Stem definition | Drug id | CAS RN |
---|---|---|
leukotriene receptor antagonists | 1836 | 158966-92-8 |
Dose | Unit | Route |
---|---|---|
10 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.20 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.28 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 62 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.15 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 0.68 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.00 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 5 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Feb. 20, 1998 | FDA | MERCK |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Asthma | 5996.14 | 10.21 | 4069 | 185545 | 108701 | 55993752 |
Wheezing | 1918.44 | 10.21 | 1762 | 187852 | 73264 | 56029189 |
Eosinophilic granulomatosis with polyangiitis | 1273.65 | 10.21 | 411 | 189203 | 1650 | 56100803 |
Obstructive airways disorder | 847.03 | 10.21 | 595 | 189019 | 16687 | 56085766 |
Cough | 795.34 | 10.21 | 2293 | 187321 | 257668 | 55844785 |
Dyspnoea | 790.13 | 10.21 | 4004 | 185610 | 588573 | 55513880 |
Sputum discoloured | 638.17 | 10.21 | 465 | 189149 | 13827 | 56088626 |
Sleep disorder due to a general medical condition | 602.96 | 10.21 | 378 | 189236 | 8712 | 56093741 |
Productive cough | 577.96 | 10.21 | 824 | 188790 | 55408 | 56047045 |
Forced expiratory volume decreased | 522.57 | 10.21 | 273 | 189341 | 4387 | 56098066 |
Pemphigus | 506.74 | 10.21 | 4 | 189610 | 157208 | 55945245 |
Chest discomfort | 498.29 | 10.21 | 1057 | 188557 | 97800 | 56004653 |
Full blood count abnormal | 472.67 | 10.21 | 512 | 189102 | 25950 | 56076503 |
Synovitis | 433.01 | 10.21 | 28 | 189586 | 161277 | 55941176 |
Rheumatoid arthritis | 431.15 | 10.21 | 393 | 189221 | 382211 | 55720242 |
Hand deformity | 421.61 | 10.21 | 6 | 189608 | 134486 | 55967967 |
Urticaria | 388.31 | 10.21 | 1220 | 188394 | 143456 | 55958997 |
Systemic lupus erythematosus | 381.89 | 10.21 | 72 | 189542 | 180006 | 55922447 |
Glossodynia | 366.97 | 10.21 | 42 | 189572 | 152416 | 55950037 |
Toxicity to various agents | 344.17 | 10.21 | 163 | 189451 | 224401 | 55878052 |
Treatment failure | 333.03 | 10.21 | 82 | 189532 | 170310 | 55932143 |
Contraindicated product administered | 319.75 | 10.21 | 114 | 189500 | 186172 | 55916281 |
Bronchitis | 317.86 | 10.21 | 965 | 188649 | 111346 | 55991107 |
Arthropathy | 315.21 | 10.21 | 140 | 189474 | 200135 | 55902318 |
Sinusitis | 308.06 | 10.21 | 1400 | 188214 | 196181 | 55906272 |
Nasal congestion | 306.41 | 10.21 | 622 | 188992 | 55748 | 56046705 |
Pericarditis | 286.14 | 10.21 | 21 | 189593 | 108902 | 55993551 |
Drug intolerance | 285.10 | 10.21 | 283 | 189331 | 264535 | 55837918 |
Rhinitis allergic | 280.67 | 10.21 | 231 | 189383 | 8243 | 56094210 |
Upper respiratory tract infection | 274.76 | 10.21 | 686 | 188928 | 70602 | 56031851 |
Joint swelling | 269.24 | 10.21 | 349 | 189265 | 289451 | 55813002 |
Food allergy | 264.33 | 10.21 | 227 | 189387 | 8597 | 56093856 |
Chronic obstructive pulmonary disease | 260.77 | 10.21 | 589 | 189025 | 56826 | 56045627 |
Blood immunoglobulin E increased | 243.03 | 10.21 | 142 | 189472 | 2867 | 56099586 |
Wound | 231.29 | 10.21 | 89 | 189525 | 138715 | 55963738 |
Nasal polyps | 229.74 | 10.21 | 141 | 189473 | 3124 | 56099329 |
Asthmatic crisis | 226.16 | 10.21 | 112 | 189502 | 1598 | 56100855 |
Alopecia | 222.12 | 10.21 | 406 | 189208 | 293052 | 55809401 |
Infusion related reaction | 216.01 | 10.21 | 231 | 189383 | 208700 | 55893753 |
Therapeutic product effect decreased | 215.49 | 10.21 | 154 | 189460 | 169298 | 55933155 |
Middle insomnia | 213.44 | 10.21 | 222 | 189392 | 10728 | 56091725 |
Anaphylactic reaction | 212.03 | 10.21 | 553 | 189061 | 58442 | 56044011 |
Pneumonia | 211.65 | 10.21 | 2197 | 187417 | 404901 | 55697552 |
Sleep apnoea syndrome | 204.28 | 10.21 | 337 | 189277 | 25724 | 56076729 |
Nightmare | 202.06 | 10.21 | 266 | 189348 | 16560 | 56085893 |
Off label use | 201.34 | 10.21 | 1078 | 188536 | 555102 | 55547351 |
Seasonal allergy | 200.12 | 10.21 | 267 | 189347 | 16841 | 56085612 |
Helicobacter infection | 195.67 | 10.21 | 13 | 189601 | 73255 | 56029198 |
Gastrooesophageal reflux disease | 195.23 | 10.21 | 671 | 188943 | 82586 | 56019867 |
Temperature regulation disorder | 194.05 | 10.21 | 143 | 189471 | 4325 | 56098128 |
Maternal exposure during pregnancy | 193.24 | 10.21 | 212 | 189402 | 189341 | 55913112 |
Eosinophil count increased | 188.95 | 10.21 | 196 | 189418 | 9441 | 56093012 |
Neutropenia | 184.31 | 10.21 | 157 | 189457 | 158010 | 55944443 |
Influenza | 179.97 | 10.21 | 716 | 188898 | 94545 | 56007908 |
Breath sounds abnormal | 179.87 | 10.21 | 185 | 189429 | 8822 | 56093631 |
Impaired quality of life | 178.24 | 10.21 | 179 | 189435 | 8295 | 56094158 |
Dyspnoea exertional | 171.88 | 10.21 | 488 | 189126 | 54201 | 56048252 |
Therapeutic product effect incomplete | 171.50 | 10.21 | 760 | 188854 | 105271 | 55997182 |
Product dose omission issue | 166.85 | 10.21 | 1221 | 188393 | 203532 | 55898921 |
Polycystic ovaries | 164.41 | 10.21 | 115 | 189499 | 3199 | 56099254 |
Abdominal discomfort | 163.44 | 10.21 | 440 | 189174 | 276834 | 55825619 |
Completed suicide | 161.93 | 10.21 | 128 | 189486 | 133705 | 55968748 |
Muscle injury | 161.69 | 10.21 | 3 | 189611 | 52497 | 56049956 |
Product quality issue | 159.29 | 10.21 | 339 | 189275 | 31397 | 56071056 |
Acute kidney injury | 158.34 | 10.21 | 361 | 189253 | 240402 | 55862051 |
Folliculitis | 155.35 | 10.21 | 7 | 189607 | 54972 | 56047481 |
Respiratory tract infection | 154.86 | 10.21 | 362 | 189252 | 35709 | 56066744 |
Infective pulmonary exacerbation of cystic fibrosis | 147.66 | 10.21 | 159 | 189455 | 7998 | 56094455 |
Upper-airway cough syndrome | 146.87 | 10.21 | 170 | 189444 | 9268 | 56093185 |
Stomatitis | 141.84 | 10.21 | 119 | 189495 | 120691 | 55981762 |
Impaired healing | 139.20 | 10.21 | 59 | 189555 | 86782 | 56015671 |
Sleep terror | 138.49 | 10.21 | 62 | 189552 | 694 | 56101759 |
Sensitisation | 136.09 | 10.21 | 90 | 189524 | 2278 | 56100175 |
Malignant neoplasm progression | 135.02 | 10.21 | 40 | 189574 | 73547 | 56028906 |
General physical health deterioration | 135.00 | 10.21 | 228 | 189386 | 169782 | 55932671 |
Pancytopenia | 134.82 | 10.21 | 65 | 189549 | 88650 | 56013803 |
Rhinorrhoea | 134.81 | 10.21 | 461 | 189153 | 56576 | 56045877 |
Coeliac disease | 134.40 | 10.21 | 170 | 189444 | 10169 | 56092284 |
Chronic spontaneous urticaria | 134.35 | 10.21 | 68 | 189546 | 1019 | 56101434 |
Anaemia | 131.63 | 10.21 | 461 | 189153 | 267050 | 55835403 |
Bronchospasm | 130.10 | 10.21 | 208 | 189406 | 15461 | 56086992 |
Rhinitis | 129.45 | 10.21 | 155 | 189459 | 8761 | 56093692 |
Secretion discharge | 128.61 | 10.21 | 168 | 189446 | 10378 | 56092075 |
Drug interaction | 124.93 | 10.21 | 331 | 189283 | 209424 | 55893029 |
Drug ineffective | 124.19 | 10.21 | 2267 | 187347 | 916722 | 55185731 |
Thrombocytopenia | 123.29 | 10.21 | 167 | 189447 | 136057 | 55966396 |
Drug abuse | 121.79 | 10.21 | 38 | 189576 | 67572 | 56034881 |
Loss of personal independence in daily activities | 121.67 | 10.21 | 570 | 189044 | 80799 | 56021654 |
Headache | 117.72 | 10.21 | 2583 | 187031 | 556461 | 55545992 |
Blood test abnormal | 117.72 | 10.21 | 178 | 189436 | 12606 | 56089847 |
Death | 113.32 | 10.21 | 680 | 188934 | 340746 | 55761707 |
Febrile neutropenia | 112.01 | 10.21 | 114 | 189500 | 105431 | 55997022 |
Suicidal ideation | 111.41 | 10.21 | 437 | 189177 | 57305 | 56045148 |
Swelling | 109.53 | 10.21 | 426 | 189188 | 239345 | 55863108 |
Dysphonia | 108.89 | 10.21 | 350 | 189264 | 41597 | 56060856 |
Respiratory tract congestion | 106.89 | 10.21 | 190 | 189424 | 15401 | 56087052 |
Discomfort | 106.30 | 10.21 | 197 | 189417 | 141564 | 55960889 |
Reversible airways obstruction | 105.71 | 10.21 | 63 | 189551 | 1321 | 56101132 |
Oropharyngeal pain | 105.47 | 10.21 | 559 | 189055 | 83229 | 56019224 |
Perfume sensitivity | 104.60 | 10.21 | 50 | 189564 | 657 | 56101796 |
Heart rate increased | 104.43 | 10.21 | 555 | 189059 | 82718 | 56019735 |
Eczema | 104.20 | 10.21 | 255 | 189359 | 25898 | 56076555 |
Anxiety | 103.56 | 10.21 | 1050 | 188564 | 192122 | 55910331 |
Aggression | 103.49 | 10.21 | 229 | 189385 | 21777 | 56080676 |
Ejection fraction | 102.99 | 10.21 | 67 | 189547 | 1648 | 56100805 |
Musculoskeletal stiffness | 102.41 | 10.21 | 234 | 189380 | 155773 | 55946680 |
Vital capacity decreased | 101.96 | 10.21 | 60 | 189554 | 1228 | 56101225 |
Peak expiratory flow rate decreased | 101.88 | 10.21 | 47 | 189567 | 567 | 56101886 |
Sputum increased | 101.41 | 10.21 | 72 | 189542 | 2052 | 56100401 |
Hyponatraemia | 97.78 | 10.21 | 120 | 189494 | 102019 | 56000434 |
Blister | 95.99 | 10.21 | 136 | 189478 | 108751 | 55993702 |
Lung hyperinflation | 95.34 | 10.21 | 56 | 189558 | 1142 | 56101311 |
Pruritus | 93.63 | 10.21 | 1542 | 188072 | 315081 | 55787372 |
Hepatic enzyme increased | 93.49 | 10.21 | 282 | 189332 | 171102 | 55931351 |
Dermatitis atopic | 93.21 | 10.21 | 127 | 189487 | 8172 | 56094281 |
Total lung capacity increased | 92.96 | 10.21 | 51 | 189563 | 908 | 56101545 |
Status asthmaticus | 92.72 | 10.21 | 50 | 189564 | 859 | 56101594 |
Throat clearing | 92.44 | 10.21 | 60 | 189554 | 1470 | 56100983 |
Eosinophilia | 92.25 | 10.21 | 207 | 189407 | 19870 | 56082583 |
Disease progression | 92.08 | 10.21 | 132 | 189482 | 105041 | 55997412 |
C-reactive protein abnormal | 91.42 | 10.21 | 9 | 189605 | 36800 | 56065653 |
Bronchial secretion retention | 88.44 | 10.21 | 63 | 189551 | 1805 | 56100648 |
Sinus disorder | 87.80 | 10.21 | 207 | 189407 | 20527 | 56081926 |
Angioedema | 86.77 | 10.21 | 322 | 189292 | 41131 | 56061322 |
Sleep disorder due to general medical condition, insomnia type | 86.27 | 10.21 | 20 | 189594 | 43318 | 56059135 |
Immunodeficiency | 86.21 | 10.21 | 177 | 189437 | 15980 | 56086473 |
Illness | 86.01 | 10.21 | 284 | 189330 | 34227 | 56068226 |
Respiratory rate increased | 85.01 | 10.21 | 150 | 189464 | 12087 | 56090366 |
C-reactive protein increased | 84.60 | 10.21 | 84 | 189530 | 78600 | 56023853 |
Sensitivity to weather change | 84.32 | 10.21 | 108 | 189506 | 6541 | 56095912 |
Leukopenia | 84.32 | 10.21 | 69 | 189545 | 70871 | 56031582 |
Dust allergy | 83.47 | 10.21 | 41 | 189573 | 574 | 56101879 |
Rales | 83.36 | 10.21 | 139 | 189475 | 10701 | 56091752 |
Forced vital capacity decreased | 82.63 | 10.21 | 48 | 189566 | 958 | 56101495 |
Intentional product use issue | 82.63 | 10.21 | 130 | 189484 | 99603 | 56002850 |
Abnormal behaviour | 80.06 | 10.21 | 197 | 189417 | 20075 | 56082378 |
Multiple organ dysfunction syndrome | 79.65 | 10.21 | 39 | 189575 | 52731 | 56049722 |
Nasal oedema | 77.16 | 10.21 | 48 | 189566 | 1090 | 56101363 |
Respiration abnormal | 76.91 | 10.21 | 95 | 189519 | 5546 | 56096907 |
Sneezing | 76.67 | 10.21 | 165 | 189449 | 15395 | 56087058 |
Eye pruritus | 76.24 | 10.21 | 156 | 189458 | 14050 | 56088403 |
Mucosal inflammation | 75.43 | 10.21 | 25 | 189589 | 42785 | 56059668 |
Multiple allergies | 74.65 | 10.21 | 130 | 189484 | 10366 | 56092087 |
Intentional overdose | 74.06 | 10.21 | 72 | 189542 | 68045 | 56034408 |
Gastrointestinal disorder | 73.97 | 10.21 | 169 | 189445 | 112533 | 55989920 |
Hypotension | 73.82 | 10.21 | 517 | 189097 | 249991 | 55852462 |
Chronic sinusitis | 73.40 | 10.21 | 114 | 189500 | 8264 | 56094189 |
Irritable bowel syndrome | 72.55 | 10.21 | 74 | 189540 | 68384 | 56034069 |
Confusional state | 72.46 | 10.21 | 408 | 189206 | 207747 | 55894706 |
Renal impairment | 71.94 | 10.21 | 100 | 189514 | 80613 | 56021840 |
Blood pressure systolic increased | 70.78 | 10.21 | 299 | 189315 | 40537 | 56061916 |
Liver injury | 69.37 | 10.21 | 27 | 189587 | 41821 | 56060632 |
Respiratory symptom | 68.18 | 10.21 | 64 | 189550 | 2726 | 56099727 |
Throat irritation | 67.66 | 10.21 | 253 | 189361 | 32430 | 56070023 |
Sinus congestion | 66.59 | 10.21 | 157 | 189457 | 15567 | 56086886 |
Emphysema | 66.37 | 10.21 | 120 | 189494 | 9856 | 56092597 |
Throat tightness | 65.61 | 10.21 | 195 | 189419 | 22212 | 56080241 |
Septic shock | 65.33 | 10.21 | 65 | 189549 | 60770 | 56041683 |
Crying | 65.08 | 10.21 | 189 | 189425 | 21251 | 56081202 |
Pulmonary function test decreased | 65.00 | 10.21 | 70 | 189544 | 3521 | 56098932 |
Coma | 64.92 | 10.21 | 63 | 189551 | 59592 | 56042861 |
Poor quality device used | 64.57 | 10.21 | 53 | 189561 | 1883 | 56100570 |
Rhonchi | 64.30 | 10.21 | 58 | 189556 | 2346 | 56100107 |
Rash erythematous | 63.32 | 10.21 | 271 | 189343 | 36950 | 56065503 |
Abnormal dreams | 62.84 | 10.21 | 115 | 189499 | 9534 | 56092919 |
Bradycardia | 62.83 | 10.21 | 81 | 189533 | 67423 | 56035030 |
Malaise | 62.67 | 10.21 | 1652 | 187962 | 366208 | 55736245 |
Pulmonary function test abnormal | 62.08 | 10.21 | 46 | 189568 | 1403 | 56101050 |
Toxic epidermal necrolysis | 61.63 | 10.21 | 3 | 189611 | 22039 | 56080414 |
Bone marrow failure | 60.55 | 10.21 | 11 | 189603 | 28275 | 56074178 |
Depressed level of consciousness | 59.80 | 10.21 | 61 | 189553 | 56372 | 56046081 |
Pulmonary mass | 59.80 | 10.21 | 178 | 189436 | 20292 | 56082161 |
Blood pressure increased | 59.53 | 10.21 | 749 | 188865 | 144427 | 55958026 |
Sinusitis fungal | 59.32 | 10.21 | 46 | 189568 | 1504 | 56100949 |
Diarrhoea | 58.87 | 10.21 | 1670 | 187944 | 636837 | 55465616 |
Bronchial disorder | 58.56 | 10.21 | 41 | 189573 | 1142 | 56101311 |
Red blood cell sedimentation rate increased | 58.48 | 10.21 | 25 | 189589 | 36598 | 56065855 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 58.16 | 10.21 | 34 | 189580 | 687 | 56101766 |
Metabolic acidosis | 57.93 | 10.21 | 32 | 189582 | 40422 | 56062031 |
Nasal discharge discolouration | 57.89 | 10.21 | 49 | 189565 | 1818 | 56100635 |
Hypokalaemia | 57.70 | 10.21 | 147 | 189467 | 94290 | 56008163 |
Asthma exercise induced | 57.62 | 10.21 | 25 | 189589 | 258 | 56102195 |
Bronchial obstruction | 57.09 | 10.21 | 43 | 189571 | 1345 | 56101108 |
Insomnia | 55.71 | 10.21 | 932 | 188682 | 190928 | 55911525 |
Cystic fibrosis | 55.21 | 10.21 | 63 | 189551 | 3381 | 56099072 |
Bronchial neoplasm | 54.14 | 10.21 | 28 | 189586 | 440 | 56102013 |
Factor V Leiden mutation | 54.03 | 10.21 | 22 | 189592 | 191 | 56102262 |
Infusion site swelling | 53.61 | 10.21 | 96 | 189518 | 7825 | 56094628 |
Restrictive pulmonary disease | 53.48 | 10.21 | 43 | 189571 | 1483 | 56100970 |
Infusion site pruritus | 53.14 | 10.21 | 73 | 189541 | 4734 | 56097719 |
Respiratory disorder | 53.03 | 10.21 | 241 | 189373 | 33716 | 56068737 |
Migraine | 52.94 | 10.21 | 485 | 189129 | 86312 | 56016141 |
Nasal obstruction | 52.00 | 10.21 | 39 | 189575 | 1212 | 56101241 |
Haemoglobin decreased | 51.64 | 10.21 | 254 | 189360 | 133883 | 55968570 |
Allergy to animal | 51.04 | 10.21 | 35 | 189579 | 942 | 56101511 |
Infusion site erythema | 50.97 | 10.21 | 105 | 189509 | 9501 | 56092952 |
Nasal turbinate hypertrophy | 50.70 | 10.21 | 31 | 189583 | 682 | 56101771 |
Hyperkalaemia | 50.54 | 10.21 | 58 | 189556 | 50807 | 56051646 |
Nasopharyngitis | 50.45 | 10.21 | 1034 | 188580 | 219925 | 55882528 |
Hyper IgE syndrome | 50.19 | 10.21 | 26 | 189588 | 410 | 56102043 |
Bronchial haemorrhage | 49.56 | 10.21 | 28 | 189586 | 529 | 56101924 |
Mast cell activation syndrome | 48.98 | 10.21 | 30 | 189584 | 662 | 56101791 |
Aspirin-exacerbated respiratory disease | 48.92 | 10.21 | 33 | 189581 | 864 | 56101589 |
Mood altered | 48.78 | 10.21 | 126 | 189488 | 13229 | 56089224 |
Sputum culture positive | 48.58 | 10.21 | 43 | 189571 | 1696 | 56100757 |
Cardiac failure | 48.46 | 10.21 | 130 | 189484 | 81963 | 56020490 |
COVID-19 | 48.13 | 10.21 | 424 | 189190 | 74634 | 56027819 |
Metastases to bone | 47.84 | 10.21 | 5 | 189609 | 19503 | 56082950 |
Feeling abnormal | 47.60 | 10.21 | 672 | 188942 | 132930 | 55969523 |
Hypoventilation | 47.50 | 10.21 | 66 | 189548 | 4326 | 56098127 |
Salpingo-oophorectomy unilateral | 46.44 | 10.21 | 29 | 189585 | 663 | 56101790 |
Nephrectomy | 46.42 | 10.21 | 36 | 189578 | 1177 | 56101276 |
Bursitis | 46.28 | 10.21 | 200 | 189414 | 27382 | 56075071 |
Aphonia | 45.93 | 10.21 | 97 | 189517 | 8932 | 56093521 |
Smoke sensitivity | 45.80 | 10.21 | 24 | 189590 | 388 | 56102065 |
Mobility decreased | 45.69 | 10.21 | 175 | 189439 | 98816 | 56003637 |
Hip arthroplasty | 45.35 | 10.21 | 38 | 189576 | 38585 | 56063868 |
Ascites | 45.25 | 10.21 | 36 | 189578 | 37508 | 56064945 |
Idiopathic intracranial hypertension | 44.85 | 10.21 | 49 | 189565 | 2505 | 56099948 |
Prolonged expiration | 44.67 | 10.21 | 31 | 189583 | 851 | 56101602 |
Frustration tolerance decreased | 44.29 | 10.21 | 78 | 189536 | 6275 | 56096178 |
Viral infection | 44.26 | 10.21 | 219 | 189395 | 31727 | 56070726 |
Alanine aminotransferase increased | 43.60 | 10.21 | 165 | 189449 | 93497 | 56008956 |
Arthralgia | 43.41 | 10.21 | 1323 | 188291 | 500346 | 55602107 |
Live birth | 43.34 | 10.21 | 7 | 189607 | 19598 | 56082855 |
Carpal tunnel syndrome | 43.15 | 10.21 | 147 | 189467 | 17997 | 56084456 |
Humidity intolerance | 43.01 | 10.21 | 21 | 189593 | 290 | 56102163 |
Sopor | 42.96 | 10.21 | 9 | 189605 | 20913 | 56081540 |
Product use issue | 42.84 | 10.21 | 410 | 189204 | 185631 | 55916822 |
Depression | 42.80 | 10.21 | 848 | 188766 | 179269 | 55923184 |
Hepatotoxicity | 42.68 | 10.21 | 26 | 189588 | 31127 | 56071326 |
Neoplasm progression | 42.10 | 10.21 | 28 | 189586 | 31988 | 56070465 |
Scratch | 41.95 | 10.21 | 71 | 189543 | 5532 | 56096921 |
Bronchiectasis | 41.89 | 10.21 | 108 | 189506 | 11326 | 56091127 |
Mood swings | 41.88 | 10.21 | 138 | 189476 | 16609 | 56085844 |
Haemoptysis | 41.85 | 10.21 | 189 | 189425 | 26371 | 56076082 |
Platelet count decreased | 41.77 | 10.21 | 200 | 189414 | 106183 | 55996270 |
Neurotoxicity | 41.58 | 10.21 | 3 | 189611 | 15792 | 56086661 |
Anger | 41.48 | 10.21 | 109 | 189505 | 11563 | 56090890 |
Atopy | 41.27 | 10.21 | 19 | 189595 | 228 | 56102225 |
Poor quality sleep | 40.61 | 10.21 | 142 | 189472 | 17613 | 56084840 |
Urticaria chronic | 40.49 | 10.21 | 25 | 189589 | 560 | 56101893 |
Sepsis | 39.97 | 10.21 | 291 | 189323 | 139549 | 55962904 |
Cholecystitis chronic | 39.84 | 10.21 | 96 | 189518 | 9652 | 56092801 |
Inappropriate schedule of product administration | 39.80 | 10.21 | 443 | 189171 | 82944 | 56019509 |
Product use in unapproved indication | 39.73 | 10.21 | 681 | 188933 | 140141 | 55962312 |
Inflammation | 39.55 | 10.21 | 111 | 189503 | 68960 | 56033493 |
Hereditary angioedema | 38.99 | 10.21 | 77 | 189537 | 6758 | 56095695 |
Bronchopulmonary aspergillosis allergic | 38.90 | 10.21 | 35 | 189579 | 1411 | 56101042 |
Burning sensation | 38.76 | 10.21 | 289 | 189325 | 48407 | 56054046 |
Swelling face | 38.71 | 10.21 | 322 | 189292 | 55747 | 56046706 |
Skin plaque | 38.61 | 10.21 | 78 | 189536 | 6960 | 56095493 |
Liver disorder | 38.51 | 10.21 | 56 | 189558 | 44314 | 56058139 |
Knee arthroplasty | 38.27 | 10.21 | 56 | 189558 | 44203 | 56058250 |
Vocal cord dysfunction | 38.02 | 10.21 | 21 | 189593 | 379 | 56102074 |
Total lung capacity decreased | 38.02 | 10.21 | 35 | 189579 | 1454 | 56100999 |
Cardio-respiratory arrest | 37.89 | 10.21 | 81 | 189533 | 55240 | 56047213 |
Infusion site pain | 37.69 | 10.21 | 117 | 189497 | 13645 | 56088808 |
Increased bronchial secretion | 37.63 | 10.21 | 36 | 189578 | 1571 | 56100882 |
Metastases to liver | 37.34 | 10.21 | 13 | 189601 | 21573 | 56080880 |
Therapy non-responder | 37.09 | 10.21 | 96 | 189518 | 61259 | 56041194 |
Fluid retention | 37.03 | 10.21 | 310 | 189304 | 53768 | 56048685 |
FEV1/FVC ratio decreased | 36.89 | 10.21 | 13 | 189601 | 72 | 56102381 |
Pain | 36.79 | 10.21 | 1843 | 187771 | 661341 | 55441112 |
Lipohypertrophy | 36.55 | 10.21 | 24 | 189590 | 600 | 56101853 |
Bone erosion | 36.31 | 10.21 | 4 | 189610 | 14970 | 56087483 |
Cytomegalovirus infection | 36.29 | 10.21 | 10 | 189604 | 19286 | 56083167 |
Palmar-plantar erythrodysaesthesia syndrome | 35.90 | 10.21 | 13 | 189601 | 21052 | 56081401 |
Decreased appetite | 35.85 | 10.21 | 521 | 189093 | 218710 | 55883743 |
Body tinea | 35.52 | 10.21 | 33 | 189581 | 1387 | 56101066 |
Acute myeloid leukaemia | 35.47 | 10.21 | 7 | 189607 | 16965 | 56085488 |
Agranulocytosis | 35.34 | 10.21 | 16 | 189598 | 22643 | 56079810 |
Hepatocellular injury | 35.12 | 10.21 | 23 | 189591 | 26491 | 56075962 |
Creatinine renal clearance decreased | 35.02 | 10.21 | 4 | 189610 | 14555 | 56087898 |
Endometrial ablation | 34.94 | 10.21 | 27 | 189587 | 878 | 56101575 |
Mastocytosis | 34.77 | 10.21 | 22 | 189592 | 515 | 56101938 |
Lactic acidosis | 34.37 | 10.21 | 41 | 189573 | 35305 | 56067148 |
White blood cell count decreased | 34.19 | 10.21 | 266 | 189348 | 125724 | 55976729 |
Drug tolerance decreased | 34.04 | 10.21 | 3 | 189611 | 13408 | 56089045 |
Erythema | 33.69 | 10.21 | 724 | 188890 | 155215 | 55947238 |
Eosinophil count abnormal | 33.52 | 10.21 | 21 | 189593 | 483 | 56101970 |
Cholestasis | 33.46 | 10.21 | 25 | 189589 | 26888 | 56075565 |
Oxygen saturation decreased | 33.27 | 10.21 | 410 | 189204 | 78657 | 56023796 |
Skin ulcer | 33.24 | 10.21 | 49 | 189565 | 38559 | 56063894 |
Ear pruritus | 33.17 | 10.21 | 45 | 189569 | 2883 | 56099570 |
Biliary dyskinesia | 33.08 | 10.21 | 42 | 189572 | 2521 | 56099932 |
Inhibitory drug interaction | 32.80 | 10.21 | 40 | 189574 | 2304 | 56100149 |
Aspartate aminotransferase increased | 32.59 | 10.21 | 155 | 189459 | 82447 | 56020006 |
Rash | 32.39 | 10.21 | 1345 | 188269 | 491702 | 55610751 |
Encephalopathy | 32.24 | 10.21 | 43 | 189571 | 35282 | 56067171 |
Pulmonary pain | 32.23 | 10.21 | 44 | 189570 | 2836 | 56099617 |
Gastrointestinal haemorrhage | 32.07 | 10.21 | 139 | 189475 | 75812 | 56026641 |
Dehydration | 32.06 | 10.21 | 361 | 189253 | 158464 | 55943989 |
Bronchitis chronic | 31.82 | 10.21 | 52 | 189562 | 3936 | 56098517 |
Infection | 31.62 | 10.21 | 479 | 189135 | 199727 | 55902726 |
Heart sounds | 31.42 | 10.21 | 24 | 189590 | 767 | 56101686 |
Cardiac arrest | 31.19 | 10.21 | 167 | 189447 | 86147 | 56016306 |
Increased viscosity of bronchial secretion | 31.07 | 10.21 | 16 | 189598 | 249 | 56102204 |
Ear infection | 31.00 | 10.21 | 196 | 189418 | 31099 | 56071354 |
Irritability | 31.00 | 10.21 | 188 | 189426 | 29400 | 56073053 |
Neutrophil count decreased | 30.85 | 10.21 | 77 | 189537 | 49745 | 56052708 |
Respiratory tract inflammation | 30.79 | 10.21 | 21 | 189593 | 560 | 56101893 |
Anosmia | 30.48 | 10.21 | 54 | 189560 | 4365 | 56098088 |
Blood creatinine increased | 30.19 | 10.21 | 153 | 189461 | 80038 | 56022415 |
Pharyngeal oedema | 30.17 | 10.21 | 106 | 189508 | 13179 | 56089274 |
Chest pain | 30.13 | 10.21 | 845 | 188769 | 188952 | 55913501 |
Swollen tongue | 30.09 | 10.21 | 190 | 189424 | 30134 | 56072319 |
Spirometry abnormal | 30.04 | 10.21 | 15 | 189599 | 218 | 56102235 |
Eosinophilic pneumonia | 29.74 | 10.21 | 35 | 189579 | 1942 | 56100511 |
Condition aggravated | 29.66 | 10.21 | 910 | 188704 | 343988 | 55758465 |
Embolism venous | 29.61 | 10.21 | 42 | 189572 | 2806 | 56099647 |
Infusion site extravasation | 29.51 | 10.21 | 77 | 189537 | 8133 | 56094320 |
Circulatory collapse | 29.00 | 10.21 | 17 | 189597 | 20786 | 56081667 |
Infection susceptibility increased | 28.88 | 10.21 | 41 | 189573 | 2742 | 56099711 |
Colitis | 28.81 | 10.21 | 61 | 189553 | 41750 | 56060703 |
Blood cholesterol increased | 28.75 | 10.21 | 136 | 189478 | 72443 | 56030010 |
Stress | 28.58 | 10.21 | 314 | 189300 | 58596 | 56043857 |
Neutropenic sepsis | 28.31 | 10.21 | 8 | 189606 | 15177 | 56087276 |
Lip swelling | 28.20 | 10.21 | 168 | 189446 | 26104 | 56076349 |
Osteonecrosis of jaw | 28.07 | 10.21 | 43 | 189571 | 33315 | 56069138 |
Infusion site haemorrhage | 27.90 | 10.21 | 47 | 189567 | 3648 | 56098805 |
Cardiac disorder | 27.76 | 10.21 | 256 | 189358 | 45631 | 56056822 |
Interstitial lung disease | 27.55 | 10.21 | 99 | 189515 | 56964 | 56045489 |
Occupational asthma | 27.48 | 10.21 | 12 | 189602 | 126 | 56102327 |
Neurosensory hypoacusis | 27.47 | 10.21 | 14 | 189600 | 213 | 56102240 |
Psoriatic arthropathy | 27.40 | 10.21 | 142 | 189472 | 73866 | 56028587 |
Disseminated intravascular coagulation | 27.32 | 10.21 | 13 | 189601 | 17872 | 56084581 |
Hypocalcaemia | 27.29 | 10.21 | 34 | 189580 | 28726 | 56073727 |
Mite allergy | 27.08 | 10.21 | 19 | 189595 | 531 | 56101922 |
Respiratory gas exchange disorder | 27.08 | 10.21 | 16 | 189598 | 330 | 56102123 |
Pneumonia aspiration | 27.06 | 10.21 | 42 | 189572 | 32369 | 56070084 |
Delirium | 26.88 | 10.21 | 65 | 189549 | 42452 | 56060001 |
Glucose tolerance impaired | 26.69 | 10.21 | 58 | 189556 | 5447 | 56097006 |
Rash maculo-papular | 26.57 | 10.21 | 35 | 189579 | 28872 | 56073581 |
Hypomagnesaemia | 26.54 | 10.21 | 27 | 189587 | 24988 | 56077465 |
Renal failure | 26.50 | 10.21 | 241 | 189373 | 110259 | 55992194 |
Anuria | 26.44 | 10.21 | 4 | 189610 | 11756 | 56090697 |
Ejection fraction abnormal | 26.44 | 10.21 | 25 | 189589 | 1075 | 56101378 |
Quality of life decreased | 26.28 | 10.21 | 67 | 189547 | 6978 | 56095475 |
Hypercapnia | 26.21 | 10.21 | 55 | 189559 | 5041 | 56097412 |
Drug level increased | 26.09 | 10.21 | 19 | 189595 | 20706 | 56081747 |
Affective disorder | 25.99 | 10.21 | 58 | 189556 | 5545 | 56096908 |
Orthostatic hypotension | 25.88 | 10.21 | 45 | 189569 | 33154 | 56069299 |
Rhabdomyolysis | 25.83 | 10.21 | 62 | 189552 | 40596 | 56061857 |
Pneumothorax spontaneous | 25.76 | 10.21 | 21 | 189593 | 739 | 56101714 |
Breast cancer metastatic | 25.60 | 10.21 | 10 | 189604 | 15459 | 56086994 |
Blood creatine phosphokinase increased | 25.53 | 10.21 | 34 | 189580 | 27918 | 56074535 |
Lymphocyte count decreased | 25.50 | 10.21 | 34 | 189580 | 27905 | 56074548 |
Paranasal sinus discomfort | 25.48 | 10.21 | 43 | 189571 | 3342 | 56099111 |
Increased upper airway secretion | 24.91 | 10.21 | 42 | 189572 | 3262 | 56099191 |
Pharyngeal swelling | 24.70 | 10.21 | 55 | 189559 | 5251 | 56097202 |
Nocturnal fear | 24.04 | 10.21 | 6 | 189608 | 6 | 56102447 |
Ear discomfort | 23.94 | 10.21 | 65 | 189549 | 7030 | 56095423 |
Influenza like illness | 23.84 | 10.21 | 312 | 189302 | 60676 | 56041777 |
Ankle fracture | 23.83 | 10.21 | 114 | 189500 | 16289 | 56086164 |
Vomiting | 23.76 | 10.21 | 1405 | 188209 | 496823 | 55605630 |
Infusion site urticaria | 23.73 | 10.21 | 25 | 189589 | 1226 | 56101227 |
Premature delivery | 23.63 | 10.21 | 34 | 189580 | 27026 | 56075427 |
Lung opacity | 23.57 | 10.21 | 34 | 189580 | 2307 | 56100146 |
Pharyngitis streptococcal | 23.51 | 10.21 | 78 | 189536 | 9420 | 56093033 |
Gamma-glutamyltransferase increased | 23.29 | 10.21 | 43 | 189571 | 30962 | 56071491 |
Peripheral swelling | 23.03 | 10.21 | 608 | 189006 | 234118 | 55868335 |
Joint range of motion decreased | 23.02 | 10.21 | 31 | 189583 | 25334 | 56077119 |
Progressive multifocal leukoencephalopathy | 23.02 | 10.21 | 6 | 189608 | 12007 | 56090446 |
Hepatic failure | 22.95 | 10.21 | 49 | 189565 | 33437 | 56069016 |
Infusion site bruising | 22.92 | 10.21 | 37 | 189577 | 2772 | 56099681 |
Palpitations | 22.89 | 10.21 | 467 | 189147 | 99205 | 56003248 |
Acute respiratory distress syndrome | 22.89 | 10.21 | 24 | 189590 | 21902 | 56080551 |
Bronchial hyperreactivity | 22.77 | 10.21 | 27 | 189587 | 1510 | 56100943 |
Mononeuropathy multiplex | 22.71 | 10.21 | 13 | 189601 | 252 | 56102201 |
Spinal operation | 22.47 | 10.21 | 65 | 189549 | 7291 | 56095162 |
Product substitution issue | 22.34 | 10.21 | 103 | 189511 | 14496 | 56087957 |
Hyperhidrosis | 22.33 | 10.21 | 443 | 189171 | 93645 | 56008808 |
Separation anxiety disorder | 22.32 | 10.21 | 7 | 189607 | 25 | 56102428 |
Ligament pain | 22.21 | 10.21 | 12 | 189602 | 207 | 56102246 |
Allergy test positive | 22.16 | 10.21 | 15 | 189599 | 395 | 56102058 |
Lacrimation increased | 22.10 | 10.21 | 121 | 189493 | 18227 | 56084226 |
Oral allergy syndrome | 21.91 | 10.21 | 7 | 189607 | 27 | 56102426 |
Incorrect dose administered | 21.89 | 10.21 | 272 | 189342 | 52275 | 56050178 |
Blood bilirubin increased | 21.88 | 10.21 | 50 | 189564 | 33304 | 56069149 |
Lung diffusion test decreased | 21.75 | 10.21 | 18 | 189596 | 647 | 56101806 |
Somnambulism | 21.73 | 10.21 | 51 | 189563 | 5041 | 56097412 |
Hepatic function abnormal | 21.72 | 10.21 | 53 | 189561 | 34505 | 56067948 |
Pulmonary arterial hypertension | 21.51 | 10.21 | 35 | 189579 | 26468 | 56075985 |
Neuroleptic malignant syndrome | 21.49 | 10.21 | 6 | 189608 | 11472 | 56090981 |
Serotonin syndrome | 21.48 | 10.21 | 35 | 189579 | 26455 | 56075998 |
Sarcoidosis | 21.36 | 10.21 | 53 | 189561 | 5427 | 56097026 |
Lower respiratory tract congestion | 21.24 | 10.21 | 33 | 189581 | 2393 | 56100060 |
Product container issue | 21.18 | 10.21 | 26 | 189588 | 1508 | 56100945 |
Airway remodelling | 21.13 | 10.21 | 8 | 189606 | 56 | 56102397 |
Choking sensation | 20.98 | 10.21 | 39 | 189575 | 3272 | 56099181 |
Upper airway obstruction | 20.95 | 10.21 | 17 | 189597 | 594 | 56101859 |
Nasal inflammation | 20.93 | 10.21 | 15 | 189599 | 434 | 56102019 |
Body temperature decreased | 20.87 | 10.21 | 118 | 189496 | 17990 | 56084463 |
Anaphylactic shock | 20.82 | 10.21 | 135 | 189479 | 21605 | 56080848 |
Educational problem | 20.81 | 10.21 | 14 | 189600 | 365 | 56102088 |
Muscle spasticity | 20.66 | 10.21 | 22 | 189592 | 19938 | 56082515 |
Exposure to allergen | 20.64 | 10.21 | 12 | 189602 | 240 | 56102213 |
Expiratory reserve volume decreased | 20.62 | 10.21 | 7 | 189607 | 34 | 56102419 |
Lung disorder | 20.53 | 10.21 | 269 | 189345 | 52328 | 56050125 |
Eye paraesthesia | 20.40 | 10.21 | 9 | 189605 | 97 | 56102356 |
Weight decreased | 20.21 | 10.21 | 998 | 188616 | 239716 | 55862737 |
Cardiac murmur | 20.15 | 10.21 | 84 | 189530 | 11317 | 56091136 |
Paraesthesia oral | 19.97 | 10.21 | 99 | 189515 | 14350 | 56088103 |
Hysterectomy | 19.90 | 10.21 | 69 | 189545 | 8522 | 56093931 |
Appetite disorder | 19.89 | 10.21 | 58 | 189556 | 6535 | 56095918 |
Myalgia | 19.89 | 10.21 | 584 | 189030 | 131441 | 55971012 |
Metastases to central nervous system | 19.83 | 10.21 | 8 | 189606 | 12128 | 56090325 |
CFTR gene mutation | 19.77 | 10.21 | 9 | 189605 | 105 | 56102348 |
Eosinophilic oesophagitis | 19.58 | 10.21 | 12 | 189602 | 265 | 56102188 |
Sinus operation | 19.54 | 10.21 | 29 | 189585 | 2019 | 56100434 |
Inappropriate antidiuretic hormone secretion | 19.52 | 10.21 | 11 | 189603 | 13745 | 56088708 |
Blood pressure fluctuation | 19.50 | 10.21 | 70 | 189544 | 40290 | 56062163 |
Dyspnoea at rest | 19.44 | 10.21 | 41 | 189573 | 3772 | 56098681 |
Weight increased | 19.41 | 10.21 | 953 | 188661 | 228750 | 55873703 |
Sedation | 19.23 | 10.21 | 57 | 189557 | 34797 | 56067656 |
Injection site movement impairment | 19.23 | 10.21 | 6 | 189608 | 21 | 56102432 |
Tenosynovitis | 19.12 | 10.21 | 9 | 189605 | 12452 | 56090001 |
Drug eruption | 19.11 | 10.21 | 36 | 189578 | 25727 | 56076726 |
Conjunctivitis allergic | 19.11 | 10.21 | 18 | 189596 | 770 | 56101683 |
Colitis ulcerative | 19.06 | 10.21 | 33 | 189581 | 24358 | 56078095 |
Torsade de pointes | 19.06 | 10.21 | 9 | 189605 | 12431 | 56090022 |
Pleural effusion | 18.97 | 10.21 | 190 | 189424 | 85290 | 56017163 |
Thinking abnormal | 18.97 | 10.21 | 75 | 189539 | 9866 | 56092587 |
Cerebral infarction | 18.95 | 10.21 | 29 | 189585 | 22476 | 56079977 |
Cognitive disorder | 18.91 | 10.21 | 93 | 189521 | 49040 | 56053413 |
Adrenal suppression | 18.90 | 10.21 | 19 | 189595 | 881 | 56101572 |
Airway peak pressure increased | 18.89 | 10.21 | 12 | 189602 | 283 | 56102170 |
Gluten sensitivity | 18.81 | 10.21 | 15 | 189599 | 511 | 56101942 |
Atrial fibrillation | 18.77 | 10.21 | 256 | 189358 | 108641 | 55993812 |
Panniculitis | 18.70 | 10.21 | 5 | 189609 | 9837 | 56092616 |
Obstruction | 18.68 | 10.21 | 31 | 189583 | 2377 | 56100076 |
Depressed mood | 18.65 | 10.21 | 196 | 189418 | 36163 | 56066290 |
Sleep disorder | 18.62 | 10.21 | 326 | 189288 | 67337 | 56035116 |
Tuberculosis | 18.47 | 10.21 | 7 | 189607 | 11022 | 56091431 |
Mycotic allergy | 18.39 | 10.21 | 18 | 189596 | 808 | 56101645 |
Stevens-Johnson syndrome | 18.32 | 10.21 | 30 | 189584 | 22633 | 56079820 |
Paranoia | 18.09 | 10.21 | 78 | 189536 | 10666 | 56091787 |
Joint stiffness | 18.08 | 10.21 | 60 | 189554 | 35365 | 56067088 |
Hypoglycaemia | 18.01 | 10.21 | 112 | 189502 | 55703 | 56046750 |
Drug resistance | 17.75 | 10.21 | 26 | 189588 | 20516 | 56081937 |
Nervousness | 17.61 | 10.21 | 162 | 189452 | 28853 | 56073600 |
Bacteraemia | 17.60 | 10.21 | 16 | 189598 | 15615 | 56086838 |
Lactose intolerance | 17.59 | 10.21 | 32 | 189582 | 2640 | 56099813 |
Sinus polyp | 17.53 | 10.21 | 12 | 189602 | 322 | 56102131 |
Pregnancy | 17.52 | 10.21 | 55 | 189559 | 32978 | 56069475 |
Acute hepatic failure | 17.47 | 10.21 | 18 | 189596 | 16560 | 56085893 |
Foetal exposure during pregnancy | 17.46 | 10.21 | 57 | 189557 | 33766 | 56068687 |
Acute sinusitis | 17.44 | 10.21 | 38 | 189576 | 3575 | 56098878 |
Skin necrosis | 17.38 | 10.21 | 10 | 189604 | 12351 | 56090102 |
Injection site scab | 17.36 | 10.21 | 13 | 189601 | 403 | 56102050 |
Allergic sinusitis | 17.33 | 10.21 | 16 | 189598 | 667 | 56101786 |
Hypoalbuminaemia | 17.30 | 10.21 | 7 | 189607 | 10592 | 56091861 |
Pulmonary thrombosis | 17.29 | 10.21 | 63 | 189551 | 7974 | 56094479 |
Oropharyngeal discomfort | 17.19 | 10.21 | 43 | 189571 | 4425 | 56098028 |
Oesophageal dilatation | 17.09 | 10.21 | 12 | 189602 | 336 | 56102117 |
Ill-defined disorder | 17.09 | 10.21 | 148 | 189466 | 68395 | 56034058 |
Pneumococcal infection | 17.06 | 10.21 | 13 | 189601 | 414 | 56102039 |
Foot deformity | 17.06 | 10.21 | 34 | 189580 | 23791 | 56078662 |
Ulcer | 17.05 | 10.21 | 31 | 189583 | 22454 | 56079999 |
Pulmonary toxicity | 17.01 | 10.21 | 3 | 189611 | 7880 | 56094573 |
Administration site erythema | 16.98 | 10.21 | 15 | 189599 | 590 | 56101863 |
Cortisol decreased | 16.96 | 10.21 | 20 | 189594 | 1112 | 56101341 |
Ischaemic stroke | 16.95 | 10.21 | 19 | 189595 | 16823 | 56085630 |
Nephropathy toxic | 16.84 | 10.21 | 4 | 189610 | 8523 | 56093930 |
Pre-existing condition improved | 16.77 | 10.21 | 59 | 189555 | 7339 | 56095114 |
Hypercalcaemia | 16.74 | 10.21 | 38 | 189576 | 25373 | 56077080 |
Respiratory tract irritation | 16.66 | 10.21 | 13 | 189601 | 429 | 56102024 |
Cytopenia | 16.66 | 10.21 | 6 | 189608 | 9749 | 56092704 |
Blood alkaline phosphatase increased | 16.60 | 10.21 | 71 | 189543 | 38874 | 56063579 |
Night sweats | 16.45 | 10.21 | 77 | 189537 | 41136 | 56061317 |
Hiatus hernia | 16.42 | 10.21 | 118 | 189496 | 19534 | 56082919 |
Epilepsy | 16.41 | 10.21 | 38 | 189576 | 25193 | 56077260 |
Drug reaction with eosinophilia and systemic symptoms | 16.40 | 10.21 | 50 | 189564 | 30254 | 56072199 |
Bronchial irritation | 16.36 | 10.21 | 5 | 189609 | 16 | 56102437 |
Intentional product misuse | 16.28 | 10.21 | 104 | 189510 | 51400 | 56051053 |
Blood immunoglobulin E decreased | 16.24 | 10.21 | 7 | 189607 | 71 | 56102382 |
Exposure during pregnancy | 16.18 | 10.21 | 343 | 189271 | 135999 | 55966454 |
Oxygen consumption decreased | 16.08 | 10.21 | 10 | 189604 | 227 | 56102226 |
Bronchial wall thickening | 16.05 | 10.21 | 19 | 189595 | 1061 | 56101392 |
Prescribed underdose | 16.02 | 10.21 | 28 | 189586 | 20589 | 56081864 |
Myelodysplastic syndrome | 15.98 | 10.21 | 19 | 189595 | 16387 | 56086066 |
Nodular vasculitis | 15.91 | 10.21 | 5 | 189609 | 18 | 56102435 |
Neurogenic shock | 15.79 | 10.21 | 11 | 189603 | 304 | 56102149 |
Vocal cord disorder | 15.76 | 10.21 | 21 | 189593 | 1322 | 56101131 |
Liver function test abnormal | 15.60 | 10.21 | 90 | 189524 | 45581 | 56056872 |
Product contamination physical | 15.58 | 10.21 | 7 | 189607 | 79 | 56102374 |
Peritonitis | 15.53 | 10.21 | 19 | 189595 | 16183 | 56086270 |
Pneumocystis jirovecii pneumonia | 15.49 | 10.21 | 18 | 189596 | 15683 | 56086770 |
Candida infection | 15.42 | 10.21 | 143 | 189471 | 25524 | 56076929 |
Eye swelling | 15.41 | 10.21 | 124 | 189490 | 21252 | 56081201 |
Sinus headache | 15.33 | 10.21 | 44 | 189570 | 4914 | 56097539 |
Muscle tension dysphonia | 15.21 | 10.21 | 7 | 189607 | 84 | 56102369 |
Acute myocardial infarction | 15.16 | 10.21 | 52 | 189562 | 30341 | 56072112 |
Fungal infection | 15.15 | 10.21 | 174 | 189440 | 32819 | 56069634 |
Tic | 15.11 | 10.21 | 20 | 189594 | 1251 | 56101202 |
Decubitus ulcer | 15.09 | 10.21 | 7 | 189607 | 9768 | 56092685 |
Miller Fisher syndrome | 14.92 | 10.21 | 7 | 189607 | 88 | 56102365 |
Osteomyelitis | 14.78 | 10.21 | 38 | 189576 | 24308 | 56078145 |
Rhinitis perennial | 14.78 | 10.21 | 5 | 189609 | 24 | 56102429 |
Laryngitis fungal | 14.75 | 10.21 | 8 | 189606 | 139 | 56102314 |
Ligament sprain | 14.72 | 10.21 | 77 | 189537 | 11398 | 56091055 |
Lymphopenia | 14.72 | 10.21 | 21 | 189593 | 16753 | 56085700 |
Altered state of consciousness | 14.71 | 10.21 | 35 | 189579 | 22986 | 56079467 |
Depressive symptom | 14.61 | 10.21 | 35 | 189579 | 3506 | 56098947 |
Blood parathyroid hormone decreased | 14.53 | 10.21 | 5 | 189609 | 8359 | 56094094 |
Blood calcium decreased | 14.51 | 10.21 | 37 | 189577 | 23732 | 56078721 |
Gallbladder disorder | 14.43 | 10.21 | 104 | 189510 | 17230 | 56085223 |
Metastases to lung | 14.42 | 10.21 | 11 | 189603 | 11707 | 56090746 |
Hypothyroidism | 14.35 | 10.21 | 194 | 189420 | 38002 | 56064451 |
Upper limb fracture | 14.32 | 10.21 | 103 | 189511 | 17052 | 56085401 |
Pulmonary embolism | 14.31 | 10.21 | 467 | 189147 | 106657 | 55995796 |
Injection site pain | 14.24 | 10.21 | 505 | 189109 | 116613 | 55985840 |
Product packaging confusion | 14.12 | 10.21 | 8 | 189606 | 152 | 56102301 |
Premature baby | 14.10 | 10.21 | 27 | 189587 | 19178 | 56083275 |
Defiant behaviour | 14.09 | 10.21 | 3 | 189611 | 0 | 56102453 |
Pulmonary function challenge test abnormal | 14.09 | 10.21 | 3 | 189611 | 0 | 56102453 |
Sleep study abnormal | 14.09 | 10.21 | 3 | 189611 | 0 | 56102453 |
Glomus tumour | 14.09 | 10.21 | 3 | 189611 | 0 | 56102453 |
Lip discolouration | 14.08 | 10.21 | 13 | 189601 | 542 | 56101911 |
Diverticulum | 14.02 | 10.21 | 74 | 189540 | 10992 | 56091461 |
Ear swelling | 14.01 | 10.21 | 19 | 189595 | 1217 | 56101236 |
Electrocardiogram QT prolonged | 13.99 | 10.21 | 117 | 189497 | 54471 | 56047982 |
Accidental overdose | 13.97 | 10.21 | 30 | 189584 | 20431 | 56082022 |
Fracture pain | 13.89 | 10.21 | 11 | 189603 | 371 | 56102082 |
Acute generalised exanthematous pustulosis | 13.85 | 10.21 | 8 | 189606 | 9861 | 56092592 |
Transaminases increased | 13.83 | 10.21 | 50 | 189564 | 28720 | 56073733 |
Anticholinergic syndrome | 13.81 | 10.21 | 24 | 189590 | 1910 | 56100543 |
Otorrhoea | 13.76 | 10.21 | 20 | 189594 | 1367 | 56101086 |
Melaena | 13.71 | 10.21 | 49 | 189565 | 28241 | 56074212 |
Squamous cell carcinoma of the oral cavity | 13.70 | 10.21 | 10 | 189604 | 298 | 56102155 |
Respiratory tract infection viral | 13.66 | 10.21 | 24 | 189590 | 1927 | 56100526 |
Cytokine release syndrome | 13.65 | 10.21 | 10 | 189604 | 10865 | 56091588 |
Distal intestinal obstruction syndrome | 13.64 | 10.21 | 11 | 189603 | 381 | 56102072 |
Mucosal discolouration | 13.61 | 10.21 | 12 | 189602 | 471 | 56101982 |
Facet joint syndrome | 13.57 | 10.21 | 3 | 189611 | 6714 | 56095739 |
Therapeutic response unexpected | 13.47 | 10.21 | 101 | 189513 | 16943 | 56085510 |
Diabetic ketoacidosis | 13.45 | 10.21 | 27 | 189587 | 18844 | 56083609 |
Unresponsive to stimuli | 13.43 | 10.21 | 58 | 189556 | 31667 | 56070786 |
PCO2 increased | 13.31 | 10.21 | 18 | 189596 | 1150 | 56101303 |
Forced expiratory volume | 13.28 | 10.21 | 4 | 189610 | 12 | 56102441 |
Lung diffusion disorder | 13.26 | 10.21 | 6 | 189608 | 69 | 56102384 |
Temperature intolerance | 13.26 | 10.21 | 58 | 189556 | 7982 | 56094471 |
Emotional distress | 13.24 | 10.21 | 156 | 189458 | 29607 | 56072846 |
Dysphemia | 13.18 | 10.21 | 27 | 189587 | 2433 | 56100020 |
Sputum retention | 13.17 | 10.21 | 12 | 189602 | 492 | 56101961 |
Mandibular mass | 13.16 | 10.21 | 8 | 189606 | 174 | 56102279 |
Muscle rigidity | 13.15 | 10.21 | 10 | 189604 | 10661 | 56091792 |
Functional residual capacity increased | 13.11 | 10.21 | 6 | 189608 | 71 | 56102382 |
Haemophagocytic lymphohistiocytosis | 13.09 | 10.21 | 8 | 189606 | 9564 | 56092889 |
Vaccination site swelling | 13.08 | 10.21 | 5 | 189609 | 36 | 56102417 |
Hepatic encephalopathy | 13.08 | 10.21 | 9 | 189605 | 10101 | 56092352 |
Body temperature abnormal | 13.08 | 10.21 | 21 | 189593 | 1566 | 56100887 |
Female genital tract fistula | 13.06 | 10.21 | 39 | 189575 | 4453 | 56098000 |
Hospitalisation | 13.05 | 10.21 | 338 | 189276 | 74662 | 56027791 |
Frequent bowel movements | 13.04 | 10.21 | 22 | 189592 | 16402 | 56086051 |
Posterior reversible encephalopathy syndrome | 13.02 | 10.21 | 21 | 189593 | 15939 | 56086514 |
Injection site hypoaesthesia | 13.02 | 10.21 | 11 | 189603 | 407 | 56102046 |
Oesophagogastroduodenoscopy | 12.99 | 10.21 | 7 | 189607 | 120 | 56102333 |
Left ventricular dysfunction | 12.99 | 10.21 | 11 | 189603 | 11112 | 56091341 |
Forced expiratory volume abnormal | 12.96 | 10.21 | 6 | 189608 | 73 | 56102380 |
Sinus bradycardia | 12.95 | 10.21 | 16 | 189598 | 13570 | 56088883 |
Product taste abnormal | 12.93 | 10.21 | 23 | 189591 | 1865 | 56100588 |
Uveitis | 12.92 | 10.21 | 11 | 189603 | 11084 | 56091369 |
Overdose | 12.92 | 10.21 | 265 | 189349 | 105565 | 55996888 |
Cold agglutinins positive | 12.85 | 10.21 | 5 | 189609 | 38 | 56102415 |
Female reproductive neoplasm | 12.85 | 10.21 | 5 | 189609 | 38 | 56102415 |
Musculoskeletal pain | 12.85 | 10.21 | 194 | 189420 | 80958 | 56021495 |
Flushing | 12.81 | 10.21 | 318 | 189296 | 69782 | 56032671 |
Diastolic dysfunction | 12.78 | 10.21 | 45 | 189569 | 5600 | 56096853 |
Schizophrenia | 12.74 | 10.21 | 10 | 189604 | 10489 | 56091964 |
Speech disorder | 12.70 | 10.21 | 187 | 189427 | 37306 | 56065147 |
Proteinuria | 12.64 | 10.21 | 25 | 189589 | 17545 | 56084908 |
Product appearance confusion | 12.63 | 10.21 | 5 | 189609 | 40 | 56102413 |
Hypothermia | 12.62 | 10.21 | 14 | 189600 | 12456 | 56089997 |
Laryngeal oedema | 12.61 | 10.21 | 43 | 189571 | 5267 | 56097186 |
Eczema impetiginous | 12.61 | 10.21 | 4 | 189610 | 15 | 56102438 |
Hypersensitivity | 12.60 | 10.21 | 1015 | 188599 | 255393 | 55847060 |
Female sterilisation | 12.55 | 10.21 | 12 | 189602 | 523 | 56101930 |
Administration site swelling | 12.54 | 10.21 | 17 | 189597 | 1088 | 56101365 |
Functional residual capacity decreased | 12.54 | 10.21 | 6 | 189608 | 79 | 56102374 |
Forced expiratory flow decreased | 12.54 | 10.21 | 6 | 189608 | 79 | 56102374 |
Diffuse large B-cell lymphoma | 12.53 | 10.21 | 4 | 189610 | 7012 | 56095441 |
Oropharyngitis fungal | 12.53 | 10.21 | 5 | 189609 | 41 | 56102412 |
Inhalation therapy | 12.53 | 10.21 | 5 | 189609 | 41 | 56102412 |
Neuropsychiatric syndrome | 12.53 | 10.21 | 5 | 189609 | 41 | 56102412 |
Pulmonary eosinophilia | 12.51 | 10.21 | 9 | 189605 | 262 | 56102191 |
Middle ear effusion | 12.48 | 10.21 | 25 | 189589 | 2217 | 56100236 |
Product dispensing error | 12.47 | 10.21 | 63 | 189551 | 9201 | 56093252 |
Abnormal weight gain | 12.42 | 10.21 | 20 | 189594 | 1495 | 56100958 |
Skin lesion | 12.31 | 10.21 | 147 | 189467 | 27988 | 56074465 |
Product availability issue | 12.30 | 10.21 | 30 | 189584 | 3039 | 56099414 |
Snoring | 12.28 | 10.21 | 33 | 189581 | 3548 | 56098905 |
Systemic mastocytosis | 12.25 | 10.21 | 8 | 189606 | 198 | 56102255 |
Low birth weight baby | 12.23 | 10.21 | 3 | 189611 | 6255 | 56096198 |
Infusion site nodule | 12.23 | 10.21 | 18 | 189596 | 1244 | 56101209 |
Hypereosinophilic syndrome | 12.22 | 10.21 | 9 | 189605 | 272 | 56102181 |
Hallucination | 12.19 | 10.21 | 233 | 189381 | 48916 | 56053537 |
Administration site pruritus | 12.19 | 10.21 | 9 | 189605 | 273 | 56102180 |
Breast cancer stage I | 12.15 | 10.21 | 3 | 189611 | 6227 | 56096226 |
Jaundice | 12.11 | 10.21 | 49 | 189565 | 27245 | 56075208 |
Polymorphic eruption of pregnancy | 12.02 | 10.21 | 3 | 189611 | 3 | 56102450 |
Platelet adhesiveness decreased | 12.02 | 10.21 | 3 | 189611 | 3 | 56102450 |
Basal cell carcinoma | 12.01 | 10.21 | 44 | 189570 | 25177 | 56077276 |
Plasma cell myeloma | 11.95 | 10.21 | 100 | 189514 | 46546 | 56055907 |
Cardiogenic shock | 11.94 | 10.21 | 23 | 189591 | 16302 | 56086151 |
Cephalo-pelvic disproportion | 11.94 | 10.21 | 8 | 189606 | 207 | 56102246 |
Stress urinary incontinence | 11.94 | 10.21 | 24 | 189590 | 2134 | 56100319 |
Exposure to fungus | 11.91 | 10.21 | 7 | 189607 | 143 | 56102310 |
SARS-CoV-2 test positive | 11.89 | 10.21 | 47 | 189567 | 6182 | 56096271 |
Diverticulum oesophageal | 11.86 | 10.21 | 7 | 189607 | 144 | 56102309 |
Laryngeal stenosis | 11.85 | 10.21 | 15 | 189599 | 898 | 56101555 |
Malnutrition | 11.84 | 10.21 | 18 | 189596 | 13990 | 56088463 |
Atrioventricular block first degree | 11.83 | 10.21 | 4 | 189610 | 6761 | 56095692 |
Renal disorder | 11.80 | 10.21 | 152 | 189462 | 29453 | 56073000 |
Neoplasm malignant | 11.73 | 10.21 | 49 | 189565 | 27006 | 56075447 |
Pneumonia respiratory syncytial viral | 11.67 | 10.21 | 13 | 189601 | 679 | 56101774 |
Self-injurious ideation | 11.67 | 10.21 | 25 | 189589 | 2325 | 56100128 |
Painful respiration | 11.64 | 10.21 | 26 | 189588 | 2488 | 56099965 |
Fear | 11.59 | 10.21 | 88 | 189526 | 14820 | 56087633 |
Clostridium difficile colitis | 11.57 | 10.21 | 29 | 189585 | 18709 | 56083744 |
Coagulopathy | 11.53 | 10.21 | 29 | 189585 | 18687 | 56083766 |
Device expulsion | 11.51 | 10.21 | 58 | 189556 | 30391 | 56072062 |
Hyperplastic cholecystopathy | 11.50 | 10.21 | 6 | 189608 | 96 | 56102357 |
Aplastic anaemia | 11.48 | 10.21 | 8 | 189606 | 8920 | 56093533 |
Animal scratch | 11.48 | 10.21 | 16 | 189598 | 1052 | 56101401 |
International normalised ratio increased | 11.47 | 10.21 | 94 | 189520 | 43947 | 56058506 |
Mycobacterium avium complex infection | 11.45 | 10.21 | 28 | 189586 | 2841 | 56099612 |
Poisoning deliberate | 11.43 | 10.21 | 10 | 189604 | 9943 | 56092510 |
Dyslipidaemia | 11.38 | 10.21 | 47 | 189567 | 6306 | 56096147 |
Miosis | 11.35 | 10.21 | 4 | 189610 | 6588 | 56095865 |
Screaming | 11.34 | 10.21 | 29 | 189585 | 3025 | 56099428 |
Phlebectomy | 11.33 | 10.21 | 5 | 189609 | 54 | 56102399 |
Ejection fraction decreased | 11.27 | 10.21 | 32 | 189582 | 19809 | 56082644 |
Blood lactate dehydrogenase increased | 11.27 | 10.21 | 34 | 189580 | 20641 | 56081812 |
Pulmonary renal syndrome | 11.24 | 10.21 | 10 | 189604 | 397 | 56102056 |
Infusion site warmth | 11.22 | 10.21 | 19 | 189595 | 1481 | 56100972 |
Respiratory arrest | 11.20 | 10.21 | 59 | 189555 | 30566 | 56071887 |
Hyperventilation | 11.09 | 10.21 | 43 | 189571 | 5605 | 56096848 |
Cerebral haemorrhage | 11.09 | 10.21 | 54 | 189560 | 28552 | 56073901 |
Sputum culture | 11.06 | 10.21 | 7 | 189607 | 164 | 56102289 |
Back pain | 11.04 | 10.21 | 935 | 188679 | 236235 | 55866218 |
Oral pruritus | 11.04 | 10.21 | 21 | 189593 | 1793 | 56100660 |
Neuropathy peripheral | 11.02 | 10.21 | 263 | 189351 | 102630 | 55999823 |
Glossitis | 11.02 | 10.21 | 27 | 189587 | 2743 | 56099710 |
Obsessive thoughts | 10.96 | 10.21 | 11 | 189603 | 509 | 56101944 |
Hypertensive crisis | 10.96 | 10.21 | 19 | 189595 | 14017 | 56088436 |
Face injury | 10.95 | 10.21 | 28 | 189586 | 2921 | 56099532 |
Dizziness | 10.88 | 10.21 | 1436 | 188178 | 374704 | 55727749 |
Hepatic cirrhosis | 10.86 | 10.21 | 36 | 189578 | 21227 | 56081226 |
Hearing aid user | 10.86 | 10.21 | 5 | 189609 | 60 | 56102393 |
Overweight | 10.82 | 10.21 | 30 | 189584 | 3284 | 56099169 |
Peak expiratory flow rate increased | 10.81 | 10.21 | 3 | 189611 | 6 | 56102447 |
Vaccination complication | 10.79 | 10.21 | 15 | 189599 | 984 | 56101469 |
Serum sickness | 10.78 | 10.21 | 26 | 189588 | 2616 | 56099837 |
PO2 decreased | 10.70 | 10.21 | 18 | 189596 | 1395 | 56101058 |
Femur fracture | 10.63 | 10.21 | 83 | 189531 | 39212 | 56063241 |
Unintentional medical device removal | 10.62 | 10.21 | 3 | 189611 | 5691 | 56096762 |
Blood immunoglobulin G decreased | 10.56 | 10.21 | 23 | 189591 | 2163 | 56100290 |
Abdominal pain lower | 10.53 | 10.21 | 41 | 189573 | 23051 | 56079402 |
Prothrombin time prolonged | 10.53 | 10.21 | 9 | 189605 | 9051 | 56093402 |
Congenital naevus | 10.52 | 10.21 | 7 | 189607 | 179 | 56102274 |
Status epilepticus | 10.51 | 10.21 | 22 | 189592 | 15119 | 56087334 |
School refusal | 10.50 | 10.21 | 3 | 189611 | 7 | 56102446 |
Mouth swelling | 10.46 | 10.21 | 34 | 189580 | 4063 | 56098390 |
Pertussis | 10.41 | 10.21 | 12 | 189602 | 651 | 56101802 |
Vaccination site pain | 10.41 | 10.21 | 6 | 189608 | 118 | 56102335 |
COVID-19 immunisation | 10.39 | 10.21 | 18 | 189596 | 1429 | 56101024 |
Mechanical urticaria | 10.36 | 10.21 | 10 | 189604 | 441 | 56102012 |
Intestinal perforation | 10.35 | 10.21 | 13 | 189601 | 10946 | 56091507 |
Urinary retention | 10.31 | 10.21 | 54 | 189560 | 28020 | 56074433 |
Breast cancer female | 10.29 | 10.21 | 16 | 189598 | 12322 | 56090131 |
Oliguria | 10.29 | 10.21 | 8 | 189606 | 8432 | 56094021 |
Skin sensitisation | 10.23 | 10.21 | 13 | 189601 | 781 | 56101672 |
Alice in wonderland syndrome | 10.22 | 10.21 | 4 | 189610 | 31 | 56102422 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Asthma | 3769.19 | 11.17 | 1900 | 74440 | 40711 | 31580293 |
Wheezing | 1299.64 | 11.17 | 901 | 75439 | 35085 | 31585919 |
Eosinophilic granulomatosis with polyangiitis | 847.02 | 11.17 | 263 | 76077 | 1368 | 31619636 |
Obstructive airways disorder | 736.70 | 11.17 | 429 | 75911 | 12235 | 31608769 |
Cough | 499.92 | 11.17 | 1041 | 75299 | 133773 | 31487231 |
Full blood count abnormal | 483.42 | 11.17 | 363 | 75977 | 15984 | 31605020 |
Forced expiratory volume decreased | 433.50 | 11.17 | 188 | 76152 | 2789 | 31618215 |
Sleep terror | 409.62 | 11.17 | 126 | 76214 | 631 | 31620373 |
Productive cough | 378.99 | 11.17 | 435 | 75905 | 33105 | 31587899 |
Dyspnoea | 359.73 | 11.17 | 1704 | 74636 | 341775 | 31279229 |
Abnormal behaviour | 344.42 | 11.17 | 352 | 75988 | 23476 | 31597528 |
Suicidal ideation | 342.19 | 11.17 | 430 | 75910 | 35976 | 31585028 |
Sleep disorder due to a general medical condition | 303.10 | 11.17 | 160 | 76180 | 3742 | 31617262 |
Therapeutic product effect incomplete | 293.98 | 11.17 | 439 | 75901 | 43257 | 31577747 |
Aggression | 277.52 | 11.17 | 393 | 75947 | 36898 | 31584106 |
Nightmare | 276.02 | 11.17 | 231 | 76109 | 11906 | 31609098 |
Toxicity to various agents | 271.14 | 11.17 | 54 | 76286 | 181433 | 31439571 |
Nasal congestion | 239.72 | 11.17 | 270 | 76070 | 20111 | 31600893 |
Chest discomfort | 237.16 | 11.17 | 426 | 75914 | 48943 | 31572061 |
Anger | 236.67 | 11.17 | 204 | 76136 | 10949 | 31610055 |
Sputum discoloured | 235.53 | 11.17 | 166 | 76174 | 6610 | 31614394 |
Middle insomnia | 229.78 | 11.17 | 157 | 76183 | 5942 | 31615062 |
Sinusitis | 223.30 | 11.17 | 352 | 75988 | 36344 | 31584660 |
Blood immunoglobulin E increased | 209.59 | 11.17 | 104 | 76236 | 2127 | 31618877 |
Acute kidney injury | 186.17 | 11.17 | 241 | 76099 | 279473 | 31341531 |
Nasal polyps | 180.73 | 11.17 | 91 | 76249 | 1922 | 31619082 |
Loss of personal independence in daily activities | 178.54 | 11.17 | 276 | 76064 | 28012 | 31592992 |
Anaemia | 169.44 | 11.17 | 159 | 76181 | 213363 | 31407641 |
Anxiety | 158.59 | 11.17 | 531 | 75809 | 90502 | 31530502 |
Depression | 144.47 | 11.17 | 514 | 75826 | 90301 | 31530703 |
Pulmonary function test decreased | 137.67 | 11.17 | 101 | 76239 | 4284 | 31616720 |
Mood altered | 134.73 | 11.17 | 131 | 76209 | 8215 | 31612789 |
Bronchial wall thickening | 128.96 | 11.17 | 61 | 76279 | 1118 | 31619886 |
Bronchiectasis | 128.07 | 11.17 | 122 | 76218 | 7458 | 31613546 |
Chronic obstructive pulmonary disease | 125.80 | 11.17 | 312 | 76028 | 44854 | 31576150 |
Death | 123.06 | 11.17 | 451 | 75889 | 360118 | 31260886 |
Infective pulmonary exacerbation of cystic fibrosis | 120.41 | 11.17 | 110 | 76230 | 6374 | 31614630 |
Crying | 119.99 | 11.17 | 103 | 76237 | 5494 | 31615510 |
Urticaria | 118.86 | 11.17 | 356 | 75984 | 57161 | 31563843 |
Gastrooesophageal reflux disease | 118.55 | 11.17 | 256 | 76084 | 33615 | 31587389 |
Thrombocytopenia | 117.03 | 11.17 | 103 | 76237 | 142644 | 31478360 |
Drug interaction | 115.95 | 11.17 | 203 | 76137 | 208340 | 31412664 |
Eosinophilia | 110.72 | 11.17 | 200 | 76140 | 23053 | 31597951 |
Rhinorrhoea | 107.13 | 11.17 | 196 | 76144 | 22816 | 31598188 |
Febrile neutropenia | 105.93 | 11.17 | 83 | 76257 | 121766 | 31499238 |
Bronchial secretion retention | 105.78 | 11.17 | 55 | 76285 | 1245 | 31619759 |
Pulmonary function test abnormal | 105.21 | 11.17 | 66 | 76274 | 2155 | 31618849 |
Nasopharyngitis | 102.25 | 11.17 | 360 | 75980 | 62885 | 31558119 |
Eosinophil count increased | 101.59 | 11.17 | 109 | 76231 | 7682 | 31613322 |
Off label use | 96.38 | 11.17 | 470 | 75870 | 346804 | 31274200 |
Asthmatic crisis | 95.96 | 11.17 | 38 | 76302 | 441 | 31620563 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 94.72 | 11.17 | 46 | 76294 | 896 | 31620108 |
Seasonal allergy | 94.52 | 11.17 | 90 | 76250 | 5498 | 31615506 |
Sleep disorder | 93.17 | 11.17 | 200 | 76140 | 26148 | 31594856 |
Rhinitis | 92.26 | 11.17 | 85 | 76255 | 4979 | 31616025 |
Bronchitis | 91.95 | 11.17 | 252 | 76088 | 38465 | 31582539 |
Impaired quality of life | 90.60 | 11.17 | 72 | 76268 | 3444 | 31617560 |
Hypotension | 88.76 | 11.17 | 229 | 76111 | 204389 | 31416615 |
Upper-airway cough syndrome | 86.99 | 11.17 | 67 | 76273 | 3060 | 31617944 |
Bronchial hyperreactivity | 86.74 | 11.17 | 50 | 76290 | 1395 | 31619609 |
Influenza | 86.54 | 11.17 | 269 | 76071 | 44056 | 31576948 |
Right atrial hypertrophy | 86.09 | 11.17 | 38 | 76302 | 589 | 31620415 |
Bronchospasm | 84.52 | 11.17 | 112 | 76228 | 9860 | 31611144 |
Dyspnoea exertional | 81.73 | 11.17 | 242 | 76098 | 38595 | 31582409 |
Pancytopenia | 81.69 | 11.17 | 55 | 76285 | 87261 | 31533743 |
Sensitivity to weather change | 79.76 | 11.17 | 48 | 76292 | 1453 | 31619551 |
Malignant neoplasm progression | 79.09 | 11.17 | 46 | 76294 | 78952 | 31542052 |
Drug abuse | 78.51 | 11.17 | 58 | 76282 | 87700 | 31533304 |
Neutropenia | 78.49 | 11.17 | 136 | 76204 | 140228 | 31480776 |
Bronchial obstruction | 78.39 | 11.17 | 47 | 76293 | 1413 | 31619591 |
Irritability | 77.79 | 11.17 | 171 | 76169 | 22718 | 31598286 |
Multiple organ dysfunction syndrome | 76.82 | 11.17 | 34 | 76306 | 68169 | 31552835 |
Tic | 76.04 | 11.17 | 51 | 76289 | 1870 | 31619134 |
Vital capacity decreased | 75.85 | 11.17 | 30 | 76310 | 347 | 31620657 |
Blood creatinine increased | 75.73 | 11.17 | 62 | 76278 | 89016 | 31531988 |
Sepsis | 73.83 | 11.17 | 160 | 76180 | 151769 | 31469235 |
Photodermatosis | 73.50 | 11.17 | 32 | 76308 | 479 | 31620525 |
Hypersensitivity | 73.25 | 11.17 | 297 | 76043 | 55446 | 31565558 |
Dysplastic naevus | 71.94 | 11.17 | 31 | 76309 | 452 | 31620552 |
Mood swings | 71.75 | 11.17 | 89 | 76251 | 7335 | 31613669 |
Solar lentigo | 71.32 | 11.17 | 31 | 76309 | 462 | 31620542 |
Ear infection | 71.07 | 11.17 | 97 | 76243 | 8784 | 31612220 |
Eosinophilic pneumonia chronic | 70.28 | 11.17 | 26 | 76314 | 247 | 31620757 |
Hyponatraemia | 69.68 | 11.17 | 46 | 76294 | 73753 | 31547251 |
Obstruction | 68.95 | 11.17 | 50 | 76290 | 2082 | 31618922 |
Screaming | 68.41 | 11.17 | 42 | 76298 | 1319 | 31619685 |
Bronchopulmonary aspergillosis allergic | 67.38 | 11.17 | 32 | 76308 | 592 | 31620412 |
Lower respiratory tract infection | 67.24 | 11.17 | 184 | 76156 | 28053 | 31592951 |
Dermatitis atopic | 66.90 | 11.17 | 70 | 76270 | 4792 | 31616212 |
Psychomotor hyperactivity | 65.87 | 11.17 | 93 | 76247 | 8694 | 31612310 |
Allergy to animal | 64.81 | 11.17 | 25 | 76315 | 269 | 31620735 |
Sneezing | 64.56 | 11.17 | 68 | 76272 | 4691 | 31616313 |
Leukopenia | 63.29 | 11.17 | 30 | 76310 | 57798 | 31563206 |
Headache | 62.26 | 11.17 | 696 | 75644 | 182956 | 31438048 |
Breath sounds abnormal | 62.22 | 11.17 | 74 | 76266 | 5838 | 31615166 |
Eye pruritus | 61.28 | 11.17 | 68 | 76272 | 4977 | 31616027 |
Right ventricular hypertrophy | 60.78 | 11.17 | 38 | 76302 | 1233 | 31619771 |
Sleep apnoea syndrome | 59.76 | 11.17 | 136 | 76204 | 18489 | 31602515 |
Haemoglobin decreased | 59.53 | 11.17 | 113 | 76227 | 112562 | 31508442 |
Confusional state | 59.46 | 11.17 | 147 | 76193 | 133187 | 31487817 |
Vocal cord dysfunction | 59.13 | 11.17 | 20 | 76320 | 142 | 31620862 |
Multiple allergies | 58.79 | 11.17 | 48 | 76292 | 2387 | 31618617 |
Respiratory tract congestion | 58.17 | 11.17 | 69 | 76271 | 5428 | 31615576 |
Aspirin-exacerbated respiratory disease | 57.68 | 11.17 | 25 | 76315 | 370 | 31620634 |
Blood cholesterol | 57.66 | 11.17 | 21 | 76319 | 190 | 31620814 |
Renal failure | 57.34 | 11.17 | 133 | 76207 | 123197 | 31497807 |
Diarrhoea | 57.28 | 11.17 | 558 | 75782 | 351851 | 31269153 |
Depressed mood | 57.13 | 11.17 | 129 | 76211 | 17446 | 31603558 |
Upper respiratory tract infection | 56.89 | 11.17 | 178 | 76162 | 29244 | 31591760 |
Victim of child abuse | 55.93 | 11.17 | 32 | 76308 | 880 | 31620124 |
Social avoidant behaviour | 55.72 | 11.17 | 51 | 76289 | 2962 | 31618042 |
Completed suicide | 55.50 | 11.17 | 84 | 76256 | 91430 | 31529574 |
Rhinitis perennial | 55.33 | 11.17 | 23 | 76317 | 305 | 31620699 |
Insomnia | 54.44 | 11.17 | 403 | 75937 | 94433 | 31526571 |
Osteoporosis | 54.33 | 11.17 | 99 | 76241 | 11484 | 31609520 |
Sputum increased | 53.30 | 11.17 | 43 | 76297 | 2102 | 31618902 |
Rhabdomyolysis | 53.10 | 11.17 | 45 | 76295 | 63536 | 31557468 |
Product dose omission issue | 53.04 | 11.17 | 435 | 75905 | 105151 | 31515853 |
Heart rate increased | 52.38 | 11.17 | 217 | 76123 | 40893 | 31580111 |
Nasal disorder | 52.30 | 11.17 | 39 | 76301 | 1696 | 31619308 |
Illness | 52.28 | 11.17 | 86 | 76254 | 9191 | 31611813 |
Rheumatoid arthritis | 50.51 | 11.17 | 26 | 76314 | 47783 | 31573221 |
Educational problem | 49.99 | 11.17 | 25 | 76315 | 520 | 31620484 |
Dehydration | 49.51 | 11.17 | 136 | 76204 | 118975 | 31502029 |
Disease progression | 49.30 | 11.17 | 89 | 76251 | 90375 | 31530629 |
Septic shock | 49.18 | 11.17 | 52 | 76288 | 66106 | 31554898 |
Dyspnoea at rest | 48.87 | 11.17 | 51 | 76289 | 3480 | 31617524 |
Blood pressure increased | 47.76 | 11.17 | 342 | 75998 | 79291 | 31541713 |
Discomfort | 47.64 | 11.17 | 115 | 76225 | 16241 | 31604763 |
Anaphylactic reaction | 47.52 | 11.17 | 168 | 76172 | 29385 | 31591619 |
Renal impairment | 47.01 | 11.17 | 85 | 76255 | 86264 | 31534740 |
Suffocation feeling | 46.98 | 11.17 | 24 | 76316 | 523 | 31620481 |
Platelet count decreased | 46.72 | 11.17 | 125 | 76215 | 110310 | 31510694 |
Product quality issue | 46.63 | 11.17 | 113 | 76227 | 15998 | 31605006 |
Eye disorder | 45.49 | 11.17 | 77 | 76263 | 8425 | 31612579 |
Gastrointestinal haemorrhage | 45.17 | 11.17 | 81 | 76259 | 82468 | 31538536 |
Foetal exposure during pregnancy | 45.04 | 11.17 | 21 | 76319 | 40855 | 31580149 |
Obesity | 44.80 | 11.17 | 89 | 76251 | 11011 | 31609993 |
Blood pressure systolic increased | 44.49 | 11.17 | 125 | 76215 | 19345 | 31601659 |
Panic attack | 44.17 | 11.17 | 77 | 76263 | 8626 | 31612378 |
Chronic sinusitis | 44.04 | 11.17 | 36 | 76304 | 1793 | 31619211 |
Personality change | 43.98 | 11.17 | 56 | 76284 | 4739 | 31616265 |
Oropharyngeal pain | 43.14 | 11.17 | 170 | 76170 | 31313 | 31589691 |
Eosinophil count | 43.02 | 11.17 | 15 | 76325 | 118 | 31620886 |
Dust allergy | 42.50 | 11.17 | 23 | 76317 | 566 | 31620438 |
Pruritus | 42.18 | 11.17 | 474 | 75866 | 124693 | 31496311 |
Food allergy | 41.26 | 11.17 | 28 | 76312 | 1047 | 31619957 |
Forced vital capacity decreased | 40.99 | 11.17 | 24 | 76316 | 690 | 31620314 |
Rhinitis allergic | 40.90 | 11.17 | 42 | 76298 | 2812 | 31618192 |
Ascites | 40.86 | 11.17 | 24 | 76316 | 40989 | 31580015 |
Negative thoughts | 40.74 | 11.17 | 23 | 76317 | 616 | 31620388 |
Aortic valve stenosis | 40.61 | 11.17 | 39 | 76301 | 2407 | 31618597 |
Hypoventilation | 40.06 | 11.17 | 43 | 76297 | 3031 | 31617973 |
Respiratory disorder | 40.00 | 11.17 | 114 | 76226 | 17786 | 31603218 |
Eye swelling | 39.99 | 11.17 | 76 | 76264 | 9100 | 31611904 |
Anosmia | 39.60 | 11.17 | 36 | 76304 | 2072 | 31618932 |
Eczema | 39.25 | 11.17 | 103 | 76237 | 15314 | 31605690 |
Cardiac arrest | 39.04 | 11.17 | 99 | 76241 | 88963 | 31532041 |
Emotional disorder | 38.52 | 11.17 | 55 | 76285 | 5194 | 31615810 |
Bone marrow failure | 38.39 | 11.17 | 10 | 76330 | 27998 | 31593006 |
Hyperkalaemia | 38.10 | 11.17 | 60 | 76280 | 64291 | 31556713 |
Chest X-ray abnormal | 38.04 | 11.17 | 48 | 76292 | 4025 | 31616979 |
Body temperature decreased | 37.81 | 11.17 | 86 | 76254 | 11684 | 31609320 |
General physical health deterioration | 37.74 | 11.17 | 143 | 76197 | 113292 | 31507712 |
Restrictive pulmonary disease | 37.66 | 11.17 | 27 | 76313 | 1104 | 31619900 |
Nasal inflammation | 37.65 | 11.17 | 16 | 76324 | 225 | 31620779 |
Ocular discomfort | 37.04 | 11.17 | 33 | 76307 | 1850 | 31619154 |
Sinus congestion | 36.26 | 11.17 | 52 | 76288 | 4931 | 31616073 |
Peak expiratory flow rate decreased | 35.28 | 11.17 | 13 | 76327 | 122 | 31620882 |
Perfume sensitivity | 35.14 | 11.17 | 12 | 76328 | 88 | 31620916 |
Smoke sensitivity | 35.00 | 11.17 | 13 | 76327 | 125 | 31620879 |
Respiratory tract infection | 34.64 | 11.17 | 107 | 76233 | 17454 | 31603550 |
Myocardial infarction | 34.60 | 11.17 | 148 | 76192 | 113306 | 31507698 |
Cardio-respiratory arrest | 33.80 | 11.17 | 45 | 76295 | 51681 | 31569323 |
Intentional overdose | 33.69 | 11.17 | 30 | 76310 | 41359 | 31579645 |
Respiratory rate increased | 33.62 | 11.17 | 71 | 76269 | 9174 | 31611830 |
Coma | 33.29 | 11.17 | 30 | 76310 | 41120 | 31579884 |
Cardiac failure | 32.89 | 11.17 | 102 | 76238 | 85851 | 31535153 |
Nasal oedema | 32.88 | 11.17 | 16 | 76324 | 313 | 31620691 |
Drug resistance | 32.86 | 11.17 | 8 | 76332 | 23445 | 31597559 |
Hypokalaemia | 32.63 | 11.17 | 49 | 76291 | 53525 | 31567479 |
Product use in unapproved indication | 31.79 | 11.17 | 372 | 75968 | 98799 | 31522205 |
Morbid thoughts | 31.77 | 11.17 | 14 | 76326 | 216 | 31620788 |
Reversible airways obstruction | 31.56 | 11.17 | 16 | 76324 | 343 | 31620661 |
Pleural effusion | 31.52 | 11.17 | 85 | 76255 | 74835 | 31546169 |
Sputum purulent | 31.28 | 11.17 | 17 | 76323 | 422 | 31620582 |
Status asthmaticus | 31.03 | 11.17 | 15 | 76325 | 289 | 31620715 |
Acute myocardial infarction | 30.45 | 11.17 | 47 | 76293 | 50776 | 31570228 |
Lung hyperinflation | 29.85 | 11.17 | 21 | 76319 | 833 | 31620171 |
Throat clearing | 29.72 | 11.17 | 14 | 76326 | 254 | 31620750 |
Blood test abnormal | 29.45 | 11.17 | 53 | 76287 | 6088 | 31614916 |
Malaise | 29.29 | 11.17 | 569 | 75771 | 167942 | 31453062 |
Pneumonia | 29.23 | 11.17 | 1033 | 75307 | 334279 | 31286725 |
C-reactive protein increased | 29.14 | 11.17 | 45 | 76295 | 48605 | 31572399 |
Oesophageal polyp | 28.63 | 11.17 | 9 | 76331 | 49 | 31620955 |
Sinus polyp | 28.61 | 11.17 | 12 | 76328 | 163 | 31620841 |
Adjustment disorder | 28.49 | 11.17 | 23 | 76317 | 1125 | 31619879 |
Agranulocytosis | 28.34 | 11.17 | 8 | 76332 | 21239 | 31599765 |
Delirium | 28.13 | 11.17 | 35 | 76305 | 41386 | 31579618 |
International normalised ratio increased | 27.89 | 11.17 | 41 | 76299 | 45182 | 31575822 |
Eosinophilic bronchitis | 27.84 | 11.17 | 12 | 76328 | 175 | 31620829 |
Total lung capacity abnormal | 27.67 | 11.17 | 11 | 76329 | 129 | 31620875 |
Pleural thickening | 27.62 | 11.17 | 14 | 76326 | 300 | 31620704 |
Nausea | 27.47 | 11.17 | 550 | 75790 | 307397 | 31313607 |
Stress | 27.44 | 11.17 | 126 | 76214 | 24815 | 31596189 |
Neuroleptic malignant syndrome | 27.36 | 11.17 | 4 | 76336 | 16865 | 31604139 |
Sinus disorder | 27.26 | 11.17 | 52 | 76288 | 6243 | 31614761 |
Forced expiratory volume abnormal | 27.26 | 11.17 | 8 | 76332 | 33 | 31620971 |
Nasal discharge discolouration | 27.25 | 11.17 | 13 | 76327 | 243 | 31620761 |
Blebitis | 27.13 | 11.17 | 6 | 76334 | 4 | 31621000 |
Cardiogenic shock | 27.12 | 11.17 | 10 | 76330 | 22398 | 31598606 |
Attention deficit hyperactivity disorder | 26.87 | 11.17 | 31 | 76309 | 2367 | 31618637 |
Throat tightness | 26.85 | 11.17 | 58 | 76282 | 7611 | 31613393 |
Diastolic dysfunction | 26.81 | 11.17 | 47 | 76293 | 5288 | 31615716 |
Mucosal inflammation | 26.78 | 11.17 | 26 | 76314 | 34401 | 31586603 |
Epidural lipomatosis | 26.76 | 11.17 | 19 | 76321 | 765 | 31620239 |
Cytomegalovirus infection | 26.74 | 11.17 | 13 | 76327 | 24694 | 31596310 |
Bradycardia | 26.71 | 11.17 | 82 | 76258 | 69245 | 31551759 |
Intervertebral disc degeneration | 26.61 | 11.17 | 48 | 76292 | 5523 | 31615481 |
Endocarditis fibroplastica | 26.56 | 11.17 | 6 | 76334 | 5 | 31620999 |
Homicidal ideation | 26.56 | 11.17 | 32 | 76308 | 2559 | 31618445 |
Metabolic acidosis | 26.29 | 11.17 | 34 | 76306 | 39543 | 31581461 |
Hepatic failure | 26.26 | 11.17 | 24 | 76316 | 32678 | 31588326 |
Hypereosinophilic syndrome | 26.18 | 11.17 | 12 | 76328 | 204 | 31620800 |
Attention-seeking behaviour | 26.18 | 11.17 | 8 | 76332 | 39 | 31620965 |
Excessive eye blinking | 26.16 | 11.17 | 16 | 76324 | 499 | 31620505 |
Snoring | 26.04 | 11.17 | 34 | 76306 | 2949 | 31618055 |
Syncope | 26.03 | 11.17 | 111 | 76229 | 85071 | 31535933 |
Suicidal behaviour | 26.01 | 11.17 | 24 | 76316 | 1408 | 31619596 |
Electrocardiogram QT prolonged | 25.90 | 11.17 | 32 | 76308 | 37955 | 31583049 |
Haematemesis | 25.56 | 11.17 | 15 | 76325 | 25638 | 31595366 |
Throat irritation | 25.54 | 11.17 | 64 | 76276 | 9250 | 31611754 |
Cerebral haemorrhage | 25.27 | 11.17 | 25 | 76315 | 32787 | 31588217 |
Product substitution issue | 25.02 | 11.17 | 64 | 76276 | 9368 | 31611636 |
Panic reaction | 24.93 | 11.17 | 23 | 76317 | 1349 | 31619655 |
Cystic fibrosis | 24.74 | 11.17 | 27 | 76313 | 1939 | 31619065 |
Pigment dispersion syndrome | 24.71 | 11.17 | 6 | 76334 | 9 | 31620995 |
Sleep talking | 24.63 | 11.17 | 15 | 76325 | 464 | 31620540 |
Neoplasm progression | 24.62 | 11.17 | 9 | 76331 | 20263 | 31600741 |
Blood immunoglobulin G decreased | 24.39 | 11.17 | 22 | 76318 | 1253 | 31619751 |
Polyp | 24.39 | 11.17 | 35 | 76305 | 3321 | 31617683 |
Asthenia | 24.26 | 11.17 | 388 | 75952 | 224367 | 31396637 |
Enuresis | 24.08 | 11.17 | 28 | 76312 | 2156 | 31618848 |
Contraindicated product administered | 23.64 | 11.17 | 9 | 76331 | 19763 | 31601241 |
Blood lactic acid | 23.55 | 11.17 | 13 | 76327 | 333 | 31620671 |
Asthma exercise induced | 23.40 | 11.17 | 9 | 76331 | 96 | 31620908 |
Constipation | 23.25 | 11.17 | 189 | 76151 | 123802 | 31497202 |
Melaena | 22.80 | 11.17 | 27 | 76313 | 32627 | 31588377 |
Fear | 22.75 | 11.17 | 64 | 76276 | 9910 | 31611094 |
Lactic acidosis | 22.73 | 11.17 | 26 | 76314 | 31911 | 31589093 |
Nasal discomfort | 22.68 | 11.17 | 23 | 76317 | 1517 | 31619487 |
Encephalopathy | 22.51 | 11.17 | 27 | 76313 | 32447 | 31588557 |
Hyperkaliuria | 22.31 | 11.17 | 9 | 76331 | 110 | 31620894 |
Palmar-plantar erythrodysaesthesia syndrome | 22.25 | 11.17 | 5 | 76335 | 15478 | 31605526 |
Meningitis eosinophilic | 22.17 | 11.17 | 6 | 76334 | 17 | 31620987 |
Self-injurious ideation | 22.10 | 11.17 | 23 | 76317 | 1564 | 31619440 |
Hypoglycaemia | 22.03 | 11.17 | 57 | 76283 | 50889 | 31570115 |
White blood cell count decreased | 22 | 11.17 | 122 | 76218 | 87276 | 31533728 |
Chronic spontaneous urticaria | 21.93 | 11.17 | 10 | 76330 | 168 | 31620836 |
Bronchiolitis obliterans syndrome | 21.93 | 11.17 | 10 | 76330 | 168 | 31620836 |
Allergic respiratory disease | 21.84 | 11.17 | 7 | 76333 | 41 | 31620963 |
Lower respiratory tract congestion | 21.82 | 11.17 | 19 | 76321 | 1033 | 31619971 |
NPM1 gene mutation | 21.81 | 11.17 | 9 | 76331 | 117 | 31620887 |
Tearfulness | 21.74 | 11.17 | 25 | 76315 | 1902 | 31619102 |
Blood bilirubin increased | 21.52 | 11.17 | 32 | 76308 | 35104 | 31585900 |
Acute myeloid leukaemia | 21.50 | 11.17 | 9 | 76331 | 18663 | 31602341 |
Gastroenteritis viral | 21.44 | 11.17 | 47 | 76293 | 6230 | 31614774 |
Stomatitis | 21.29 | 11.17 | 39 | 76301 | 39399 | 31581605 |
Mite allergy | 21.12 | 11.17 | 13 | 76327 | 410 | 31620594 |
Temperature intolerance | 21.07 | 11.17 | 31 | 76309 | 3008 | 31617996 |
Neuropsychiatric symptoms | 20.95 | 11.17 | 14 | 76326 | 510 | 31620494 |
Hyperglycaemia | 20.66 | 11.17 | 35 | 76305 | 36441 | 31584563 |
Dysphonia | 20.45 | 11.17 | 101 | 76239 | 20490 | 31600514 |
Rhonchi | 20.30 | 11.17 | 23 | 76317 | 1722 | 31619282 |
Respiratory symptom | 20.14 | 11.17 | 20 | 76320 | 1286 | 31619718 |
Hypohidrosis | 20.08 | 11.17 | 10 | 76330 | 206 | 31620798 |
Urinary tract infection | 20.06 | 11.17 | 106 | 76234 | 76763 | 31544241 |
Alanine aminotransferase increased | 20.02 | 11.17 | 102 | 76238 | 74554 | 31546450 |
Child abuse | 19.95 | 11.17 | 12 | 76328 | 363 | 31620641 |
Sputum abnormal | 19.89 | 11.17 | 13 | 76327 | 456 | 31620548 |
Respiratory tract irritation | 19.74 | 11.17 | 9 | 76331 | 151 | 31620853 |
Stiff person syndrome | 19.67 | 11.17 | 8 | 76332 | 100 | 31620904 |
Abnormal dreams | 19.66 | 11.17 | 49 | 76291 | 7059 | 31613945 |
Tubulointerstitial nephritis | 19.61 | 11.17 | 10 | 76330 | 18486 | 31602518 |
Mononeuropathy multiplex | 19.58 | 11.17 | 9 | 76331 | 154 | 31620850 |
Lung hernia | 19.35 | 11.17 | 7 | 76333 | 62 | 31620942 |
Status epilepticus | 19.34 | 11.17 | 3 | 76337 | 12103 | 31608901 |
Airway remodelling | 19.22 | 11.17 | 9 | 76331 | 161 | 31620843 |
Obsessive-compulsive disorder | 19.22 | 11.17 | 39 | 76301 | 4898 | 31616106 |
Secretion discharge | 19.22 | 11.17 | 39 | 76301 | 4898 | 31616106 |
Blood urea increased | 19.19 | 11.17 | 25 | 76315 | 28987 | 31592017 |
Pneumocystis jirovecii pneumonia | 19.16 | 11.17 | 10 | 76330 | 18241 | 31602763 |
Haematuria | 19.13 | 11.17 | 53 | 76287 | 46261 | 31574743 |
Physical assault | 19.11 | 11.17 | 18 | 76322 | 1084 | 31619920 |
Nocturnal dyspnoea | 19.11 | 11.17 | 13 | 76327 | 488 | 31620516 |
Sedation | 19.02 | 11.17 | 11 | 76329 | 18954 | 31602050 |
Forced expiratory flow decreased | 19.02 | 11.17 | 9 | 76331 | 165 | 31620839 |
Bronchitis viral | 18.97 | 11.17 | 10 | 76330 | 233 | 31620771 |
Scleroderma | 18.90 | 11.17 | 20 | 76320 | 1387 | 31619617 |
Decreased appetite | 18.76 | 11.17 | 258 | 76082 | 152959 | 31468045 |
Self esteem decreased | 18.74 | 11.17 | 13 | 76327 | 504 | 31620500 |
Nasal septum deviation | 18.62 | 11.17 | 17 | 76323 | 984 | 31620020 |
Diaphragmatic disorder | 18.58 | 11.17 | 18 | 76322 | 1123 | 31619881 |
Acute respiratory distress syndrome | 18.55 | 11.17 | 19 | 76321 | 24521 | 31596483 |
Upper respiratory tract congestion | 18.42 | 11.17 | 15 | 76325 | 743 | 31620261 |
Cerebrovascular accident | 18.38 | 11.17 | 114 | 76226 | 79370 | 31541634 |
Pyrexia | 18.30 | 11.17 | 575 | 75765 | 303265 | 31317739 |
Hepatocellular injury | 18.28 | 11.17 | 15 | 76325 | 21529 | 31599475 |
Mast cell activation syndrome | 18.22 | 11.17 | 9 | 76331 | 182 | 31620822 |
Somnambulism | 18.22 | 11.17 | 28 | 76312 | 2824 | 31618180 |
Migraine | 18.16 | 11.17 | 75 | 76265 | 14105 | 31606899 |
Sopor | 18.14 | 11.17 | 3 | 76337 | 11549 | 31609455 |
Vomiting | 17.61 | 11.17 | 408 | 75932 | 223565 | 31397439 |
Mental disorder | 17.59 | 11.17 | 73 | 76267 | 13761 | 31607243 |
Fall | 17.57 | 11.17 | 329 | 76011 | 185760 | 31435244 |
Hyperbilirubinaemia | 17.49 | 11.17 | 8 | 76332 | 15742 | 31605262 |
Altered state of consciousness | 17.44 | 11.17 | 15 | 76325 | 21036 | 31599968 |
Benign prostatic hyperplasia | 17.27 | 11.17 | 70 | 76270 | 13055 | 31607949 |
Angina pectoris | 17.19 | 11.17 | 28 | 76312 | 29613 | 31591391 |
Weight increased | 17.17 | 11.17 | 288 | 76052 | 82659 | 31538345 |
Steroid diabetes | 17.12 | 11.17 | 22 | 76318 | 1878 | 31619126 |
Bone density decreased | 17.09 | 11.17 | 21 | 76319 | 1714 | 31619290 |
Neutrophil count decreased | 17.07 | 11.17 | 56 | 76284 | 46338 | 31574666 |
Cortisol decreased | 16.91 | 11.17 | 16 | 76324 | 969 | 31620035 |
Depressed level of consciousness | 16.83 | 11.17 | 43 | 76297 | 38558 | 31582446 |
Poor quality device used | 16.73 | 11.17 | 15 | 76325 | 848 | 31620156 |
Alopecia areata | 16.68 | 11.17 | 9 | 76331 | 220 | 31620784 |
Treatment failure | 16.61 | 11.17 | 47 | 76293 | 40745 | 31580259 |
Disseminated intravascular coagulation | 16.57 | 11.17 | 15 | 76325 | 20522 | 31600482 |
Total lung capacity decreased | 16.50 | 11.17 | 13 | 76327 | 614 | 31620390 |
Oedema peripheral | 16.46 | 11.17 | 177 | 76163 | 109662 | 31511342 |
Unresponsive to stimuli | 16.29 | 11.17 | 23 | 76317 | 25777 | 31595227 |
Haematochezia | 16.20 | 11.17 | 47 | 76293 | 40417 | 31580587 |
Chimerism | 16.18 | 11.17 | 9 | 76331 | 234 | 31620770 |
Pulmonary oedema | 16.18 | 11.17 | 54 | 76286 | 44448 | 31576556 |
Feeling abnormal | 16.16 | 11.17 | 209 | 76131 | 56793 | 31564211 |
Growth retardation | 15.99 | 11.17 | 20 | 76320 | 1662 | 31619342 |
Agitation | 15.94 | 11.17 | 200 | 76140 | 53969 | 31567035 |
Intentional product use issue | 15.88 | 11.17 | 63 | 76277 | 49284 | 31571720 |
Nasal mucosal disorder | 15.77 | 11.17 | 7 | 76333 | 110 | 31620894 |
Sputum retention | 15.75 | 11.17 | 11 | 76329 | 431 | 31620573 |
Prostatomegaly | 15.73 | 11.17 | 36 | 76304 | 4911 | 31616093 |
Hypercalcaemia | 15.72 | 11.17 | 7 | 76333 | 13993 | 31607011 |
Glaucoma | 15.60 | 11.17 | 42 | 76298 | 6338 | 31614666 |
Aspartate aminotransferase increased | 15.53 | 11.17 | 88 | 76252 | 62631 | 31558373 |
Small airways disease | 15.50 | 11.17 | 5 | 76335 | 30 | 31620974 |
Hostility | 15.44 | 11.17 | 14 | 76326 | 803 | 31620201 |
Behaviour disorder | 15.36 | 11.17 | 33 | 76307 | 4314 | 31616690 |
Eosinophilic oesophagitis | 15.30 | 11.17 | 9 | 76331 | 261 | 31620743 |
Plasma cell myeloma | 15.29 | 11.17 | 77 | 76263 | 56454 | 31564550 |
Hypomagnesaemia | 15.28 | 11.17 | 14 | 76326 | 19044 | 31601960 |
Circulatory collapse | 15.25 | 11.17 | 15 | 76325 | 19729 | 31601275 |
Peritonitis | 15.22 | 11.17 | 9 | 76331 | 15318 | 31605686 |
Shock haemorrhagic | 15.21 | 11.17 | 3 | 76337 | 10174 | 31610830 |
Subdural haematoma | 15.14 | 11.17 | 14 | 76326 | 18957 | 31602047 |
Bronchiolitis | 15.14 | 11.17 | 26 | 76314 | 2878 | 31618126 |
Affective disorder | 15.13 | 11.17 | 30 | 76310 | 3706 | 31617298 |
ACTH stimulation test abnormal | 15.09 | 11.17 | 3 | 76337 | 0 | 31621004 |
Pigmentary glaucoma | 15.09 | 11.17 | 3 | 76337 | 0 | 31621004 |
Cephalo-pelvic disproportion | 15.09 | 11.17 | 3 | 76337 | 0 | 31621004 |
Exophthalmos congenital | 15.09 | 11.17 | 3 | 76337 | 0 | 31621004 |
Seizure anoxic | 15.09 | 11.17 | 3 | 76337 | 0 | 31621004 |
Hepatic encephalopathy | 15.09 | 11.17 | 7 | 76333 | 13664 | 31607340 |
Lung disorder | 15.06 | 11.17 | 131 | 76209 | 32181 | 31588823 |
Spirometry abnormal | 15.04 | 11.17 | 11 | 76329 | 464 | 31620540 |
Bronchopulmonary aspergillosis | 15.02 | 11.17 | 7 | 76333 | 13627 | 31607377 |
Oropharyngeal discomfort | 14.96 | 11.17 | 25 | 76315 | 2706 | 31618298 |
Vasculitis | 14.95 | 11.17 | 50 | 76290 | 8500 | 31612504 |
Drug level increased | 14.84 | 11.17 | 16 | 76324 | 20170 | 31600834 |
Frustration tolerance decreased | 14.78 | 11.17 | 23 | 76317 | 2345 | 31618659 |
Hospitalisation | 14.70 | 11.17 | 184 | 76156 | 49623 | 31571381 |
Extrapyramidal disorder | 14.69 | 11.17 | 5 | 76335 | 11773 | 31609231 |
Allergy to plants | 14.61 | 11.17 | 4 | 76336 | 12 | 31620992 |
Haemophilus infection | 14.57 | 11.17 | 15 | 76325 | 1007 | 31619997 |
Central obesity | 14.52 | 11.17 | 11 | 76329 | 490 | 31620514 |
Ocular hyperaemia | 14.48 | 11.17 | 55 | 76285 | 9954 | 31611050 |
Hemiparesis | 14.43 | 11.17 | 9 | 76331 | 14885 | 31606119 |
Clostridium difficile colitis | 14.32 | 11.17 | 8 | 76332 | 14048 | 31606956 |
Device related infection | 14.27 | 11.17 | 11 | 76329 | 16288 | 31604716 |
Hepatotoxicity | 14.24 | 11.17 | 15 | 76325 | 19111 | 31601893 |
Renal tubular necrosis | 14.19 | 11.17 | 9 | 76331 | 14750 | 31606254 |
Diabetic ketoacidosis | 14.06 | 11.17 | 12 | 76328 | 16893 | 31604111 |
Idiopathic intracranial hypertension | 14.01 | 11.17 | 12 | 76328 | 638 | 31620366 |
Human ehrlichiosis | 13.98 | 11.17 | 8 | 76332 | 220 | 31620784 |
Juvenile idiopathic arthritis | 13.97 | 11.17 | 19 | 76321 | 1714 | 31619290 |
Actinic keratosis | 13.94 | 11.17 | 31 | 76309 | 4148 | 31616856 |
Disturbance in social behaviour | 13.72 | 11.17 | 19 | 76321 | 1744 | 31619260 |
Cytokine release syndrome | 13.61 | 11.17 | 12 | 76328 | 16630 | 31604374 |
Deep vein thrombosis | 13.58 | 11.17 | 88 | 76252 | 60648 | 31560356 |
Swelling face | 13.46 | 11.17 | 93 | 76247 | 21297 | 31599707 |
Injection site swelling | 13.43 | 11.17 | 54 | 76286 | 10033 | 31610971 |
Lymphopenia | 13.42 | 11.17 | 9 | 76331 | 14320 | 31606684 |
Injection site pruritus | 13.40 | 11.17 | 39 | 76301 | 6155 | 31614849 |
Metastases to liver | 13.32 | 11.17 | 7 | 76333 | 12720 | 31608284 |
Dysphagia | 13.19 | 11.17 | 83 | 76257 | 57593 | 31563411 |
Hand-foot-and-mouth disease | 13.11 | 11.17 | 5 | 76335 | 52 | 31620952 |
COVID-19 | 13.10 | 11.17 | 195 | 76145 | 54626 | 31566378 |
Respiration abnormal | 13.08 | 11.17 | 24 | 76316 | 2798 | 31618206 |
Atopy | 13.05 | 11.17 | 7 | 76333 | 169 | 31620835 |
Conjunctivitis | 12.99 | 11.17 | 48 | 76292 | 8575 | 31612429 |
Ischaemic stroke | 12.99 | 11.17 | 13 | 76327 | 16958 | 31604046 |
Choking | 12.97 | 11.17 | 32 | 76308 | 4580 | 31616424 |
Kidney infection | 12.96 | 11.17 | 33 | 76307 | 4817 | 31616187 |
Prolonged expiration | 12.94 | 11.17 | 7 | 76333 | 172 | 31620832 |
Mycobacterial infection | 12.92 | 11.17 | 21 | 76319 | 2222 | 31618782 |
Facial discomfort | 12.85 | 11.17 | 4 | 76336 | 21 | 31620983 |
Haematocrit decreased | 12.71 | 11.17 | 34 | 76306 | 30027 | 31590977 |
Hallucination, auditory | 12.65 | 11.17 | 54 | 76286 | 10306 | 31610698 |
Shock | 12.57 | 11.17 | 22 | 76318 | 22623 | 31598381 |
Separation anxiety disorder | 12.56 | 11.17 | 3 | 76337 | 4 | 31621000 |
Anuria | 12.53 | 11.17 | 4 | 76336 | 9810 | 31611194 |
Chronic kidney disease | 12.53 | 11.17 | 48 | 76292 | 37927 | 31583077 |
Duodenal ulcer | 12.43 | 11.17 | 4 | 76336 | 9760 | 31611244 |
Eosinophil count abnormal | 12.41 | 11.17 | 8 | 76332 | 274 | 31620730 |
Coronary artery disease | 12.33 | 11.17 | 63 | 76277 | 46024 | 31574980 |
Myelodysplastic syndrome | 12.31 | 11.17 | 17 | 76323 | 19234 | 31601770 |
Disease prodromal stage | 12.26 | 11.17 | 4 | 76336 | 25 | 31620979 |
Electrolyte imbalance | 12.25 | 11.17 | 7 | 76333 | 12141 | 31608863 |
Hepatocellular carcinoma | 12.24 | 11.17 | 3 | 76337 | 8753 | 31612251 |
Interstitial lung disease | 12.24 | 11.17 | 92 | 76248 | 61311 | 31559693 |
Dysarthria | 12.23 | 11.17 | 38 | 76302 | 31979 | 31589025 |
Stridor | 12.22 | 11.17 | 21 | 76319 | 2326 | 31618678 |
Dermatitis allergic | 12.21 | 11.17 | 37 | 76303 | 5972 | 31615032 |
Eye irritation | 12.19 | 11.17 | 39 | 76301 | 6479 | 31614525 |
Onychophagia | 12.19 | 11.17 | 5 | 76335 | 64 | 31620940 |
Fight in school | 12.16 | 11.17 | 3 | 76337 | 5 | 31620999 |
Tachycardia | 12.15 | 11.17 | 121 | 76219 | 76086 | 31544918 |
Acute hepatic failure | 12.15 | 11.17 | 8 | 76332 | 12851 | 31608153 |
Sinus bradycardia | 12.14 | 11.17 | 7 | 76333 | 12080 | 31608924 |
Rhinalgia | 12.10 | 11.17 | 9 | 76331 | 390 | 31620614 |
Hyposmia | 12.02 | 11.17 | 7 | 76333 | 199 | 31620805 |
Graft versus host disease in lung | 12.01 | 11.17 | 10 | 76330 | 511 | 31620493 |
Product taste abnormal | 11.95 | 11.17 | 14 | 76326 | 1087 | 31619917 |
Quality of life decreased | 11.95 | 11.17 | 26 | 76314 | 3429 | 31617575 |
Haemodynamic instability | 11.87 | 11.17 | 3 | 76337 | 8572 | 31612432 |
Atrioventricular block complete | 11.85 | 11.17 | 3 | 76337 | 8562 | 31612442 |
Liver function test decreased | 11.78 | 11.17 | 5 | 76335 | 70 | 31620934 |
Subarachnoid haemorrhage | 11.75 | 11.17 | 5 | 76335 | 10266 | 31610738 |
Gastrointestinal tract mucosal pigmentation | 11.72 | 11.17 | 9 | 76331 | 409 | 31620595 |
Posterior reversible encephalopathy syndrome | 11.64 | 11.17 | 4 | 76336 | 9363 | 31611641 |
Metastases to lung | 11.55 | 11.17 | 3 | 76337 | 8419 | 31612585 |
Myoclonus | 11.55 | 11.17 | 10 | 76330 | 13980 | 31607024 |
Proteinuria | 11.55 | 11.17 | 14 | 76326 | 16749 | 31604255 |
Liver disorder | 11.53 | 11.17 | 35 | 76305 | 29672 | 31591332 |
Premature baby | 11.51 | 11.17 | 16 | 76324 | 18050 | 31602954 |
Breath holding | 11.50 | 11.17 | 3 | 76337 | 7 | 31620997 |
Occupational exposure to dust | 11.50 | 11.17 | 3 | 76337 | 7 | 31620997 |
Episcleritis | 11.49 | 11.17 | 6 | 76334 | 137 | 31620867 |
Social problem | 11.45 | 11.17 | 12 | 76328 | 823 | 31620181 |
Blood creatine phosphokinase increased | 11.44 | 11.17 | 57 | 76283 | 41917 | 31579087 |
Breech presentation | 11.41 | 11.17 | 6 | 76334 | 139 | 31620865 |
Pain | 11.32 | 11.17 | 353 | 75987 | 186406 | 31434598 |
Cerebral infarction | 11.27 | 11.17 | 29 | 76311 | 25948 | 31595056 |
Schizophrenia | 11.27 | 11.17 | 6 | 76334 | 10824 | 31610180 |
Hepatic cytolysis | 11.26 | 11.17 | 6 | 76334 | 10817 | 31610187 |
Bronchial disorder | 11.20 | 11.17 | 15 | 76325 | 1334 | 31619670 |
Airway complication of anaesthesia | 11.18 | 11.17 | 6 | 76334 | 145 | 31620859 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Asthma | 7827.75 | 10.14 | 4737 | 208978 | 116056 | 70598673 |
Wheezing | 2612.69 | 10.14 | 2207 | 211508 | 91963 | 70622766 |
Eosinophilic granulomatosis with polyangiitis | 1751.20 | 10.14 | 567 | 213148 | 2646 | 70712083 |
Obstructive airways disorder | 1354.06 | 10.14 | 892 | 212823 | 25221 | 70689508 |
Cough | 1099.19 | 10.14 | 2774 | 210941 | 322603 | 70392126 |
Dyspnoea | 902.38 | 10.14 | 4631 | 209084 | 765429 | 69949300 |
Productive cough | 886.91 | 10.14 | 1136 | 212579 | 77201 | 70637528 |
Forced expiratory volume decreased | 875.92 | 10.14 | 432 | 213283 | 6882 | 70707847 |
Full blood count abnormal | 830.89 | 10.14 | 741 | 212974 | 33137 | 70681592 |
Sputum discoloured | 815.78 | 10.14 | 576 | 213139 | 18275 | 70696454 |
Toxicity to various agents | 621.35 | 10.14 | 190 | 213525 | 381982 | 70332747 |
Sleep disorder due to a general medical condition | 604.81 | 10.14 | 383 | 213332 | 10093 | 70704636 |
Chest discomfort | 603.52 | 10.14 | 1226 | 212489 | 123155 | 70591574 |
Sleep terror | 493.89 | 10.14 | 172 | 213543 | 1043 | 70713686 |
Nasal congestion | 478.97 | 10.14 | 773 | 212942 | 64899 | 70649830 |
Nightmare | 466.26 | 10.14 | 445 | 213270 | 21711 | 70693018 |
Urticaria | 460.78 | 10.14 | 1303 | 212412 | 161746 | 70552983 |
Middle insomnia | 410.82 | 10.14 | 340 | 213375 | 13713 | 70701016 |
Blood immunoglobulin E increased | 357.99 | 10.14 | 206 | 213509 | 4538 | 70710191 |
Acute kidney injury | 356.35 | 10.14 | 550 | 213165 | 474074 | 70240655 |
Nasal polyps | 340.52 | 10.14 | 196 | 213519 | 4320 | 70710409 |
Sinusitis | 336.47 | 10.14 | 1198 | 212517 | 167997 | 70546732 |
Bronchitis | 326.20 | 10.14 | 932 | 212783 | 116311 | 70598418 |
Suicidal ideation | 321.97 | 10.14 | 673 | 213042 | 68923 | 70645806 |
Gastrooesophageal reflux disease | 314.31 | 10.14 | 783 | 212932 | 90056 | 70624673 |
Chronic obstructive pulmonary disease | 313.83 | 10.14 | 711 | 213004 | 76930 | 70637799 |
Food allergy | 311.01 | 10.14 | 235 | 213480 | 8289 | 70706440 |
Abnormal behaviour | 307.16 | 10.14 | 447 | 213268 | 34262 | 70680467 |
Therapeutic product effect incomplete | 294.59 | 10.14 | 912 | 212803 | 118970 | 70595759 |
Off label use | 291.81 | 10.14 | 1202 | 212513 | 741858 | 69972871 |
Rhinitis allergic | 290.86 | 10.14 | 234 | 213481 | 9061 | 70705668 |
Synovitis | 287.98 | 10.14 | 28 | 213687 | 129200 | 70585529 |
Aggression | 286.91 | 10.14 | 520 | 213195 | 47926 | 70666803 |
Drug interaction | 269.22 | 10.14 | 460 | 213255 | 380981 | 70333748 |
Anaemia | 263.77 | 10.14 | 510 | 213205 | 402913 | 70311816 |
Seasonal allergy | 263.36 | 10.14 | 260 | 213455 | 13224 | 70701505 |
Neutropenia | 258.96 | 10.14 | 236 | 213479 | 256920 | 70457809 |
Asthmatic crisis | 254.90 | 10.14 | 121 | 213594 | 1763 | 70712966 |
Influenza | 252.95 | 10.14 | 836 | 212879 | 112864 | 70601865 |
Upper respiratory tract infection | 243.99 | 10.14 | 654 | 213061 | 78620 | 70636109 |
Completed suicide | 243.86 | 10.14 | 196 | 213519 | 226939 | 70487790 |
Dyspnoea exertional | 228.37 | 10.14 | 634 | 213081 | 77796 | 70636933 |
Pemphigus | 225.77 | 10.14 | 5 | 213710 | 83031 | 70631698 |
Hand deformity | 224.86 | 10.14 | 8 | 213707 | 86474 | 70628255 |
Anger | 223.03 | 10.14 | 259 | 213456 | 15873 | 70698856 |
Breath sounds abnormal | 221.86 | 10.14 | 235 | 213480 | 12996 | 70701733 |
Eosinophil count increased | 219.90 | 10.14 | 250 | 213465 | 14972 | 70699757 |
Thrombocytopenia | 218.29 | 10.14 | 239 | 213476 | 238871 | 70475858 |
Drug abuse | 216.89 | 10.14 | 86 | 213629 | 147170 | 70567559 |
Anxiety | 215.96 | 10.14 | 1266 | 212449 | 219064 | 70495665 |
Sleep apnoea syndrome | 215.52 | 10.14 | 368 | 213347 | 32345 | 70682384 |
Pancytopenia | 214.89 | 10.14 | 93 | 213622 | 151014 | 70563715 |
Febrile neutropenia | 213.50 | 10.14 | 181 | 213534 | 204137 | 70510592 |
Rheumatoid arthritis | 213.10 | 10.14 | 344 | 213371 | 291461 | 70423268 |
Loss of personal independence in daily activities | 208.55 | 10.14 | 646 | 213069 | 84264 | 70630465 |
Temperature regulation disorder | 206.73 | 10.14 | 142 | 213573 | 4302 | 70710427 |
Infective pulmonary exacerbation of cystic fibrosis | 203.96 | 10.14 | 216 | 213499 | 11942 | 70702787 |
Impaired quality of life | 198.89 | 10.14 | 185 | 213530 | 8731 | 70705998 |
Rhinorrhoea | 197.65 | 10.14 | 541 | 213174 | 65830 | 70648899 |
Upper-airway cough syndrome | 196.31 | 10.14 | 191 | 213524 | 9540 | 70705189 |
Treatment failure | 192.17 | 10.14 | 97 | 213618 | 144045 | 70570684 |
Headache | 189.29 | 10.14 | 2619 | 211096 | 577786 | 70136943 |
Hypotension | 185.20 | 10.14 | 613 | 213102 | 403768 | 70310961 |
Malignant neoplasm progression | 184.42 | 10.14 | 68 | 213647 | 121671 | 70593058 |
Eosinophilia | 181.88 | 10.14 | 386 | 213329 | 39933 | 70674796 |
Polycystic ovaries | 178.35 | 10.14 | 110 | 213605 | 2762 | 70711967 |
Death | 176.33 | 10.14 | 864 | 212851 | 509197 | 70205532 |
Bronchial secretion retention | 173.61 | 10.14 | 110 | 213605 | 2900 | 70711829 |
Anaphylactic reaction | 170.02 | 10.14 | 555 | 213160 | 74419 | 70640310 |
Bronchospasm | 169.78 | 10.14 | 271 | 213444 | 22521 | 70692208 |
Blood test abnormal | 165.56 | 10.14 | 212 | 213503 | 14378 | 70700351 |
Pericarditis | 165.47 | 10.14 | 28 | 213687 | 84677 | 70630052 |
Respiratory tract congestion | 162.97 | 10.14 | 232 | 213483 | 17421 | 70697308 |
Rhinitis | 160.65 | 10.14 | 186 | 213529 | 11361 | 70703368 |
Product quality issue | 159.71 | 10.14 | 311 | 213404 | 30250 | 70684479 |
Product dose omission issue | 157.82 | 10.14 | 1159 | 212556 | 216309 | 70498420 |
Respiratory tract infection | 157.79 | 10.14 | 376 | 213339 | 42022 | 70672707 |
Joint swelling | 157.66 | 10.14 | 329 | 213386 | 252882 | 70461847 |
Hyponatraemia | 157.41 | 10.14 | 150 | 213565 | 159937 | 70554792 |
Pulmonary function test decreased | 157.30 | 10.14 | 144 | 213571 | 6657 | 70708072 |
Pulmonary function test abnormal | 155.93 | 10.14 | 108 | 213607 | 3317 | 70711412 |
Multiple organ dysfunction syndrome | 152.34 | 10.14 | 68 | 213647 | 108447 | 70606282 |
Arthropathy | 150.60 | 10.14 | 138 | 213577 | 149919 | 70564810 |
Nasopharyngitis | 149.29 | 10.14 | 1163 | 212552 | 221043 | 70493686 |
Coeliac disease | 148.90 | 10.14 | 159 | 213556 | 8874 | 70705855 |
Mood altered | 148.39 | 10.14 | 214 | 213501 | 16261 | 70698468 |
Crying | 148.31 | 10.14 | 245 | 213470 | 20954 | 70693775 |
Drug intolerance | 146.67 | 10.14 | 286 | 213429 | 225401 | 70489328 |
Systemic lupus erythematosus | 145.99 | 10.14 | 62 | 213653 | 101840 | 70612889 |
Heart rate increased | 144.83 | 10.14 | 669 | 213046 | 105479 | 70609250 |
Sensitivity to weather change | 143.15 | 10.14 | 142 | 213573 | 7263 | 70707466 |
Contraindicated product administered | 142.10 | 10.14 | 118 | 213597 | 134494 | 70580235 |
Glossodynia | 142.04 | 10.14 | 42 | 213673 | 86445 | 70628284 |
Pneumonia | 140.98 | 10.14 | 2550 | 211165 | 593682 | 70121047 |
Oropharyngeal pain | 137.35 | 10.14 | 615 | 213100 | 95695 | 70619034 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 137.27 | 10.14 | 75 | 213640 | 1489 | 70713240 |
Sensitisation | 136.73 | 10.14 | 88 | 213627 | 2385 | 70712344 |
Bronchiectasis | 136.17 | 10.14 | 203 | 213512 | 15894 | 70698835 |
Depression | 135.07 | 10.14 | 1044 | 212671 | 197930 | 70516799 |
General physical health deterioration | 130.46 | 10.14 | 327 | 213388 | 235704 | 70479025 |
Secretion discharge | 129.88 | 10.14 | 177 | 213538 | 12756 | 70701973 |
Stomatitis | 127.98 | 10.14 | 119 | 213596 | 128392 | 70586337 |
Renal impairment | 127.85 | 10.14 | 147 | 213568 | 143790 | 70570939 |
Sputum increased | 126.31 | 10.14 | 102 | 213613 | 3970 | 70710759 |
Chronic spontaneous urticaria | 125.26 | 10.14 | 63 | 213652 | 1048 | 70713681 |
Vital capacity decreased | 124.86 | 10.14 | 68 | 213647 | 1341 | 70713388 |
Pruritus | 124.62 | 10.14 | 1589 | 212126 | 343971 | 70370758 |
Disease progression | 123.62 | 10.14 | 175 | 213540 | 156497 | 70558232 |
Helicobacter infection | 121.51 | 10.14 | 13 | 213702 | 55643 | 70659086 |
Infusion related reaction | 120.95 | 10.14 | 259 | 213456 | 197275 | 70517454 |
Blood pressure systolic increased | 120.17 | 10.14 | 413 | 213302 | 56846 | 70657883 |
Dermatitis atopic | 120.16 | 10.14 | 142 | 213573 | 8865 | 70705864 |
Therapeutic product effect decreased | 119.68 | 10.14 | 153 | 213562 | 142865 | 70571864 |
Illness | 119.44 | 10.14 | 283 | 213432 | 31508 | 70683221 |
Confusional state | 119.41 | 10.14 | 447 | 213268 | 283951 | 70430778 |
Sneezing | 118.71 | 10.14 | 196 | 213519 | 16755 | 70697974 |
Perfume sensitivity | 116.41 | 10.14 | 53 | 213662 | 698 | 70714031 |
Peak expiratory flow rate decreased | 116.24 | 10.14 | 51 | 213664 | 612 | 70714117 |
Multiple allergies | 114.72 | 10.14 | 129 | 213586 | 7631 | 70707098 |
Bronchial wall thickening | 114.25 | 10.14 | 75 | 213640 | 2104 | 70712625 |
Forced vital capacity decreased | 113.81 | 10.14 | 67 | 213648 | 1542 | 70713187 |
Leukopenia | 111.73 | 10.14 | 94 | 213621 | 106466 | 70608263 |
Septic shock | 111.72 | 10.14 | 104 | 213611 | 112154 | 70602575 |
Eye pruritus | 111.63 | 10.14 | 176 | 213539 | 14471 | 70700258 |
Eczema | 111.34 | 10.14 | 286 | 213429 | 33495 | 70681234 |
Bronchial obstruction | 111.03 | 10.14 | 78 | 213637 | 2452 | 70712277 |
Sepsis | 109.53 | 10.14 | 374 | 213341 | 244171 | 70470558 |
Intentional overdose | 109.28 | 10.14 | 82 | 213633 | 98353 | 70616376 |
Respiratory rate increased | 108.70 | 10.14 | 205 | 213510 | 19467 | 70695262 |
Throat clearing | 107.44 | 10.14 | 66 | 213649 | 1645 | 70713084 |
Dust allergy | 107.31 | 10.14 | 58 | 213657 | 1126 | 70713603 |
Diarrhoea | 105.45 | 10.14 | 1694 | 212021 | 781647 | 69933082 |
Haemoglobin decreased | 105.18 | 10.14 | 295 | 213420 | 204864 | 70509865 |
C-reactive protein increased | 104.64 | 10.14 | 107 | 213608 | 110410 | 70604319 |
Reversible airways obstruction | 103.50 | 10.14 | 63 | 213652 | 1544 | 70713185 |
Rhabdomyolysis | 103.47 | 10.14 | 82 | 213633 | 95678 | 70619051 |
Irritability | 103.41 | 10.14 | 301 | 213414 | 37924 | 70676805 |
Insomnia | 102.95 | 10.14 | 1056 | 212659 | 216750 | 70497979 |
Ejection fraction | 100.64 | 10.14 | 64 | 213651 | 1698 | 70713031 |
Dysphonia | 100.48 | 10.14 | 356 | 213359 | 49744 | 70664985 |
Coma | 98.79 | 10.14 | 79 | 213636 | 91765 | 70622964 |
Intentional product use issue | 97.97 | 10.14 | 131 | 213584 | 120011 | 70594718 |
Platelet count decreased | 97.60 | 10.14 | 248 | 213467 | 177974 | 70536755 |
Lung hyperinflation | 97.03 | 10.14 | 62 | 213653 | 1659 | 70713070 |
Blood creatinine increased | 96.56 | 10.14 | 177 | 213538 | 142824 | 70571905 |
Bone marrow failure | 96.15 | 10.14 | 16 | 213699 | 48994 | 70665735 |
Total lung capacity increased | 96.13 | 10.14 | 50 | 213665 | 895 | 70713834 |
Muscle injury | 95.30 | 10.14 | 5 | 213710 | 38489 | 70676240 |
Status asthmaticus | 95.29 | 10.14 | 51 | 213664 | 970 | 70713759 |
Aspirin-exacerbated respiratory disease | 95.00 | 10.14 | 54 | 213661 | 1161 | 70713568 |
Mucosal inflammation | 94.46 | 10.14 | 43 | 213672 | 67807 | 70646922 |
Sinus congestion | 93.46 | 10.14 | 179 | 213536 | 17194 | 70697535 |
Chronic sinusitis | 91.51 | 10.14 | 120 | 213595 | 8331 | 70706398 |
Blood pressure increased | 91.47 | 10.14 | 919 | 212796 | 187598 | 70527131 |
Nasal oedema | 91.33 | 10.14 | 54 | 213661 | 1253 | 70713476 |
Hyperkalaemia | 91.28 | 10.14 | 112 | 213603 | 106479 | 70608250 |
Allergy to animal | 91.27 | 10.14 | 52 | 213663 | 1123 | 70713606 |
Malaise | 90.89 | 10.14 | 1819 | 211896 | 431113 | 70283616 |
Mood swings | 90.61 | 10.14 | 182 | 213533 | 18104 | 70696625 |
Hypoventilation | 88.19 | 10.14 | 104 | 213611 | 6478 | 70708251 |
Impaired healing | 87.77 | 10.14 | 58 | 213657 | 74316 | 70640413 |
Bronchopulmonary aspergillosis allergic | 87.09 | 10.14 | 61 | 213654 | 1908 | 70712821 |
Rales | 86.65 | 10.14 | 172 | 213543 | 16963 | 70697766 |
Metabolic acidosis | 86.36 | 10.14 | 59 | 213656 | 74287 | 70640442 |
Bronchial hyperreactivity | 86.19 | 10.14 | 68 | 213647 | 2558 | 70712171 |
Folliculitis | 85.54 | 10.14 | 13 | 213702 | 42557 | 70672172 |
Wound | 85.33 | 10.14 | 103 | 213612 | 98629 | 70616100 |
Restrictive pulmonary disease | 85.06 | 10.14 | 64 | 213651 | 2242 | 70712487 |
Hypersensitivity | 84.96 | 10.14 | 1062 | 212653 | 228750 | 70485979 |
Respiratory disorder | 84.55 | 10.14 | 285 | 213430 | 38838 | 70675891 |
Bradycardia | 84.34 | 10.14 | 154 | 213561 | 124461 | 70590268 |
Renal failure | 84.06 | 10.14 | 290 | 213425 | 188780 | 70525949 |
Poor quality device used | 83.61 | 10.14 | 61 | 213654 | 2037 | 70712692 |
Respiratory symptom | 83.46 | 10.14 | 78 | 213637 | 3703 | 70711026 |
Vocal cord dysfunction | 82.49 | 10.14 | 36 | 213679 | 426 | 70714303 |
Cardiac failure | 82.30 | 10.14 | 195 | 213520 | 143346 | 70571383 |
C-reactive protein abnormal | 81.74 | 10.14 | 10 | 213705 | 38569 | 70676160 |
Sinus disorder | 81.46 | 10.14 | 178 | 213537 | 18781 | 70695948 |
Immunodeficiency | 81.40 | 10.14 | 170 | 213545 | 17385 | 70697344 |
Cardiac arrest | 81.03 | 10.14 | 231 | 213484 | 159603 | 70555126 |
Hypokalaemia | 79.45 | 10.14 | 173 | 213542 | 131015 | 70583714 |
Ascites | 79.27 | 10.14 | 53 | 213662 | 67494 | 70647235 |
Cardio-respiratory arrest | 78.85 | 10.14 | 113 | 213602 | 100564 | 70614165 |
Respiration abnormal | 78.29 | 10.14 | 100 | 213615 | 6764 | 70707965 |
Sleep disorder | 77.95 | 10.14 | 416 | 213299 | 69456 | 70645273 |
Right atrial hypertrophy | 77.77 | 10.14 | 38 | 213677 | 592 | 70714137 |
Cystic fibrosis | 77.08 | 10.14 | 79 | 213636 | 4202 | 70710527 |
Depressed level of consciousness | 76.85 | 10.14 | 90 | 213625 | 87341 | 70627388 |
Neurotoxicity | 76.69 | 10.14 | 3 | 213712 | 29823 | 70684906 |
Migraine | 76.48 | 10.14 | 424 | 213291 | 71814 | 70642915 |
Rhonchi | 76.09 | 10.14 | 73 | 213642 | 3582 | 70711147 |
Throat irritation | 75.25 | 10.14 | 256 | 213459 | 35048 | 70679681 |
Nasal discharge discolouration | 75.09 | 10.14 | 57 | 213658 | 2024 | 70712705 |
Abnormal dreams | 74.78 | 10.14 | 123 | 213592 | 10480 | 70704249 |
Lower respiratory tract infection | 74.09 | 10.14 | 584 | 213131 | 111329 | 70603400 |
Educational problem | 73.83 | 10.14 | 32 | 213683 | 372 | 70714357 |
Gastrointestinal haemorrhage | 73.07 | 10.14 | 194 | 213521 | 137214 | 70577515 |
Smoke sensitivity | 70.21 | 10.14 | 34 | 213681 | 519 | 70714210 |
Dehydration | 69.58 | 10.14 | 398 | 213317 | 225744 | 70488985 |
Throat tightness | 69.58 | 10.14 | 199 | 213516 | 24823 | 70689906 |
Rash erythematous | 66.87 | 10.14 | 321 | 213394 | 51397 | 70663332 |
Depressed mood | 66.38 | 10.14 | 285 | 213430 | 43535 | 70671194 |
Alopecia | 64.52 | 10.14 | 343 | 213372 | 198147 | 70516582 |
Feeling abnormal | 64.35 | 10.14 | 684 | 213031 | 141635 | 70573094 |
White blood cell count decreased | 63.43 | 10.14 | 280 | 213435 | 169861 | 70544868 |
Obstruction | 63.41 | 10.14 | 66 | 213649 | 3575 | 70711154 |
Frustration tolerance decreased | 62.57 | 10.14 | 89 | 213626 | 6676 | 70708053 |
Eosinophilic pneumonia chronic | 62.06 | 10.14 | 30 | 213685 | 456 | 70714273 |
Nasal turbinate hypertrophy | 61.22 | 10.14 | 32 | 213683 | 579 | 70714150 |
Neoplasm progression | 60.90 | 10.14 | 30 | 213685 | 45198 | 70669531 |
Dysplastic naevus | 60.82 | 10.14 | 31 | 213684 | 531 | 70714198 |
Bronchial disorder | 60.69 | 10.14 | 53 | 213662 | 2301 | 70712428 |
Cytomegalovirus infection | 60.53 | 10.14 | 22 | 213693 | 39736 | 70674993 |
Alanine aminotransferase increased | 60.40 | 10.14 | 234 | 213481 | 147246 | 70567483 |
Lactic acidosis | 60.36 | 10.14 | 64 | 213651 | 64960 | 70649769 |
Sopor | 59.60 | 10.14 | 11 | 213704 | 31256 | 70683473 |
Dyspnoea at rest | 59.12 | 10.14 | 87 | 213628 | 6732 | 70707997 |
Anosmia | 58.65 | 10.14 | 73 | 213642 | 4810 | 70709919 |
Agranulocytosis | 58.54 | 10.14 | 24 | 213691 | 40274 | 70674455 |
Acute myocardial infarction | 57.87 | 10.14 | 81 | 213634 | 72806 | 70641923 |
Tic | 57.68 | 10.14 | 55 | 213660 | 2678 | 70712051 |
Mast cell activation syndrome | 57.53 | 10.14 | 31 | 213684 | 598 | 70714131 |
Encephalopathy | 56.89 | 10.14 | 61 | 213654 | 61600 | 70653129 |
Musculoskeletal stiffness | 56.40 | 10.14 | 241 | 213474 | 147519 | 70567210 |
Decreased appetite | 56.17 | 10.14 | 617 | 213098 | 304163 | 70410566 |
Rhinitis perennial | 55.68 | 10.14 | 25 | 213690 | 318 | 70714411 |
Idiopathic intracranial hypertension | 55.55 | 10.14 | 55 | 213660 | 2806 | 70711923 |
Hepatic failure | 55.44 | 10.14 | 55 | 213660 | 57570 | 70657159 |
Ear infection | 54.80 | 10.14 | 199 | 213516 | 28137 | 70686592 |
Maternal exposure during pregnancy | 54.63 | 10.14 | 172 | 213543 | 115173 | 70599556 |
Hepatocellular injury | 54.30 | 10.14 | 36 | 213679 | 46055 | 70668674 |
Total lung capacity decreased | 54.15 | 10.14 | 46 | 213669 | 1923 | 70712806 |
Sinusitis fungal | 53.87 | 10.14 | 47 | 213668 | 2038 | 70712691 |
Bronchial neoplasm | 53.69 | 10.14 | 27 | 213688 | 449 | 70714280 |
Emphysema | 53.28 | 10.14 | 131 | 213584 | 14929 | 70699800 |
Acute myeloid leukaemia | 52.70 | 10.14 | 14 | 213701 | 30926 | 70683803 |
Delirium | 52.47 | 10.14 | 90 | 213625 | 74524 | 70640205 |
Sleep disorder due to general medical condition, insomnia type | 52.36 | 10.14 | 21 | 213694 | 35711 | 70679018 |
Bursitis | 52.16 | 10.14 | 188 | 213527 | 26485 | 70688244 |
Prolonged expiration | 51.63 | 10.14 | 34 | 213681 | 959 | 70713770 |
Nasal inflammation | 51.33 | 10.14 | 29 | 213686 | 616 | 70714113 |
Body temperature decreased | 50.99 | 10.14 | 196 | 213519 | 28476 | 70686253 |
Serotonin syndrome | 50.83 | 10.14 | 32 | 213683 | 42082 | 70672647 |
Screaming | 50.83 | 10.14 | 59 | 213656 | 3613 | 70711116 |
Therapy non-responder | 50.31 | 10.14 | 97 | 213618 | 76818 | 70637911 |
Psychomotor hyperactivity | 50.17 | 10.14 | 130 | 213585 | 15303 | 70699426 |
Neuroleptic malignant syndrome | 49.90 | 10.14 | 9 | 213706 | 25998 | 70688731 |
Hyper IgE syndrome | 49.71 | 10.14 | 26 | 213689 | 471 | 70714258 |
Hepatotoxicity | 49.64 | 10.14 | 36 | 213679 | 43950 | 70670779 |
Hypoglycaemia | 49.58 | 10.14 | 134 | 213581 | 94230 | 70620499 |
Palmar-plantar erythrodysaesthesia syndrome | 49.09 | 10.14 | 15 | 213700 | 30232 | 70684497 |
Neutropenic sepsis | 48.94 | 10.14 | 8 | 213707 | 24822 | 70689907 |
Swelling face | 48.82 | 10.14 | 342 | 213373 | 62822 | 70651907 |
Right ventricular hypertrophy | 48.80 | 10.14 | 38 | 213677 | 1402 | 70713327 |
Scratch | 48.65 | 10.14 | 82 | 213633 | 7128 | 70707601 |
Humidity intolerance | 48.58 | 10.14 | 23 | 213692 | 333 | 70714396 |
Victim of child abuse | 48.49 | 10.14 | 32 | 213683 | 906 | 70713823 |
Photodermatosis | 48.33 | 10.14 | 32 | 213683 | 911 | 70713818 |
Poor quality sleep | 48.24 | 10.14 | 153 | 213562 | 20196 | 70694533 |
Angioedema | 47.64 | 10.14 | 354 | 213361 | 66256 | 70648473 |
Acute respiratory distress syndrome | 47.56 | 10.14 | 33 | 213682 | 41221 | 70673508 |
Nasal obstruction | 47.42 | 10.14 | 39 | 213676 | 1558 | 70713171 |
Solar lentigo | 47.32 | 10.14 | 33 | 213682 | 1025 | 70713704 |
Blister | 46.84 | 10.14 | 151 | 213564 | 100375 | 70614354 |
Blood creatine phosphokinase increased | 46.75 | 10.14 | 70 | 213645 | 61193 | 70653536 |
Liver disorder | 46.35 | 10.14 | 71 | 213644 | 61497 | 70653232 |
Stress | 46.25 | 10.14 | 357 | 213358 | 67609 | 70647120 |
Blood bilirubin increased | 46.14 | 10.14 | 68 | 213647 | 59833 | 70654896 |
Aspartate aminotransferase increased | 46.10 | 10.14 | 211 | 213504 | 126767 | 70587962 |
Salpingo-oophorectomy unilateral | 45.99 | 10.14 | 27 | 213688 | 618 | 70714111 |
Red blood cell sedimentation rate increased | 45.77 | 10.14 | 30 | 213685 | 38612 | 70676117 |
Disseminated intravascular coagulation | 45.67 | 10.14 | 22 | 213693 | 33576 | 70681153 |
International normalised ratio increased | 45.20 | 10.14 | 111 | 213604 | 80615 | 70634114 |
Toxic epidermal necrolysis | 45.13 | 10.14 | 32 | 213683 | 39525 | 70675204 |
Drug resistance | 44.76 | 10.14 | 30 | 213685 | 38160 | 70676569 |
Skin plaque | 44.50 | 10.14 | 94 | 213621 | 9689 | 70705040 |
Mononeuropathy multiplex | 44.34 | 10.14 | 22 | 213693 | 355 | 70714374 |
Social avoidant behaviour | 44.17 | 10.14 | 62 | 213653 | 4594 | 70710135 |
Hepatic enzyme increased | 43.71 | 10.14 | 285 | 213430 | 156705 | 70558024 |
Cholestasis | 43.45 | 10.14 | 48 | 213667 | 47824 | 70666905 |
Liver injury | 43.24 | 10.14 | 36 | 213679 | 40999 | 70673730 |
Mastocytosis | 42.90 | 10.14 | 23 | 213692 | 439 | 70714290 |
Neutrophil count decreased | 42.88 | 10.14 | 120 | 213595 | 83436 | 70631293 |
Melaena | 42.41 | 10.14 | 65 | 213650 | 56290 | 70658439 |
Pneumonia aspiration | 42.11 | 10.14 | 77 | 213638 | 62212 | 70652517 |
Cardiogenic shock | 41.91 | 10.14 | 29 | 213686 | 36278 | 70678451 |
Product substitution issue | 41.90 | 10.14 | 137 | 213578 | 18376 | 70696353 |
Pulmonary mass | 41.51 | 10.14 | 172 | 213543 | 25861 | 70688868 |
Sedation | 41.17 | 10.14 | 48 | 213667 | 46683 | 70668046 |
Viral infection | 41.07 | 10.14 | 226 | 213489 | 38165 | 70676564 |
Myocardial infarction | 40.82 | 10.14 | 326 | 213389 | 171319 | 70543410 |
Metastases to bone | 40.31 | 10.14 | 9 | 213706 | 22367 | 70692362 |
Rash maculo-papular | 40.29 | 10.14 | 56 | 213659 | 50489 | 70664240 |
Hypomagnesaemia | 40.26 | 10.14 | 38 | 213677 | 40726 | 70674003 |
Carpal tunnel syndrome | 40.21 | 10.14 | 128 | 213587 | 16929 | 70697800 |
Negative thoughts | 40.15 | 10.14 | 33 | 213682 | 1317 | 70713412 |
Circulatory collapse | 40.07 | 10.14 | 29 | 213686 | 35445 | 70679284 |
Eye swelling | 40.02 | 10.14 | 159 | 213556 | 23455 | 70691274 |
Metastases to liver | 39.94 | 10.14 | 14 | 213701 | 25864 | 70688865 |
Pleural effusion | 39.68 | 10.14 | 236 | 213479 | 132628 | 70582101 |
Drug level increased | 39.67 | 10.14 | 31 | 213684 | 36438 | 70678291 |
Endometrial ablation | 39.45 | 10.14 | 27 | 213688 | 813 | 70713916 |
Burning sensation | 38.96 | 10.14 | 283 | 213432 | 52587 | 70662142 |
Nasal disorder | 38.93 | 10.14 | 49 | 213666 | 3265 | 70711464 |
Aphonia | 38.77 | 10.14 | 86 | 213629 | 9165 | 70705564 |
Nervousness | 38.68 | 10.14 | 191 | 213524 | 30929 | 70683800 |
Lower respiratory tract congestion | 38.58 | 10.14 | 49 | 213666 | 3295 | 70711434 |
Atopy | 38.38 | 10.14 | 19 | 213696 | 305 | 70714424 |
Lacrimation increased | 37.85 | 10.14 | 139 | 213576 | 19760 | 70694969 |
Eosinophil count | 37.78 | 10.14 | 14 | 213701 | 104 | 70714625 |
Nephrectomy | 37.51 | 10.14 | 36 | 213679 | 1767 | 70712962 |
Body tinea | 37.40 | 10.14 | 32 | 213683 | 1351 | 70713378 |
Anuria | 37.28 | 10.14 | 7 | 213708 | 19646 | 70695083 |
Suffocation feeling | 37.17 | 10.14 | 34 | 213681 | 1570 | 70713159 |
Ear pruritus | 37.04 | 10.14 | 46 | 213669 | 3024 | 70711705 |
Eosinophilic bronchitis | 36.74 | 10.14 | 20 | 213695 | 394 | 70714335 |
Abdominal discomfort | 36.61 | 10.14 | 442 | 213273 | 214216 | 70500513 |
Colitis | 36.31 | 10.14 | 87 | 213628 | 63727 | 70651002 |
Interstitial lung disease | 36.21 | 10.14 | 177 | 213538 | 104508 | 70610221 |
Cerebral haemorrhage | 36.04 | 10.14 | 67 | 213648 | 53797 | 70660932 |
Haemodynamic instability | 35.92 | 10.14 | 3 | 213712 | 15655 | 70699074 |
Skin ulcer | 35.78 | 10.14 | 56 | 213659 | 48089 | 70666640 |
Hypereosinophilic syndrome | 35.57 | 10.14 | 21 | 213694 | 486 | 70714243 |
Personality change | 35.55 | 10.14 | 81 | 213634 | 8789 | 70705940 |
Separation anxiety disorder | 35.35 | 10.14 | 10 | 213705 | 26 | 70714703 |
Product use in unapproved indication | 35.20 | 10.14 | 846 | 212869 | 206632 | 70508097 |
Haemophagocytic lymphohistiocytosis | 35.10 | 10.14 | 8 | 213707 | 19604 | 70695125 |
Pneumocystis jirovecii pneumonia | 34.76 | 10.14 | 24 | 213691 | 30058 | 70684671 |
Hepatic function abnormal | 34.64 | 10.14 | 98 | 213617 | 67898 | 70646831 |
Lipohypertrophy | 34.55 | 10.14 | 25 | 213690 | 824 | 70713905 |
Blood urea increased | 34.50 | 10.14 | 53 | 213662 | 45856 | 70668873 |
Diastolic dysfunction | 34.38 | 10.14 | 83 | 213632 | 9350 | 70705379 |
Rheumatoid nodule | 34.25 | 10.14 | 3 | 213712 | 15064 | 70699665 |
Ear discomfort | 34.18 | 10.14 | 73 | 213642 | 7581 | 70707148 |
Affective disorder | 34.18 | 10.14 | 72 | 213643 | 7407 | 70707322 |
Biliary dyskinesia | 33.97 | 10.14 | 39 | 213676 | 2360 | 70712369 |
Transplant rejection | 33.36 | 10.14 | 7 | 213708 | 18164 | 70696565 |
Blood pressure fluctuation | 33.14 | 10.14 | 81 | 213634 | 58931 | 70655798 |
Somnambulism | 33.10 | 10.14 | 58 | 213657 | 5202 | 70709527 |
Weight decreased | 32.96 | 10.14 | 1194 | 212521 | 309294 | 70405435 |
Chest X-ray abnormal | 32.91 | 10.14 | 69 | 213646 | 7075 | 70707654 |
Increased viscosity of bronchial secretion | 32.86 | 10.14 | 20 | 213695 | 490 | 70714239 |
Blood cholesterol | 32.76 | 10.14 | 21 | 213694 | 565 | 70714164 |
Plasma cell myeloma | 32.69 | 10.14 | 112 | 213603 | 73089 | 70641640 |
Electrocardiogram QT prolonged | 32.61 | 10.14 | 135 | 213580 | 83382 | 70631347 |
Cholecystitis chronic | 32.58 | 10.14 | 81 | 213634 | 9295 | 70705434 |
Irritable bowel syndrome | 32.50 | 10.14 | 65 | 213650 | 50785 | 70663944 |
Heart sounds | 32.49 | 10.14 | 23 | 213692 | 732 | 70713997 |
Temperature intolerance | 32.05 | 10.14 | 77 | 213638 | 8646 | 70706083 |
Bone erosion | 31.98 | 10.14 | 4 | 213711 | 15169 | 70699560 |
Bronchial haemorrhage | 31.61 | 10.14 | 28 | 213687 | 1239 | 70713490 |
Sinus polyp | 31.60 | 10.14 | 19 | 213696 | 455 | 70714274 |
Erythema | 31.55 | 10.14 | 806 | 212909 | 198757 | 70515972 |
Overdose | 31.49 | 10.14 | 343 | 213372 | 169402 | 70545327 |
Creatinine renal clearance decreased | 30.82 | 10.14 | 7 | 213708 | 17193 | 70697536 |
Eosinophilic oesophagitis | 30.74 | 10.14 | 19 | 213696 | 479 | 70714250 |
Cytokine release syndrome | 30.74 | 10.14 | 21 | 213694 | 26446 | 70688283 |
Extrapyramidal disorder | 30.72 | 10.14 | 12 | 213703 | 20738 | 70693991 |
Haemoptysis | 30.54 | 10.14 | 262 | 213453 | 51190 | 70663539 |
Poisoning | 30.46 | 10.14 | 15 | 213700 | 22607 | 70692122 |
Respiratory tract inflammation | 30.41 | 10.14 | 23 | 213692 | 812 | 70713917 |
Respiratory tract irritation | 30.34 | 10.14 | 20 | 213695 | 565 | 70714164 |
Hyperbilirubinaemia | 30.34 | 10.14 | 15 | 213700 | 22553 | 70692176 |
Altered state of consciousness | 30.27 | 10.14 | 46 | 213669 | 39976 | 70674753 |
Morbid thoughts | 30.17 | 10.14 | 22 | 213693 | 734 | 70713995 |
Quality of life decreased | 30.16 | 10.14 | 74 | 213641 | 8421 | 70706308 |
Pharyngitis streptococcal | 30.11 | 10.14 | 79 | 213636 | 9369 | 70705360 |
Osteoporosis | 30.06 | 10.14 | 251 | 213464 | 48656 | 70666073 |
Airway remodelling | 30.05 | 10.14 | 14 | 213701 | 195 | 70714534 |
Panic attack | 29.83 | 10.14 | 139 | 213576 | 21980 | 70692749 |
Urticaria chronic | 29.81 | 10.14 | 19 | 213696 | 506 | 70714223 |
Acute hepatic failure | 29.50 | 10.14 | 24 | 213691 | 27648 | 70687081 |
Swollen tongue | 29.46 | 10.14 | 202 | 213513 | 36844 | 70677885 |
Spirometry abnormal | 29.45 | 10.14 | 21 | 213694 | 676 | 70714053 |
Sputum culture positive | 29.38 | 10.14 | 43 | 213672 | 3311 | 70711418 |
Forced expiratory flow decreased | 29.37 | 10.14 | 15 | 213700 | 258 | 70714471 |
Palpitations | 29.35 | 10.14 | 483 | 213232 | 110270 | 70604459 |
Pharyngeal swelling | 29.34 | 10.14 | 62 | 213653 | 6391 | 70708338 |
Polyp | 29.32 | 10.14 | 66 | 213649 | 7104 | 70707625 |
Hepatic encephalopathy | 29.28 | 10.14 | 15 | 213700 | 22103 | 70692626 |
Drug reaction with eosinophilia and systemic symptoms | 29.26 | 10.14 | 84 | 213631 | 57929 | 70656800 |
Osteonecrosis of jaw | 29.24 | 10.14 | 49 | 213666 | 40953 | 70673776 |
Cardiac murmur | 29.23 | 10.14 | 92 | 213623 | 12094 | 70702635 |
Cytopenia | 29.20 | 10.14 | 8 | 213707 | 17315 | 70697414 |
Intentional product misuse | 29.04 | 10.14 | 132 | 213583 | 79463 | 70635266 |
Infection susceptibility increased | 28.98 | 10.14 | 40 | 213675 | 2917 | 70711812 |
Ischaemic stroke | 28.98 | 10.14 | 30 | 213685 | 30790 | 70683939 |
Neuropathy peripheral | 28.80 | 10.14 | 244 | 213471 | 126652 | 70588077 |
Unresponsive to stimuli | 28.60 | 10.14 | 72 | 213643 | 51859 | 70662870 |
Nephropathy toxic | 28.60 | 10.14 | 10 | 213705 | 18504 | 70696225 |
Inflammation | 28.37 | 10.14 | 131 | 213584 | 78534 | 70636195 |
Hereditary angioedema | 28.29 | 10.14 | 53 | 213662 | 5006 | 70709723 |
Fear | 28.23 | 10.14 | 131 | 213584 | 20680 | 70694049 |
FEV1/FVC ratio decreased | 28.10 | 10.14 | 13 | 213702 | 178 | 70714551 |
Total lung capacity abnormal | 28.10 | 10.14 | 13 | 213702 | 178 | 70714551 |
Lung diffusion test decreased | 28.09 | 10.14 | 26 | 213689 | 1219 | 70713510 |
Type 2 diabetes mellitus | 28.04 | 10.14 | 228 | 213487 | 43852 | 70670877 |
Accidental overdose | 27.90 | 10.14 | 39 | 213676 | 35082 | 70679647 |
Nocturnal fear | 27.90 | 10.14 | 7 | 213708 | 9 | 70714720 |
Sinus operation | 27.63 | 10.14 | 32 | 213683 | 1955 | 70712774 |
Increased bronchial secretion | 27.59 | 10.14 | 40 | 213675 | 3053 | 70711676 |
Mite allergy | 27.58 | 10.14 | 22 | 213693 | 841 | 70713888 |
Lymphocyte count decreased | 27.53 | 10.14 | 56 | 213659 | 43483 | 70671246 |
Clostridium difficile colitis | 27.51 | 10.14 | 28 | 213687 | 28968 | 70685761 |
Gamma-glutamyltransferase increased | 27.36 | 10.14 | 71 | 213644 | 50614 | 70664115 |
Influenza like illness | 27.21 | 10.14 | 309 | 213406 | 65022 | 70649707 |
Hysterectomy | 26.78 | 10.14 | 55 | 213660 | 5557 | 70709172 |
Haematochezia | 26.78 | 10.14 | 121 | 213594 | 72960 | 70641769 |
Self-injurious ideation | 26.67 | 10.14 | 41 | 213674 | 3297 | 70711432 |
Cerebral infarction | 26.62 | 10.14 | 56 | 213659 | 42953 | 70671776 |
Gastrointestinal disorder | 26.57 | 10.14 | 197 | 213518 | 105230 | 70609499 |
Hypercalcaemia | 26.51 | 10.14 | 39 | 213676 | 34346 | 70680383 |
Fluid retention | 26.49 | 10.14 | 300 | 213415 | 63085 | 70651644 |
Condition aggravated | 26.47 | 10.14 | 1037 | 212678 | 426598 | 70288131 |
Infusion site swelling | 26.41 | 10.14 | 58 | 213657 | 6140 | 70708589 |
Prostate cancer | 26.40 | 10.14 | 33 | 213682 | 31130 | 70683599 |
Infusion site pruritus | 26.21 | 10.14 | 40 | 213675 | 3197 | 70711532 |
Forced expiratory volume abnormal | 26.16 | 10.14 | 11 | 213704 | 118 | 70714611 |
Eye disorder | 26.14 | 10.14 | 128 | 213587 | 20657 | 70694072 |
Neurosensory hypoacusis | 26.13 | 10.14 | 13 | 213702 | 211 | 70714518 |
Renal tubular necrosis | 26.10 | 10.14 | 19 | 213696 | 23152 | 70691577 |
Proteinuria | 26.06 | 10.14 | 30 | 213685 | 29344 | 70685385 |
Diabetic ketoacidosis | 26.04 | 10.14 | 34 | 213681 | 31478 | 70683251 |
Orthostatic hypotension | 26.04 | 10.14 | 75 | 213640 | 51668 | 70663061 |
Vomiting | 26.04 | 10.14 | 1492 | 212223 | 591619 | 70123110 |
Tubulointerstitial nephritis | 26.01 | 10.14 | 37 | 213678 | 33039 | 70681690 |
Lung disorder | 26.01 | 10.14 | 322 | 213393 | 69162 | 70645567 |
Bacteraemia | 25.93 | 10.14 | 30 | 213685 | 29279 | 70685450 |
Haematemesis | 25.84 | 10.14 | 69 | 213646 | 48728 | 70666001 |
Respiratory arrest | 25.83 | 10.14 | 80 | 213635 | 53853 | 70660876 |
Progressive multifocal leukoencephalopathy | 25.48 | 10.14 | 13 | 213702 | 19201 | 70695528 |
Metastases to lung | 25.30 | 10.14 | 9 | 213706 | 16475 | 70698254 |
Status epilepticus | 25.25 | 10.14 | 22 | 213693 | 24504 | 70690225 |
Weight increased | 25.24 | 10.14 | 930 | 212785 | 241401 | 70473328 |
Nausea | 25.23 | 10.14 | 2218 | 211497 | 849870 | 69864859 |
Peritonitis | 25.12 | 10.14 | 25 | 213690 | 26134 | 70688595 |
COVID-19 | 25.05 | 10.14 | 453 | 213262 | 105304 | 70609425 |
Enuresis | 24.98 | 10.14 | 37 | 213678 | 2880 | 70711849 |
Lip swelling | 24.93 | 10.14 | 182 | 213533 | 33872 | 70680857 |
Obsessive-compulsive disorder | 24.89 | 10.14 | 52 | 213663 | 5318 | 70709411 |
Hypocalcaemia | 24.86 | 10.14 | 62 | 213653 | 44797 | 70669932 |
Skin necrosis | 24.82 | 10.14 | 9 | 213706 | 16282 | 70698447 |
Atrioventricular block first degree | 24.79 | 10.14 | 3 | 213712 | 11670 | 70703059 |
Cognitive disorder | 24.76 | 10.14 | 97 | 213618 | 60859 | 70653870 |
Myelodysplastic syndrome | 24.75 | 10.14 | 32 | 213683 | 29753 | 70684976 |
Colitis ulcerative | 24.70 | 10.14 | 40 | 213675 | 33883 | 70680846 |
Stevens-Johnson syndrome | 24.61 | 10.14 | 44 | 213671 | 35863 | 70678866 |
Sinus bradycardia | 24.55 | 10.14 | 21 | 213694 | 23602 | 70691127 |
Snoring | 24.52 | 10.14 | 49 | 213666 | 4855 | 70709874 |
Eosinophilic pneumonia | 24.51 | 10.14 | 49 | 213666 | 4856 | 70709873 |
Shock haemorrhagic | 24.39 | 10.14 | 12 | 213703 | 18094 | 70696635 |
Attention deficit hyperactivity disorder | 24.31 | 10.14 | 37 | 213678 | 2950 | 70711779 |
Cardiac disorder | 24.28 | 10.14 | 280 | 213435 | 59135 | 70655594 |
Haemodialysis | 24.17 | 10.14 | 11 | 213704 | 17355 | 70697374 |
Asthenia | 24.12 | 10.14 | 1130 | 212585 | 456536 | 70258193 |
Haematuria | 24.05 | 10.14 | 104 | 213611 | 63469 | 70651260 |
Incorrect dose administered | 24.04 | 10.14 | 307 | 213408 | 66412 | 70648317 |
Live birth | 23.91 | 10.14 | 6 | 213709 | 13773 | 70700956 |
Attention-seeking behaviour | 23.89 | 10.14 | 10 | 213705 | 106 | 70714623 |
Immune reconstitution inflammatory syndrome | 23.85 | 10.14 | 5 | 213710 | 12985 | 70701744 |
Inappropriate schedule of product administration | 23.85 | 10.14 | 456 | 213259 | 107099 | 70607630 |
Oropharyngeal discomfort | 23.79 | 10.14 | 55 | 213660 | 6024 | 70708705 |
Neurodevelopmental disorder | 23.77 | 10.14 | 8 | 213707 | 43 | 70714686 |
Jaundice | 23.52 | 10.14 | 75 | 213640 | 50033 | 70664696 |
Blebitis | 23.38 | 10.14 | 6 | 213709 | 9 | 70714720 |
Asthma exercise induced | 23.32 | 10.14 | 10 | 213705 | 113 | 70714616 |
Injection site scab | 23.22 | 10.14 | 14 | 213701 | 337 | 70714392 |
Pulmonary pain | 22.86 | 10.14 | 39 | 213676 | 3423 | 70711306 |
Homicidal ideation | 22.70 | 10.14 | 38 | 213677 | 3285 | 70711444 |
Pneumothorax spontaneous | 22.62 | 10.14 | 24 | 213691 | 1329 | 70713400 |
Atrial fibrillation | 22.57 | 10.14 | 405 | 213310 | 183943 | 70530786 |
Allergy test positive | 22.53 | 10.14 | 15 | 213700 | 431 | 70714298 |
Haemorrhage intracranial | 22.31 | 10.14 | 25 | 213690 | 24752 | 70689977 |
Suicidal behaviour | 22.29 | 10.14 | 36 | 213679 | 3020 | 70711709 |
Upper limb fracture | 22.26 | 10.14 | 102 | 213613 | 16017 | 70698712 |
Lymphopenia | 22.12 | 10.14 | 30 | 213685 | 27329 | 70687400 |
Cortisol decreased | 22.09 | 10.14 | 28 | 213687 | 1879 | 70712850 |
NPM1 gene mutation | 22.08 | 10.14 | 10 | 213705 | 130 | 70714599 |
Thinking abnormal | 21.93 | 10.14 | 83 | 213632 | 11968 | 70702761 |
Swelling | 21.90 | 10.14 | 418 | 213297 | 188121 | 70526608 |
Injection site pruritus | 21.89 | 10.14 | 197 | 213518 | 39013 | 70675716 |
Exposure to allergen | 21.79 | 10.14 | 12 | 213703 | 242 | 70714487 |
Appetite disorder | 21.79 | 10.14 | 58 | 213657 | 6937 | 70707792 |
Oesophageal polyp | 21.76 | 10.14 | 8 | 213707 | 58 | 70714671 |
Dysarthria | 21.75 | 10.14 | 105 | 213610 | 62208 | 70652521 |
Ejection fraction decreased | 21.72 | 10.14 | 37 | 213678 | 30725 | 70684004 |
Drug-induced liver injury | 21.72 | 10.14 | 91 | 213624 | 56022 | 70658707 |
Ligament pain | 21.66 | 10.14 | 12 | 213703 | 245 | 70714484 |
Epidural lipomatosis | 21.62 | 10.14 | 20 | 213695 | 937 | 70713792 |
Joint range of motion decreased | 21.59 | 10.14 | 28 | 213687 | 25998 | 70688731 |
Emotional disorder | 21.57 | 10.14 | 88 | 213627 | 13138 | 70701591 |
Posterior reversible encephalopathy syndrome | 21.56 | 10.14 | 25 | 213690 | 24377 | 70690352 |
Torsade de pointes | 21.54 | 10.14 | 14 | 213701 | 18102 | 70696627 |
Endocarditis fibroplastica | 21.38 | 10.14 | 6 | 213709 | 15 | 70714714 |
Blood alkaline phosphatase increased | 21.37 | 10.14 | 97 | 213618 | 58424 | 70656305 |
Choking sensation | 21.33 | 10.14 | 39 | 213676 | 3616 | 70711113 |
Febrile bone marrow aplasia | 21.24 | 10.14 | 5 | 213710 | 11986 | 70702743 |
Electrolyte imbalance | 21.17 | 10.14 | 30 | 213685 | 26831 | 70687898 |
Miosis | 21.13 | 10.14 | 8 | 213707 | 14093 | 70700636 |
Hypoalbuminaemia | 21.12 | 10.14 | 16 | 213699 | 19106 | 70695623 |
Ulcer | 21.06 | 10.14 | 28 | 213687 | 25726 | 70689003 |
Urinary retention | 21.06 | 10.14 | 84 | 213631 | 52436 | 70662293 |
Acute generalised exanthematous pustulosis | 21.05 | 10.14 | 10 | 213705 | 15387 | 70699342 |
Pulmonary renal syndrome | 21.03 | 10.14 | 16 | 213699 | 570 | 70714159 |
Chest pain | 21.02 | 10.14 | 942 | 212773 | 250318 | 70464411 |
Ocular discomfort | 21.01 | 10.14 | 43 | 213672 | 4334 | 70710395 |
Injection site pain | 20.97 | 10.14 | 483 | 213232 | 117136 | 70597593 |
Subarachnoid haemorrhage | 20.69 | 10.14 | 17 | 213698 | 19487 | 70695242 |
Increased upper airway secretion | 20.65 | 10.14 | 39 | 213676 | 3706 | 70711023 |
Female genital tract fistula | 20.55 | 10.14 | 35 | 213680 | 3068 | 70711661 |
Nasal discomfort | 20.54 | 10.14 | 45 | 213670 | 4756 | 70709973 |
Atrioventricular block complete | 20.50 | 10.14 | 10 | 213705 | 15153 | 70699576 |
Blood immunoglobulin G decreased | 20.49 | 10.14 | 34 | 213681 | 2918 | 70711811 |
Nasal mucosal disorder | 20.41 | 10.14 | 13 | 213702 | 346 | 70714383 |
Myoclonus | 20.21 | 10.14 | 30 | 213685 | 26325 | 70688404 |
Inhibitory drug interaction | 20.20 | 10.14 | 39 | 213676 | 3768 | 70710961 |
Metastases to central nervous system | 20.20 | 10.14 | 10 | 213705 | 15024 | 70699705 |
Pulmonary arterial hypertension | 20.15 | 10.14 | 43 | 213672 | 32812 | 70681917 |
Mental disorder | 20.14 | 10.14 | 150 | 213565 | 28090 | 70686639 |
Coagulopathy | 19.99 | 10.14 | 44 | 213671 | 33205 | 70681524 |
Hyposmia | 19.98 | 10.14 | 16 | 213699 | 615 | 70714114 |
Neuropsychiatric symptoms | 19.95 | 10.14 | 20 | 213695 | 1036 | 70713693 |
Schizophrenia | 19.88 | 10.14 | 13 | 213702 | 16755 | 70697974 |
Venoocclusive liver disease | 19.84 | 10.14 | 4 | 213711 | 10674 | 70704055 |
Drug tolerance decreased | 19.76 | 10.14 | 3 | 213712 | 9830 | 70704899 |
Electrocardiogram QRS complex prolonged | 19.69 | 10.14 | 3 | 213712 | 9803 | 70704926 |
Hepatitis C | 19.64 | 10.14 | 7 | 213708 | 12800 | 70701929 |
Chronic kidney disease | 19.54 | 10.14 | 106 | 213609 | 60951 | 70653778 |
Vasculitis | 19.50 | 10.14 | 113 | 213602 | 19445 | 70695284 |
Lactose intolerance | 19.39 | 10.14 | 28 | 213687 | 2130 | 70712599 |
Injection site movement impairment | 19.26 | 10.14 | 6 | 213709 | 24 | 70714705 |
Tenosynovitis | 19.23 | 10.14 | 9 | 213706 | 13967 | 70700762 |
Poisoning deliberate | 19.20 | 10.14 | 14 | 213701 | 17046 | 70697683 |
Sputum retention | 19.20 | 10.14 | 19 | 213696 | 969 | 70713760 |
Adrenal suppression | 19.18 | 10.14 | 22 | 213693 | 1330 | 70713399 |
Pathogen resistance | 19.14 | 10.14 | 8 | 213707 | 13271 | 70701458 |
Liver function test abnormal | 19.11 | 10.14 | 107 | 213608 | 61039 | 70653690 |
Ejection fraction abnormal | 19.04 | 10.14 | 25 | 213690 | 1738 | 70712991 |
Pigment dispersion syndrome | 18.88 | 10.14 | 6 | 213709 | 26 | 70714703 |
Emotional distress | 18.83 | 10.14 | 183 | 213532 | 37005 | 70677724 |
Oliguria | 18.77 | 10.14 | 11 | 213704 | 15040 | 70699689 |
Embolism venous | 18.73 | 10.14 | 38 | 213677 | 3807 | 70710922 |
Hip arthroplasty | 18.65 | 10.14 | 35 | 213680 | 28005 | 70686724 |
Prothrombin time prolonged | 18.59 | 10.14 | 13 | 213702 | 16177 | 70698552 |
Cytomegalovirus viraemia | 18.59 | 10.14 | 6 | 213709 | 11679 | 70703050 |
Hallucination | 18.54 | 10.14 | 328 | 213387 | 75932 | 70638797 |
Obesity | 18.42 | 10.14 | 141 | 213574 | 26630 | 70688099 |
CFTR gene mutation | 18.38 | 10.14 | 8 | 213707 | 94 | 70714635 |
Airway peak pressure increased | 18.36 | 10.14 | 12 | 213703 | 334 | 70714395 |
Sleep talking | 18.36 | 10.14 | 19 | 213696 | 1022 | 70713707 |
Encephalitis | 18.30 | 10.14 | 9 | 213706 | 13576 | 70701153 |
Intestinal perforation | 18.27 | 10.14 | 13 | 213702 | 16031 | 70698698 |
Subdural haematoma | 18.25 | 10.14 | 38 | 213677 | 29260 | 70685469 |
Upper airway obstruction | 18.23 | 10.14 | 21 | 213694 | 1275 | 70713454 |
Allergic sinusitis | 18.20 | 10.14 | 14 | 213701 | 507 | 70714222 |
Haemophilus infection | 18.17 | 10.14 | 26 | 213689 | 1961 | 70712768 |
Eye paraesthesia | 18.16 | 10.14 | 8 | 213707 | 97 | 70714632 |
Dysphemia | 18.02 | 10.14 | 34 | 213681 | 3229 | 70711500 |
Injection site hypoaesthesia | 17.98 | 10.14 | 13 | 213702 | 428 | 70714301 |
Pharyngeal oedema | 17.87 | 10.14 | 94 | 213621 | 15602 | 70699127 |
Sputum abnormal | 17.87 | 10.14 | 19 | 213696 | 1055 | 70713674 |
Panniculitis | 17.86 | 10.14 | 5 | 213710 | 10671 | 70704058 |
Lung hernia | 17.82 | 10.14 | 7 | 213708 | 62 | 70714667 |
Infection | 17.80 | 10.14 | 491 | 213224 | 210294 | 70504435 |
Intervertebral disc degeneration | 17.76 | 10.14 | 86 | 213629 | 13814 | 70700915 |
Transaminases increased | 17.73 | 10.14 | 77 | 213638 | 46941 | 70667788 |
Oxygen saturation decreased | 17.73 | 10.14 | 468 | 213247 | 115961 | 70598768 |
Fall | 17.71 | 10.14 | 1127 | 212588 | 442969 | 70271760 |
Muscle rigidity | 17.71 | 10.14 | 18 | 213697 | 18632 | 70696097 |
Hallucination, auditory | 17.70 | 10.14 | 105 | 213610 | 18223 | 70696506 |
Upper gastrointestinal haemorrhage | 17.65 | 10.14 | 56 | 213659 | 37421 | 70677308 |
Gluten sensitivity | 17.63 | 10.14 | 12 | 213703 | 358 | 70714371 |
Muscle spasticity | 17.58 | 10.14 | 20 | 213695 | 19669 | 70695060 |
Basal cell carcinoma | 17.58 | 10.14 | 48 | 213667 | 33650 | 70681079 |
Syncope | 17.56 | 10.14 | 373 | 213342 | 165336 | 70549393 |
Child abuse | 17.54 | 10.14 | 12 | 213703 | 361 | 70714368 |
Blood lactic acid | 17.41 | 10.14 | 13 | 213702 | 450 | 70714279 |
Paraesthesia oral | 17.33 | 10.14 | 92 | 213623 | 15325 | 70699404 |
Frequent bowel movements | 17.30 | 10.14 | 23 | 213692 | 21130 | 70693599 |
Shock | 17.28 | 10.14 | 63 | 213652 | 40362 | 70674367 |
Infusion site erythema | 17.26 | 10.14 | 56 | 213659 | 7479 | 70707250 |
Toxic encephalopathy | 17.18 | 10.14 | 5 | 213710 | 10401 | 70704328 |
Meningitis eosinophilic | 17.15 | 10.14 | 5 | 213710 | 15 | 70714714 |
Pulmonary artery stenosis congenital | 17.15 | 10.14 | 5 | 213710 | 15 | 70714714 |
Knee arthroplasty | 17.05 | 10.14 | 50 | 213665 | 34251 | 70680478 |
Sputum purulent | 17.03 | 10.14 | 20 | 213695 | 1240 | 70713489 |
Acidosis | 16.92 | 10.14 | 18 | 213697 | 18245 | 70696484 |
Glucose tolerance impaired | 16.89 | 10.14 | 52 | 213663 | 6754 | 70707975 |
Psoriatic arthropathy | 16.82 | 10.14 | 120 | 213595 | 64651 | 70650078 |
Tachycardia | 16.76 | 10.14 | 357 | 213358 | 158189 | 70556540 |
Urinary tract infection | 16.76 | 10.14 | 597 | 213118 | 248172 | 70466557 |
Ligament sprain | 16.74 | 10.14 | 76 | 213639 | 11887 | 70702842 |
Functional residual capacity increased | 16.74 | 10.14 | 7 | 213708 | 74 | 70714655 |
Brain oedema | 16.69 | 10.14 | 28 | 213687 | 23390 | 70691339 |
Blood potassium increased | 16.56 | 10.14 | 36 | 213679 | 27290 | 70687439 |
Glomerular filtration rate decreased | 16.54 | 10.14 | 23 | 213692 | 20733 | 70693996 |
Hypercapnia | 16.53 | 10.14 | 59 | 213656 | 8270 | 70706459 |
Medication error | 16.50 | 10.14 | 102 | 213613 | 56810 | 70657919 |
Hyperkaliuria | 16.50 | 10.14 | 9 | 213706 | 178 | 70714551 |
Toxic skin eruption | 16.41 | 10.14 | 22 | 213693 | 20140 | 70694589 |
Oesophageal carcinoma | 16.41 | 10.14 | 4 | 213711 | 9362 | 70705367 |
Ileus | 16.34 | 10.14 | 30 | 213685 | 24207 | 70690522 |
Injection site urticaria | 16.34 | 10.14 | 74 | 213641 | 11564 | 70703165 |
Pulmonary thrombosis | 16.28 | 10.14 | 72 | 213643 | 11136 | 70703593 |
Joint stiffness | 16.26 | 10.14 | 53 | 213662 | 35123 | 70679606 |
Allergic respiratory disease | 16.26 | 10.14 | 7 | 213708 | 80 | 70714649 |
Blood lactate dehydrogenase increased | 16.19 | 10.14 | 53 | 213662 | 35074 | 70679655 |
Ankle fracture | 16.19 | 10.14 | 90 | 213625 | 15254 | 70699475 |
Drug ineffective | 16.09 | 10.14 | 2537 | 211178 | 937215 | 69777514 |
Mobility decreased | 16.09 | 10.14 | 216 | 213499 | 102783 | 70611946 |
Endocarditis | 16.04 | 10.14 | 5 | 213710 | 9949 | 70704780 |
Panic reaction | 16.02 | 10.14 | 38 | 213677 | 4233 | 70710496 |
Splenomegaly | 15.96 | 10.14 | 20 | 213695 | 18850 | 70695879 |
Hospitalisation | 15.96 | 10.14 | 343 | 213372 | 82225 | 70632504 |
Seizure | 15.95 | 10.14 | 411 | 213304 | 177551 | 70537178 |
Blood calcium decreased | 15.88 | 10.14 | 40 | 213675 | 28806 | 70685923 |
Proctalgia | 15.87 | 10.14 | 3 | 213712 | 8380 | 70706349 |
Sarcoidosis | 15.87 | 10.14 | 50 | 213665 | 6577 | 70708152 |
Prescribed underdose | 15.77 | 10.14 | 25 | 213690 | 21360 | 70693369 |
Klebsiella infection | 15.73 | 10.14 | 12 | 213703 | 14280 | 70700449 |
Gangrene | 15.67 | 10.14 | 3 | 213712 | 8306 | 70706423 |
Hemiparesis | 15.55 | 10.14 | 46 | 213669 | 31423 | 70683306 |
Bronchiolitis obliterans syndrome | 15.44 | 10.14 | 10 | 213705 | 274 | 70714455 |
Mucosal discolouration | 15.37 | 10.14 | 15 | 213700 | 752 | 70713977 |
Product taste abnormal | 15.36 | 10.14 | 25 | 213690 | 2111 | 70712618 |
Pulmonary oedema | 15.35 | 10.14 | 166 | 213549 | 82112 | 70632617 |
Aortic valve stenosis | 15.33 | 10.14 | 41 | 213674 | 4918 | 70709811 |
Drug eruption | 15.31 | 10.14 | 64 | 213651 | 39432 | 70675297 |
Drug use disorder | 15.25 | 10.14 | 3 | 213712 | 8148 | 70706581 |
Hypohidrosis | 15.25 | 10.14 | 10 | 213705 | 280 | 70714449 |
Catatonia | 15.21 | 10.14 | 3 | 213712 | 8130 | 70706599 |
Rectal haemorrhage | 15.19 | 10.14 | 126 | 213589 | 65705 | 70649024 |
Chimerism | 15.19 | 10.14 | 10 | 213705 | 282 | 70714447 |
Depressive symptom | 15.18 | 10.14 | 42 | 213673 | 5139 | 70709590 |
Hepatic cirrhosis | 15.13 | 10.14 | 45 | 213670 | 30686 | 70684043 |
Enterococcal infection | 15.11 | 10.14 | 13 | 213702 | 14569 | 70700160 |
Breast neoplasm | 15.08 | 10.14 | 16 | 213699 | 886 | 70713843 |
Femur fracture | 14.99 | 10.14 | 57 | 213658 | 36075 | 70678654 |
Aplastic anaemia | 14.91 | 10.14 | 17 | 213698 | 16699 | 70698030 |
Peripheral sensory neuropathy | 14.89 | 10.14 | 9 | 213706 | 12101 | 70702628 |
Ileus paralytic | 14.85 | 10.14 | 4 | 213711 | 8757 | 70705972 |
Fracture pain | 14.83 | 10.14 | 11 | 213704 | 377 | 70714352 |
Respiratory failure | 14.78 | 10.14 | 391 | 213324 | 168344 | 70546385 |
Diaphragmatic disorder | 14.77 | 10.14 | 21 | 213694 | 1575 | 70713154 |
Hypertensive crisis | 14.70 | 10.14 | 22 | 213693 | 19240 | 70695489 |
Inappropriate antidiuretic hormone secretion | 14.66 | 10.14 | 30 | 213685 | 23246 | 70691483 |
Ataxia | 14.56 | 10.14 | 30 | 213685 | 23187 | 70691542 |
Adenotonsillectomy | 14.55 | 10.14 | 6 | 213709 | 61 | 70714668 |
Delusion | 14.52 | 10.14 | 22 | 213693 | 19143 | 70695586 |
Osteomyelitis | 14.49 | 10.14 | 45 | 213670 | 30273 | 70684456 |
Body temperature abnormal | 14.45 | 10.14 | 23 | 213692 | 1906 | 70712823 |
Pigmentary glaucoma | 14.42 | 10.14 | 3 | 213712 | 0 | 70714729 |
Sleep study abnormal | 14.42 | 10.14 | 3 | 213712 | 0 | 70714729 |
Benign prostatic hyperplasia | 14.36 | 10.14 | 66 | 213649 | 10377 | 70704352 |
Kidney transplant rejection | 14.36 | 10.14 | 6 | 213709 | 9955 | 70704774 |
Laryngospasm | 14.30 | 10.14 | 33 | 213682 | 3610 | 70711119 |
Gastric haemorrhage | 14.27 | 10.14 | 13 | 213702 | 14172 | 70700557 |
School refusal | 14.26 | 10.14 | 5 | 213710 | 31 | 70714698 |
Peak expiratory flow rate increased | 14.25 | 10.14 | 4 | 213711 | 10 | 70714719 |
Therapeutic response unexpected | 14.25 | 10.14 | 99 | 213616 | 18132 | 70696597 |
Gastroenteritis viral | 14.20 | 10.14 | 112 | 213603 | 21343 | 70693386 |
Bronchopulmonary aspergillosis | 14.16 | 10.14 | 26 | 213689 | 20976 | 70693753 |
Dialysis | 14.15 | 10.14 | 19 | 213696 | 17383 | 70697346 |
Nasal septum deviation | 14.14 | 10.14 | 21 | 213694 | 1638 | 70713091 |
Spinal operation | 14.14 | 10.14 | 50 | 213665 | 6978 | 70707751 |
Colorectal cancer | 14.11 | 10.14 | 4 | 213711 | 8466 | 70706263 |
Muscle tension dysphonia | 14.06 | 10.14 | 6 | 213709 | 67 | 70714662 |
Tachypnoea | 14.05 | 10.14 | 42 | 213673 | 28596 | 70686133 |
Vasomotor rhinitis | 13.99 | 10.14 | 7 | 213708 | 115 | 70714614 |
Pyrexia | 13.89 | 10.14 | 1609 | 212106 | 605343 | 70109386 |
Eosinophil count abnormal | 13.86 | 10.14 | 13 | 213702 | 620 | 70714109 |
Paranasal sinus discomfort | 13.85 | 10.14 | 32 | 213683 | 3503 | 70711226 |
Acute pulmonary oedema | 13.84 | 10.14 | 12 | 213703 | 13400 | 70701329 |
Cushingoid | 13.83 | 10.14 | 56 | 213659 | 8332 | 70706397 |
Growth retardation | 13.83 | 10.14 | 21 | 213694 | 1671 | 70713058 |
Bronchitis chronic | 13.78 | 10.14 | 35 | 213680 | 4069 | 70710660 |
Blood parathyroid hormone decreased | 13.72 | 10.14 | 5 | 213710 | 9019 | 70705710 |
Cystic fibrosis respiratory infection suppression | 13.71 | 10.14 | 11 | 213704 | 424 | 70714305 |
Vocal cord disorder | 13.70 | 10.14 | 19 | 213696 | 1392 | 70713337 |
Hepatic cancer | 13.69 | 10.14 | 6 | 213709 | 9677 | 70705052 |
Serum ferritin increased | 13.68 | 10.14 | 5 | 213710 | 9000 | 70705729 |
Anaphylactic shock | 13.67 | 10.14 | 154 | 213561 | 32336 | 70682393 |
Expiratory reserve volume decreased | 13.60 | 10.14 | 6 | 213709 | 73 | 70714656 |
Prostatomegaly | 13.58 | 10.14 | 30 | 213685 | 3189 | 70711540 |
Abortion | 13.57 | 10.14 | 18 | 213697 | 1264 | 70713465 |
Pneumococcal infection | 13.56 | 10.14 | 15 | 213700 | 871 | 70713858 |
Dizziness exertional | 13.49 | 10.14 | 12 | 213703 | 534 | 70714195 |
Abdominal pain lower | 13.40 | 10.14 | 42 | 213673 | 28174 | 70686555 |
Nodular vasculitis | 13.40 | 10.14 | 5 | 213710 | 38 | 70714691 |
Pneumonia viral | 13.39 | 10.14 | 55 | 213660 | 8237 | 70706492 |
Ear swelling | 13.33 | 10.14 | 19 | 213696 | 1428 | 70713301 |
Oesophagogastroduodenoscopy | 13.33 | 10.14 | 8 | 213707 | 191 | 70714538 |
Bronchiolitis | 13.30 | 10.14 | 33 | 213682 | 3781 | 70710948 |
Vaccination site swelling | 13.28 | 10.14 | 5 | 213710 | 39 | 70714690 |
Decreased activity | 13.27 | 10.14 | 52 | 213663 | 7622 | 70707107 |
Injection site swelling | 13.26 | 10.14 | 193 | 213522 | 42964 | 70671765 |
Breast conserving surgery | 13.20 | 10.14 | 13 | 213702 | 659 | 70714070 |
Febrile convulsion | 13.19 | 10.14 | 15 | 213700 | 898 | 70713831 |
Obsessive thoughts | 13.18 | 10.14 | 16 | 213699 | 1027 | 70713702 |
Fatigue | 13.14 | 10.14 | 2742 | 210973 | 821577 | 69893152 |
Duodenal ulcer | 13.13 | 10.14 | 16 | 213699 | 15264 | 70699465 |
Otorrhoea | 13.11 | 10.14 | 20 | 213695 | 1598 | 70713131 |
Distal intestinal obstruction syndrome | 13.10 | 10.14 | 13 | 213702 | 665 | 70714064 |
Body mass index increased | 13.10 | 10.14 | 21 | 213694 | 1751 | 70712978 |
Functional residual capacity decreased | 13.05 | 10.14 | 6 | 213709 | 81 | 70714648 |
Laryngeal stenosis | 13.05 | 10.14 | 15 | 213700 | 909 | 70713820 |
Acute sinusitis | 13.05 | 10.14 | 35 | 213680 | 4206 | 70710523 |
Hand fracture | 13.04 | 10.14 | 41 | 213674 | 5386 | 70709343 |
Leukoencephalopathy | 13.00 | 10.14 | 3 | 213712 | 7291 | 70707438 |
Premature delivery | 12.96 | 10.14 | 28 | 213687 | 21276 | 70693453 |
Self esteem decreased | 12.93 | 10.14 | 15 | 213700 | 918 | 70713811 |
Adjustment disorder | 12.92 | 10.14 | 29 | 213686 | 3115 | 70711614 |
Bladder cancer | 12.86 | 10.14 | 20 | 213695 | 17222 | 70697507 |
COVID-19 immunisation | 12.76 | 10.14 | 16 | 213699 | 1062 | 70713667 |
Infusion site haemorrhage | 12.75 | 10.14 | 27 | 213688 | 2788 | 70711941 |
Cardiac tamponade | 12.68 | 10.14 | 5 | 213710 | 8590 | 70706139 |
Crepitations | 12.68 | 10.14 | 56 | 213659 | 8658 | 70706071 |
Mandibular mass | 12.66 | 10.14 | 8 | 213707 | 210 | 70714519 |
Lymphostasis | 12.65 | 10.14 | 4 | 213711 | 17 | 70714712 |
Graft versus host disease | 12.63 | 10.14 | 16 | 213699 | 15007 | 70699722 |
Gallbladder disorder | 12.58 | 10.14 | 94 | 213621 | 17618 | 70697111 |
Haematocrit decreased | 12.58 | 10.14 | 111 | 213604 | 57147 | 70657582 |
Urosepsis | 12.58 | 10.14 | 34 | 213681 | 23915 | 70690814 |
Product appearance confusion | 12.57 | 10.14 | 5 | 213710 | 46 | 70714683 |
Unintentional medical device removal | 12.56 | 10.14 | 3 | 213712 | 7121 | 70707608 |
Hyperplastic cholecystopathy | 12.50 | 10.14 | 7 | 213708 | 146 | 70714583 |
Cephalo-pelvic disproportion | 12.50 | 10.14 | 7 | 213708 | 146 | 70714583 |
Hypernatraemia | 12.48 | 10.14 | 12 | 213703 | 12749 | 70701980 |
Nocturnal dyspnoea | 12.42 | 10.14 | 18 | 213697 | 1373 | 70713356 |
Myositis | 12.38 | 10.14 | 21 | 213694 | 17468 | 70697261 |
Fight in school | 12.35 | 10.14 | 3 | 213712 | 3 | 70714726 |
Platelet adhesiveness decreased | 12.35 | 10.14 | 3 | 213712 | 3 | 70714726 |
Chronic rhinosinusitis with nasal polyps | 12.35 | 10.14 | 3 | 213712 | 3 | 70714726 |
Upper airway resistance syndrome | 12.35 | 10.14 | 3 | 213712 | 3 | 70714726 |
Allergy to fermented products | 12.35 | 10.14 | 3 | 213712 | 3 | 70714726 |
Upper respiratory tract congestion | 12.35 | 10.14 | 24 | 213691 | 2330 | 70712399 |
Constipation | 12.34 | 10.14 | 628 | 213087 | 251810 | 70462919 |
Pregnancy | 12.31 | 10.14 | 34 | 213681 | 23747 | 70690982 |
Defiant behaviour | 12.29 | 10.14 | 4 | 213711 | 19 | 70714710 |
Autophobia | 12.29 | 10.14 | 4 | 213711 | 19 | 70714710 |
Cold agglutinins positive | 12.29 | 10.14 | 5 | 213710 | 49 | 70714680 |
Uveitis | 12.28 | 10.14 | 16 | 213699 | 14829 | 70699900 |
Photosensitivity reaction | 12.28 | 10.14 | 100 | 213615 | 19240 | 70695489 |
Tumour lysis syndrome | 12.24 | 10.14 | 29 | 213686 | 21331 | 70693398 |
Epstein-Barr virus infection | 12.23 | 10.14 | 13 | 213702 | 13185 | 70701544 |
Parkinsonism | 12.19 | 10.14 | 17 | 213698 | 15308 | 70699421 |
Injection site rash | 12.18 | 10.14 | 88 | 213627 | 16322 | 70698407 |
Flushing | 12.13 | 10.14 | 329 | 213386 | 81843 | 70632886 |
Diverticulum oesophageal | 12.13 | 10.14 | 7 | 213708 | 155 | 70714574 |
Benign renal neoplasm | 12.12 | 10.14 | 4 | 213711 | 20 | 70714709 |
Myalgia | 12.03 | 10.14 | 620 | 213095 | 167272 | 70547457 |
Onychophagia | 12.03 | 10.14 | 6 | 213709 | 98 | 70714631 |
Gastric cancer | 11.96 | 10.14 | 6 | 213709 | 8949 | 70705780 |
Device related infection | 11.96 | 10.14 | 53 | 213662 | 32132 | 70682597 |
Dermatitis acneiform | 11.94 | 10.14 | 6 | 213709 | 8939 | 70705790 |
Hepatic cytolysis | 11.87 | 10.14 | 25 | 213690 | 19167 | 70695562 |
Hepatitis | 11.83 | 10.14 | 95 | 213620 | 49885 | 70664844 |
Nasal pruritus | 11.79 | 10.14 | 10 | 213705 | 417 | 70714312 |
Lung opacity | 11.78 | 10.14 | 31 | 213684 | 3682 | 70711047 |
Hypothermia | 11.77 | 10.14 | 28 | 213687 | 20566 | 70694163 |
Head banging | 11.77 | 10.14 | 11 | 213704 | 522 | 70714207 |
Gastroenteritis eosinophilic | 11.77 | 10.14 | 8 | 213707 | 238 | 70714491 |
Ventricular fibrillation | 11.75 | 10.14 | 42 | 213673 | 27069 | 70687660 |
Conjunctivitis allergic | 11.75 | 10.14 | 16 | 213699 | 1152 | 70713577 |
Animal scratch | 11.73 | 10.14 | 16 | 213699 | 1154 | 70713575 |
Arthralgia | 11.69 | 10.14 | 1333 | 212382 | 502057 | 70212672 |
Respiratory fume inhalation disorder | 11.67 | 10.14 | 7 | 213708 | 167 | 70714562 |
Fibromyalgia | 11.66 | 10.14 | 206 | 213509 | 47668 | 70667061 |
Blood phosphorus increased | 11.65 | 10.14 | 3 | 213712 | 6767 | 70707962 |
Granulocytopenia | 11.64 | 10.14 | 9 | 213706 | 10638 | 70704091 |
Product availability issue | 11.62 | 10.14 | 27 | 213688 | 2967 | 70711762 |
Steroid diabetes | 11.60 | 10.14 | 27 | 213688 | 2970 | 70711759 |
Product container issue | 11.60 | 10.14 | 15 | 213700 | 1027 | 70713702 |
Injection site eczema | 11.55 | 10.14 | 5 | 213710 | 58 | 70714671 |
Epilepsy | 11.51 | 10.14 | 69 | 213646 | 38715 | 70676014 |
Hypovolaemia | 11.51 | 10.14 | 19 | 213696 | 15974 | 70698755 |
Mental status changes | 11.49 | 10.14 | 128 | 213587 | 62973 | 70651756 |
Abnormal weight gain | 11.48 | 10.14 | 23 | 213692 | 2283 | 70712446 |
Muscular weakness | 11.48 | 10.14 | 323 | 213392 | 138013 | 70576716 |
Dyskinesia oesophageal | 11.47 | 10.14 | 5 | 213710 | 59 | 70714670 |
Hyperglycaemia | 11.46 | 10.14 | 132 | 213583 | 64540 | 70650189 |
Gastric ulcer | 11.42 | 10.14 | 53 | 213662 | 31737 | 70682992 |
Lip discolouration | 11.41 | 10.14 | 12 | 213703 | 658 | 70714071 |
Bradyphrenia | 11.40 | 10.14 | 8 | 213707 | 9938 | 70704791 |
Oral allergy syndrome | 11.40 | 10.14 | 5 | 213710 | 60 | 70714669 |
Measles | 11.35 | 10.14 | 9 | 213706 | 341 | 70714388 |
Ankylosing spondylitis | 11.33 | 10.14 | 11 | 213704 | 11635 | 70703094 |
Autism spectrum disorder | 11.29 | 10.14 | 15 | 213700 | 1055 | 70713674 |
Bone density decreased | 11.25 | 10.14 | 66 | 213649 | 11408 | 70703321 |
Faecaloma | 11.22 | 10.14 | 9 | 213706 | 10442 | 70704287 |
BK virus infection | 11.22 | 10.14 | 5 | 213710 | 7984 | 70706745 |
Blood albumin decreased | 11.19 | 10.14 | 32 | 213683 | 22095 | 70692634 |
Sinus pain | 11.18 | 10.14 | 27 | 213688 | 3042 | 70711687 |
Vaccination site pain | 11.17 | 10.14 | 6 | 213709 | 115 | 70714614 |
Coronary artery disease | 11.14 | 10.14 | 128 | 213587 | 62608 | 70652121 |
Bronchitis viral | 11.12 | 10.14 | 15 | 213700 | 1070 | 70713659 |
Small airways disease | 11.12 | 10.14 | 4 | 213711 | 27 | 70714702 |
Choking | 11.09 | 10.14 | 64 | 213651 | 10996 | 70703733 |
Drug level decreased | 11.08 | 10.14 | 13 | 213702 | 12611 | 70702118 |
Graft versus host disease in lung | 11.06 | 10.14 | 13 | 213702 | 807 | 70713922 |
Lower gastrointestinal haemorrhage | 11.05 | 10.14 | 17 | 213698 | 14703 | 70700026 |
Neutrophilia | 10.98 | 10.14 | 4 | 213711 | 7217 | 70707512 |
Miller Fisher syndrome | 10.93 | 10.14 | 7 | 213708 | 188 | 70714541 |
Mycotic allergy | 10.92 | 10.14 | 15 | 213700 | 1089 | 70713640 |
Enterocolitis | 10.90 | 10.14 | 14 | 213701 | 13052 | 70701677 |
Hyperammonaemia | 10.88 | 10.14 | 9 | 213706 | 10284 | 70704445 |
Blood immunoglobulin E abnormal | 10.88 | 10.14 | 4 | 213711 | 29 | 70714700 |
Violence-related symptom | 10.81 | 10.14 | 12 | 213703 | 700 | 70714029 |
Renal injury | 10.78 | 10.14 | 20 | 213695 | 16074 | 70698655 |
Sinus headache | 10.76 | 10.14 | 34 | 213681 | 4479 | 70710250 |
Hiatus hernia | 10.70 | 10.14 | 104 | 213611 | 21030 | 70693699 |
Drug ineffective for unapproved indication | 10.70 | 10.14 | 70 | 213645 | 38468 | 70676261 |
Anticholinergic syndrome | 10.62 | 10.14 | 26 | 213689 | 2954 | 70711775 |
Hypervolaemia | 10.58 | 10.14 | 73 | 213642 | 39633 | 70675096 |
Anal abscess | 10.58 | 10.14 | 6 | 213709 | 8352 | 70706377 |
Pertussis | 10.57 | 10.14 | 13 | 213702 | 846 | 70713883 |
Systemic inflammatory response syndrome | 10.56 | 10.14 | 10 | 213705 | 10702 | 70704027 |
Injection site erythema | 10.49 | 10.14 | 291 | 213424 | 72633 | 70642096 |
Neurogenic shock | 10.49 | 10.14 | 11 | 213704 | 601 | 70714128 |
Hemiplegia | 10.48 | 10.14 | 16 | 213699 | 13879 | 70700850 |
Duodenitis | 10.45 | 10.14 | 4 | 213711 | 6998 | 70707731 |
Enteritis | 10.44 | 10.14 | 14 | 213701 | 12817 | 70701912 |
Occupational exposure to dust | 10.43 | 10.14 | 4 | 213711 | 33 | 70714696 |
Akathisia | 10.43 | 10.14 | 13 | 213702 | 12280 | 70702449 |
Concussion | 10.41 | 10.14 | 52 | 213663 | 8457 | 70706272 |
Bacterial sepsis | 10.40 | 10.14 | 5 | 213710 | 7642 | 70707087 |
Squamous cell carcinoma of the oral cavity | 10.40 | 10.14 | 10 | 213705 | 492 | 70714237 |
Reaction to excipient | 10.40 | 10.14 | 17 | 213698 | 1441 | 70713288 |
Laryngitis fungal | 10.35 | 10.14 | 6 | 213709 | 134 | 70714595 |
Foot deformity | 10.35 | 10.14 | 30 | 213685 | 20625 | 70694104 |
Tearfulness | 10.34 | 10.14 | 36 | 213679 | 4984 | 70709745 |
Hyperventilation | 10.32 | 10.14 | 46 | 213669 | 7140 | 70707589 |
Cardiac failure congestive | 10.31 | 10.14 | 320 | 213395 | 135137 | 70579592 |
Laziness | 10.30 | 10.14 | 12 | 213703 | 738 | 70713991 |
Blood immunoglobulin E | 10.29 | 10.14 | 3 | 213712 | 9 | 70714720 |
Suspected suicide | 10.27 | 10.14 | 7 | 213708 | 8827 | 70705902 |
Red blood cell count decreased | 10.23 | 10.14 | 104 | 213611 | 52057 | 70662672 |
Oral pruritus | 10.22 | 10.14 | 20 | 213695 | 1951 | 70712778 |
Decreased interest | 10.19 | 10.14 | 28 | 213687 | 3413 | 70711316 |
Prescribed overdose | 10.18 | 10.14 | 126 | 213589 | 27055 | 70687674 |
Acute coronary syndrome | 10.18 | 10.14 | 29 | 213686 | 20050 | 70694679 |
None
Source | Code | Description |
---|---|---|
ATC | R03DC03 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES Leukotriene receptor antagonists |
ATC | R03DC53 | RESPIRATORY SYSTEM DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES Leukotriene receptor antagonists |
FDA MoA | N0000000083 | Leukotriene Receptor Antagonists |
MeSH PA | D018927 | Anti-Asthmatic Agents |
MeSH PA | D065694 | Cytochrome P-450 CYP1A2 Inducers |
MeSH PA | D006727 | Hormone Antagonists |
MeSH PA | D020024 | Leukotriene Antagonists |
MeSH PA | D065606 | Metabolic Side Effects of Drugs and Substances |
MeSH PA | D019141 | Respiratory System Agents |
FDA EPC | N0000175777 | Leukotriene Receptor Antagonist |
CHEBI has role | CHEBI:38070 | antiarrhythmic agent |
CHEBI has role | CHEBI:49159 | leukotriene antagonists |
CHEBI has role | CHEBI:49167 | anti-asthmatic drugs |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Allergic rhinitis | indication | 61582004 | |
Non-allergic asthma | indication | 266361008 | DOID:9360 |
Allergic asthma | indication | 389145006 | DOID:9415 |
Asthma management | indication | 406162001 | |
Exercise-Induced Bronchospasm Prevention | indication | ||
Suicidal thoughts | contraindication | 6471006 | |
Hallucinations | contraindication | 7011001 | |
Mood swings | contraindication | 18963009 | |
Feeling agitated | contraindication | 24199005 | |
Depressive disorder | contraindication | 35489007 | |
Anxiety | contraindication | 48694002 | |
Vasculitis of the skin | contraindication | 53312001 | |
Dream disorder | contraindication | 85418005 | |
Eosinophil count raised | contraindication | 386789004 | |
Tremors | contraindication | ||
Nervousness | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.28 | acidic |
pKa2 | 4.98 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Cysteinyl leukotriene receptor 1 | GPCR | ANTAGONIST | Ki | 9.30 | CHEMBL | CHEMBL | |||
Alpha-2A adrenergic receptor | GPCR | Ki | 5.83 | DRUG MATRIX | |||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 5.57 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 2B | GPCR | Ki | 5.40 | DRUG MATRIX | |||||
D(3) dopamine receptor | GPCR | Ki | 5.58 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M1 | GPCR | Ki | 5.71 | DRUG MATRIX | |||||
Muscarinic acetylcholine receptor M3 | GPCR | Ki | 5.85 | DRUG MATRIX | |||||
Beta-3 adrenergic receptor | GPCR | Ki | 5.50 | DRUG MATRIX | |||||
Alpha-2C adrenergic receptor | GPCR | Ki | 6.12 | DRUG MATRIX | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 5.69 | DRUG MATRIX | |||||
Adenosine receptor A3 | GPCR | Ki | 6.61 | DRUG MATRIX | |||||
Cytochrome P450 2C8 | Enzyme | Ki | 5.96 | WOMBAT-PK | |||||
Delta-type opioid receptor | GPCR | Ki | 5.77 | DRUG MATRIX | |||||
Arachidonate 5-lipoxygenase | Enzyme | Ki | 4.33 | WOMBAT-PK | |||||
Epidermal growth factor receptor | Kinase | IC50 | 5.50 | DRUG MATRIX | |||||
Tyrosine-protein kinase Fyn | Kinase | IC50 | 5.33 | DRUG MATRIX | |||||
Thromboxane-A synthase | Enzyme | IC50 | 5.82 | DRUG MATRIX | |||||
Cysteinyl leukotriene receptor 2 | GPCR | Ki | 5.30 | PDSP | |||||
Mitogen-activated protein kinase 14 | Kinase | IC50 | 6.07 | DRUG MATRIX | |||||
Substance-K receptor | GPCR | Ki | 5.90 | DRUG MATRIX | |||||
Uracil nucleotide/cysteinyl leukotriene receptor | GPCR | Ki | 5.18 | CHEMBL | |||||
Beta-2 adrenergic receptor | GPCR | Ki | 5.62 | DRUG MATRIX | |||||
Cysteinyl leukotriene receptor 1 | GPCR | Ki | 9.30 | CHEMBL | |||||
Uracil nucleotide/cysteinyl leukotriene receptor | GPCR | ANTAGONIST | IC50 | 7.21 | IUPHAR |
ID | Source |
---|---|
4024117 | VUID |
N0000022122 | NUI |
D00529 | KEGG_DRUG |
151767-02-1 | SECONDARY_CAS_RN |
4021110 | VANDF |
4024117 | VANDF |
C0298130 | UMLSCUI |
CHEBI:50730 | CHEBI |
MTK | PDB_CHEM_ID |
CHEMBL787 | ChEMBL_ID |
CHEMBL1200681 | ChEMBL_ID |
DB00471 | DRUGBANK_ID |
C093875 | MESH_SUPPLEMENTAL_RECORD_UI |
3340 | IUPHAR_LIGAND_ID |
7388 | INN_ID |
MHM278SD3E | UNII |
5281040 | PUBCHEM_CID |
115713 | RXNORM |
11578 | MMSL |
189710 | MMSL |
5134 | MMSL |
d04289 | MMSL |
007256 | NDDF |
007257 | NDDF |
108620002 | SNOMEDCT_US |
320883008 | SNOMEDCT_US |
373728005 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Montelukast Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7487 | GRANULE | 4 mg | ORAL | ANDA | 31 sections |
Montelukast Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7487 | GRANULE | 4 mg | ORAL | ANDA | 31 sections |
MONTELUKAST | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9649 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 25 sections |
MONTELUKAST | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9650 | TABLET, CHEWABLE | 5 mg | ORAL | ANDA | 25 sections |
MONTELUKAST | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9651 | TABLET, CHEWABLE | 4 mg | ORAL | ANDA | 25 sections |
Montelukast | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5554 | TABLET, CHEWABLE | 4 mg | ORAL | ANDA | 28 sections |
Montelukast | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5555 | TABLET, CHEWABLE | 5 mg | ORAL | ANDA | 28 sections |
Montelukast | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-5560 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 28 sections |
Montelukast | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6808 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 28 sections |
Montelukast Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-079 | TABLET, CHEWABLE | 4 mg | ORAL | ANDA | 29 sections |
Montelukast Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-079 | TABLET, CHEWABLE | 4 mg | ORAL | ANDA | 29 sections |
Montelukast Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-079 | TABLET, CHEWABLE | 4 mg | ORAL | ANDA | 29 sections |
Montelukast Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-080 | TABLET, CHEWABLE | 5 mg | ORAL | ANDA | 29 sections |
Montelukast Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-080 | TABLET, CHEWABLE | 5 mg | ORAL | ANDA | 29 sections |
Montelukast Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-080 | TABLET, CHEWABLE | 5 mg | ORAL | ANDA | 29 sections |
Montelukast Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-081 | TABLET | 10 mg | ORAL | ANDA | 29 sections |
Montelukast Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-081 | TABLET | 10 mg | ORAL | ANDA | 29 sections |
Montelukast Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-081 | TABLET | 10 mg | ORAL | ANDA | 29 sections |
MONTELUKAST SODIUM ORAL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-531 | GRANULE | 4 mg | ORAL | ANDA | 19 sections |
MONTELUKAST SODIUM ORAL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-531 | GRANULE | 4 mg | ORAL | ANDA | 19 sections |
MONTELUKAST SODIUM ORAL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-531 | GRANULE | 4 mg | ORAL | ANDA | 19 sections |
MONTELUKAST SODIUM ORAL | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-531 | GRANULE | 4 mg | ORAL | ANDA | 19 sections |
Montelukast Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-119 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 28 sections |
SINGULAIR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-221 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 28 sections |
SINGULAIR | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-565 | TABLET, CHEWABLE | 5 mg | ORAL | NDA | 28 sections |
MONTELUKAST SODIUM | Human Prescription Drug Label | 1 | 27241-015 | GRANULE | 4 mg | ORAL | ANDA | 28 sections |
MONTELUKAST SODIUM | Human Prescription Drug Label | 1 | 27241-016 | TABLET, CHEWABLE | 4 mg | ORAL | ANDA | 28 sections |
MONTELUKAST SODIUM | Human Prescription Drug Label | 1 | 27241-017 | TABLET, CHEWABLE | 5 mg | ORAL | ANDA | 28 sections |
MONTELUKAST SODIUM | Human Prescription Drug Label | 1 | 27241-018 | TABLET, COATED | 10 mg | ORAL | ANDA | 28 sections |
montelukast sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 29300-220 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 26 sections |