Stem definition | Drug id | CAS RN |
---|---|---|
opioid receptor antagonists/agonists, morphinan derivates | 1845 | 57-27-2 |
Dose | Unit | Route |
---|---|---|
0.10 | g | O |
30 | mg | P |
30 | mg | R |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 57.14 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 4 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 5.85 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 24 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 2.30 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 26 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.65 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 2 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
None | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 6611.40 | 9.57 | 6593 | 209156 | 304094 | 62969179 |
Drug abuse | 1097.64 | 9.57 | 1292 | 214457 | 71226 | 63202047 |
Toxicity to various agents | 956.42 | 9.57 | 2392 | 213357 | 244858 | 63028415 |
Sedation | 475.19 | 9.57 | 622 | 215127 | 38187 | 63235086 |
Depressed level of consciousness | 467.49 | 9.57 | 792 | 214957 | 61286 | 63211987 |
Overdose | 453.96 | 9.57 | 1123 | 214626 | 113955 | 63159318 |
Death | 446.98 | 9.57 | 2474 | 213275 | 371907 | 62901366 |
Respiratory depression | 443.40 | 9.57 | 370 | 215379 | 13345 | 63259928 |
Constipation | 395.91 | 9.57 | 1663 | 214086 | 223280 | 63049993 |
Respiratory arrest | 382.35 | 9.57 | 512 | 215237 | 32133 | 63241140 |
Sedation complication | 374.25 | 9.57 | 337 | 215412 | 13485 | 63259788 |
Creatinine renal clearance decreased | 350.68 | 9.57 | 350 | 215399 | 15958 | 63257315 |
Accidental overdose | 343.53 | 9.57 | 410 | 215339 | 22899 | 63250374 |
Drug dependence | 299.03 | 9.57 | 392 | 215357 | 24091 | 63249182 |
Miosis | 294.57 | 9.57 | 225 | 215524 | 7128 | 63266145 |
Alopecia | 281.82 | 9.57 | 445 | 215304 | 337091 | 62936182 |
Systemic lupus erythematosus | 278.14 | 9.57 | 184 | 215565 | 208734 | 63064539 |
Blood calcium decreased | 266.61 | 9.57 | 386 | 215363 | 26065 | 63247208 |
Pemphigus | 262.39 | 9.57 | 149 | 215600 | 183577 | 63089696 |
Coma | 241.96 | 9.57 | 617 | 215132 | 63747 | 63209526 |
Somnolence | 237.92 | 9.57 | 1218 | 214531 | 177467 | 63095806 |
Glossodynia | 234.76 | 9.57 | 160 | 215589 | 178716 | 63094557 |
Orthostatic hypotension | 231.71 | 9.57 | 430 | 215319 | 35730 | 63237543 |
Completed suicide | 209.46 | 9.57 | 1015 | 214734 | 144658 | 63128615 |
Hypotension | 205.67 | 9.57 | 1607 | 214142 | 270997 | 63002276 |
Cardiac arrest | 201.31 | 9.57 | 732 | 215017 | 91813 | 63181460 |
Arthropathy | 201.10 | 9.57 | 304 | 215445 | 234488 | 63038785 |
Bradypnoea | 200.72 | 9.57 | 134 | 215615 | 3416 | 63269857 |
Abdominal discomfort | 199.05 | 9.57 | 503 | 215246 | 320382 | 62952891 |
Drug withdrawal syndrome | 191.57 | 9.57 | 337 | 215412 | 26857 | 63246416 |
Vomiting | 179.85 | 9.57 | 2782 | 212967 | 556835 | 62716438 |
Cardio-respiratory arrest | 171.18 | 9.57 | 520 | 215229 | 59439 | 63213834 |
Contrast media allergy | 168.89 | 9.57 | 104 | 215645 | 2297 | 63270976 |
Cognitive disorder | 164.95 | 9.57 | 490 | 215259 | 55325 | 63217948 |
Unresponsive to stimuli | 161.60 | 9.57 | 356 | 215393 | 33460 | 63239813 |
Respiratory rate decreased | 156.82 | 9.57 | 115 | 215634 | 3420 | 63269853 |
Hand deformity | 155.15 | 9.57 | 188 | 215561 | 159269 | 63114004 |
Substance abuse | 153.94 | 9.57 | 129 | 215620 | 4678 | 63268595 |
Macular degeneration | 152.57 | 9.57 | 287 | 215462 | 24089 | 63249184 |
Swelling | 141.94 | 9.57 | 471 | 215278 | 274907 | 62998366 |
Hyperaesthesia | 141.82 | 9.57 | 167 | 215582 | 9191 | 63264082 |
Folliculitis | 136.82 | 9.57 | 35 | 215714 | 70282 | 63202991 |
Balance disorder | 135.04 | 9.57 | 607 | 215142 | 83815 | 63189458 |
Product dose omission issue | 131.15 | 9.57 | 386 | 215363 | 233927 | 63039346 |
Maternal exposure during delivery | 126.42 | 9.57 | 73 | 215676 | 1427 | 63271846 |
Muscle injury | 122.47 | 9.57 | 35 | 215714 | 65310 | 63207963 |
Pericarditis | 121.87 | 9.57 | 161 | 215588 | 131418 | 63141855 |
Fatigue | 118.93 | 9.57 | 2216 | 213533 | 885812 | 62387461 |
Arthralgia | 115.63 | 9.57 | 1309 | 214440 | 568401 | 62704872 |
Intestinal pseudo-obstruction | 115.01 | 9.57 | 58 | 215691 | 854 | 63272419 |
Myoclonus | 114.82 | 9.57 | 199 | 215550 | 15669 | 63257604 |
Irritable bowel syndrome | 114.50 | 9.57 | 69 | 215680 | 82343 | 63190930 |
Inadequate analgesia | 111.22 | 9.57 | 87 | 215662 | 2856 | 63270417 |
Sinusitis | 109.77 | 9.57 | 398 | 215351 | 226255 | 63047018 |
Anti-cyclic citrullinated peptide antibody positive | 107.82 | 9.57 | 142 | 215607 | 116070 | 63157203 |
Wound | 105.73 | 9.57 | 250 | 215499 | 163013 | 63110260 |
Device expulsion | 104.67 | 9.57 | 3 | 215746 | 34919 | 63238354 |
Poisoning | 104.65 | 9.57 | 176 | 215573 | 13524 | 63259749 |
Duodenal ulcer perforation | 104.06 | 9.57 | 86 | 215663 | 87123 | 63186150 |
Ill-defined disorder | 100.83 | 9.57 | 78 | 215671 | 81677 | 63191596 |
Exposure via ingestion | 99.27 | 9.57 | 81 | 215668 | 2828 | 63270445 |
Drug ineffective | 98.09 | 9.57 | 2755 | 212994 | 1042010 | 62231263 |
Sleep disorder due to general medical condition, insomnia type | 97.80 | 9.57 | 28 | 215721 | 52189 | 63221084 |
Weight increased | 96.42 | 9.57 | 507 | 215242 | 260285 | 63012988 |
COVID-19 | 96.20 | 9.57 | 147 | 215602 | 112956 | 63160317 |
Poisoning deliberate | 95.00 | 9.57 | 151 | 215598 | 11067 | 63262206 |
Helicobacter infection | 93.85 | 9.57 | 106 | 215643 | 92679 | 63180594 |
Mental status changes | 93.59 | 9.57 | 322 | 215427 | 39277 | 63233996 |
Malignant neoplasm progression | 91.76 | 9.57 | 534 | 215215 | 81587 | 63191686 |
Off label use | 91.01 | 9.57 | 1680 | 214069 | 672782 | 62600491 |
Asphyxia | 88.23 | 9.57 | 107 | 215642 | 6074 | 63267199 |
Gastrointestinal disorder | 88.16 | 9.57 | 197 | 215552 | 131042 | 63142231 |
Hypoxia | 86.82 | 9.57 | 418 | 215331 | 59374 | 63213899 |
Contraindicated product administered | 86.80 | 9.57 | 412 | 215337 | 217236 | 63056037 |
Impaired healing | 86.51 | 9.57 | 134 | 215615 | 102408 | 63170865 |
Discomfort | 84.97 | 9.57 | 288 | 215461 | 167086 | 63106187 |
Drug abuser | 84.55 | 9.57 | 74 | 215675 | 2849 | 63270424 |
White blood cell count abnormal | 84.17 | 9.57 | 105 | 215644 | 6137 | 63267136 |
Drug screen positive | 83.81 | 9.57 | 81 | 215668 | 3548 | 63269725 |
Nasopharyngitis | 83.35 | 9.57 | 514 | 215235 | 253743 | 63019530 |
Soft tissue disorder | 82.58 | 9.57 | 88 | 215661 | 4334 | 63268939 |
Delirium | 81.24 | 9.57 | 364 | 215385 | 50177 | 63223096 |
Mobility decreased | 80.78 | 9.57 | 695 | 215054 | 120464 | 63152809 |
Apnoea | 80.72 | 9.57 | 117 | 215632 | 7905 | 63265368 |
Retinitis | 80.01 | 9.57 | 102 | 215647 | 6094 | 63267179 |
Injection site erythema | 79.86 | 9.57 | 99 | 215650 | 83075 | 63190198 |
Drug diversion | 79.53 | 9.57 | 46 | 215703 | 902 | 63272371 |
Maternal exposure during pregnancy | 78.45 | 9.57 | 433 | 215316 | 219629 | 63053644 |
Hallucination | 77.99 | 9.57 | 381 | 215368 | 54436 | 63218837 |
Acute chest syndrome | 77.41 | 9.57 | 43 | 215706 | 778 | 63272495 |
Anterior spinal artery syndrome | 77.30 | 9.57 | 25 | 215724 | 100 | 63273173 |
Intentional product misuse | 75.93 | 9.57 | 408 | 215341 | 60509 | 63212764 |
Respiratory failure | 71.45 | 9.57 | 591 | 215158 | 101267 | 63172006 |
Rash | 68.86 | 9.57 | 1419 | 214330 | 559452 | 62713821 |
Abortion spontaneous | 67.70 | 9.57 | 38 | 215711 | 47157 | 63226116 |
Contusion | 63.99 | 9.57 | 277 | 215472 | 149767 | 63123506 |
Blister | 62.76 | 9.57 | 228 | 215521 | 129586 | 63143687 |
Injection site pain | 62.74 | 9.57 | 228 | 215521 | 129572 | 63143701 |
Dilatation intrahepatic duct acquired | 62.15 | 9.57 | 35 | 215714 | 651 | 63272622 |
Aspiration | 62.07 | 9.57 | 123 | 215626 | 10728 | 63262545 |
Acidosis | 60.28 | 9.57 | 124 | 215625 | 11109 | 63262164 |
Urinary retention | 60.28 | 9.57 | 233 | 215516 | 30068 | 63243205 |
Injection site reaction | 60.12 | 9.57 | 66 | 215683 | 58458 | 63214815 |
Nausea | 59.41 | 9.57 | 3506 | 212243 | 850965 | 62422308 |
Hypercapnia | 57.27 | 9.57 | 81 | 215668 | 5350 | 63267923 |
Joint swelling | 56.81 | 9.57 | 778 | 214971 | 326888 | 62946385 |
Obliterative bronchiolitis | 56.54 | 9.57 | 51 | 215698 | 2044 | 63271229 |
Withdrawal syndrome | 55.71 | 9.57 | 172 | 215577 | 19825 | 63253448 |
Injection site pruritus | 53.18 | 9.57 | 45 | 215704 | 45071 | 63228202 |
Injection site swelling | 53.02 | 9.57 | 50 | 215699 | 47522 | 63225751 |
Sphincter of Oddi dysfunction | 51.97 | 9.57 | 26 | 215723 | 376 | 63272897 |
Peripheral swelling | 51.82 | 9.57 | 616 | 215133 | 265326 | 63007947 |
Condition aggravated | 51.25 | 9.57 | 1011 | 214738 | 401206 | 62872067 |
Hepatic enzyme increased | 50.85 | 9.57 | 441 | 215308 | 201887 | 63071386 |
Abdominal pain | 50.76 | 9.57 | 1331 | 214418 | 292125 | 62981148 |
Vaginal flatulence | 50.28 | 9.57 | 59 | 215690 | 3234 | 63270039 |
Bone erosion | 49.92 | 9.57 | 153 | 215596 | 17564 | 63255709 |
Drug withdrawal syndrome neonatal | 49.10 | 9.57 | 47 | 215702 | 2034 | 63271239 |
Anaphylactic reaction | 47.67 | 9.57 | 386 | 215363 | 65714 | 63207559 |
Lethargy | 47.07 | 9.57 | 339 | 215410 | 55668 | 63217605 |
Narcotic bowel syndrome | 46.32 | 9.57 | 18 | 215731 | 135 | 63273138 |
Respiratory acidosis | 45.72 | 9.57 | 82 | 215667 | 6633 | 63266640 |
Product use issue | 45.20 | 9.57 | 505 | 215244 | 220015 | 63053258 |
Therapeutic product effect decreased | 44.67 | 9.57 | 430 | 215319 | 192757 | 63080516 |
Exostosis | 44.63 | 9.57 | 148 | 215601 | 17714 | 63255559 |
Gangrene | 44.57 | 9.57 | 77 | 215672 | 6046 | 63267227 |
Joint dislocation | 44.53 | 9.57 | 153 | 215596 | 18647 | 63254626 |
Neutropenic sepsis | 44.51 | 9.57 | 140 | 215609 | 16298 | 63256975 |
Visceral congestion | 43.98 | 9.57 | 22 | 215727 | 318 | 63272955 |
Cardiac failure congestive | 43.58 | 9.57 | 164 | 215585 | 92269 | 63181004 |
Pregnancy | 43.10 | 9.57 | 37 | 215712 | 36799 | 63236474 |
Nasal congestion | 42.91 | 9.57 | 100 | 215649 | 65560 | 63207713 |
Cholestasis | 40.73 | 9.57 | 203 | 215546 | 29231 | 63244042 |
Diarrhoea | 40.53 | 9.57 | 2003 | 213746 | 713363 | 62559910 |
Radiculopathy | 40.39 | 9.57 | 90 | 215659 | 8521 | 63264752 |
Female genital tract fistula | 40.04 | 9.57 | 83 | 215666 | 7476 | 63265797 |
Confusional state | 39.94 | 9.57 | 1069 | 214680 | 235311 | 63037962 |
Psoriatic arthropathy | 39.59 | 9.57 | 168 | 215581 | 91352 | 63181921 |
No adverse event | 37.97 | 9.57 | 51 | 215698 | 41354 | 63231919 |
Colitis microscopic | 37.66 | 9.57 | 92 | 215657 | 9247 | 63264026 |
Synovitis | 37.14 | 9.57 | 431 | 215318 | 186487 | 63086786 |
Pulseless electrical activity | 36.85 | 9.57 | 80 | 215669 | 7441 | 63265832 |
Rhythm idioventricular | 36.75 | 9.57 | 18 | 215731 | 248 | 63273025 |
Proctitis | 36.48 | 9.57 | 66 | 215683 | 5375 | 63267898 |
Accidental death | 36.33 | 9.57 | 39 | 215710 | 1937 | 63271336 |
Hypersensitivity | 35.65 | 9.57 | 741 | 215008 | 291944 | 62981329 |
Ventilation perfusion mismatch | 35.32 | 9.57 | 22 | 215727 | 496 | 63272777 |
Iodine allergy | 35.31 | 9.57 | 26 | 215723 | 778 | 63272495 |
Agitation | 35.31 | 9.57 | 334 | 215415 | 59423 | 63213850 |
Oxygen saturation decreased | 34.87 | 9.57 | 457 | 215292 | 88128 | 63185145 |
Stomatitis | 34.55 | 9.57 | 303 | 215446 | 138422 | 63134851 |
Cough | 34.52 | 9.57 | 745 | 215004 | 291998 | 62981275 |
Sepsis | 34.27 | 9.57 | 720 | 215029 | 152403 | 63120870 |
Foetal megacystis | 34.16 | 9.57 | 10 | 215739 | 26 | 63273247 |
Plasma cell myeloma | 34.12 | 9.57 | 224 | 215525 | 35681 | 63237592 |
Accidental exposure to product by child | 34.10 | 9.57 | 30 | 215719 | 1163 | 63272110 |
Hepatic cirrhosis | 33.81 | 9.57 | 170 | 215579 | 24564 | 63248709 |
Mucosal inflammation | 33.81 | 9.57 | 274 | 215475 | 46654 | 63226619 |
Injection site rash | 33.57 | 9.57 | 11 | 215738 | 18798 | 63254475 |
Hospitalisation | 33.32 | 9.57 | 162 | 215587 | 84919 | 63188354 |
Intentional product use issue | 32.90 | 9.57 | 277 | 215472 | 127615 | 63145658 |
Skin candida | 32.80 | 9.57 | 34 | 215715 | 1621 | 63271652 |
Therapy interrupted | 31.81 | 9.57 | 38 | 215711 | 32417 | 63240856 |
Pancreatic fibrosis | 31.35 | 9.57 | 12 | 215737 | 86 | 63273187 |
Wrong technique in product usage process | 31.11 | 9.57 | 108 | 215641 | 62232 | 63211041 |
Tonsillar disorder | 30.98 | 9.57 | 28 | 215721 | 1125 | 63272148 |
Spinal cord injury | 30.76 | 9.57 | 25 | 215724 | 868 | 63272405 |
Brain oedema | 30.59 | 9.57 | 112 | 215637 | 14083 | 63259190 |
Post procedural complication | 30.52 | 9.57 | 127 | 215622 | 16947 | 63256326 |
Systemic mastocytosis | 30.37 | 9.57 | 14 | 215735 | 167 | 63273106 |
Sopor | 30.16 | 9.57 | 19 | 215730 | 22145 | 63251128 |
Pulmonary oedema | 30.11 | 9.57 | 302 | 215447 | 54571 | 63218702 |
Arterial occlusive disease | 29.91 | 9.57 | 64 | 215685 | 5894 | 63267379 |
Pneumonia viral | 29.80 | 9.57 | 76 | 215673 | 7846 | 63265427 |
Dyspnoea exertional | 29.73 | 9.57 | 105 | 215644 | 60197 | 63213076 |
Arthritis | 29.24 | 9.57 | 555 | 215194 | 115366 | 63157907 |
Toxicologic test abnormal | 28.74 | 9.57 | 22 | 215727 | 699 | 63272574 |
Pruritus allergic | 28.69 | 9.57 | 31 | 215718 | 1551 | 63271722 |
Implant site extravasation | 28.61 | 9.57 | 19 | 215730 | 480 | 63272793 |
Coronary artery disease | 28.56 | 9.57 | 41 | 215708 | 32336 | 63240937 |
Treatment failure | 28.51 | 9.57 | 490 | 215259 | 198553 | 63074720 |
Full blood count abnormal | 28.14 | 9.57 | 40 | 215709 | 31677 | 63241596 |
Bradycardia | 28.08 | 9.57 | 376 | 215373 | 72851 | 63200422 |
Dizziness | 28.06 | 9.57 | 1185 | 214564 | 428740 | 62844533 |
Cyanosis | 27.98 | 9.57 | 123 | 215626 | 16812 | 63256461 |
Rheumatoid factor positive | 27.94 | 9.57 | 170 | 215579 | 84236 | 63189037 |
Procedural pain | 27.92 | 9.57 | 146 | 215603 | 21423 | 63251850 |
Seronegative arthritis | 27.79 | 9.57 | 49 | 215700 | 3910 | 63269363 |
Infusion related reaction | 27.74 | 9.57 | 629 | 215120 | 244892 | 63028381 |
Transient ischaemic attack | 27.58 | 9.57 | 54 | 215695 | 37699 | 63235574 |
Hypoxic-ischaemic encephalopathy | 27.47 | 9.57 | 51 | 215698 | 4236 | 63269037 |
Heavy menstrual bleeding | 27.43 | 9.57 | 13 | 215736 | 17760 | 63255513 |
Vaginal discharge | 27.39 | 9.57 | 81 | 215668 | 9117 | 63264156 |
Sternal fracture | 27.37 | 9.57 | 36 | 215713 | 2218 | 63271055 |
Alveolitis | 27.15 | 9.57 | 41 | 215708 | 2874 | 63270399 |
Diffuse axonal injury | 26.87 | 9.57 | 11 | 215738 | 96 | 63273177 |
Colitis | 26.59 | 9.57 | 267 | 215482 | 48261 | 63225012 |
C-reactive protein abnormal | 26.42 | 9.57 | 75 | 215674 | 46021 | 63227252 |
Femur fracture | 26.16 | 9.57 | 65 | 215684 | 41691 | 63231582 |
Progressive multifocal leukoencephalopathy | 26.12 | 9.57 | 6 | 215743 | 12965 | 63260308 |
Rheumatic fever | 25.56 | 9.57 | 69 | 215680 | 43042 | 63230231 |
Drug tolerance | 25.45 | 9.57 | 66 | 215683 | 6883 | 63266390 |
Skin reaction | 25.42 | 9.57 | 109 | 215640 | 14740 | 63258533 |
Breast cancer metastatic | 25.21 | 9.57 | 94 | 215655 | 11924 | 63261349 |
Encephalopathy | 24.91 | 9.57 | 220 | 215529 | 38400 | 63234873 |
Allodynia | 24.22 | 9.57 | 21 | 215728 | 798 | 63272475 |
Multiple sclerosis relapse | 24.18 | 9.57 | 84 | 215665 | 48394 | 63224879 |
Laryngitis | 24.17 | 9.57 | 118 | 215631 | 16849 | 63256424 |
Hip arthroplasty | 24.14 | 9.57 | 82 | 215667 | 47564 | 63225709 |
Antinuclear antibody negative | 24.12 | 9.57 | 13 | 215736 | 221 | 63273052 |
Vascular resistance systemic decreased | 23.97 | 9.57 | 10 | 215739 | 92 | 63273181 |
Syncope | 23.95 | 9.57 | 269 | 215480 | 117116 | 63156157 |
Pupillary reflex impaired | 23.79 | 9.57 | 32 | 215717 | 2015 | 63271258 |
Small intestinal obstruction | 23.65 | 9.57 | 124 | 215625 | 18213 | 63255060 |
Anaesthesia | 23.59 | 9.57 | 16 | 215733 | 419 | 63272854 |
Administration site abscess | 23.43 | 9.57 | 7 | 215742 | 20 | 63273253 |
Foetal monitoring abnormal | 23.36 | 9.57 | 13 | 215736 | 236 | 63273037 |
Chronic spontaneous urticaria | 23.35 | 9.57 | 24 | 215725 | 1133 | 63272140 |
Respiratory distress | 23.26 | 9.57 | 196 | 215553 | 33755 | 63239518 |
Spinal epidural haemorrhage | 23.24 | 9.57 | 10 | 215739 | 100 | 63273173 |
Excessive eye blinking | 23.07 | 9.57 | 25 | 215724 | 1255 | 63272018 |
Foot deformity | 23.06 | 9.57 | 168 | 215581 | 27685 | 63245588 |
Cardiac output decreased | 23.02 | 9.57 | 22 | 215727 | 950 | 63272323 |
Administration site induration | 22.71 | 9.57 | 7 | 215742 | 23 | 63273250 |
Pulmonary congestion | 22.61 | 9.57 | 118 | 215631 | 17300 | 63255973 |
Breast cancer female | 22.38 | 9.57 | 9 | 215740 | 13550 | 63259723 |
Lupus-like syndrome | 22.24 | 9.57 | 107 | 215642 | 15188 | 63258085 |
Pupil fixed | 22.14 | 9.57 | 29 | 215720 | 1780 | 63271493 |
Libido increased | 22.05 | 9.57 | 25 | 215724 | 1320 | 63271953 |
Pulmonary toxicity | 22.02 | 9.57 | 3 | 215746 | 9452 | 63263821 |
Incoherent | 21.98 | 9.57 | 48 | 215701 | 4482 | 63268791 |
Interstitial lung disease | 21.92 | 9.57 | 122 | 215627 | 61786 | 63211487 |
Dry skin | 21.88 | 9.57 | 109 | 215640 | 56778 | 63216495 |
Therapy cessation | 21.87 | 9.57 | 44 | 215705 | 30413 | 63242860 |
Administration site discharge | 21.65 | 9.57 | 7 | 215742 | 28 | 63273245 |
Nervous system disorder | 21.58 | 9.57 | 123 | 215626 | 18643 | 63254630 |
Tenosynovitis | 21.43 | 9.57 | 10 | 215739 | 13785 | 63259488 |
Joint effusion | 21.38 | 9.57 | 16 | 215733 | 17044 | 63256229 |
Spinal cord compression | 21.33 | 9.57 | 45 | 215704 | 4103 | 63269170 |
Intentional self-injury | 21.24 | 9.57 | 34 | 215715 | 25653 | 63247620 |
Impaired work ability | 21.12 | 9.57 | 17 | 215732 | 17458 | 63255815 |
Headache | 21.10 | 9.57 | 1859 | 213890 | 631382 | 62641891 |
Catheter site granuloma | 21.10 | 9.57 | 5 | 215744 | 3 | 63273270 |
Personality disorder | 21.09 | 9.57 | 55 | 215694 | 5756 | 63267517 |
Product quality issue | 20.82 | 9.57 | 58 | 215691 | 35807 | 63237466 |
Total lung capacity decreased | 20.75 | 9.57 | 31 | 215718 | 2152 | 63271121 |
Peripheral nerve injury | 20.75 | 9.57 | 15 | 215734 | 436 | 63272837 |
Neuroendocrine tumour of the lung | 20.66 | 9.57 | 6 | 215743 | 15 | 63273258 |
Gallbladder cholesterolosis | 20.54 | 9.57 | 19 | 215730 | 787 | 63272486 |
Suicide attempt | 20.52 | 9.57 | 122 | 215627 | 60796 | 63212477 |
Dependence | 20.47 | 9.57 | 30 | 215719 | 2047 | 63271226 |
Eczema | 20.44 | 9.57 | 50 | 215699 | 32241 | 63241032 |
Hypoventilation | 20.43 | 9.57 | 48 | 215701 | 4706 | 63268567 |
Swollen joint count increased | 20.42 | 9.57 | 59 | 215690 | 35995 | 63237278 |
Complex regional pain syndrome | 20.33 | 9.57 | 32 | 215717 | 2325 | 63270948 |
Anaesthetic complication | 20.32 | 9.57 | 29 | 215720 | 1931 | 63271342 |
Blood phosphorus decreased | 20.28 | 9.57 | 46 | 215703 | 4407 | 63268866 |
Tendonitis | 20.27 | 9.57 | 22 | 215727 | 19593 | 63253680 |
Breast cancer | 20.20 | 9.57 | 90 | 215659 | 48293 | 63224980 |
Infective pulmonary exacerbation of cystic fibrosis | 20.06 | 9.57 | 3 | 215746 | 8814 | 63264459 |
Hyperhidrosis | 20.03 | 9.57 | 494 | 215255 | 107342 | 63165931 |
Urinary bladder rupture | 20.03 | 9.57 | 10 | 215739 | 144 | 63273129 |
Bronchopulmonary aspergillosis allergic | 19.96 | 9.57 | 31 | 215718 | 2227 | 63271046 |
Myalgia | 19.93 | 9.57 | 364 | 215385 | 146165 | 63127108 |
Cardiac failure | 19.92 | 9.57 | 200 | 215549 | 88942 | 63184331 |
Implant site discharge | 19.90 | 9.57 | 10 | 215739 | 146 | 63273127 |
Metastases to bone | 19.89 | 9.57 | 131 | 215618 | 20888 | 63252385 |
Administration site odour | 19.48 | 9.57 | 7 | 215742 | 41 | 63273232 |
Metastases to eye | 19.43 | 9.57 | 10 | 215739 | 154 | 63273119 |
Injection site warmth | 19.37 | 9.57 | 14 | 215735 | 15181 | 63258092 |
Infection | 19.35 | 9.57 | 612 | 215137 | 228561 | 63044712 |
Serotonin syndrome | 19.34 | 9.57 | 165 | 215584 | 28517 | 63244756 |
Injection site bruising | 19.33 | 9.57 | 75 | 215674 | 41835 | 63231438 |
Hepatocellular injury | 19.25 | 9.57 | 159 | 215590 | 27222 | 63246051 |
Chronic kidney disease | 19.22 | 9.57 | 84 | 215665 | 45314 | 63227959 |
Theft | 19.14 | 9.57 | 8 | 215741 | 74 | 63273199 |
Product name confusion | 19.14 | 9.57 | 8 | 215741 | 74 | 63273199 |
Faecaloma | 19.13 | 9.57 | 65 | 215684 | 7876 | 63265397 |
Blood immunoglobulin A decreased | 19.13 | 9.57 | 23 | 215726 | 1294 | 63271979 |
Knee arthroplasty | 19.09 | 9.57 | 107 | 215642 | 54099 | 63219174 |
Device difficult to use | 18.79 | 9.57 | 10 | 215739 | 12786 | 63260487 |
Calcium deficiency | 18.77 | 9.57 | 21 | 215728 | 1093 | 63272180 |
Suspected product tampering | 18.75 | 9.57 | 4 | 215745 | 0 | 63273273 |
Keratitis | 18.63 | 9.57 | 38 | 215711 | 3384 | 63269889 |
Coombs positive haemolytic anaemia | 18.59 | 9.57 | 13 | 215736 | 358 | 63272915 |
Basal ganglion degeneration | 18.59 | 9.57 | 14 | 215735 | 434 | 63272839 |
Liver injury | 18.44 | 9.57 | 125 | 215624 | 60395 | 63212878 |
Cardiopulmonary failure | 18.36 | 9.57 | 39 | 215710 | 3573 | 63269700 |
Palpitations | 18.35 | 9.57 | 271 | 215478 | 112499 | 63160774 |
Tissue infiltration | 18.35 | 9.57 | 16 | 215733 | 613 | 63272660 |
Nasal disorder | 18.26 | 9.57 | 34 | 215715 | 2830 | 63270443 |
Lung opacity | 18.23 | 9.57 | 36 | 215713 | 3132 | 63270141 |
Dyspnoea | 18.17 | 9.57 | 1969 | 213780 | 659344 | 62613929 |
Tachycardia | 18.14 | 9.57 | 528 | 215221 | 117628 | 63155645 |
Blood pH decreased | 18.14 | 9.57 | 32 | 215717 | 2555 | 63270718 |
Increased bronchial secretion | 18.12 | 9.57 | 26 | 215723 | 1740 | 63271533 |
Disease recurrence | 18.06 | 9.57 | 43 | 215706 | 27987 | 63245286 |
Myocardial infarction | 18.06 | 9.57 | 235 | 215514 | 99658 | 63173615 |
Gastrooesophageal reflux disease | 18.03 | 9.57 | 223 | 215526 | 95416 | 63177857 |
Polyarthritis | 17.99 | 9.57 | 6 | 215743 | 10140 | 63263133 |
Clonus | 17.99 | 9.57 | 45 | 215704 | 4591 | 63268682 |
Soft tissue injury | 17.96 | 9.57 | 25 | 215724 | 1627 | 63271646 |
Injection site urticaria | 17.89 | 9.57 | 13 | 215736 | 14060 | 63259213 |
Hypothermia | 17.62 | 9.57 | 92 | 215657 | 13489 | 63259784 |
Asthma | 17.62 | 9.57 | 316 | 215433 | 127245 | 63146028 |
Disease progression | 17.62 | 9.57 | 544 | 215205 | 122214 | 63151059 |
Feeling jittery | 17.54 | 9.57 | 12 | 215737 | 13391 | 63259882 |
Incubator therapy | 17.52 | 9.57 | 7 | 215742 | 57 | 63273216 |
Congenital pulmonary hypertension | 17.52 | 9.57 | 7 | 215742 | 57 | 63273216 |
Oral candidiasis | 17.45 | 9.57 | 135 | 215614 | 22663 | 63250610 |
Schizophrenia | 17.45 | 9.57 | 6 | 215743 | 9946 | 63263327 |
Sensory loss | 17.41 | 9.57 | 75 | 215674 | 10163 | 63263110 |
Central nervous system injury | 17.29 | 9.57 | 9 | 215740 | 142 | 63273131 |
Sleep disorder due to a general medical condition | 17.21 | 9.57 | 10 | 215739 | 12178 | 63261095 |
Injection site discolouration | 17.12 | 9.57 | 3 | 215746 | 7845 | 63265428 |
Patient uncooperative | 17.03 | 9.57 | 10 | 215739 | 202 | 63273071 |
Hostility | 16.97 | 9.57 | 26 | 215723 | 1846 | 63271427 |
Throat irritation | 16.97 | 9.57 | 68 | 215681 | 37579 | 63235694 |
Aplastic anaemia | 16.97 | 9.57 | 71 | 215678 | 9498 | 63263775 |
Lower respiratory tract infection | 16.96 | 9.57 | 332 | 215417 | 131975 | 63141298 |
Breakthrough pain | 16.86 | 9.57 | 21 | 215728 | 1225 | 63272048 |
Uveitis | 16.75 | 9.57 | 11 | 215738 | 12542 | 63260731 |
Administration site haemorrhage | 16.74 | 9.57 | 8 | 215741 | 104 | 63273169 |
Eye pain | 16.65 | 9.57 | 59 | 215690 | 33795 | 63239478 |
Urticaria thermal | 16.64 | 9.57 | 13 | 215736 | 426 | 63272847 |
Injection site cyst | 16.63 | 9.57 | 7 | 215742 | 66 | 63273207 |
Abortion induced | 16.58 | 9.57 | 7 | 215742 | 10235 | 63263038 |
Musculoskeletal stiffness | 16.57 | 9.57 | 489 | 215260 | 184129 | 63089144 |
Flushing | 16.55 | 9.57 | 169 | 215580 | 74918 | 63198355 |
Abnormal behaviour | 16.47 | 9.57 | 127 | 215622 | 21299 | 63251974 |
Hypoacusis | 16.41 | 9.57 | 36 | 215713 | 24115 | 63249158 |
Neuralgia | 16.37 | 9.57 | 147 | 215602 | 25779 | 63247494 |
Hallucination, visual | 16.32 | 9.57 | 117 | 215632 | 19181 | 63254092 |
Nodule | 16.31 | 9.57 | 29 | 215720 | 20997 | 63252276 |
Foetal heart rate abnormal | 16.20 | 9.57 | 15 | 215734 | 622 | 63272651 |
Sinus tachycardia | 16.04 | 9.57 | 139 | 215610 | 24129 | 63249144 |
Vascular malformation | 16.04 | 9.57 | 12 | 215737 | 368 | 63272905 |
Myelodysplastic syndrome | 16.01 | 9.57 | 20 | 215729 | 16734 | 63256539 |
Toxic leukoencephalopathy | 15.92 | 9.57 | 16 | 215733 | 735 | 63272538 |
Hallucination, tactile | 15.89 | 9.57 | 11 | 215738 | 298 | 63272975 |
Blood alkaline phosphatase increased | 15.80 | 9.57 | 219 | 215530 | 42748 | 63230525 |
Epidural haemorrhage | 15.79 | 9.57 | 8 | 215741 | 119 | 63273154 |
Drug resistance | 15.73 | 9.57 | 34 | 215715 | 22899 | 63250374 |
Disorientation | 15.71 | 9.57 | 204 | 215545 | 39248 | 63234025 |
Respiratory tract infection | 15.66 | 9.57 | 80 | 215669 | 41403 | 63231870 |
Back pain | 15.65 | 9.57 | 1070 | 214679 | 263075 | 63010198 |
Cancer pain | 15.60 | 9.57 | 34 | 215715 | 3171 | 63270102 |
Genital haemorrhage | 15.57 | 9.57 | 3 | 215746 | 7329 | 63265944 |
Drug tolerance increased | 15.54 | 9.57 | 10 | 215739 | 239 | 63273034 |
Antinuclear antibody positive | 15.52 | 9.57 | 4 | 215745 | 7995 | 63265278 |
Pituitary apoplexy | 15.44 | 9.57 | 8 | 215741 | 125 | 63273148 |
Skin cancer | 15.44 | 9.57 | 10 | 215739 | 11485 | 63261788 |
Loss of personal independence in daily activities | 15.41 | 9.57 | 235 | 215514 | 97055 | 63176218 |
Paranasal cyst | 15.31 | 9.57 | 12 | 215737 | 395 | 63272878 |
Infusion site pain | 15.24 | 9.57 | 21 | 215728 | 16848 | 63256425 |
Peptic ulcer perforation | 15.23 | 9.57 | 9 | 215740 | 184 | 63273089 |
Fear-related avoidance of activities | 15.22 | 9.57 | 8 | 215741 | 129 | 63273144 |
Epidural analgesia | 15.22 | 9.57 | 6 | 215743 | 47 | 63273226 |
Weaning failure | 15.21 | 9.57 | 12 | 215737 | 399 | 63272874 |
Liver function test abnormal | 15.14 | 9.57 | 239 | 215510 | 47942 | 63225331 |
Cerebrovascular accident | 15.11 | 9.57 | 267 | 215482 | 107757 | 63165516 |
Transplant rejection | 15.00 | 9.57 | 9 | 215740 | 10771 | 63262502 |
Post-traumatic neck syndrome | 14.99 | 9.57 | 26 | 215723 | 2048 | 63271225 |
Coma scale abnormal | 14.99 | 9.57 | 45 | 215704 | 5108 | 63268165 |
Tubulointerstitial nephritis | 14.95 | 9.57 | 28 | 215721 | 19875 | 63253398 |
Muscle twitching | 14.80 | 9.57 | 116 | 215633 | 19552 | 63253721 |
Myopathy | 14.67 | 9.57 | 10 | 215739 | 11181 | 63262092 |
Chronic sinusitis | 14.65 | 9.57 | 84 | 215665 | 12759 | 63260514 |
Dry eye | 14.61 | 9.57 | 80 | 215669 | 40681 | 63232592 |
Deformity | 14.59 | 9.57 | 11 | 215738 | 11673 | 63261600 |
Substance use | 14.56 | 9.57 | 13 | 215736 | 514 | 63272759 |
Terminal state | 14.44 | 9.57 | 27 | 215722 | 2255 | 63271018 |
Stroke volume increased | 14.38 | 9.57 | 4 | 215745 | 8 | 63273265 |
Liver disorder | 14.38 | 9.57 | 115 | 215634 | 53572 | 63219701 |
Hepatic function abnormal | 14.38 | 9.57 | 71 | 215678 | 37071 | 63236202 |
Suspected suicide | 14.30 | 9.57 | 52 | 215697 | 6516 | 63266757 |
Night sweats | 14.29 | 9.57 | 102 | 215647 | 48712 | 63224561 |
Rheumatic disorder | 14.29 | 9.57 | 32 | 215717 | 3040 | 63270233 |
Blood pressure diastolic abnormal | 14.28 | 9.57 | 17 | 215732 | 14525 | 63258748 |
Neuromuscular block prolonged | 14.25 | 9.57 | 13 | 215736 | 529 | 63272744 |
Documented hypersensitivity to administered product | 14.19 | 9.57 | 13 | 215736 | 532 | 63272741 |
Product storage error | 14.14 | 9.57 | 18 | 215731 | 14938 | 63258335 |
Infusion site granuloma | 14.06 | 9.57 | 3 | 215746 | 0 | 63273273 |
Agonal death struggle | 14.06 | 9.57 | 3 | 215746 | 0 | 63273273 |
Breath sounds abnormal | 14.01 | 9.57 | 74 | 215675 | 10899 | 63262374 |
White blood cell count decreased | 13.88 | 9.57 | 363 | 215386 | 138741 | 63134532 |
Thymus disorder | 13.82 | 9.57 | 10 | 215739 | 291 | 63272982 |
Pleuritic pain | 13.79 | 9.57 | 59 | 215690 | 7970 | 63265303 |
PO2 decreased | 13.77 | 9.57 | 21 | 215728 | 1485 | 63271788 |
Temperature regulation disorder | 13.74 | 9.57 | 49 | 215700 | 6083 | 63267190 |
Herpes simplex reactivation | 13.73 | 9.57 | 13 | 215736 | 555 | 63272718 |
Infusion | 13.69 | 9.57 | 8 | 215741 | 160 | 63273113 |
Pemphigoid | 13.63 | 9.57 | 4 | 215745 | 7340 | 63265933 |
Carcinoid tumour | 13.58 | 9.57 | 11 | 215738 | 380 | 63272893 |
Spinal cord paralysis | 13.54 | 9.57 | 5 | 215744 | 32 | 63273241 |
Onychomycosis | 13.53 | 9.57 | 5 | 215744 | 7927 | 63265346 |
Blood immunoglobulin M increased | 13.49 | 9.57 | 18 | 215731 | 1125 | 63272148 |
Posterior reversible encephalopathy syndrome | 13.44 | 9.57 | 103 | 215646 | 17242 | 63256031 |
Atrial fibrillation | 13.38 | 9.57 | 298 | 215451 | 116338 | 63156935 |
Dysphagia | 13.36 | 9.57 | 395 | 215354 | 88190 | 63185083 |
Blood calcium increased | 13.30 | 9.57 | 65 | 215684 | 9285 | 63263988 |
Hypohidrosis | 13.29 | 9.57 | 6 | 215743 | 68 | 63273205 |
Retrograde amnesia | 13.16 | 9.57 | 12 | 215737 | 488 | 63272785 |
Neuroblastoma | 12.98 | 9.57 | 6 | 215743 | 72 | 63273201 |
Hyperreflexia | 12.94 | 9.57 | 47 | 215702 | 5887 | 63267386 |
Muscle spasms | 12.93 | 9.57 | 418 | 215331 | 155732 | 63117541 |
Ear pain | 12.88 | 9.57 | 71 | 215678 | 36047 | 63237226 |
Mydriasis | 12.86 | 9.57 | 77 | 215672 | 11879 | 63261394 |
Occupational dermatitis | 12.81 | 9.57 | 5 | 215744 | 38 | 63273235 |
Suicidal ideation | 12.75 | 9.57 | 143 | 215606 | 62278 | 63210995 |
Skin fissures | 12.65 | 9.57 | 12 | 215737 | 11376 | 63261897 |
Rhinitis | 12.60 | 9.57 | 12 | 215737 | 11354 | 63261919 |
Iron deficiency anaemia | 12.58 | 9.57 | 31 | 215718 | 19938 | 63253335 |
Wheezing | 12.52 | 9.57 | 239 | 215510 | 95356 | 63177917 |
Laboratory test abnormal | 12.52 | 9.57 | 48 | 215701 | 26864 | 63246409 |
Neuroblastoma recurrent | 12.49 | 9.57 | 6 | 215743 | 79 | 63273194 |
Aspergillus infection | 12.37 | 9.57 | 6 | 215743 | 8087 | 63265186 |
Myoglobin urine | 12.37 | 9.57 | 4 | 215745 | 16 | 63273257 |
Rhinitis allergic | 12.29 | 9.57 | 13 | 215736 | 11714 | 63261559 |
Withdrawal catatonia | 12.17 | 9.57 | 6 | 215743 | 84 | 63273189 |
Myocardial fibrosis | 12.07 | 9.57 | 14 | 215735 | 758 | 63272515 |
Livedo reticularis | 12.07 | 9.57 | 26 | 215723 | 2406 | 63270867 |
Metastasis | 12.05 | 9.57 | 42 | 215707 | 5155 | 63268118 |
Metastases to spine | 12.05 | 9.57 | 31 | 215718 | 3218 | 63270055 |
Uterine enlargement | 12.04 | 9.57 | 18 | 215731 | 1250 | 63272023 |
Implant site infection | 12.01 | 9.57 | 16 | 215733 | 998 | 63272275 |
Type 2 diabetes mellitus | 12.01 | 9.57 | 149 | 215600 | 63719 | 63209554 |
Analgesic therapy | 11.99 | 9.57 | 3 | 215746 | 3 | 63273270 |
Chronic idiopathic pain syndrome | 11.99 | 9.57 | 3 | 215746 | 3 | 63273270 |
Nail disorder | 11.96 | 9.57 | 16 | 215733 | 12999 | 63260274 |
Muscle tension dysphonia | 11.91 | 9.57 | 8 | 215741 | 206 | 63273067 |
Red blood cell count decreased | 11.86 | 9.57 | 85 | 215664 | 40560 | 63232713 |
Pleural effusion | 11.81 | 9.57 | 407 | 215342 | 92803 | 63180470 |
Sickle cell anaemia with crisis | 11.81 | 9.57 | 46 | 215703 | 5957 | 63267316 |
Intestinal strangulation | 11.80 | 9.57 | 6 | 215743 | 90 | 63273183 |
Splenic injury | 11.71 | 9.57 | 8 | 215741 | 212 | 63273061 |
Product selection error | 11.68 | 9.57 | 6 | 215743 | 92 | 63273181 |
Impaired quality of life | 11.63 | 9.57 | 18 | 215731 | 13765 | 63259508 |
Accidental underdose | 11.62 | 9.57 | 14 | 215735 | 789 | 63272484 |
Denture wearer | 11.58 | 9.57 | 8 | 215741 | 216 | 63273057 |
Pathological fracture | 11.57 | 9.57 | 60 | 215689 | 8774 | 63264499 |
COVID-19 pneumonia | 11.57 | 9.57 | 19 | 215730 | 14190 | 63259083 |
Neoplasm progression | 11.56 | 9.57 | 181 | 215568 | 36247 | 63237026 |
Hip surgery | 11.55 | 9.57 | 31 | 215718 | 3300 | 63269973 |
Amenorrhoea | 11.55 | 9.57 | 10 | 215739 | 9904 | 63263369 |
Brain injury | 11.52 | 9.57 | 51 | 215698 | 6992 | 63266281 |
Cardiac death | 11.49 | 9.57 | 12 | 215737 | 577 | 63272696 |
Haematotoxicity | 11.49 | 9.57 | 9 | 215740 | 9367 | 63263906 |
Asthenia | 11.47 | 9.57 | 1135 | 214614 | 382469 | 62890804 |
Influenza like illness | 11.42 | 9.57 | 159 | 215590 | 66665 | 63206608 |
Pharyngitis | 11.38 | 9.57 | 33 | 215716 | 20110 | 63253163 |
Incision site swelling | 11.36 | 9.57 | 8 | 215741 | 223 | 63273050 |
Acute kidney injury | 11.34 | 9.57 | 1041 | 214708 | 262374 | 63010899 |
Monoplegia | 11.31 | 9.57 | 30 | 215719 | 3171 | 63270102 |
Adiposis dolorosa | 11.28 | 9.57 | 9 | 215740 | 304 | 63272969 |
Sleep disorder | 11.28 | 9.57 | 202 | 215547 | 81364 | 63191909 |
Ischaemic stroke | 11.21 | 9.57 | 28 | 215721 | 17929 | 63255344 |
Intestinal obstruction | 11.16 | 9.57 | 157 | 215592 | 30742 | 63242531 |
Nephrostomy | 11.13 | 9.57 | 6 | 215743 | 102 | 63273171 |
Injection site induration | 11.12 | 9.57 | 9 | 215740 | 9217 | 63264056 |
Respiratory rate increased | 11.11 | 9.57 | 82 | 215667 | 13566 | 63259707 |
Product dose omission in error | 11.10 | 9.57 | 6 | 215743 | 7606 | 63265667 |
Colorectal cancer metastatic | 11.10 | 9.57 | 12 | 215737 | 601 | 63272672 |
Postoperative ileus | 11.06 | 9.57 | 11 | 215738 | 499 | 63272774 |
Anaesthetic complication pulmonary | 11.05 | 9.57 | 5 | 215744 | 57 | 63273216 |
Lupus vulgaris | 11.04 | 9.57 | 45 | 215704 | 5949 | 63267324 |
Surgery | 11.02 | 9.57 | 74 | 215675 | 35838 | 63237435 |
Heat stroke | 11.01 | 9.57 | 14 | 215735 | 834 | 63272439 |
Menstruation irregular | 11 | 9.57 | 5 | 215744 | 6999 | 63266274 |
Pharyngitis streptococcal | 11.00 | 9.57 | 12 | 215737 | 10660 | 63262613 |
Gastritis fungal | 10.93 | 9.57 | 6 | 215743 | 106 | 63273167 |
Laryngectomy | 10.91 | 9.57 | 4 | 215745 | 25 | 63273248 |
Hepatitis fulminant | 10.79 | 9.57 | 31 | 215718 | 3433 | 63269840 |
Buttock injury | 10.79 | 9.57 | 8 | 215741 | 242 | 63273031 |
Bone marrow failure | 10.76 | 9.57 | 57 | 215692 | 29233 | 63244040 |
Multiple drug therapy | 10.75 | 9.57 | 32 | 215717 | 3614 | 63269659 |
Dehydration | 10.75 | 9.57 | 705 | 215044 | 172649 | 63100624 |
Foetal arrhythmia | 10.71 | 9.57 | 7 | 215742 | 172 | 63273101 |
Granulocytopenia | 10.70 | 9.57 | 3 | 215746 | 5669 | 63267604 |
Device issue | 10.69 | 9.57 | 43 | 215706 | 23738 | 63249535 |
Metastases to oesophagus | 10.65 | 9.57 | 4 | 215745 | 27 | 63273246 |
Tinnitus | 10.65 | 9.57 | 74 | 215675 | 35554 | 63237719 |
Intraventricular haemorrhage neonatal | 10.64 | 9.57 | 7 | 215742 | 174 | 63273099 |
Neurodevelopmental disorder | 10.64 | 9.57 | 7 | 215742 | 174 | 63273099 |
Gastrointestinal haemorrhage | 10.61 | 9.57 | 203 | 215546 | 80973 | 63192300 |
Symptom masked | 10.61 | 9.57 | 13 | 215736 | 746 | 63272527 |
Paraesthesia oral | 10.57 | 9.57 | 106 | 215643 | 19150 | 63254123 |
Haemangioma of skin | 10.56 | 9.57 | 10 | 215739 | 427 | 63272846 |
Stridor | 10.54 | 9.57 | 31 | 215718 | 3479 | 63269794 |
Thrombocytopenia | 10.53 | 9.57 | 621 | 215128 | 150536 | 63122737 |
Administration site erythema | 10.52 | 9.57 | 13 | 215736 | 752 | 63272521 |
Blood glucose increased | 10.48 | 9.57 | 211 | 215538 | 83545 | 63189728 |
Thyroxine decreased | 10.47 | 9.57 | 12 | 215737 | 641 | 63272632 |
Cardiac murmur | 10.47 | 9.57 | 21 | 215728 | 14531 | 63258742 |
Vulvovaginal candidiasis | 10.46 | 9.57 | 29 | 215720 | 3146 | 63270127 |
Inappropriate schedule of product administration | 10.45 | 9.57 | 271 | 215478 | 103694 | 63169579 |
Delayed recovery from anaesthesia | 10.44 | 9.57 | 13 | 215736 | 758 | 63272515 |
Adverse event | 10.42 | 9.57 | 164 | 215585 | 67395 | 63205878 |
Vertigo | 10.41 | 9.57 | 142 | 215607 | 59745 | 63213528 |
Tooth hypoplasia | 10.40 | 9.57 | 5 | 215744 | 66 | 63273207 |
Hiatus hernia | 10.38 | 9.57 | 38 | 215711 | 21556 | 63251717 |
Carcinoid crisis | 10.35 | 9.57 | 8 | 215741 | 258 | 63273015 |
Abdominal hernia | 10.34 | 9.57 | 39 | 215710 | 4973 | 63268300 |
Spleen congestion | 10.31 | 9.57 | 6 | 215743 | 119 | 63273154 |
Infrequent bowel movements | 10.31 | 9.57 | 17 | 215732 | 1285 | 63271988 |
Eye swelling | 10.28 | 9.57 | 44 | 215705 | 23874 | 63249399 |
Urinary tract obstruction | 10.27 | 9.57 | 23 | 215726 | 2185 | 63271088 |
Squamous cell carcinoma of skin | 10.24 | 9.57 | 4 | 215745 | 6128 | 63267145 |
Renal cyst | 10.23 | 9.57 | 65 | 215684 | 10237 | 63263036 |
Therapeutic product effect prolonged | 10.21 | 9.57 | 9 | 215740 | 350 | 63272923 |
Pocket erosion | 10.19 | 9.57 | 3 | 215746 | 8 | 63273265 |
Urticaria aquagenic | 10.18 | 9.57 | 4 | 215745 | 31 | 63273242 |
Hypertension | 10.15 | 9.57 | 814 | 214935 | 278489 | 62994784 |
Brain death | 10.13 | 9.57 | 30 | 215719 | 3380 | 63269893 |
Non-small cell lung cancer | 10.08 | 9.57 | 31 | 215718 | 3564 | 63269709 |
Upper respiratory tract infection | 10.08 | 9.57 | 357 | 215392 | 81690 | 63191583 |
Urticaria cholinergic | 10.07 | 9.57 | 4 | 215745 | 32 | 63273241 |
Mastoiditis | 10.05 | 9.57 | 15 | 215734 | 1040 | 63272233 |
Neutropenia | 10.03 | 9.57 | 489 | 215260 | 174516 | 63098757 |
Hypercreatininaemia | 10.03 | 9.57 | 11 | 215738 | 560 | 63272713 |
Urinary tract infection | 9.99 | 9.57 | 769 | 214980 | 263915 | 63009358 |
Cytomegalovirus infection | 9.98 | 9.57 | 37 | 215712 | 20915 | 63252358 |
Nasal polyps | 9.98 | 9.57 | 4 | 215745 | 6035 | 63267238 |
C-reactive protein increased | 9.94 | 9.57 | 405 | 215344 | 94302 | 63178971 |
Thirst decreased | 9.89 | 9.57 | 8 | 215741 | 276 | 63272997 |
Erysipelas | 9.88 | 9.57 | 53 | 215696 | 7852 | 63265421 |
Joint range of motion decreased | 9.86 | 9.57 | 67 | 215682 | 32361 | 63240912 |
Atypical femur fracture | 9.84 | 9.57 | 3 | 215746 | 5369 | 63267904 |
Sepsis neonatal | 9.83 | 9.57 | 10 | 215739 | 466 | 63272807 |
Haemophagocytic lymphohistiocytosis | 9.83 | 9.57 | 13 | 215736 | 10614 | 63262659 |
Vascular device infection | 9.81 | 9.57 | 50 | 215699 | 7262 | 63266011 |
Intestinal perforation | 9.81 | 9.57 | 72 | 215677 | 11891 | 63261382 |
Blood creatine phosphokinase MB increased | 9.79 | 9.57 | 16 | 215733 | 1200 | 63272073 |
Cardiomyopathy | 9.79 | 9.57 | 29 | 215720 | 17555 | 63255718 |
Ocular hyperaemia | 9.77 | 9.57 | 48 | 215701 | 25096 | 63248177 |
Paraesthesia | 9.72 | 9.57 | 435 | 215314 | 156531 | 63116742 |
PO2 abnormal | 9.70 | 9.57 | 3 | 215746 | 10 | 63273263 |
Herpes zoster | 9.68 | 9.57 | 357 | 215392 | 82105 | 63191168 |
Enthesopathy | 9.66 | 9.57 | 9 | 215740 | 8605 | 63264668 |
Renal disorder | 9.60 | 9.57 | 69 | 215680 | 32905 | 63240368 |
Intentional dose omission | 9.58 | 9.57 | 8 | 215741 | 8067 | 63265206 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Toxicity to various agents | 1660.28 | 10.46 | 2936 | 139093 | 197426 | 34617476 |
Drug abuse | 1365.86 | 10.46 | 1840 | 140189 | 97256 | 34717646 |
Drug hypersensitivity | 1207.57 | 10.46 | 1559 | 140470 | 78970 | 34735932 |
Respiratory depression | 708.56 | 10.46 | 562 | 141467 | 15683 | 34799219 |
Overdose | 644.56 | 10.46 | 1250 | 140779 | 89809 | 34725093 |
Drug dependence | 507.75 | 10.46 | 557 | 141472 | 23660 | 34791242 |
Accidental overdose | 406.23 | 10.46 | 454 | 141575 | 19686 | 34795216 |
Miosis | 359.21 | 10.46 | 303 | 141726 | 9232 | 34805670 |
Substance abuse | 292.33 | 10.46 | 245 | 141784 | 7396 | 34807506 |
Somnolence | 277.21 | 10.46 | 1036 | 140993 | 110080 | 34704822 |
Poisoning | 259.28 | 10.46 | 283 | 141746 | 11943 | 34802959 |
Death | 259.00 | 10.46 | 2608 | 139421 | 395441 | 34419461 |
Respiratory arrest | 248.76 | 10.46 | 425 | 141604 | 27618 | 34787284 |
Hyperaesthesia | 231.97 | 10.46 | 174 | 141855 | 4456 | 34810446 |
Depressed level of consciousness | 213.79 | 10.46 | 511 | 141518 | 42330 | 34772572 |
Drug withdrawal syndrome | 213.22 | 10.46 | 328 | 141701 | 19506 | 34795396 |
Off label use | 211.99 | 10.46 | 932 | 141097 | 418592 | 34396310 |
Sedation | 193.77 | 10.46 | 324 | 141705 | 20682 | 34794220 |
Asphyxia | 191.79 | 10.46 | 184 | 141845 | 6651 | 34808251 |
Unresponsive to stimuli | 189.17 | 10.46 | 374 | 141655 | 27195 | 34787707 |
Coma | 178.51 | 10.46 | 497 | 141532 | 45181 | 34769721 |
Delirium | 171.26 | 10.46 | 478 | 141551 | 43513 | 34771389 |
Confusional state | 160.70 | 10.46 | 1069 | 140960 | 143091 | 34671811 |
Bradypnoea | 147.72 | 10.46 | 109 | 141920 | 2720 | 34812182 |
Pulmonary oedema | 145.92 | 10.46 | 475 | 141554 | 47054 | 34767848 |
Mental status changes | 140.61 | 10.46 | 406 | 141623 | 37677 | 34777225 |
Accidental death | 138.18 | 10.46 | 99 | 141930 | 2357 | 34812545 |
Cardio-respiratory arrest | 133.17 | 10.46 | 510 | 141519 | 54763 | 34760139 |
Inadequate analgesia | 131.95 | 10.46 | 104 | 141925 | 2871 | 34812031 |
Intentional product misuse | 129.50 | 10.46 | 444 | 141585 | 45167 | 34769735 |
Drug screen positive | 123.80 | 10.46 | 113 | 141916 | 3830 | 34811072 |
Malignant neoplasm progression | 122.05 | 10.46 | 691 | 141338 | 87355 | 34727547 |
Acute chest syndrome | 119.21 | 10.46 | 61 | 141968 | 766 | 34814136 |
Constipation | 118.85 | 10.46 | 957 | 141072 | 136025 | 34678877 |
Completed suicide | 113.54 | 10.46 | 735 | 141294 | 97433 | 34717469 |
Cardiac arrest | 111.85 | 10.46 | 721 | 141308 | 95438 | 34719464 |
Lethargy | 111.27 | 10.46 | 394 | 141635 | 40728 | 34774174 |
Product dose omission issue | 101.97 | 10.46 | 208 | 141821 | 119503 | 34695399 |
Respiratory rate decreased | 101.48 | 10.46 | 81 | 141948 | 2278 | 34812624 |
Withdrawal syndrome | 99.07 | 10.46 | 180 | 141849 | 12275 | 34802627 |
Agitation | 94.19 | 10.46 | 472 | 141557 | 56927 | 34757975 |
Brain oedema | 90.59 | 10.46 | 184 | 141845 | 13637 | 34801265 |
Drug abuser | 88.15 | 10.46 | 94 | 141935 | 3860 | 34811042 |
Apnoea | 85.77 | 10.46 | 120 | 141909 | 6544 | 34808358 |
Drug ineffective | 85.06 | 10.46 | 1326 | 140703 | 455425 | 34359477 |
Vomiting | 81.67 | 10.46 | 1436 | 140593 | 246185 | 34568717 |
Sedation complication | 76.41 | 10.46 | 61 | 141968 | 1716 | 34813186 |
Myoclonus | 69.51 | 10.46 | 172 | 141857 | 14553 | 34800349 |
Product use in unapproved indication | 67.16 | 10.46 | 248 | 141781 | 117251 | 34697651 |
Myocardial infarction | 66.99 | 10.46 | 259 | 141770 | 120826 | 34694076 |
Nausea | 66.30 | 10.46 | 1828 | 140201 | 338080 | 34476822 |
Pulmonary congestion | 66.26 | 10.46 | 162 | 141867 | 13603 | 34801299 |
COVID-19 | 64.09 | 10.46 | 137 | 141892 | 77413 | 34737489 |
Cardiac failure congestive | 60.90 | 10.46 | 157 | 141872 | 83113 | 34731789 |
Drug use disorder | 60.82 | 10.46 | 80 | 141949 | 4111 | 34810791 |
Oxygen saturation decreased | 59.75 | 10.46 | 399 | 141630 | 53419 | 34761483 |
Hypoventilation | 58.82 | 10.46 | 71 | 141958 | 3343 | 34811559 |
Cytomegalovirus infection | 56.27 | 10.46 | 18 | 142011 | 26117 | 34788785 |
Pneumonia aspiration | 56.11 | 10.46 | 326 | 141703 | 41577 | 34773325 |
Myalgia | 55.99 | 10.46 | 166 | 141863 | 83944 | 34730958 |
Plasma cell myeloma | 54.97 | 10.46 | 325 | 141704 | 41712 | 34773190 |
Pain | 54.43 | 10.46 | 1149 | 140880 | 203526 | 34611376 |
Sphincter of Oddi dysfunction | 52.33 | 10.46 | 20 | 142009 | 116 | 34814786 |
Cough | 52.26 | 10.46 | 376 | 141653 | 149764 | 34665138 |
Hyperhidrosis | 51.65 | 10.46 | 502 | 141527 | 75190 | 34739712 |
Treatment failure | 50.99 | 10.46 | 69 | 141960 | 46628 | 34768274 |
Drug resistance | 48.91 | 10.46 | 22 | 142007 | 25905 | 34788997 |
Serotonin syndrome | 48.02 | 10.46 | 184 | 141845 | 19749 | 34795153 |
Sickle cell anaemia with crisis | 47.78 | 10.46 | 70 | 141959 | 3983 | 34810919 |
Hallucination | 46.31 | 10.46 | 363 | 141666 | 51135 | 34763767 |
Drug diversion | 46.19 | 10.46 | 34 | 141995 | 845 | 34814057 |
Hypoxia | 46.10 | 10.46 | 382 | 141647 | 54713 | 34760189 |
Exposure to toxic agent | 45.55 | 10.46 | 65 | 141964 | 3610 | 34811292 |
Respiratory acidosis | 45.36 | 10.46 | 77 | 141952 | 4973 | 34809929 |
Renal impairment | 44.40 | 10.46 | 215 | 141814 | 94298 | 34720604 |
Exposure via ingestion | 43.66 | 10.46 | 49 | 141980 | 2132 | 34812770 |
Hypoxic-ischaemic encephalopathy | 41.90 | 10.46 | 70 | 141959 | 4462 | 34810440 |
Cerebrovascular accident | 40.97 | 10.46 | 191 | 141838 | 84620 | 34730282 |
Condition aggravated | 40.44 | 10.46 | 544 | 141485 | 191652 | 34623250 |
Hospitalisation | 40.29 | 10.46 | 109 | 141920 | 56793 | 34758109 |
Melaena | 39.93 | 10.46 | 51 | 141978 | 35329 | 34779573 |
Respiratory distress | 39.92 | 10.46 | 265 | 141764 | 35400 | 34779502 |
Hypogonadism male | 39.68 | 10.46 | 22 | 142007 | 328 | 34814574 |
Syncope | 39.03 | 10.46 | 215 | 141814 | 91236 | 34723666 |
PCO2 increased | 38.94 | 10.46 | 27 | 142002 | 609 | 34814293 |
Coronary artery disease | 38.53 | 10.46 | 87 | 141942 | 48218 | 34766684 |
Dizziness | 37.59 | 10.46 | 643 | 141386 | 217878 | 34597024 |
Opiates positive | 36.36 | 10.46 | 25 | 142004 | 556 | 34814346 |
Tubulointerstitial nephritis | 34.97 | 10.46 | 21 | 142008 | 21003 | 34793899 |
Amnestic disorder | 34.69 | 10.46 | 18 | 142011 | 233 | 34814669 |
Cancer pain | 34.21 | 10.46 | 48 | 141981 | 2624 | 34812278 |
Haematochezia | 33.80 | 10.46 | 88 | 141941 | 46446 | 34768456 |
Diarrhoea | 33.36 | 10.46 | 1272 | 140757 | 388640 | 34426262 |
Clumsiness | 33.12 | 10.46 | 38 | 141991 | 1694 | 34813208 |
Accident | 32.84 | 10.46 | 67 | 141962 | 4980 | 34809922 |
Arthralgia | 32.68 | 10.46 | 490 | 141539 | 169551 | 34645351 |
Product used for unknown indication | 32.49 | 10.46 | 29 | 142000 | 954 | 34813948 |
Basal cell carcinoma | 32.19 | 10.46 | 20 | 142009 | 19638 | 34795264 |
Cardiac failure | 31.97 | 10.46 | 228 | 141801 | 91020 | 34723882 |
Blood glucose increased | 31.77 | 10.46 | 151 | 141878 | 66567 | 34748335 |
Atrial fibrillation | 31.65 | 10.46 | 331 | 141698 | 122062 | 34692840 |
Urinary retention | 31.64 | 10.46 | 254 | 141775 | 36034 | 34778868 |
Blood pH decreased | 31.49 | 10.46 | 43 | 141986 | 2291 | 34812611 |
Stupor | 31.32 | 10.46 | 48 | 141981 | 2843 | 34812059 |
Poisoning deliberate | 31.25 | 10.46 | 86 | 141943 | 7758 | 34807144 |
Diaphragmatic spasm | 30.60 | 10.46 | 13 | 142016 | 103 | 34814799 |
Aspiration | 30.56 | 10.46 | 114 | 141915 | 12080 | 34802822 |
Drug eruption | 30.22 | 10.46 | 22 | 142007 | 19876 | 34795026 |
Accidental poisoning | 29.53 | 10.46 | 25 | 142004 | 765 | 34814137 |
Diabetes mellitus inadequate control | 29.47 | 10.46 | 9 | 142020 | 13455 | 34801447 |
Self-medication | 29.45 | 10.46 | 45 | 141984 | 2658 | 34812244 |
Metastases to bone | 29.25 | 10.46 | 111 | 141918 | 11859 | 34803043 |
Faecal volume decreased | 29.17 | 10.46 | 13 | 142016 | 117 | 34814785 |
Dyspnoea | 28.40 | 10.46 | 1247 | 140782 | 375535 | 34439367 |
Haematuria | 28.36 | 10.46 | 106 | 141923 | 49960 | 34764942 |
Toxicologic test abnormal | 28.08 | 10.46 | 21 | 142008 | 535 | 34814367 |
Sinusitis | 28.05 | 10.46 | 81 | 141948 | 41321 | 34773581 |
Hypertension | 28.02 | 10.46 | 388 | 141641 | 136055 | 34678847 |
Postoperative ileus | 27.69 | 10.46 | 23 | 142006 | 685 | 34814217 |
Breakthrough pain | 27.32 | 10.46 | 21 | 142008 | 558 | 34814344 |
Visual acuity reduced | 27.04 | 10.46 | 16 | 142013 | 16133 | 34798769 |
Foetal exposure during pregnancy | 26.95 | 10.46 | 73 | 141956 | 38028 | 34776874 |
Allodynia | 26.45 | 10.46 | 24 | 142005 | 807 | 34814095 |
Hypotension | 26.30 | 10.46 | 1126 | 140903 | 220523 | 34594379 |
Pathogen resistance | 25.47 | 10.46 | 4 | 142025 | 9478 | 34805424 |
Full blood count abnormal | 25.41 | 10.46 | 23 | 142006 | 18645 | 34796257 |
Anaemia | 25.11 | 10.46 | 739 | 141290 | 232596 | 34582306 |
Injection site swelling | 24.70 | 10.46 | 8 | 142021 | 11519 | 34803383 |
Weight increased | 24.70 | 10.46 | 250 | 141779 | 92783 | 34722119 |
Neuroleptic malignant syndrome | 24.53 | 10.46 | 22 | 142007 | 17912 | 34796990 |
Hepatic function abnormal | 24.43 | 10.46 | 95 | 141934 | 44268 | 34770634 |
Interstitial lung disease | 24.41 | 10.46 | 160 | 141869 | 65122 | 34749780 |
Neoplasm progression | 24.21 | 10.46 | 170 | 141859 | 23130 | 34791772 |
Chronic kidney disease | 24.16 | 10.46 | 86 | 141943 | 41124 | 34773778 |
Glycosylated haemoglobin increased | 24.14 | 10.46 | 8 | 142021 | 11352 | 34803550 |
Herpes simplex viraemia | 24.00 | 10.46 | 10 | 142019 | 75 | 34814827 |
Spinal cord compression | 23.80 | 10.46 | 51 | 141978 | 3924 | 34810978 |
Drug-induced liver injury | 23.75 | 10.46 | 51 | 141978 | 28781 | 34786121 |
Fatigue | 23.71 | 10.46 | 1248 | 140781 | 369405 | 34445497 |
Hypercapnia | 23.67 | 10.46 | 53 | 141976 | 4202 | 34810700 |
Myelosuppression | 23.63 | 10.46 | 26 | 142003 | 19239 | 34795663 |
Gout | 23.60 | 10.46 | 26 | 142003 | 19227 | 34795675 |
Drug tolerance | 23.36 | 10.46 | 42 | 141987 | 2840 | 34812062 |
Failure to suspend medication | 23.15 | 10.46 | 17 | 142012 | 421 | 34814481 |
Therapeutic product effect incomplete | 23.13 | 10.46 | 116 | 141913 | 50425 | 34764477 |
Pulmonary haemorrhage | 23.10 | 10.46 | 93 | 141936 | 10211 | 34804691 |
Dyspnoea exertional | 22.99 | 10.46 | 94 | 141935 | 43185 | 34771717 |
Headache | 22.70 | 10.46 | 631 | 141398 | 200004 | 34614898 |
Disorientation | 22.56 | 10.46 | 220 | 141809 | 32968 | 34781934 |
Back pain | 22.21 | 10.46 | 650 | 141379 | 121139 | 34693763 |
Sinus tachycardia | 21.90 | 10.46 | 133 | 141896 | 17227 | 34797675 |
Lung cancer metastatic | 21.81 | 10.46 | 40 | 141989 | 2747 | 34812155 |
Transient ischaemic attack | 21.80 | 10.46 | 50 | 141979 | 27563 | 34787339 |
Intestinal obstruction | 21.69 | 10.46 | 163 | 141866 | 22659 | 34792243 |
Delusion of grandeur | 21.43 | 10.46 | 25 | 142004 | 1135 | 34813767 |
Diabetes mellitus | 21.21 | 10.46 | 108 | 141921 | 46765 | 34768137 |
Therapy interrupted | 20.99 | 10.46 | 15 | 142014 | 13682 | 34801220 |
Loss of personal independence in daily activities | 20.98 | 10.46 | 67 | 141962 | 33112 | 34781790 |
Nerve injury | 20.93 | 10.46 | 45 | 141984 | 3470 | 34811432 |
Reaction to excipient | 20.71 | 10.46 | 17 | 142012 | 498 | 34814404 |
Transplant rejection | 20.65 | 10.46 | 8 | 142021 | 10303 | 34804599 |
Progressive multifocal leukoencephalopathy | 20.53 | 10.46 | 7 | 142022 | 9757 | 34805145 |
Orthostatic hypotension | 20.40 | 10.46 | 47 | 141982 | 25872 | 34789030 |
Muscle swelling | 20.30 | 10.46 | 15 | 142014 | 375 | 34814527 |
Drug intolerance | 20.30 | 10.46 | 150 | 141879 | 59420 | 34755482 |
Angina unstable | 20.30 | 10.46 | 11 | 142018 | 11642 | 34803260 |
Rash | 20.25 | 10.46 | 721 | 141308 | 222031 | 34592871 |
Psoriasis | 20.18 | 10.46 | 85 | 141944 | 38727 | 34776175 |
Medication error | 20.18 | 10.46 | 175 | 141854 | 25390 | 34789512 |
Mydriasis | 20.13 | 10.46 | 70 | 141959 | 7167 | 34807735 |
Abdominal compartment syndrome | 20.09 | 10.46 | 22 | 142007 | 931 | 34813971 |
White blood cell count decreased | 20.09 | 10.46 | 270 | 141759 | 95175 | 34719727 |
Blood cholesterol increased | 19.85 | 10.46 | 33 | 141996 | 20510 | 34794392 |
Neurological examination abnormal | 19.81 | 10.46 | 13 | 142016 | 267 | 34814635 |
Non-small cell lung cancer | 19.63 | 10.46 | 47 | 141982 | 3893 | 34811009 |
Post procedural complication | 19.62 | 10.46 | 95 | 141934 | 11293 | 34803609 |
Body temperature increased | 19.40 | 10.46 | 129 | 141900 | 17239 | 34797663 |
Bladder dilatation | 19.40 | 10.46 | 27 | 142002 | 1465 | 34813437 |
Tumour pain | 19.20 | 10.46 | 23 | 142006 | 1074 | 34813828 |
Weaning failure | 19.05 | 10.46 | 12 | 142017 | 229 | 34814673 |
Neutropenia | 19.05 | 10.46 | 488 | 141541 | 156290 | 34658612 |
Secondary hypogonadism | 18.91 | 10.46 | 13 | 142016 | 289 | 34814613 |
Gastrointestinal motility disorder | 18.86 | 10.46 | 36 | 141993 | 2548 | 34812354 |
Hepatic enzyme increased | 18.86 | 10.46 | 88 | 141941 | 38992 | 34775910 |
Glomerular filtration rate decreased | 18.83 | 10.46 | 15 | 142014 | 12946 | 34801956 |
Drug level | 18.63 | 10.46 | 5 | 142024 | 6 | 34814896 |
Encephalopathy | 18.39 | 10.46 | 222 | 141807 | 35097 | 34779805 |
Rhinalgia | 18.30 | 10.46 | 22 | 142007 | 1031 | 34813871 |
Neuroblastoma | 18.27 | 10.46 | 11 | 142018 | 193 | 34814709 |
Pupil fixed | 18.25 | 10.46 | 29 | 142000 | 1772 | 34813130 |
Disease recurrence | 17.71 | 10.46 | 38 | 141991 | 21452 | 34793450 |
Patient uncooperative | 17.69 | 10.46 | 15 | 142014 | 460 | 34814442 |
Brain injury | 17.60 | 10.46 | 60 | 141969 | 6082 | 34808820 |
Acute myocardial infarction | 17.48 | 10.46 | 137 | 141892 | 53582 | 34761320 |
Tooth injury | 17.48 | 10.46 | 23 | 142006 | 1182 | 34813720 |
Bronchiectasis | 17.44 | 10.46 | 9 | 142020 | 9792 | 34805110 |
Peripheral swelling | 17.41 | 10.46 | 213 | 141816 | 76328 | 34738574 |
Myopathy | 17.26 | 10.46 | 13 | 142016 | 11541 | 34803361 |
C-reactive protein abnormal | 17.05 | 10.46 | 7 | 142022 | 8703 | 34806199 |
Apnoeic attack | 17.00 | 10.46 | 14 | 142015 | 412 | 34814490 |
Chemical poisoning | 16.98 | 10.46 | 9 | 142020 | 122 | 34814780 |
Cerebral infarction | 16.97 | 10.46 | 56 | 141973 | 27399 | 34787503 |
Incoherent | 16.94 | 10.46 | 48 | 141981 | 4404 | 34810498 |
Intensive care | 16.91 | 10.46 | 16 | 142013 | 568 | 34814334 |
Cyanosis | 16.88 | 10.46 | 99 | 141930 | 12665 | 34802237 |
Salivary hypersecretion | 16.83 | 10.46 | 7 | 142022 | 8637 | 34806265 |
Post stroke epilepsy | 16.78 | 10.46 | 5 | 142024 | 11 | 34814891 |
Visual impairment | 16.47 | 10.46 | 82 | 141947 | 35720 | 34779182 |
Substance use disorder | 16.45 | 10.46 | 18 | 142011 | 761 | 34814141 |
Post laminectomy syndrome | 16.44 | 10.46 | 10 | 142019 | 179 | 34814723 |
Polyneuropathy in malignant disease | 16.42 | 10.46 | 11 | 142018 | 234 | 34814668 |
Acute pulmonary oedema | 16.24 | 10.46 | 66 | 141963 | 7277 | 34807625 |
Pelvic pain | 16.23 | 10.46 | 33 | 141996 | 2447 | 34812455 |
C-reactive protein increased | 16.22 | 10.46 | 141 | 141888 | 53957 | 34760945 |
Biliary obstruction | 16.18 | 10.46 | 35 | 141994 | 2710 | 34812192 |
No adverse event | 16.16 | 10.46 | 44 | 141985 | 22883 | 34792019 |
Substance dependence | 16.15 | 10.46 | 13 | 142016 | 370 | 34814532 |
Cerebrospinal fluid leakage | 16.13 | 10.46 | 15 | 142014 | 521 | 34814381 |
Ischaemic stroke | 16.12 | 10.46 | 31 | 141998 | 18219 | 34796683 |
Psychotic behaviour | 16.06 | 10.46 | 17 | 142012 | 692 | 34814210 |
Carcinoid crisis | 16.02 | 10.46 | 11 | 142018 | 244 | 34814658 |
Device failure | 16.00 | 10.46 | 32 | 141997 | 2344 | 34812558 |
Visceral congestion | 15.88 | 10.46 | 16 | 142013 | 614 | 34814288 |
Vestibular disorder | 15.86 | 10.46 | 21 | 142008 | 1086 | 34813816 |
Thrombotic microangiopathy | 15.83 | 10.46 | 12 | 142017 | 10618 | 34804284 |
Lactic acidosis | 15.80 | 10.46 | 80 | 141949 | 34692 | 34780210 |
Aggression | 15.77 | 10.46 | 234 | 141795 | 38730 | 34776172 |
Respiratory failure | 15.77 | 10.46 | 564 | 141465 | 108008 | 34706894 |
Intentional product use issue | 15.76 | 10.46 | 161 | 141868 | 59655 | 34755247 |
Photosensitivity reaction | 15.72 | 10.46 | 12 | 142017 | 10582 | 34804320 |
Ejection fraction decreased | 15.68 | 10.46 | 34 | 141995 | 19120 | 34795782 |
Hypercholesterolaemia | 15.66 | 10.46 | 8 | 142021 | 8754 | 34806148 |
Immune reconstitution inflammatory syndrome | 15.65 | 10.46 | 8 | 142021 | 8751 | 34806151 |
SARS-CoV-2 test negative | 15.63 | 10.46 | 20 | 142009 | 1000 | 34813902 |
Drug reaction with eosinophilia and systemic symptoms | 15.54 | 10.46 | 75 | 141954 | 32937 | 34781965 |
Hypogammaglobulinaemia | 15.51 | 10.46 | 6 | 142023 | 7734 | 34807168 |
Angina pectoris | 15.51 | 10.46 | 70 | 141959 | 31293 | 34783609 |
Toxic leukoencephalopathy | 15.49 | 10.46 | 13 | 142016 | 393 | 34814509 |
Cluster headache | 15.43 | 10.46 | 15 | 142014 | 551 | 34814351 |
Squamous cell carcinoma of skin | 15.30 | 10.46 | 13 | 142016 | 10868 | 34804034 |
Accidental exposure to product by child | 15.28 | 10.46 | 24 | 142005 | 1452 | 34813450 |
Hypoglycaemia | 15.26 | 10.46 | 145 | 141884 | 54495 | 34760407 |
Dependence | 15.23 | 10.46 | 21 | 142008 | 1129 | 34813773 |
Decerebration | 15.21 | 10.46 | 5 | 142024 | 17 | 34814885 |
Eosinophilia | 15.18 | 10.46 | 55 | 141974 | 26167 | 34788735 |
Epstein-Barr virus infection | 15.14 | 10.46 | 6 | 142023 | 7622 | 34807280 |
Synovitis | 15.13 | 10.46 | 21 | 142008 | 14045 | 34800857 |
Hepatitis B | 15.03 | 10.46 | 3 | 142026 | 5980 | 34808922 |
Parathyroid hormone-related protein abnormal | 14.99 | 10.46 | 5 | 142024 | 18 | 34814884 |
Bladder cancer | 14.95 | 10.46 | 27 | 142002 | 16251 | 34798651 |
Infusion site granuloma | 14.82 | 10.46 | 4 | 142025 | 5 | 34814897 |
Pupillary reflex impaired | 14.77 | 10.46 | 24 | 142005 | 1495 | 34813407 |
Diabetic ketoacidosis | 14.76 | 10.46 | 32 | 141997 | 18000 | 34796902 |
Multiple sclerosis relapse | 14.74 | 10.46 | 19 | 142010 | 13114 | 34801788 |
Accidental underdose | 14.73 | 10.46 | 14 | 142015 | 500 | 34814402 |
Procedural vomiting | 14.68 | 10.46 | 10 | 142019 | 219 | 34814683 |
Anal inflammation | 14.67 | 10.46 | 22 | 142007 | 1278 | 34813624 |
Acute respiratory failure | 14.65 | 10.46 | 191 | 141838 | 30737 | 34784165 |
Bone marrow failure | 14.64 | 10.46 | 65 | 141964 | 29188 | 34785714 |
End stage renal disease | 14.53 | 10.46 | 9 | 142020 | 8852 | 34806050 |
Proteinuria | 14.52 | 10.46 | 34 | 141995 | 18608 | 34796294 |
Oesophageal carcinoma | 14.51 | 10.46 | 10 | 142019 | 9294 | 34805608 |
Fall | 14.50 | 10.46 | 675 | 141354 | 202210 | 34612692 |
Monocytopenia | 14.41 | 10.46 | 7 | 142022 | 78 | 34814824 |
Postmortem blood drug level abnormal | 14.39 | 10.46 | 11 | 142018 | 290 | 34814612 |
Blood triglycerides increased | 14.39 | 10.46 | 22 | 142007 | 14137 | 34800765 |
Liver disorder | 14.38 | 10.46 | 77 | 141952 | 32920 | 34781982 |
Carcinoid tumour | 14.33 | 10.46 | 10 | 142019 | 228 | 34814674 |
Victim of homicide | 14.27 | 10.46 | 8 | 142021 | 122 | 34814780 |
Thirst decreased | 14.21 | 10.46 | 5 | 142024 | 22 | 34814880 |
Hypertensive crisis | 14.19 | 10.46 | 9 | 142020 | 8742 | 34806160 |
Nephrotic syndrome | 14.08 | 10.46 | 6 | 142023 | 7297 | 34807605 |
Wrong technique in product usage process | 14.06 | 10.46 | 87 | 141942 | 35899 | 34779003 |
Eczema | 14.06 | 10.46 | 34 | 141995 | 18402 | 34796500 |
Scan gallium abnormal | 14.03 | 10.46 | 5 | 142024 | 23 | 34814879 |
Acidosis | 13.90 | 10.46 | 84 | 141945 | 10861 | 34804041 |
Haematotoxicity | 13.89 | 10.46 | 8 | 142021 | 8186 | 34806716 |
Disease prodromal stage | 13.86 | 10.46 | 5 | 142024 | 24 | 34814878 |
Liver function test | 13.76 | 10.46 | 6 | 142023 | 51 | 34814851 |
Vision blurred | 13.69 | 10.46 | 120 | 141909 | 45843 | 34769059 |
Medical device site bruise | 13.68 | 10.46 | 4 | 142025 | 8 | 34814894 |
Tuberculosis | 13.67 | 10.46 | 9 | 142020 | 8568 | 34806334 |
Product storage error | 13.67 | 10.46 | 8 | 142021 | 8114 | 34806788 |
Medical device site haemorrhage | 13.56 | 10.46 | 8 | 142021 | 135 | 34814767 |
Arrhythmia neonatal | 13.53 | 10.46 | 3 | 142026 | 0 | 34814902 |
Opiates | 13.53 | 10.46 | 3 | 142026 | 0 | 34814902 |
Small intestinal obstruction | 13.47 | 10.46 | 105 | 141924 | 14761 | 34800141 |
Head injury | 13.45 | 10.46 | 34 | 141995 | 18126 | 34796776 |
Anorgasmia | 13.44 | 10.46 | 17 | 142012 | 840 | 34814062 |
Prescribed underdose | 13.41 | 10.46 | 10 | 142019 | 8923 | 34805979 |
Ileus paralytic | 13.34 | 10.46 | 54 | 141975 | 5943 | 34808959 |
Hyponatraemia | 13.32 | 10.46 | 246 | 141783 | 82445 | 34732457 |
Pulmonary fibrosis | 13.19 | 10.46 | 35 | 141994 | 18361 | 34796541 |
Therapy cessation | 13.18 | 10.46 | 31 | 141998 | 16942 | 34797960 |
Lymphocyte count abnormal | 13.13 | 10.46 | 20 | 142009 | 1178 | 34813724 |
Electrocardiogram low voltage | 13.08 | 10.46 | 5 | 142024 | 29 | 34814873 |
Injection site pruritus | 13.05 | 10.46 | 6 | 142023 | 6977 | 34807925 |
Oesophagitis chemical | 13.00 | 10.46 | 6 | 142023 | 59 | 34814843 |
Megacolon | 12.95 | 10.46 | 25 | 142004 | 1785 | 34813117 |
Cardiac failure chronic | 12.92 | 10.46 | 8 | 142021 | 7871 | 34807031 |
Injection site pain | 12.91 | 10.46 | 99 | 141930 | 38906 | 34775996 |
Blood chromogranin A increased | 12.84 | 10.46 | 10 | 142019 | 271 | 34814631 |
Red blood cell sedimentation rate increased | 12.82 | 10.46 | 11 | 142018 | 9151 | 34805751 |
Cholestatic liver injury | 12.65 | 10.46 | 29 | 142000 | 2335 | 34812567 |
Nasopharyngitis | 12.61 | 10.46 | 204 | 141825 | 69764 | 34745138 |
Foetal exposure during delivery | 12.59 | 10.46 | 7 | 142022 | 105 | 34814797 |
Blood pH increased | 12.58 | 10.46 | 15 | 142014 | 697 | 34814205 |
Palpitations | 12.54 | 10.46 | 103 | 141926 | 39883 | 34775019 |
Erythema | 12.53 | 10.46 | 270 | 141759 | 88510 | 34726392 |
Impaired quality of life | 12.53 | 10.46 | 4 | 142025 | 5814 | 34809088 |
Subarachnoid haemorrhage | 12.49 | 10.46 | 20 | 142009 | 12615 | 34802287 |
Cheyne-Stokes respiration | 12.47 | 10.46 | 10 | 142019 | 283 | 34814619 |
Neutrophil count decreased | 12.47 | 10.46 | 140 | 141889 | 50964 | 34763938 |
Hypogonadism | 12.44 | 10.46 | 28 | 142001 | 2227 | 34812675 |
Foaming at mouth | 12.38 | 10.46 | 16 | 142013 | 808 | 34814094 |
Nephropathy toxic | 12.37 | 10.46 | 20 | 142009 | 12568 | 34802334 |
Proctalgia | 12.31 | 10.46 | 51 | 141978 | 5672 | 34809230 |
Arachnoiditis | 12.29 | 10.46 | 11 | 142018 | 363 | 34814539 |
Perineal pain | 12.24 | 10.46 | 16 | 142013 | 817 | 34814085 |
Eosinophilic myocarditis | 12.09 | 10.46 | 13 | 142016 | 539 | 34814363 |
Intentional misuse of drug delivery system | 12.08 | 10.46 | 4 | 142025 | 14 | 34814888 |
Respiratory paralysis | 12.04 | 10.46 | 6 | 142023 | 71 | 34814831 |
Vasculitis | 12.02 | 10.46 | 17 | 142012 | 11279 | 34803623 |
Syringe issue | 12.02 | 10.46 | 4 | 142025 | 5660 | 34809242 |
Bronchopulmonary aspergillosis | 12.01 | 10.46 | 26 | 142003 | 14633 | 34800269 |
Herpes zoster | 12.01 | 10.46 | 86 | 141943 | 34313 | 34780589 |
Hypersensitivity | 12.00 | 10.46 | 175 | 141854 | 60860 | 34754042 |
Asthma | 11.99 | 10.46 | 113 | 141916 | 42543 | 34772359 |
Anamnestic reaction | 11.95 | 10.46 | 5 | 142024 | 38 | 34814864 |
Gastrointestinal hypomotility | 11.88 | 10.46 | 18 | 142011 | 1055 | 34813847 |
Venoocclusive liver disease | 11.85 | 10.46 | 9 | 142020 | 7957 | 34806945 |
Product residue present | 11.84 | 10.46 | 31 | 141998 | 2715 | 34812187 |
Metastatic renal cell carcinoma | 11.83 | 10.46 | 26 | 142003 | 2035 | 34812867 |
Neuropathy peripheral | 11.82 | 10.46 | 253 | 141776 | 83010 | 34731892 |
Urinary tract infection | 11.78 | 10.46 | 256 | 141773 | 83825 | 34731077 |
Antasthmatic drug level | 11.73 | 10.46 | 5 | 142024 | 40 | 34814862 |
Cachexia | 11.71 | 10.46 | 59 | 141970 | 7127 | 34807775 |
Necrotising colitis | 11.70 | 10.46 | 18 | 142011 | 1070 | 34813832 |
Obsessive-compulsive disorder | 11.68 | 10.46 | 4 | 142025 | 5560 | 34809342 |
Disease progression | 11.67 | 10.46 | 544 | 141485 | 107533 | 34707369 |
Haemorrhagic stroke | 11.64 | 10.46 | 6 | 142023 | 6533 | 34808369 |
Appendicitis | 11.53 | 10.46 | 27 | 142002 | 14780 | 34800122 |
Muscle spasticity | 11.53 | 10.46 | 51 | 141978 | 5837 | 34809065 |
Metastases to lung | 11.50 | 10.46 | 71 | 141958 | 9249 | 34805653 |
Restlessness | 11.50 | 10.46 | 156 | 141873 | 25326 | 34789576 |
Disability | 11.49 | 10.46 | 44 | 141985 | 4721 | 34810181 |
Cardiac murmur | 11.47 | 10.46 | 9 | 142020 | 7828 | 34807074 |
Infantile fibromatosis | 11.46 | 10.46 | 3 | 142026 | 3 | 34814899 |
Atrial septal defect | 11.45 | 10.46 | 8 | 142021 | 7384 | 34807518 |
Analgesic drug level | 11.42 | 10.46 | 5 | 142024 | 43 | 34814859 |
Pemphigoid | 11.41 | 10.46 | 11 | 142018 | 8655 | 34806247 |
Device computer issue | 11.29 | 10.46 | 4 | 142025 | 18 | 34814884 |
Device toxicity | 11.29 | 10.46 | 4 | 142025 | 18 | 34814884 |
Chest discomfort | 11.20 | 10.46 | 155 | 141874 | 54375 | 34760527 |
Abdominal pain upper | 11.11 | 10.46 | 214 | 141815 | 71276 | 34743626 |
Alcohol poisoning | 11.09 | 10.46 | 36 | 141993 | 3557 | 34811345 |
Hypopnoea | 11.08 | 10.46 | 27 | 142002 | 2262 | 34812640 |
Blood pressure diastolic decreased | 11.05 | 10.46 | 69 | 141960 | 9025 | 34805877 |
Paraparesis | 11.04 | 10.46 | 24 | 142005 | 1865 | 34813037 |
Narcotic bowel syndrome | 11.00 | 10.46 | 7 | 142022 | 136 | 34814766 |
Atrioventricular block complete | 10.97 | 10.46 | 13 | 142016 | 9306 | 34805596 |
Extramedullary haemopoiesis | 10.91 | 10.46 | 6 | 142023 | 88 | 34814814 |
Respiration abnormal | 10.89 | 10.46 | 33 | 141996 | 3143 | 34811759 |
Product prescribing error | 10.84 | 10.46 | 52 | 141977 | 22875 | 34792027 |
Cor pulmonale acute | 10.81 | 10.46 | 9 | 142020 | 269 | 34814633 |
Conjunctival discolouration | 10.80 | 10.46 | 4 | 142025 | 21 | 34814881 |
Leukopenia | 10.76 | 10.46 | 185 | 141844 | 62671 | 34752231 |
Prostate cancer | 10.74 | 10.46 | 106 | 141923 | 39543 | 34775359 |
Electroencephalogram abnormal | 10.71 | 10.46 | 28 | 142001 | 2450 | 34812452 |
Eye irritation | 10.67 | 10.46 | 9 | 142020 | 7552 | 34807350 |
Haemophagocytic lymphohistiocytosis | 10.64 | 10.46 | 23 | 142006 | 12950 | 34801952 |
Large intestine perforation | 10.63 | 10.46 | 65 | 141964 | 8438 | 34806464 |
Lower respiratory tract infection viral | 10.62 | 10.46 | 10 | 142019 | 353 | 34814549 |
Rash pruritic | 10.59 | 10.46 | 65 | 141964 | 26876 | 34788026 |
Contraindicated product administered | 10.58 | 10.46 | 48 | 141981 | 21433 | 34793469 |
Ileus | 10.55 | 10.46 | 108 | 141921 | 16391 | 34798511 |
Sleep disorder due to a general medical condition | 10.54 | 10.46 | 4 | 142025 | 5217 | 34809685 |
Jaundice | 10.51 | 10.46 | 81 | 141948 | 31801 | 34783101 |
Alanine aminotransferase abnormal | 10.50 | 10.46 | 3 | 142026 | 4685 | 34810217 |
Kidney transplant rejection | 10.49 | 10.46 | 9 | 142020 | 7488 | 34807414 |
Vital functions abnormal | 10.48 | 10.46 | 9 | 142020 | 281 | 34814621 |
Large intestine polyp | 10.48 | 10.46 | 10 | 142019 | 7904 | 34806998 |
Acute graft versus host disease in skin | 10.48 | 10.46 | 4 | 142025 | 5197 | 34809705 |
Balance disorder | 10.47 | 10.46 | 110 | 141919 | 40544 | 34774358 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 5782.30 | 9.69 | 6342 | 294604 | 292574 | 79150868 |
Drug abuse | 2392.28 | 9.69 | 3006 | 297940 | 159685 | 79283757 |
Toxicity to various agents | 2339.67 | 9.69 | 5003 | 295943 | 416537 | 79026905 |
Respiratory depression | 1032.40 | 9.69 | 847 | 300099 | 26783 | 79416659 |
Overdose | 918.97 | 9.69 | 2099 | 298847 | 182107 | 79261335 |
Accidental overdose | 701.02 | 9.69 | 805 | 300141 | 38776 | 79404666 |
Sedation | 667.71 | 9.69 | 899 | 300047 | 50996 | 79392446 |
Death | 651.44 | 9.69 | 4003 | 296943 | 562511 | 78880931 |
Depressed level of consciousness | 649.49 | 9.69 | 1245 | 299701 | 95407 | 79348035 |
Miosis | 621.38 | 9.69 | 499 | 300447 | 15290 | 79428152 |
Respiratory arrest | 611.73 | 9.69 | 910 | 300036 | 56640 | 79386802 |
Constipation | 483.28 | 9.69 | 2232 | 298714 | 280818 | 79162624 |
Somnolence | 467.47 | 9.69 | 1963 | 298983 | 237018 | 79206424 |
Sedation complication | 437.45 | 9.69 | 407 | 300539 | 15262 | 79428180 |
Drug dependence | 429.39 | 9.69 | 642 | 300304 | 40127 | 79403315 |
Coma | 365.13 | 9.69 | 1017 | 299929 | 99632 | 79343810 |
Substance abuse | 360.63 | 9.69 | 307 | 300639 | 10219 | 79433223 |
Hyperaesthesia | 346.08 | 9.69 | 320 | 300626 | 11902 | 79431540 |
Poisoning | 343.73 | 9.69 | 450 | 300496 | 24822 | 79418620 |
Cardio-respiratory arrest | 338.54 | 9.69 | 1039 | 299907 | 107471 | 79335971 |
Bradypnoea | 335.72 | 9.69 | 235 | 300711 | 5817 | 79437625 |
Cardiac arrest | 331.90 | 9.69 | 1408 | 299538 | 170688 | 79272754 |
Completed suicide | 311.68 | 9.69 | 1784 | 299162 | 243983 | 79199459 |
Drug withdrawal syndrome | 306.25 | 9.69 | 504 | 300442 | 34214 | 79409228 |
Creatinine renal clearance decreased | 302.43 | 9.69 | 366 | 300580 | 18636 | 79424806 |
Unresponsive to stimuli | 301.55 | 9.69 | 657 | 300289 | 55131 | 79388311 |
Off label use | 254.13 | 9.69 | 2198 | 298748 | 905017 | 78538425 |
Asphyxia | 250.17 | 9.69 | 263 | 300683 | 11457 | 79431985 |
Respiratory rate decreased | 246.14 | 9.69 | 184 | 300762 | 5059 | 79438383 |
Blood calcium decreased | 237.48 | 9.69 | 429 | 300517 | 31390 | 79412052 |
Intentional product misuse | 218.13 | 9.69 | 822 | 300124 | 94343 | 79349099 |
Delirium | 207.41 | 9.69 | 747 | 300199 | 83880 | 79359562 |
Mental status changes | 202.13 | 9.69 | 634 | 300312 | 66325 | 79377117 |
Drug screen positive | 197.87 | 9.69 | 172 | 300774 | 5891 | 79437551 |
Vomiting | 191.67 | 9.69 | 3551 | 297395 | 662277 | 78781165 |
Acute chest syndrome | 186.25 | 9.69 | 99 | 300847 | 1462 | 79441980 |
Malignant neoplasm progression | 182.69 | 9.69 | 1003 | 299943 | 134987 | 79308455 |
Product dose omission issue | 178.06 | 9.69 | 421 | 300525 | 247116 | 79196326 |
Accidental death | 165.39 | 9.69 | 134 | 300812 | 4157 | 79439285 |
Confusional state | 162.95 | 9.69 | 1876 | 299070 | 316121 | 79127321 |
Myoclonus | 160.10 | 9.69 | 335 | 300611 | 27325 | 79416117 |
Drug abuser | 152.25 | 9.69 | 148 | 300798 | 5865 | 79437577 |
Pulmonary oedema | 151.73 | 9.69 | 698 | 300248 | 87556 | 79355886 |
COVID-19 | 144.74 | 9.69 | 232 | 300714 | 157442 | 79286000 |
Inadequate analgesia | 142.42 | 9.69 | 127 | 300819 | 4502 | 79438940 |
Hypotension | 142.34 | 9.69 | 2393 | 298553 | 437924 | 79005518 |
Lethargy | 139.05 | 9.69 | 642 | 300304 | 80650 | 79362792 |
Exposure via ingestion | 136.00 | 9.69 | 130 | 300816 | 5044 | 79438398 |
Alopecia | 133.97 | 9.69 | 437 | 300509 | 230918 | 79212524 |
Drug ineffective | 132.67 | 9.69 | 3090 | 297856 | 1077823 | 78365619 |
Systemic lupus erythematosus | 128.31 | 9.69 | 161 | 300785 | 120988 | 79322454 |
Apnoea | 127.06 | 9.69 | 187 | 300759 | 11517 | 79431925 |
Contrast media allergy | 126.24 | 9.69 | 92 | 300854 | 2430 | 79441012 |
Arthralgia | 125.95 | 9.69 | 1466 | 299480 | 570337 | 78873105 |
Maternal exposure during delivery | 121.35 | 9.69 | 71 | 300875 | 1275 | 79442167 |
Arthropathy | 121.21 | 9.69 | 309 | 300637 | 176802 | 79266640 |
Abdominal discomfort | 118.25 | 9.69 | 515 | 300431 | 250212 | 79193230 |
Cognitive disorder | 114.28 | 9.69 | 545 | 300401 | 69381 | 79374061 |
Orthostatic hypotension | 113.18 | 9.69 | 466 | 300480 | 55698 | 79387744 |
Weight increased | 110.44 | 9.69 | 605 | 300341 | 276781 | 79166661 |
Hypoxia | 110.09 | 9.69 | 717 | 300229 | 102526 | 79340916 |
Agitation | 109.71 | 9.69 | 698 | 300248 | 99017 | 79344425 |
Brain oedema | 109.60 | 9.69 | 273 | 300673 | 24990 | 79418452 |
Drug diversion | 105.01 | 9.69 | 63 | 300883 | 1187 | 79442255 |
Cardiac failure congestive | 103.28 | 9.69 | 241 | 300705 | 142161 | 79301281 |
Poisoning deliberate | 99.73 | 9.69 | 220 | 300726 | 18608 | 79424834 |
Hallucination | 97.93 | 9.69 | 606 | 300340 | 85139 | 79358303 |
Sinusitis | 95.58 | 9.69 | 396 | 300550 | 195105 | 79248337 |
Folliculitis | 94.94 | 9.69 | 45 | 300901 | 55335 | 79388107 |
Withdrawal syndrome | 94.01 | 9.69 | 268 | 300678 | 26586 | 79416856 |
Pemphigus | 92.81 | 9.69 | 145 | 300801 | 99437 | 79344005 |
Glossodynia | 91.14 | 9.69 | 156 | 300790 | 103181 | 79340261 |
Condition aggravated | 91.06 | 9.69 | 1337 | 299609 | 499787 | 78943655 |
Balance disorder | 90.86 | 9.69 | 662 | 300284 | 98195 | 79345247 |
Sleep disorder due to general medical condition, insomnia type | 86.85 | 9.69 | 28 | 300918 | 43528 | 79399914 |
Helicobacter infection | 86.70 | 9.69 | 81 | 300865 | 69623 | 79373819 |
Sphincter of Oddi dysfunction | 86.36 | 9.69 | 39 | 300907 | 394 | 79443048 |
Muscle injury | 85.51 | 9.69 | 38 | 300908 | 48523 | 79394919 |
Fatigue | 84.31 | 9.69 | 2772 | 298174 | 926955 | 78516487 |
Nausea | 84.30 | 9.69 | 4415 | 296531 | 952781 | 78490661 |
Device expulsion | 84.17 | 9.69 | 3 | 300943 | 25858 | 79417584 |
Respiratory acidosis | 82.28 | 9.69 | 150 | 300796 | 11050 | 79432392 |
Urinary retention | 81.64 | 9.69 | 426 | 300520 | 56204 | 79387238 |
Irritable bowel syndrome | 81.41 | 9.69 | 69 | 300877 | 62172 | 79381270 |
Oxygen saturation decreased | 78.36 | 9.69 | 788 | 300158 | 128259 | 79315183 |
Hand deformity | 76.85 | 9.69 | 174 | 300772 | 103745 | 79339697 |
Hypercapnia | 76.48 | 9.69 | 128 | 300818 | 8807 | 79434635 |
Myocardial infarction | 76.35 | 9.69 | 396 | 300550 | 183733 | 79259709 |
Swelling | 75.48 | 9.69 | 493 | 300453 | 216218 | 79227224 |
Aspiration | 74.32 | 9.69 | 205 | 300741 | 19953 | 79423489 |
Pericarditis | 74.30 | 9.69 | 178 | 300768 | 104058 | 79339384 |
Duodenal ulcer perforation | 73.26 | 9.69 | 85 | 300861 | 66126 | 79377316 |
Anterior spinal artery syndrome | 71.60 | 9.69 | 25 | 300921 | 117 | 79443325 |
Toxicologic test abnormal | 71.24 | 9.69 | 51 | 300895 | 1309 | 79442133 |
Peripheral swelling | 71.16 | 9.69 | 662 | 300284 | 268955 | 79174487 |
Cough | 69.94 | 9.69 | 969 | 299977 | 365820 | 79077622 |
Injection site erythema | 69.92 | 9.69 | 117 | 300829 | 78080 | 79365362 |
Hypoventilation | 69.33 | 9.69 | 109 | 300837 | 7115 | 79436327 |
Gastrointestinal disorder | 68.51 | 9.69 | 234 | 300712 | 121971 | 79321471 |
Acidosis | 67.99 | 9.69 | 196 | 300750 | 19566 | 79423876 |
Nasopharyngitis | 67.58 | 9.69 | 622 | 300324 | 253259 | 79190183 |
Pulmonary congestion | 67.02 | 9.69 | 240 | 300706 | 26860 | 79416582 |
Anti-cyclic citrullinated peptide antibody positive | 64.97 | 9.69 | 135 | 300811 | 83008 | 79360434 |
Myalgia | 64.29 | 9.69 | 423 | 300523 | 185218 | 79258224 |
Injection site swelling | 63.19 | 9.69 | 51 | 300895 | 47081 | 79396361 |
Dizziness | 63.07 | 9.69 | 1509 | 299437 | 524932 | 78918510 |
Plasma cell myeloma | 63.07 | 9.69 | 380 | 300566 | 52879 | 79390563 |
Cytomegalovirus infection | 62.54 | 9.69 | 42 | 300904 | 42602 | 79400840 |
Retinitis | 61.02 | 9.69 | 90 | 300856 | 5553 | 79437889 |
Injection site pruritus | 60.21 | 9.69 | 43 | 300903 | 42240 | 79401202 |
Intestinal pseudo-obstruction | 60.10 | 9.69 | 61 | 300885 | 2548 | 79440894 |
Syncope | 60.09 | 9.69 | 413 | 300533 | 179036 | 79264406 |
Mobility decreased | 59.87 | 9.69 | 715 | 300231 | 121460 | 79321982 |
Contusion | 58.87 | 9.69 | 325 | 300621 | 148451 | 79294991 |
Red blood cell sedimentation rate abnormal | 57.65 | 9.69 | 6 | 300940 | 20957 | 79422485 |
Respiratory failure | 57.10 | 9.69 | 980 | 299966 | 179931 | 79263511 |
Ill-defined disorder | 56.67 | 9.69 | 101 | 300845 | 65774 | 79377668 |
Opiates positive | 55.72 | 9.69 | 39 | 300907 | 965 | 79442477 |
Narcotic bowel syndrome | 55.15 | 9.69 | 25 | 300921 | 255 | 79443187 |
Visceral congestion | 55.08 | 9.69 | 38 | 300908 | 918 | 79442524 |
Dilatation intrahepatic duct acquired | 53.86 | 9.69 | 34 | 300912 | 704 | 79442738 |
Injection site reaction | 52.74 | 9.69 | 78 | 300868 | 54707 | 79388735 |
Impaired healing | 52.48 | 9.69 | 163 | 300783 | 87492 | 79355950 |
Diarrhoea | 52.47 | 9.69 | 2753 | 298193 | 877736 | 78565706 |
Serotonin syndrome | 51.88 | 9.69 | 319 | 300627 | 44708 | 79398734 |
Hyperhidrosis | 51.61 | 9.69 | 831 | 300115 | 150661 | 79292781 |
Hypoxic-ischaemic encephalopathy | 51.56 | 9.69 | 100 | 300846 | 7720 | 79435722 |
Full blood count abnormal | 51.56 | 9.69 | 46 | 300900 | 40428 | 79403014 |
Drug use disorder | 51.49 | 9.69 | 106 | 300840 | 8545 | 79434897 |
Intentional product use issue | 51.46 | 9.69 | 349 | 300597 | 151763 | 79291679 |
Drug resistance | 51.39 | 9.69 | 50 | 300896 | 42163 | 79401279 |
Hypersensitivity | 51.31 | 9.69 | 689 | 300257 | 261550 | 79181892 |
Joint swelling | 50.98 | 9.69 | 774 | 300172 | 287872 | 79155570 |
Hepatic enzyme increased | 50.94 | 9.69 | 442 | 300504 | 182168 | 79261274 |
Accidental exposure to product by child | 50.92 | 9.69 | 59 | 300887 | 2867 | 79440575 |
Coronary artery disease | 50.57 | 9.69 | 107 | 300839 | 65367 | 79378075 |
Abortion spontaneous | 50.54 | 9.69 | 24 | 300922 | 29483 | 79413959 |
Injection site pain | 50.08 | 9.69 | 286 | 300660 | 129552 | 79313890 |
Respiratory distress | 49.82 | 9.69 | 384 | 300562 | 57955 | 79385487 |
Post procedural complication | 49.81 | 9.69 | 200 | 300746 | 23629 | 79419813 |
Dyspnoea exertional | 49.29 | 9.69 | 166 | 300780 | 86907 | 79356535 |
Neutropenic sepsis | 48.69 | 9.69 | 217 | 300729 | 26847 | 79416595 |
Hypogonadism male | 47.49 | 9.69 | 20 | 300926 | 168 | 79443274 |
Hospitalisation | 47.20 | 9.69 | 189 | 300757 | 94047 | 79349395 |
Allodynia | 46.36 | 9.69 | 43 | 300903 | 1605 | 79441837 |
Dyspnoea | 46.36 | 9.69 | 2705 | 298241 | 854320 | 78589122 |
Sickle cell anaemia with crisis | 45.90 | 9.69 | 96 | 300850 | 7826 | 79435616 |
Blood pH decreased | 45.10 | 9.69 | 71 | 300875 | 4640 | 79438802 |
Spinal cord compression | 45.07 | 9.69 | 84 | 300862 | 6293 | 79437149 |
Tubulointerstitial nephritis | 44.59 | 9.69 | 47 | 300899 | 38188 | 79405254 |
Transient ischaemic attack | 44.24 | 9.69 | 82 | 300864 | 52613 | 79390829 |
Rash | 44.15 | 9.69 | 1760 | 299186 | 576598 | 78866844 |
Nasal congestion | 43.98 | 9.69 | 145 | 300801 | 76407 | 79367035 |
Cyanosis | 43.87 | 9.69 | 200 | 300746 | 24982 | 79418460 |
Progressive multifocal leukoencephalopathy | 43.33 | 9.69 | 12 | 300934 | 20588 | 79422854 |
Cerebrovascular accident | 43.25 | 9.69 | 376 | 300570 | 154916 | 79288526 |
Interstitial lung disease | 42.90 | 9.69 | 249 | 300697 | 112351 | 79331091 |
Wound | 42.64 | 9.69 | 260 | 300686 | 115919 | 79327523 |
Headache | 41.98 | 9.69 | 2028 | 298918 | 651744 | 78791698 |
Therapy interrupted | 41.90 | 9.69 | 34 | 300912 | 31307 | 79412135 |
C-reactive protein abnormal | 41.74 | 9.69 | 74 | 300872 | 48293 | 79395149 |
Pneumonia aspiration | 41.63 | 9.69 | 411 | 300535 | 66556 | 79376886 |
Transplant rejection | 41.49 | 9.69 | 11 | 300935 | 19426 | 79424016 |
Exostosis | 41.43 | 9.69 | 149 | 300797 | 16709 | 79426733 |
Pregnancy | 41.35 | 9.69 | 25 | 300921 | 26826 | 79416616 |
Blister | 40.96 | 9.69 | 273 | 300673 | 119203 | 79324239 |
Cardiac failure | 40.90 | 9.69 | 380 | 300566 | 154462 | 79288980 |
Contraindicated product administered | 40.59 | 9.69 | 389 | 300557 | 157149 | 79286293 |
Impaired work ability | 40.41 | 9.69 | 12 | 300934 | 19669 | 79423773 |
Eczema | 40.39 | 9.69 | 57 | 300889 | 40761 | 79402681 |
Pupillary reflex impaired | 39.95 | 9.69 | 56 | 300890 | 3297 | 79440145 |
Exposure to toxic agent | 39.75 | 9.69 | 99 | 300847 | 9059 | 79434383 |
Encephalopathy | 39.67 | 9.69 | 409 | 300537 | 66988 | 79376454 |
Cancer pain | 39.49 | 9.69 | 71 | 300875 | 5174 | 79438268 |
Joint dislocation | 39.35 | 9.69 | 147 | 300799 | 16792 | 79426650 |
Tenosynovitis | 39.02 | 9.69 | 6 | 300940 | 15548 | 79427894 |
Product use in unapproved indication | 38.38 | 9.69 | 689 | 300257 | 249670 | 79193772 |
Self-medication | 38.04 | 9.69 | 69 | 300877 | 5063 | 79438379 |
Synovitis | 37.24 | 9.69 | 376 | 300570 | 150358 | 79293084 |
Neutropenia | 37.11 | 9.69 | 815 | 300131 | 286895 | 79156547 |
Sopor | 36.92 | 9.69 | 42 | 300904 | 32968 | 79410474 |
Atrial fibrillation | 36.52 | 9.69 | 526 | 300420 | 197360 | 79246082 |
Postoperative ileus | 36.35 | 9.69 | 31 | 300915 | 1034 | 79442408 |
Multiple sclerosis relapse | 35.97 | 9.69 | 76 | 300870 | 46457 | 79396985 |
Obliterative bronchiolitis | 35.23 | 9.69 | 50 | 300896 | 2978 | 79440464 |
Wrong technique in product usage process | 35.23 | 9.69 | 151 | 300795 | 73724 | 79369718 |
Melaena | 35.21 | 9.69 | 115 | 300831 | 60775 | 79382667 |
Cholestasis | 34.96 | 9.69 | 325 | 300621 | 51784 | 79391658 |
Therapeutic product effect decreased | 34.82 | 9.69 | 423 | 300523 | 163440 | 79280002 |
Pupil fixed | 34.49 | 9.69 | 54 | 300892 | 3512 | 79439930 |
Small intestinal obstruction | 34.49 | 9.69 | 198 | 300748 | 27074 | 79416368 |
Hepatic function abnormal | 33.91 | 9.69 | 151 | 300795 | 72956 | 79370486 |
Musculoskeletal stiffness | 33.78 | 9.69 | 461 | 300485 | 174547 | 79268895 |
Soft tissue disorder | 33.68 | 9.69 | 53 | 300893 | 3462 | 79439980 |
Patient uncooperative | 33.39 | 9.69 | 25 | 300921 | 689 | 79442753 |
Lung cancer metastatic | 33.01 | 9.69 | 54 | 300892 | 3645 | 79439797 |
Intestinal obstruction | 32.83 | 9.69 | 276 | 300670 | 42744 | 79400698 |
Disorientation | 32.79 | 9.69 | 372 | 300574 | 62404 | 79381038 |
Incoherent | 32.19 | 9.69 | 82 | 300864 | 7610 | 79435832 |
Renal impairment | 32.14 | 9.69 | 411 | 300535 | 157372 | 79286070 |
Loss of personal independence in daily activities | 31.94 | 9.69 | 241 | 300705 | 102339 | 79341103 |
Myopathy | 31.87 | 9.69 | 19 | 300927 | 20544 | 79422898 |
PCO2 increased | 31.85 | 9.69 | 37 | 300909 | 1803 | 79441639 |
Aggression | 31.31 | 9.69 | 312 | 300634 | 50646 | 79392796 |
Skin candida | 31.27 | 9.69 | 39 | 300907 | 2048 | 79441394 |
Therapy cessation | 31.05 | 9.69 | 59 | 300887 | 37503 | 79405939 |
Impaired quality of life | 30.98 | 9.69 | 8 | 300938 | 14378 | 79429064 |
Diaphragmatic spasm | 30.79 | 9.69 | 13 | 300933 | 110 | 79443332 |
Procedural pain | 30.78 | 9.69 | 170 | 300776 | 22914 | 79420528 |
Chronic kidney disease | 30.46 | 9.69 | 137 | 300809 | 66017 | 79377425 |
Tendonitis | 30.45 | 9.69 | 27 | 300919 | 23803 | 79419639 |
Toxic leukoencephalopathy | 30.34 | 9.69 | 29 | 300917 | 1125 | 79442317 |
Neoplasm progression | 30.11 | 9.69 | 313 | 300633 | 51369 | 79392073 |
Product used for unknown indication | 30.05 | 9.69 | 33 | 300913 | 1511 | 79441931 |
Drug withdrawal syndrome neonatal | 30.03 | 9.69 | 17 | 300929 | 286 | 79443156 |
Mydriasis | 29.90 | 9.69 | 139 | 300807 | 17504 | 79425938 |
Sinus tachycardia | 29.89 | 9.69 | 240 | 300706 | 36668 | 79406774 |
Haematochezia | 29.67 | 9.69 | 201 | 300745 | 87444 | 79355998 |
Granulocytopenia | 29.63 | 9.69 | 4 | 300942 | 11427 | 79432015 |
Carcinoid tumour | 29.44 | 9.69 | 21 | 300925 | 536 | 79442906 |
Metastases to bone | 29.37 | 9.69 | 175 | 300771 | 24252 | 79419190 |
Disease recurrence | 29.35 | 9.69 | 78 | 300868 | 44031 | 79399411 |
Stomatitis | 29.26 | 9.69 | 384 | 300562 | 146373 | 79297069 |
Immune reconstitution inflammatory syndrome | 29.23 | 9.69 | 8 | 300938 | 13833 | 79429609 |
Ventilation perfusion mismatch | 29.02 | 9.69 | 22 | 300924 | 618 | 79442824 |
Weaning failure | 28.99 | 9.69 | 23 | 300923 | 692 | 79442750 |
Non-small cell lung cancer | 28.93 | 9.69 | 70 | 300876 | 6290 | 79437152 |
Drug tolerance | 28.84 | 9.69 | 85 | 300861 | 8590 | 79434852 |
Pancreatic fibrosis | 28.58 | 9.69 | 12 | 300934 | 100 | 79443342 |
Treatment failure | 28.44 | 9.69 | 462 | 300484 | 170024 | 79273418 |
Ischaemic stroke | 28.31 | 9.69 | 51 | 300895 | 33080 | 79410362 |
Hypertension | 28.14 | 9.69 | 994 | 299952 | 329998 | 79113444 |
Breakthrough pain | 28.12 | 9.69 | 30 | 300916 | 1329 | 79442113 |
Accident | 27.92 | 9.69 | 85 | 300861 | 8746 | 79434696 |
Eye pain | 27.71 | 9.69 | 63 | 300883 | 37515 | 79405927 |
Injection site rash | 27.26 | 9.69 | 17 | 300929 | 17937 | 79425505 |
Pathogen resistance | 27.24 | 9.69 | 10 | 300936 | 14332 | 79429110 |
Discomfort | 27.17 | 9.69 | 323 | 300623 | 125294 | 79318148 |
Myelosuppression | 27.00 | 9.69 | 71 | 300875 | 40225 | 79403217 |
Accidental poisoning | 26.50 | 9.69 | 32 | 300914 | 1625 | 79441817 |
Palpitations | 26.45 | 9.69 | 328 | 300618 | 126282 | 79317160 |
Stupor | 26.44 | 9.69 | 71 | 300875 | 6801 | 79436641 |
Tonsillar disorder | 26.29 | 9.69 | 28 | 300918 | 1238 | 79442204 |
Implant site extravasation | 26.25 | 9.69 | 23 | 300923 | 796 | 79442646 |
Bone erosion | 26.23 | 9.69 | 135 | 300811 | 17712 | 79425730 |
Gastrooesophageal reflux disease | 26.17 | 9.69 | 259 | 300687 | 103987 | 79339455 |
Vascular resistance systemic decreased | 26.09 | 9.69 | 14 | 300932 | 211 | 79443231 |
Carcinoid crisis | 26 | 9.69 | 19 | 300927 | 504 | 79442938 |
Diabetes mellitus | 25.93 | 9.69 | 181 | 300765 | 78209 | 79365233 |
Neuralgia | 25.91 | 9.69 | 215 | 300731 | 33169 | 79410273 |
Bone marrow failure | 25.91 | 9.69 | 102 | 300844 | 51005 | 79392437 |
Breast cancer female | 25.40 | 9.69 | 6 | 300940 | 11455 | 79431987 |
Faecal volume decreased | 25.00 | 9.69 | 13 | 300933 | 183 | 79443259 |
Urinary tract infection | 24.81 | 9.69 | 818 | 300128 | 273694 | 79169748 |
Anaphylactic reaction | 24.74 | 9.69 | 449 | 300497 | 83294 | 79360148 |
Blood glucose increased | 24.73 | 9.69 | 296 | 300650 | 114679 | 79328763 |
Neuroblastoma | 24.71 | 9.69 | 14 | 300932 | 236 | 79443206 |
Abdominal pain | 24.69 | 9.69 | 1747 | 299199 | 387822 | 79055620 |
Sepsis neonatal | 24.67 | 9.69 | 9 | 300937 | 49 | 79443393 |
Heavy menstrual bleeding | 24.61 | 9.69 | 11 | 300935 | 14000 | 79429442 |
Throat irritation | 24.60 | 9.69 | 76 | 300870 | 40870 | 79402572 |
Iron deficiency anaemia | 24.27 | 9.69 | 37 | 300909 | 25635 | 79417807 |
Back pain | 24.19 | 9.69 | 1391 | 299555 | 302789 | 79140653 |
Basal cell carcinoma | 24.18 | 9.69 | 67 | 300879 | 37308 | 79406134 |
Diffuse axonal injury | 24.11 | 9.69 | 11 | 300935 | 114 | 79443328 |
Gout | 24.05 | 9.69 | 35 | 300911 | 24714 | 79418728 |
Sternal fracture | 24.04 | 9.69 | 38 | 300908 | 2492 | 79440950 |
Myocardial fibrosis | 23.99 | 9.69 | 31 | 300915 | 1687 | 79441755 |
Sleep disorder due to a general medical condition | 23.86 | 9.69 | 12 | 300934 | 14265 | 79429177 |
Herpes simplex viraemia | 23.83 | 9.69 | 17 | 300929 | 434 | 79443008 |
Gangrene | 23.56 | 9.69 | 81 | 300865 | 8883 | 79434559 |
Hypoacusis | 23.51 | 9.69 | 49 | 300897 | 30101 | 79413341 |
Buttock injury | 23.46 | 9.69 | 12 | 300934 | 163 | 79443279 |
Coma scale abnormal | 23.32 | 9.69 | 79 | 300867 | 8599 | 79434843 |
Aplastic anaemia | 23.30 | 9.69 | 131 | 300815 | 17774 | 79425668 |
Cushingoid | 23.26 | 9.69 | 4 | 300942 | 9548 | 79433894 |
Glycosylated haemoglobin increased | 23.22 | 9.69 | 23 | 300923 | 19237 | 79424205 |
Liver disorder | 23.08 | 9.69 | 169 | 300777 | 72248 | 79371194 |
Product name confusion | 23.08 | 9.69 | 12 | 300934 | 169 | 79443273 |
Rhythm idioventricular | 23.03 | 9.69 | 19 | 300927 | 605 | 79442837 |
Colitis microscopic | 23.00 | 9.69 | 91 | 300855 | 10677 | 79432765 |
Hallucination, visual | 22.90 | 9.69 | 206 | 300740 | 32523 | 79410919 |
Dermatitis atopic | 22.82 | 9.69 | 5 | 300941 | 10051 | 79433391 |
Device difficult to use | 22.75 | 9.69 | 11 | 300935 | 13374 | 79430068 |
Blood alkaline phosphatase increased | 22.71 | 9.69 | 352 | 300594 | 63312 | 79380130 |
Infective pulmonary exacerbation of cystic fibrosis | 22.71 | 9.69 | 10 | 300936 | 12841 | 79430601 |
Administration site abscess | 22.71 | 9.69 | 7 | 300939 | 20 | 79443422 |
Pemphigoid | 22.57 | 9.69 | 15 | 300931 | 15300 | 79428142 |
Calcium deficiency | 22.52 | 9.69 | 22 | 300924 | 877 | 79442565 |
Tumour pain | 22.49 | 9.69 | 35 | 300911 | 2264 | 79441178 |
Gallbladder cholesterolosis | 22.45 | 9.69 | 19 | 300927 | 627 | 79442815 |
Infusion site granuloma | 22.45 | 9.69 | 6 | 300940 | 8 | 79443434 |
White blood cell count decreased | 22.39 | 9.69 | 540 | 300406 | 187748 | 79255694 |
Spinal cord injury | 22.35 | 9.69 | 26 | 300920 | 1269 | 79442173 |
Blood cholesterol increased | 22.29 | 9.69 | 205 | 300741 | 83515 | 79359927 |
Hyponatraemia | 22.28 | 9.69 | 506 | 300440 | 177342 | 79266100 |
Thrombotic microangiopathy | 22.19 | 9.69 | 26 | 300920 | 20143 | 79423299 |
Drug eruption | 22.07 | 9.69 | 88 | 300858 | 43847 | 79399595 |
Injection site bruising | 21.97 | 9.69 | 80 | 300866 | 40922 | 79402520 |
Vision blurred | 21.88 | 9.69 | 275 | 300671 | 105623 | 79337819 |
Occupational dermatitis | 21.86 | 9.69 | 11 | 300935 | 144 | 79443298 |
Haematotoxicity | 21.81 | 9.69 | 16 | 300930 | 15503 | 79427939 |
Apnoeic attack | 21.75 | 9.69 | 19 | 300927 | 655 | 79442787 |
Neurological examination abnormal | 21.66 | 9.69 | 18 | 300928 | 579 | 79442863 |
Drug level | 21.65 | 9.69 | 6 | 300940 | 10 | 79443432 |
Asthma | 21.57 | 9.69 | 369 | 300577 | 134726 | 79308716 |
Metastasis | 21.54 | 9.69 | 66 | 300880 | 6814 | 79436628 |
Pulseless electrical activity | 21.43 | 9.69 | 108 | 300838 | 14052 | 79429390 |
Alveolitis | 21.19 | 9.69 | 48 | 300898 | 4132 | 79439310 |
Neuroblastoma recurrent | 21.14 | 9.69 | 12 | 300934 | 203 | 79443239 |
Intentional self-injury | 21.06 | 9.69 | 58 | 300888 | 32361 | 79411081 |
Amnestic disorder | 20.97 | 9.69 | 18 | 300928 | 606 | 79442836 |
Hepatocellular injury | 20.93 | 9.69 | 273 | 300673 | 47320 | 79396122 |
Administration site discharge | 20.92 | 9.69 | 7 | 300939 | 28 | 79443414 |
PO2 decreased | 20.90 | 9.69 | 39 | 300907 | 2924 | 79440518 |
Body temperature increased | 20.89 | 9.69 | 258 | 300688 | 44162 | 79399280 |
Systemic mastocytosis | 20.85 | 9.69 | 14 | 300932 | 323 | 79443119 |
Failure to suspend medication | 20.85 | 9.69 | 16 | 300930 | 458 | 79442984 |
Drug tolerance increased | 20.64 | 9.69 | 18 | 300928 | 619 | 79442823 |
Anaesthetic complication | 20.63 | 9.69 | 38 | 300908 | 2821 | 79440621 |
Bladder cancer | 20.61 | 9.69 | 26 | 300920 | 19500 | 79423942 |
Enthesopathy | 20.57 | 9.69 | 9 | 300937 | 11599 | 79431843 |
Implant site discharge | 20.48 | 9.69 | 11 | 300935 | 166 | 79443276 |
Victim of homicide | 20.43 | 9.69 | 11 | 300935 | 167 | 79443275 |
Administration site induration | 20.36 | 9.69 | 7 | 300939 | 31 | 79443411 |
Squamous cell carcinoma of skin | 20.34 | 9.69 | 14 | 300932 | 14019 | 79429423 |
Psoriatic arthropathy | 20.33 | 9.69 | 192 | 300754 | 77807 | 79365635 |
Low density lipoprotein increased | 20.16 | 9.69 | 4 | 300942 | 8618 | 79434824 |
Cardiac murmur | 20.13 | 9.69 | 18 | 300928 | 15806 | 79427636 |
Joint effusion | 20.06 | 9.69 | 23 | 300923 | 17991 | 79425451 |
Nodule | 20.00 | 9.69 | 35 | 300911 | 22959 | 79420483 |
Clonus | 19.93 | 9.69 | 64 | 300882 | 6776 | 79436666 |
Myelodysplastic syndrome | 19.84 | 9.69 | 54 | 300892 | 30247 | 79413195 |
No adverse event | 19.64 | 9.69 | 73 | 300873 | 37119 | 79406323 |
Salivary hypersecretion | 19.56 | 9.69 | 15 | 300931 | 14209 | 79429233 |
Administration site odour | 19.51 | 9.69 | 7 | 300939 | 36 | 79443406 |
Haematuria | 19.45 | 9.69 | 166 | 300780 | 68670 | 79374772 |
Device programming error | 19.43 | 9.69 | 11 | 300935 | 185 | 79443257 |
Anaesthesia | 19.35 | 9.69 | 16 | 300930 | 511 | 79442931 |
Sepsis | 19.33 | 9.69 | 1221 | 299725 | 268207 | 79175235 |
Nephrotic syndrome | 19.27 | 9.69 | 9 | 300937 | 11165 | 79432277 |
Duodenal ulcer | 19.22 | 9.69 | 20 | 300926 | 16349 | 79427093 |
Haemophagocytic lymphohistiocytosis | 19.21 | 9.69 | 33 | 300913 | 21804 | 79421638 |
Wheezing | 19.17 | 9.69 | 317 | 300629 | 116347 | 79327095 |
Inflammation | 19.16 | 9.69 | 244 | 300702 | 93509 | 79349933 |
Disease progression | 19.14 | 9.69 | 865 | 300081 | 183497 | 79259945 |
Tachycardia | 19.10 | 9.69 | 837 | 300109 | 176931 | 79266511 |
Femur fracture | 19.05 | 9.69 | 78 | 300868 | 38574 | 79404868 |
Cerebral infarction | 19.04 | 9.69 | 98 | 300848 | 45578 | 79397864 |
Administration site haemorrhage | 19.02 | 9.69 | 8 | 300938 | 67 | 79443375 |
Agonal death struggle | 19.00 | 9.69 | 5 | 300941 | 6 | 79443436 |
Red blood cell count decreased | 18.92 | 9.69 | 133 | 300813 | 57380 | 79386062 |
Epstein-Barr virus infection | 18.83 | 9.69 | 16 | 300930 | 14400 | 79429042 |
Multiple-drug resistance | 18.77 | 9.69 | 5 | 300941 | 8803 | 79434639 |
Delusion of grandeur | 18.70 | 9.69 | 25 | 300921 | 1407 | 79442035 |
Pulmonary toxicity | 18.56 | 9.69 | 13 | 300933 | 12901 | 79430541 |
Chronic spontaneous urticaria | 18.54 | 9.69 | 23 | 300923 | 1201 | 79442241 |
Mucosal inflammation | 18.53 | 9.69 | 394 | 300552 | 75186 | 79368256 |
Splenic injury | 18.53 | 9.69 | 12 | 300934 | 260 | 79443182 |
Blood pH increased | 18.49 | 9.69 | 24 | 300922 | 1312 | 79442130 |
Joint range of motion decreased | 18.46 | 9.69 | 64 | 300882 | 33218 | 79410224 |
Pneumonia viral | 18.45 | 9.69 | 76 | 300870 | 9082 | 79434360 |
Type 2 diabetes mellitus | 18.35 | 9.69 | 133 | 300813 | 56989 | 79386453 |
Dry skin | 18.32 | 9.69 | 166 | 300780 | 67829 | 79375613 |
Erythema | 18.18 | 9.69 | 674 | 300272 | 222616 | 79220826 |
Blood chromogranin A increased | 17.93 | 9.69 | 15 | 300931 | 487 | 79442955 |
Hypothermia | 17.92 | 9.69 | 147 | 300799 | 22599 | 79420843 |
Lip dry | 17.92 | 9.69 | 19 | 300927 | 15399 | 79428043 |
Polyarthritis | 17.91 | 9.69 | 12 | 300934 | 12190 | 79431252 |
Mitral valve incompetence | 17.90 | 9.69 | 52 | 300894 | 28513 | 79414929 |
Substance dependence | 17.88 | 9.69 | 15 | 300931 | 489 | 79442953 |
Head discomfort | 17.86 | 9.69 | 17 | 300929 | 14485 | 79428957 |
Pathological fracture | 17.84 | 9.69 | 83 | 300863 | 10454 | 79432988 |
Increased bronchial secretion | 17.76 | 9.69 | 39 | 300907 | 3288 | 79440154 |
Iodine allergy | 17.76 | 9.69 | 16 | 300930 | 575 | 79442867 |
Aspergillus infection | 17.75 | 9.69 | 28 | 300918 | 19133 | 79424309 |
Antinuclear antibody positive | 17.75 | 9.69 | 4 | 300942 | 7886 | 79435556 |
Product quality issue | 17.68 | 9.69 | 67 | 300879 | 33873 | 79409569 |
Pulmonary tuberculosis | 17.67 | 9.69 | 4 | 300942 | 7861 | 79435581 |
Photosensitivity reaction | 17.62 | 9.69 | 33 | 300913 | 21094 | 79422348 |
Oesophageal carcinoma | 17.52 | 9.69 | 10 | 300936 | 11074 | 79432368 |
Maternal exposure during pregnancy | 17.51 | 9.69 | 387 | 300559 | 136151 | 79307291 |
Hepatic cirrhosis | 17.40 | 9.69 | 205 | 300741 | 34701 | 79408741 |
Breast cancer | 17.39 | 9.69 | 67 | 300879 | 33714 | 79409728 |
Neuroleptic malignant syndrome | 17.39 | 9.69 | 50 | 300896 | 27509 | 79415933 |
Hypogammaglobulinaemia | 17.37 | 9.69 | 14 | 300932 | 12937 | 79430505 |
Administration site erythema | 17.37 | 9.69 | 13 | 300933 | 358 | 79443084 |
Tuberculosis | 17.37 | 9.69 | 19 | 300927 | 15179 | 79428263 |
Squamous cell carcinoma | 17.34 | 9.69 | 20 | 300926 | 15602 | 79427840 |
Asthenia | 17.32 | 9.69 | 1679 | 299267 | 510010 | 78933432 |
Product monitoring error | 17.27 | 9.69 | 6 | 300940 | 8900 | 79434542 |
Dependence | 17.24 | 9.69 | 32 | 300914 | 2390 | 79441052 |
Neuroendocrine tumour of the lung | 17.20 | 9.69 | 6 | 300940 | 28 | 79443414 |
Renal disorder | 17.18 | 9.69 | 91 | 300855 | 42014 | 79401428 |
Alanine aminotransferase abnormal | 17.15 | 9.69 | 6 | 300940 | 8861 | 79434581 |
Foot deformity | 17.09 | 9.69 | 152 | 300794 | 23922 | 79419520 |
Feeling jittery | 17.08 | 9.69 | 14 | 300932 | 12827 | 79430615 |
Vaginal flatulence | 17.06 | 9.69 | 33 | 300913 | 2542 | 79440900 |
Proteinuria | 17.03 | 9.69 | 64 | 300882 | 32438 | 79411004 |
Onychomycosis | 17.03 | 9.69 | 5 | 300941 | 8256 | 79435186 |
Acute graft versus host disease in skin | 16.99 | 9.69 | 4 | 300942 | 7654 | 79435788 |
Postmortem blood drug level increased | 16.99 | 9.69 | 18 | 300928 | 791 | 79442651 |
Injection site cyst | 16.96 | 9.69 | 8 | 300938 | 90 | 79443352 |
Blood immunoglobulin A decreased | 16.92 | 9.69 | 24 | 300922 | 1429 | 79442013 |
Foetal monitoring abnormal | 16.88 | 9.69 | 10 | 300936 | 184 | 79443258 |
Depression | 16.85 | 9.69 | 658 | 300288 | 216132 | 79227310 |
Post stroke epilepsy | 16.84 | 9.69 | 5 | 300941 | 12 | 79443430 |
Rheumatic disorder | 16.84 | 9.69 | 37 | 300909 | 3121 | 79440321 |
Device failure | 16.83 | 9.69 | 57 | 300889 | 6204 | 79437238 |
Cerebrospinal fluid leakage | 16.81 | 9.69 | 26 | 300920 | 1673 | 79441769 |
Visual acuity reduced | 16.80 | 9.69 | 56 | 300890 | 29413 | 79414029 |
Nervous system disorder | 16.77 | 9.69 | 165 | 300781 | 26691 | 79416751 |
Wrong product administered | 16.77 | 9.69 | 73 | 300873 | 8939 | 79434503 |
Product storage error | 16.72 | 9.69 | 22 | 300924 | 16204 | 79427238 |
Reaction to excipient | 16.69 | 9.69 | 25 | 300921 | 1564 | 79441878 |
End stage renal disease | 16.66 | 9.69 | 13 | 300933 | 12207 | 79431235 |
Total lung capacity decreased | 16.59 | 9.69 | 35 | 300911 | 2870 | 79440572 |
Parkinsonism | 16.57 | 9.69 | 23 | 300923 | 16561 | 79426881 |
Medication error | 16.56 | 9.69 | 357 | 300589 | 68285 | 79375157 |
Personality disorder | 16.56 | 9.69 | 56 | 300890 | 6090 | 79437352 |
Gastrointestinal hypomotility | 16.53 | 9.69 | 28 | 300918 | 1945 | 79441497 |
Substance use | 16.53 | 9.69 | 19 | 300927 | 915 | 79442527 |
Chemical poisoning | 16.50 | 9.69 | 10 | 300936 | 192 | 79443250 |
Angina unstable | 16.43 | 9.69 | 23 | 300923 | 16504 | 79426938 |
Limb discomfort | 16.37 | 9.69 | 66 | 300880 | 32784 | 79410658 |
Eosinophilia | 16.36 | 9.69 | 102 | 300844 | 45243 | 79398199 |
Spinal epidural haemorrhage | 16.24 | 9.69 | 9 | 300937 | 145 | 79443297 |
Anaemia | 16.23 | 9.69 | 1452 | 299494 | 443563 | 78999879 |
Sensory loss | 16.22 | 9.69 | 94 | 300852 | 12897 | 79430545 |
Abdominal pain upper | 16.19 | 9.69 | 685 | 300261 | 223134 | 79220308 |
Infusion related reaction | 16.16 | 9.69 | 707 | 300239 | 229530 | 79213912 |
Suicide attempt | 16.16 | 9.69 | 218 | 300728 | 82714 | 79360728 |
Labelled drug-drug interaction medication error | 16.14 | 9.69 | 52 | 300894 | 27598 | 79415844 |
Exercise tolerance decreased | 16.12 | 9.69 | 7 | 300939 | 9064 | 79434378 |
Oropharyngeal pain | 16.09 | 9.69 | 303 | 300643 | 109050 | 79334392 |
Product prescribing error | 16.06 | 9.69 | 101 | 300845 | 44712 | 79398730 |
Immunosuppressant drug level increased | 15.99 | 9.69 | 7 | 300939 | 9020 | 79434422 |
Hyperlipidaemia | 15.99 | 9.69 | 48 | 300898 | 26045 | 79417397 |
Intensive care | 15.93 | 9.69 | 20 | 300926 | 1057 | 79442385 |
Nasal polyps | 15.92 | 9.69 | 4 | 300942 | 7323 | 79436119 |
Optic neuritis | 15.91 | 9.69 | 8 | 300938 | 9512 | 79433930 |
Gastrointestinal motility disorder | 15.81 | 9.69 | 55 | 300891 | 6067 | 79437375 |
Acute respiratory failure | 15.79 | 9.69 | 314 | 300632 | 59227 | 79384215 |
Pneumocystis jirovecii pneumonia | 15.77 | 9.69 | 66 | 300880 | 32442 | 79411000 |
Central nervous system injury | 15.76 | 9.69 | 9 | 300937 | 154 | 79443288 |
Biliary obstruction | 15.73 | 9.69 | 46 | 300900 | 4628 | 79438814 |
Fluid retention | 15.67 | 9.69 | 178 | 300768 | 69631 | 79373811 |
Pain | 15.63 | 9.69 | 2948 | 297998 | 700854 | 78742588 |
Surgery | 15.60 | 9.69 | 67 | 300879 | 32699 | 79410743 |
Blood phosphorus decreased | 15.60 | 9.69 | 58 | 300888 | 6610 | 79436832 |
Transplant dysfunction | 15.58 | 9.69 | 4 | 300942 | 7217 | 79436225 |
Lactic acidosis | 15.56 | 9.69 | 180 | 300766 | 70179 | 79373263 |
Acute myocardial infarction | 15.56 | 9.69 | 201 | 300745 | 76835 | 79366607 |
Polyneuropathy in malignant disease | 15.55 | 9.69 | 11 | 300935 | 277 | 79443165 |
Brain death | 15.54 | 9.69 | 52 | 300894 | 5625 | 79437817 |
Retrograde amnesia | 15.52 | 9.69 | 15 | 300931 | 590 | 79442852 |
Neuropathy peripheral | 15.52 | 9.69 | 410 | 300536 | 140895 | 79302547 |
Hepatitis B | 15.51 | 9.69 | 6 | 300940 | 8326 | 79435116 |
Paradoxical drug reaction | 15.46 | 9.69 | 4 | 300942 | 7181 | 79436261 |
Internal haemorrhage | 15.41 | 9.69 | 7 | 300939 | 8826 | 79434616 |
Parathyroid hormone-related protein abnormal | 15.36 | 9.69 | 5 | 300941 | 18 | 79443424 |
Leukoencephalopathy | 15.35 | 9.69 | 65 | 300881 | 7864 | 79435578 |
Respiratory tract infection | 15.34 | 9.69 | 114 | 300832 | 48575 | 79394867 |
Radiculopathy | 15.31 | 9.69 | 70 | 300876 | 8754 | 79434688 |
Urticaria thermal | 15.28 | 9.69 | 13 | 300933 | 432 | 79443010 |
Secondary hypogonadism | 15.24 | 9.69 | 12 | 300934 | 357 | 79443085 |
Basal ganglion degeneration | 15.21 | 9.69 | 13 | 300933 | 435 | 79443007 |
Rash pruritic | 15.17 | 9.69 | 185 | 300761 | 71444 | 79371998 |
Dysarthria | 15.15 | 9.69 | 348 | 300598 | 67274 | 79376168 |
Carotid artery occlusion | 15.10 | 9.69 | 5 | 300941 | 7642 | 79435800 |
Pain in extremity | 15.01 | 9.69 | 1178 | 299768 | 363360 | 79080082 |
Cardiopulmonary failure | 14.95 | 9.69 | 58 | 300888 | 6743 | 79436699 |
Acute graft versus host disease | 14.92 | 9.69 | 10 | 300936 | 10157 | 79433285 |
Skin cancer | 14.88 | 9.69 | 21 | 300925 | 15019 | 79428423 |
Cardiomyopathy | 14.86 | 9.69 | 57 | 300889 | 28717 | 79414725 |
Hypogonadism | 14.78 | 9.69 | 25 | 300921 | 1735 | 79441707 |
Breast cancer metastatic | 14.75 | 9.69 | 68 | 300878 | 8534 | 79434908 |
Thirst decreased | 14.73 | 9.69 | 11 | 300935 | 302 | 79443140 |
Drug-induced liver injury | 14.68 | 9.69 | 169 | 300777 | 65948 | 79377494 |
Seronegative arthritis | 14.68 | 9.69 | 45 | 300901 | 4647 | 79438795 |
Infection | 14.63 | 9.69 | 754 | 300192 | 240958 | 79202484 |
Respiratory rate increased | 14.63 | 9.69 | 135 | 300811 | 21465 | 79421977 |
Hostility | 14.58 | 9.69 | 29 | 300917 | 2281 | 79441161 |
PO2 abnormal | 14.57 | 9.69 | 5 | 300941 | 22 | 79443420 |
Demyelination | 14.57 | 9.69 | 6 | 300940 | 8017 | 79435425 |
Soft tissue injury | 14.56 | 9.69 | 25 | 300921 | 1756 | 79441686 |
Theft | 14.44 | 9.69 | 10 | 300936 | 243 | 79443199 |
Vascular malformation | 14.44 | 9.69 | 12 | 300934 | 386 | 79443056 |
Epidural analgesia | 14.39 | 9.69 | 6 | 300940 | 49 | 79443393 |
Product use issue | 14.38 | 9.69 | 646 | 300300 | 209176 | 79234266 |
Hypertensive crisis | 14.38 | 9.69 | 36 | 300910 | 20734 | 79422708 |
Cytopenia | 14.37 | 9.69 | 35 | 300911 | 20348 | 79423094 |
Medical device site infection | 14.35 | 9.69 | 14 | 300932 | 557 | 79442885 |
Lupus vulgaris | 14.34 | 9.69 | 36 | 300910 | 3310 | 79440132 |
Anal inflammation | 14.31 | 9.69 | 22 | 300924 | 1408 | 79442034 |
Uveitis | 14.29 | 9.69 | 26 | 300920 | 16804 | 79426638 |
Chest discomfort | 14.26 | 9.69 | 404 | 300542 | 137640 | 79305802 |
Incubator therapy | 14.19 | 9.69 | 6 | 300940 | 51 | 79443391 |
Vasculitis | 14.10 | 9.69 | 48 | 300898 | 25054 | 79418388 |
Acute pulmonary oedema | 14.06 | 9.69 | 97 | 300849 | 14133 | 79429309 |
Cardiac output decreased | 13.99 | 9.69 | 25 | 300921 | 1813 | 79441629 |
Restlessness | 13.98 | 9.69 | 250 | 300696 | 46242 | 79397200 |
Arachnoiditis | 13.98 | 9.69 | 16 | 300930 | 767 | 79442675 |
Eye pruritus | 13.97 | 9.69 | 36 | 300910 | 20534 | 79422908 |
Injection site induration | 13.96 | 9.69 | 10 | 300936 | 9809 | 79433633 |
Metastases to eye | 13.96 | 9.69 | 10 | 300936 | 257 | 79443185 |
Myoglobin urine | 13.89 | 9.69 | 5 | 300941 | 26 | 79443416 |
Intentional dose omission | 13.87 | 9.69 | 8 | 300938 | 8809 | 79434633 |
Hypopnoea | 13.87 | 9.69 | 48 | 300898 | 5281 | 79438161 |
Tissue infiltration | 13.85 | 9.69 | 15 | 300931 | 676 | 79442766 |
Kidney transplant rejection | 13.84 | 9.69 | 11 | 300935 | 10235 | 79433207 |
Infusion site pain | 13.82 | 9.69 | 20 | 300926 | 14156 | 79429286 |
Cardiac failure chronic | 13.77 | 9.69 | 13 | 300933 | 11122 | 79432320 |
Pulmonary haemorrhage | 13.77 | 9.69 | 99 | 300847 | 14618 | 79428824 |
Opiates | 13.75 | 9.69 | 3 | 300943 | 0 | 79443442 |
Femoral pulse abnormal | 13.75 | 9.69 | 3 | 300943 | 0 | 79443442 |
COVID-19 pneumonia | 13.73 | 9.69 | 59 | 300887 | 28790 | 79414652 |
Iron deficiency | 13.70 | 9.69 | 12 | 300934 | 10642 | 79432800 |
Bronchopulmonary aspergillosis | 13.67 | 9.69 | 41 | 300905 | 22253 | 79421189 |
Hallucination, tactile | 13.60 | 9.69 | 14 | 300932 | 595 | 79442847 |
Scan gallium abnormal | 13.59 | 9.69 | 5 | 300941 | 28 | 79443414 |
Bronchitis | 13.59 | 9.69 | 382 | 300564 | 130262 | 79313180 |
Cytomegalovirus infection reactivation | 13.58 | 9.69 | 8 | 300938 | 8708 | 79434734 |
Laboratory test abnormal | 13.57 | 9.69 | 57 | 300889 | 27991 | 79415451 |
Ileus | 13.54 | 9.69 | 155 | 300791 | 26056 | 79417386 |
Paraesthesia | 13.52 | 9.69 | 536 | 300410 | 175787 | 79267655 |
Brain injury | 13.52 | 9.69 | 82 | 300864 | 11435 | 79432007 |
Lymphocyte count abnormal | 13.49 | 9.69 | 22 | 300924 | 1481 | 79441961 |
Needle issue | 13.46 | 9.69 | 90 | 300856 | 12978 | 79430464 |
Proctitis | 13.45 | 9.69 | 54 | 300892 | 6378 | 79437064 |
Tooth injury | 13.45 | 9.69 | 26 | 300920 | 2002 | 79441440 |
Peripheral nerve injury | 13.45 | 9.69 | 15 | 300931 | 699 | 79442743 |
Lupus-like syndrome | 13.42 | 9.69 | 94 | 300852 | 13763 | 79429679 |
Blood triglycerides increased | 13.40 | 9.69 | 38 | 300908 | 21002 | 79422440 |
Deformity | 13.37 | 9.69 | 10 | 300936 | 9595 | 79433847 |
Cheyne-Stokes respiration | 13.35 | 9.69 | 13 | 300933 | 516 | 79442926 |
Megacolon | 13.34 | 9.69 | 36 | 300910 | 3459 | 79439983 |
Injection site discolouration | 13.34 | 9.69 | 6 | 300940 | 7608 | 79435834 |
Performance status decreased | 13.33 | 9.69 | 52 | 300894 | 6061 | 79437381 |
Large intestine polyp | 13.33 | 9.69 | 17 | 300929 | 12691 | 79430751 |
Foetal arrhythmia | 13.25 | 9.69 | 6 | 300940 | 61 | 79443381 |
Fear-related avoidance of activities | 13.25 | 9.69 | 7 | 300939 | 102 | 79443340 |
Malignant melanoma | 13.22 | 9.69 | 22 | 300924 | 14719 | 79428723 |
Substance use disorder | 13.22 | 9.69 | 17 | 300929 | 921 | 79442521 |
Joint injury | 13.19 | 9.69 | 67 | 300879 | 31268 | 79412174 |
Bacterial infection | 13.10 | 9.69 | 67 | 300879 | 31213 | 79412229 |
Stroke volume increased | 13.09 | 9.69 | 4 | 300942 | 11 | 79443431 |
Lymphopenia | 13.06 | 9.69 | 65 | 300881 | 30492 | 79412950 |
Paranasal cyst | 13.05 | 9.69 | 12 | 300934 | 443 | 79442999 |
Anamnestic reaction | 13.03 | 9.69 | 5 | 300941 | 32 | 79443410 |
Hypohidrosis | 13.01 | 9.69 | 10 | 300936 | 287 | 79443155 |
Thymus disorder | 13.01 | 9.69 | 10 | 300936 | 287 | 79443155 |
Cardiac pacemaker insertion | 13.00 | 9.69 | 3 | 300943 | 5819 | 79437623 |
Nephropathy toxic | 12.92 | 9.69 | 37 | 300909 | 20382 | 79423060 |
Laryngitis | 12.82 | 9.69 | 104 | 300842 | 15935 | 79427507 |
Dyslipidaemia | 12.79 | 9.69 | 15 | 300931 | 11618 | 79431824 |
Excessive eye blinking | 12.77 | 9.69 | 23 | 300923 | 1678 | 79441764 |
Consciousness fluctuating | 12.76 | 9.69 | 25 | 300921 | 1944 | 79441498 |
Bladder dilatation | 12.65 | 9.69 | 26 | 300920 | 2093 | 79441349 |
Electrocardiogram low voltage | 12.65 | 9.69 | 5 | 300941 | 35 | 79443407 |
Dose calculation error | 12.61 | 9.69 | 9 | 300937 | 230 | 79443212 |
Intentional misuse of drug delivery system | 12.60 | 9.69 | 4 | 300942 | 13 | 79443429 |
Cytomegalovirus viraemia | 12.59 | 9.69 | 18 | 300928 | 12803 | 79430639 |
Dehydration | 12.58 | 9.69 | 1094 | 299852 | 247093 | 79196349 |
Diabetes mellitus inadequate control | 12.57 | 9.69 | 48 | 300898 | 24216 | 79419226 |
Head injury | 12.50 | 9.69 | 86 | 300860 | 37283 | 79406159 |
Drug dose omission by device | 12.49 | 9.69 | 4 | 300942 | 6246 | 79437196 |
Libido increased | 12.48 | 9.69 | 25 | 300921 | 1976 | 79441466 |
Night sweats | 12.43 | 9.69 | 131 | 300815 | 51964 | 79391478 |
Skin disorder | 12.43 | 9.69 | 76 | 300870 | 33867 | 79409575 |
Paraparesis | 12.39 | 9.69 | 37 | 300909 | 3766 | 79439676 |
Glomerular filtration rate decreased | 12.36 | 9.69 | 44 | 300902 | 22658 | 79420784 |
Knee arthroplasty | 12.35 | 9.69 | 104 | 300842 | 43144 | 79400298 |
Product dose omission in error | 12.35 | 9.69 | 7 | 300939 | 7781 | 79435661 |
Lymphoproliferative disorder | 12.33 | 9.69 | 3 | 300943 | 5612 | 79437830 |
Pocket erosion | 12.30 | 9.69 | 5 | 300941 | 38 | 79443404 |
Rhinitis allergic | 12.27 | 9.69 | 17 | 300929 | 12252 | 79431190 |
Blood loss anaemia | 12.24 | 9.69 | 25 | 300921 | 15473 | 79427969 |
Appendicitis | 12.21 | 9.69 | 39 | 300907 | 20755 | 79422687 |
Skin fissures | 12.21 | 9.69 | 19 | 300927 | 13054 | 79430388 |
Psychotic behaviour | 12.20 | 9.69 | 18 | 300928 | 1111 | 79442331 |
Keratitis | 12.19 | 9.69 | 40 | 300906 | 4282 | 79439160 |
Metastases to spine | 12.18 | 9.69 | 40 | 300906 | 4284 | 79439158 |
Therapy partial responder | 12.16 | 9.69 | 30 | 300916 | 17367 | 79426075 |
Temperature regulation disorder | 12.13 | 9.69 | 49 | 300897 | 5804 | 79437638 |
Antasthmatic drug level | 12.08 | 9.69 | 5 | 300941 | 40 | 79443402 |
Amenorrhoea | 12.07 | 9.69 | 7 | 300939 | 7685 | 79435757 |
Hyperreflexia | 12.03 | 9.69 | 63 | 300883 | 8322 | 79435120 |
Gastrointestinal haemorrhage | 11.99 | 9.69 | 446 | 300500 | 147273 | 79296169 |
Jaundice | 11.99 | 9.69 | 136 | 300810 | 53213 | 79390229 |
Oesophagitis chemical | 11.96 | 9.69 | 6 | 300940 | 78 | 79443364 |
Flushing | 11.95 | 9.69 | 248 | 300698 | 88020 | 79355422 |
Breath sounds abnormal | 11.90 | 9.69 | 102 | 300844 | 15882 | 79427560 |
Pulse absent | 11.90 | 9.69 | 72 | 300874 | 10031 | 79433411 |
Coronary artery bypass | 11.90 | 9.69 | 4 | 300942 | 6058 | 79437384 |
Upper-airway cough syndrome | 11.90 | 9.69 | 16 | 300930 | 11677 | 79431765 |
Gastric dilatation | 11.89 | 9.69 | 20 | 300926 | 1382 | 79442060 |
Paraplegia | 11.86 | 9.69 | 44 | 300902 | 5009 | 79438433 |
Actinic keratosis | 11.84 | 9.69 | 4 | 300942 | 6038 | 79437404 |
Device use error | 11.82 | 9.69 | 6 | 300940 | 7095 | 79436347 |
Delayed recovery from anaesthesia | 11.78 | 9.69 | 22 | 300924 | 1651 | 79441791 |
Suicidal ideation | 11.71 | 9.69 | 210 | 300736 | 76130 | 79367312 |
Akathisia | 11.70 | 9.69 | 20 | 300926 | 13239 | 79430203 |
Respiratory paralysis | 11.70 | 9.69 | 6 | 300940 | 82 | 79443360 |
Subarachnoid haemorrhage | 11.67 | 9.69 | 50 | 300896 | 24415 | 79419027 |
Hypomania | 11.65 | 9.69 | 7 | 300939 | 7537 | 79435905 |
Hip arthroplasty | 11.61 | 9.69 | 83 | 300863 | 35673 | 79407769 |
Device toxicity | 11.58 | 9.69 | 4 | 300942 | 18 | 79443424 |
Female genital tract fistula | 11.58 | 9.69 | 49 | 300897 | 5926 | 79437516 |
Vertigo | 11.58 | 9.69 | 187 | 300759 | 68895 | 79374547 |
Analgesic drug level | 11.57 | 9.69 | 5 | 300941 | 45 | 79443397 |
Therapeutic response decreased | 11.53 | 9.69 | 180 | 300766 | 66673 | 79376769 |
Tongue disorder | 11.51 | 9.69 | 22 | 300924 | 13953 | 79429489 |
Adverse event | 11.47 | 9.69 | 159 | 300787 | 60055 | 79383387 |
Hypertransaminasaemia | 11.45 | 9.69 | 17 | 300929 | 11907 | 79431535 |
Muscle swelling | 11.42 | 9.69 | 15 | 300931 | 830 | 79442612 |
Haemorrhagic stroke | 11.36 | 9.69 | 15 | 300931 | 11031 | 79432411 |
Cardiac disorder | 11.36 | 9.69 | 177 | 300769 | 65580 | 79377862 |
Spinal cord paralysis | 11.35 | 9.69 | 7 | 300939 | 139 | 79443303 |
Perineal pain | 11.33 | 9.69 | 17 | 300929 | 1065 | 79442377 |
Fibrinolysis | 11.32 | 9.69 | 6 | 300940 | 88 | 79443354 |
Septic necrosis | 11.26 | 9.69 | 6 | 300940 | 89 | 79443353 |
Abdominal compartment syndrome | 11.24 | 9.69 | 21 | 300925 | 1576 | 79441866 |
Acute respiratory distress syndrome | 11.22 | 9.69 | 231 | 300715 | 43836 | 79399606 |
Pituitary apoplexy | 11.19 | 9.69 | 8 | 300938 | 205 | 79443237 |
Skin reaction | 11.17 | 9.69 | 101 | 300845 | 15967 | 79427475 |
Bronchopulmonary aspergillosis allergic | 11.15 | 9.69 | 31 | 300915 | 3030 | 79440412 |
Erythema multiforme | 11.15 | 9.69 | 32 | 300914 | 17619 | 79425823 |
Injection site extravasation | 11.15 | 9.69 | 12 | 300934 | 9657 | 79433785 |
Pain in jaw | 11.03 | 9.69 | 116 | 300830 | 46035 | 79397407 |
Increased tendency to bruise | 10.97 | 9.69 | 14 | 300932 | 10450 | 79432992 |
Cutaneous vasculitis | 10.97 | 9.69 | 9 | 300937 | 8243 | 79435199 |
Cluster headache | 10.94 | 9.69 | 16 | 300930 | 980 | 79442462 |
Peripheral ischaemia | 10.89 | 9.69 | 67 | 300879 | 9390 | 79434052 |
SARS-CoV-2 test negative | 10.89 | 9.69 | 19 | 300927 | 1352 | 79442090 |
Red cell distribution width increased | 10.88 | 9.69 | 26 | 300920 | 15216 | 79428226 |
Retinal haemorrhage | 10.88 | 9.69 | 9 | 300937 | 8208 | 79435234 |
Large intestine perforation | 10.87 | 9.69 | 93 | 300853 | 14474 | 79428968 |
Stridor | 10.79 | 9.69 | 45 | 300901 | 5408 | 79438034 |
Anorgasmia | 10.78 | 9.69 | 18 | 300928 | 1236 | 79442206 |
Epidural haemorrhage | 10.76 | 9.69 | 8 | 300938 | 218 | 79443224 |
Nocardiosis | 10.72 | 9.69 | 4 | 300942 | 5675 | 79437767 |
Intercepted product dispensing error | 10.72 | 9.69 | 7 | 300939 | 154 | 79443288 |
Rhinalgia | 10.71 | 9.69 | 26 | 300920 | 2341 | 79441101 |
Tension headache | 10.71 | 9.69 | 7 | 300939 | 7204 | 79436238 |
Obesity | 10.70 | 9.69 | 83 | 300863 | 35042 | 79408400 |
Dermo-hypodermitis | 10.66 | 9.69 | 14 | 300932 | 774 | 79442668 |
Mastoid disorder | 10.64 | 9.69 | 4 | 300942 | 24 | 79443418 |
Catheter site phlebitis | 10.64 | 9.69 | 4 | 300942 | 24 | 79443418 |
Monocytopenia | 10.60 | 9.69 | 7 | 300939 | 157 | 79443285 |
Dysphagia | 10.57 | 9.69 | 563 | 300383 | 121573 | 79321869 |
Post-traumatic neck syndrome | 10.56 | 9.69 | 24 | 300922 | 2070 | 79441372 |
Urine alcohol test positive | 10.50 | 9.69 | 4 | 300942 | 25 | 79443417 |
Analgesic drug level above therapeutic | 10.48 | 9.69 | 11 | 300935 | 478 | 79442964 |
Foetal megacystis | 10.48 | 9.69 | 3 | 300943 | 6 | 79443436 |
Intrapericardial thrombosis | 10.47 | 9.69 | 5 | 300941 | 58 | 79443384 |
Catheter site granuloma | 10.47 | 9.69 | 5 | 300941 | 58 | 79443384 |
Optic nerve operation | 10.46 | 9.69 | 11 | 300935 | 479 | 79442963 |
Adiposis dolorosa | 10.46 | 9.69 | 9 | 300937 | 304 | 79443138 |
Phlebitis | 10.45 | 9.69 | 63 | 300883 | 8767 | 79434675 |
Tongue oedema | 10.45 | 9.69 | 7 | 300939 | 7110 | 79436332 |
Graft versus host disease | 10.43 | 9.69 | 26 | 300920 | 15000 | 79428442 |
Gait disturbance | 10.42 | 9.69 | 659 | 300287 | 206847 | 79236595 |
Abortion induced | 10.42 | 9.69 | 7 | 300939 | 7102 | 79436340 |
Nephrosclerosis | 10.40 | 9.69 | 22 | 300924 | 1808 | 79441634 |
Proctalgia | 10.37 | 9.69 | 69 | 300877 | 9932 | 79433510 |
Abdominal wall mass | 10.37 | 9.69 | 4 | 300942 | 26 | 79443416 |
Rheumatoid factor positive | 10.36 | 9.69 | 161 | 300785 | 59678 | 79383764 |
Device computer issue | 10.34 | 9.69 | 6 | 300940 | 106 | 79443336 |
Abnormal behaviour | 10.31 | 9.69 | 194 | 300752 | 36227 | 79407215 |
Device issue | 10.29 | 9.69 | 60 | 300886 | 27048 | 79416394 |
Eye haemorrhage | 10.29 | 9.69 | 13 | 300933 | 9744 | 79433698 |
Laryngectomy | 10.25 | 9.69 | 4 | 300942 | 27 | 79443415 |
Vitamin D decreased | 10.21 | 9.69 | 13 | 300933 | 9712 | 79433730 |
Coronavirus infection | 10.19 | 9.69 | 8 | 300938 | 7489 | 79435953 |
Neurotoxicity | 10.19 | 9.69 | 176 | 300770 | 32342 | 79411100 |
Muscular weakness | 10.18 | 9.69 | 499 | 300447 | 160230 | 79283212 |
Mediastinal shift | 10.18 | 9.69 | 5 | 300941 | 62 | 79443380 |
Anaemia of malignant disease | 10.16 | 9.69 | 14 | 300932 | 811 | 79442631 |
Inappropriate antidiuretic hormone secretion | 10.12 | 9.69 | 58 | 300888 | 26255 | 79417187 |
Infusion site extravasation | 10.11 | 9.69 | 14 | 300932 | 10094 | 79433348 |
Eosinophil count increased | 10.10 | 9.69 | 32 | 300914 | 17073 | 79426369 |
Electroencephalogram abnormal | 10.10 | 9.69 | 44 | 300902 | 5390 | 79438052 |
Visceral oedema | 10.10 | 9.69 | 6 | 300940 | 111 | 79443331 |
Inappropriate schedule of product administration | 10.07 | 9.69 | 407 | 300539 | 133221 | 79310221 |
Scrotal infection | 10.07 | 9.69 | 12 | 300934 | 601 | 79442841 |
Disease prodromal stage | 10.04 | 9.69 | 5 | 300941 | 64 | 79443378 |
Hepatic pain | 10.01 | 9.69 | 36 | 300910 | 4036 | 79439406 |
Intraocular pressure increased | 9.98 | 9.69 | 12 | 300934 | 9193 | 79434249 |
Cholestatic liver injury | 9.95 | 9.69 | 41 | 300905 | 4900 | 79438542 |
Blood pressure diastolic increased | 9.90 | 9.69 | 91 | 300855 | 14451 | 79428991 |
General physical condition abnormal | 9.89 | 9.69 | 50 | 300896 | 6513 | 79436929 |
Acne | 9.89 | 9.69 | 61 | 300885 | 27129 | 79416313 |
Decerebration | 9.87 | 9.69 | 6 | 300940 | 116 | 79443326 |
Nerve injury | 9.86 | 9.69 | 65 | 300881 | 9327 | 79434115 |
Dysgeusia | 9.84 | 9.69 | 154 | 300792 | 57023 | 79386419 |
Faecaloma | 9.80 | 9.69 | 76 | 300870 | 11488 | 79431954 |
Incision site erythema | 9.80 | 9.69 | 11 | 300935 | 516 | 79442926 |
Clumsiness | 9.79 | 9.69 | 30 | 300916 | 3097 | 79440345 |
Blood creatine phosphokinase MB increased | 9.79 | 9.69 | 28 | 300918 | 2783 | 79440659 |
Urticaria aquagenic | 9.77 | 9.69 | 4 | 300942 | 31 | 79443411 |
Diplopia | 9.77 | 9.69 | 80 | 300866 | 33386 | 79410056 |
Medical device site haemorrhage | 9.77 | 9.69 | 7 | 300939 | 180 | 79443262 |
Skin papilloma | 9.76 | 9.69 | 5 | 300941 | 5881 | 79437561 |
Ileus paralytic | 9.76 | 9.69 | 66 | 300880 | 9554 | 79433888 |
Vulvovaginal candidiasis | 9.70 | 9.69 | 26 | 300920 | 2488 | 79440954 |
None
Source | Code | Description |
---|---|---|
ATC | A07DA52 | ALIMENTARY TRACT AND METABOLISM ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS ANTIPROPULSIVES Antipropulsives |
ATC | N02AA01 | NERVOUS SYSTEM ANALGESICS OPIOIDS Natural opium alkaloids |
ATC | N02AA51 | NERVOUS SYSTEM ANALGESICS OPIOIDS Natural opium alkaloids |
ATC | N02AG01 | NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with antispasmodics |
ATC | R05DA05 | RESPIRATORY SYSTEM COUGH AND COLD PREPARATIONS COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS Opium alkaloids and derivatives |
MeSH PA | D000700 | Analgesics |
MeSH PA | D000701 | Analgesics, Opioid |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D009294 | Narcotics |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
FDA MoA | N0000175684 | Full Opioid Agonists |
FDA EPC | N0000175690 | Opioid Agonist |
CHEBI has role | CHEBI:35482 | narcotic analgesic |
CHEBI has role | CHEBI:35620 | vasodilator agents |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:38867 | anaesthetic |
CHEBI has role | CHEBI:55322 | mu-opioid agonists |
CHEBI has role | CHEBI:76924 | plant metabolites |
CHEBI has role | CHEBI:78298 | environmental contaminants |
CHEBI has role | CHEBI:88188 | allergenic drug |
CHEBI has role | CHEBI:176497 | geroprotectors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Pain | indication | 22253000 | |
General anesthesia | indication | 50697003 | |
Diarrhea | indication | 62315008 | |
Severe pain | indication | 76948002 | |
Chronic pain | indication | 82423001 | |
Local anesthesia | indication | 386761002 | |
Acute postoperative pain | indication | 107401000119105 | |
Regional Anesthesia for Surgery | indication | ||
Regional Anesthesia for Labor Pain | indication | ||
Chronic Pain with Opioid Tolerance | indication | ||
Neuropathic pain | off-label use | 247398009 | |
Neonatal Abstinence Syndrome | off-label use | 414819007 | DOID:9828 |
Sedation in Intubated Patients | off-label use | ||
Neonatal Opioid Dependence | off-label use | ||
Brain damage | contraindication | 2470005 | |
Priapism | contraindication | 6273006 | DOID:9286 |
Tachyarrhythmia | contraindication | 6285003 | |
Urinary tract obstruction | contraindication | 7163005 | DOID:5200 |
Alcoholism | contraindication | 7200002 | |
Alcohol withdrawal delirium | contraindication | 8635005 | |
Dyskinesia | contraindication | 9748009 | |
Chronic obstructive lung disease | contraindication | 13645005 | DOID:3083 |
Severe chronic ulcerative colitis | contraindication | 14311001 | |
Chronic disease of respiratory system | contraindication | 17097001 | |
Acute vomiting | contraindication | 23971007 | |
Alcohol intoxication | contraindication | 25702006 | |
Shock | contraindication | 27942005 | |
Toxic megacolon | contraindication | 28536002 | DOID:1770 |
Orthostatic hypotension | contraindication | 28651003 | |
Atony of colon | contraindication | 29479008 | |
Hypercapnia | contraindication | 29596007 | |
Torsades de pointes | contraindication | 31722008 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Depressive disorder | contraindication | 35489007 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Disorder of gallbladder | contraindication | 39621005 | DOID:0060262 |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Complete trisomy 21 syndrome | contraindication | 41040004 | DOID:14250 |
Hypokalemia | contraindication | 43339004 | |
Low blood pressure | contraindication | 45007003 | |
Achalasia of esophagus | contraindication | 45564002 | DOID:9164 |
Chronic heart failure | contraindication | 48447003 | |
Paralytic ileus | contraindication | 55525008 | DOID:8442 |
Peptic reflux disease | contraindication | 57643001 | |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Cerebrovascular disease | contraindication | 62914000 | DOID:6713 |
Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
Drug AND/OR toxin-induced diarrhea | contraindication | 65979008 | |
Substance abuse | contraindication | 66214007 | |
Benign intracranial hypertension | contraindication | 68267002 | DOID:11459 |
Psychotic disorder | contraindication | 69322001 | |
Sleep apnea | contraindication | 73430006 | DOID:0050847 |
Pancreatitis | contraindication | 75694006 | DOID:4989 |
Urethral stricture | contraindication | 76618002 | |
Spastic paralysis | contraindication | 78403003 | |
Disturbance of salivary secretion | contraindication | 78948009 | |
Decreased respiratory function | contraindication | 80954004 | |
Injury of head | contraindication | 82271004 | |
Cor pulmonale | contraindication | 83291003 | DOID:8515 |
Hiatal hernia | contraindication | 84089009 | DOID:12642 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Disorder of biliary tract | contraindication | 105997008 | DOID:9741 |
Prolonged QT interval | contraindication | 111975006 | |
Gastrointestinal obstruction | contraindication | 126765001 | |
Seizure disorder | contraindication | 128613002 | |
Autonomic dysreflexia | contraindication | 129618003 | |
Bleeding | contraindication | 131148009 | |
Hypomagnesemia | contraindication | 190855004 | |
Alcohol withdrawal syndrome | contraindication | 191480000 | |
Drug-induced psychosis | contraindication | 191483003 | DOID:1742 |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Impaired renal function disorder | contraindication | 197663003 | |
Myocardial dysfunction | contraindication | 233928007 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Chronic diarrhea | contraindication | 236071009 | |
Bladder outflow obstruction | contraindication | 236645006 | |
Pyloric obstruction | contraindication | 244815007 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Drowsy | contraindication | 271782001 | |
Primary adrenocortical insufficiency | contraindication | 373662000 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Gastric ulcer | contraindication | 397825006 | DOID:10808 |
Chronic lung disease | contraindication | 413839001 | |
Disorder of coronary artery | contraindication | 414024009 | |
Central nervous system depression | contraindication | 418072004 | |
Congenital long QT syndrome | contraindication | 442917000 | |
Acute exacerbation of asthma | contraindication | 708038006 | |
Predisposition to Nausea and Vomiting | contraindication | ||
Progressive Angina Pectoris | contraindication | ||
Severe Nausea | contraindication | ||
Pain in Opioid Naive Patients | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.71 | acidic |
pKa2 | 8.38 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
100MG;4MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8685443 | July 3, 2025 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING A PLURALITY OF COMPOSITE SUBUNITS AS CLAIMED |
20MG;0.8MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8685443 | July 3, 2025 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING A PLURALITY OF COMPOSITE SUBUNITS AS CLAIMED |
30MG;1.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8685443 | July 3, 2025 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING A PLURALITY OF COMPOSITE SUBUNITS AS CLAIMED |
50MG;2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8685443 | July 3, 2025 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING A PLURALITY OF COMPOSITE SUBUNITS AS CLAIMED |
60MG;2.4MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8685443 | July 3, 2025 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING A PLURALITY OF COMPOSITE SUBUNITS AS CLAIMED |
80MG;3.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8685443 | July 3, 2025 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING A PLURALITY OF COMPOSITE SUBUNITS AS CLAIMED |
100MG;4MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 7682633 | June 19, 2027 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED. |
100MG;4MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8158156 | June 19, 2027 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED. |
20MG;0.8MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 7682633 | June 19, 2027 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED. |
20MG;0.8MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8158156 | June 19, 2027 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED. |
30MG;1.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 7682633 | June 19, 2027 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED. |
30MG;1.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8158156 | June 19, 2027 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED. |
50MG;2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 7682633 | June 19, 2027 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED. |
50MG;2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8158156 | June 19, 2027 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED. |
60MG;2.4MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 7682633 | June 19, 2027 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED. |
60MG;2.4MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8158156 | June 19, 2027 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED. |
80MG;3.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 7682633 | June 19, 2027 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED. |
80MG;3.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8158156 | June 19, 2027 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG TERM OPIOID TREATMENT BY ORALLY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED. |
100MG;4MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8623418 | Nov. 7, 2029 | TREATMENT OF MODERATE TO SEVERE CHRONIC PAIN BY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED |
20MG;0.8MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8623418 | Nov. 7, 2029 | TREATMENT OF MODERATE TO SEVERE CHRONIC PAIN BY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED |
30MG;1.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8623418 | Nov. 7, 2029 | TREATMENT OF MODERATE TO SEVERE CHRONIC PAIN BY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED |
50MG;2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8623418 | Nov. 7, 2029 | TREATMENT OF MODERATE TO SEVERE CHRONIC PAIN BY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED |
60MG;2.4MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8623418 | Nov. 7, 2029 | TREATMENT OF MODERATE TO SEVERE CHRONIC PAIN BY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED |
80MG;3.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons** | EMBEDA | ALPHARMA PHARMS | N022321 | Aug. 13, 2009 | DISCN | CAPSULE, EXTENDED RELEASE | ORAL | 8623418 | Nov. 7, 2029 | TREATMENT OF MODERATE TO SEVERE CHRONIC PAIN BY ADMINISTERING AN INTACT COMPOSITION AS CLAIMED |
15MG | ARYMO ER | ZYLA | N208603 | Jan. 9, 2017 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 9044402 | July 1, 2033 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE |
15MG | ARYMO ER | ZYLA | N208603 | Jan. 9, 2017 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 9549899 | July 1, 2033 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE |
30MG | ARYMO ER | ZYLA | N208603 | Jan. 9, 2017 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 9044402 | July 1, 2033 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE |
30MG | ARYMO ER | ZYLA | N208603 | Jan. 9, 2017 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 9549899 | July 1, 2033 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE |
60MG | ARYMO ER | ZYLA | N208603 | Jan. 9, 2017 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 9044402 | July 1, 2033 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE |
60MG | ARYMO ER | ZYLA | N208603 | Jan. 9, 2017 | DISCN | TABLET, EXTENDED RELEASE | ORAL | 9549899 | July 1, 2033 | MANAGEMENT OF PAIN SEVERE ENOUGH TO REQUIRE DAILY, AROUND-THE-CLOCK, LONG-TERM OPIOID TREATMENT AND FOR WHICH ALTERNATIVE TREATMENT OPTIONS ARE INADEQUATE |
10MG/ML (10MG/ML) | MORPHINE SULFATE | FRESENIUS KABI USA | N204223 | Oct. 30, 2013 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS | 9192608 | March 12, 2034 | MANAGEMENT OF CHRONIC PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA |
10MG/ML (10MG/ML) | MORPHINE SULFATE | FRESENIUS KABI USA | N204223 | Oct. 30, 2013 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS | 9192608 | March 12, 2034 | TREATMENT OF PAIN |
2MG/ML (2MG/ML) | MORPHINE SULFATE | FRESENIUS KABI USA | N204223 | Oct. 30, 2013 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS | 9192608 | March 12, 2034 | MANAGEMENT OF CHRONIC PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA |
2MG/ML (2MG/ML) | MORPHINE SULFATE | FRESENIUS KABI USA | N204223 | Oct. 30, 2013 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS | 9192608 | March 12, 2034 | TREATMENT OF PAIN |
4MG/ML (4MG/ML) | MORPHINE SULFATE | FRESENIUS KABI USA | N204223 | Oct. 30, 2013 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS | 9192608 | March 12, 2034 | MANAGEMENT OF CHRONIC PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA |
4MG/ML (4MG/ML) | MORPHINE SULFATE | FRESENIUS KABI USA | N204223 | Oct. 30, 2013 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS | 9192608 | March 12, 2034 | TREATMENT OF PAIN |
5MG/ML (5MG/ML) | MORPHINE SULFATE | FRESENIUS KABI USA | N204223 | Oct. 30, 2013 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS | 9192608 | March 12, 2034 | MANAGEMENT OF CHRONIC PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA |
5MG/ML (5MG/ML) | MORPHINE SULFATE | FRESENIUS KABI USA | N204223 | Oct. 30, 2013 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS | 9192608 | March 12, 2034 | TREATMENT OF PAIN |
8MG/ML (8MG/ML) | MORPHINE SULFATE | FRESENIUS KABI USA | N204223 | Oct. 30, 2013 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS | 9192608 | March 12, 2034 | MANAGEMENT OF CHRONIC PAIN IN PATIENTS REQUIRING OPIOID ANALGESIA |
8MG/ML (8MG/ML) | MORPHINE SULFATE | FRESENIUS KABI USA | N204223 | Oct. 30, 2013 | RX | SOLUTION | INTRAMUSCULAR, INTRAVENOUS | 9192608 | March 12, 2034 | TREATMENT OF PAIN |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
10MG/5ML | MORPHINE SULFATE | HIKMA | N022195 | March 17, 2008 | RX | SOLUTION | ORAL | June 2, 2024 | NEW PATIENT POPULATION |
20MG/5ML | MORPHINE SULFATE | HIKMA | N022195 | March 17, 2008 | RX | SOLUTION | ORAL | June 2, 2024 | NEW PATIENT POPULATION |
15MG | MORPHINE SULFATE | HIKMA | N022207 | March 17, 2008 | RX | TABLET | ORAL | June 2, 2024 | NEW PATIENT POPULATION |
30MG | MORPHINE SULFATE | HIKMA | N022207 | March 17, 2008 | RX | TABLET | ORAL | June 2, 2024 | NEW PATIENT POPULATION |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Mu-type opioid receptor | GPCR | AGONIST | EC50 | 7.86 | WOMBAT-PK | CHEMBL | |||
Kappa-type opioid receptor | GPCR | Ki | 6.97 | WOMBAT-PK | |||||
Delta-type opioid receptor | GPCR | Ki | 6.62 | WOMBAT-PK | |||||
Solute carrier family 22 member 1 | Transporter | IC50 | 4.55 | CHEMBL | |||||
Delta-type opioid receptor | GPCR | Ki | 7 | CHEMBL | |||||
Delta-type opioid receptor | GPCR | Ki | 8.74 | CHEMBL | |||||
Kappa-type opioid receptor | GPCR | Ki | 7.62 | CHEMBL | |||||
Kappa-type opioid receptor | GPCR | Ki | 7.57 | CHEMBL | |||||
Kappa-type opioid receptor | GPCR | Ki | 6.52 | CHEMBL | |||||
Mu-type opioid receptor | GPCR | Ki | 9.30 | CHEMBL | |||||
Nociceptin receptor | GPCR | Ki | 7.86 | CHEMBL | |||||
Opioid receptor | GPCR | Ki | 8.22 | CHEMBL | |||||
Dopamine receptor | GPCR | IC50 | 8.27 | CHEMBL | |||||
Opioid receptor | GPCR | IC50 | 7.57 | CHEMBL | |||||
Mu opioid receptor-like OR2 | GPCR | Ki | 6.73 | CHEMBL | |||||
Opioid receptor, delta 1b | GPCR | Ki | 5.85 | CHEMBL | |||||
Opioid receptor homologue | GPCR | Ki | 6.65 | CHEMBL | |||||
Mu-type opioid receptor | GPCR | Ki | 9.11 | CHEMBL | |||||
Mu-type opioid receptor | GPCR | Ki | 9.06 | CHEMBL | |||||
Mu-type opioid receptor | GPCR | Ki | 8.92 | CHEMBL |
ID | Source |
---|---|
D00842 | KEGG_DRUG |
52-26-6 | SECONDARY_CAS_RN |
6211-15-0 | SECONDARY_CAS_RN |
4017470 | VANDF |
4017530 | VANDF |
C0026549 | UMLSCUI |
CHEBI:17303 | CHEBI |
MOI | PDB_CHEM_ID |
CHEMBL70 | ChEMBL_ID |
CHEMBL556578 | ChEMBL_ID |
DB00295 | DRUGBANK_ID |
CHEMBL2103744 | ChEMBL_ID |
CHEMBL2096625 | ChEMBL_ID |
D009020 | MESH_DESCRIPTOR_UI |
5288826 | PUBCHEM_CID |
1627 | IUPHAR_LIGAND_ID |
76I7G6D29C | UNII |
235751 | RXNORM |
15239 | MMSL |
18643 | MMSL |
1913 | MMSL |
5136 | MMSL |
d00308 | MMSL |
d05295 | MMSL |
001545 | NDDF |
001546 | NDDF |
003523 | NDDF |
373529000 | SNOMEDCT_US |
395804007 | SNOMEDCT_US |
414779007 | SNOMEDCT_US |
60886004 | SNOMEDCT_US |
73572009 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6011 | CAPSULE, EXTENDED RELEASE | 10 mg | ORAL | NDA | 34 sections |
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6012 | CAPSULE, EXTENDED RELEASE | 20 mg | ORAL | NDA | 34 sections |
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6013 | CAPSULE, EXTENDED RELEASE | 30 mg | ORAL | NDA | 34 sections |
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6014 | CAPSULE, EXTENDED RELEASE | 40 mg | ORAL | NDA | 34 sections |
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6015 | CAPSULE, EXTENDED RELEASE | 50 mg | ORAL | NDA | 34 sections |
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6016 | CAPSULE, EXTENDED RELEASE | 60 mg | ORAL | NDA | 34 sections |
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6017 | CAPSULE, EXTENDED RELEASE | 80 mg | ORAL | NDA | 34 sections |
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6018 | CAPSULE, EXTENDED RELEASE | 100 mg | ORAL | NDA | 34 sections |
Kadian | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0023-6019 | CAPSULE, EXTENDED RELEASE | 200 mg | ORAL | NDA | 34 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0235 | TABLET | 15 mg | ORAL | NDA | 32 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0236 | TABLET | 30 mg | ORAL | NDA | 32 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0237 | SOLUTION | 10 mg | ORAL | NDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0237 | SOLUTION | 10 mg | ORAL | NDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0237 | SOLUTION | 10 mg | ORAL | NDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0238 | SOLUTION | 20 mg | ORAL | NDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0238 | SOLUTION | 20 mg | ORAL | NDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0238 | SOLUTION | 20 mg | ORAL | NDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0404 | SOLUTION | 100 mg | ORAL | NDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0404 | SOLUTION | 100 mg | ORAL | NDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0517 | SOLUTION | 100 mg | ORAL | NDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0517 | SOLUTION | 100 mg | ORAL | NDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1277 | CAPSULE, EXTENDED RELEASE | 20 mg | ORAL | ANDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1277 | CAPSULE, EXTENDED RELEASE | 20 mg | ORAL | ANDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1278 | CAPSULE, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1278 | CAPSULE, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1279 | CAPSULE, EXTENDED RELEASE | 50 mg | ORAL | ANDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1279 | CAPSULE, EXTENDED RELEASE | 50 mg | ORAL | ANDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1280 | CAPSULE, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1280 | CAPSULE, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 33 sections |
Morphine Sulfate | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1281 | CAPSULE, EXTENDED RELEASE | 80 mg | ORAL | ANDA | 33 sections |