6333 34909143
Polyomavirus-associated nephropathy 358.00 12.77 144 41311 3700 34911776
COVID-19 323.47 12.77 428 41027 77122 34838354
Immunosuppressant drug level increased 301.20 12.77 146 41309 5909 34909567
BK virus infection 272.35 12.77 134 41321 5604 34909872
Transplant dysfunction 232.12 12.77 95 41360 2554 34912922
Renal transplant failure 229.85 12.77 75 41380 1031 34914445
Thrombotic microangiopathy 207.44 12.77 139 41316 10491 34904985
Blood creatinine increased 201.74 12.77 385 41070 94591 34820885
Hepatitis E 200.65 12.77 80 41375 2006 34913470
Delayed graft function 175.53 12.77 74 41381 2147 34913329
Leukopenia 170.96 12.77 284 41171 62572 34852904
Cytomegalovirus viraemia 161.63 12.77 104 41351 7326 34908150
West Nile viral infection 148.55 12.77 49 41406 698 34914778
Transplant failure 145.21 12.77 75 41380 3478 34911998
Aspergillus infection 141.70 12.77 117 41338 12137 34903339
Cryptococcosis 140.75 12.77 65 41390 2354 34913122
JC virus infection 140.04 12.77 63 41392 2145 34913331
Parvovirus B19 infection 138.19 12.77 48 41407 807 34914669
Chronic allograft nephropathy 134.23 12.77 52 41403 1205 34914271
Nephropathy toxic 124.73 12.77 110 41345 12478 34902998
Drug level increased 124.34 12.77 142 41313 21954 34893522
Nocardiosis 124.02 12.77 70 41385 3881 34911595
Mucormycosis 123.91 12.77 81 41374 5861 34909615
Product use in unapproved indication 121.64 12.77 360 41095 117139 34798337
Epstein-Barr virus infection 121.32 12.77 88 41367 7540 34907936
Renal tubular atrophy 119.90 12.77 47 41408 1125 34914351
Incision site pain 115.16 12.77 52 41403 1786 34913690
Kidney fibrosis 108.60 12.77 53 41402 2175 34913301
Bronchopulmonary aspergillosis 104.93 12.77 107 41348 14552 34900924
Fall 99.07 12.77 59 41396 202826 34712650
Pulmonary nocardiosis 98.51 12.77 38 41417 870 34914606
Malacoplakia 94.67 12.77 31 41424 431 34915045
Renal artery stenosis 93.18 12.77 48 41407 2213 34913263
Phaeohyphomycosis 93.17 12.77 36 41419 828 34914648
Strongyloidiasis 85.00 12.77 48 41407 2663 34912813
Acute kidney injury 84.44 12.77 634 40821 304354 34611122
Pseudomonas infection 84.32 12.77 88 41367 12294 34903182
Renal impairment 83.33 12.77 274 41181 94239 34821237
Focal segmental glomerulosclerosis 80.61 12.77 42 41413 1983 34913493
Histoplasmosis disseminated 80.47 12.77 37 41418 1326 34914150
Proteinuria 77.69 12.77 103 41352 18539 34896937
Rash 77.62 12.77 90 41365 222662 34692814
Polyomavirus viraemia 76.39 12.77 32 41423 913 34914563
COVID-19 pneumonia 75.77 12.77 97 41358 16870 34898606
Klebsiella infection 75.56 12.77 70 41385 8461 34907015
Alternaria infection 74.42 12.77 25 41430 378 34915098
Fatigue 74.34 12.77 211 41244 370442 34545034
Enterococcal infection 74.12 12.77 72 41383 9234 34906242
Pain 73.14 12.77 81 41374 204594 34710882
Lymphocyte count decreased 72.13 12.77 110 41345 22512 34892964
Lymphocele 71.34 12.77 34 41421 1323 34914153
Adenovirus infection 71.01 12.77 55 41400 5202 34910274
Apoptosis 70.02 12.77 24 41431 387 34915089
Diffuse large B-cell lymphoma 68.25 12.77 62 41393 7308 34908168
Pneumonia cryptococcal 67.72 12.77 29 41426 875 34914601
Pneumonia cytomegaloviral 67.03 12.77 43 41412 3011 34912465
Pruritus 66.87 12.77 43 41412 141938 34773538
Septic shock 66.67 12.77 212 41243 71622 34843854
Malignant neoplasm progression 66.56 12.77 12 41443 88034 34827442
Hydronephrosis 65.96 12.77 71 41384 10275 34905201
Off label use 65.18 12.77 771 40684 418753 34496723
Cystitis haemorrhagic 65.17 12.77 54 41401 5625 34909851
Liver transplant rejection 65.04 12.77 37 41418 2082 34913394
Histoplasmosis 64.80 12.77 33 41422 1485 34913991
Brain abscess 63.69 12.77 42 41413 3083 34912393
Graft loss 61.80 12.77 27 41428 856 34914620
Haemophagocytic lymphohistiocytosis 60.83 12.77 76 41379 12897 34902579
Cytomegalovirus colitis 60.62 12.77 39 41416 2745 34912731
Intraductal papillary mucinous neoplasm 60.22 12.77 23 41432 512 34914964
Arthralgia 59.95 12.77 68 41387 169973 34745503
Blastomycosis 59.70 12.77 22 41433 442 34915034
Acinetobacter infection 59.69 12.77 29 41426 1178 34914298
Aplasia pure red cell 59.57 12.77 53 41402 6079 34909397
Posterior reversible encephalopathy syndrome 59.44 12.77 66 41389 9888 34905588
Constipation 58.57 12.77 46 41409 136936 34778540
Depression 56.84 12.77 22 41433 97076 34818400
Red blood cells urine positive 56.64 12.77 32 41423 1777 34913699
Encephalitis viral 56.59 12.77 28 41427 1184 34914292
Pneumocystis jirovecii pneumonia 56.12 12.77 91 41364 19619 34895857
Renal tubular necrosis 55.37 12.77 80 41375 15600 34899876
Progressive multifocal leukoencephalopathy 55.33 12.77 63 41392 9701 34905775
Cryptosporidiosis infection 55.09 12.77 21 41434 465 34915011
Rectal prolapse 54.84 12.77 21 41434 471 34915005
Infection reactivation 53.77 12.77 29 41426 1469 34914007
Dizziness 53.45 12.77 112 41343 218409 34697067
Gastroenteritis norovirus 53.27 12.77 29 41426 1497 34913979
Disseminated cryptococcosis 53.04 12.77 28 41427 1358 34914118
Renal cyst haemorrhage 52.87 12.77 22 41433 617 34914859
Protein urine present 52.41 12.77 46 41409 5182 34910294
Basal cell carcinoma 52.26 12.77 88 41367 19570 34895906
Scedosporium infection 52.25 12.77 24 41431 858 34914618
Graft versus host disease in skin 50.71 12.77 40 41415 3885 34911591
Rhodococcus infection 50.20 12.77 16 41439 203 34915273
Urinary tract infection 50.07 12.77 215 41240 83866 34831610
Lymphopenia 50.06 12.77 78 41377 16257 34899219
Diabetes mellitus 49.71 12.77 145 41310 46728 34868748
Acute respiratory distress syndrome 48.63 12.77 100 41355 25869 34889607
Dermatophytosis 48.63 12.77 16 41439 226 34915250
Graft versus host disease in gastrointestinal tract 48.59 12.77 38 41417 3645 34911831
Syncope 48.34 12.77 24 41431 91427 34824049
Squamous cell carcinoma of skin 48.25 12.77 62 41393 10819 34904657
Acanthamoeba infection 47.12 12.77 18 41437 401 34915075
Anxiety 46.94 12.77 30 41425 99398 34816078
Renal tubular injury 46.76 12.77 23 41432 960 34914516
Hyperhidrosis 46.24 12.77 16 41439 75676 34839800
Neutrophil count increased 45.90 12.77 77 41378 17069 34898407
Ureteric stenosis 45.69 12.77 24 41431 1152 34914324
Graft versus host disease in lung 44.62 12.77 19 41436 565 34914911
Drug hypersensitivity 44.30 12.77 20 41435 80509 34834967
Varicella zoster virus infection 43.57 12.77 27 41428 1779 34913697
Meningitis cryptococcal 43.47 12.77 30 41425 2374 34913102
Graft versus host disease 43.42 12.77 58 41397 10511 34904965
Escherichia infection 43.04 12.77 51 41404 8194 34907282
Dyspnoea 42.73 12.77 267 41188 376515 34538961
Donor specific antibody present 41.36 12.77 12 41443 108 34915368
Escherichia urinary tract infection 41.28 12.77 34 41421 3512 34911964
Trichodysplasia spinulosa 40.00 12.77 14 41441 241 34915235
American trypanosomiasis 39.89 12.77 14 41441 243 34915233
SARS-CoV-2 antibody test positive 39.87 12.77 16 41439 408 34915068
Vena cava injury 39.65 12.77 15 41440 325 34915151
Actinic keratosis 39.53 12.77 37 41418 4530 34910946
Blood urea increased 39.23 12.77 101 41354 30263 34885213
Chronic obstructive pulmonary disease 38.43 12.77 6 41449 48912 34866564
Drug interaction 38.37 12.77 423 41032 225523 34689953
Febrile neutropenia 37.93 12.77 65 41390 136784 34778692
Epstein-Barr viraemia 37.84 12.77 22 41433 1290 34914186
Histoplasmosis cutaneous 37.82 12.77 9 41446 33 34915443
Alveolar proteinosis 37.73 12.77 16 41439 471 34915005
Abdominal wall haemorrhage 37.63 12.77 16 41439 474 34915002
Decreased appetite 37.60 12.77 89 41366 166303 34749173
Histology abnormal 37.50 12.77 14 41441 292 34915184
Somnolence 37.45 12.77 46 41409 111070 34804406
Intentional product misuse 37.21 12.77 5 41450 45606 34869870
Squamous cell carcinoma 36.85 12.77 56 41399 11419 34904057
Pyelonephritis 36.75 12.77 41 41414 6174 34909302
Epstein-Barr virus associated lymphoproliferative disorder 36.67 12.77 25 41430 1939 34913537
Smooth muscle cell neoplasm 36.24 12.77 12 41443 173 34915303
Respiratory failure 35.89 12.77 236 41219 108336 34807140
Pancreas transplant rejection 35.68 12.77 12 41443 182 34915294
Graft versus host disease in liver 35.63 12.77 21 41434 1263 34914213
Acute graft versus host disease 35.23 12.77 41 41414 6462 34909014
Injection site pain 35.07 12.77 3 41452 39002 34876474
Vascular anastomotic haemorrhage 34.70 12.77 13 41442 274 34915202
Transplantation complication 34.41 12.77 11 41444 141 34915335
Papilloma viral infection 34.29 12.77 15 41440 477 34914999
Postoperative wound infection 34.11 12.77 35 41420 4791 34910685
Gastroenteritis Escherichia coli 33.97 12.77 14 41441 383 34915093
Heart transplant rejection 33.81 12.77 20 41435 1211 34914265
Trichophytosis 33.72 12.77 13 41442 297 34915179
Viraemia 33.71 12.77 20 41435 1218 34914258
Malacoplakia gastrointestinal 33.53 12.77 10 41445 100 34915376
Urinoma 33.48 12.77 12 41443 222 34915254
Haemolytic uraemic syndrome 33.26 12.77 25 41430 2261 34913215
Renal transplant 33.26 12.77 23 41432 1826 34913650
Neuropathy peripheral 33.06 12.77 30 41425 83233 34832243
Candida infection 32.91 12.77 68 41387 17647 34897829
Immune reconstitution inflammatory syndrome 32.85 12.77 46 41409 8713 34906763
Hypersensitivity 32.27 12.77 16 41439 61019 34854457
Microsporidia infection 32.04 12.77 16 41439 690 34914786
Osmotic demyelination syndrome 31.95 12.77 17 41438 838 34914638
Glomerulonephritis 31.86 12.77 23 41432 1955 34913521
Erythema 31.80 12.77 35 41420 88745 34826731
Perineal cyst 31.72 12.77 12 41443 260 34915216
Postoperative thoracic procedure complication 31.62 12.77 8 41447 40 34915436
Nausea 31.59 12.77 255 41200 339653 34575823
Myocardial infarction 31.32 12.77 60 41395 121025 34794451
Epistaxis 31.21 12.77 15 41440 58236 34857240
Carotid arteriosclerosis 30.83 12.77 22 41433 1836 34913640
Malaise 30.71 12.77 115 41340 185710 34729766
Prophylaxis against transplant rejection 30.54 12.77 8 41447 47 34915429
Product dose omission issue 30.37 12.77 60 41395 119651 34795825
Asthenia 30.27 12.77 169 41286 245082 34670394
Coronavirus infection 30.02 12.77 31 41424 4276 34911200
Encephalitis 29.99 12.77 40 41415 7237 34908239
Diverticulum intestinal 29.95 12.77 30 41425 3991 34911485
Chronic graft versus host disease in skin 29.87 12.77 17 41438 957 34914519
Cardiac failure congestive 29.63 12.77 33 41422 83237 34832239
Cystitis viral 29.46 12.77 14 41441 541 34914935
Left ventricular hypertrophy 29.46 12.77 42 41413 8088 34907388
Hyperparathyroidism secondary 29.37 12.77 20 41435 1548 34913928
Wrong technique in product usage process 29.22 12.77 4 41451 35982 34879494
Necrotising oesophagitis 29.20 12.77 14 41441 552 34914924
Inappropriate schedule of product administration 29.11 12.77 19 41436 62277 34853199
Chronic graft versus host disease in liver 28.80 12.77 13 41442 446 34915030
Muscle spasms 28.63 12.77 28 41427 74973 34840503
Mycobacterial infection 28.13 12.77 23 41432 2351 34913125
Blood pressure decreased 28.00 12.77 13 41442 51502 34863974
Vascular compression 27.96 12.77 12 41443 364 34915112
Chronic graft versus host disease 27.85 12.77 30 41425 4343 34911133
Back pain 27.61 12.77 65 41390 121724 34793752
Hernial eventration 27.57 12.77 8 41447 72 34915404
Pain in extremity 27.52 12.77 69 41386 126444 34789032
Large intestinal ulcer 27.47 12.77 21 41434 1948 34913528
Meningoencephalitis amoebic 27.36 12.77 9 41446 127 34915349
Hypotension 27.20 12.77 153 41302 221496 34693980
Joint swelling 27.00 12.77 19 41436 59871 34855605
Gastroenteritis sapovirus 26.98 12.77 9 41446 133 34915343
Lung transplant 26.95 12.77 21 41434 2003 34913473
Disseminated mucormycosis 26.78 12.77 13 41442 527 34914949
Pyelonephritis acute 26.63 12.77 21 41434 2038 34913438
Aortic dilatation 26.55 12.77 18 41437 1383 34914093
Ventricular remodelling 26.47 12.77 8 41447 84 34915392
Cerebral aspergillosis 26.20 12.77 18 41437 1414 34914062
Asthma 26.07 12.77 9 41446 42647 34872829
Glomerulonephritis membranoproliferative 25.99 12.77 12 41443 434 34915042
Immunosuppressant drug level decreased 25.91 12.77 17 41438 1237 34914239
Pneumonia escherichia 25.89 12.77 12 41443 438 34915038
Paraesthesia 25.61 12.77 23 41432 64149 34851327
Anogenital warts 25.54 12.77 13 41442 584 34914892
Urticaria 25.33 12.77 22 41433 62355 34853121
Renal vein thrombosis 25.29 12.77 9 41446 163 34915313
Foetal exposure during pregnancy 25.15 12.77 7 41448 38094 34877382
Coronary artery disease 25.03 12.77 13 41442 48292 34867184
Blood 25-hydroxycholecalciferol decreased 24.77 12.77 10 41445 259 34915217
Lung transplant rejection 24.77 12.77 14 41441 778 34914698
Perinephric collection 24.74 12.77 9 41446 174 34915302
Heart rate decreased 24.69 12.77 4 41451 31741 34883735
Neutrophil count decreased 24.68 12.77 15 41440 51089 34864387
Non-cirrhotic portal hypertension 24.52 12.77 10 41445 266 34915210
Human herpesvirus 6 infection 24.32 12.77 20 41435 2061 34913415
Cardio-respiratory arrest 24.31 12.77 18 41437 55255 34860221
Isosporiasis 24.25 12.77 8 41447 114 34915362
Renal graft infection 24.01 12.77 10 41445 281 34915195
Platelet count decreased 23.98 12.77 68 41387 119649 34795827
Drug reaction with eosinophilia and systemic symptoms 23.87 12.77 5 41450 33007 34882469
Hypoglycaemia 23.77 12.77 18 41437 54622 34860854
Musculoskeletal stiffness 23.54 12.77 13 41442 46667 34868809
Pneumonia pseudomonal 23.40 12.77 26 41429 3896 34911580
Blood creatine phosphokinase increased 23.35 12.77 12 41443 44845 34870631
Hyperkalaemia 23.01 12.77 151 41304 69238 34846238
Oesophageal ulcer 22.96 12.77 24 41431 3357 34912119
Vesicoureteral reflux surgery 22.95 12.77 4 41451 0 34915476
Catatonia 22.85 12.77 29 41426 4996 34910480
B-cell lymphoma 22.79 12.77 27 41428 4336 34911140
Electrocardiogram QT prolonged 22.78 12.77 10 41445 40942 34874534
Parvovirus infection 22.75 12.77 11 41444 442 34915034
International normalised ratio increased 22.71 12.77 14 41441 47313 34868163
Suicide attempt 22.65 12.77 9 41446 39107 34876369
Meningoencephalitis viral 22.52 12.77 8 41447 144 34915332
Metabolic acidosis 22.46 12.77 107 41348 43573 34871903
Visceral leishmaniasis 22.39 12.77 12 41443 600 34914876
Gingival hypertrophy 22.33 12.77 18 41437 1803 34913673
Procedural pain 22.28 12.77 28 41427 4778 34910698
Suicidal ideation 22.25 12.77 10 41445 40378 34875098
Seizure 22.17 12.77 58 41397 104799 34810677
Corynebacterium infection 22.16 12.77 12 41443 613 34914863
Seroma 22.05 12.77 12 41443 619 34914857
Chest pain 21.88 12.77 77 41378 126685 34788791
Renal-limited thrombotic microangiopathy 21.80 12.77 7 41448 91 34915385
Bacterial pyelonephritis 21.74 12.77 9 41446 249 34915227
Diarrhoea 21.66 12.77 610 40845 389302 34526174
Aortic pseudoaneurysm 21.64 12.77 6 41449 45 34915431
Cytomegalovirus oesophagitis 21.60 12.77 11 41444 495 34914981
Hyperparathyroidism 21.49 12.77 15 41440 1209 34914267
Feeling abnormal 21.48 12.77 26 41429 63209 34852267
Gait disturbance 21.30 12.77 43 41412 85097 34830379
Tubulointerstitial nephritis 21.29 12.77 64 41391 20960 34894516
Urinary tract infection bacterial 21.27 12.77 18 41437 1930 34913546
Hallucination 21.10 12.77 18 41437 51480 34863996
Cytomegalovirus infection reactivation 20.89 12.77 28 41427 5090 34910386
Infective aortitis 20.87 12.77 5 41450 19 34915457
Insomnia 20.82 12.77 59 41396 103848 34811628
Pathogen resistance 20.76 12.77 39 41416 9443 34906033
Infected lymphocele 20.67 12.77 5 41450 20 34915456
Cholangitis 20.61 12.77 37 41418 8652 34906824
Peripheral swelling 20.60 12.77 37 41418 76504 34838972
Gastrointestinal mucormycosis 20.58 12.77 8 41447 187 34915289
Acute myocardial infarction 20.56 12.77 20 41435 53699 34861777
Secondary immunodeficiency 20.50 12.77 10 41445 410 34915066
Hepatosplenomegaly 20.47 12.77 25 41430 4144 34911332
Creatinine urine increased 20.43 12.77 9 41446 291 34915185
Cardiac failure 20.43 12.77 49 41406 91199 34824277
Bacterial sepsis 20.33 12.77 28 41427 5222 34910254
Neurotoxicity 20.33 12.77 57 41398 17953 34897523
Diffuse mesangial sclerosis 20.21 12.77 6 41449 59 34915417
Nasal cavity cancer 20.19 12.77 8 41447 197 34915279
Necrotising fasciitis fungal 20.11 12.77 5 41450 23 34915453
Myopathy toxic 20.08 12.77 11 41444 575 34914901
Complications of transplanted heart 19.98 12.77 9 41446 307 34915169
Cytomegalovirus nephritis 19.86 12.77 7 41448 123 34915353
Acute graft versus host disease in intestine 19.80 12.77 20 41435 2688 34912788
Anti-erythropoietin antibody negative 19.75 12.77 8 41447 209 34915267
Enterobacter infection 19.72 12.77 19 41436 2411 34913065
Philadelphia positive chronic myeloid leukaemia 19.71 12.77 7 41448 126 34915350
Human herpesvirus 8 infection 19.62 12.77 13 41442 962 34914514
Hospitalisation 19.58 12.77 125 41330 56777 34858699
Leishmaniasis 19.56 12.77 9 41446 323 34915153
Balance disorder 19.54 12.77 12 41443 40642 34874834
Enterovirus infection 19.48 12.77 13 41442 973 34914503
Optic discs blurred 19.44 12.77 6 41449 68 34915408
Bacillary angiomatosis 19.31 12.77 7 41448 134 34915342
Dysgeusia 19.19 12.77 4 41451 26493 34888983
Agitation 19.07 12.77 24 41431 57375 34858101
Acute graft versus host disease in skin 19.04 12.77 27 41428 5174 34910302
Glomerulosclerosis 18.96 12.77 12 41443 821 34914655
Mean cell volume increased 18.90 12.77 21 41434 3148 34912328
Metastatic squamous cell carcinoma 18.88 12.77 10 41445 488 34914988
IgA nephropathy 18.79 12.77 14 41441 1249 34914227
Post procedural urine leak 18.75 12.77 7 41448 146 34915330
Disseminated coccidioidomycosis 18.69 12.77 6 41449 78 34915398
Cytomegalovirus mucocutaneous ulcer 18.69 12.77 6 41449 78 34915398
Intervertebral disc space narrowing 18.69 12.77 13 41442 1042 34914434
Pneumocystis jirovecii infection 18.60 12.77 16 41439 1754 34913722
Hemianopia heteronymous 18.59 12.77 5 41450 33 34915443
Renal tubular acidosis 18.57 12.77 18 41437 2301 34913175
Fungal infection 18.54 12.77 51 41404 15884 34899592
Hypogammaglobulinaemia 18.41 12.77 33 41422 7707 34907769
Mediastinitis 18.32 12.77 11 41444 685 34914791
Rhabdomyolysis 18.30 12.77 33 41422 68130 34847346
Abdominal wall abscess 18.25 12.77 10 41445 523 34914953
Epstein-Barr virus infection reactivation 18.15 12.77 13 41442 1091 34914385
Staphylococcal infection 18.13 12.77 82 41373 32678 34882798
Eccrine squamous syringometaplasia 18.10 12.77 5 41450 37 34915439
Stenotrophomonas infection 18.08 12.77 17 41438 2093 34913383
Aggression 18.04 12.77 12 41443 38952 34876524
Intra-abdominal haemorrhage 18.02 12.77 18 41437 2386 34913090
Angioedema 18.01 12.77 11 41444 37363 34878113
Cutaneous malacoplakia 17.84 12.77 6 41449 91 34915385
Haemoglobinaemia 17.76 12.77 7 41448 170 34915306
Disease recurrence 17.74 12.77 61 41394 21429 34894047
Retinal artery occlusion 17.73 12.77 16 41439 1869 34913607
Human polyomavirus infection 17.64 12.77 11 41444 733 34914743
Gastrointestinal fungal infection 17.61 12.77 7 41448 174 34915302
Transmission of an infectious agent via transplant 17.42 12.77 4 41451 12 34915464
Gastrointestinal mucosa hyperaemia 17.39 12.77 8 41447 287 34915189
Cardiogenic shock 17.36 12.77 5 41450 26613 34888863
Anorectal varices 17.33 12.77 5 41450 44 34915432
Mycobacterium haemophilum infection 17.26 12.77 6 41449 101 34915375
Loss of consciousness 17.26 12.77 46 41409 82621 34832855
Ureteral catheterisation 17.22 12.77 3 41452 0 34915476
Biliary anastomosis complication 17.21 12.77 6 41449 102 34915374
Multiple organ dysfunction syndrome 17.16 12.77 152 41303 76414 34839062
Periostitis 17.06 12.77 8 41447 300 34915176
Respiratory arrest 16.99 12.77 6 41449 28037 34887439
Confusional state 16.86 12.77 101 41354 144059 34771417
Mouth ulceration 16.83 12.77 41 41414 11869 34903607
Ileal ulcer 16.69 12.77 10 41445 620 34914856
Fungal skin infection 16.65 12.77 18 41437 2616 34912860
Urinary fistula 16.64 12.77 6 41449 113 34915363
Glomerulonephritis proliferative 16.57 12.77 7 41448 204 34915272
Disease progression 16.48 12.77 69 41386 108008 34807468
Bacterial infection 16.39 12.77 51 41404 17012 34898464
Flushing 16.39 12.77 9 41446 32411 34883065
Wheezing 16.33 12.77 15 41440 41387 34874089
Hyperglycaemia 16.32 12.77 91 41364 39389 34876087
Double stranded DNA antibody positive 16.32 12.77 7 41448 212 34915264
Renal lymphocele 16.25 12.77 5 41450 56 34915420
Argentine haemorrhagic fever 16.16 12.77 4 41451 18 34915458
Gastric ulcer haemorrhage, obstructive 16.16 12.77 4 41451 18 34915458
Rheumatoid arthritis 16.12 12.77 13 41442 38225 34877251
Cytomegalovirus gastroenteritis 16.08 12.77 7 41448 220 34915256
Prostate cancer 16.07 12.77 14 41441 39635 34875841
Stomatitis 16.07 12.77 16 41439 42498 34872978
Incisional hernia 16.00 12.77 13 41442 1317 34914159
Nephrostomy 15.99 12.77 7 41448 223 34915253
Urosepsis 15.94 12.77 42 41413 12757 34902719
Arthropathy 15.89 12.77 6 41449 26901 34888575
Swelling of eyelid 15.83 12.77 12 41443 1099 34914377
Impaired healing 15.83 12.77 47 41408 15287 34900189
Ureaplasma infection 15.65 12.77 8 41447 363 34915113
Liver transplant 15.47 12.77 17 41438 2517 34912959
Cardiac disorder 15.43 12.77 17 41438 43109 34872367
Graft complication 15.42 12.77 8 41447 374 34915102
End stage renal disease 15.28 12.77 33 41422 8828 34906648
Pyrexia 15.25 12.77 509 40946 332504 34582972
Injury 15.23 12.77 3 41452 20684 34894792
Balamuthia infection 15.14 12.77 3 41452 3 34915473
Chronic kidney disease-mineral and bone disorder 15.06 12.77 8 41447 393 34915083
Propionibacterium infection 15.01 12.77 7 41448 259 34915217
Oesophageal stenosis 14.94 12.77 14 41441 1716 34913760
Pupillary deformity 14.93 12.77 4 41451 26 34915450
Tuberculosis 14.85 12.77 32 41423 8545 34906931
Skin exfoliation 14.79 12.77 7 41448 27425 34888051
Lymphorrhoea 14.74 12.77 5 41450 78 34915398
Acinetobacter bacteraemia 14.74 12.77 6 41449 159 34915317
Chronic hepatitis C 14.62 12.77 8 41447 417 34915059
Plasma cell myeloma 14.58 12.77 17 41438 42020 34873456
Upper gastrointestinal haemorrhage 14.56 12.77 6 41449 25512 34889964
Pneumoperitoneum 14.53 12.77 14 41441 1776 34913700
Chronic kidney disease 14.47 12.77 91 41364 41119 34874357
Haemoglobin decreased 14.42 12.77 212 41243 120560 34794916
Drug resistance 14.42 12.77 65 41390 25862 34889614
Mycobacterium chelonae infection 14.33 12.77 10 41445 805 34914671
Leuconostoc infection 14.28 12.77 3 41452 5 34915471
Vascular hyalinosis 14.23 12.77 5 41450 87 34915389
Herpes zoster cutaneous disseminated 14.23 12.77 6 41449 174 34915302
Sebaceous gland disorder 14.20 12.77 4 41451 32 34915444
Pancreas transplant 14.20 12.77 4 41451 32 34915444
Graft thrombosis 14.12 12.77 7 41448 297 34915179
Brain compression 14.10 12.77 6 41449 178 34915298
Aortic arteriosclerosis 14.01 12.77 22 41433 4614 34910862
Infusion related reaction 13.96 12.77 26 41429 53031 34862445
Transitional cell carcinoma 13.91 12.77 15 41440 2174 34913302
White blood cell count decreased 13.90 12.77 62 41393 95383 34820093
Pneumatosis intestinalis 13.82 12.77 20 41435 3903 34911573
Nephropathy 13.79 12.77 25 41430 5892 34909584
Heart rate increased 13.77 12.77 21 41434 46322 34869154
Disseminated varicella zoster virus infection 13.76 12.77 7 41448 314 34915162
New onset diabetes after transplantation 13.69 12.77 4 41451 37 34915439
Functional gastrointestinal disorder 13.67 12.77 15 41440 2216 34913260
Epstein-Barr virus associated lymphoma 13.67 12.77 9 41446 659 34914817
Lymphadenitis fungal 13.61 12.77 3 41452 7 34915469
Vocal cord thickening 13.59 12.77 4 41451 38 34915438
Steatohepatitis 13.54 12.77 7 41448 325 34915151
Gastroenteritis cryptosporidial 13.54 12.77 6 41449 197 34915279
Serratia infection 13.52 12.77 10 41445 882 34914594
Bilirubin conjugated increased 13.51 12.77 18 41437 3253 34912223
Cranial nerve paralysis 13.50 12.77 4 41451 39 34915437
Herpes simplex hepatitis 13.45 12.77 5 41450 103 34915373
Hepatitis A 13.44 12.77 8 41447 490 34914986
Pneumonia klebsiella 13.38 12.77 18 41437 3282 34912194
Legionella infection 13.37 12.77 8 41447 495 34914981
Emphysematous cystitis 13.36 12.77 5 41450 105 34915371
Wound dehiscence 13.34 12.77 18 41437 3293 34912183
Endocarditis viral 13.33 12.77 3 41452 8 34915468
Bordetella infection 13.23 12.77 5 41450 108 34915368
Aspartate aminotransferase increased 13.20 12.77 39 41416 67744 34847732
Drug level fluctuating 13.19 12.77 8 41447 507 34914969
Nasopharyngitis 13.09 12.77 41 41414 69927 34845549
Passenger lymphocyte syndrome 13.07 12.77 4 41451 44 34915432
Pneumonia proteus 13.07 12.77 3 41452 9 34915467
Small intestine gangrene 13.07 12.77 3 41452 9 34915467
Cytomegalovirus syndrome 13.06 12.77 5 41450 112 34915364
Biopsy kidney abnormal 13.02 12.77 5 41450 113 34915363
Pallor 12.99 12.77 7 41448 25473 34890003
Rash pruritic 12.88 12.77 8 41447 26933 34888543
Nephrosclerosis 12.86 12.77 10 41445 951 34914525
Phaeohyphomycotic brain abscess 12.83 12.77 4 41451 47 34915429
Capillaritis 12.82 12.77 5 41450 118 34915358

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 1235.37 11.17 641 67585 42003 79634159
Transplant rejection 1192.84 11.17 492 67734 18945 79657217
Post transplant lymphoproliferative disorder 994.89 11.17 373 67853 11091 79665071
Kidney transplant rejection 953.78 11.17 351 67875 9895 79666267
Complications of transplanted kidney 678.20 11.17 241 67985 6125 79670037
Polyomavirus-associated nephropathy 584.21 11.17 209 68017 5418 79670744
Immunosuppressant drug level increased 511.55 11.17 216 68010 8811 79667351
COVID-19 490.09 11.17 638 67588 157036 79519126
BK virus infection 466.91 11.17 201 68025 8603 79667559
Thrombotic microangiopathy 435.98 11.17 250 67976 19919 79656243
Cytomegalovirus viraemia 357.37 11.17 188 68038 12633 79663529
Delayed graft function 348.04 11.17 126 68100 3381 79672781
Leukopenia 310.86 11.17 438 67788 116075 79560087
Product use in unapproved indication 297.26 11.17 659 67567 249700 79426462
Epstein-Barr virus infection 280.65 11.17 167 68059 14249 79661913
Transplant dysfunction 278.45 11.17 132 68094 7089 79669073
Blood creatinine increased 277.31 11.17 485 67741 154572 79521590
Renal transplant failure 272.61 11.17 90 68136 1817 79674345
Aspergillus infection 267.88 11.17 180 68046 18981 79657181
Parvovirus B19 infection 265.49 11.17 83 68143 1397 79674765
Chronic allograft nephropathy 233.61 11.17 78 68148 1633 79674529
Cryptococcosis 226.33 11.17 92 68134 3401 79672761
Off label use 223.16 11.17 1430 66796 905785 78770377
Posterior reversible encephalopathy syndrome 217.09 11.17 180 68046 26101 79650061
Acute kidney injury 211.20 11.17 941 67285 518463 79157699
West Nile viral infection 208.61 11.17 63 68163 939 79675223
Renal impairment 207.32 11.17 433 67793 157350 79518812
Nocardiosis 204.34 11.17 99 68127 5580 79670582
Drug level increased 203.34 11.17 208 68018 39443 79636719
JC virus infection 193.99 11.17 85 68141 3796 79672366
Pain 180.70 11.17 202 68024 703600 78972562
Histoplasmosis disseminated 180.46 11.17 70 68156 2283 79673879
Bronchopulmonary aspergillosis 178.55 11.17 150 68076 22144 79654018
Nephropathy toxic 173.13 11.17 142 68084 20277 79655885
Phaeohyphomycosis 165.14 11.17 55 68171 1142 79675020
Fatigue 164.59 11.17 344 67882 929383 78746779
Pneumocystis jirovecii pneumonia 162.10 11.17 168 68058 32340 79643822
Mucormycosis 159.36 11.17 96 68130 8373 79667789
Transplant failure 158.28 11.17 78 68148 4563 79671599
Apoptosis 154.02 11.17 43 68183 477 79675685
Fall 153.39 11.17 116 68110 487513 79188649
Trichodysplasia spinulosa 148.71 11.17 46 68180 746 79675416
Incision site pain 148.02 11.17 64 68162 2766 79673396
Klebsiella infection 147.47 11.17 116 68110 15604 79660558
Graft versus host disease in gastrointestinal tract 145.97 11.17 82 68144 6274 79669888
Adenovirus infection 144.26 11.17 90 68136 8357 79667805
Kidney fibrosis 143.62 11.17 67 68159 3468 79672694
Focal segmental glomerulosclerosis 141.33 11.17 65 68161 3256 79672906
Graft versus host disease in skin 141.24 11.17 79 68147 5994 79670168
Arthralgia 139.21 11.17 171 68055 571632 79104530
Epstein-Barr viraemia 139.18 11.17 57 68169 2148 79674014
Diffuse large B-cell lymphoma 139.12 11.17 101 68125 12048 79664114
Histoplasmosis 135.33 11.17 57 68169 2308 79673854
Polyomavirus viraemia 135.25 11.17 52 68174 1655 79674507
Varicella zoster virus infection 134.88 11.17 69 68157 4372 79671790
Renal tubular atrophy 131.03 11.17 52 68174 1804 79674358
Lymphocele 128.89 11.17 50 68176 1631 79674531
Graft loss 128.42 11.17 44 68182 999 79675163
Pseudomonas infection 126.39 11.17 120 68106 20783 79655379
Escherichia infection 123.62 11.17 111 68115 17906 79658256
Blastomycosis 123.46 11.17 39 68187 680 79675482
Brain abscess 122.45 11.17 67 68159 4869 79671293
Malacoplakia 119.67 11.17 37 68189 599 79675563
COVID-19 pneumonia 119.16 11.17 135 68091 28714 79647448
Rash 118.90 11.17 195 68031 578163 79097999
Respiratory failure 118.27 11.17 382 67844 180529 79495633
Liver transplant rejection 118.00 11.17 57 68169 3191 79672971
Aplasia pure red cell 117.94 11.17 77 68149 7733 79668429
Multiple organ dysfunction syndrome 117.86 11.17 294 67932 119952 79556210
Cytomegalovirus colitis 114.58 11.17 63 68163 4622 79671540
Haemophagocytic lymphohistiocytosis 114.57 11.17 116 68110 21721 79654441
Cystitis haemorrhagic 113.64 11.17 80 68146 9092 79667070
Enterococcal infection 112.45 11.17 99 68127 15561 79660601
Hepatitis E 110.29 11.17 53 68173 2933 79673229
Disseminated cryptococcosis 107.61 11.17 45 68181 1789 79674373
Septic shock 106.72 11.17 287 67939 122514 79553648
Strongyloidiasis 105.33 11.17 56 68170 3842 79672320
Proteinuria 104.61 11.17 134 68092 32368 79643794
Drug hypersensitivity 103.35 11.17 64 68162 298852 79377310
Acute respiratory distress syndrome 103.35 11.17 156 68070 43911 79632251
Renal tubular necrosis 101.43 11.17 116 68110 24923 79651239
Hypersensitivity 101.04 11.17 49 68177 262190 79413972
Pulmonary nocardiosis 100.53 11.17 39 68187 1272 79674890
Diabetes mellitus 100.37 11.17 213 68013 78177 79597985
Pruritus 100.23 11.17 114 68112 394534 79281628
Arthropathy 99.69 11.17 16 68210 177095 79499067
Dizziness 96.91 11.17 190 68036 526251 79149911
Joint swelling 95.43 11.17 65 68161 288581 79387581
Drug interaction 95.00 11.17 644 67582 414539 79261623
Progressive multifocal leukoencephalopathy 94.76 11.17 102 68124 20498 79655664
Renal artery stenosis 94.02 11.17 50 68176 3432 79672730
Protein urine present 91.37 11.17 73 68153 10039 79666123
Graft versus host disease 90.34 11.17 86 68140 14940 79661222
Human herpesvirus 6 infection 88.64 11.17 56 68170 5314 79670848
Lymphopenia 87.56 11.17 119 68107 30438 79645724
Encephalitis viral 86.92 11.17 43 68183 2536 79673626
Pneumonia cytomegaloviral 84.99 11.17 53 68173 4916 79671246
Alternaria infection 84.86 11.17 29 68197 653 79675509
Anxiety 83.43 11.17 55 68171 248457 79427705
Scedosporium infection 82.50 11.17 35 68191 1443 79674719
Gastroenteritis norovirus 82.17 11.17 44 68182 3062 79673100
Acanthamoeba infection 80.97 11.17 26 68200 479 79675683
Infusion related reaction 78.59 11.17 50 68176 230187 79445975
Depression 78.32 11.17 44 68182 216746 79459416
Tubulointerstitial nephritis 78.05 11.17 127 68099 38108 79638054
Rhodococcus infection 77.68 11.17 23 68203 319 79675843
Infection reactivation 76.99 11.17 40 68186 2617 79673545
Hand deformity 75.80 11.17 3 68223 103916 79572246
Lymphocyte count decreased 75.57 11.17 141 68085 47148 79629014
Disseminated tuberculosis 75.06 11.17 46 68180 4137 79672025
Renal tubular injury 75.04 11.17 33 68193 1486 79674676
Injection site pain 74.72 11.17 11 68215 129827 79546335
Contraindicated product administered 73.00 11.17 22 68204 157516 79518646
Haemolytic uraemic syndrome 72.45 11.17 46 68180 4403 79671759
Malaise 72.25 11.17 199 68027 489670 79186492
Synovitis 71.77 11.17 20 68206 150714 79525448
Neutrophil count increased 71.69 11.17 106 68120 29290 79646872
Pneumonia cryptococcal 71.50 11.17 32 68194 1503 79674659
Hydronephrosis 70.93 11.17 81 68145 17373 79658789
Malignant neoplasm progression 70.70 11.17 15 68211 135975 79540187
Pancreas transplant rejection 70.10 11.17 21 68205 304 79675858
Intentional overdose 68.42 11.17 6 68220 105954 79570208
Angiosarcoma 66.00 11.17 22 68204 458 79675704
Graft versus host disease in lung 65.95 11.17 26 68200 886 79675276
Red blood cells urine positive 65.49 11.17 45 68181 4918 79671244
Constipation 64.25 11.17 89 68137 282961 79393201
Therapeutic product effect decreased 64.03 11.17 30 68196 163833 79512329
Cryptosporidiosis infection 63.79 11.17 24 68202 719 79675443
Epstein-Barr virus associated lymphoproliferative disorder 63.78 11.17 39 68187 3493 79672669
Squamous cell carcinoma of skin 63.69 11.17 69 68157 13964 79662198
Malacoplakia gastrointestinal 62.85 11.17 17 68209 166 79675996
Alveolar proteinosis 62.38 11.17 24 68202 765 79675397
Blood urea increased 61.77 11.17 132 68094 48658 79627504
Renal cyst haemorrhage 61.77 11.17 23 68203 669 79675493
Papilloma viral infection 61.69 11.17 30 68196 1704 79674458
Cat scratch disease 61.66 11.17 20 68206 381 79675781
Renal transplant 61.60 11.17 34 68192 2513 79673649
Meningitis cryptococcal 61.50 11.17 38 68188 3468 79672694
Human polyomavirus infection 61.10 11.17 26 68200 1080 79675082
Donor specific antibody present 59.99 11.17 18 68208 262 79675900
Pain in extremity 59.16 11.17 141 68085 364397 79311765
Ureaplasma infection 59.06 11.17 25 68201 1025 79675137
Candida infection 58.65 11.17 112 68114 38102 79638060
Intraductal papillary mucinous neoplasm 58.58 11.17 23 68203 775 79675387
Viraemia 57.83 11.17 34 68192 2835 79673327
Post transplant distal limb syndrome 57.46 11.17 21 68205 579 79675583
Stomatitis 57.13 11.17 27 68199 146730 79529432
Dyspnoea 56.99 11.17 465 67761 856560 78819602
Central nervous system lymphoma 56.58 11.17 31 68195 2258 79673904
Disseminated mucormycosis 56.47 11.17 22 68204 726 79675436
Wound 56.08 11.17 15 68211 116164 79559998
American trypanosomiasis 55.73 11.17 18 68208 338 79675824
Contusion 55.46 11.17 29 68197 148747 79527415
Ureteric stenosis 55.36 11.17 26 68200 1366 79674796
Immunosuppressant drug level decreased 54.74 11.17 29 68197 1975 79674187
Urinoma 54.64 11.17 16 68210 213 79675949
Dermatophytosis 54.38 11.17 19 68207 458 79675704
Escherichia urinary tract infection 54.23 11.17 63 68163 13762 79662400
Discomfort 53.90 11.17 20 68206 125597 79550565
Acinetobacter infection 53.59 11.17 32 68194 2745 79673417
Cystitis viral 53.50 11.17 21 68205 707 79675455
Musculoskeletal stiffness 53.17 11.17 43 68183 174965 79501197
Rheumatoid arthritis 53.09 11.17 60 68166 208410 79467752
Chromoblastomycosis 52.92 11.17 13 68213 83 79676079
Bacillary angiomatosis 52.70 11.17 16 68210 243 79675919
Nausea 52.56 11.17 545 67681 956651 78719511
Glomerulonephritis 52.21 11.17 34 68192 3399 79672763
Histoplasmosis cutaneous 52.19 11.17 12 68214 55 79676107
Oesophageal ulcer 51.89 11.17 45 68181 6930 79669232
Injection site erythema 51.66 11.17 4 68222 78193 79597969
Peripheral swelling 51.53 11.17 95 68131 269522 79406640
Human ehrlichiosis 51.51 11.17 19 68207 538 79675624
Back pain 51.48 11.17 115 68111 304065 79372097
Alopecia 51.24 11.17 74 68152 231281 79444881
Urticaria 50.87 11.17 50 68176 185151 79491011
Pathogen resistance 50.73 11.17 62 68164 14280 79661882
Mycobacterial infection 50.16 11.17 34 68192 3634 79672528
Lung transplant rejection 50.04 11.17 25 68201 1506 79674656
Decreased appetite 49.76 11.17 140 68086 342278 79333884
Acute graft versus host disease 49.69 11.17 52 68174 10115 79666047
Wheezing 49.34 11.17 19 68207 116645 79559517
Actinic keratosis 49.08 11.17 41 68185 6001 79670161
Pyelonephritis 48.97 11.17 73 68153 20315 79655847
Intentional product misuse 48.44 11.17 11 68215 95154 79581008
Emphysematous pyelonephritis 47.91 11.17 16 68210 335 79675827
Microsporidia infection 47.77 11.17 21 68205 945 79675217
Drug resistance 47.56 11.17 109 68117 42104 79634058
Urinary tract infection 47.52 11.17 399 67827 274113 79402049
Syncope 47.51 11.17 50 68176 179399 79496763
Rectal prolapse 47.05 11.17 27 68199 2151 79674011
Chronic graft versus host disease 46.95 11.17 42 68184 6739 79669423
Asthenia 46.86 11.17 252 67974 511437 79164725
Graft versus host disease in liver 46.83 11.17 25 68201 1729 79674433
Distributive shock 46.82 11.17 29 68197 2658 79673504
End stage renal disease 46.78 11.17 55 68171 12165 79663997
Toxoplasmosis 46.72 11.17 29 68197 2668 79673494
Asthma 46.54 11.17 29 68197 135066 79541096
Insomnia 46.30 11.17 87 68139 245083 79431079
Nasopharyngitis 46.29 11.17 92 68134 253789 79422373
Chronic kidney disease 46.19 11.17 143 68083 66011 79610151
Encephalitis 46.15 11.17 60 68166 14700 79661462
Pericarditis 45.73 11.17 16 68210 104220 79571942
Diarrhoea 45.47 11.17 1028 67198 879461 78796701
Anogenital warts 45.20 11.17 20 68206 914 79675248
Oesophageal stenosis 44.92 11.17 34 68192 4320 79671842
Philadelphia positive chronic myeloid leukaemia 44.89 11.17 13 68213 166 79675996
Smooth muscle cell neoplasm 44.64 11.17 20 68206 942 79675220
Herpes simplex hepatitis 44.60 11.17 17 68209 528 79675634
Heart transplant rejection 44.52 11.17 23 68203 1487 79674675
Immune reconstitution inflammatory syndrome 44.43 11.17 57 68169 13784 79662378
SARS-CoV-2 antibody test positive 44.41 11.17 16 68210 423 79675739
Erythema 44.17 11.17 77 68149 223213 79452949
Pancreatitis haemorrhagic 44.16 11.17 19 68207 811 79675351
B-cell lymphoma 44.04 11.17 39 68187 6176 79669986
Vena cava injury 43.93 11.17 15 68211 337 79675825
Bacterial pyelonephritis 43.89 11.17 17 68209 552 79675610
Balance disorder 43.67 11.17 15 68211 98842 79577320
Mycobacterium haemophilum infection 43.66 11.17 12 68214 125 79676037
Cytomegalovirus infection reactivation 43.36 11.17 45 68181 8671 79667491
Fibromyalgia 43.34 11.17 3 68223 64337 79611825
Angiosarcoma metastatic 42.67 11.17 12 68214 137 79676025
Osteoarthritis 42.66 11.17 11 68215 87298 79588864
Trichophytosis 42.42 11.17 15 68211 375 79675787
Cytomegalovirus nephritis 41.89 11.17 12 68214 147 79676015
Coronavirus infection 41.48 11.17 41 68185 7456 79668706
Hyperhidrosis 41.48 11.17 41 68185 151451 79524711
Injury 41.41 11.17 8 68218 77488 79598674
Chronic obstructive pulmonary disease 41.28 11.17 11 68215 85408 79590754
Nephropathy 40.94 11.17 46 68180 9692 79666470
Squamous cell carcinoma 40.51 11.17 58 68168 15564 79660598
Bacterial sepsis 40.19 11.17 42 68184 8156 79668006
Human herpesvirus 8 infection 40.10 11.17 20 68206 1200 79674962
Paraesthesia 39.43 11.17 56 68170 176267 79499895
Blister 39.32 11.17 27 68199 119449 79556713
Urinary fistula 39.31 11.17 10 68216 75 79676087
Lupus nephritis 39.04 11.17 27 68199 2981 79673181
Left ventricular hypertrophy 38.97 11.17 48 68178 11143 79665019
Prophylaxis against transplant rejection 38.85 11.17 10 68216 79 79676083
Vascular anastomotic haemorrhage 38.85 11.17 13 68213 274 79675888
Myocardial infarction 38.73 11.17 61 68165 184068 79492094
Hospitalisation 38.25 11.17 171 68055 94065 79582097
Feeling abnormal 38.20 11.17 48 68178 159151 79517011
Sepsis 38.15 11.17 375 67851 269053 79407109
Oesophageal candidiasis 37.83 11.17 43 68183 9175 79666987
Muscle spasms 37.60 11.17 57 68169 174673 79501489
Swelling 37.41 11.17 81 68145 216630 79459532
Abdominal wall haemorrhage 37.30 11.17 16 68210 678 79675484
Confusional state 37.21 11.17 143 68083 317854 79358308
Hyperparathyroidism secondary 37.19 11.17 25 68201 2635 79673527
Gastroenteritis sapovirus 37.19 11.17 11 68215 152 79676010
Lung transplant 37.15 11.17 31 68195 4530 79671632
Atypical haemolytic uraemic syndrome 37.15 11.17 18 68208 1014 79675148
Enterobacter infection 37.15 11.17 31 68195 4531 79671631
Renal-limited thrombotic microangiopathy 37.12 11.17 11 68215 153 79676009
Biopsy lung abnormal 36.86 11.17 11 68215 157 79676005
Metastatic squamous cell carcinoma 36.83 11.17 15 68211 557 79675605
Transplantation complication 36.76 11.17 13 68213 325 79675837
Suicidal ideation 36.57 11.17 10 68216 76330 79599832
Heart rate decreased 36.04 11.17 8 68218 70308 79605854
Necrotising oesophagitis 35.86 11.17 18 68208 1095 79675067
Glomerulosclerosis 35.73 11.17 18 68208 1104 79675058
Drug reaction with eosinophilia and systemic symptoms 35.69 11.17 6 68220 64238 79611924
Perineal cyst 35.68 11.17 12 68214 257 79675905
Hypoaesthesia 35.32 11.17 62 68164 179290 79496872
Hernial eventration 35.32 11.17 9 68217 68 79676094
Staphylococcal infection 35.27 11.17 120 68106 58175 79617987
Disease recurrence 35.22 11.17 100 68126 44009 79632153
Central nervous system lupus 35.18 11.17 14 68212 489 79675673
Cardiac failure congestive 35.15 11.17 42 68184 142360 79533802
Hypogammaglobulinaemia 34.94 11.17 49 68177 12902 79663260
Chronic graft versus host disease in liver 34.61 11.17 15 68211 652 79675510
Inappropriate schedule of product administration 34.51 11.17 38 68188 133590 79542572
Irritable bowel syndrome 34.17 11.17 6 68220 62235 79613927
Oedematous kidney 34.09 11.17 11 68215 206 79675956
Renal graft infection 33.97 11.17 14 68212 536 79675626
Product dose omission issue 33.91 11.17 104 68122 247433 79428729
Meningoencephalitis amoebic 33.89 11.17 10 68216 137 79676025
Gait disturbance 33.83 11.17 80 68146 207426 79468736
Stress 33.60 11.17 13 68213 79599 79596563
Mobility decreased 33.52 11.17 33 68193 122142 79554020
Pyelonephritis acute 33.44 11.17 33 68193 5990 79670172
Gastrointestinal mucormycosis 33.37 11.17 13 68213 429 79675733
Urinary tract infection bacterial 33.32 11.17 34 68192 6422 79669740
Epstein-Barr virus associated lymphoma 33.30 11.17 17 68209 1072 79675090
Lower respiratory tract infection 33.10 11.17 37 68189 129183 79546979
Wrong technique in product usage process 32.99 11.17 11 68215 73864 79602298
Cerebral aspergillosis 32.86 11.17 20 68206 1776 79674386
Haemoglobin decreased 32.83 11.17 312 67914 221807 79454355
Chronic graft versus host disease in skin 32.64 11.17 19 68207 1555 79674607
Abdominal discomfort 32.48 11.17 108 68118 250619 79425543
Obliterative bronchiolitis 32.02 11.17 24 68202 3004 79673158
Headache 31.90 11.17 382 67844 653390 79022772
Fungal infection 31.74 11.17 93 68133 41655 79634507
Gastroenteritis Escherichia coli 31.62 11.17 14 68212 641 79675521
Metabolic acidosis 31.44 11.17 147 68079 82382 79593780
Neutrophil count decreased 31.22 11.17 21 68205 93938 79582224
Folliculitis 31.15 11.17 5 68221 55375 79620787
Renal lymphocele 31.15 11.17 9 68217 114 79676048
Suicide attempt 31.14 11.17 16 68210 82916 79593246
Disseminated varicella zoster vaccine virus infection 31.07 11.17 9 68217 115 79676047
Ventricular remodelling 31.00 11.17 9 68217 116 79676046
Hepatic enzyme increased 30.90 11.17 69 68157 182541 79493621
Mycobacterium avium complex infection 30.88 11.17 28 68198 4572 79671590
Pneumocystis jirovecii infection 30.74 11.17 23 68203 2871 79673291
Injection site reaction 30.70 11.17 5 68221 54780 79621382
Osmotic demyelination syndrome 30.68 11.17 18 68208 1495 79674667
Hepatic angiosarcoma 30.64 11.17 7 68219 31 79676131
Mouth ulceration 30.61 11.17 87 68139 38307 79637855
Coccidioidomycosis 30.33 11.17 17 68209 1295 79674867
Electrocardiogram QT prolonged 30.31 11.17 20 68206 90366 79585796
Carotid arteriosclerosis 30.22 11.17 22 68204 2634 79673528
Cerebral toxoplasmosis 30.19 11.17 21 68205 2341 79673821
Dry mouth 30.16 11.17 19 68207 88000 79588162
Vascular compression 30.08 11.17 13 68213 561 79675601
Malacoplakia vesicae 29.96 11.17 8 68218 74 79676088
Large intestinal ulcer 29.87 11.17 28 68198 4769 79671393
Sinusitis 29.82 11.17 78 68148 195423 79480739
Pancytopenia 29.76 11.17 243 67983 165502 79510660
Weight increased 29.16 11.17 130 68096 277256 79398906
Hypotension 29.10 11.17 239 67987 440078 79236084
Complications of transplanted lung 29.06 11.17 12 68214 462 79675700
Biloma 28.98 11.17 9 68217 148 79676014
Hyperkalaemia 28.83 11.17 182 68044 114216 79561946
Respiratory arrest 28.60 11.17 7 68219 57543 79618619
Pneumonia pseudomonal 28.47 11.17 30 68196 5881 79670281
Helicobacter infection 28.41 11.17 12 68214 69692 79606470
Perinephric collection 28.38 11.17 11 68215 358 79675804
Complications of transplanted heart 28.35 11.17 11 68215 359 79675803
Epidermodysplasia verruciformis 28.06 11.17 11 68215 369 79675793
Ureteral necrosis 28.00 11.17 8 68218 97 79676065
Cardio-respiratory arrest 27.86 11.17 31 68195 108479 79567683
Transplantation associated food allergy 27.86 11.17 8 68218 99 79676063
Aortic dilatation 27.69 11.17 18 68208 1794 79674368
Biliary anastomosis complication 27.62 11.17 9 68217 174 79675988
Chest pain 27.50 11.17 136 68090 282168 79393994
Calciphylaxis 27.40 11.17 24 68202 3746 79672416
Escherichia pyelonephritis 27.34 11.17 12 68214 538 79675624
Visceral leishmaniasis 27.18 11.17 15 68211 1108 79675054
Gastroenteritis cryptosporidial 27.15 11.17 10 68216 282 79675880
Blood pressure decreased 27.13 11.17 27 68199 99439 79576723
Gingival hypertrophy 26.94 11.17 22 68204 3120 79673042
Chemical peritonitis 26.85 11.17 10 68216 291 79675871
Cytomegalovirus syndrome 26.85 11.17 10 68216 291 79675871
Pneumopericardium 26.84 11.17 9 68217 191 79675971
Cytomegalovirus chorioretinitis 26.69 11.17 28 68198 5462 79670700
Loss of personal independence in daily activities 26.68 11.17 29 68197 102551 79573611
Cytomegalovirus oesophagitis 26.59 11.17 13 68213 747 79675415
Cytomegalovirus test positive 26.56 11.17 29 68197 5918 79670244
Necrotising herpetic retinopathy 26.50 11.17 8 68218 119 79676043
Febrile neutropenia 26.29 11.17 105 68121 230894 79445268
Fungal skin infection 26.21 11.17 29 68197 6007 79670155
Cytomegalovirus hepatitis 26.21 11.17 13 68213 771 79675391
Pemphigus 26.07 11.17 28 68198 99554 79576608
Opportunistic infection 26.02 11.17 21 68205 2929 79673233
Liver transplant 25.99 11.17 25 68201 4398 79671764
Neuropathy peripheral 25.91 11.17 51 68175 141254 79534908
Injection site pruritus 25.71 11.17 3 68223 42280 79633882
Klebsiella bacteraemia 25.65 11.17 21 68205 2989 79673173
Chronic hepatitis C 25.37 11.17 12 68214 641 79675521
Acute graft versus host disease in skin 25.31 11.17 32 68194 7626 79668536
Flushing 25.19 11.17 23 68203 88245 79587917
Arthritis 25.17 11.17 37 68189 114843 79561319
Bacterial infection 25.05 11.17 71 68155 31209 79644953
Neuroendocrine carcinoma of the skin 25.01 11.17 15 68211 1297 79674865
Vaccination failure 24.92 11.17 17 68209 1836 79674326
Renal failure 24.77 11.17 272 67954 200696 79475466
Somnolence 24.52 11.17 113 68113 238868 79437294
Pneumonia escherichia 24.51 11.17 13 68213 887 79675275
Memory impairment 24.46 11.17 36 68190 111698 79564464
Perinephric abscess 24.43 11.17 9 68217 254 79675908
Pyrexia 24.37 11.17 756 67470 677953 78998209
Blood 25-hydroxycholecalciferol decreased 24.36 11.17 10 68216 379 79675783
Herpes simplex 24.21 11.17 40 68186 12147 79664015
New onset diabetes after transplantation 24.21 11.17 8 68218 162 79676000
Encephalitis cytomegalovirus 24.16 11.17 14 68212 1136 79675026
Enterovirus infection 24.16 11.17 17 68209 1930 79674232
Loss of consciousness 24.11 11.17 69 68157 167874 79508288
Knee arthroplasty 24.11 11.17 4 68222 43244 79632918
Acute graft versus host disease in intestine 24.05 11.17 23 68203 4018 79672144
Postoperative thoracic procedure complication 23.99 11.17 7 68219 92 79676070
Hypoglycaemia 23.98 11.17 31 68195 101563 79574599
Transmission of an infectious agent via transplant 23.93 11.17 5 68221 13 79676149
Pneumonia fungal 23.91 11.17 38 68188 11172 79664990
Tuberculosis 23.88 11.17 45 68181 15153 79661009
Aortic pseudoaneurysm 23.59 11.17 6 68220 45 79676117
Infective aortitis 23.47 11.17 6 68220 46 79676116
Catatonia 23.43 11.17 33 68193 8723 79667439
Isosporiasis 23.42 11.17 8 68218 180 79675982
Meningitis bacterial 23.15 11.17 19 68207 2713 79673449
Meningoencephalitis viral 22.98 11.17 10 68216 439 79675723
Superinfection bacterial 22.95 11.17 15 68211 1509 79674653
Steroid diabetes 22.87 11.17 21 68205 3485 79672677
Mycobacterium chelonae infection 22.76 11.17 18 68208 2438 79673724
Liver abscess 22.76 11.17 27 68199 6027 79670135
Maternal exposure during pregnancy 22.76 11.17 52 68174 136486 79539676
Hepatosplenomegaly 22.71 11.17 27 68199 6042 79670120
Psoriasis 22.56 11.17 26 68200 89561 79586601
Nosocomial infection 22.56 11.17 19 68207 2813 79673349
Passenger lymphocyte syndrome 22.54 11.17 7 68219 115 79676047
Propionibacterium infection 22.52 11.17 9 68217 318 79675844
Cutaneous malacoplakia 22.43 11.17 7 68219 117 79676045
Neurotoxicity 22.42 11.17 70 68156 32448 79643714
Anti-erythropoietin antibody negative 22.41 11.17 9 68217 322 79675840
Injection site bruising 22.40 11.17 4 68222 40998 79635164
Histology abnormal 22.36 11.17 9 68217 324 79675838
Secondary immunodeficiency 22.33 11.17 20 68206 3214 79672948
Epstein-Barr virus infection reactivation 22.28 11.17 16 68210 1876 79674286
Periostitis 22.23 11.17 11 68215 649 79675513
Drug dependence 22.23 11.17 4 68222 40765 79635397
Corynebacterium infection 22.20 11.17 14 68212 1324 79674838
Mastitis bacterial 21.87 11.17 6 68220 62 79676100
Organising pneumonia 21.86 11.17 36 68190 10903 79665259
Clostridium difficile colitis 21.81 11.17 69 68157 32214 79643948
Cytomegalovirus gastrointestinal infection 21.72 11.17 10 68216 502 79675660
Spindle cell sarcoma 21.70 11.17 8 68218 226 79675936
Acarodermatitis 21.64 11.17 14 68212 1384 79674778
Emotional distress 21.62 11.17 4 68222 39965 79636197
Diffuse mesangial sclerosis 21.62 11.17 6 68220 65 79676097
Benign prostatic hyperplasia 21.59 11.17 37 68189 11575 79664587
Necrotising fasciitis fungal 21.55 11.17 5 68221 24 79676138
Dysgeusia 21.51 11.17 11 68215 57166 79618996
Hallucination 21.46 11.17 25 68201 85720 79590442
Pulmonary mucormycosis 21.39 11.17 13 68213 1152 79675010
Serotonin syndrome 21.37 11.17 6 68220 45021 79631141
Optic discs blurred 21.37 11.17 6 68220 68 79676094
Herpes simplex oesophagitis 21.28 11.17 9 68217 368 79675794
Chronic kidney disease-mineral and bone disorder 21.19 11.17 10 68216 531 79675631
Nasal cavity cancer 21.19 11.17 8 68218 242 79675920
Neck pain 21.11 11.17 20 68206 75397 79600765
Diabetic macroangiopathy 21.03 11.17 7 68219 145 79676017
Pneumoperitoneum 21.02 11.17 19 68207 3089 79673073
Graft complication 20.91 11.17 11 68215 738 79675424
Leishmaniasis 20.90 11.17 9 68217 385 79675777
Mycobacterium abscessus infection 20.81 11.17 13 68213 1209 79674953
Agranulocytosis 20.80 11.17 85 68141 44945 79631217
Exposure during pregnancy 20.79 11.17 34 68192 101098 79575064
Medication error 20.67 11.17 17 68209 68625 79607537
Epistaxis 20.66 11.17 40 68186 111475 79564687
Tuberculosis gastrointestinal 20.63 11.17 10 68216 564 79675598
Lymphadenitis fungal 20.60 11.17 4 68222 6 79676156
Glomerulonephritis proliferative 20.60 11.17 9 68217 399 79675763
Systemic candida 20.56 11.17 27 68199 6679 79669483
Drug level fluctuating 20.51 11.17 11 68215 768 79675394
Renal tubular acidosis 20.43 11.17 20 68206 3594 79672568
Mycoplasma infection 20.38 11.17 11 68215 778 79675384
Bacteraemia 20.23 11.17 68 68158 32756 79643406
Eccrine squamous syringometaplasia 20.21 11.17 5 68221 33 79676129
Hyperammonaemia 20.17 11.17 35 68191 11058 79665104
Obesity 20.14 11.17 3 68223 35122 79641040
Urosepsis 20.12 11.17 59 68167 26436 79649726
Rash pruritic 20.05 11.17 19 68207 71610 79604552
Pneumatosis intestinalis 19.99 11.17 26 68200 6371 79669791
Peritonitis 19.93 11.17 61 68165 27975 79648187
Postoperative wound infection 19.90 11.17 38 68188 12923 79663239
Hyperuricaemia 19.87 11.17 36 68190 11763 79664399
Balamuthia infection 19.83 11.17 5 68221 36 79676126
Listeriosis 19.81 11.17 16 68210 2234 79673928
Acute graft versus host disease in liver 19.72 11.17 15 68211 1920 79674242
Drug effective for unapproved indication 19.71 11.17 25 68201 5976 79670186
Stenotrophomonas infection 19.71 11.17 20 68206 3753 79672409
Hepatitis C 19.60 11.17 36 68190 11889 79664273
Necrotising fasciitis 19.55 11.17 25 68201 6025 79670137
Diverticulum intestinal 19.51 11.17 30 68196 8575 79667587
Orthostatic hypotension 19.41 11.17 12 68214 56152 79620010
Double stranded DNA antibody positive 19.36 11.17 9 68217 462 79675700
Oliguria 19.36 11.17 43 68183 16266 79659896
Orthobunyavirus test positive 19.26 11.17 4 68222 10 79676152
Butterfly rash 19.19 11.17 14 68212 1682 79674480
Cryptococcal cutaneous infection 19.08 11.17 7 68219 195 79675967
Human herpesvirus 6 encephalitis 19.05 11.17 10 68216 668 79675494
Illness 18.97 11.17 8 68218 46503 79629659
Haemolytic anaemia 18.96 11.17 45 68181 17775 79658387
Angiocentric lymphoma 18.92 11.17 11 68215 898 79675264
Parvovirus infection 18.85 11.17 10 68216 683 79675479
International normalised ratio increased 18.84 11.17 27 68199 84694 79591468
Bordetella infection 18.81 11.17 6 68220 108 79676054
Anti-GAD antibody positive 18.75 11.17 5 68221 46 79676116
Anorectal varices 18.75 11.17 5 68221 46 79676116
Respiratory distress 18.73 11.17 99 68127 58240 79617922
Argentine haemorrhagic fever 18.72 11.17 4 68222 12 79676150
Dermatitis papillaris capillitii 18.72 11.17 4 68222 12 79676150
Colitis 18.69 11.17 117 68109 73190 79602972
IgA nephropathy 18.67 11.17 14 68212 1754 79674408
Type 2 diabetes mellitus 18.67 11.17 13 68213 57109 79619053
Hot flush 18.59 11.17 12 68214 54865 79621297
Sleep disorder due to general medical condition, insomnia type 18.57 11.17 7 68219 43549 79632613
Polyomavirus test positive 18.44 11.17 7 68219 215 79675947
Eczema 18.36 11.17 6 68220 40812 79635350
Wound complication 18.33 11.17 22 68204 4971 79671191
Pallor 18.29 11.17 10 68216 50052 79626110
Agitation 18.27 11.17 36 68190 99679 79576483
Locked-in syndrome 18.24 11.17 10 68216 729 79675433
Vesicoureteral reflux surgery 18.19 11.17 3 68223 0 79676162
Palpitations 18.18 11.17 52 68174 126558 79549604
Fungaemia 18.14 11.17 21 68205 4570 79671592
Acid base balance abnormal 18.11 11.17 8 68218 364 79675798
Bilirubin conjugated increased 18.07 11.17 23 68203 5516 79670646
Complications of transplant surgery 18.02 11.17 10 68216 747 79675415
Blood creatine phosphokinase increased 17.95 11.17 18 68208 66072 79610090
Pyelonephritis fungal 17.94 11.17 7 68219 232 79675930
Neoplasm progression 17.92 11.17 11 68215 51671 79624491
Abdominal pain upper 17.89 11.17 115 68111 223704 79452458
Swollen tongue 17.88 11.17 7 68219 42563 79633599
Phaeohyphomycotic brain abscess 17.78 11.17 5 68221 57 79676105
Systemic bacterial infection 17.78 11.17 5 68221 57 79676105
Urinary tract candidiasis 17.77 11.17 10 68216 767 79675395
Creatinine urine increased 17.74 11.17 9 68217 560 79675602
Blood pressure increased 17.72 11.17 107 68119 211253 79464909
Renal vein thrombosis 17.71 11.17 9 68217 562 79675600
Toxic epidermal necrolysis 17.65 11.17 8 68218 44573 79631589
Ejection fraction decreased 17.58 11.17 4 68222 34573 79641589
Azotaemia 17.58 11.17 28 68198 8248 79667914
Gastric ulcer haemorrhage, obstructive 17.46 11.17 4 68222 18 79676144
Endocarditis 17.43 11.17 32 68194 10565 79665597
Acute pulmonary histoplasmosis 17.42 11.17 7 68219 251 79675911
Obstructive airways disorder 17.34 11.17 3 68223 31456 79644706
Rectal haemorrhage 17.28 11.17 24 68202 76276 79599886
Colon injury 17.24 11.17 7 68219 258 79675904
Systemic lupus erythematosus 17.22 11.17 50 68176 121099 79555063
Drug eruption 17.22 11.17 8 68218 43927 79632235
Transient ischaemic attack 17.21 11.17 12 68214 52683 79623479
Drug level decreased 17.12 11.17 38 68188 14364 79661798
Disseminated coccidioidomycosis 17.12 11.17 6 68220 146 79676016
Lymphorrhoea 16.89 11.17 6 68220 152 79676010
Disseminated varicella zoster virus infection 16.84 11.17 9 68217 624 79675538
Dry skin 16.83 11.17 20 68206 67975 79608187
Mediastinitis 16.79 11.17 10 68216 854 79675308
Functional gastrointestinal disorder 16.73 11.17 21 68205 4969 79671193
Ileal ulcer 16.72 11.17 11 68215 1119 79675043
Intervertebral disc space narrowing 16.70 11.17 13 68213 1722 79674440
Acute myocardial infarction 16.69 11.17 25 68201 77011 79599151
Graft thrombosis 16.66 11.17 8 68218 442 79675720
Mucinous adenocarcinoma of appendix 16.64 11.17 4 68222 23 79676139
Bursitis 16.60 11.17 5 68221 35839 79640323
Hyperglycaemia 16.55 11.17 110 68116 70225 79605937
Hip arthroplasty 16.54 11.17 5 68221 35751 79640411
Haemoglobinaemia 16.53 11.17 7 68219 287 79675875
Sleep disorder 16.51 11.17 30 68196 85647 79590515
Pneumonia klebsiella 16.51 11.17 21 68205 5033 79671129
Full blood count abnormal 16.44 11.17 7 68219 40467 79635695
Serratia infection 16.43 11.17 13 68213 1763 79674399
Oedematous pancreatitis 16.39 11.17 11 68215 1157 79675005
Plasmapheresis 16.37 11.17 9 68217 660 79675502
Infectious pleural effusion 16.28 11.17 18 68208 3726 79672436
Aggression 16.12 11.17 12 68214 50946 79625216
Abdominal wall abscess 16.09 11.17 11 68215 1192 79674970
Gastrointestinal mucosa hyperaemia 16.09 11.17 8 68218 477 79675685
Fungal sepsis 16.08 11.17 13 68213 1817 79674345
Dehiscence 16.03 11.17 6 68220 177 79675985
Hepatic fibrosis 15.98 11.17 25 68201 7255 79668907
Papilloedema 15.95 11.17 23 68203 6210 79669952
Depressed level of consciousness 15.95 11.17 37 68189 96615 79579547
Mean cell volume increased 15.90 11.17 23 68203 6230 79669932
Cognitive disorder 15.83 11.17 22 68204 69904 79606258
Cytomegalovirus mucocutaneous ulcer 15.78 11.17 5 68221 88 79676074
Aspartate aminotransferase increased 15.78 11.17 63 68163 138578 79537584
Neutropenia 15.71 11.17 339 67887 287371 79388791
Migraine 15.68 11.17 32 68194 87461 79588701
Pancreatitis necrotising 15.65 11.17 18 68208 3890 79672272
Blood albumin decreased 15.63 11.17 51 68175 24192 79651970
Platelet count decreased 15.57 11.17 100 68126 194564 79481598
Oral pain 15.54 11.17 4 68222 31794 79644368
Gastrointestinal fungal infection 15.53 11.17 8 68218 514 79675648
Hemianopia heteronymous 15.53 11.17 5 68221 93 79676069
Brain herniation 15.51 11.17 25 68201 7438 79668724
Coronary artery disease 15.43 11.17 20 68206 65454 79610708
Psoriatic arthropathy 15.31 11.17 27 68199 77972 79598190
General physical health deterioration 15.29 11.17 156 68070 275082 79401080
Arteriosclerosis 15.21 11.17 42 68184 18185 79657977
Femur fracture 15.21 11.17 7 68219 38645 79637517
Lip swelling 15.20 11.17 8 68218 40903 79635259
Accidental exposure to product 15.19 11.17 4 68222 31318 79644844
Drug level above therapeutic 15.18 11.17 27 68199 8696 79667466
Bacterial colitis 15.14 11.17 5 68221 101 79676061
Disseminated mycobacterium avium complex infection 15.04 11.17 6 68220 211 79675951
Bile duct stenosis 14.98 11.17 13 68213 2003 79674159
Heart rate increased 14.94 11.17 53 68173 120671 79555491
Diarrhoea infectious 14.94 11.17 12 68214 1662 79674500
Hyperparathyroidism 14.89 11.17 16 68210 3208 79672954
Ocular hyperaemia 14.88 11.17 3 68223 28203 79647959
Glomerular filtration rate decreased 14.86 11.17 48 68178 22654 79653508
Cardiac failure 14.83 11.17 75 68151 154767 79521395
Tularaemia 14.83 11.17 5 68221 108 79676054
Intracranial pressure increased 14.80 11.17 26 68200 8296 79667866
Cardiac murmur functional 14.79 11.17 4 68222 39 79676123
Lymphoproliferative disorder 14.78 11.17 21 68205 5594 79670568
Legionella infection 14.77 11.17 9 68217 801 79675361
Genital herpes simplex 14.76 11.17 7 68219 376 79675786
Palmar-plantar erythrodysaesthesia syndrome 14.68 11.17 5 68221 33129 79643033
Tuberculoma of central nervous system 14.65 11.17 8 68218 579 79675583
Metastatic malignant melanoma 14.63 11.17 15 68211 2848 79673314
Tinnitus 14.60 11.17 10 68216 44323 79631839
Myopathy toxic 14.59 11.17 10 68216 1088 79675074
Normocytic anaemia 14.57 11.17 18 68208 4189 79671973
Basal cell carcinoma 14.55 11.17 67 68159 37308 79638854
Hypothyroidism 14.54 11.17 14 68212 52378 79623784
Splenic abscess 14.53 11.17 8 68218 588 79675574
Incisional hernia 14.51 11.17 14 68212 2472 79673690
Hypertriglyceridaemia 14.46 11.17 33 68193 12707 79663455
Sebaceous carcinoma 14.37 11.17 5 68221 119 79676043
Feeling hot 14.33 11.17 18 68208 59716 79616446
Therapy change 14.32 11.17 24 68202 7375 79668787
Endocarditis viral 14.30 11.17 3 68223 8 79676154
Infective tenosynovitis 14.29 11.17 7 68219 404 79675758
Scopulariopsis infection 14.25 11.17 5 68221 122 79676040
Oropharyngeal pain 14.22 11.17 47 68179 109306 79566856
Hyperamylasaemia 14.20 11.17 10 68216 1137 79675025
Complications of transplanted liver 14.18 11.17 7 68219 411 79675751
Granulomatous dermatitis 14.13 11.17 7 68219 414 79675748
Drug withdrawal syndrome 14.11 11.17 6 68220 34712 79641450
Conjunctival neoplasm 14.04 11.17 3 68223 9 79676153
Sinus tachycardia 14.04 11.17 7 68219 36901 79639261
Nephrotic syndrome 13.87 11.17 30 68196 11144 79665018
Skin exfoliation 13.86 11.17 16 68210 55084 79621078
Full blood count decreased 13.85 11.17 3 68223 26816 79649346
CD8 lymphocytes decreased 13.80 11.17 6 68220 263 79675899
Microangiopathic haemolytic anaemia 13.74 11.17 11 68215 1516 79674646
Pseudomonal bacteraemia 13.72 11.17 15 68211 3067 79673095
Peliosis hepatis 13.67 11.17 5 68221 138 79676024
Infective scleritis 13.61 11.17 4 68222 54 79676108
Large intestine perforation 13.61 11.17 35 68191 14532 79661630
Meningitis histoplasma 13.58 11.17 3 68223 11 79676151
Urine output decreased 13.56 11.17 40 68186 17982 79658180
Venous stenosis 13.52 11.17 6 68220 276 79675886
Cytomegalovirus gastroenteritis 13.49 11.17 7 68219 457 79675705
Red blood cell burr cells present 13.47 11.17 4 68222 56 79676106
Ureteric obstruction 13.47 11.17 14 68212 2702 79673460
Angioedema 13.46 11.17 28 68198 76007 79600155
Vision blurred 13.44 11.17 46 68180 105852 79570310
Anaphylactic shock 13.43 11.17 7 68219 35989 79640173
Capillaritis 13.42 11.17 6 68220 281 79675881
Mycobacterium marinum infection 13.42 11.17 7 68219 462 79675700
Hypervolaemia 13.40 11.17 72 68154 42618 79633544
Meningitis 13.38 11.17 27 68199 9555 79666607
Acinetobacter bacteraemia 13.38 11.17 6 68220 283 79675879
Systemic inflammatory response syndrome 13.35 11.17 30 68196 11435 79664727
Bronchial anastomosis complication 13.35 11.17 4 68222 58 79676104
Disseminated cytomegaloviral infection 13.33 11.17 7 68219 468 79675694
Post procedural urine leak 13.31 11.17 5 68221 149 79676013
BK polyomavirus test positive 13.31 11.17 5 68221 149 79676013
Prescribed overdose 13.22 11.17 8 68218 37875 79638287
Gastrointestinal ulcer perforation 13.22 11.17 4 68222 60 79676102
Pneumomediastinum 13.21 11.17 16 68210 3651 79672511
Bone pain 13.16 11.17 17 68209 55725 79620437
Joint range of motion decreased 13.14 11.17 6 68220 33276 79642886
Pancreas transplant 13.10 11.17 4 68222 62 79676100
Sebaceous gland disorder 13.04 11.17 4 68222 63 79676099
Influenza like illness 13.04 11.17 26 68200 71681 79604481
Joint tuberculosis 12.98 11.17 5 68221 160 79676002
Sopor 12.95 11.17 6 68220 33004 79643158
Retinal artery occlusion 12.90 11.17 15 68211 3279 79672883
Orf 12.87 11.17 4 68222 66 79676096
Myeloma cast nephropathy 12.86 11.17 5 68221 164 79675998
Small intestine gangrene 12.83 11.17 3 68223 15 79676147
Graft versus host disease in eye 12.82 11.17 6 68220 313 79675849
Upper gastrointestinal haemorrhage 12.77 11.17 10 68216 41370 79634792
Pneumonia influenzal 12.69 11.17 14 68212 2890 79673272
Stevens-Johnson syndrome 12.68 11.17 9 68217 39157 79637005
Bronchitis 12.67 11.17 63 68163 130581 79545581
Hepatic cyst infection 12.66 11.17 5 68221 171 79675991
Viral sepsis 12.66 11.17 5 68221 171 79675991
Genital herpes 12.66 11.17 12 68214 2072 79674090
Muscular weakness 12.63 11.17 83 68143 160646 79515516
Adverse event 12.60 11.17 20 68206 60194 79615968
Chest discomfort 12.58 11.17 68 68158 137976 79538186
Renal tubular dysfunction 12.57 11.17 8 68218 769 79675393
Enteritis 12.57 11.17 34 68192 14549 79661613
Intentional self-injury 12.55 11.17 6 68220 32413 79643749
Narrow anterior chamber angle 12.50 11.17 5 68221 177 79675985
Forced vital capacity decreased 12.47 11.17 11 68215 1732 79674430
Urinary tract infection viral 12.44 11.17 4 68222 74 79676088
Orbital apex syndrome 12.39 11.17 4 68222 75 79676087
Dyskinesia 12.38 11.17 12 68214 44761 79631401
Intestinal ulcer perforation 12.37 11.17 3 68223 18 79676144
Muscle abscess 12.35 11.17 9 68217 1079 79675083
Anaphylactic reaction 12.31 11.17 34 68192 83709 79592453
Encephalitis fungal 12.27 11.17 5 68221 186 79675976
Pulmonary alveolar haemorrhage 12.26 11.17 29 68197 11428 79664734
Hypocholesterolaemia 12.22 11.17 5 68221 188 79675974
Scleroderma 12.20 11.17 19 68207 5491 79670671
Leiomyosarcoma 12.19 11.17 6 68220 350 79675812
Paracoccidioides infection 12.15 11.17 4 68222 80 79676082
Hypoalbuminaemia 12.15 11.17 43 68183 21254 79654908
Thyroid gland abscess 12.06 11.17 4 68222 82 79676080
Cytokine release syndrome 12.02 11.17 8 68218 35990 79640172
Neutrophil Pelger-Huet anomaly present 12.02 11.17 6 68220 361 79675801
Purulent pericarditis 12.01 11.17 4 68222 83 79676079
Arteritis infective 12.01 11.17 4 68222 83 79676079
Epstein-Barr virus test positive 11.98 11.17 9 68217 1130 79675032
Pregnancy 11.98 11.17 4 68222 26847 79649315
Intra-abdominal haemorrhage 11.98 11.17 17 68209 4523 79671639
Arnold-Chiari malformation 11.97 11.17 5 68221 198 79675964
Splenorenal shunt 11.97 11.17 3 68223 21 79676141
Salmonellosis 11.97 11.17 11 68215 1827 79674335
Brain compression 11.93 11.17 7 68219 581 79675581
Encapsulating peritoneal sclerosis 11.90 11.17 8 68218 843 79675319
Ill-defined disorder 11.88 11.17 24 68202 65851 79610311
Leuconostoc infection 11.85 11.17 3 68223 22 79676140
Rhinovirus infection 11.82 11.17 23 68203 7930 79668232
Diffuse alveolar damage 11.82 11.17 15 68211 3589 79672573
Cytomegalovirus myocarditis 11.74 11.17 3 68223 23 79676139
Road traffic accident 11.73 11.17 12 68214 43652 79632510
Large intestine infection 11.70 11.17 14 68212 3155 79673007
High density lipoprotein decreased 11.66 11.17 17 68209 4638 79671524
Malignant ascites 11.62 11.17 9 68217 1183 79674979
Acute respiratory failure 11.61 11.17 89 68137 59452 79616710
Haemodynamic instability 11.60 11.17 37 68189 17345 79658817
Mycobacterium fortuitum infection 11.59 11.17 5 68221 215 79675947
Glomerulonephritis membranoproliferative 11.56 11.17 7 68219 616 79675546
Herpes oesophagitis 11.54 11.17 6 68220 393 79675769
Biliary dilatation 11.44 11.17 13 68213 2773 79673389
Bacteroides bacteraemia 11.43 11.17 4 68222 97 79676065
Irritability 11.41 11.17 11 68215 41133 79635029
Klebsiella sepsis 11.40 11.17 14 68212 3238 79672924
Drug ineffective for unapproved indication 11.38 11.17 79 68147 51159 79625003
Meningitis enterococcal 11.35 11.17 4 68222 99 79676063
Viral skin infection 11.31 11.17 4 68222 100 79676062
Cutaneous tuberculosis 11.31 11.17 5 68221 228 79675934
Bone marrow granuloma 11.31 11.17 3 68223 27 79676135
Complications of transplanted pancreas 11.31 11.17 3 68223 27 79676135
Adverse drug reaction 11.29 11.17 25 68201 66367 79609795
Pulmonary mass 11.26 11.17 52 68174 28982 79647180
Total lung capacity abnormal 11.25 11.17 5 68221 231 79675931
Periorbital cellulitis 11.22 11.17 8 68218 927 79675235
Conjunctivitis 11.18 11.17 4 68222 25711 79650451

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AA06 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Selective immunosuppressants
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000903 Antibiotics, Antineoplastic
MeSH PA D000904 Antibiotics, Antitubercular
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000995 Antitubercular Agents
MeSH PA D004791 Enzyme Inhibitors
FDA EPC N0000175613 Antimetabolite Immunosuppressant
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:53746 EC 1.1.1.205 inhibitor
CHEBI has role CHEBI:25442 mycotoxins
CHEBI has role CHEBI:33281 antibiotics
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:76964 Penicillium metabolites
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:149553 anticoronaviral drug

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Prevention of Liver Transplant Rejection indication
Prevention of Cardiac Transplant Rejection indication
Prevention of Kidney Transplant Rejection indication
Prevention of Lung Transplant Rejection off-label use
Herpes zoster contraindication 4740000 DOID:8536
Progressive multifocal leukoencephalopathy contraindication 22255007 DOID:643
Cytomegalovirus infection contraindication 28944009
Constitutional aplastic anemia contraindication 28975000 DOID:1342
Gastrointestinal ulcer contraindication 40845000
Gastrointestinal perforation contraindication 51875005
Acute nephropathy contraindication 58574008
Acute infectious disease contraindication 63171007
Gastrointestinal hemorrhage contraindication 74474003
Herpes simplex contraindication 88594005 DOID:8566
Malignant lymphoma contraindication 118600007 DOID:0060058
Deficiency of hypoxanthine phosphoribosyltransferase contraindication 124275001
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Primary malignant neoplasm contraindication 372087000
Malignant neoplasm of skin contraindication 372130007 DOID:4159
Breastfeeding (mother) contraindication 413712001
Opportunistic Fungal Infection contraindication
BK Polyomavirus Reactivation Nephropathy contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.67 acidic
pKa2 11.03 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Inosine-5'-monophosphate dehydrogenase (IMPDH) Enzyme INHIBITOR IC50 4.70 CHEMBL CHEMBL
Inosine-5'-monophosphate dehydrogenase 1 Enzyme Ki 7.48 CHEMBL
Inosine-5'-monophosphate dehydrogenase 2 Enzyme Ki 8.22 CHEMBL
Inosine-5'-monophosphate dehydrogenase Unclassified IC50 6.92 CHEMBL

External reference:

IDSource
4025608 VUID
N0000176078 NUI
D05095 KEGG_DRUG
4021418 VANDF
4025598 VANDF
4025608 VANDF
C0026933 UMLSCUI
CHEBI:168396 CHEBI
MOA PDB_CHEM_ID
CHEMBL866 ChEMBL_ID
DB01024 DRUGBANK_ID
CHEMBL2106643 ChEMBL_ID
D009173 MESH_DESCRIPTOR_UI
446541 PUBCHEM_CID
6832 IUPHAR_LIGAND_ID
2950 INN_ID
HU9DX48N0T UNII
265323 RXNORM
18132 MMSL
210716 MMSL
d05217 MMSL
005013 NDDF
009984 NDDF
409330005 SNOMEDCT_US
409331009 SNOMEDCT_US
426216009 SNOMEDCT_US
24280-93-1 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Myfortic HUMAN PRESCRIPTION DRUG LABEL 1 0078-0385 TABLET, DELAYED RELEASE 180 mg ORAL NDA 29 sections
Myfortic HUMAN PRESCRIPTION DRUG LABEL 1 0078-0385 TABLET, DELAYED RELEASE 180 mg ORAL NDA 29 sections
Myfortic HUMAN PRESCRIPTION DRUG LABEL 1 0078-0385 TABLET, DELAYED RELEASE 180 mg ORAL NDA 29 sections
Myfortic HUMAN PRESCRIPTION DRUG LABEL 1 0078-0386 TABLET, DELAYED RELEASE 360 mg ORAL NDA 29 sections
Myfortic HUMAN PRESCRIPTION DRUG LABEL 1 0078-0386 TABLET, DELAYED RELEASE 360 mg ORAL NDA 29 sections
Myfortic HUMAN PRESCRIPTION DRUG LABEL 1 0078-0386 TABLET, DELAYED RELEASE 360 mg ORAL NDA 29 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0378-4201 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 29 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0378-4201 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 29 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0378-4201 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 29 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0378-4202 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 29 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0378-4202 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 29 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0378-4202 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 29 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0904-6785 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0904-6785 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0904-6786 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0904-6786 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 16729-189 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 27 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 16729-189 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 27 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 16729-189 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 27 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 16729-261 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 27 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 16729-261 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 27 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 16729-261 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 27 sections
mycophenolic acid HUMAN PRESCRIPTION DRUG LABEL 1 24979-160 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 29 sections
mycophenolic acid HUMAN PRESCRIPTION DRUG LABEL 1 24979-160 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 29 sections
mycophenolic acid HUMAN PRESCRIPTION DRUG LABEL 1 24979-161 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 29 sections
mycophenolic acid HUMAN PRESCRIPTION DRUG LABEL 1 24979-161 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 29 sections
MYCOPHENOLIC ACID Human Prescription Drug Label 1 50090-6492 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 28 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 50268-559 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 50268-559 TABLET, DELAYED RELEASE 180 mg ORAL ANDA 23 sections
Mycophenolic Acid HUMAN PRESCRIPTION DRUG LABEL 1 50268-560 TABLET, DELAYED RELEASE 360 mg ORAL ANDA 23 sections