morclofone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1841 31848-01-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • morclofone
  • dimeclophenone
  • dimecolphenone
  • nitux
  • Molecular weight: 405.88
  • Formula: C21H24ClNO5
  • CLOGP: 3.39
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 0
  • TPSA: 57.23
  • ALOGS: -4.48
  • ROTB: 8

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 80 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK1,JAK2,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MET,MTOR,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,TEK,TTK 46
kinase-selectivity-class ACVR2B,AXL,BRAF,DDR1,ERBB2,MAPK7,PDK4,SIK2 8
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R05DB25 RESPIRATORY SYSTEM
COUGH AND COLD PREPARATIONS
COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
Other cough suppressants
CHEBI has role CHEBI:51177 antitussive

Related Drugs by ATC class:

R05DB Other cough suppressants 25 drugs
benproperinebenzonatatebibenzoniumbutamirateclobutinolclofedanolcloperastinedibunatedimethoxanatedropropizinedroxypropinefedrilate show all 25 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.91 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07395 KEGG_DRUG
C0066796 UMLSCUI
CHEBI:135657 CHEBI
CHEMBL2105158 ChEMBL_ID
DB13558 DRUGBANK_ID
C037579 MESH_SUPPLEMENTAL_RECORD_UI
35949 PUBCHEM_CID
3277 INN_ID
VY62TIB872 UNII

Pharmaceutical products:

None