montelukast Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
leukotriene receptor antagonists 1836 158966-92-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • montelukast
  • montelukast sodium
  • singulair
Montelukast is an orally active compound that binds with high affinity and selectivity to the CysLT1 receptor (in preference to other pharmacologically important airway receptors, such as the prostanoid, cholinergic, or beta-adrenergic receptor). Montelukast inhibits physiologic actions of cysteinyl leukotriene LTD4 at the CysLT1 receptor without any agonist activity.
  • Molecular weight: 586.19
  • Formula: C35H36ClNO3S
  • CLOGP: 8.47
  • LIPINSKI: 2
  • HAC: 4
  • HDO: 2
  • TPSA: 70.42
  • ALOGS: -7.85
  • ROTB: 12

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.20 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.28 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 62 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.15 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.68 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.00 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1998 FDA MERCK

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 4936.93 9.90 3460 162994 105512 53077100
Wheezing 1628.17 9.90 1462 164992 63813 53118799
Eosinophilic granulomatosis with polyangiitis 1229.50 9.90 399 166055 1800 53180812
Obstructive airways disorder 682.12 9.90 508 165946 16921 53165691
Cough 603.60 9.90 1966 164488 254927 52927685
Dyspnoea 598.39 9.90 3484 162970 582748 52599864
Sputum discoloured 561.24 9.90 418 166036 13921 53168691
Productive cough 475.17 9.90 725 165729 56004 53126608
Forced expiratory volume decreased 444.16 9.90 254 166200 5331 53177281
Sleep disorder due to a general medical condition 422.70 9.90 273 166181 7184 53175428
Chest discomfort 406.26 9.90 935 165519 98760 53083852
Urticaria 324.65 9.90 1047 165407 134838 53047774
Pemphigus 307.85 9.90 3 166451 104028 53078584
Toxicity to various agents 305.14 9.90 152 166302 219446 52963166
Sinusitis 291.89 9.90 1169 165285 167395 53015217
Blood count abnormal 289.69 9.90 337 166117 19978 53162634
Rheumatoid arthritis 269.65 9.90 352 166102 314179 52868433
Bronchitis 268.82 9.90 864 165590 111035 53071577
Nasal congestion 252.26 9.90 531 165923 52756 53129856
Synovitis 241.80 9.90 27 166427 107866 53074746
Food allergy 236.56 9.90 200 166254 8018 53174594
Hand deformity 236.22 9.90 6 166448 84843 53097769
Treatment failure 221.43 9.90 63 166391 128340 53054272
Upper respiratory tract infection 218.99 9.90 589 165865 68508 53114104
Chronic obstructive pulmonary disease 214.45 9.90 541 165913 60532 53122080
Systemic lupus erythematosus 206.38 9.90 67 166387 125347 53057265
Blood immunoglobulin E increased 196.76 9.90 109 166345 2146 53180466
Anaphylactic reaction 194.77 9.90 507 165947 57819 53124793
Contraindicated product administered 191.11 9.90 92 166362 135537 53047075
Glossodynia 186.79 9.90 42 166412 100249 53082363
Nasal polyps 186.24 9.90 116 166338 2860 53179752
Nightmare 185.31 9.90 252 166202 17499 53165113
Drug intolerance 181.07 9.90 225 166229 205268 52977344
Acute kidney injury 177.33 9.90 326 166128 253542 52929070
Asthmatic crisis 177.21 9.90 95 166359 1748 53180864
Temperature regulation disorder 176.68 9.90 128 166326 4079 53178533
Neutropenia 176.00 9.90 143 166311 159042 53023570
Rhinitis allergic 160.54 9.90 157 166297 7616 53174996
Eosinophil count increased 158.47 9.90 172 166282 9440 53173172
Joint swelling 154.52 9.90 312 166142 234326 52948286
Pneumonia 152.64 9.90 1939 164515 405230 52777382
Middle insomnia 151.58 9.90 177 166277 10531 53172081
Completed suicide 149.24 9.90 127 166327 138074 53044538
Arthropathy 146.71 9.90 135 166319 141318 53041294
Influenza 144.20 9.90 635 165819 94744 53087868
Seasonal allergy 140.26 9.90 204 166250 15081 53167531
Death 137.06 9.90 611 165843 356621 52825991
Infusion related reaction 136.03 9.90 172 166282 155785 53026827
Pericarditis 134.90 9.90 20 166434 64386 53118226
Drug interaction 134.10 9.90 304 166150 219025 52963587
Sleep apnoea syndrome 133.48 9.90 268 166186 25734 53156878
Therapeutic product effect incomplete 133.43 9.90 604 165850 91180 53091432
Dyspnoea exertional 133.14 9.90 426 166028 54574 53128038
Coeliac disease 133.12 9.90 150 166304 8585 53174027
Anaemia 132.12 9.90 433 166021 276285 52906327
Product quality issue 132.05 9.90 330 166124 36693 53145919
Thrombocytopenia 130.61 9.90 144 166310 138583 53044029
Pancytopenia 129.09 9.90 61 166393 90867 53091745
Breath sounds abnormal 128.21 9.90 145 166309 8332 53174280
Sleep terror 127.36 9.90 59 166395 781 53181831
Gastrooesophageal reflux disease 123.92 9.90 549 165905 82114 53100498
Malignant neoplasm progression 123.47 9.90 35 166419 71506 53111106
Maternal exposure during pregnancy 118.52 9.90 189 166265 155450 53027162
Alopecia 116.89 9.90 360 166094 234223 52948389
Off label use 116.80 9.90 929 165525 471283 52711329
Febrile neutropenia 116.27 9.90 94 166360 104842 53077770
Upper-airway cough syndrome 115.04 9.90 143 166311 9084 53173528
Drug abuse 113.19 9.90 32 166422 65494 53117118
Bronchospasm 111.43 9.90 192 166262 16406 53166206
Infective pulmonary exacerbation of cystic fibrosis 109.87 9.90 154 166300 11002 53171610
Hyponatraemia 109.84 9.90 106 166348 108501 53074111
Rhinorrhoea 107.70 9.90 390 166064 53188 53129424
Suicidal ideation 107.19 9.90 423 166031 60088 53122524
Respiratory tract congestion 106.61 9.90 176 166278 14523 53168089
Aggression 100.17 9.90 224 166230 23179 53159433
General physical health deterioration 99.57 9.90 192 166262 146750 53035862
Therapeutic product effect decreased 99.08 9.90 149 166305 125506 53057106
Peak expiratory flow rate decreased 98.99 9.90 47 166407 660 53181952
Wound 98.97 9.90 84 166370 91473 53091139
Headache 97.96 9.90 2276 164178 534545 52648067
Secretion discharge 97.53 9.90 141 166313 10365 53172247
Rhinitis 97.32 9.90 130 166324 8871 53173741
Anxiety 95.13 9.90 985 165469 195719 52986893
Product dose omission issue 87.25 9.90 948 165506 190672 52991940
Perfume sensitivity 86.77 9.90 42 166412 617 53181995
Immunodeficiency 86.25 9.90 162 166292 14805 53167807
Lung hyperinflation 86.06 9.90 52 166402 1212 53181400
Polycystic ovaries 86.03 9.90 65 166389 2211 53180401
Dysphonia 85.75 9.90 307 166147 41631 53140981
Sputum increased 84.58 9.90 64 166390 2182 53180430
Blood pressure systolic increased 83.78 9.90 271 166183 34906 53147706
Heart rate increased 83.53 9.90 490 165964 81825 53100787
Total lung capacity increased 83.27 9.90 45 166409 842 53181770
Respiratory rate increased 82.81 9.90 143 166311 12240 53170372
Stomatitis 82.72 9.90 111 166343 98047 53084565
Leukopenia 82.38 9.90 65 166389 73398 53109214
Respiratory tract infection 81.90 9.90 259 166195 32965 53149647
Multiple organ dysfunction syndrome 81.11 9.90 36 166418 55641 53126971
Chronic spontaneous urticaria 80.96 9.90 40 166414 616 53181996
Reversible airways obstruction 80.32 9.90 48 166406 1096 53181516
Status asthmaticus 79.85 9.90 45 166409 917 53181695
Helicobacter infection 79.84 9.90 13 166441 39056 53143556
Impaired healing 79.62 9.90 51 166403 64154 53118458
Muscle injury 79.60 9.90 3 166451 29763 53152849
Eczema 79.45 9.90 209 166245 23973 53158639
Vital capacity decreased 79.26 9.90 46 166408 993 53181619
Folliculitis 79.04 9.90 5 166449 31704 53150908
Sinus disorder 78.11 9.90 177 166277 18477 53164135
Loss of personal independence in daily activities 77.69 9.90 426 166028 69389 53113223
Disease progression 77.33 9.90 124 166330 101796 53080816
Abdominal discomfort 76.50 9.90 392 166062 220670 52961942
Hypotension 76.31 9.90 472 165982 253604 52929008
Pruritus 76.25 9.90 1314 165140 292518 52890094
Oropharyngeal pain 76.24 9.90 474 165980 80794 53101818
Throat irritation 74.48 9.90 243 166211 31438 53151174
Throat clearing 72.58 9.90 45 166409 1100 53181512
Renal impairment 72.48 9.90 92 166362 83226 53099386
Intentional overdose 72.21 9.90 62 166392 67143 53115469
Chronic sinusitis 70.71 9.90 90 166364 5855 53176757
Nasopharyngitis 70.59 9.90 913 165541 191382 52991230
Abnormal behaviour 68.82 9.90 186 166268 21680 53160932
Mucosal inflammation 68.34 9.90 24 166430 42760 53139852
Drug ineffective 67.24 9.90 1991 164463 815254 52367358
Respiratory symptom 67.21 9.90 60 166394 2589 53180023
Sensitivity to weather change 67.08 9.90 89 166365 6033 53176579
Dust allergy 66.12 9.90 35 166419 627 53181985
Sensitisation 65.96 9.90 45 166409 1300 53181312
Rales 65.87 9.90 120 166334 10712 53171900
Sneezing 65.69 9.90 143 166311 14529 53168083
Full blood count abnormal 65.33 9.90 70 166384 3785 53178827
Forced vital capacity decreased 65.03 9.90 41 166413 1033 53181579
Bradycardia 64.40 9.90 76 166378 70980 53111632
Septic shock 63.75 9.90 60 166394 62169 53120443
Respiration abnormal 63.22 9.90 82 166372 5436 53177176
Bronchial secretion retention 62.20 9.90 47 166407 1599 53181013
Sinus congestion 62.05 9.90 139 166315 14399 53168213
Blood test abnormal 61.42 9.90 121 166333 11456 53171156
Toxic epidermal necrolysis 60.90 9.90 3 166451 23547 53159065
Hyperkalaemia 60.83 9.90 48 166406 54208 53128404
Coma 60.49 9.90 62 166392 61721 53120891
Bone marrow failure 59.39 9.90 11 166443 30104 53152508
Cardiac failure 59.14 9.90 111 166343 85733 53096879
C-reactive protein increased 57.97 9.90 76 166378 67810 53114802
Bursitis 57.89 9.90 178 166276 22314 53160298
Metabolic acidosis 57.43 9.90 30 166424 42212 53140400
Abnormal dreams 56.48 9.90 111 166343 10490 53172122
Crying 56.20 9.90 175 166279 22087 53160525
Hypokalaemia 54.76 9.90 139 166315 96378 53086234
C-reactive protein abnormal 54.24 9.90 8 166446 25862 53156750
Eosinophilia 54.13 9.90 168 166286 21167 53161445
Smoke sensitivity 54.12 9.90 24 166430 285 53182327
Eye pruritus 53.30 9.90 125 166329 13344 53169268
Haemoglobin decreased 53.01 9.90 234 166220 137073 53045539
Cystic fibrosis 52.37 9.90 63 166391 3868 53178744
Poor quality device used 52.36 9.90 52 166402 2570 53180042
Malaise 51.72 9.90 1471 164983 356146 52826466
Sepsis 51.56 9.90 258 166196 146171 53036441
Pulmonary function test decreased 51.09 9.90 64 166390 4097 53178515
Throat tightness 50.96 9.90 169 166285 22047 53160565
Sleep disorder due to general medical condition, insomnia type 49.98 9.90 8 166446 24341 53158271
Rhonchi 49.08 9.90 49 166405 2437 53180175
Angioedema 49 9.90 260 166194 41816 53140796
Aspirin-exacerbated respiratory disease 48.35 9.90 32 166422 878 53181734
Bronchial disorder 48.28 9.90 36 166418 1200 53181412
Emphysema 47.97 9.90 100 166354 9859 53172753
Swelling 47.50 9.90 375 166079 190730 52991882
Hyper IgE syndrome 47.04 9.90 24 166430 397 53182215
Musculoskeletal stiffness 46.56 9.90 212 166242 123156 53059456
Mood altered 46.53 9.90 121 166333 13780 53168832
Sinusitis fungal 46.47 9.90 37 166417 1361 53181251
Depressed level of consciousness 46.40 9.90 61 166393 54367 53128245
Confusional state 46.04 9.90 386 166068 193835 52988777
Insomnia 45.73 9.90 829 165625 186243 52996369
Respiratory disorder 45.54 9.90 219 166235 33878 53148734
Dermatitis atopic 45.53 9.90 58 166396 3776 53178836
Blood pressure increased 44.97 9.90 651 165803 139828 53042784
Rash erythematous 44.85 9.90 234 166220 37389 53145223
Diarrhoea 44.78 9.90 1551 164903 623995 52558617
Ascites 44.74 9.90 35 166419 39700 53142912
Hypersensitivity 44.18 9.90 912 165542 209753 52972859
Product use issue 43.06 9.90 257 166197 139327 53043285
Restrictive pulmonary disease 42.94 9.90 37 166417 1522 53181090
Multiple allergies 42.92 9.90 87 166367 8408 53174204
Asthma-chronic obstructive pulmonary disease overlap syndrome 42.88 9.90 26 166428 610 53182002
Asthma exercise induced 42.88 9.90 21 166433 317 53182295
Metastases to bone 42.86 9.90 5 166449 19323 53163289
Mood swings 42.80 9.90 136 166318 17350 53165262
Scratch 42.36 9.90 65 166389 5039 53177573
Migraine 42.32 9.90 410 166044 80007 53102605
Idiopathic intracranial hypertension 42.22 9.90 47 166407 2653 53179959
Nasal oedema 41.62 9.90 30 166424 948 53181664
Infusion site pruritus 41.60 9.90 55 166399 3715 53178897
Hypoventilation 41.29 9.90 59 166395 4290 53178322
Cholestasis 41.09 9.90 19 166435 28676 53153936
Dehydration 40.68 9.90 333 166121 168077 53014535
Factor V Leiden mutation 40.57 9.90 18 166436 214 53182398
Pulmonary function test abnormal 40.53 9.90 35 166419 1444 53181168
Platelet count decreased 40.05 9.90 187 166267 107912 53074700
Anger 39.59 9.90 106 166348 12284 53170328
Neoplasm progression 39.57 9.90 22 166432 29897 53152715
Salpingo-oophorectomy unilateral 39.27 9.90 25 166429 641 53181971
Discomfort 39.12 9.90 159 166295 95313 53087299
Cholecystitis chronic 38.81 9.90 95 166359 10423 53172189
Bronchial obstruction 38.57 9.90 35 166419 1543 53181069
Bronchial neoplasm 38.38 9.90 21 166433 403 53182209
Cardiac arrest 38.38 9.90 156 166298 93511 53089101
Hepatocellular injury 38.30 9.90 23 166431 29963 53152649
Depression 38.21 9.90 792 165662 182260 53000352
Pulmonary mass 37.99 9.90 143 166311 19861 53162751
Bronchiectasis 37.91 9.90 95 166359 10577 53172035
Hepatotoxicity 37.60 9.90 20 166434 27860 53154752
Impaired quality of life 37.60 9.90 60 166394 4811 53177801
Illness 37.59 9.90 154 166300 22242 53160370
Gastrointestinal disorder 37.44 9.90 149 166305 89855 53092757
Alanine aminotransferase increased 37.34 9.90 161 166293 94934 53087678
Cardio-respiratory arrest 37.02 9.90 80 166374 58678 53123934
Bronchopulmonary aspergillosis allergic 36.69 9.90 31 166423 1241 53181371
Renal failure 36.57 9.90 218 166236 118234 53064378
Poor quality sleep 36.42 9.90 128 166326 17195 53165417
Ejection fraction 36.24 9.90 28 166426 985 53181627
Aphonia 36.14 9.90 84 166370 8914 53173698
Nasal turbinate hypertrophy 36.09 9.90 24 166430 664 53181948
Nasal discharge discolouration 35.62 9.90 34 166420 1600 53181012
Blister 35.61 9.90 126 166328 78627 53103985
Prolonged expiration 35.47 9.90 23 166431 609 53182003
Infusion site swelling 34.88 9.90 71 166383 6883 53175729
Cytomegalovirus infection 34.75 9.90 9 166445 19530 53163082
Palmar-plantar erythrodysaesthesia syndrome 34.71 9.90 12 166442 21594 53161018
Gastrointestinal haemorrhage 34.69 9.90 131 166323 80199 53102413
Bronchial haemorrhage 34.40 9.90 21 166433 499 53182113
Feeling abnormal 34.25 9.90 603 165851 134698 53047914
Infusion site erythema 33.96 9.90 81 166373 8741 53173871
Hereditary angioedema 33.95 9.90 66 166388 6187 53176425
Encephalopathy 33.74 9.90 39 166415 36769 53145843
Decreased appetite 33.71 9.90 470 165984 214504 52968108
Agranulocytosis 33.58 9.90 16 166438 23733 53158879
Lactic acidosis 33.58 9.90 40 166414 37213 53145399
Disseminated intravascular coagulation 33.36 9.90 10 166444 19709 53162903
Skin plaque 33.33 9.90 67 166387 6437 53176175
Lipohypertrophy 33.23 9.90 24 166430 761 53181851
Biliary dyskinesia 33.20 9.90 42 166412 2715 53179897
Atopy 33.18 9.90 16 166438 233 53182379
Haemoptysis 33.15 9.90 174 166280 27865 53154747
White blood cell count decreased 32.92 9.90 240 166214 124235 53058377
Metastases to liver 32.75 9.90 13 166441 21483 53161129
Red blood cell sedimentation rate increased 32.50 9.90 24 166430 28033 53154579
Bronchitis chronic 32.28 9.90 52 166402 4202 53178410
Eosinophil count abnormal 32.19 9.90 21 166433 562 53182050
Acute myeloid leukaemia 31.69 9.90 7 166447 16925 53165687
Neutrophil count decreased 31.64 9.90 66 166388 49032 53133580
Intentional product use issue 31.44 9.90 118 166336 72376 53110236
Weight increased 31.34 9.90 848 165606 203719 52978893
Viral infection 31.30 9.90 190 166264 32105 53150507
Colitis 31.08 9.90 51 166403 41501 53141111
Oxygen saturation decreased 30.98 9.90 371 166083 76354 53106258
Fluid retention 30.94 9.90 282 166172 54119 53128493
Frustration tolerance decreased 30.54 9.90 62 166392 5999 53176613
Sputum culture positive 30.47 9.90 30 166424 1467 53181145
Body tinea 30.07 9.90 27 166427 1174 53181438
Total lung capacity decreased 29.92 9.90 29 166425 1391 53181221
Circulatory collapse 29.61 9.90 17 166437 22697 53159915
Hepatic enzyme increased 29.34 9.90 252 166202 125943 53056669
Osteonecrosis of jaw 29.31 9.90 42 166412 36104 53146508
Increased viscosity of bronchial secretion 29.11 9.90 16 166438 310 53182302
Pharyngeal oedema 29.03 9.90 106 166348 14507 53168105
Blood creatinine increased 28.87 9.90 146 166308 82516 53100096
Humidity intolerance 28.85 9.90 17 166437 378 53182234
Vomiting 28.84 9.90 1263 165191 495876 52686736
Mastocytosis 28.64 9.90 18 166436 451 53182161
Blood bilirubin increased 28.50 9.90 42 166412 35688 53146924
Aspartate aminotransferase increased 28.46 9.90 150 166304 83879 53098733
Nasal obstruction 28.43 9.90 25 166429 1057 53181555
Interstitial lung disease 28.40 9.90 91 166363 58531 53124081
Inappropriate antidiuretic hormone secretion 28.35 9.90 6 166448 14945 53167667
Increased bronchial secretion 28.11 9.90 31 166423 1732 53180880
Rhabdomyolysis 27.50 9.90 60 166394 43863 53138749
Inflammation 27.47 9.90 89 166365 57047 53125565
Skin ulcer 27.33 9.90 44 166410 36075 53146537
Anosmia 27.28 9.90 49 166405 4326 53178286
Peritonitis 27.19 9.90 17 166437 21670 53160942
Irritability 26.83 9.90 177 166277 30776 53151836
Rash maculo-papular 26.75 9.90 32 166422 29717 53152895
Liver disorder 26.71 9.90 53 166401 40102 53142510
Pneumonia aspiration 26.70 9.90 41 166413 34260 53148352
Live birth 26.66 9.90 7 166447 15052 53167560
Inhibitory drug interaction 26.19 9.90 34 166420 2256 53180356
Hypocalcaemia 25.91 9.90 32 166422 29305 53153307
Anuria 25.73 9.90 4 166450 12436 53170176
Mononeuropathy multiplex 25.53 9.90 14 166440 270 53182342
Lung opacity 25.42 9.90 31 166423 1930 53180682
Eosinophilic pneumonia 25.42 9.90 33 166421 2189 53180423
Lymphocyte count decreased 25.41 9.90 30 166424 28022 53154590
Respiratory gas exchange disorder 25.38 9.90 17 166437 476 53182136
Gamma-glutamyltransferase increased 25.27 9.90 41 166413 33514 53149098
Urticaria chronic 25.19 9.90 18 166436 561 53182051
Swelling face 25.12 9.90 281 166173 56887 53125725
Hip arthroplasty 25.02 9.90 30 166424 27832 53154780
Increased upper airway secretion 24.90 9.90 41 166413 3375 53179237
Progressive multifocal leukoencephalopathy 24.86 9.90 4 166450 12125 53170487
Paranasal sinus discomfort 24.44 9.90 38 166416 2979 53179633
Neurosensory hypoacusis 24.42 9.90 14 166440 295 53182317
Knee arthroplasty 24.37 9.90 42 166412 33527 53149085
Occupational asthma 24.27 9.90 11 166443 138 53182474
Heart sounds 24.12 9.90 17 166437 518 53182094
Lower respiratory tract congestion 23.90 9.90 31 166423 2055 53180557
Neutropenic sepsis 23.77 9.90 8 166446 14641 53167971
Allergy test positive 23.72 9.90 15 166439 380 53182232
Ear infection 23.60 9.90 150 166304 25750 53156862
Acute respiratory distress syndrome 23.31 9.90 23 166431 23309 53159303
Embolism venous 23.23 9.90 37 166417 2962 53179650
Blood creatine phosphokinase increased 23.18 9.90 34 166420 28951 53153661
Nocturnal fear 23.17 9.90 6 166448 9 53182603
Pulmonary pain 23.10 9.90 32 166422 2260 53180352
Paraesthesia oral 23.00 9.90 91 166363 12934 53169678
Glucose tolerance impaired 22.85 9.90 51 166403 5269 53177343
Upper airway obstruction 22.63 9.90 18 166436 661 53181951
Hepatic function abnormal 22.62 9.90 51 166403 36848 53145764
Premature delivery 22.51 9.90 29 166425 26075 53156537
FEV1/FVC ratio decreased 22.39 9.90 9 166445 82 53182530
Allergy to animal 22.31 9.90 20 166434 868 53181744
Educational problem 22.27 9.90 14 166440 351 53182261
Breast cancer metastatic 22.18 9.90 10 166444 15318 53167294
Bone erosion 22.15 9.90 4 166450 11148 53171464
Endometrial ablation 22.13 9.90 20 166434 877 53181735
Drug reaction with eosinophilia and systemic symptoms 22.07 9.90 43 166411 32757 53149855
Palpitations 22.05 9.90 445 166009 101903 53080709
Infection susceptibility increased 22.03 9.90 33 166421 2504 53180108
Hypomagnesaemia 21.98 9.90 27 166427 24784 53157828
Swollen tongue 21.86 9.90 169 166285 30911 53151701
Lung diffusion test decreased 21.82 9.90 18 166436 697 53181915
Drug level increased 21.73 9.90 19 166435 20402 53162210
Atrial fibrillation 21.69 9.90 233 166221 111419 53071193
Irritable bowel syndrome 21.65 9.90 67 166387 43565 53139047
Type 2 diabetes mellitus 21.61 9.90 171 166283 31499 53151113
Hypoalbuminaemia 21.55 9.90 4 166450 10932 53171680
Hepatic failure 21.53 9.90 50 166404 35756 53146856
Pleural effusion 21.44 9.90 175 166279 88404 53094208
Nephrectomy 21.42 9.90 18 166436 715 53181897
Stress 21.30 9.90 272 166182 56812 53125800
Vocal cord dysfunction 21.14 9.90 13 166441 313 53182299
Lower respiratory tract infection 21.09 9.90 400 166054 90581 53092031
Separation anxiety disorder 20.98 9.90 7 166447 35 53182577
Nasal inflammation 20.89 9.90 15 166439 471 53182141
Ear discomfort 20.89 9.90 60 166394 7241 53175371
Creatinine renal clearance decreased 20.77 9.90 4 166450 10647 53171965
Anaphylactic shock 20.70 9.90 128 166326 21765 53160847
Infusion site extravasation 20.61 9.90 54 166400 6178 53176434
Neuroleptic malignant syndrome 20.55 9.90 6 166448 12027 53170585
Product substitution issue 20.53 9.90 101 166353 15765 53166847
Erythema 20.53 9.90 638 165816 156331 53026281
Infusion site pain 20.36 9.90 82 166372 11751 53170861
Delirium 20.29 9.90 64 166390 41365 53141247
Infection 20.22 9.90 397 166057 171808 53010804
Cerebral infarction 20.22 9.90 28 166426 24416 53158196
Mobility decreased 20.18 9.90 147 166307 76124 53106488
Hypoglycaemia 20.17 9.90 105 166349 58908 53123704
Eosinophilic oesophagitis 20.12 9.90 12 166442 273 53182339
Eye paraesthesia 19.89 9.90 8 166446 73 53182539
Exposure to allergen 19.88 9.90 11 166443 216 53182396
Chest pain 19.84 9.90 753 165701 189432 52993180
Rash 19.79 9.90 1165 165289 445026 52737586
Dyspnoea at rest 19.72 9.90 40 166414 3867 53178745
Mast cell activation syndrome 19.66 9.90 12 166442 285 53182327
Pulmonary arterial hypertension 19.63 9.90 34 166420 27088 53155524
Body temperature decreased 19.53 9.90 103 166351 16524 53166088
Airway peak pressure increased 19.51 9.90 12 166442 289 53182323
Stevens-Johnson syndrome 19.50 9.90 29 166425 24553 53158059
Influenza like illness 19.44 9.90 282 166172 60577 53122035
Gluten sensitivity 19.38 9.90 15 166439 529 53182083
Altered state of consciousness 19.03 9.90 30 166424 24806 53157806
Spirometry abnormal 19.01 9.90 11 166443 236 53182376
Pneumocystis jirovecii pneumonia 18.98 9.90 14 166440 16364 53166248
Adrenal suppression 18.90 9.90 19 166435 953 53181659
Haemophagocytic lymphohistiocytosis 18.76 9.90 3 166451 9134 53173478
Condition aggravated 18.63 9.90 748 165706 296386 52886226
Expiratory reserve volume decreased 18.54 9.90 7 166447 53 53182559
Diabetic ketoacidosis 18.36 9.90 21 166433 19894 53162718
Decubitus ulcer 18.35 9.90 5 166449 10488 53172124
Orthostatic hypotension 18.33 9.90 41 166413 29712 53152900
Affective disorder 18.32 9.90 48 166406 5491 53177121
Bronchial hyperreactivity 18.26 9.90 23 166431 1480 53181132
Thinking abnormal 18.22 9.90 73 166381 10435 53172177
Administration site erythema 18.15 9.90 15 166439 582 53182030
Lip swelling 18.08 9.90 146 166308 27055 53155557
Tuberculosis 18.04 9.90 6 166448 11065 53171547
Torsade de pointes 18.03 9.90 9 166445 12996 53169616
Burning sensation 18.01 9.90 229 166225 47784 53134828
Ankle fracture 17.84 9.90 100 166354 16415 53166197
Schizophrenia 17.78 9.90 5 166449 10274 53172338
Arthralgia 17.63 9.90 1159 165295 438624 52743988
Infusion site bruising 17.60 9.90 27 166427 2092 53180520
Cognitive disorder 17.45 9.90 76 166378 44702 53137910
Mite allergy 17.44 9.90 14 166440 521 53182091
Serotonin syndrome 17.43 9.90 35 166419 26371 53156241
Pharyngitis streptococcal 17.42 9.90 65 166389 8990 53173622
Paranoia 17.19 9.90 76 166378 11348 53171264
Lactose intolerance 17.15 9.90 31 166423 2750 53179862
Pneumococcal infection 17.13 9.90 13 166441 445 53182167
Somnambulism 17.04 9.90 46 166408 5356 53177256
Appetite disorder 17.04 9.90 52 166402 6491 53176121
Acute sinusitis 17.04 9.90 38 166416 3924 53178688
Infusion site urticaria 17.00 9.90 17 166437 847 53181765
Airway remodelling 16.93 9.90 7 166447 69 53182543
Blood alkaline phosphatase increased 16.86 9.90 69 166385 41293 53141319
Foetal exposure during pregnancy 16.74 9.90 54 166400 34661 53147951
Cortisol decreased 16.65 9.90 19 166435 1102 53181510
Transaminases increased 16.62 9.90 44 166410 30088 53152524
Ischaemic stroke 16.56 9.90 19 166435 17974 53164638
Pulmonary thrombosis 16.54 9.90 59 166395 7982 53174630
Lymphopenia 16.37 9.90 17 166437 16826 53165786
Neurogenic shock 16.30 9.90 11 166443 312 53182300
Epilepsy 16.30 9.90 35 166419 25732 53156880
Liver function test abnormal 16.17 9.90 86 166368 47985 53134627
Lung disorder 16.15 9.90 224 166230 47655 53134957
Acute hepatic failure 16.11 9.90 17 166437 16703 53165909
Myalgia 16 9.90 537 165917 132954 53049658
Drug eruption 15.94 9.90 34 166420 25060 53157552
Hyperhidrosis 15.88 9.90 405 166049 96388 53086224
Acute myocardial infarction 15.81 9.90 52 166402 33183 53149429
Metastases to central nervous system 15.75 9.90 9 166445 12048 53170564
Liver injury 15.73 9.90 28 166426 22075 53160537
Inappropriate schedule of product administration 15.61 9.90 324 166130 74554 53108058
Hypercalcaemia 15.46 9.90 33 166421 24315 53158297
Therapy non-responder 15.36 9.90 90 166364 49030 53133582
Product container issue 15.31 9.90 24 166430 1895 53180717
Hysterectomy 15.27 9.90 60 166394 8501 53174111
Left ventricular dysfunction 15.24 9.90 8 166446 11229 53171383
Gallbladder disorder 15.21 9.90 103 166351 18062 53164550
Ejection fraction decreased 15.18 9.90 24 166430 19824 53162788
Tenosynovitis 15.16 9.90 6 166448 9933 53172679
Nephropathy toxic 15.15 9.90 4 166450 8568 53174044
Sedation 15.13 9.90 45 166409 29630 53152982
Hypercapnia 15.06 9.90 42 166412 4985 53177627
Tic 15.00 9.90 20 166434 1362 53181250
Bronchial irritation 14.98 9.90 5 166449 25 53182587
Pain 14.92 9.90 1608 164846 586790 52595822
Myelodysplastic syndrome 14.90 9.90 18 166436 16642 53165970
Anticholinergic syndrome 14.89 9.90 24 166430 1940 53180672
Lip discolouration 14.84 9.90 13 166441 547 53182065
Oesophageal dilatation 14.82 9.90 11 166443 364 53182248
Vocal cord disorder 14.79 9.90 20 166434 1381 53181231
Ulcer 14.78 9.90 26 166428 20593 53162019
Bacteraemia 14.77 9.90 16 166438 15533 53167079
Mycotic allergy 14.71 9.90 16 166438 880 53181732
Pre-existing condition improved 14.68 9.90 57 166397 8032 53174580
International normalised ratio increased 14.68 9.90 88 166366 47673 53134939
Intentional product misuse 14.66 9.90 92 166362 49300 53133312
Respiratory tract irritation 14.65 9.90 12 166442 460 53182152
Obstruction 14.60 9.90 25 166429 2125 53180487
Accidental overdose 14.58 9.90 28 166426 21451 53161161
Miller Fisher syndrome 14.57 9.90 7 166447 101 53182511
Ear pruritus 14.55 9.90 27 166427 2444 53180168
Sarcoidosis 14.52 9.90 44 166410 5470 53177142
Weight decreased 14.45 9.90 883 165571 234065 52948547
Choking sensation 14.41 9.90 33 166421 3468 53179144
Respiratory tract inflammation 14.39 9.90 13 166441 570 53182042
Sleep study abnormal 14.32 9.90 3 166451 0 53182612
Glomus tumour 14.32 9.90 3 166451 0 53182612
Muscle spasticity 14.19 9.90 21 166433 17817 53164795
Bronchial wall thickening 14.16 9.90 17 166437 1041 53181571
Squamous cell carcinoma of the oral cavity 14.13 9.90 10 166444 307 53182305
Sputum retention 14.12 9.90 13 166441 584 53182028
Unresponsive to stimuli 14.11 9.90 55 166399 33371 53149241
Sinus headache 14.01 9.90 40 166414 4811 53177801
Hiatus hernia 13.97 9.90 107 166347 19513 53163099
Blood pressure fluctuation 13.95 9.90 60 166394 35410 53147202
Product packaging confusion 13.90 9.90 8 166446 170 53182442
Candida infection 13.85 9.90 130 166324 25143 53157469
Carpal tunnel syndrome 13.85 9.90 99 166355 17668 53164944
Oxygen consumption decreased 13.76 9.90 9 166445 242 53182370
Middle ear effusion 13.75 9.90 24 166430 2071 53180541
Proteinuria 13.68 9.90 22 166432 18046 53164566
Osteomyelitis 13.66 9.90 35 166419 24200 53158412
Mucosal discolouration 13.58 9.90 12 166442 511 53182101
Drug resistance 13.57 9.90 26 166428 19936 53162676
Ejection fraction abnormal 13.56 9.90 16 166438 962 53181650
Pulmonary eosinophilia 13.56 9.90 9 166445 248 53182364
Nervousness 13.55 9.90 149 166305 30029 53152583
PCO2 increased 13.51 9.90 18 166436 1225 53181387
Blood lactate dehydrogenase increased 13.43 9.90 30 166424 21751 53160861
Mandibular mass 13.41 9.90 8 166446 182 53182430
Overdose 13.37 9.90 246 166208 107490 53075122
Jaundice 13.36 9.90 49 166405 30264 53152348
Cytopenia 13.24 9.90 6 166448 9164 53173448
Cold agglutinins positive 13.23 9.90 5 166449 38 53182574
Product contamination physical 13.19 9.90 6 166448 76 53182536
Product prescribing error 13.18 9.90 33 166421 22998 53159614
Infusion site haemorrhage 13.17 9.90 28 166426 2799 53179813
Sinus operation 13.16 9.90 21 166433 1684 53180928
Panniculitis 13.15 9.90 4 166450 7810 53174802
Pregnancy 13.10 9.90 52 166402 31389 53151223
CFTR gene mutation 13.05 9.90 6 166448 78 53182534
Infusion site nodule 13.03 9.90 17 166437 1133 53181479
Laryngeal oedema 13.00 9.90 43 166411 5602 53177010
Acute generalised exanthematous pustulosis 12.97 9.90 8 166446 10273 53172339
Hepatic encephalopathy 12.95 9.90 9 166445 10850 53171762
Electrocardiogram QT prolonged 12.94 9.90 113 166341 56290 53126322
Muscle rigidity 12.91 9.90 9 166445 10832 53171780
Eczema impetiginous 12.91 9.90 4 166450 15 53182597
Miosis 12.89 9.90 3 166451 6999 53175613
Hypothermia 12.89 9.90 13 166441 13043 53169569
Sinus bradycardia 12.82 9.90 16 166438 14585 53168027
Pharyngeal swelling 12.81 9.90 38 166416 4670 53177942
Female reproductive neoplasm 12.69 9.90 5 166449 43 53182569
Amnesia 12.60 9.90 205 166249 45083 53137529
Exposure to fungus 12.58 9.90 7 166447 139 53182473
Mouth ulceration 12.54 9.90 48 166406 29278 53153334
Abnormal weight gain 12.54 9.90 20 166434 1603 53181009
Administration site swelling 12.53 9.90 17 166437 1177 53181435
Blood immunoglobulin E decreased 12.53 9.90 6 166448 86 53182526
Diverticulum oesophageal 12.49 9.90 7 166447 141 53182471
Premature baby 12.44 9.90 27 166427 19774 53162838
Respiratory arrest 12.43 9.90 58 166396 33482 53149130
Functional residual capacity decreased 12.40 9.90 6 166448 88 53182524
Malnutrition 12.33 9.90 17 166437 14854 53167758
Metastases to lung 12.32 9.90 11 166443 11693 53170919
Laryngitis fungal 12.32 9.90 7 166447 145 53182467
Skin necrosis 12.30 9.90 9 166445 10563 53172049
Platelet adhesiveness decreased 12.25 9.90 3 166451 3 53182609
Female genital tract fistula 12.25 9.90 34 166420 4024 53178588
Melaena 12.25 9.90 48 166406 29081 53153531
Cephalo-pelvic disproportion 12.23 9.90 8 166446 215 53182397
Pneumonia respiratory syncytial viral 12.21 9.90 13 166441 698 53181914
Oropharyngeal discomfort 12.20 9.90 34 166420 4034 53178578
Colitis ulcerative 12.19 9.90 30 166424 21031 53161581
Hypereosinophilic syndrome 12.17 9.90 9 166445 296 53182316
Serum sickness 12.17 9.90 26 166428 2607 53180005
Cardiac murmur 12.12 9.90 71 166383 11842 53170770
Pulmonary renal syndrome 12.02 9.90 10 166444 392 53182220
Fracture pain 12.02 9.90 10 166444 392 53182220
Forced expiratory volume 11.99 9.90 4 166450 20 53182592
Posterior reversible encephalopathy syndrome 11.93 9.90 20 166434 16140 53166472
Oliguria 11.92 9.90 7 166447 9231 53173381
Oral pruritus 11.82 9.90 20 166434 1683 53180929
Quality of life decreased 11.78 9.90 45 166409 6293 53176319
Product appearance confusion 11.78 9.90 5 166449 53 53182559
Phlebectomy 11.69 9.90 5 166449 54 53182558
Cardiogenic shock 11.69 9.90 23 166431 17459 53165153
Administration site pruritus 11.66 9.90 9 166445 316 53182296
Allergic sinusitis 11.66 9.90 12 166442 619 53181993
Sinus polyp 11.64 9.90 9 166445 317 53182295
Clostridium difficile colitis 11.56 9.90 28 166426 19737 53162875
Self-injurious ideation 11.47 9.90 24 166430 2372 53180240
Functional residual capacity increased 11.46 9.90 6 166448 105 53182507
Hyperplastic cholecystopathy 11.46 9.90 6 166448 105 53182507
Screaming 11.46 9.90 29 166425 3248 53179364
Coagulopathy 11.45 9.90 28 166426 19670 53162942
Otorrhoea 11.43 9.90 18 166436 1427 53181185
Neuropsychiatric syndrome 11.30 9.90 5 166449 59 53182553
Urinary retention 11.28 9.90 48 166406 28418 53154194
Obsessive thoughts 11.27 9.90 11 166443 532 53182080
Respiratory tract infection viral 11.25 9.90 21 166433 1910 53180702
Diverticulum 11.22 9.90 69 166385 11710 53170902
Stress urinary incontinence 11.20 9.90 23 166431 2244 53180368
Aplastic anaemia 11.17 9.90 6 166448 8315 53174297
Oesophagogastroduodenoscopy 11.16 9.90 6 166448 111 53182501
Ligament pain 11.15 9.90 7 166447 175 53182437
Low birth weight baby 11.12 9.90 3 166451 6334 53176278
Microscopic polyangiitis 11.12 9.90 7 166447 176 53182436
Product taste abnormal 11.11 9.90 22 166432 2091 53180521
Product dispensing error 11.06 9.90 62 166392 10178 53172434
Peak expiratory flow rate increased 11.04 9.90 3 166451 6 53182606
Osteonecrosis 11.04 9.90 44 166410 26531 53156081
Ligament sprain 11.01 9.90 66 166388 11100 53171512
Animal scratch 11.00 9.90 14 166440 911 53181701
Hyperbilirubinaemia 10.95 9.90 11 166443 11058 53171554
Plasma cell myeloma 10.94 9.90 96 166358 47778 53134834
Depressed mood 10.91 9.90 169 166285 36795 53145817
Neoplasm malignant 10.88 9.90 42 166412 25559 53157053
Rhinitis perennial 10.86 9.90 4 166450 28 53182584
Device expulsion 10.78 9.90 52 166402 29761 53152851
Antibody test negative 10.74 9.90 4 166450 29 53182583
Inhalation therapy 10.74 9.90 5 166449 67 53182545
Infusion site warmth 10.73 9.90 18 166436 1504 53181108
School refusal 10.73 9.90 3 166451 7 53182605
Cytokine release syndrome 10.72 9.90 6 166448 8123 53174489
Device delivery system issue 10.69 9.90 11 166443 567 53182045
Snoring 10.69 9.90 31 166423 3761 53178851
Poisoning deliberate 10.69 9.90 7 166447 8706 53173906
Painful respiration 10.68 9.90 25 166429 2665 53179947
Conjunctivitis allergic 10.68 9.90 13 166441 808 53181804
Dyskinesia 10.67 9.90 57 166397 31776 53150836
Hypertensive crisis 10.67 9.90 18 166436 14488 53168124
Prothrombin time prolonged 10.62 9.90 9 166445 9813 53172799
Renal tubular necrosis 10.57 9.90 12 166442 11407 53171205
Cold urticaria 10.51 9.90 4 166450 31 53182581
Alice in wonderland syndrome 10.51 9.90 4 166450 31 53182581
Depressive symptom 10.50 9.90 28 166426 3236 53179376
Contusion 10.50 9.90 434 166020 110298 53072314
Intestinal perforation 10.49 9.90 12 166442 11368 53171244
Herpes zoster oticus 10.49 9.90 8 166446 276 53182336
Sleep disorder 10.45 9.90 249 166205 58621 53123991
Abortion induced 10.44 9.90 11 166443 10815 53171797
Injection site hypoaesthesia 10.43 9.90 9 166445 371 53182241
Distal intestinal obstruction syndrome 10.38 9.90 10 166444 476 53182136
Systemic mastocytosis 10.33 9.90 7 166447 200 53182412
Neuropathy peripheral 10.33 9.90 244 166210 102943 53079669
Encephalitis 10.28 9.90 6 166448 7938 53174674
Cushingoid 10.22 9.90 47 166407 7135 53175477
Dyslipidaemia 10.22 9.90 43 166411 6284 53176328
Erysipelas 10.20 9.90 5 166449 7296 53175316
Attention deficit hyperactivity disorder 10.19 9.90 24 166430 2568 53180044
Quarantine 10.19 9.90 4 166450 34 53182578
PO2 decreased 10.18 9.90 18 166436 1569 53181043
Vasomotor rhinitis 10.18 9.90 5 166449 76 53182536
Female sterilisation 10.14 9.90 11 166443 603 53182009
Pertussis 10.11 9.90 11 166443 605 53182007
Diffuse large B-cell lymphoma 10.10 9.90 4 166450 6621 53175991
Dermatitis exfoliative 10.06 9.90 3 166451 5933 53176679
Fungal pharyngitis 10.06 9.90 5 166449 78 53182534
Glossitis 10.06 9.90 26 166428 2950 53179662
Therapeutic response unexpected 10.06 9.90 90 166364 17180 53165432
Flushing 10.04 9.90 290 166164 70310 53112302
Administration site bruise 10.03 9.90 8 166446 295 53182317
Breast neoplasm 10.01 9.90 17 166437 1435 53181177
Pneumonitis 9.98 9.90 56 166398 30832 53151780
Blood urea increased 9.93 9.90 45 166409 26186 53156426
Hospitalisation 9.91 9.90 291 166163 70721 53111891
Cerebral haemorrhage 9.90 9.90 54 166400 29942 53152670
Allergic respiratory disease 9.90 9.90 4 166450 37 53182575
Chronic kidney disease 9.90 9.90 87 166367 43283 53139329

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 3184.48 10.65 1638 66410 42427 32403051
Wheezing 1040.59 10.65 752 67296 36122 32409356
Eosinophilic granulomatosis with polyangiitis 853.66 10.65 251 67797 1241 32444237
Obstructive airways disorder 564.91 10.65 337 67711 11624 32433854
Forced expiratory volume decreased 394.73 10.65 178 67870 3378 32442100
Cough 379.43 10.65 872 67176 137945 32307533
Suicidal ideation 361.91 10.65 422 67626 37661 32407817
Sleep terror 356.28 10.65 113 67935 750 32444728
Abnormal behaviour 329.30 10.65 338 67710 26128 32419350
Blood count abnormal 293.92 10.65 232 67816 12694 32432784
Aggression 291.47 10.65 385 67663 39004 32406474
Productive cough 284.74 10.65 354 67694 33762 32411716
Dyspnoea 281.34 10.65 1493 66555 360552 32084926
Nightmare 252.46 10.65 214 67834 12952 32432526
Toxicity to various agents 222.97 10.65 50 67998 177991 32267487
Anger 221.12 10.65 190 67858 11714 32433764
Nasal congestion 219.56 10.65 241 67807 20110 32425368
Therapeutic product effect incomplete 210.93 10.65 339 67709 41002 32404476
Sleep disorder due to a general medical condition 208.73 10.65 113 67935 3221 32442257
Sputum discoloured 206.85 10.65 152 67896 7464 32438014
Sinusitis 199.23 10.65 309 67739 36251 32409227
Middle insomnia 195.76 10.65 138 67910 6346 32439132
Chest discomfort 192.46 10.65 363 67685 49867 32395611
Acute kidney injury 165.39 10.65 224 67824 293244 32152234
Nasal polyps 150.05 10.65 75 67973 1805 32443673
Anaemia 145.82 10.65 152 67896 223472 32222006
Blood immunoglobulin E increased 140.82 10.65 74 67974 1983 32443495
Anxiety 133.43 10.65 473 67575 95532 32349946
Depression 130.46 10.65 473 67575 96587 32348891
Pulmonary function test decreased 129.95 10.65 97 67951 4878 32440600
Mood altered 127.83 10.65 123 67925 8781 32436697
Crying 125.84 10.65 102 67946 5794 32439684
Loss of personal independence in daily activities 120.67 10.65 208 67840 26625 32418853
Death 118.02 10.65 409 67639 382108 32063370
Urticaria 111.21 10.65 325 67723 59289 32386189
Nasopharyngitis 109.79 10.65 338 67710 63449 32382029
Febrile neutropenia 104.82 10.65 60 67988 119506 32325972
Infective pulmonary exacerbation of cystic fibrosis 103.50 10.65 109 67939 8670 32436808
Eosinophilia 102.59 10.65 186 67862 24772 32420706
Thrombocytopenia 102.07 10.65 96 67952 148203 32297275
Drug interaction 100.56 10.65 190 67858 217995 32227483
Rhinorrhoea 97.92 10.65 174 67874 22812 32422666
Asthmatic crisis 92.54 10.65 38 68010 567 32444911
Eosinophil count increased 91.91 10.65 100 67948 8255 32437223
Dyspnoea exertional 90.21 10.65 230 67818 38731 32406747
Bronchial wall thickening 87.49 10.65 42 68006 923 32444555
Bronchospasm 87.05 10.65 111 67937 10844 32434634
Chronic obstructive pulmonary disease 85.41 10.65 260 67788 48493 32396985
Sleep disorder 85.14 10.65 179 67869 26573 32418905
Influenza 83.06 10.65 248 67800 45766 32399712
Bronchitis 80.96 10.65 230 67818 41277 32404201
Irritability 79.67 10.65 166 67882 24488 32420990
Bronchial hyperreactivity 78.37 10.65 46 68002 1536 32443942
Pancytopenia 76.82 10.65 48 68000 91187 32354291
Tic 76.12 10.65 50 67998 2044 32443434
Gastrooesophageal reflux disease 75.21 10.65 200 67848 34538 32410940
Bronchial obstruction 74.84 10.65 46 68002 1673 32443805
Eosinophilic pneumonia chronic 74.76 10.65 23 68025 136 32445342
Hypotension 73.42 10.65 221 67827 215889 32229589
Neutropenia 72.53 10.65 116 67932 142059 32303419
Screaming 72.38 10.65 42 68006 1372 32444106
Mood swings 71.72 10.65 87 67961 8078 32437400
Rhinitis 69.56 10.65 69 67979 5112 32440366
Sensitivity to weather change 68.91 10.65 42 68006 1504 32443974
Blood creatinine increased 68.75 10.65 60 67988 96072 32349406
Hypersensitivity 68.02 10.65 270 67778 57488 32387990
Vital capacity decreased 67.93 10.65 28 68020 422 32445056
Upper-airway cough syndrome 67.78 10.65 55 67993 3128 32442350
Psychomotor hyperactivity 67.77 10.65 89 67959 8950 32436528
Breath sounds abnormal 65.88 10.65 72 67976 5973 32439505
Malignant neoplasm progression 65.11 10.65 42 68006 78454 32367024
Full blood count abnormal 64.64 10.65 52 67996 2921 32442557
Ear infection 64.61 10.65 84 67964 8364 32437114
Renal failure 63.73 10.65 115 67933 134363 32311115
Multiple organ dysfunction syndrome 62.70 10.65 34 68014 69820 32375658
Seasonal allergy 62.57 10.65 66 67982 5258 32440220
Headache 61.45 10.65 654 67394 195543 32249935
Drug abuse 61.20 10.65 47 68001 80196 32365282
Bronchial secretion retention 60.85 10.65 34 68014 1032 32444446
Sepsis 60.16 10.65 154 67894 158680 32286798
Dysplastic naevus 59.98 10.65 25 68023 388 32445090
Allergy to animal 59.77 10.65 22 68026 240 32445238
Pulmonary function test abnormal 59.74 10.65 43 68005 2043 32443435
Heart rate increased 59.66 10.65 208 67840 41620 32403858
Bronchopulmonary aspergillosis allergic 58.97 10.65 28 68020 600 32444878
Lower respiratory tract infection 58.93 10.65 164 67884 29079 32416399
Solar lentigo 58.40 10.65 25 68023 416 32445062
Photodermatosis 58.38 10.65 26 68022 478 32445000
Bronchiectasis 57.38 10.65 72 67976 6920 32438558
Blood pressure systolic increased 57.21 10.65 118 67930 17278 32428200
Upper respiratory tract infection 57.15 10.65 163 67885 29310 32416168
Haemoglobin decreased 56.99 10.65 102 67946 119569 32325909
Off label use 56.73 10.65 392 67656 305928 32139550
Hyponatraemia 56.37 10.65 44 68004 74469 32371009
Educational problem 56.37 10.65 25 68023 455 32445023
Confusional state 56.35 10.65 136 67912 142979 32302499
Vocal cord dysfunction 56.34 10.65 20 68028 195 32445283
Leukopenia 55.82 10.65 28 68020 60094 32385384
Social avoidant behaviour 55.24 10.65 49 67999 3150 32442328
Blood pressure increased 54.82 10.65 318 67730 79036 32366442
Sneezing 54.45 10.65 58 67990 4673 32440805
Nasal disorder 53.89 10.65 36 68012 1514 32443964
Respiratory tract congestion 52.59 10.65 63 67985 5773 32439705
Anaphylactic reaction 51.97 10.65 160 67888 30012 32415466
Dyspnoea at rest 51.25 10.65 48 68000 3311 32442167
Aspirin-exacerbated respiratory disease 48.74 10.65 22 68026 418 32445060
Victim of child abuse 47.51 10.65 26 68022 757 32444721
Rhabdomyolysis 46.85 10.65 43 68005 67222 32378256
Suffocation feeling 46.85 10.65 24 68024 609 32444869
Body temperature decreased 46.41 10.65 83 67965 10931 32434547
Septic shock 45.84 10.65 46 68002 68943 32376535
Dehydration 45.81 10.65 129 67919 128829 32316649
Insomnia 44.73 10.65 361 67687 99987 32345491
Personality change 44.58 10.65 54 67994 5005 32440473
Depressed mood 44.39 10.65 110 67938 18190 32427288
Blood cholesterol 44.10 10.65 16 68032 167 32445311
Product quality issue 43.93 10.65 113 67935 19120 32426358
Platelet count decreased 43.44 10.65 111 67937 114480 32330998
Emotional disorder 43.02 10.65 55 67993 5386 32440092
Eye swelling 42.75 10.65 74 67974 9498 32435980
Forced vital capacity decreased 42.32 10.65 24 68024 750 32444728
Eosinophil count 41.48 10.65 15 68033 155 32445323
Renal impairment 41.47 10.65 81 67967 91891 32353587
Diarrhoea 40.81 10.65 529 67519 364273 32081205
Completed suicide 40.41 10.65 83 67965 92434 32353044
Sleep apnoea syndrome 40.38 10.65 108 67940 18706 32426772
Panic attack 39.29 10.65 70 67978 9191 32436287
Right atrial hypertrophy 37.76 10.65 17 68031 321 32445157
Anosmia 37.74 10.65 34 68014 2231 32443247
Eye pruritus 37.67 10.65 47 68001 4491 32440987
Restrictive pulmonary disease 37.52 10.65 26 68022 1162 32444316
Chronic sinusitis 37.44 10.65 31 68017 1814 32443664
Foetal exposure during pregnancy 37.20 10.65 20 68028 41281 32404197
Gastrointestinal haemorrhage 37.06 10.65 79 67969 86803 32358675
Multiple allergies 37.01 10.65 34 68014 2288 32443190
Rheumatoid arthritis 36.69 10.65 24 68024 44520 32400958
Cardiac arrest 36.47 10.65 94 67954 96682 32348796
Respiratory rate increased 36.25 10.65 68 67980 9289 32436189
Food allergy 35.70 10.65 24 68024 1020 32444458
Respiratory disorder 35.34 10.65 105 67943 19312 32426166
Nasal inflammation 35.24 10.65 15 68033 246 32445232
Bone marrow failure 35.15 10.65 10 68038 30394 32415084
Oropharyngeal pain 34.84 10.65 144 67904 31208 32414270
Reversible airways obstruction 34.21 10.65 16 68032 331 32445147
Nasal oedema 33.86 10.65 16 68032 339 32445139
Disease progression 33.79 10.65 83 67965 86779 32358699
Stress 33.67 10.65 118 67930 23664 32421814
Negative thoughts 33.51 10.65 20 68028 689 32444789
Sputum increased 33.15 10.65 31 68017 2134 32443344
Respiratory tract infection 32.85 10.65 95 67953 17210 32428268
Hyperkalaemia 32.69 10.65 60 67988 69690 32375788
Sinus congestion 32.62 10.65 46 68002 4949 32440529
Morbid thoughts 32.38 10.65 14 68034 239 32445239
Cardio-respiratory arrest 32.13 10.65 42 68006 55947 32389531
Myocardial infarction 31.78 10.65 145 67903 125531 32319947
Eye disorder 31.77 10.65 61 67987 8479 32436999
Hypoventilation 31.62 10.65 37 68011 3307 32442171
Obstruction 31.34 10.65 28 68020 1817 32443661
Pruritus 31.33 10.65 409 67639 128293 32317185
Ascites 31.32 10.65 23 68025 40168 32405310
Nasal discharge discolouration 31.06 10.65 14 68034 265 32445213
Cardiac failure 30.87 10.65 94 67954 91579 32353899
Peak expiratory flow rate decreased 30.85 10.65 12 68036 154 32445324
Status asthmaticus 30.66 10.65 15 68033 344 32445134
Excessive eye blinking 30.50 10.65 16 68032 427 32445051
Malaise 29.98 10.65 529 67519 176609 32268869
Homicidal ideation 29.34 10.65 32 68016 2648 32442830
Asthma-chronic obstructive pulmonary disease overlap syndrome 29.26 10.65 21 68027 993 32444485
Smoke sensitivity 28.92 10.65 12 68036 184 32445294
Attention deficit hyperactivity disorder 28.84 10.65 29 68019 2183 32443295
Pleural effusion 28.79 10.65 78 67970 78914 32366564
Product dose omission issue 28.41 10.65 334 67714 102241 32343237
Suicidal behaviour 28.37 10.65 24 68024 1447 32444031
Throat tightness 28.31 10.65 55 67993 7711 32437767
Lung hyperinflation 28.24 10.65 20 68028 926 32444552
Blood immunoglobulin G decreased 28.02 10.65 22 68026 1193 32444285
Blebitis 27.97 10.65 6 68042 4 32445474
Blood test abnormal 27.75 10.65 48 68000 6156 32439322
Product substitution issue 27.74 10.65 65 67983 10371 32435107
Coma 27.63 10.65 29 68019 42583 32402895
Rhinitis allergic 27.61 10.65 33 68015 3016 32442462
Endocarditis fibroplastica 27.40 10.65 6 68042 5 32445473
General physical health deterioration 27.37 10.65 136 67912 115123 32330355
Attention-seeking behaviour 27.29 10.65 8 68040 39 32445439
Eczema 27.25 10.65 81 67967 14899 32430579
Tearfulness 27.23 10.65 25 68023 1681 32443797
Nasal discomfort 27.17 10.65 22 68026 1247 32444231
Hepatic failure 27.06 10.65 21 68027 35659 32409819
Dust allergy 26.86 10.65 16 68032 549 32444929
Perfume sensitivity 26.70 10.65 10 68038 115 32445363
Agranulocytosis 26.63 10.65 8 68040 23469 32422009
Total lung capacity abnormal 26.55 10.65 11 68037 168 32445310
Acute myocardial infarction 26.23 10.65 47 68001 55102 32390376
Dermatitis atopic 26.21 10.65 29 68019 2438 32443040
Intentional overdose 26.21 10.65 29 68019 41572 32403906
Osteoporosis 26.21 10.65 70 67978 12112 32433366
Hypokalaemia 26.16 10.65 47 68001 55047 32390431
Secretion discharge 25.84 10.65 38 68010 4248 32441230
Hypereosinophilic syndrome 25.76 10.65 12 68036 246 32445232
Drug resistance 25.73 10.65 8 68040 22957 32422521
Snoring 25.62 10.65 32 68016 3061 32442417
Haematemesis 25.45 10.65 13 68035 27622 32417856
Delirium 25.31 10.65 33 68015 44013 32401465
Panic reaction 25.26 10.65 23 68025 1530 32443948
Sinus polyp 25.06 10.65 11 68037 195 32445283
Pleural thickening 24.81 10.65 13 68035 346 32445132
Pneumonia 24.70 10.65 942 67106 354310 32091168
Pigment dispersion syndrome 24.46 10.65 6 68042 12 32445466
Self-injurious ideation 24.26 10.65 23 68025 1611 32443867
Chronic spontaneous urticaria 24.07 10.65 9 68039 103 32445375
Eosinophilic bronchitis 24.06 10.65 10 68038 154 32445324
International normalised ratio increased 24.04 10.65 41 68007 48994 32396484
Dysphonia 23.77 10.65 96 67952 20588 32424890
Neuroleptic malignant syndrome 23.77 10.65 4 68044 17491 32427987
Cystic fibrosis 23.75 10.65 27 68021 2339 32443139
Blood lactic acid 23.55 10.65 13 68035 385 32445093
Sputum purulent 23.26 10.65 14 68034 490 32444988
Peritonitis 22.92 10.65 9 68039 22321 32423157
Throat irritation 22.90 10.65 58 67990 9720 32435758
Enuresis 22.82 10.65 25 68023 2079 32443399
Meningitis eosinophilic 22.75 10.65 6 68042 18 32445460
Bronchiolitis obliterans syndrome 22.60 10.65 10 68038 181 32445297
Polyp 22.43 10.65 32 68016 3480 32441998
Fear 22.32 10.65 63 67985 11256 32434222
Cerebral haemorrhage 22.13 10.65 24 68024 34723 32410755
C-reactive protein increased 21.98 10.65 42 68006 48060 32397418
Cytomegalovirus infection 21.97 10.65 13 68035 25451 32420027
Lower respiratory tract congestion 21.96 10.65 19 68029 1181 32444297
Metabolic acidosis 21.87 10.65 32 68016 40667 32404811
NPM1 gene mutation 21.87 10.65 9 68039 135 32445343
Illness 21.76 10.65 43 68005 6103 32439375
Sinus disorder 21.76 10.65 45 68003 6599 32438879
Acute respiratory distress syndrome 21.63 10.65 13 68035 25240 32420238
Temperature intolerance 21.58 10.65 30 68018 3185 32442293
Right ventricular hypertrophy 21.57 10.65 17 68031 927 32444551
Electrocardiogram QT prolonged 21.47 10.65 31 68017 39610 32405868
Mucosal inflammation 21.40 10.65 23 68025 33411 32412067
Oesophageal polyp 21.27 10.65 7 68041 53 32445425
Nausea 21.12 10.65 511 67537 320338 32125140
Syncope 21.01 10.65 107 67941 90017 32355461
Physical assault 21.01 10.65 18 68030 1104 32444374
Melaena 20.93 10.65 25 68023 34640 32410838
Mast cell activation syndrome 20.90 10.65 9 68039 152 32445326
Pyrexia 20.67 10.65 511 67537 319457 32126021
Urinary tract infection 20.45 10.65 92 67956 79979 32365499
Encephalopathy 20.37 10.65 25 68023 34232 32411246
Hyperkaliuria 20.33 10.65 9 68039 163 32445315
Deep vein thrombosis 20.27 10.65 67 67981 63646 32381832
Cardiogenic shock 20.13 10.65 9 68039 20653 32424825
Tubulointerstitial nephritis 19.91 10.65 8 68040 19569 32425909
Blood urea increased 19.78 10.65 23 68025 32250 32413228
Self esteem decreased 19.65 10.65 13 68035 538 32444940
Bradycardia 19.64 10.65 80 67968 71482 32373996
Allergic respiratory disease 19.57 10.65 6 68042 35 32445443
Affective disorder 19.41 10.65 30 68018 3503 32441975
Blood bilirubin increased 19.40 10.65 32 68016 38752 32406726
Cortisol decreased 19.36 10.65 16 68032 934 32444544
Discomfort 19.35 10.65 75 67973 15780 32429698
Eosinophilic oesophagitis 19.30 10.65 10 68038 260 32445218
Child abuse 19.27 10.65 11 68037 348 32445130
Cerebrovascular accident 19.27 10.65 104 67944 86216 32359262
Gastroenteritis viral 19.23 10.65 41 68007 6142 32439336
Scleroderma 19.22 10.65 19 68029 1401 32444077
White blood cell count decreased 19.21 10.65 112 67936 91086 32354392
Contraindicated product administered 19.07 10.65 8 68040 19068 32426410
Hepatocellular injury 19.07 10.65 15 68033 25303 32420175
Lung hernia 19.05 10.65 7 68041 76 32445402
Rhinitis perennial 18.97 10.65 8 68040 128 32445350
Palmar-plantar erythrodysaesthesia syndrome 18.54 10.65 5 68043 15744 32429734
Stomatitis 18.49 10.65 35 68013 40194 32405284
Neoplasm progression 18.47 10.65 9 68039 19649 32425829
Lactic acidosis 18.38 10.65 26 68022 33510 32411968
Neutrophil count decreased 18.35 10.65 45 68003 47094 32398384
Steroid diabetes 18.35 10.65 21 68027 1832 32443646
Rhonchi 18.27 10.65 21 68027 1841 32443637
Oropharyngeal discomfort 18.26 10.65 23 68025 2219 32443259
Abnormal dreams 18.21 10.65 49 67999 8515 32436963
Alopecia areata 18.18 10.65 9 68039 212 32445266
Hypoglycaemia 18.12 10.65 56 67992 54326 32391152
Altered state of consciousness 17.91 10.65 12 68036 21985 32423493
Bronchiolitis 17.81 10.65 26 68022 2887 32442591
Growth retardation 17.72 10.65 20 68028 1719 32443759
Acute myeloid leukaemia 17.68 10.65 9 68039 19165 32426313
Respiratory tract irritation 17.58 10.65 8 68040 155 32445323
Epidural lipomatosis 17.58 10.65 13 68035 644 32444834
Behaviour disorder 17.48 10.65 29 68019 3595 32441883
Hypohidrosis 17.48 10.65 9 68039 231 32445247
Mononeuropathy multiplex 17.44 10.65 8 68040 158 32445320
Asthenia 17.42 10.65 369 67679 235575 32209903
Impaired quality of life 17.32 10.65 23 68025 2337 32443141
Pneumocystis jirovecii pneumonia 17.19 10.65 9 68039 18861 32426617
Hyperglycaemia 17.12 10.65 34 68014 38357 32407121
Mental disorder 17.10 10.65 68 67980 14480 32430998
Upper respiratory tract congestion 17.09 10.65 14 68034 807 32444671
Chimerism 17.03 10.65 9 68039 244 32445234
Migraine 16.95 10.65 66 67982 13919 32431559
Hyperbilirubinaemia 16.84 10.65 8 68040 17722 32427756
Feeling abnormal 16.82 10.65 197 67851 60226 32385252
Bronchitis viral 16.73 10.65 9 68039 253 32445225
Disturbance in social behaviour 16.71 10.65 19 68029 1646 32443832
Haematuria 16.69 10.65 49 67999 48312 32397166
Nocturnal dyspnoea 16.69 10.65 12 68036 569 32444909
Neurodevelopmental disorder 16.66 10.65 8 68040 176 32445302
Unresponsive to stimuli 16.57 10.65 20 68028 27589 32417889
Asthma exercise induced 16.43 10.65 7 68041 115 32445363
Respiratory symptom 16.21 10.65 15 68033 1019 32444459
Ocular discomfort 16.17 10.65 19 68029 1705 32443773
Hostility 16.14 10.65 14 68034 873 32444605
Constipation 16.05 10.65 178 67870 126195 32319283
Weight increased 16.00 10.65 255 67793 83408 32362070
Disseminated intravascular coagulation 15.91 10.65 15 68033 23161 32422317
Idiopathic intracranial hypertension 15.84 10.65 12 68036 617 32444861
Device related infection 15.69 10.65 9 68039 17924 32427554
Treatment failure 15.55 10.65 37 68011 39126 32406352
Exophthalmos congenital 15.51 10.65 3 68045 0 32445478
Seizure anoxic 15.51 10.65 3 68045 0 32445478
Cephalo-pelvic disproportion 15.51 10.65 3 68045 0 32445478
Pigmentary glaucoma 15.51 10.65 3 68045 0 32445478
Separation anxiety disorder 15.51 10.65 3 68045 0 32445478
Stiff person syndrome 15.32 10.65 7 68041 137 32445341
Circulatory collapse 15.31 10.65 13 68035 21112 32424366
Sopor 15.28 10.65 3 68045 11746 32433732
Human ehrlichiosis 15.20 10.65 8 68040 215 32445263
Allergy to plants 15.17 10.65 4 68044 12 32445466
Small airways disease 15.06 10.65 5 68043 39 32445439
Neuropsychiatric symptoms 15.04 10.65 11 68037 536 32444942
Vasculitis 14.87 10.65 46 68002 8647 32436831
Frustration tolerance decreased 14.79 10.65 21 68027 2273 32443205
Total lung capacity decreased 14.76 10.65 12 68036 684 32444794
Alanine aminotransferase increased 14.66 10.65 100 67948 78379 32367099
Nasal septum deviation 14.59 10.65 14 68034 995 32444483
Airway remodelling 14.37 10.65 7 68041 159 32445319
Bone density decreased 14.37 10.65 19 68029 1923 32443555
Swelling face 14.12 10.65 88 67960 22417 32423061
Kidney infection 14.06 10.65 32 68016 5009 32440469
Sedation 13.92 10.65 11 68037 18515 32426963
Angina pectoris 13.87 10.65 28 68020 31398 32414080
Nasal mucosal disorder 13.74 10.65 6 68042 105 32445373
Hepatic encephalopathy 13.72 10.65 7 68041 14888 32430590
Stridor 13.71 10.65 21 68027 2433 32443045
Depressed level of consciousness 13.65 10.65 42 68006 40805 32404673
Weight decreased 13.61 10.65 446 67602 164372 32281106
Oedema peripheral 13.59 10.65 163 67885 113928 32331550
Extrapyramidal disorder 13.59 10.65 4 68044 11891 32433587
Fall 13.56 10.65 310 67738 195891 32249587
Sputum abnormal 13.53 10.65 10 68038 495 32444983
Agitation 13.53 10.65 181 67867 57055 32388423
Forced expiratory flow decreased 13.48 10.65 7 68041 183 32445295
Hemiparesis 13.41 10.65 8 68040 15599 32429879
Vomiting 13.39 10.65 383 67665 235174 32210304
Tonsillar disorder 13.39 10.65 6 68042 112 32445366
Sputum retention 13.32 10.65 10 68038 507 32444971
Shock haemorrhagic 13.27 10.65 3 68045 10642 32434836
Prolonged expiration 13.24 10.65 7 68041 190 32445288
Decreased appetite 13.20 10.65 247 67801 160566 32284912
Diabetic ketoacidosis 13.04 10.65 11 68037 17921 32427557
Chest X-ray abnormal 12.93 10.65 27 68021 3986 32441492
Peritonitis bacterial 12.88 10.65 5 68043 12491 32432987
Onychophagia 12.87 10.65 5 68043 64 32445414
Subarachnoid haemorrhage 12.84 10.65 3 68045 10408 32435070
Nervousness 12.84 10.65 56 67992 12423 32433055
Hypogammaglobulinaemia 12.79 10.65 35 68013 6141 32439337
Drug level increased 12.64 10.65 14 68034 20066 32425412
Pulmonary embolism 12.64 10.65 113 67935 83546 32361932
Renal tubular necrosis 12.63 10.65 9 68039 15969 32429509
Haematochezia 12.62 10.65 41 68007 39167 32406311
Hepatocellular carcinoma 12.59 10.65 3 68045 10267 32435211
Fight in school 12.58 10.65 3 68045 5 32445473
Central obesity 12.58 10.65 10 68038 552 32444926
Subdural haematoma 12.47 10.65 14 68034 19939 32425539
Liver function test decreased 12.46 10.65 5 68043 70 32445408
Graft versus host disease in lung 12.46 10.65 10 68038 560 32444918
Dacryostenosis congenital 12.43 10.65 4 68044 28 32445450
Spirometry abnormal 12.38 10.65 9 68039 434 32445044
Throat clearing 12.38 10.65 8 68040 318 32445160
ACTH stimulation test abnormal 12.23 10.65 3 68045 6 32445472
Palpitations 12.20 10.65 122 67926 35847 32409631
Haemophilus infection 12.20 10.65 13 68035 1048 32444430
Product taste abnormal 12.17 10.65 14 68034 1228 32444250
Bronchial disorder 12.12 10.65 14 68034 1234 32444244
Hypercalcaemia 12.11 10.65 7 68041 13887 32431591
Episcleritis 12.09 10.65 6 68042 142 32445336
Breath holding 11.92 10.65 3 68045 7 32445471
Pulmonary oedema 11.90 10.65 53 67995 46214 32399264
Head banging 11.87 10.65 6 68042 148 32445330
Respiration abnormal 11.84 10.65 22 68026 2983 32442495
Bronchopulmonary aspergillosis 11.79 10.65 7 68041 13680 32431798
Anuria 11.74 10.65 4 68044 10833 32434645
Dysphagia 11.64 10.65 78 67970 61398 32384080
Gastrointestinal tract mucosal pigmentation 11.53 10.65 8 68040 358 32445120
Hepatitis C 11.52 10.65 7 68041 13511 32431967
Obesity 11.49 10.65 47 68001 10135 32435343
Poor quality device used 11.47 10.65 13 68035 1122 32444356
Painful respiration 11.47 10.65 14 68034 1308 32444170
Choking 11.43 10.65 30 68018 5136 32440342
Clostridium difficile colitis 11.43 10.65 8 68040 14323 32431155
Eosinophil count abnormal 11.42 10.65 8 68040 364 32445114
Sialadenosis 11.37 10.65 3 68045 9 32445469
Aspartate aminotransferase increased 11.27 10.65 87 67961 66342 32379136
Aortic valve stenosis 11.20 10.65 18 68030 2174 32443304
Breech presentation 11.14 10.65 6 68042 169 32445309
Type III immune complex mediated reaction 11.14 10.65 7 68041 265 32445213
Rash erythematous 11.12 10.65 87 67961 23852 32421626
Actinic keratosis 11.11 10.65 25 68023 3885 32441593
Duodenal ulcer 11.09 10.65 4 68044 10451 32435027
Shock 11.06 10.65 21 68027 24093 32421385
Penile erythema 11.05 10.65 6 68042 172 32445306
Cerebral infarction 11.03 10.65 26 68022 27588 32417890
Haematocrit decreased 10.98 10.65 32 68016 31630 32413848
Liver disorder 10.97 10.65 32 68016 31622 32413856
Lymphocyte count decreased 10.96 10.65 17 68031 21102 32424376
Prostatomegaly 10.96 10.65 29 68019 4989 32440489
Drug intolerance 10.94 10.65 61 67987 50174 32395304
Deformity thorax 10.92 10.65 4 68044 43 32445435
Quality of life decreased 10.91 10.65 23 68025 3419 32442059
Pregnancy 10.90 10.65 7 68041 275 32445203
Hypomagnesaemia 10.89 10.65 14 68034 18791 32426687
Meralgia paraesthetica 10.83 10.65 6 68042 179 32445299
Pulmonary renal syndrome 10.74 10.65 6 68042 182 32445296
Somnambulism 10.71 10.65 22 68026 3210 32442268
Administration site irritation 10.71 10.65 3 68045 12 32445466

Pharmacologic Action:

SourceCodeDescription
ATC R03DC03 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Leukotriene receptor antagonists
ATC R03DC53 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Leukotriene receptor antagonists
FDA MoA N0000000083 Leukotriene Receptor Antagonists
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D065694 Cytochrome P-450 CYP1A2 Inducers
MeSH PA D006727 Hormone Antagonists
MeSH PA D020024 Leukotriene Antagonists
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
MeSH PA D019141 Respiratory System Agents
FDA EPC N0000175777 Leukotriene Receptor Antagonist
CHEBI has role CHEBI:38070 antiarrhythmic agent
CHEBI has role CHEBI:49159 LTRA
CHEBI has role CHEBI:49167 anti-asthmatic agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Allergic rhinitis indication 61582004
Non-allergic asthma indication 266361008 DOID:9360
Allergic asthma indication 389145006 DOID:9415
Asthma management indication 406162001
Exercise-Induced Bronchospasm Prevention indication
Suicidal thoughts contraindication 6471006
Hallucinations contraindication 7011001
Mood swings contraindication 18963009
Feeling agitated contraindication 24199005
Depressive disorder contraindication 35489007
Anxiety contraindication 48694002
Vasculitis of the skin contraindication 53312001
Dream disorder contraindication 85418005
Eosinophil count raised contraindication 386789004
Tremors contraindication
Nervousness contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.28 acidic
pKa2 4.98 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Cysteinyl leukotriene receptor 1 GPCR ANTAGONIST Ki 9.30 CHEMBL CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 5.83 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.57 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 5.40 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 5.58 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 5.71 DRUG MATRIX
Muscarinic acetylcholine receptor M3 GPCR Ki 5.85 DRUG MATRIX
Beta-3 adrenergic receptor GPCR Ki 5.50 DRUG MATRIX
Alpha-2C adrenergic receptor GPCR Ki 6.12 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.69 DRUG MATRIX
Adenosine receptor A3 GPCR Ki 6.61 DRUG MATRIX
Cytochrome P450 2C8 Enzyme Ki 5.96 WOMBAT-PK
Delta-type opioid receptor GPCR Ki 5.77 DRUG MATRIX
Arachidonate 5-lipoxygenase Enzyme Ki 4.33 WOMBAT-PK
Epidermal growth factor receptor Kinase IC50 5.50 DRUG MATRIX
Tyrosine-protein kinase Fyn Kinase IC50 5.33 DRUG MATRIX
Thromboxane-A synthase Enzyme IC50 5.82 DRUG MATRIX
Cysteinyl leukotriene receptor 2 GPCR Ki 5.30 PDSP
Mitogen-activated protein kinase 14 Kinase IC50 6.07 DRUG MATRIX
Substance-K receptor GPCR Ki 5.90 DRUG MATRIX
Uracil nucleotide/cysteinyl leukotriene receptor GPCR Ki 5.18 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.62 DRUG MATRIX
Cysteinyl leukotriene receptor 1 GPCR Ki 9.30 CHEMBL
Uracil nucleotide/cysteinyl leukotriene receptor GPCR ANTAGONIST IC50 7.21 IUPHAR

External reference:

IDSource
4024117 VUID
N0000022122 NUI
D00529 KEGG_DRUG
151767-02-1 SECONDARY_CAS_RN
4021110 VANDF
4024117 VANDF
C0298130 UMLSCUI
CHEBI:50730 CHEBI
MTK PDB_CHEM_ID
CHEMBL787 ChEMBL_ID
CHEMBL1200681 ChEMBL_ID
DB00471 DRUGBANK_ID
C093875 MESH_SUPPLEMENTAL_RECORD_UI
3340 IUPHAR_LIGAND_ID
7388 INN_ID
MHM278SD3E UNII
5281040 PUBCHEM_CID
115713 RXNORM
11578 MMSL
189710 MMSL
5134 MMSL
d04289 MMSL
007256 NDDF
007257 NDDF
108620002 SNOMEDCT_US
320883008 SNOMEDCT_US
373728005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Montelukast Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-7487 GRANULE 4 mg ORAL ANDA 31 sections
MONTELUKAST HUMAN PRESCRIPTION DRUG LABEL 1 0143-9649 TABLET, FILM COATED 10 mg ORAL ANDA 25 sections
MONTELUKAST HUMAN PRESCRIPTION DRUG LABEL 1 0143-9650 TABLET, CHEWABLE 5 mg ORAL ANDA 25 sections
MONTELUKAST HUMAN PRESCRIPTION DRUG LABEL 1 0143-9651 TABLET, CHEWABLE 4 mg ORAL ANDA 25 sections
Montelukast HUMAN PRESCRIPTION DRUG LABEL 1 0781-5554 TABLET, CHEWABLE 4 mg ORAL ANDA 28 sections
Montelukast HUMAN PRESCRIPTION DRUG LABEL 1 0781-5555 TABLET, CHEWABLE 5 mg ORAL ANDA 28 sections
Montelukast HUMAN PRESCRIPTION DRUG LABEL 1 0781-5560 TABLET, FILM COATED 10 mg ORAL ANDA 28 sections
Montelukast HUMAN PRESCRIPTION DRUG LABEL 1 0904-6808 TABLET, FILM COATED 10 mg ORAL ANDA 28 sections
Montelukast Sodium HUMAN PRESCRIPTION DRUG LABEL 1 13668-079 TABLET, CHEWABLE 4 mg ORAL ANDA 26 sections
Montelukast Sodium HUMAN PRESCRIPTION DRUG LABEL 1 13668-080 TABLET, CHEWABLE 5 mg ORAL ANDA 26 sections
Montelukast Sodium HUMAN PRESCRIPTION DRUG LABEL 1 13668-081 TABLET 10 mg ORAL ANDA 26 sections
MONTELUKAST SODIUM ORAL HUMAN PRESCRIPTION DRUG LABEL 1 13668-531 GRANULE 4 mg ORAL ANDA 19 sections
MONTELUKAST SODIUM ORAL HUMAN PRESCRIPTION DRUG LABEL 1 13668-531 GRANULE 4 mg ORAL ANDA 19 sections
Montelukast Sodium HUMAN PRESCRIPTION DRUG LABEL 1 16729-119 TABLET, FILM COATED 10 mg ORAL ANDA 28 sections
SINGULAIR HUMAN PRESCRIPTION DRUG LABEL 1 21695-221 TABLET, FILM COATED 10 mg ORAL NDA 28 sections
SINGULAIR HUMAN PRESCRIPTION DRUG LABEL 1 21695-565 TABLET, CHEWABLE 5 mg ORAL NDA 28 sections
MONTELUKAST SODIUM Human Prescription Drug Label 1 27241-015 GRANULE 4 mg ORAL ANDA 28 sections
MONTELUKAST SODIUM Human Prescription Drug Label 1 27241-016 TABLET, CHEWABLE 4 mg ORAL ANDA 28 sections
MONTELUKAST SODIUM Human Prescription Drug Label 1 27241-017 TABLET, CHEWABLE 5 mg ORAL ANDA 28 sections
MONTELUKAST SODIUM Human Prescription Drug Label 1 27241-018 TABLET, COATED 10 mg ORAL ANDA 28 sections
montelukast sodium HUMAN PRESCRIPTION DRUG LABEL 1 29300-220 TABLET, FILM COATED 10 mg ORAL ANDA 26 sections
montelukast sodium HUMAN PRESCRIPTION DRUG LABEL 1 29300-221 TABLET, CHEWABLE 4 mg ORAL ANDA 26 sections
montelukast sodium HUMAN PRESCRIPTION DRUG LABEL 1 29300-222 TABLET, CHEWABLE 5 mg ORAL ANDA 26 sections
Montelukast HUMAN PRESCRIPTION DRUG LABEL 1 31722-726 TABLET, FILM COATED 10 mg ORAL ANDA 28 sections
montelukast sodium HUMAN PRESCRIPTION DRUG LABEL 1 31722-727 TABLET, CHEWABLE 4 mg ORAL ANDA 28 sections
montelukast sodium HUMAN PRESCRIPTION DRUG LABEL 1 31722-728 TABLET, CHEWABLE 5 mg ORAL ANDA 28 sections
montelukast sodium HUMAN PRESCRIPTION DRUG LABEL 1 33261-969 TABLET, FILM COATED 10 mg ORAL ANDA 29 sections
Montelukast Human Prescription Drug Label 1 33342-102 TABLET 10 mg ORAL ANDA 28 sections
Montelukast sodium Human Prescription Drug Label 1 33342-110 TABLET, CHEWABLE 4 mg ORAL ANDA 28 sections
Montelukast sodium Human Prescription Drug Label 1 33342-111 TABLET, CHEWABLE 5 mg ORAL ANDA 28 sections