montelukast 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
leukotriene receptor antagonists 1836 158966-92-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • montelukast
  • montelukast sodium
  • singulair
Montelukast is an orally active compound that binds with high affinity and selectivity to the CysLT1 receptor (in preference to other pharmacologically important airway receptors, such as the prostanoid, cholinergic, or beta-adrenergic receptor). Montelukast inhibits physiologic actions of cysteinyl leukotriene LTD4 at the CysLT1 receptor without any agonist activity.
  • Molecular weight: 586.19
  • Formula: C35H36ClNO3S
  • CLOGP: 8.33
  • LIPINSKI: 2
  • HAC: 4
  • HDO: 2
  • TPSA: 70.42
  • ALOGS: -7.85
  • ROTB: 12
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.20 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.28 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 62 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.15 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.68 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.00 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 4.646 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 3.483 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.676 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 11.015 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 0.140 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 0.110 % High 1
herg hERG pIC50 4.750 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 11.614 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 14.825 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 0.310 % High 1
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,IKBKB,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 47
kinase-selectivity-class AXL,BRAF,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,MAP2K6,MAPK12,MAPK7,PDK4,STK33,TEK,ZAP70 14
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 2.168 High 1
mh-clint Mouse hepatocyte intrinsic clearance 17.219 High 1
mppb Mouse plasma protein binding (% unbound) 0.160 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 7.691 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
pppb Pig plasma protein binding (% unbound) 0.120 % High 1
rh-clint Rat hepatocyte intrinsic clearance 19.099 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 0.270 % High 1
rppb Rat plasma protein binding (% unbound) 0.140 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 1.189 uM High 1

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1998 FDA MERCK

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 6797.99 9.85 5755 273236 236405 90113051
Wheezing 2160.22 9.85 3132 275859 234948 90114508
Cough 1742.88 9.85 3637 275354 365325 89984131
Dyspnoea 1598.24 9.85 6125 272866 874830 89474626
Eosinophilic granulomatosis with polyangiitis 1424.31 9.85 460 278531 2070 90347386
Obstructive airways disorder 1184.42 9.85 825 278166 25044 90324412
Pemphigus 956.56 9.85 9 278982 326855 90022601
Full blood count abnormal 913.26 9.85 816 278175 35781 90313675
Sputum discoloured 883.96 9.85 629 278362 19762 90329694
Synovitis 853.99 9.85 38 278953 329714 90019742
Hand deformity 845.51 9.85 13 278978 296349 90053107
Productive cough 830.62 9.85 1103 277888 75960 90273496
Systemic lupus erythematosus 777.27 9.85 99 278892 361797 89987659
Chest discomfort 775.08 9.85 1467 277524 136898 90212558
Glossodynia 755.54 9.85 63 278928 321716 90027740
Pericarditis 699.81 9.85 31 278960 270120 90079336
Anti-cyclic citrullinated peptide antibody positive 693.98 9.85 6 278985 236427 90113029
Rhinitis allergic 689.16 9.85 501 278490 16284 90333172
Duodenal ulcer perforation 662.76 9.85 3 278988 221285 90128171
Sleep disorder due to a general medical condition 647.68 9.85 743 278248 43995 90305461
Nasal polyps 620.83 9.85 398 278593 10482 90338974
Arthropathy 620.64 9.85 179 278812 366063 89983393
Impaired quality of life 613.24 9.85 534 278457 22610 90326846
Forced expiratory volume decreased 612.50 9.85 317 278674 5491 90343965
Helicobacter infection 608.10 9.85 20 278971 226830 90122626
Nasal congestion 599.68 9.85 987 278004 82427 90267029
Wound 559.66 9.85 124 278867 302856 90046600
Folliculitis 544.25 9.85 19 278972 204334 90145122
Food allergy 529.21 9.85 513 278478 24965 90324491
Muscle injury 511.29 9.85 6 278985 176648 90172808
Respiratory tract infection 506.44 9.85 758 278233 58320 90291136
Pneumonia 498.53 9.85 3514 275477 634545 89714911
Chronic obstructive pulmonary disease 492.59 9.85 845 278146 72984 90276472
Upper respiratory tract infection 491.09 9.85 1165 277826 127153 90222303
Rheumatoid factor positive 483.24 9.85 9 278982 171641 90177815
Impaired healing 481.53 9.85 73 278918 234126 90115330
Rheumatic fever 444.03 9.85 5 278986 153116 90196340
Stomatitis 418.43 9.85 161 278830 274537 90074919
Upper-airway cough syndrome 416.73 9.85 357 278634 14778 90334678
Alopecia 413.14 9.85 552 278439 494519 89854937
Liver injury 403.98 9.85 32 278959 170535 90178921
Bronchitis 390.83 9.85 1196 277795 151731 90197725
Middle insomnia 389.36 9.85 359 278632 16392 90333064
General physical health deterioration 376.23 9.85 324 278667 354791 89994665
Irritable bowel syndrome 374.76 9.85 89 278902 207359 90142097
Temperature regulation disorder 359.51 9.85 323 278668 14256 90335200
Nasal oedema 353.89 9.85 232 278759 6352 90343104
Blood immunoglobulin E increased 353.70 9.85 201 278790 4224 90345232
Toxicity to various agents 349.38 9.85 228 278763 287618 90061838
Therapeutic product effect decreased 346.32 9.85 213 278778 277358 90072098
Maternal exposure during pregnancy 345.70 9.85 359 278632 359704 89989752
C-reactive protein abnormal 338.69 9.85 12 278979 127417 90222039
Abdominal discomfort 337.87 9.85 595 278396 476733 89872723
Breath sounds abnormal 336.93 9.85 319 278672 15067 90334389
Contraindicated product administered 322.46 9.85 306 278685 319833 90029623
Nightmare 319.75 9.85 364 278627 21361 90328095
Dyspnoea exertional 319.43 9.85 695 278296 71593 90277863
Blister 314.88 9.85 198 278793 254800 90094656
Anaphylactic reaction 313.71 9.85 775 278216 86749 90262707
Dermatitis atopic 311.65 9.85 373 278618 23099 90326357
Rhinorrhoea 306.02 9.85 772 278219 87544 90261912
Sleep apnoea syndrome 303.52 9.85 429 278562 31318 90318138
Drug intolerance 303.28 9.85 573 278418 447018 89902438
Product dose omission issue 293.22 9.85 1714 277277 289973 90059483
Influenza 290.85 9.85 1017 277974 138247 90211209
Asthmatic crisis 287.71 9.85 133 278858 1777 90347679
Urticaria 287.25 9.85 1795 277196 310939 90038517
Joint range of motion decreased 279.35 9.85 42 278949 135601 90213855
Joint swelling 271.21 9.85 730 278261 502570 89846886
Facet joint syndrome 269.67 9.85 7 278984 98382 90251074
Psoriatic arthropathy 268.78 9.85 187 278804 228148 90121308
Illness 267.95 9.85 701 278290 81268 90268188
C-reactive protein increased 266.81 9.85 112 278879 181277 90168179
Confusional state 262.79 9.85 493 278498 385712 89963744
Pulmonary function test abnormal 261.81 9.85 140 278851 2599 90346857
Eosinophil count increased 261.56 9.85 258 278733 12823 90336633
Infusion related reaction 258.87 9.85 561 278430 416219 89933237
Immunodeficiency 257.56 9.85 471 278520 42763 90306693
Swelling 251.32 9.85 575 278416 418483 89930973
Gastrointestinal disorder 247.29 9.85 255 278736 256432 90093024
Polycystic ovaries 246.35 9.85 175 278816 5479 90343977
Injection site pain 244.14 9.85 1121 277870 172578 90176878
Sleep disorder due to general medical condition, insomnia type 242.90 9.85 50 278941 128644 90220812
Blood cholesterol increased 240.02 9.85 174 278817 207838 90141618
Breast cancer stage III 239.38 9.85 4 278987 84443 90265013
Mobility decreased 238.26 9.85 252 278739 250482 90098974
Rash erythematous 238.07 9.85 581 278410 64523 90284933
Lip dry 233.35 9.85 21 278970 100934 90248522
Eczema 229.78 9.85 505 278486 52365 90297091
Treatment failure 229.51 9.85 363 278628 303565 90045891
Seasonal allergy 226.28 9.85 315 278676 22668 90326788
Gastrooesophageal reflux disease 225.31 9.85 1062 277929 165275 90184181
Eosinophilia 224.59 9.85 352 278639 28181 90321275
Off label use 217.86 9.85 2258 276733 1099994 89249462
Intentional product use issue 213.99 9.85 211 278780 216681 90132775
Eye pruritus 210.54 9.85 345 278646 28682 90320774
Secretion discharge 210.02 9.85 252 278739 15644 90333812
Neutropenia 209.27 9.85 230 278761 224674 90124782
Musculoskeletal stiffness 208.34 9.85 371 278620 296161 90053295
Loss of personal independence in daily activities 206.74 9.85 899 278092 135206 90214250
Sensitisation 204.83 9.85 139 278852 4036 90345420
Sneezing 204.59 9.85 346 278645 29523 90319933
Total lung capacity increased 204.11 9.85 149 278842 4872 90344584
Acute kidney injury 199.87 9.85 430 278561 319957 90029499
Oropharyngeal pain 199.38 9.85 792 278199 114395 90235061
Blood test abnormal 194.20 9.85 279 278712 20673 90328783
Suicidal ideation 192.64 9.85 582 278409 73273 90276183
Live birth 192.53 9.85 13 278978 79094 90270362
Malignant neoplasm progression 188.74 9.85 48 278943 106822 90242634
Asthma-chronic obstructive pulmonary disease overlap syndrome 184.83 9.85 139 278852 4760 90344696
Hypercholesterolaemia 184.68 9.85 42 278949 100850 90248606
Sinusitis 183.68 9.85 1736 277255 341352 90008104
Inflammation 179.33 9.85 171 278820 178421 90171035
Ear pruritus 178.24 9.85 156 278835 6647 90342809
Liver disorder 178.11 9.85 75 278916 121194 90228262
Bronchiectasis 175.09 9.85 275 278716 22055 90327401
Ill-defined disorder 173.18 9.85 188 278803 184703 90164753
Headache 172.40 9.85 3663 275328 859083 89490373
Reversible airways obstruction 169.14 9.85 94 278897 1889 90347567
Rales 166.49 9.85 224 278767 15603 90333853
Throat clearing 165.14 9.85 118 278873 3729 90345727
Wound infection 164.15 9.85 61 278930 106341 90243115
Febrile neutropenia 163.25 9.85 148 278843 158201 90191255
Red blood cell sedimentation rate increased 162.39 9.85 29 278962 82566 90266890
Injury 161.29 9.85 223 278768 197126 90152330
Discomfort 160.64 9.85 381 278610 273954 90075502
Peripheral venous disease 159.60 9.85 32 278959 83889 90265567
Grip strength decreased 158.89 9.85 44 278947 92532 90256924
Ejection fraction 156.73 9.85 104 278887 2907 90346549
Rhinitis 156.57 9.85 201 278790 13371 90336085
Adjustment disorder with depressed mood 151.99 9.85 5 278986 56748 90292708
Night sweats 148.11 9.85 108 278883 128658 90220798
Infective pulmonary exacerbation of cystic fibrosis 147.50 9.85 170 278821 10109 90339347
Bronchospasm 147.30 9.85 244 278747 20465 90328991
Vital capacity decreased 146.39 9.85 83 278908 1736 90347720
Pancytopenia 146.13 9.85 95 278896 120168 90229288
COVID-19 143.63 9.85 951 278040 167892 90181564
Disease progression 142.54 9.85 163 278828 156452 90193004
Inappropriate schedule of product administration 142.07 9.85 868 278123 149065 90200391
Therapeutic product effect incomplete 141.45 9.85 1052 277939 192844 90156612
Bone erosion 140.84 9.85 5 278986 53016 90296440
Exposure via skin contact 140.27 9.85 169 278822 10536 90338920
Myelosuppression 139.14 9.85 6 278985 53585 90295871
Prescribed underdose 137.76 9.85 31 278960 74988 90274468
Gait inability 137.04 9.85 149 278842 146307 90203149
Aggression 133.61 9.85 270 278721 26398 90323058
Dysphonia 133.61 9.85 463 278528 62621 90286835
Bronchial secretion retention 132.91 9.85 101 278890 3514 90345942
Pruritus 131.09 9.85 2368 276623 539157 89810299
Heart rate increased 130.94 9.85 690 278301 112212 90237244
Abnormal behaviour 130.33 9.85 243 278748 22385 90327071
Chest X-ray abnormal 130.07 9.85 115 278876 4967 90344489
Anaemia 129.86 9.85 601 278390 352201 89997255
Sensitivity to weather change 128.87 9.85 148 278843 8766 90340690
Lacrimation increased 128.51 9.85 268 278723 26794 90322662
Multiple allergies 125.00 9.85 191 278800 14955 90334501
Sciatica 124.66 9.85 79 278912 101303 90248153
Epilepsy 123.69 9.85 49 278942 82157 90267299
Type 2 diabetes mellitus 123.19 9.85 277 278714 202967 90146489
X-ray abnormal 121.65 9.85 4 278987 45420 90304036
Hyperhidrosis 121.57 9.85 777 278214 135528 90213928
Perfume sensitivity 121.57 9.85 60 278931 935 90348521
Musculoskeletal pain 121.33 9.85 213 278778 171038 90178418
Delirium 118.11 9.85 89 278902 104270 90245186
Drug interaction 117.80 9.85 445 278546 276008 90073448
Lower limb fracture 116.39 9.85 58 278933 84955 90264501
Drug abuse 116.07 9.85 54 278937 82293 90267163
Hip arthroplasty 113.72 9.85 46 278945 76162 90273294
Sarcoidosis 113.71 9.85 152 278839 10521 90338935
Completed suicide 113.48 9.85 169 278822 144889 90204567
Cardiac murmur 113.17 9.85 202 278789 17992 90331464
Death 112.53 9.85 883 278108 455668 89893788
Respiratory rate increased 111.76 9.85 187 278804 15814 90333642
Pulmonary mass 110.77 9.85 262 278729 28510 90320946
Onychomadesis 110.64 9.85 8 278983 45990 90303466
Angioedema 110.55 9.85 444 278547 64432 90285024
Peak expiratory flow rate decreased 110.30 9.85 49 278942 593 90348863
Autoimmune disorder 110.23 9.85 49 278942 76695 90272761
Restrictive pulmonary disease 109.64 9.85 76 278915 2286 90347170
Sputum increased 109.56 9.85 83 278908 2874 90346582
Sinus disorder 108.87 9.85 291 278700 34156 90315300
Respiration abnormal 108.09 9.85 128 278863 7835 90341621
Chronic spontaneous urticaria 107.36 9.85 68 278923 1752 90347704
Lung hyperinflation 107.30 9.85 62 278929 1346 90348110
Respiratory tract congestion 107.05 9.85 251 278740 27159 90322297
Foetal death 106.43 9.85 212 278779 20511 90328945
Mood altered 106.19 9.85 190 278801 16954 90332502
Decreased appetite 105.97 9.85 701 278290 375839 89973617
Product dose omission in error 105.60 9.85 210 278781 20293 90329163
Erythema 105.18 9.85 1124 277867 228122 90121334
Fluid retention 101.19 9.85 537 278454 87554 90261902
Nasal obstruction 100.52 9.85 75 278916 2537 90346919
Sleep terror 100.50 9.85 94 278897 4370 90345086
Blepharospasm 99.64 9.85 24 278967 55421 90294035
Feeling abnormal 99.42 9.85 866 278125 166369 90183087
Hepatic enzyme increased 99.29 9.85 676 278315 360060 89989396
Osteoarthritis 98.46 9.85 293 278698 195437 90154019
Rhonchi 98.18 9.85 78 278913 2900 90346556
Blood lactic acid increased 98.13 9.85 128 278863 8650 90340806
Anxiety 97.40 9.85 1415 277576 308357 90041099
Multiple organ dysfunction syndrome 96.02 9.85 45 278946 68291 90281165
Coeliac disease 95.84 9.85 329 278662 44281 90305175
Emphysema 94.33 9.85 149 278842 12006 90337450
Dust allergy 92.48 9.85 47 278944 782 90348674
Carpal tunnel syndrome 92.24 9.85 218 278773 23710 90325746
Status asthmaticus 91.73 9.85 48 278943 851 90348605
Mucosal inflammation 90.63 9.85 32 278959 57593 90291863
Blood pressure increased 90.00 9.85 966 278025 196251 90153205
Tic 89.90 9.85 62 278929 1849 90347607
Nasal discharge discolouration 88.27 9.85 72 278919 2781 90346675
Depressed mood 87.40 9.85 346 278645 49876 90299580
Toxic epidermal necrolysis 86.63 9.85 3 278988 32525 90316931
Abnormal dreams 85.99 9.85 137 278854 11120 90338336
Viral infection 85.99 9.85 302 278689 41112 90308344
Hepatic cirrhosis 85.32 9.85 44 278947 63209 90286247
Sputum culture positive 85.16 9.85 64 278927 2189 90347267
Malaise 84.39 9.85 2381 276610 583605 89765851
Diarrhoea 84.24 9.85 2225 276766 936965 89412491
C-reactive protein 83.16 9.85 3 278988 31364 90318092
Knee arthroplasty 83.05 9.85 80 278911 83102 90266354
Burning sensation 82.83 9.85 401 278590 63051 90286405
Incorrect dose administered 82.50 9.85 469 278522 78461 90270995
Lupus-like syndrome 82.36 9.85 24 278967 48822 90300634
Bronchopulmonary aspergillosis allergic 82.29 9.85 78 278913 3688 90345768
Stress 82.04 9.85 479 278512 80916 90268540
Nail disorder 81.30 9.85 40 278951 59027 90290429
Allergy to animal 80.98 9.85 55 278936 1599 90347857
Drug hypersensitivity 80.76 9.85 1932 277059 461677 89887779
Frequent bowel movements 80.75 9.85 37 278954 56898 90292558
Poor quality sleep 80.46 9.85 211 278780 24482 90324974
Throat tightness 80.32 9.85 236 278755 29248 90320208
Peripheral swelling 79.99 9.85 849 278142 412257 89937199
Rheumatoid arthritis 79.96 9.85 722 278269 361892 89987564
Septic shock 79.40 9.85 85 278906 84075 90265381
Crying 79.38 9.85 215 278776 25430 90324026
Neuropsychiatric symptoms 78.95 9.85 40 278951 661 90348795
Intentional overdose 78.68 9.85 104 278887 93730 90255726
Blood pressure systolic increased 78.53 9.85 372 278619 57973 90291483
Foot deformity 78.24 9.85 43 278948 59608 90289848
Aphonia 78.20 9.85 138 278853 12181 90337275
Fibromyalgia 77.24 9.85 349 278642 205920 90143536
Forced vital capacity decreased 77.04 9.85 47 278944 1131 90348325
Drug-induced liver injury 76.86 9.85 99 278892 90219 90259237
Therapy non-responder 76.69 9.85 194 278797 136510 90212946
Respiratory syncytial virus test positive 76.42 9.85 45 278946 1013 90348443
Haemoptysis 76.23 9.85 251 278740 33069 90316387
Total lung capacity decreased 76.14 9.85 75 278916 3720 90345736
Hypotension 76.13 9.85 638 278353 324759 90024697
Respiratory symptom 76.11 9.85 79 278912 4173 90345283
Drug tolerance decreased 76.11 9.85 6 278985 32124 90317332
Anger 76.11 9.85 145 278846 13575 90335881
Ejection fraction abnormal 75.26 9.85 62 278929 2429 90347027
Bronchial obstruction 75.26 9.85 53 278938 1636 90347820
Pulmonary fibrosis 74.96 9.85 135 278856 107368 90242088
Pulmonary function test decreased 72.48 9.85 79 278912 4415 90345041
Human rhinovirus test positive 72.12 9.85 41 278950 862 90348594
Exostosis 71.60 9.85 37 278954 53097 90296359
Taste disorder 71.57 9.85 51 278940 61495 90287961
Hyponatraemia 70.74 9.85 195 278796 133343 90216113
Injection site erythema 70.39 9.85 532 278459 97970 90251486
Sinusitis fungal 70.29 9.85 54 278937 1910 90347546
Joint stiffness 70.15 9.85 82 278909 77960 90271496
Throat irritation 69.61 9.85 316 278675 48379 90301077
Injection site scab 68.71 9.85 36 278955 640 90348816
Mast cell activation syndrome 68.67 9.85 49 278942 1545 90347911
Bronchial wall thickening 68.51 9.85 55 278936 2076 90347380
Urticaria chronic 68.40 9.85 38 278953 763 90348693
Road traffic accident 67.39 9.85 144 278847 107482 90241974
Scratch 67.17 9.85 114 278877 9752 90339704
Product use in unapproved indication 66.24 9.85 1426 277565 334810 90014646
Hypokalaemia 66.12 9.85 196 278795 130920 90218536
Nasal turbinate hypertrophy 66.07 9.85 39 278952 882 90348574
Back pain 66.00 9.85 1356 277635 315819 90033637
Dyspepsia 65.69 9.85 350 278641 197810 90151646
Cardiac disorder 65.51 9.85 347 278644 56525 90292931
Bronchial disorder 65.29 9.85 47 278944 1503 90347953
Poor quality device used 64.98 9.85 55 278936 2238 90347218
Colitis ulcerative 64.91 9.85 54 278937 60212 90289244
Bronchial neoplasm 64.87 9.85 32 278959 498 90348958
Coma 64.55 9.85 77 278914 72555 90276901
Depressed level of consciousness 63.79 9.85 78 278913 72706 90276750
Asthma exercise induced 63.57 9.85 31 278960 470 90348986
Nephrectomy 63.42 9.85 51 278940 1930 90347526
Bradycardia 63.34 9.85 100 278891 83747 90265709
Sinus congestion 62.21 9.85 206 278785 27218 90322238
Muscular weakness 62.05 9.85 377 278614 206289 90143167
Red blood cell sedimentation rate abnormal 61.88 9.85 3 278988 24201 90325255
Leukopenia 61.20 9.85 137 278854 100573 90248883
Hypoaesthesia 61.08 9.85 645 278346 313565 90035891
Oxygen saturation decreased 60.97 9.85 551 278440 106932 90242524
Renal impairment 60.38 9.85 148 278843 105273 90244183
Hyper IgE syndrome 60.36 9.85 30 278961 475 90348981
Onychomycosis 60.08 9.85 20 278971 37356 90312100
Bone marrow failure 59.79 9.85 13 278978 32208 90317248
Prolonged expiration 59.65 9.85 41 278950 1216 90348240
Pregnancy 59.28 9.85 62 278929 61985 90287471
Metabolic acidosis 58.60 9.85 51 278940 55625 90293831
Vocal cord dysfunction 58.58 9.85 36 278955 878 90348578
Bronchial haemorrhage 58.57 9.85 32 278959 621 90348835
Cystic fibrosis 57.93 9.85 66 278925 3875 90345581
Eosinophil count abnormal 57.79 9.85 35 278956 831 90348625
Accidental exposure to product 57.65 9.85 271 278720 42095 90307361
Factor V Leiden mutation 57.52 9.85 25 278966 286 90349170
Swelling face 56.79 9.85 437 278554 80915 90268541
Pharyngeal swelling 56.28 9.85 106 278885 9838 90339618
Ascites 56.25 9.85 39 278952 47701 90301755
Skin plaque 56.05 9.85 106 278885 9869 90339587
Body tinea 55.76 9.85 49 278942 2099 90347357
Eye swelling 55.67 9.85 208 278783 29178 90320278
Therapeutic response shortened 55.64 9.85 176 278815 22703 90326753
Major depression 55.59 9.85 106 278885 9929 90339527
Obesity 55.18 9.85 155 278836 105352 90244104
Vasculitis 54.67 9.85 174 278817 22519 90326937
Quality of life decreased 54.42 9.85 116 278875 11773 90337683
Affective disorder 54.32 9.85 91 278900 7702 90341754
Salpingo-oophorectomy unilateral 54.20 9.85 35 278956 933 90348523
Finger deformity 53.95 9.85 17 278974 32880 90316576
Walking aid user 53.67 9.85 21 278970 35485 90313971
Dry mouth 53.57 9.85 339 278652 183720 90165736
Viral test positive 53.53 9.85 30 278961 613 90348843
Frustration tolerance decreased 53.44 9.85 91 278900 7805 90341651
Myalgia 53.42 9.85 796 278195 174329 90175127
Humidity intolerance 53.33 9.85 26 278965 394 90349062
Eosinophilic pneumonia 52.32 9.85 53 278938 2720 90346736
Colitis 52.28 9.85 84 278907 69858 90279598
Metastases to bone 52.25 9.85 8 278983 25497 90323959
Irritability 52.15 9.85 233 278758 35429 90314027
Lung opacity 51.84 9.85 78 278913 6024 90343432
Self-injurious ideation 51.13 9.85 56 278935 3147 90346309
Mood swings 51.03 9.85 160 278831 20542 90328914
Hypoventilation 49.77 9.85 71 278920 5225 90344231
Increased bronchial secretion 49.75 9.85 46 278945 2107 90347349
Dysphemia 49.57 9.85 54 278937 3016 90346440
Neoplasm progression 48.98 9.85 39 278952 44447 90305009
Aspirin-exacerbated respiratory disease 48.93 9.85 29 278962 661 90348795
Smoke sensitivity 48.75 9.85 26 278965 480 90348976
Hyperkalaemia 48.57 9.85 78 278913 64886 90284570
Anosmia 48.49 9.85 99 278892 9749 90339707
Neurotoxicity 48.18 9.85 5 278986 21462 90327994
Liver function test increased 47.91 9.85 120 278871 84735 90264721
Sopor 47.69 9.85 9 278982 24635 90324821
Idiopathic intracranial hypertension 47.68 9.85 57 278934 3524 90345932
Medication error 47.57 9.85 120 278871 84532 90264924
Alanine aminotransferase increased 47.48 9.85 195 278796 118143 90231313
Mastocytosis 47.31 9.85 32 278959 924 90348532
Metastases to liver 47.04 9.85 15 278976 28792 90320664
Platelet count decreased 47.03 9.85 239 278752 136730 90212726
Injection site pruritus 46.81 9.85 305 278686 53529 90295927
Infusion site erythema 46.79 9.85 119 278872 13551 90335905
Platelet count increased 46.70 9.85 156 278835 20703 90328753
Infusion site swelling 46.50 9.85 108 278883 11612 90337844
Abdominal pain upper 46.46 9.85 732 278259 331942 90017514
Glucose tolerance impaired 46.29 9.85 86 278905 7899 90341557
Haemoglobin decreased 46.25 9.85 300 278691 161656 90187800
Pneumococcal infection 46.25 9.85 35 278956 1210 90348246
Oedema 46.24 9.85 870 278121 199425 90150031
Oral allergy syndrome 46.17 9.85 16 278975 93 90349363
Lung neoplasm malignant 46.14 9.85 172 278819 24101 90325355
Dry skin 45.69 9.85 443 278548 87630 90261826
Muscle spasticity 45.55 9.85 26 278965 35296 90314160
Injection site swelling 45.48 9.85 328 278663 59511 90289945
Rectal haemorrhage 45.19 9.85 119 278872 82625 90266831
Cholecystitis chronic 45.13 9.85 96 278895 9730 90339726
Cytomegalovirus infection 44.97 9.85 13 278978 26589 90322867
Inhibitory drug interaction 44.86 9.85 52 278939 3111 90346345
Chest pain 44.83 9.85 1295 277696 318350 90031106
Hereditary angioedema 44.76 9.85 93 278898 9272 90340184
Renal disorder 44.29 9.85 232 278759 37627 90311829
Spirometry abnormal 44.09 9.85 20 278971 255 90349201
Respiratory tract inflammation 43.81 9.85 26 278965 594 90348862
Eye irritation 43.81 9.85 214 278777 33764 90315692
Generalised anxiety disorder 43.80 9.85 48 278943 2699 90346757
Mite allergy 43.69 9.85 29 278962 811 90348645
Porphyria acute 43.60 9.85 3 278988 17972 90331484
Injection site bruising 43.45 9.85 293 278698 52014 90297442
Palmar-plantar erythrodysaesthesia syndrome 43.32 9.85 16 278975 28007 90321449
Infusion site pruritus 43.22 9.85 76 278915 6689 90342767
Atopy 42.95 9.85 20 278971 272 90349184
Endometrial ablation 42.88 9.85 31 278960 998 90348458
Incorrect route of product administration 42.55 9.85 56 278935 50570 90298886
Pustular psoriasis 42.49 9.85 4 278987 18552 90330904
Heart sounds 42.14 9.85 32 278959 1112 90348344
Agranulocytosis 42.03 9.85 28 278963 34974 90314482
Adverse event 41.97 9.85 202 278789 117216 90232240
Obsessive-compulsive disorder 41.77 9.85 60 278931 4444 90345012
Condition aggravated 41.37 9.85 1459 277532 594086 89755370
Sepsis 41.36 9.85 354 278637 179460 90169996
Surgery 41.30 9.85 258 278733 44629 90304827
Blood potassium decreased 41.25 9.85 270 278721 47457 90301999
Hypomania 40.95 9.85 87 278904 8810 90340646
Attention deficit hyperactivity disorder 40.66 9.85 57 278934 4127 90345329
Appetite disorder 40.53 9.85 88 278903 9045 90340411
Infection susceptibility increased 40.43 9.85 55 278936 3871 90345585
Injection site rash 40.03 9.85 164 278827 24009 90325447
Paranasal sinus discomfort 39.98 9.85 70 278921 6140 90343316
Blood immunoglobulin E decreased 39.86 9.85 17 278974 185 90349271
Aspartate aminotransferase increased 39.82 9.85 172 278819 102765 90246691
Hepatitis 39.19 9.85 101 278890 70638 90278818
FEV1/FVC ratio decreased 39.16 9.85 16 278975 155 90349301
Joint dislocation 38.83 9.85 48 278943 44534 90304922
Creatinine renal clearance decreased 38.55 9.85 6 278985 18893 90330563
Decreased immune responsiveness 38.49 9.85 84 278907 8664 90340792
Pneumonia haemophilus 38.44 9.85 34 278957 1469 90347987
Bronchitis chronic 38.00 9.85 59 278932 4684 90344772
White blood cell count decreased 37.98 9.85 330 278661 166779 90182677
Lip swelling 37.47 9.85 225 278766 38385 90311071
No adverse event 37.27 9.85 346 278645 67636 90281820
Product label confusion 37.13 9.85 12 278979 22838 90326618
Upper limb fracture 37.00 9.85 148 278843 21430 90328026
Psoriasis 36.97 9.85 650 278341 147104 90202352
Depression 36.85 9.85 1198 277793 299403 90050053
Back injury 36.75 9.85 54 278937 46568 90302888
Vision blurred 36.67 9.85 509 278482 109784 90239672
Pharyngitis streptococcal 36.64 9.85 104 278887 12638 90336818
Respiratory gas exchange disorder 36.57 9.85 20 278971 389 90349067
Injection site urticaria 36.23 9.85 130 278861 17881 90331575
Ear discomfort 36.18 9.85 90 278901 10110 90339346
Cardiac arrest 36.08 9.85 183 278808 104752 90244704
Ankle fracture 35.97 9.85 141 278850 20229 90329227
Ulcer haemorrhage 35.95 9.85 18 278973 26303 90323153
Cardio-respiratory arrest 35.87 9.85 89 278902 63051 90286405
Conjunctivitis allergic 35.81 9.85 31 278960 1301 90348155
Biliary dyskinesia 35.64 9.85 42 278949 2557 90346899
Cytokine release syndrome 35.49 9.85 21 278970 27952 90321504
Bronchial hyperreactivity 35.39 9.85 37 278954 1971 90347485
Nervousness 35.34 9.85 202 278789 33854 90315602
Acute myeloid leukaemia 35.05 9.85 10 278981 20630 90328826
Hepatocellular injury 34.99 9.85 23 278968 28935 90320521
Jaundice cholestatic 34.98 9.85 88 278903 9955 90339501
Lipohypertrophy 34.82 9.85 24 278967 715 90348741
Snoring 34.59 9.85 59 278932 5067 90344389
Neutrophil count decreased 34.58 9.85 109 278882 71423 90278033
Product use issue 33.95 9.85 765 278226 329154 90020302
Rash maculo-papular 33.67 9.85 46 278945 40887 90308569
Tongue biting 33.54 9.85 37 278954 2096 90347360
Hypomagnesaemia 33.50 9.85 36 278955 35552 90313904
Muscle tension dysphonia 33.50 9.85 17 278974 282 90349174
Arthralgia 33.46 9.85 2009 276982 776513 89572943
Ligament sprain 33.41 9.85 110 278881 14489 90334967
CFTR gene mutation 33.38 9.85 16 278975 233 90349223
Embolism venous 33.24 9.85 48 278943 3572 90345884
Decreased activity 33.06 9.85 76 278915 8116 90341340
Thinking abnormal 33.00 9.85 95 278896 11637 90337819
Paranoia 32.96 9.85 101 278890 12807 90336649
Macular degeneration 32.94 9.85 41 278950 37929 90311527
Chronic sinusitis 32.93 9.85 153 278838 23649 90325807
Maternal exposure timing unspecified 32.84 9.85 14 278977 22469 90326987
Cholelithiasis 32.80 9.85 275 278716 52231 90297225
Pharyngeal oedema 32.63 9.85 105 278886 13666 90335790
Respiratory syncytial virus infection 32.57 9.85 88 278903 10392 90339064
Hypothyroidism 32.53 9.85 277 278714 52850 90296606
Orthostatic hypotension 32.43 9.85 49 278942 41778 90307678
Lung diffusion test decreased 32.29 9.85 24 278967 807 90348649
Neutropenic sepsis 32.28 9.85 8 278983 18122 90331334
Vaccination site pain 31.89 9.85 18 278973 373 90349083
Insomnia 31.82 9.85 1292 277699 332182 90017274
Occupational asthma 31.69 9.85 14 278977 167 90349289
Psychotic disorder 31.60 9.85 184 278807 31046 90318410
Oropharyngeal discomfort 31.48 9.85 72 278919 7663 90341793
Symptom recurrence 31.37 9.85 49 278942 3910 90345546
Drug level increased 30.99 9.85 24 278967 27738 90321718
Rhabdomyolysis 30.91 9.85 70 278921 51186 90298270
Tremor 30.88 9.85 652 278339 152521 90196935
Drug resistance 30.72 9.85 29 278962 30420 90319036
Cholestasis 30.66 9.85 40 278951 36259 90313197
Hypocalcaemia 30.62 9.85 52 278939 42316 90307140
Sinus polyp 30.58 9.85 18 278973 405 90349051
Acute respiratory distress syndrome 30.52 9.85 26 278965 28660 90320796
Feeling of despair 30.18 9.85 43 278948 3161 90346295
Choking sensation 30.14 9.85 48 278943 3894 90345562
Osteonecrosis of jaw 30.13 9.85 46 278945 39057 90310399
Foetal exposure during pregnancy 29.92 9.85 54 278937 42921 90306535
Dry eye 29.85 9.85 291 278700 57640 90291816
Sedation 29.69 9.85 65 278926 48106 90301350
Skin lesion 29.67 9.85 207 278784 37158 90312298
Skin swelling 29.66 9.85 64 278927 6550 90342906
Pneumothorax spontaneous 29.56 9.85 24 278967 921 90348535
Eosinophilic oesophagitis 29.35 9.85 23 278968 838 90348618
Disseminated intravascular coagulation 29.02 9.85 15 278976 21523 90327933
Normal newborn 28.99 9.85 18 278973 23344 90326112
Metastases to central nervous system 28.88 9.85 9 278982 17533 90331923
Memory impairment 28.87 9.85 430 278561 196814 90152642
Neurosensory hypoacusis 28.66 9.85 14 278977 213 90349243
Drug reaction with eosinophilia and systemic symptoms 28.64 9.85 55 278936 42703 90306753
Speech disorder 28.61 9.85 239 278752 45346 90304110
Transplant rejection 28.56 9.85 3 278988 12755 90336701
Bipolar disorder 28.48 9.85 76 278915 8909 90340547
Circulatory collapse 28.48 9.85 21 278970 24883 90324573
Haematochezia 28.35 9.85 117 278874 70796 90278660
Post-traumatic stress disorder 28.28 9.85 64 278927 6764 90342692
Dyspnoea at rest 28.28 9.85 52 278939 4739 90344717
Palpitations 28.21 9.85 584 278407 136144 90213312
Neuroleptic malignant syndrome 28.19 9.85 6 278985 15090 90334366
Hypertransaminasaemia 28.14 9.85 7 278984 15818 90333638
Hysterectomy 28.07 9.85 89 278902 11495 90337961
Emotional distress 27.88 9.85 201 278790 36461 90312995
Temperature intolerance 27.85 9.85 91 278900 11939 90337517
Tympanosclerosis 27.79 9.85 10 278981 66 90349390
Infusion site bruising 27.78 9.85 49 278942 4323 90345133
Blood calcium increased 27.73 9.85 91 278900 11967 90337489
Upper airway obstruction 27.71 9.85 24 278967 1008 90348448
Somnambulism 27.63 9.85 60 278931 6168 90343288
Premature delivery 27.62 9.85 48 278943 38714 90310742
Hepatic failure 27.59 9.85 50 278941 39678 90309778
Fungal infection 27.48 9.85 225 278766 42436 90307020
Anuria 27.45 9.85 6 278985 14812 90334644
Hiatus hernia 27.35 9.85 152 278839 25209 90324247
Cardiac failure 27.26 9.85 211 278780 109285 90240171
Inappropriate antidiuretic hormone secretion 27.16 9.85 13 278978 19492 90329964
Amniotic fluid index increased 27.15 9.85 11 278980 104 90349352
Separation anxiety disorder 27.03 9.85 8 278983 25 90349431
Cognitive disorder 26.83 9.85 116 278875 69291 90280165
Increased upper airway secretion 26.80 9.85 45 278946 3816 90345640
Influenza like illness 26.78 9.85 372 278619 80239 90269217
Infusion site pain 26.66 9.85 126 278865 19612 90329844
Increased viscosity of bronchial secretion 26.64 9.85 16 278975 374 90349082
Renal failure 26.63 9.85 266 278725 130741 90218715
Pre-existing condition improved 26.52 9.85 75 278916 9094 90340362
Obstruction 26.29 9.85 45 278946 3876 90345580
Exposure to allergen 26.24 9.85 18 278973 532 90348924
Blood creatine phosphokinase increased 26.24 9.85 40 278951 33983 90315473
Decreased interest 26.22 9.85 48 278943 4359 90345097
Adrenal suppression 26.16 9.85 23 278968 986 90348470
Gamma-glutamyltransferase increased 26.14 9.85 48 278943 37904 90311552
Mononeuropathy multiplex 26.12 9.85 16 278975 388 90349068
Forced expiratory volume abnormal 26.10 9.85 11 278980 116 90349340
Serotonin syndrome 26.03 9.85 48 278943 37839 90311617
Laryngeal stenosis 26.01 9.85 26 278965 1313 90348143
Encephalopathy 25.97 9.85 66 278925 46378 90303078
Nephropathy toxic 25.95 9.85 4 278987 12684 90336772
Hypercapnia 25.91 9.85 61 278930 6616 90342840
Flushing 25.72 9.85 399 278592 88092 90261364
Retching 25.66 9.85 122 278869 19037 90330419
Dehydration 25.42 9.85 433 278558 194014 90155442
Spinal operation 25.31 9.85 79 278912 10117 90339339
Intentional product misuse 25.28 9.85 402 278589 89202 90260254
Interstitial lung disease 25.27 9.85 135 278856 76270 90273186
Ocular hyperaemia 24.96 9.85 184 278807 33614 90315842
Product quality issue 24.73 9.85 362 278629 78963 90270493
Pulmonary pain 24.69 9.85 51 278940 5063 90344393
Hallucination 24.66 9.85 311 278680 65648 90283808
Nocturnal fear 24.58 9.85 6 278985 6 90349450
Acute hepatic failure 24.56 9.85 20 278971 22541 90326915
Lymphocyte count decreased 24.44 9.85 44 278947 35006 90314450
Terminal insomnia 24.36 9.85 24 278967 1191 90348265
Gastrointestinal haemorrhage 24.34 9.85 170 278821 90078 90259378
Gangrene 24.29 9.85 5 278986 12871 90336585
Swollen tongue 24.24 9.85 232 278759 45724 90303732
Sinus polyp degeneration 24.20 9.85 9 278982 66 90349390
Skin necrosis 24.04 9.85 11 278980 16930 90332526
Bacteraemia 23.99 9.85 20 278971 22280 90327176
Dyssomnia 23.92 9.85 8 278983 41 90349415
Expiratory reserve volume decreased 23.61 9.85 8 278983 43 90349413
Haemophagocytic lymphohistiocytosis 23.60 9.85 9 278982 15450 90334006
Depressive symptom 23.54 9.85 51 278940 5234 90344222
Hepatic function abnormal 23.47 9.85 69 278922 46219 90303237
Cone-rod dystrophy 23.25 9.85 6 278985 9 90349447
Skin discomfort 23.03 9.85 29 278962 1892 90347564
Skin ulcer 23.03 9.85 78 278913 49997 90299459
Hypercalcaemia 22.97 9.85 44 278947 34196 90315260
Intentional dose omission 22.92 9.85 112 278879 17671 90331785
Torsade de pointes 22.91 9.85 9 278982 15173 90334283
Thrombocytopenia 22.89 9.85 479 278512 208246 90141210
Exposure to fungus 22.87 9.85 12 278979 214 90349242
Ligament pain 22.82 9.85 12 278979 215 90349241
Vaginal discharge 22.80 9.85 16 278975 19448 90330008
Panniculitis 22.78 9.85 8 278983 14450 90335006
Airway remodelling 22.70 9.85 9 278982 80 90349376
Nocturnal dyspnoea 22.68 9.85 25 278966 1415 90348041
Pulmonary thrombosis 22.65 9.85 74 278917 9708 90339748
Mechanical urticaria 22.48 9.85 17 278974 587 90348869
Progressive multifocal leukoencephalopathy 22.47 9.85 10 278981 15645 90333811
Bronchospasm paradoxical 22.44 9.85 10 278981 122 90349334
Acute sinusitis 22.37 9.85 44 278947 4217 90345239
Nasal inflammation 22.32 9.85 18 278973 684 90348772
Respiratory disorder 22.30 9.85 301 278690 64515 90284941
Lower respiratory tract congestion 21.83 9.85 38 278953 3318 90346138
Ear swelling 21.73 9.85 28 278963 1869 90347587
Posterior reversible encephalopathy syndrome 21.70 9.85 22 278969 22317 90327139
Oral herpes 21.70 9.85 177 278814 33347 90316109
Infection 21.59 9.85 903 278088 361191 89988265
Eye discharge 21.45 9.85 65 278926 8193 90341263
Tenosynovitis 21.39 9.85 9 278982 14558 90334898
Laryngitis fungal 21.38 9.85 11 278980 188 90349268
Accident 21.22 9.85 58 278933 6896 90342560
Mycotic allergy 21.10 9.85 21 278970 1055 90348401
Hospitalisation 21.07 9.85 530 278461 127570 90221886
Rhinitis perennial 21.07 9.85 7 278984 35 90349421
Sputum culture 21.01 9.85 13 278978 321 90349135
Sinus operation 20.95 9.85 35 278956 2956 90346500
Premature baby 20.81 9.85 28 278963 25049 90324407
Electrocardiogram QT prolonged 20.78 9.85 134 278857 72322 90277134
Body temperature decreased 20.74 9.85 135 278856 23681 90325775
Schizophrenia 20.73 9.85 96 278895 14818 90334638
Diverticulum 20.71 9.85 83 278908 12030 90337426
Radiculopathy 20.65 9.85 16 278975 18489 90330967
Pulmonary congestion 20.64 9.85 116 278875 19317 90330139
Injection site discomfort 20.63 9.85 52 278939 5888 90343568
Blood parathyroid hormone decreased 20.60 9.85 6 278985 12210 90337246
Mental disorder 20.58 9.85 170 278821 32148 90317308
Ulcer 20.57 9.85 44 278947 32838 90316618
Wrist fracture 20.57 9.85 99 278892 15525 90333931
Pulmonary embolism 20.57 9.85 538 278453 130282 90219174
Hepatic cytolysis 20.51 9.85 40 278951 30876 90318580
Psychomotor hyperactivity 20.48 9.85 86 278905 12727 90336729
Alice in wonderland syndrome 20.45 9.85 7 278984 39 90349417
Metastases to lung 20.29 9.85 12 278979 15979 90333477
White coat hypertension 20.09 9.85 20 278971 1005 90348451
Asthenia 20.03 9.85 1394 277597 532357 89817099
Pathergy reaction 20.00 9.85 8 278983 73 90349383
Forced expiratory volume increased 20.00 9.85 8 278983 73 90349383
Oral pruritus 19.96 9.85 34 278957 2917 90346539
Injection site movement impairment 19.76 9.85 6 278985 21 90349435
Breast cancer metastatic 19.71 9.85 11 278980 15121 90334335
Tuberculosis 19.68 9.85 7 278984 12542 90336914
Social anxiety disorder 19.64 9.85 16 278975 617 90348839
SARS-CoV-2 test positive 19.62 9.85 77 278914 11051 90338405
Sinus pain 19.59 9.85 48 278943 5341 90344115
Abdominal pain 19.55 9.85 1007 277984 394714 89954742
Hypoglobulinaemia 19.54 9.85 10 278981 169 90349287
Infusion site haemorrhage 19.46 9.85 48 278943 5363 90344093
Haemodynamic instability 19.37 9.85 6 278985 11733 90337723
Acute generalised exanthematous pustulosis 19.28 9.85 9 278982 13694 90335762
Middle ear effusion 19.27 9.85 32 278959 2689 90346767
PO2 decreased 19.16 9.85 24 278967 1557 90347899
Infusion site urticaria 19.16 9.85 25 278966 1690 90347766
Arthropod bite 19.13 9.85 65 278926 8702 90340754
Lactic acidosis 19.10 9.85 85 278906 50378 90299078
Mouth swelling 19.08 9.85 49 278942 5613 90343843
Altered state of consciousness 19.06 9.85 43 278948 31489 90317967
Therapeutic response unexpected 19.04 9.85 124 278867 21756 90327700
Myositis 18.96 9.85 28 278963 24100 90325356
Stress urinary incontinence 18.95 9.85 30 278961 2422 90347034
Otorrhoea 18.91 9.85 26 278965 1849 90347607
Cerebral infarction 18.89 9.85 33 278958 26563 90322893
Pulmonary toxicity 18.83 9.85 6 278985 11525 90337931
Hyperlipidaemia 18.81 9.85 128 278863 22788 90326668
Blood alkaline phosphatase increased 18.80 9.85 80 278911 47999 90301457
Foetal macrosomia 18.75 9.85 11 278980 246 90349210
Product container issue 18.70 9.85 28 278963 2153 90347303
Overweight 18.62 9.85 50 278941 5884 90343572
Product administration interrupted 18.55 9.85 82 278909 12410 90337046
Drug eruption 18.52 9.85 52 278939 35355 90314101
Candida infection 18.50 9.85 173 278818 33884 90315572
Functional residual capacity increased 18.45 9.85 8 278983 91 90349365
Accidental overdose 18.39 9.85 37 278954 28236 90321220
Diastolic dysfunction 18.37 9.85 57 278934 7276 90342180
Respiratory tract irritation 18.33 9.85 14 278977 491 90348965
Adverse drug reaction 18.27 9.85 251 278740 116450 90233006
Basal cell carcinoma 18.24 9.85 48 278943 33341 90316115
Blood pressure fluctuation 18.24 9.85 91 278900 52322 90297134
Visual impairment 18.20 9.85 292 278699 132073 90217383
Product substitution issue 18.15 9.85 106 278885 17902 90331554
Drug tolerance 18.15 9.85 17 278974 17899 90331557
Hypoglycaemia 18.14 9.85 133 278858 69715 90279741
Ischaemic stroke 18.14 9.85 25 278966 22141 90327315
Blood pressure abnormal 18.12 9.85 113 278878 19532 90329924
Panic attack 18.04 9.85 141 278850 26224 90323232
Haematotoxicity 18.00 9.85 8 278983 12527 90336929
Hemiplegia 18.00 9.85 14 278977 16146 90333310
Allergic sinusitis 17.94 9.85 27 278964 2086 90347370
Stevens-Johnson syndrome 17.81 9.85 40 278951 29336 90320120
Sinus headache 17.79 9.85 52 278939 6424 90343032
Oesophageal dilatation 17.75 9.85 14 278977 515 90348941
Cardiogenic shock 17.71 9.85 30 278961 24438 90325018
Skin burning sensation 17.59 9.85 112 278879 19499 90329957
Lymphopenia 17.55 9.85 27 278964 22854 90326602
Product taste abnormal 17.51 9.85 29 278962 2431 90347025
Pleural effusion 17.49 9.85 241 278750 111750 90237706
Allergy test positive 17.43 9.85 16 278975 726 90348730
Oropharyngitis fungal 17.39 9.85 7 278984 65 90349391
Proteinuria 17.38 9.85 28 278963 23263 90326193
Hyposmia 17.34 9.85 18 278973 951 90348505
Mucosal discolouration 17.32 9.85 15 278976 630 90348826
Obsessive-compulsive symptom 17.30 9.85 8 278983 107 90349349
Sinus bradycardia 17.27 9.85 16 278975 16936 90332520
Sedation complication 17.26 9.85 16 278975 16928 90332528
General symptom 17.25 9.85 12 278979 14656 90334800
Miosis 17.25 9.85 4 278987 9480 90339976
Hyperphagia 17.16 9.85 31 278960 2787 90346669
Pneumocystis jirovecii pneumonia 17.07 9.85 25 278966 21591 90327865
Forced expiratory volume 17.05 9.85 5 278986 15 90349441
Infusion site extravasation 17.04 9.85 70 278921 10258 90339198
Underdose 17.01 9.85 97 278894 53920 90295536
Cold urticaria 16.98 9.85 11 278980 295 90349161
Injection site hypoaesthesia 16.92 9.85 15 278976 650 90348806
Vasomotor rhinitis 16.91 9.85 10 278981 227 90349229
Urticaria pressure 16.85 9.85 7 278984 71 90349385
Overlap syndrome 16.80 9.85 3 278988 8545 90340911
Eye paraesthesia 16.79 9.85 9 278982 168 90349288
Educational problem 16.77 9.85 14 278977 559 90348897
Lactose intolerance 16.74 9.85 34 278957 3335 90346121
Diabetic ketoacidosis 16.69 9.85 31 278960 24376 90325080
Tubulointerstitial nephritis 16.63 9.85 33 278958 25310 90324146
Arthritis 16.62 9.85 390 278601 166925 90182531
Postural orthostatic tachycardia syndrome 16.47 9.85 27 278964 2245 90347211
Social avoidant behaviour 16.44 9.85 34 278957 3379 90346077
Oxygen consumption decreased 16.37 9.85 11 278980 314 90349142
Hypersomnia 16.35 9.85 118 278873 21413 90328043
Insurance issue 16.33 9.85 72 278919 10886 90338570
Respiratory tract infection viral 16.29 9.85 32 278959 3064 90346392
Poisoning deliberate 16.28 9.85 16 278975 16470 90332986
Tongue injury 16.27 9.85 14 278977 583 90348873
Product availability issue 16.24 9.85 55 278936 7349 90342107
Body temperature abnormal 16.22 9.85 29 278962 2586 90346870
Fear 16.21 9.85 97 278894 16525 90332931
Hypoalbuminaemia 16.20 9.85 15 278976 15882 90333574
Onychophagia 16.19 9.85 7 278984 79 90349377
Chills 16.15 9.85 526 278465 131455 90218001
Airway peak pressure increased 16.08 9.85 12 278979 406 90349050
Bacterial disease carrier 16.06 9.85 24 278967 1842 90347614
Blood lactate dehydrogenase increased 15.97 9.85 35 278956 25897 90323559
Stab wound 15.96 9.85 7 278984 82 90349374
Gallbladder disorder 15.89 9.85 110 278881 19693 90329763
Anaphylactic shock 15.89 9.85 158 278833 31459 90317997
Subarachnoid haemorrhage 15.88 9.85 19 278972 17885 90331571
Lipoma 15.88 9.85 31 278960 2955 90346501
Restless legs syndrome 15.84 9.85 121 278870 22349 90327107
Oppositional defiant disorder 15.68 9.85 6 278985 48 90349408
Cortisol decreased 15.68 9.85 23 278968 1736 90347720
Hyperventilation 15.67 9.85 51 278940 6677 90342779
Periorbital swelling 15.63 9.85 41 278950 4757 90344699
Stress cardiomyopathy 15.61 9.85 11 278980 13344 90336112
Aspiration 15.58 9.85 92 278899 15601 90333855
Neurologic neglect syndrome 15.56 9.85 4 278987 8843 90340613
Aplastic anaemia 15.42 9.85 11 278980 13258 90336198
Low birth weight baby 15.33 9.85 5 278986 9462 90339994
Left-to-right cardiac shunt 15.31 9.85 10 278981 272 90349184
Glossitis 15.28 9.85 34 278957 3553 90345903
Hepatic encephalopathy 15.25 9.85 12 278979 13760 90335696
Toxic encephalopathy 15.18 9.85 4 278987 8695 90340761
Ehlers-Danlos syndrome 14.98 9.85 11 278980 363 90349093
Gastroenteritis viral 14.92 9.85 151 278840 30204 90319252
Feeling guilty 14.91 9.85 14 278977 654 90348802
Spondylitis 14.90 9.85 13 278978 14165 90335291
Clostridium difficile colitis 14.89 9.85 38 278953 26668 90322788
Wrong technique in product usage process 14.85 9.85 306 278685 71265 90278191
Psychiatric symptom 14.85 9.85 52 278939 7066 90342390
Agoraphobia 14.83 9.85 13 278978 555 90348901
Melaena 14.80 9.85 56 278935 34741 90314715
Left ventricular dysfunction 14.76 9.85 14 278977 14655 90334801
Status epilepticus 14.74 9.85 22 278969 18852 90330604
Bronchial irritation 14.73 9.85 5 278986 27 90349429
Pneumonia viral 14.72 9.85 60 278931 8763 90340693
Coagulopathy 14.71 9.85 31 278960 23258 90326198
Disease recurrence 14.71 9.85 179 278812 37474 90311982
Female sterilisation 14.65 9.85 14 278977 669 90348787
Contusion 14.64 9.85 628 278363 250588 90098868
Sensation of foreign body 14.60 9.85 48 278943 6318 90343138
Blood calcium decreased 14.58 9.85 46 278945 30136 90319320
Immunisation reaction 14.57 9.85 15 278976 785 90348671
Renal tubular necrosis 14.52 9.85 14 278977 14541 90334915
Initial insomnia 14.50 9.85 62 278929 9248 90340208
Suicidal behaviour 14.49 9.85 29 278962 2815 90346641
PCO2 increased 14.45 9.85 19 278972 1294 90348162
Gluten sensitivity 14.44 9.85 15 278976 793 90348663
Hypothermia 14.39 9.85 16 278975 15559 90333897
Hyperbilirubinaemia 14.38 9.85 13 278978 13923 90335533
Platelet adhesiveness decreased 14.36 9.85 3 278988 0 90349456
Hyperarousal 14.36 9.85 3 278988 0 90349456
Pulmonary function challenge test abnormal 14.36 9.85 3 278988 0 90349456
Sleep study abnormal 14.36 9.85 3 278988 0 90349456
Glomus tumour 14.36 9.85 3 278988 0 90349456
Myoclonus 14.34 9.85 23 278968 19145 90330311
Mouth haemorrhage 14.33 9.85 58 278933 8443 90341013
Lower respiratory tract infection 14.32 9.85 628 278363 250031 90099425
Pneumonia aspiration 14.29 9.85 71 278920 40869 90308587
Device expulsion 14.22 9.85 71 278920 40815 90308641
Forced expiratory flow decreased 14.13 9.85 7 278984 110 90349346
Eosinophilic pneumonia acute 14.10 9.85 14 278977 701 90348755
Suffocation feeling 14.10 9.85 21 278970 1607 90347849
Infusion site reaction 14.10 9.85 23 278968 19016 90330440
Skin fissures 14.08 9.85 111 278880 20698 90328758
Breast cancer stage I 14.05 9.85 6 278985 9618 90339838
Uveitis 13.98 9.85 17 278974 15886 90333570
Cytopenia 13.96 9.85 20 278971 17429 90332027
Unresponsive to stimuli 13.96 9.85 65 278926 38056 90311400
Neutrophil toxic granulation present 13.95 9.85 8 278983 171 90349285
Lip pruritus 13.93 9.85 19 278972 1341 90348115
Myelodysplastic syndrome 13.90 9.85 27 278964 20876 90328580
Adverse reaction 13.85 9.85 46 278945 29666 90319790
Injection site vesicles 13.80 9.85 36 278955 4164 90345292
Vascular device infection 13.77 9.85 10 278981 11942 90337514
Lung diffusion disorder 13.75 9.85 7 278984 117 90349339
Intervertebral disc protrusion 13.71 9.85 136 278855 27060 90322396
Limb discomfort 13.61 9.85 178 278813 37882 90311574
Impaired work ability 13.58 9.85 104 278887 19222 90330234
Personality disorder 13.58 9.85 11 278980 12433 90337023
Functional residual capacity decreased 13.55 9.85 6 278985 72 90349384
Alcohol intolerance 13.54 9.85 7 278984 121 90349335
Quarantine 13.52 9.85 5 278986 36 90349420
Peritonitis 13.50 9.85 25 278966 19680 90329776
Sinonasal obstruction 13.49 9.85 9 278982 254 90349202
Mandibular mass 13.47 9.85 8 278983 183 90349273
Neurogenic shock 13.46 9.85 12 278979 524 90348932
Face oedema 13.45 9.85 120 278871 23198 90326258
Ageusia 13.32 9.85 90 278901 15986 90333470
Cold agglutinins positive 13.29 9.85 5 278986 38 90349418
Inhalation therapy 13.29 9.85 5 278986 38 90349418
Laryngeal oedema 13.28 9.85 49 278942 6832 90342624
Encephalitis 13.24 9.85 9 278982 11125 90338331
Pulmonary eosinophilia 13.23 9.85 10 278981 345 90349111
Infusion site mass 13.22 9.85 24 278967 2165 90347291
Pancreatic calcification 13.18 9.85 5 278986 39 90349417
Female reproductive neoplasm 13.18 9.85 5 278986 39 90349417
Eczema impetiginous 13.17 9.85 4 278987 14 90349442
Dry throat 13.17 9.85 54 278937 7906 90341550
Rotator cuff syndrome 13.12 9.85 89 278902 15830 90333626
Liver function test abnormal 13.12 9.85 97 278894 50748 90298708
Blood pressure systolic abnormal 13.09 9.85 25 278966 19453 90330003
Sputum retention 13.06 9.85 13 278978 653 90348803
Hypertonic bladder 13.00 9.85 36 278955 4312 90345144
Concussion 12.99 9.85 68 278923 11023 90338433
Systemic mastocytosis 12.99 9.85 8 278983 196 90349260
Administration site erythema 12.98 9.85 15 278976 894 90348562
Idiopathic urticaria 12.98 9.85 10 278981 355 90349101
Atrioventricular block first degree 12.92 9.85 5 278986 8506 90340950
Lip discolouration 12.92 9.85 13 278978 662 90348794
Skin disorder 12.85 9.85 171 278820 36535 90312921
Abdominal distension 12.80 9.85 305 278686 130296 90219160
Epstein-Barr virus infection 12.79 9.85 8 278983 10336 90339120
Drug level decreased 12.78 9.85 7 278984 9723 90339733
Dermatitis bullous 12.73 9.85 8 278983 10308 90339148
Formication 12.71 9.85 38 278953 4753 90344703
Lack of injection site rotation 12.69 9.85 15 278976 916 90348540
Homicidal ideation 12.69 9.85 21 278970 1759 90347697
Klebsiella infection 12.69 9.85 8 278983 10289 90339167
Cephalo-pelvic disproportion 12.63 9.85 8 278983 206 90349250
Miller Fisher syndrome 12.62 9.85 7 278984 140 90349316
Tongue discolouration 12.58 9.85 31 278960 3462 90345994
Musculoskeletal chest pain 12.58 9.85 120 278871 23630 90325826
Laryngitis 12.54 9.85 98 278893 50655 90298801
Pneumonia respiratory syncytial viral 12.53 9.85 18 278973 1333 90348123
Body mass index increased 12.52 9.85 19 278972 1478 90347978
Anaphylactoid reaction 12.39 9.85 36 278955 4432 90345024
Personality change 12.38 9.85 50 278941 7271 90342185
Hypovolaemia 12.35 9.85 12 278979 12419 90337037
Left ventricular failure 12.34 9.85 47 278944 6653 90342803
Pancreatitis relapsing 12.28 9.85 18 278973 1358 90348098
Animal scratch 12.27 9.85 21 278970 1809 90347647
Decubitus ulcer 12.21 9.85 11 278980 11802 90337654
Nausea 12.20 9.85 3135 275856 1107181 89242275
Blood immunoglobulin E 12.19 9.85 5 278986 49 90349407
Total lung capacity abnormal 12.19 9.85 6 278985 93 90349363
Painful respiration 12.18 9.85 28 278963 2990 90346466
Obsessive thoughts 12.17 9.85 12 278979 596 90348860
Skin toxicity 12.05 9.85 3 278988 6776 90342680
Disturbance in attention 12.05 9.85 208 278783 46901 90302555
Administration site pruritus 12.02 9.85 9 278982 306 90349150
Product packaging confusion 12.01 9.85 8 278983 225 90349231
Tachyphrenia 12.00 9.85 20 278971 1686 90347770
Respiratory fume inhalation disorder 11.95 9.85 7 278984 156 90349300
Vocal cord disorder 11.93 9.85 19 278972 1541 90347915
Blood creatinine increased 11.91 9.85 230 278761 101156 90248300
Injection site eczema 11.90 9.85 6 278985 98 90349358
Emotional disorder 11.86 9.85 83 278908 14914 90334542
Muscle rigidity 11.85 9.85 16 278975 14293 90335163
Bronchitis bacterial 11.85 9.85 15 278976 984 90348472
Nasal dryness 11.84 9.85 41 278950 5542 90343914
School refusal 11.83 9.85 3 278988 4 90349452
Upper gastrointestinal haemorrhage 11.83 9.85 34 278957 22942 90326514
Suicide attempt 11.82 9.85 310 278681 75089 90274367
Skin discolouration 11.82 9.85 197 278794 44118 90305338
Motor dysfunction 11.81 9.85 26 278965 19204 90330252
Hemiparesis 11.80 9.85 54 278937 31765 90317691
Calcium ionised increased 11.80 9.85 8 278983 232 90349224
Phlebectomy 11.76 9.85 5 278986 54 90349402
Distal intestinal obstruction syndrome 11.75 9.85 11 278980 512 90348944
Toxic skin eruption 11.73 9.85 19 278972 15755 90333701
Rabies 11.73 9.85 4 278987 22 90349434
Proctitis 11.71 9.85 18 278973 15241 90334215
Diffuse large B-cell lymphoma 11.68 9.85 6 278985 8639 90340817
Squamous cell carcinoma of the oral cavity 11.63 9.85 10 278981 416 90349040
Hot flush 11.59 9.85 252 278739 59236 90290220
Urticaria thermal 11.57 9.85 11 278980 522 90348934
Atrial fibrillation 11.51 9.85 318 278673 133293 90216163
Papule 11.49 9.85 52 278939 7950 90341506
Pleuritic pain 11.48 9.85 63 278928 10398 90339058
Malnutrition 11.47 9.85 25 278966 18533 90330923
Gastrectomy 11.43 9.85 14 278977 888 90348568
Laryngospasm 11.39 9.85 29 278962 3304 90346152
Nasal septum deviation 11.36 9.85 21 278970 1922 90347534
Conjunctivitis 11.33 9.85 129 278862 26577 90322879
Skin weeping 11.33 9.85 26 278965 2774 90346682
Immune system disorder 11.31 9.85 69 278922 11836 90337620
Breast conserving surgery 11.30 9.85 16 278975 1169 90348287
Serum sickness 11.27 9.85 30 278961 3512 90345944
Nerve compression 11.18 9.85 63 278928 10503 90338953
Cytomegalovirus infection reactivation 11.17 9.85 5 278986 7795 90341661
Screaming 11.17 9.85 31 278960 3719 90345737
Granulocytopenia 11.16 9.85 3 278988 6438 90343018
Hearing aid user 11.15 9.85 5 278986 62 90349394
Oesophagogastroduodenoscopy 11.13 9.85 7 278984 178 90349278
Parasomnia 11.11 9.85 12 278979 664 90348792
Peak expiratory flow rate increased 11.08 9.85 3 278988 6 90349450
Bruxism 11.01 9.85 34 278957 4329 90345127
Periarthritis 10.99 9.85 27 278964 3010 90346446
Congenital naevus 10.96 9.85 7 278984 183 90349273
Hypereosinophilic syndrome 10.96 9.85 9 278982 351 90349105
Aortic arteriosclerosis 10.89 9.85 5 278986 7679 90341777
Immune reconstitution inflammatory syndrome 10.86 9.85 4 278987 7015 90342441
Fungal pharyngitis 10.86 9.85 7 278984 186 90349270
Oliguria 10.86 9.85 10 278981 10614 90338842
Enterobiasis 10.82 9.85 6 278985 120 90349336
Hepatic enzyme abnormal 10.78 9.85 5 278986 7637 90341819
Red blood cell count increased 10.74 9.85 30 278961 3613 90345843
Weight decreased 10.72 9.85 1331 277660 378579 89970877
Neuropsychiatric syndrome 10.67 9.85 5 278986 69 90349387
Cytomegalovirus viraemia 10.65 9.85 5 278986 7581 90341875
Diverticulum oesophageal 10.63 9.85 7 278984 193 90349263
Haemorrhage intracranial 10.60 9.85 19 278972 15143 90334313
Anticholinergic syndrome 10.58 9.85 25 278966 2718 90346738
Peritoneal perforation 10.56 9.85 6 278985 126 90349330
Infusion site nodule 10.55 9.85 19 278972 1704 90347752
Faecaloma 10.45 9.85 10 278981 10421 90339035
Drug effect less than expected 10.44 9.85 42 278949 6096 90343360
Product distribution issue 10.42 9.85 30 278961 3675 90345781
Breast neoplasm 10.42 9.85 18 278973 1562 90347894
Deafness neurosensory 10.42 9.85 4 278987 6837 90342619
Intercepted product storage error 10.41 9.85 10 278981 481 90348975
Respiratory arrest 10.39 9.85 60 278931 33251 90316205
Agitated depression 10.37 9.85 9 278982 379 90349077
Lymphangiectasia 10.36 9.85 5 278986 74 90349382
Product dispensing error 10.34 9.85 69 278922 12204 90337252
Cerebral haemorrhage 10.34 9.85 63 278928 34459 90314997
Nasopharyngitis 10.31 9.85 1417 277574 405687 89943769
Anxiety disorder 10.31 9.85 36 278955 4886 90344570
Cockroach allergy 10.30 9.85 5 278986 75 90349381
Uterine cyst 10.24 9.85 10 278981 491 90348965
Hydronephrosis 10.13 9.85 14 278977 12388 90337068
Adverse food reaction 10.13 9.85 5 278986 78 90349378
Skin sensitisation 10.12 9.85 14 278977 1001 90348455
Injection site irritation 10.11 9.85 41 278950 5974 90343482
Forearm fracture 10.10 9.85 11 278980 614 90348842
Nasal pruritus 10.09 9.85 12 278979 738 90348718
Femoral neck fracture 10.03 9.85 10 278981 10223 90339233
Pain in extremity 10.01 9.85 1224 277767 449305 89900151
Chronic gastrointestinal bleeding 10.00 9.85 6 278985 140 90349316
Diabetes mellitus 9.96 9.85 266 278725 64609 90284847
Food craving 9.95 9.85 20 278971 1947 90347509
Foreign body in reproductive tract 9.93 9.85 15 278976 1162 90348294
Disability 9.91 9.85 79 278912 40666 90308790
Heart rate decreased 9.91 9.85 111 278880 53394 90296062
Retinal artery embolism 9.90 9.85 5 278986 82 90349374
Osteomyelitis 9.89 9.85 48 278943 27798 90321658
Troponin increased 9.88 9.85 16 278975 13265 90336191

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 3839.73 10.94 2239 107668 60075 42451353
Wheezing 1609.10 10.94 1244 108663 53537 42457891
Obstructive airways disorder 845.57 10.94 616 109291 24143 42487285
Eosinophilic granulomatosis with polyangiitis 807.17 10.94 410 109497 8228 42503200
Cough 617.02 10.94 1394 108513 176709 42334719
Full blood count abnormal 579.79 10.94 535 109372 29341 42482087
Dyspnoea 520.42 10.94 2384 107523 440237 42071191
Sleep disorder due to a general medical condition 510.72 10.94 396 109511 17057 42494371
Productive cough 496.64 10.94 638 109269 50929 42460499
Forced expiratory volume decreased 480.85 10.94 279 109628 7351 42504077
Abnormal behaviour 423.17 10.94 426 109481 26025 42485403
Toxicity to various agents 374.94 10.94 69 109838 229067 42282361
Suicidal ideation 362.55 10.94 529 109378 47632 42463796
Therapeutic product effect incomplete 358.04 10.94 650 109257 70289 42441139
Chest discomfort 328.78 10.94 589 109318 63027 42448401
Sleep terror 321.13 10.94 155 109752 2771 42508657
Nasal congestion 314.18 10.94 384 109523 29117 42482311
Acute kidney injury 312.40 10.94 293 109614 367044 42144384
Aggression 312.14 10.94 471 109436 43692 42467736
Anger 289.77 10.94 252 109655 12766 42498662
Sputum discoloured 287.92 10.94 226 109681 9906 42501522
Impaired quality of life 286.85 10.94 260 109647 13917 42497511
Loss of personal independence in daily activities 279.11 10.94 478 109429 49338 42462090
Sinusitis 275.84 10.94 462 109445 46830 42464598
Middle insomnia 274.31 10.94 198 109709 7635 42503793
Blood immunoglobulin E increased 259.22 10.94 144 109763 3481 42507947
Anxiety 248.89 10.94 771 109136 117789 42393639
Nasal polyps 245.76 10.94 142 109765 3709 42507719
Dermatitis atopic 234.45 10.94 219 109688 12185 42499243
Anaemia 233.98 10.94 227 109680 280051 42231377
Nightmare 233.63 10.94 305 109602 24707 42486721
Sleep disorder 229.08 10.94 430 109477 47665 42463763
Drug interaction 198.62 10.94 238 109669 266761 42244667
Depression 192.32 10.94 678 109229 110685 42400743
Febrile neutropenia 190.63 10.94 122 109785 185581 42325847
Mood altered 185.02 10.94 180 109727 10538 42500890
Thrombocytopenia 178.18 10.94 138 109769 190141 42321287
Asthma-chronic obstructive pulmonary disease overlap syndrome 169.31 10.94 82 109825 1477 42509951
Off label use 154.70 10.94 990 108917 637345 41874083
Urticaria 147.41 10.94 473 109434 73563 42437865
Pancytopenia 143.39 10.94 62 109845 117681 42393747
Gastrooesophageal reflux disease 142.73 10.94 341 109566 44682 42466746
Pulmonary function test abnormal 142.41 10.94 88 109819 2606 42508822
Pulmonary function test decreased 141.96 10.94 118 109789 5614 42505814
Bronchial wall thickening 140.10 10.94 69 109838 1291 42510137
Nasopharyngitis 139.47 10.94 505 109402 83491 42427937
Rhinorrhoea 136.35 10.94 272 109635 31522 42479906
Respiratory symptom 135.45 10.94 155 109752 10951 42500477
Death 132.48 10.94 696 109211 470489 42040939
Chronic obstructive pulmonary disease 131.84 10.94 410 109497 62704 42448724
Tic 128.92 10.94 79 109828 2304 42509124
Pulmonary vasculitis 128.86 10.94 116 109791 6150 42505278
Malignant neoplasm progression 127.42 10.94 60 109847 108340 42403088
Hypotension 120.94 10.94 307 109600 257324 42254104
Rhinitis allergic 120.74 10.94 91 109816 3751 42507677
Total lung capacity abnormal 119.56 10.94 96 109811 4347 42507081
Neutropenia 117.51 10.94 209 109698 199222 42312206
Bronchial hyperreactivity 117.45 10.94 69 109838 1860 42509568
Crying 117.19 10.94 111 109796 6283 42505145
Neuritis 114.04 10.94 108 109799 6112 42505316
Depressed mood 113.69 10.94 211 109696 23173 42488255
Bronchitis 112.19 10.94 321 109586 46880 42464548
Bronchial secretion retention 109.90 10.94 62 109845 1545 42509883
Irritability 105.77 10.94 228 109679 27900 42483528
Infective pulmonary exacerbation of cystic fibrosis 105.44 10.94 115 109792 7703 42503725
Dust allergy 104.34 10.94 96 109811 5236 42506192
Disease progression 102.49 10.94 132 109775 143524 42367904
Right atrial hypertrophy 102.49 10.94 46 109861 691 42510737
Eosinophil count increased 100.09 10.94 131 109776 10632 42500796
Vasculitis 99.66 10.94 174 109733 18220 42493208
Eosinophilia 97.67 10.94 243 109664 32656 42478772
Diarrhoea 96.40 10.94 745 109162 460104 42051324
Upper-airway cough syndrome 96.10 10.94 84 109823 4282 42507146
Social avoidant behaviour 95.48 10.94 75 109832 3289 42508139
Multiple organ dysfunction syndrome 95.09 10.94 67 109840 96968 42414460
Seasonal allergy 94.17 10.94 110 109797 7945 42503483
Dyspnoea exertional 94.03 10.94 314 109593 49834 42461594
Injection site pain 93.78 10.94 345 109562 57453 42453975
Respiratory tract congestion 93.36 10.94 107 109800 7571 42503857
Influenza 92.52 10.94 361 109546 61814 42449614
Septic shock 91.55 10.94 62 109845 91610 42419818
Sepsis 90.81 10.94 241 109666 199093 42312335
Lower respiratory tract infection 90.05 10.94 272 109635 40934 42470494
Spirometry abnormal 89.89 10.94 87 109820 5059 42506369
Sputum increased 88.65 10.94 70 109837 3093 42508335
Leukopenia 88.39 10.94 41 109866 74705 42436723
Insomnia 88.07 10.94 564 109343 117689 42393739
Attention deficit hyperactivity disorder 87.58 10.94 69 109838 3039 42508389
Upper respiratory tract infection 86.23 10.94 272 109635 41901 42469527
Obstruction 85.53 10.94 68 109839 3035 42508393
Confusional state 85.48 10.94 191 109716 167406 42344022
Discomfort 84.24 10.94 195 109712 25024 42486404
Myelosuppression 84.19 10.94 5 109902 40456 42470972
Renal failure 82.47 10.94 153 109754 143573 42367855
Neuropsychiatric symptoms 82.01 10.94 40 109867 732 42510696
Mood swings 81.41 10.94 107 109800 8719 42502709
Sneezing 81.32 10.94 91 109816 6272 42505156
Vital capacity decreased 80.71 10.94 35 109872 482 42510946
Drug abuse 80.29 10.94 91 109816 104680 42406748
Mite allergy 80.15 10.94 81 109826 4965 42506463
Conjunctivitis allergic 79.80 10.94 87 109820 5824 42505604
Sensitivity to weather change 79.29 10.94 55 109852 1988 42509440
Bronchospasm 79.25 10.94 129 109778 12756 42498672
Hypersensitivity 79.16 10.94 383 109524 71987 42439441
Blood creatinine increased 78.52 10.94 101 109806 109902 42401526
Breath sounds abnormal 78.39 10.94 124 109783 11969 42499459
Bronchiectasis 78.25 10.94 155 109752 17864 42493564
Hyponatraemia 77.89 10.94 88 109819 101374 42410054
Renal impairment 77.86 10.94 102 109805 110126 42401302
Rhabdomyolysis 77.59 10.94 53 109854 77966 42433462
Illness 77.03 10.94 187 109720 24743 42486685
Bronchial obstruction 75.33 10.94 50 109857 1679 42509749
Lung disorder 74.35 10.94 282 109625 47641 42463787
Ear infection 73.14 10.94 124 109783 12680 42498748
Mycotic allergy 73.13 10.94 76 109831 4815 42506613
Eosinophilic pneumonia chronic 72.64 10.94 28 109879 279 42511149
Solar lentigo 70.82 10.94 34 109873 600 42510828
Platelet count decreased 70.59 10.94 158 109749 138423 42373005
Right ventricular hypertrophy 70.33 10.94 46 109861 1506 42509922
Pruritus 70.25 10.94 770 109137 188001 42323427
Asthmatic crisis 69.65 10.94 32 109875 509 42510919
Sleep apnoea syndrome 68.82 10.94 164 109743 21444 42489984
Dehydration 67.91 10.94 167 109740 141600 42369828
Photodermatosis 67.85 10.94 35 109872 725 42510703
Ascites 67.14 10.94 31 109876 56647 42454781
Allergy to animal 66.04 10.94 31 109876 519 42510909
Haemoglobin decreased 65.87 10.94 153 109754 132318 42379110
Gastrointestinal haemorrhage 65.42 10.94 94 109813 97632 42413796
Dysplastic naevus 65.24 10.94 33 109874 655 42510773
Psychomotor hyperactivity 65.09 10.94 108 109799 10850 42500578
Eye pruritus 64.50 10.94 110 109797 11302 42500126
Blood cholesterol 64.41 10.94 24 109883 216 42511212
Neurological symptom 64.14 10.94 102 109805 9889 42501539
Obesity 62.54 10.94 134 109773 16325 42495103
Nausea 62.25 10.94 689 109218 396110 42115318
Product dose omission issue 61.77 10.94 639 109268 153726 42357702
Hyperkalaemia 61.51 10.94 70 109837 80388 42431040
Multiple allergies 61.34 10.94 61 109846 3667 42507761
Osteoporosis 60.88 10.94 125 109782 14781 42496647
Pulmonary alveolar haemorrhage 60.22 10.94 124 109783 14692 42496736
Rhinitis 59.37 10.94 109 109798 11868 42499560
Vocal cord dysfunction 59.24 10.94 22 109885 196 42511232
Forced vital capacity decreased 58.22 10.94 34 109873 906 42510522
Coma 57.91 10.94 33 109874 53521 42457907
Completed suicide 56.82 10.94 101 109806 96364 42415064
Screaming 56.54 10.94 44 109863 1903 42509525
Bronchopulmonary aspergillosis allergic 55.77 10.94 64 109843 4534 42506894
Victim of child abuse 55.74 10.94 36 109871 1153 42510275
Cardiac arrest 54.55 10.94 126 109781 109194 42402234
Serotonin syndrome 54.36 10.94 3 109904 25842 42485586
Hypokalaemia 54.17 10.94 63 109844 71658 42439770
Bone marrow failure 53.92 10.94 10 109897 33083 42478345
Heart rate increased 53.37 10.94 275 109632 52980 42458448
Antineutrophil cytoplasmic antibody positive 53.36 10.94 61 109846 4304 42507124
Nasal disorder 53.19 10.94 43 109864 1966 42509462
Epidural lipomatosis 52.97 10.94 41 109866 1759 42509669
Panic attack 52.85 10.94 99 109808 10946 42500482
Agranulocytosis 52.65 10.94 8 109899 30604 42480824
Smoke sensitivity 52.54 10.94 20 109887 192 42511236
Product use in unapproved indication 52.34 10.94 715 109192 183741 42327687
Headache 51.45 10.94 885 109022 238484 42272944
Chronic sinusitis 51.24 10.94 53 109854 3339 42508089
Intentional overdose 51.09 10.94 35 109872 51421 42460007
Throat clearing 51.04 10.94 27 109880 590 42510838
Cardiac failure 50.28 10.94 127 109780 106729 42404699
C-reactive protein increased 50.00 10.94 54 109853 63506 42447922
Perfume sensitivity 49.73 10.94 18 109889 148 42511280
Metabolic acidosis 49.23 10.94 37 109870 51821 42459607
Sinus disorder 48.70 10.94 80 109827 7970 42503458
Oropharyngeal pain 48.65 10.94 228 109679 42282 42469146
Tubulointerstitial nephritis 48.37 10.94 11 109896 31537 42479891
Eye disorder 48.16 10.94 98 109809 11514 42499914
Anosmia 48.12 10.94 63 109844 5113 42506315
Educational problem 46.99 10.94 25 109882 553 42510875
Chest X-ray abnormal 46.86 10.94 58 109849 4450 42506978
Blood pressure systolic increased 46.23 10.94 168 109739 27800 42483628
Personality change 46.17 10.94 65 109842 5654 42505774
Injection site swelling 45.84 10.94 121 109786 16852 42494576
Electrocardiogram QT prolonged 45.78 10.94 34 109873 47911 42463517
Suffocation feeling 45.51 10.94 26 109881 664 42510764
Eye swelling 45.23 10.94 97 109810 11823 42499605
Product dose omission in error 45.21 10.94 79 109828 8275 42503153
Aortic valve stenosis 45.13 10.94 47 109860 2985 42508443
Aspirin-exacerbated respiratory disease 45.01 10.94 20 109887 293 42511135
Monocyte chemotactic protein-1 increased 44.99 10.94 21 109886 347 42511081
Alpha tumour necrosis factor increased 44.72 10.94 21 109886 352 42511076
Neoplasm progression 44.68 10.94 10 109897 28990 42482438
Cardiogenic shock 44.58 10.94 18 109889 35622 42475806
Cytomegalovirus infection 44.36 10.94 14 109893 32292 42479136
Generalised anxiety disorder 43.10 10.94 28 109879 906 42510522
Respiratory disorder 42.91 10.94 140 109767 21945 42489483
Eosinophil count 42.86 10.94 17 109890 184 42511244
Sedation 42.22 10.94 13 109894 30462 42480966
Foetal exposure during pregnancy 42.10 10.94 36 109871 47275 42464153
Delirium 42 10.94 44 109863 52475 42458953
Acute myocardial infarction 41.90 10.94 53 109854 58112 42453316
Peak expiratory flow rate decreased 41.69 10.94 15 109892 121 42511307
Dyspnoea at rest 41.51 10.94 53 109854 4196 42507232
Constipation 41.39 10.94 247 109660 162044 42349384
Encephalopathy 41.18 10.94 28 109879 41305 42470123
Pleural effusion 40.84 10.94 122 109785 97044 42414384
Cardio-respiratory arrest 40.63 10.94 55 109852 58581 42452847
Pulmonary fibrosis 40.54 10.94 156 109751 26525 42484903
Reversible airways obstruction 40.52 10.94 23 109884 580 42510848
Sinus congestion 40.40 10.94 68 109839 6912 42504516
Myocardial infarction 39.98 10.94 174 109733 123835 42387593
Haemoptysis 39.91 10.94 229 109678 45938 42465490
Juvenile idiopathic arthritis 39.44 10.94 41 109866 2598 42508830
Child abuse 39.36 10.94 26 109881 866 42510562
Rhinitis perennial 39.24 10.94 16 109891 187 42511241
Negative thoughts 39.22 10.94 24 109883 698 42510730
Bradycardia 39.13 10.94 103 109804 85381 42426047
Prolonged expiration 38.47 10.94 18 109889 299 42511129
Neuroleptic malignant syndrome 38.36 10.94 5 109902 21467 42489961
Sinus polyp 38.32 10.94 17 109890 248 42511180
Alanine aminotransferase increased 37.87 10.94 110 109797 88296 42423132
Mucosal inflammation 37.68 10.94 43 109864 49331 42462097
Melaena 37.61 10.94 27 109880 38719 42472709
Stomatitis 37.15 10.94 45 109862 50284 42461144
Sputum purulent 36.98 10.94 23 109884 689 42510739
Neurotoxicity 36.75 10.94 8 109899 23643 42487785
Product quality issue 36.23 10.94 115 109792 17767 42493661
Decreased appetite 36.19 10.94 321 109586 192816 42318612
Respiratory tract infection 36.06 10.94 149 109758 26173 42485255
Food allergy 35.91 10.94 36 109871 2185 42509243
Homicidal ideation 35.78 10.94 40 109867 2754 42508674
International normalised ratio increased 35.63 10.94 43 109864 48125 42463303
Eczema 35.53 10.94 178 109729 33908 42477520
General physical health deterioration 35.07 10.94 237 109670 151009 42360419
Lactic acidosis 34.99 10.94 39 109868 45222 42466206
Hypoglycaemia 34.93 10.94 63 109844 59791 42451637
Hypoventilation 34.92 10.94 46 109861 3756 42507672
Syncope 34.84 10.94 135 109772 99271 42412157
Pyrexia 34.82 10.94 763 109144 393279 42118149
Rheumatoid arthritis 34.56 10.94 35 109872 42405 42469023
Exposure via skin contact 34.52 10.94 53 109854 4985 42506443
Major depression 34.50 10.94 55 109852 5343 42506085
Adjustment disorder 34.01 10.94 28 109879 1314 42510114
Restrictive pulmonary disease 33.62 10.94 28 109879 1335 42510093
Behaviour disorder 33.46 10.94 63 109844 6991 42504437
Throat irritation 33.25 10.94 91 109816 12945 42498483
Emotional disorder 33.25 10.94 59 109848 6255 42505173
Blood bilirubin increased 33.11 10.94 36 109871 42216 42469212
Dysphonia 32.85 10.94 153 109754 28297 42483131
Haematochezia 32.78 10.94 63 109844 58373 42453055
Nasal discharge discolouration 32.78 10.94 18 109889 425 42511003
Nasal inflammation 32.78 10.94 18 109889 425 42511003
Intervertebral disc degeneration 32.74 10.94 64 109843 7303 42504125
Suicidal behaviour 32.54 10.94 29 109878 1517 42509911
Intentional product use issue 32.53 10.94 87 109820 71746 42439682
Morbid thoughts 32.34 10.94 14 109893 192 42511236
Aspartate aminotransferase increased 32.33 10.94 97 109810 77066 42434362
Secretion discharge 32.33 10.94 65 109842 7570 42503858
Therapeutic response shortened 32.01 10.94 92 109815 13462 42497966
Status asthmaticus 31.98 10.94 16 109891 310 42511118
Eye irritation 31.91 10.94 82 109825 11236 42500192
Anaphylactic reaction 31.85 10.94 204 109703 42539 42468889
Drug resistance 31.78 10.94 25 109882 34223 42477205
Acute myeloid leukaemia 31.73 10.94 9 109898 22247 42489181
Vomiting 31.67 10.94 541 109366 289182 42222246
Self-injurious ideation 31.54 10.94 31 109876 1837 42509591
Body temperature decreased 31.34 10.94 95 109812 14318 42497110
Interstitial lung disease 31.20 10.94 101 109806 78361 42433067
Injection site pruritus 30.61 10.94 72 109835 9333 42502095
Capillaritis 30.44 10.94 33 109874 2195 42509233
Hepatic failure 30.37 10.94 32 109875 38068 42473360
Neutropenic sepsis 30.27 10.94 3 109904 15943 42495485
Palmar-plantar erythrodysaesthesia syndrome 29.95 10.94 8 109899 20574 42490854
Drug reaction with eosinophilia and systemic symptoms 29.62 10.94 39 109868 42036 42469392
Hostility 29.49 10.94 21 109886 792 42510636
Fear 29.44 10.94 78 109829 10887 42500541
Obsessive-compulsive disorder 29.27 10.94 58 109849 6685 42504743
Dysphemia 29.24 10.94 30 109877 1872 42509556
White blood cell count decreased 29.21 10.94 166 109741 110230 42401198
Sleep talking 29.16 10.94 19 109888 618 42510810
Respiratory rate increased 29.00 10.94 78 109829 10984 42500444
Snoring 28.93 10.94 43 109864 3930 42507498
Dysmetropsia 28.93 10.94 8 109899 23 42511405
Cerebral haemorrhage 28.59 10.94 35 109872 38931 42472497
Haematuria 28.51 10.94 67 109840 57732 42453696
Lymphopenia 28.46 10.94 10 109897 21553 42489875
Contraindicated product administered 28.15 10.94 15 109892 25257 42486171
Nasal discomfort 28.11 10.94 27 109880 1555 42509873
Ocular discomfort 28.10 10.94 37 109870 3020 42508408
Blood test abnormal 28.00 10.94 85 109822 12821 42498607
Pneumocystis jirovecii pneumonia 27.97 10.94 15 109892 25166 42486262
Nasal oedema 27.94 10.94 15 109892 338 42511090
Asthma exercise induced 27.74 10.94 11 109896 119 42511309
Asthenia 27.64 10.94 534 109373 280259 42231169
Blood pressure increased 27.61 10.94 392 109515 101536 42409892
Depressed level of consciousness 27.54 10.94 51 109856 47919 42463509
Endocarditis fibroplastica 27.43 10.94 7 109900 13 42511415
Interleukin level increased 27.37 10.94 21 109886 889 42510539
Oesophageal polyp 27.29 10.94 9 109898 54 42511374
Normochromic normocytic anaemia 27.10 10.94 67 109840 8964 42502464
Morose 27.09 10.94 7 109900 14 42511414
Hypereosinophilic syndrome 26.95 10.94 16 109891 440 42510988
Affective disorder 26.76 10.94 52 109855 5908 42505520
Acute respiratory distress syndrome 26.67 10.94 23 109884 30085 42481343
Extrapyramidal disorder 26.65 10.94 5 109902 16407 42495021
Unresponsive to stimuli 26.61 10.94 25 109882 31378 42480050
Hyperbilirubinaemia 26.50 10.94 10 109897 20625 42490803
Eosinophilic bronchitis 26.40 10.94 13 109894 243 42511185
Clostridium difficile colitis 26.15 10.94 11 109896 21241 42490187
Treatment failure 26.04 10.94 79 109828 62545 42448883
Abdominal pain 25.84 10.94 341 109566 190130 42321298
Stiff person syndrome 25.83 10.94 12 109895 196 42511232
Drug level increased 25.77 10.94 18 109889 26182 42485246
Pleural thickening 25.67 10.94 16 109891 481 42510947
Cystic fibrosis 25.59 10.94 29 109878 2026 42509402
Diastolic dysfunction 25.55 10.94 56 109851 6927 42504501
Temperature intolerance 25.55 10.94 45 109862 4743 42506685
Ventricular fibrillation 25.50 10.94 24 109883 30099 42481329
Lung hyperinflation 25.37 10.94 22 109885 1109 42510319
Overdose 25.37 10.94 163 109744 105101 42406327
Cerebrovascular accident 25.21 10.94 147 109760 97013 42414415
Blebitis 25.16 10.94 6 109901 7 42511421
Attention-seeking behaviour 25.15 10.94 8 109899 42 42511386
Hepatotoxicity 25.14 10.94 17 109890 25150 42486278
Injection site bruising 25.09 10.94 76 109831 11449 42499979
Nasal septum deviation 24.98 10.94 23 109884 1255 42510173
Shock 24.89 10.94 23 109884 29098 42482330
Deep vein thrombosis 24.78 10.94 108 109799 76849 42434579
Accidental overdose 24.66 10.94 22 109885 28308 42483120
Dry eye 24.66 10.94 92 109815 15414 42496014
Haematemesis 24.48 10.94 25 109882 30174 42481254
Pigment dispersion syndrome 24.30 10.94 6 109901 9 42511419
Panic reaction 24.29 10.94 26 109881 1704 42509724
Pneumonia 24.25 10.94 1325 108582 420824 42090604
Tearfulness 24.23 10.94 37 109870 3463 42507965
Dry skin 24.22 10.94 210 109697 48128 42463300
Rash maculo-papular 24.18 10.94 37 109870 37466 42473962
Altered state of consciousness 23.97 10.94 24 109883 29235 42482193
Sopor 23.76 10.94 3 109904 13199 42498229
Ischaemic stroke 23.60 10.94 14 109893 22219 42489209
Blood urea increased 23.49 10.94 30 109877 32763 42478665
Respiratory tract irritation 23.48 10.94 13 109894 312 42511116
Renal tubular necrosis 23.40 10.94 9 109898 18345 42493083
Abnormal dreams 23.39 10.94 60 109847 8211 42503217
Enuresis 23.33 10.94 32 109875 2716 42508712
Intentional self-injury 23.19 10.94 89 109818 15113 42496315
Ocular hyperaemia 23.17 10.94 92 109815 15871 42495557
Dysarthria 23.13 10.94 42 109865 39765 42471663
Mast cell activation syndrome 23.00 10.94 13 109894 325 42511103
Hyperkaliuria 22.89 10.94 9 109898 95 42511333
Urinary tract infection 22.78 10.94 156 109751 99128 42412300
Hypercalcaemia 22.78 10.94 9 109898 18049 42493379
Status epilepticus 22.77 10.94 6 109901 15572 42495856
Blood lactic acid 22.72 10.94 13 109894 333 42511095
Benign prostatic hyperplasia 22.69 10.94 111 109796 20941 42490487
Self esteem decreased 22.51 10.94 15 109892 507 42510921
Bronchopulmonary aspergillosis 22.43 10.94 11 109896 19418 42492010
Neutrophil count decreased 22.29 10.94 86 109821 63329 42448099
Forced expiratory volume abnormal 22.13 10.94 7 109900 36 42511392
Excessive eye blinking 21.93 10.94 16 109891 627 42510801
Polyp 21.63 10.94 41 109866 4573 42506855
Respiration abnormal 21.58 10.94 38 109869 4004 42507424
Rhonchi 21.56 10.94 27 109880 2096 42509332
Throat tightness 21.56 10.94 64 109843 9535 42501893
NPM1 gene mutation 21.22 10.94 9 109898 117 42511311
Bronchiolitis 21.22 10.94 37 109870 3869 42507559
Rectal haemorrhage 21.03 10.94 62 109845 49544 42461884
Tumour lysis syndrome 20.92 10.94 16 109891 22215 42489213
Sputum abnormal 20.89 10.94 15 109892 573 42510855
Cytokine release syndrome 20.87 10.94 53 109854 44474 42466954
Electrolyte imbalance 20.80 10.94 9 109898 17092 42494336
Somnambulism 20.74 10.94 34 109873 3381 42508047
Disseminated intravascular coagulation 20.70 10.94 20 109887 24774 42486654
Lower respiratory tract congestion 20.65 10.94 23 109884 1577 42509851
Shock haemorrhagic 20.65 10.94 8 109899 16234 42495194
Meningitis eosinophilic 20.59 10.94 6 109901 22 42511406
Hyperglycaemia 20.41 10.94 56 109851 45803 42465625
Inappropriate schedule of product administration 20.33 10.94 354 109553 95548 42415880
Allergic respiratory disease 20.31 10.94 7 109900 49 42511379
Hypothyroidism 20.25 10.94 147 109760 31937 42479491
Physical assault 20.24 10.94 19 109888 1063 42510365
Scratch 20.18 10.94 43 109864 5218 42506210
Sleep paralysis 20.08 10.94 12 109895 334 42511094
Haemodynamic instability 20.02 10.94 4 109903 12553 42498875
Miosis 19.99 10.94 5 109902 13441 42497987
Facial discomfort 19.97 10.94 8 109899 89 42511339
Blood phosphorus increased 19.95 10.94 4 109903 12521 42498907
Colitis 19.90 10.94 58 109849 46514 42464914
Diaphragmatic disorder 19.88 10.94 20 109887 1219 42510209
Sinus operation 19.84 10.94 17 109890 843 42510585
Angina pectoris 19.76 10.94 34 109873 32862 42478566
Decreased activity 19.73 10.94 42 109865 5093 42506335
Nodule 19.63 10.94 74 109833 12460 42498968
Joint warmth 19.61 10.94 15 109892 632 42510796
Mononeuropathy 19.57 10.94 11 109896 272 42511156
Pulmonary oedema 19.53 10.94 71 109836 53201 42458227
Lung diffusion test decreased 19.52 10.94 17 109890 862 42510566
Hepatic encephalopathy 19.46 10.94 9 109898 16433 42494995
Hypomagnesaemia 19.45 10.94 27 109880 28461 42482967
Oedema peripheral 19.41 10.94 241 109666 135835 42375593
Duodenal ulcer 19.39 10.94 4 109903 12275 42499153
Exercise tolerance decreased 19.27 10.94 46 109861 6020 42505408
Metastases to liver 19.22 10.94 9 109898 16317 42495111
Acute hepatic failure 19.21 10.94 10 109897 17063 42494365
Pulmonary congestion 19.20 10.94 86 109821 15644 42495784
Incorrect dose administered 19.15 10.94 215 109692 52759 42458669
Kidney infection 19.03 10.94 49 109858 6721 42504707
Hepatic cytolysis 18.77 10.94 25 109882 26819 42484609
Hepatic function abnormal 18.73 10.94 69 109838 51498 42459930
Hypohidrosis 18.72 10.94 10 109897 223 42511205
Circulatory collapse 18.67 10.94 20 109887 23616 42487812
Proteinuria 18.66 10.94 19 109888 22964 42488464
Device related infection 18.57 10.94 15 109892 20264 42491164
Intestinal perforation 18.34 10.94 3 109904 10871 42500557
Arteritis coronary 18.32 10.94 7 109900 68 42511360
Myelodysplastic syndrome 18.24 10.94 19 109888 22726 42488702
Blood immunoglobulin G decreased 18.24 10.94 26 109881 2288 42509140
Product substitution issue 17.96 10.94 67 109840 11223 42500205
Precancerous condition 17.95 10.94 8 109899 118 42511310
Fall 17.91 10.94 464 109443 234056 42277372
Emphysema 17.81 10.94 69 109838 11766 42499662
Subdural haematoma 17.81 10.94 20 109887 23118 42488310
Hypercholesterolaemia 17.80 10.94 73 109834 12776 42498652
Malaise 17.79 10.94 692 109215 211464 42299964
Sinus bradycardia 17.78 10.94 8 109899 14845 42496583
Upper respiratory tract congestion 17.76 10.94 17 109890 975 42510453
Frustration tolerance decreased 17.68 10.94 31 109876 3255 42508173
Drug-induced liver injury 17.59 10.94 46 109861 38227 42473201
Haematocrit decreased 17.58 10.94 40 109867 34868 42476560
Pathogen resistance 17.53 10.94 4 109903 11446 42499982
Medication error 17.52 10.94 37 109870 33117 42478311
Alopecia areata 17.41 10.94 11 109896 339 42511089
Violence-related symptom 17.39 10.94 13 109894 529 42510899
Lymphocyte count decreased 17.39 10.94 28 109879 27781 42483647
Chronic graft versus host disease 17.34 10.94 44 109863 5981 42505447
Quality of life decreased 17.33 10.94 41 109866 5335 42506093
Small airways disease 17.29 10.94 6 109901 43 42511385
Cytomegalovirus viraemia 17.20 10.94 3 109904 10374 42501054
Oropharyngeal discomfort 17.18 10.94 35 109872 4114 42507314
Bronchitis viral 17.14 10.94 10 109897 266 42511162
Mastication disorder 17.11 10.94 22 109885 1754 42509674
Nasal mucosal disorder 17.04 10.94 8 109899 134 42511294
Injection site urticaria 17.03 10.94 31 109876 3352 42508076
Arteriosclerosis coronary artery 17.03 10.94 94 109813 18583 42492845
Post-traumatic stress disorder 17.03 10.94 25 109882 2260 42509168
Subarachnoid haemorrhage 17.00 10.94 8 109899 14464 42496964
Lower respiratory tract infection bacterial 16.93 10.94 13 109894 551 42510877
Eosinophil count abnormal 16.90 10.94 11 109896 357 42511071
Gastroenteritis viral 16.85 10.94 53 109854 8146 42503282
Peritonitis 16.79 10.94 14 109893 18619 42492809
Transplant rejection 16.77 10.94 7 109900 13581 42497847
Febrile bone marrow aplasia 16.75 10.94 3 109904 10178 42501250
Hyperthyroidism 16.74 10.94 8 109899 14333 42497095
Renal oncocytoma 16.72 10.94 9 109898 204 42511224
Upper gastrointestinal haemorrhage 16.70 10.94 33 109874 30266 42481162
Prostatomegaly 16.64 10.94 44 109863 6133 42505295
Gastrointestinal tract mucosal pigmentation 16.63 10.94 13 109894 566 42510862
Fight in school 16.62 10.94 4 109903 5 42511423
Chronic spontaneous urticaria 16.62 10.94 10 109897 282 42511146
Mental disorder 16.62 10.94 91 109816 17938 42493490
Diabetic ketoacidosis 16.50 10.94 20 109887 22347 42489081
Lacrimation increased 16.45 10.94 67 109840 11691 42499737
Nasal turbinate abnormality 16.30 10.94 6 109901 52 42511376
Eosinophilic oesophagitis 16.28 10.94 14 109893 698 42510730
Low birth weight baby 16.23 10.94 3 109904 9952 42501476
Carboxyhaemoglobin increased 16.20 10.94 6 109901 53 42511375
Bronchial disorder 16.19 10.94 19 109888 1379 42510049
Therapeutic response decreased 16.11 10.94 156 109751 36856 42474572
Blood creatine phosphokinase increased 16.07 10.94 67 109840 48271 42463157
Nocturnal dyspnoea 16.07 10.94 13 109894 595 42510833
Bronchiolitis obliterans syndrome 16.04 10.94 10 109897 301 42511127
Chronic kidney disease 16.00 10.94 65 109842 47176 42464252
Nephropathy toxic 15.99 10.94 12 109895 16826 42494602
Respiratory depression 15.91 10.94 93 109814 18775 42492653
Anuria 15.83 10.94 5 109902 11527 42499901
Premature baby 15.75 10.94 22 109885 23131 42488297
Parkinsonism 15.70 10.94 4 109903 10619 42500809
Acidosis 15.69 10.94 6 109901 12273 42499155
Ejection fraction abnormal 15.66 10.94 18 109889 1277 42510151
Hypoacusis 15.66 10.94 92 109815 18610 42492818
Scleroderma 15.54 10.94 21 109886 1757 42509671
Intermittent explosive disorder 15.48 10.94 4 109903 8 42511420
Atrioventricular block complete 15.47 10.94 5 109902 11359 42500069
Adjustment disorder with depressed mood 15.42 10.94 11 109896 416 42511012
Prostate cancer 15.39 10.94 61 109846 44582 42466846
Liver injury 15.35 10.94 16 109891 19132 42492296
Conjunctivitis 15.24 10.94 70 109837 12869 42498559
Posterior reversible encephalopathy syndrome 15.20 10.94 7 109900 12814 42498614
Enterococcal infection 15.19 10.94 6 109901 12033 42499395
Photosensitivity reaction 15.17 10.94 69 109838 12633 42498795
Forced expiratory flow decreased 15.16 10.94 8 109899 174 42511254
Metastases to central nervous system 15.11 10.94 4 109903 10351 42501077
Immune effector cell-associated neurotoxicity syndrome 15.11 10.94 3 109904 9458 42501970
Chimerism 15.11 10.94 9 109898 249 42511179
Brain oedema 15.04 10.94 12 109895 16315 42495113
Disease prodromal stage 15.03 10.94 5 109902 31 42511397
Hypoalbuminaemia 14.99 10.94 11 109896 15599 42495829
Gamma-glutamyltransferase increased 14.98 10.94 39 109868 32458 42478970
Intestinal ischaemia 14.95 10.94 3 109904 9385 42502043
Labelled drug-drug interaction medication error 14.93 10.94 11 109896 15571 42495857
Feeling abnormal 14.93 10.94 258 109649 69528 42441900
Myositis 14.90 10.94 10 109897 14856 42496572
Seizure anoxic 14.89 10.94 3 109904 0 42511428
ACTH stimulation test abnormal 14.89 10.94 3 109904 0 42511428
Autophobia 14.89 10.94 3 109904 0 42511428
Migraine without aura 14.89 10.94 3 109904 0 42511428
Exophthalmos congenital 14.89 10.94 3 109904 0 42511428
Cephalo-pelvic disproportion 14.89 10.94 3 109904 0 42511428
Pigmentary glaucoma 14.89 10.94 3 109904 0 42511428
Metastases to bone 14.79 10.94 10 109897 14799 42496629
Hypertensive crisis 14.78 10.94 4 109903 10202 42501226
Therapy non-responder 14.78 10.94 79 109828 53280 42458148
Cytopenia 14.74 10.94 14 109893 17483 42493945
Lung hernia 14.65 10.94 6 109901 71 42511357
Gout 14.64 10.94 123 109784 27932 42483496
Hemiparesis 14.53 10.94 14 109893 17362 42494066
Ear discomfort 14.47 10.94 29 109878 3370 42508058
Hyposmia 14.45 10.94 10 109897 360 42511068
Stress 14.45 10.94 176 109731 44036 42467392
Idiopathic intracranial hypertension 14.43 10.94 14 109893 816 42510612
Encephalitis 14.43 10.94 3 109904 9155 42502273
Cognitive disorder 14.28 10.94 43 109864 34129 42477299
Neuropsychiatric syndrome 14.21 10.94 7 109900 131 42511297
Steroid diabetes 14.19 10.94 26 109881 2826 42508602
Mycobacterial infection 14.14 10.94 25 109882 2643 42508785
Jaundice 14.11 10.94 44 109863 34545 42476883
Clavicle fracture 14.04 10.94 25 109882 2658 42508770
Social anxiety disorder 14.03 10.94 12 109895 594 42510834
Pharyngitis streptococcal 13.96 10.94 31 109876 3869 42507559
Weight increased 13.95 10.94 371 109536 107612 42403816
Frequent bowel movements 13.91 10.94 21 109886 21386 42490042
Glomerular filtration rate decreased 13.87 10.94 13 109894 16338 42495090
Escherichia infection 13.86 10.94 6 109901 11390 42500038
Bipolar disorder 13.84 10.94 31 109876 3891 42507537
Agitation 13.84 10.94 238 109669 64076 42447352
Disturbance in social behaviour 13.83 10.94 20 109887 1783 42509645
Hypervolaemia 13.80 10.94 24 109883 23101 42488327
Administration site reaction 13.50 10.94 6 109901 88 42511340
Bone density decreased 13.45 10.94 22 109885 2184 42509244
Eosinophilic pneumonia 13.42 10.94 35 109872 4839 42506589
Cytomegalovirus infection reactivation 13.41 10.94 6 109901 11172 42500256
Poor quality sleep 13.37 10.94 54 109853 9386 42502042
Liver function test abnormal 13.36 10.94 41 109866 32350 42479078
Painful respiration 13.25 10.94 17 109890 1352 42510076
Dacryostenosis congenital 13.23 10.94 5 109902 47 42511381
Hospitalisation 13.20 10.94 267 109640 74063 42437365
Basal cell carcinoma 13.19 10.94 24 109883 22709 42488719
Colitis ulcerative 13.18 10.94 30 109877 26145 42485283
Prescribed underdose 13.18 10.94 5 109902 10277 42501151
Cortisol decreased 13.16 10.94 17 109890 1361 42510067
Urinary retention 13.13 10.94 60 109847 42154 42469274
Oesophagitis 13.08 10.94 12 109895 15235 42496193
Injection site erythema 13.01 10.94 93 109814 20102 42491326
Immune reconstitution inflammatory syndrome 12.89 10.94 5 109902 10138 42501290
Poisoning deliberate 12.87 10.94 5 109902 10129 42501299
Reaction to colouring 12.82 10.94 3 109904 3 42511425
Pulseless electrical activity 12.81 10.94 3 109904 8434 42502994
Cronobacter infection 12.74 10.94 4 109903 20 42511408
Sputum retention 12.70 10.94 12 109895 677 42510751
Hypophagia 12.69 10.94 32 109875 26924 42484504
Urosepsis 12.67 10.94 12 109895 15008 42496420
Cholecystitis 12.67 10.94 9 109898 12979 42498449
Appendicitis 12.66 10.94 21 109886 20592 42490836
Lymphoma 12.61 10.94 11 109896 14310 42497118
Ventricular tachycardia 12.56 10.94 38 109869 30122 42481306
Vasomotor rhinitis 12.53 10.94 5 109902 55 42511373
Tachypnoea 12.46 10.94 23 109884 21639 42489789
Hepatitis 12.40 10.94 33 109874 27267 42484161
Metastases to lung 12.40 10.94 7 109900 11417 42500011
Bacteraemia 12.36 10.94 29 109878 25011 42486417
Separation anxiety disorder 12.36 10.94 3 109904 4 42511424
Glaucoma 12.34 10.94 48 109859 8200 42503228
Caput succedaneum 12.24 10.94 6 109901 111 42511317
Lethargy 12.13 10.94 71 109836 46819 42464609
Dialysis 12.10 10.94 8 109899 11978 42499450
Osteonecrosis of jaw 12.08 10.94 19 109888 19030 42492398
Gastric haemorrhage 12.07 10.94 6 109901 10509 42500919
Expiratory reserve volume decreased 12.05 10.94 6 109901 115 42511313
Epstein-Barr virus infection 12.00 10.94 5 109902 9713 42501715
Stridor 12.00 10.94 24 109883 2784 42508644
Abnormal sleep-related event 11.95 10.94 10 109897 480 42510948
Tachycardia 11.92 10.94 186 109721 100901 42410527
Drug dependence 11.87 10.94 121 109786 28973 42482455
Allergy to plants 11.86 10.94 4 109903 26 42511402
Central obesity 11.85 10.94 12 109895 737 42510691
Myoclonus 11.82 10.94 16 109891 17049 42494379
Splenomegaly 11.79 10.94 16 109891 17031 42494397
Atrioventricular block 11.79 10.94 5 109902 9610 42501818
Haemophilus infection 11.77 10.94 17 109890 1514 42509914
Hallucination 11.72 10.94 211 109696 57296 42454132
Onychophagia 11.72 10.94 5 109902 66 42511362
Erythema 11.63 10.94 365 109542 108428 42403000
Prostatic specific antigen increased 11.59 10.94 16 109891 16909 42494519
Hyperammonaemia 11.55 10.94 3 109904 7863 42503565
Anal abscess 11.52 10.94 3 109904 7847 42503581
Terminal insomnia 11.50 10.94 13 109894 906 42510522
Hepatic enzyme increased 11.48 10.94 70 109837 45714 42465714
Hypovolaemic shock 11.45 10.94 4 109903 8655 42502773
Mononeuropathy multiplex 11.42 10.94 10 109897 511 42510917
Viral myelitis 11.39 10.94 5 109902 71 42511357
Reflux laryngitis 11.39 10.94 6 109901 130 42511298
Bipolar II disorder 11.37 10.94 4 109903 30 42511398
Acne 11.34 10.94 67 109840 13577 42497851
Leukocytosis 11.28 10.94 39 109868 29669 42481759
Skin irritation 11.27 10.94 44 109863 7530 42503898
Immunosuppressant drug level increased 11.26 10.94 3 109904 7728 42503700
Rash 11.22 10.94 844 109063 276110 42235318
Oliguria 11.17 10.94 5 109902 9308 42502120
Actinic keratosis 11.14 10.94 34 109873 5142 42506286
Arteriosclerosis 11.11 10.94 82 109825 17907 42493521
Blood glucose increased 11.08 10.94 129 109778 73570 42437858
Delusion 11.06 10.94 13 109894 14721 42496707
Joint swelling 11.05 10.94 117 109790 67905 42443523
Respiratory arrest 11.01 10.94 37 109870 28387 42483041

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 8668.19 9.74 6533 310517 243758 110028491
Wheezing 3243.12 9.74 3822 313228 251408 110020841
Cough 2057.13 9.74 4260 312790 457381 109814868
Obstructive airways disorder 1827.90 9.74 1310 315740 44839 110227410
Dyspnoea 1825.57 9.74 7112 309938 1099760 109172489
Eosinophilic granulomatosis with polyangiitis 1715.16 9.74 761 316289 9925 110262324
Full blood count abnormal 1389.19 9.74 1207 315843 54845 110217404
Productive cough 1245.11 9.74 1586 315464 112719 110159530
Sputum discoloured 1112.64 9.74 796 316254 27149 110245100
Forced expiratory volume decreased 1015.20 9.74 570 316480 12606 110259643
Chest discomfort 931.22 9.74 1736 315314 172112 110100137
Sleep disorder due to a general medical condition 893.57 9.74 915 316135 51197 110221052
Nasal congestion 837.92 9.74 1211 315839 97071 110175178
Rhinitis allergic 770.26 9.74 535 316515 17387 110254862
Nasal polyps 757.25 9.74 472 316578 12728 110259521
Toxicity to various agents 676.18 9.74 266 316784 480289 109791960
Impaired quality of life 665.28 9.74 607 316443 29410 110242839
Middle insomnia 625.23 9.74 498 316552 20004 110252245
Synovitis 621.65 9.74 42 317008 274050 109998199
Pemphigus 564.54 9.74 10 317040 214560 110057689
Hand deformity 563.66 9.74 13 317037 218493 110053756
Blood immunoglobulin E increased 531.54 9.74 307 316743 7175 110265074
Chronic obstructive pulmonary disease 511.97 9.74 1031 316019 108127 110164122
Respiratory tract infection 500.74 9.74 805 316245 70812 110201437
Acute kidney injury 491.73 9.74 662 316388 634768 109637481
Anti-cyclic citrullinated peptide antibody positive 489.36 9.74 6 317044 181978 110090271
Duodenal ulcer perforation 486.47 9.74 4 317046 177696 110094553
Pericarditis 473.11 9.74 42 317008 219072 110053177
Nightmare 472.19 9.74 570 316480 38293 110233956
Upper-airway cough syndrome 464.02 9.74 376 316674 15481 110256768
Systemic lupus erythematosus 459.99 9.74 86 316964 254252 110017997
Upper respiratory tract infection 454.53 9.74 1098 315952 130230 110142019
Urticaria 442.41 9.74 1949 315101 316908 109955341
Food allergy 439.31 9.74 402 316648 19546 110252703
Helicobacter infection 433.37 9.74 21 317029 181856 110090393
Abnormal behaviour 422.05 9.74 540 316510 38499 110233750
Bronchitis 417.77 9.74 1190 315860 155842 110116407
Glossodynia 416.90 9.74 68 316982 221936 110050313
Pneumonia 409.96 9.74 4072 312978 872642 109399607
Rhinorrhoea 398.59 9.74 898 316152 101768 110170481
Pulmonary function test abnormal 395.21 9.74 220 316830 4780 110267469
Dyspnoea exertional 394.89 9.74 902 316148 103158 110169091
Dermatitis atopic 392.30 9.74 423 316627 25118 110247131
Off label use 386.31 9.74 2621 314429 1497564 108774685
Arthropathy 385.01 9.74 171 316879 287351 109984898
Breath sounds abnormal 381.92 9.74 416 316634 24988 110247261
Loss of personal independence in daily activities 379.90 9.74 1117 315933 148903 110123346
Folliculitis 379.13 9.74 26 317024 167627 110104622
Nasal oedema 375.82 9.74 238 316812 6601 110265648
Influenza 361.48 9.74 1187 315863 167914 110104335
Muscle injury 356.95 9.74 10 317040 140797 110131452
Stomatitis 355.16 9.74 165 316885 270077 110002172
Temperature regulation disorder 347.84 9.74 291 316759 12535 110259714
Gastrooesophageal reflux disease 347.49 9.74 1221 315829 178755 110093494
Impaired healing 340.06 9.74 74 316976 196643 110075606
Rheumatoid factor positive 334.99 9.74 9 317041 131631 110140618
Febrile neutropenia 331.21 9.74 254 316796 316513 109955736
Therapeutic product effect incomplete 327.83 9.74 1391 315659 222414 110049835
Rheumatic fever 325.35 9.74 5 317045 122574 110149675
Sleep terror 323.78 9.74 214 316836 6396 110265853
Asthma-chronic obstructive pulmonary disease overlap syndrome 319.54 9.74 209 316841 6135 110266114
Wound 316.08 9.74 138 316912 234299 110037950
C-reactive protein abnormal 315.43 9.74 13 317037 129682 110142567
Aggression 312.56 9.74 588 316462 58622 110213627
Anaemia 305.72 9.74 699 316351 546387 109725862
Suicidal ideation 305.46 9.74 767 316283 93170 110179079
Drug interaction 304.52 9.74 609 316441 499574 109772675
Confusional state 301.59 9.74 552 316498 468128 109804121
Neutropenia 299.95 9.74 380 316670 374240 109898009
Eosinophilia 297.97 9.74 569 316481 57367 110214882
Asthmatic crisis 294.55 9.74 137 316913 2005 110270244
Sleep apnoea syndrome 294.17 9.74 463 316587 39984 110232265
Liver injury 293.99 9.74 41 317009 150372 110121877
Seasonal allergy 293.06 9.74 321 316729 19401 110252848
Illness 283.12 9.74 686 316364 81485 110190764
Eosinophil count increased 282.56 9.74 325 316725 20733 110251516
C-reactive protein increased 277.23 9.74 139 316911 217780 110054469
General physical health deterioration 272.61 9.74 502 316548 424793 109847456
Pancytopenia 272.27 9.74 130 316920 209483 110062766
Anger 266.31 9.74 300 316750 18707 110253542
Product dose omission issue 262.64 9.74 1700 315350 320082 109952167
Sinusitis 262.41 9.74 1600 315450 295088 109977161
Mood altered 260.44 9.74 314 316736 21061 110251188
Malignant neoplasm progression 259.78 9.74 88 316962 174479 110097770
Sneezing 254.92 9.74 382 316668 31602 110240647
Eye pruritus 253.49 9.74 386 316664 32389 110239860
Facet joint syndrome 252.63 9.74 5 317045 96823 110175426
Polycystic ovaries 241.55 9.74 158 316892 4638 110267611
Anaphylactic reaction 240.29 9.74 798 316252 113502 110158747
Irritable bowel syndrome 235.44 9.74 88 316962 164127 110108122
Intentional product use issue 230.78 9.74 222 316828 247684 110024565
Oropharyngeal pain 230.07 9.74 881 316169 134395 110137854
Blood test abnormal 228.95 9.74 342 316708 28212 110244037
Bronchiectasis 227.91 9.74 390 316660 36103 110236146
Myelosuppression 227.60 9.74 10 317040 94330 110177919
Therapeutic product effect decreased 226.02 9.74 220 316830 244096 110028153
Bronchial secretion retention 225.34 9.74 154 316896 4870 110267379
Injection site pain 223.70 9.74 1057 315993 176865 110095384
Joint range of motion decreased 218.47 9.74 42 317008 121790 110150459
Total lung capacity increased 215.89 9.74 151 316899 4961 110267288
Joint swelling 215.37 9.74 607 316443 442238 109830011
Psoriatic arthropathy 214.36 9.74 151 316899 196610 110075639
Breast cancer stage III 210.92 9.74 3 317047 79114 110193135
Drug abuse 209.84 9.74 124 316926 177287 110094962
Secretion discharge 209.37 9.74 274 316776 19970 110252279
Anxiety 207.20 9.74 1694 315356 343384 109928865
Eczema 207.07 9.74 563 316487 71730 110200519
Disease progression 202.11 9.74 241 316809 243793 110028456
Hypotension 201.29 9.74 796 316254 523053 109749196
Sensitivity to weather change 199.48 9.74 191 316859 9837 110262412
Blister 197.58 9.74 216 316834 227160 110045089
Headache 197.12 9.74 3587 313463 878790 109393459
Alopecia 196.39 9.74 475 316575 364278 109907971
Lip dry 196.22 9.74 27 317023 100056 110172193
Respiratory symptom 196.06 9.74 228 316822 14717 110257532
Sensitisation 195.14 9.74 131 316919 4020 110268229
Throat clearing 194.77 9.74 133 316917 4200 110268049
Infective pulmonary exacerbation of cystic fibrosis 193.19 9.74 225 316825 14546 110257703
Infusion related reaction 192.37 9.74 513 316537 380649 109891600
Completed suicide 186.57 9.74 253 316797 242128 110030121
Maternal exposure during pregnancy 185.36 9.74 277 316773 254606 110017643
Drug intolerance 184.05 9.74 576 316474 405936 109866313
Respiratory tract congestion 182.56 9.74 322 316728 30535 110241714
Reversible airways obstruction 181.41 9.74 104 316946 2395 110269854
Multiple organ dysfunction syndrome 180.88 9.74 105 316945 151605 110120644
Pruritus 180.71 9.74 2499 314551 579061 109693188
Bronchospasm 179.48 9.74 316 316734 29923 110242326
Ear pruritus 179.06 9.74 156 316894 7104 110265145
Chest X-ray abnormal 179.04 9.74 167 316883 8320 110263929
Heart rate increased 178.23 9.74 851 316199 142983 110129266
Sputum increased 175.98 9.74 140 316910 5611 110266638
Contraindicated product administered 174.59 9.74 276 316774 247991 110024258
Vital capacity decreased 174.26 9.74 95 316955 1978 110270271
Treatment failure 174.20 9.74 331 316719 276903 109995346
Pulmonary function test decreased 171.72 9.74 165 316885 8535 110263714
Multiple allergies 169.15 9.74 192 316858 12071 110260178
Dust allergy 168.64 9.74 139 316911 5862 110266387
Death 167.61 9.74 1244 315806 697625 109574624
Immunodeficiency 165.74 9.74 353 316697 38485 110233764
Rash erythematous 161.12 9.74 559 316491 81273 110190976
Depressed mood 159.81 9.74 459 316591 60350 110211899
Rales 159.26 9.74 268 316782 24471 110247778
Thrombocytopenia 158.14 9.74 494 316556 348391 109923858
Sleep disorder due to general medical condition, insomnia type 157.59 9.74 53 316997 105590 110166659
Perfume sensitivity 156.95 9.74 72 316978 1019 110271230
Rhinitis 156.94 9.74 253 316797 22292 110249957
Live birth 156.40 9.74 11 317039 69473 110202776
Bronchial wall thickening 155.07 9.74 103 316947 3104 110269145
Septic shock 153.76 9.74 135 316915 157393 110114856
Inflammation 152.48 9.74 198 316852 193040 110079209
Blood cholesterol increased 152.43 9.74 183 316867 184602 110087647
Vasculitis 151.87 9.74 325 316725 35548 110236701
Lacrimation increased 151.82 9.74 298 316752 30652 110241597
Crying 151.05 9.74 267 316783 25361 110246888
Ejection fraction 145.54 9.74 96 316954 2859 110269390
Liver disorder 144.85 9.74 117 316933 142126 110130123
Abdominal discomfort 142.73 9.74 612 316438 393246 109879003
Diarrhoea 142.42 9.74 2355 314695 1137150 109135099
Exposure via skin contact 142.30 9.74 182 316868 12965 110259284
Restrictive pulmonary disease 139.34 9.74 97 316953 3162 110269087
Gastrointestinal disorder 137.47 9.74 306 316744 241646 110030603
Decreased appetite 137.20 9.74 801 316249 475045 109797204
Renal impairment 136.78 9.74 205 316845 188240 110084009
Mobility decreased 135.93 9.74 299 316751 237123 110035126
Hyponatraemia 134.84 9.74 262 316788 217391 110054858
Respiratory rate increased 133.47 9.74 250 316800 24833 110247416
Bronchial obstruction 132.48 9.74 92 316958 2987 110269262
Allergy to animal 131.81 9.74 77 316973 1839 110270410
Blood pressure systolic increased 131.74 9.74 529 316521 82462 110189787
Forced vital capacity decreased 129.82 9.74 77 316973 1893 110270356
Bronchial hyperreactivity 129.77 9.74 96 316954 3448 110268801
Dysphonia 129.46 9.74 495 316555 75434 110196815
Peripheral venous disease 129.36 9.74 40 317010 84077 110188172
Intentional overdose 128.77 9.74 114 316936 132387 110139862
Irritability 128.67 9.74 364 316686 47445 110224804
Delirium 126.67 9.74 120 316930 134905 110137344
Bronchopulmonary aspergillosis allergic 126.67 9.74 138 316912 8288 110263961
Wound infection 126.48 9.74 59 316991 96406 110175843
Rhabdomyolysis 126.43 9.74 96 316954 120305 110151944
Red blood cell sedimentation rate increased 122.65 9.74 36 317014 78266 110193983
Peak expiratory flow rate decreased 122.52 9.74 53 316997 647 110271602
Coma 122.47 9.74 95 316955 117774 110154475
Sepsis 120.82 9.74 505 316545 326841 109945408
Nasal discharge discolouration 120.12 9.74 88 316962 3113 110269136
Grip strength decreased 119.97 9.74 40 317010 80134 110192115
Musculoskeletal stiffness 119.29 9.74 407 316643 279415 109992834
Platelet count decreased 114.78 9.74 312 316738 230131 110042118
Total lung capacity abnormal 114.08 9.74 99 316951 4484 110267765
Mucosal inflammation 113.94 9.74 67 316983 96074 110176175
Pulmonary vasculitis 113.87 9.74 116 316934 6444 110265805
Ascites 113.83 9.74 62 316988 92746 110179503
Chronic spontaneous urticaria 113.63 9.74 71 316979 1922 110270327
Bone erosion 111.57 9.74 5 317045 46366 110225883
Malaise 111.45 9.74 2615 314435 669204 109603045
Dislocation of vertebra 111.17 9.74 3 317047 43718 110228531
Drug hypersensitivity 109.59 9.74 1870 315180 452220 109820029
Bone marrow failure 107.91 9.74 18 317032 57830 110214419
Prescribed underdose 107.66 9.74 27 317023 65147 110207102
Rhonchi 107.26 9.74 95 316955 4423 110267826
Feeling abnormal 107.17 9.74 885 316165 179826 110092423
Respiration abnormal 106.49 9.74 136 316914 9673 110262576
Spirometry abnormal 104.26 9.74 102 316948 5395 110266854
Hyperkalaemia 104.20 9.74 142 316908 135654 110136595
Sarcoidosis 104.20 9.74 153 316897 12426 110259823
Ill-defined disorder 104.08 9.74 181 316869 156672 110115577
Lung hyperinflation 103.96 9.74 70 316980 2159 110270090
Swelling 103.76 9.74 586 316464 350455 109921794
Blood pressure increased 103.57 9.74 1165 315885 257208 110015041
Inappropriate schedule of product administration 103.50 9.74 964 316086 202673 110069576
Hypokalaemia 103.41 9.74 231 316819 182217 110090032
Haemoptysis 103.18 9.74 442 316608 70912 110201337
Coeliac disease 103.02 9.74 315 316735 42872 110229377
Metabolic acidosis 102.85 9.74 81 316969 99663 110172586
Vocal cord dysfunction 101.15 9.74 51 316999 899 110271350
Cardiac arrest 100.54 9.74 263 316787 196490 110075759
Foetal death 99.55 9.74 171 316879 15874 110256375
Nasal obstruction 99.20 9.74 80 316970 3270 110268979
Neuritis 98.93 9.74 114 316936 7285 110264964
Blepharospasm 98.13 9.74 19 317031 54832 110217417
Musculoskeletal pain 97.89 9.74 239 316811 182784 110089465
Frequent bowel movements 97.79 9.74 41 317009 71349 110200900
Haemoglobin decreased 97.26 9.74 375 316675 248352 110023897
Leukopenia 96.64 9.74 174 316876 148617 110123632
Renal failure 96.25 9.74 330 316720 226244 110046005
Depression 96.07 9.74 1358 315692 315977 109956272
Mite allergy 96.00 9.74 100 316950 5703 110266546
Therapy non-responder 95.99 9.74 191 316859 157116 110115133
Smoke sensitivity 95.93 9.74 45 317005 672 110271577
Erythema 95.07 9.74 1264 315786 290183 109982066
Ejection fraction abnormal 94.85 9.74 79 316971 3381 110268868
Status asthmaticus 94.83 9.74 50 317000 971 110271278
Sinus congestion 94.08 9.74 244 316806 30215 110242034
Autoimmune disorder 93.98 9.74 35 317015 65448 110206801
Sinus disorder 93.82 9.74 255 316795 32473 110239776
Cardiac murmur 92.83 9.74 213 316837 24415 110247834
Abnormal dreams 92.50 9.74 146 316904 12634 110259615
Hypoventilation 92.43 9.74 115 316935 7966 110264283
Mood swings 92.37 9.74 203 316847 22609 110249640
Eye swelling 92.25 9.74 255 316795 32793 110239456
Nasopharyngitis 92.22 9.74 1616 315434 392745 109879504
Tic 92.13 9.74 78 316972 3415 110268834
X-ray abnormal 92.07 9.74 4 317046 38113 110234136
Epilepsy 91.74 9.74 91 316959 100118 110172131
Right atrial hypertrophy 91.32 9.74 43 317007 648 110271601
Injury 91.30 9.74 236 316814 177029 110095220
Night sweats 91.29 9.74 152 316898 133831 110138418
Bradycardia 90.52 9.74 194 316856 155323 110116926
Prolonged expiration 90.28 9.74 56 316994 1496 110270753
Aspirin-exacerbated respiratory disease 89.69 9.74 47 317003 901 110271348
Depressed level of consciousness 89.63 9.74 114 316936 112164 110160085
Emphysema 89.46 9.74 184 316866 19572 110252677
Pulmonary mass 88.91 9.74 272 316778 37029 110235220
Throat irritation 88.73 9.74 346 316704 53206 110219043
Lower limb fracture 88.59 9.74 53 316997 75295 110196954
Onychomadesis 87.91 9.74 13 317037 45650 110226599
Cytomegalovirus infection 87.18 9.74 24 317026 54420 110217829
Poor quality sleep 86.81 9.74 225 316825 27852 110244397
Sciatica 86.80 9.74 82 316968 92317 110179932
Obstruction 86.11 9.74 94 316956 5658 110266591
Incorrect dose administered 85.89 9.74 550 316500 103091 110169158
Adjustment disorder with depressed mood 85.63 9.74 12 317038 43871 110228378
Agranulocytosis 83.75 9.74 36 317014 61724 110210525
Nasal turbinate hypertrophy 83.16 9.74 43 317007 801 110271448
Conjunctivitis allergic 83.10 9.74 101 316949 6830 110265419
Drug-induced liver injury 82.93 9.74 135 316915 119932 110152317
Carpal tunnel syndrome 82.42 9.74 193 316857 22417 110249832
Product dose omission in error 81.71 9.74 197 316853 23315 110248934
Alanine aminotransferase increased 81.24 9.74 263 316787 183510 110088739
Neoplasm progression 80.91 9.74 42 317008 64553 110207696
Colitis ulcerative 80.81 9.74 62 316988 77301 110194948
COVID-19 80.39 9.74 1064 315986 243996 110028253
Scratch 80.10 9.74 138 316912 12841 110259408
Fluid retention 79.72 9.74 503 316547 93804 110178445
Aphonia 79.71 9.74 137 316913 12723 110259526
Cardio-respiratory arrest 79.30 9.74 131 316919 115705 110156544
Neurotoxicity 79.02 9.74 13 317037 42194 110230055
Stress 77.64 9.74 543 316507 104805 110167444
Anosmia 77.48 9.74 133 316917 12339 110259910
Viral infection 77.47 9.74 330 316720 52809 110219440
Cystic fibrosis 77.32 9.74 81 316969 4650 110267599
Hepatic enzyme increased 77.30 9.74 570 316480 320322 109951927
Throat tightness 76.85 9.74 241 316809 33248 110239001
Sedation 76.48 9.74 53 316997 69630 110202619
Dehydration 76.02 9.74 479 316571 279032 109993217
Injection site scab 75.66 9.74 37 317013 609 110271640
Bronchial disorder 75.30 9.74 63 316987 2713 110269536
Gastrointestinal haemorrhage 75.18 9.74 234 316816 165284 110106965
Mycotic allergy 75.05 9.74 89 316961 5865 110266384
C-reactive protein 73.87 9.74 3 317047 30328 110241921
Gait inability 73.78 9.74 177 316873 136199 110136050
Nail disorder 73.56 9.74 37 317013 57898 110214351
Injection site swelling 73.20 9.74 361 316689 61429 110210820
Insomnia 72.62 9.74 1444 315606 359146 109913103
Respiratory syncytial virus test positive 72.28 9.74 48 317002 1446 110270803
Medication error 72.27 9.74 119 316931 105247 110167002
Frustration tolerance decreased 72.03 9.74 106 316944 8625 110263624
Burning sensation 72.02 9.74 390 316660 68822 110203427
Eosinophilic pneumonia chronic 71.01 9.74 34 317016 533 110271716
Injection site erythema 70.92 9.74 488 316562 93688 110178561
Thrombotic microangiopathy 70.60 9.74 3 317047 29146 110243103
White blood cell count decreased 70.44 9.74 378 316672 229012 110043237
Rectal haemorrhage 70.14 9.74 149 316901 119684 110152565
Hepatic cirrhosis 69.61 9.74 55 316995 67571 110204678
Poor quality device used 69.56 9.74 61 316989 2802 110269447
Cardiac failure 69.46 9.74 289 316761 187337 110084912
Injection site pruritus 69.15 9.74 311 316739 50947 110221302
Lupus-like syndrome 69.14 9.74 16 317034 40776 110231473
Sopor 69.00 9.74 11 317039 36535 110235714
Total lung capacity decreased 68.51 9.74 93 316957 7021 110265228
Angioedema 68.12 9.74 500 316550 98000 110174249
Aspartate aminotransferase increased 67.19 9.74 234 316816 159702 110112547
Colitis 67.03 9.74 119 316931 102204 110170045
Serotonin syndrome 66.25 9.74 44 317006 59109 110213140
Sinusitis fungal 66.18 9.74 58 316992 2662 110269587
Educational problem 66.02 9.74 32 317018 516 110271733
Hypercholesterolaemia 65.71 9.74 99 316951 90738 110181511
Oedema 65.69 9.74 904 316146 209072 110063177
Dyspnoea at rest 65.53 9.74 99 316951 8247 110264002
Dry mouth 65.05 9.74 323 316727 199625 110072624
Neuroleptic malignant syndrome 64.87 9.74 10 317040 34049 110238200
Human rhinovirus test positive 64.75 9.74 42 317008 1215 110271034
Muscular weakness 64.41 9.74 432 316618 248036 110024213
Toxic epidermal necrolysis 63.79 9.74 42 317008 56685 110215564
Bronchial neoplasm 63.67 9.74 31 317019 505 110271744
Haematochezia 63.23 9.74 149 316901 115375 110156874
Encephalopathy 62.94 9.74 84 316966 80971 110191278
Swelling face 62.91 9.74 467 316583 91854 110180395
Acute myeloid leukaemia 62.53 9.74 16 317034 38094 110234155
Cardiogenic shock 62.41 9.74 44 317006 57294 110214955
Social avoidant behaviour 62.36 9.74 77 316973 5292 110266957
Hepatic failure 62.25 9.74 63 316987 68676 110203573
Psychomotor hyperactivity 62.18 9.74 162 316888 20115 110252134
Mast cell activation syndrome 61.89 9.74 44 317006 1484 110270765
Acute respiratory distress syndrome 61.73 9.74 38 317012 53160 110219089
Rash maculo-papular 61.72 9.74 73 316977 74149 110198100
Mastocytosis 61.40 9.74 35 317015 797 110271452
Urticaria chronic 61.26 9.74 34 317016 734 110271515
Osteoarthritis 61.15 9.74 292 316758 182331 110089918
Sputum culture positive 60.75 9.74 65 316985 3824 110268425
Haemophagocytic lymphohistiocytosis 60.72 9.74 9 317041 31550 110240699
Palmar-plantar erythrodysaesthesia syndrome 60.45 9.74 21 317029 41004 110231245
Blood creatinine increased 60.32 9.74 294 316756 182595 110089654
Eye irritation 60.26 9.74 222 316828 33230 110239019
Tubulointerstitial nephritis 59.96 9.74 41 317009 54243 110218006
Drug reaction with eosinophilia and systemic symptoms 59.84 9.74 89 316961 82006 110190243
Humidity intolerance 59.64 9.74 29 317021 471 110271778
Taste disorder 59.13 9.74 60 316990 65327 110206922
Salpingo-oophorectomy unilateral 58.76 9.74 34 317016 797 110271452
Idiopathic intracranial hypertension 58.15 9.74 64 316986 3888 110268361
Dysplastic naevus 58.13 9.74 34 317016 814 110271435
Red blood cell sedimentation rate abnormal 57.81 9.74 3 317047 24506 110247743
Right ventricular hypertrophy 57.26 9.74 44 317006 1675 110270574
Sinus polyp 57.10 9.74 31 317019 640 110271609
Hip arthroplasty 56.69 9.74 46 317004 55767 110216482
Neutropenic sepsis 56.39 9.74 10 317040 30736 110241513
Skin plaque 56.35 9.74 117 316933 12528 110259721
Onychomycosis 56.30 9.74 20 317030 38511 110233738
Accidental exposure to product 56.29 9.74 288 316762 49720 110222529
Rheumatoid arthritis 56.17 9.74 568 316482 299045 109973204
Cardiac disorder 55.51 9.74 392 316658 75888 110196361
Drug tolerance decreased 55.00 9.74 7 317043 27533 110244716
Hypoglycaemia 54.97 9.74 161 316889 115943 110156306
Pregnancy 54.52 9.74 40 317010 51027 110221222
Antineutrophil cytoplasmic antibody positive 54.51 9.74 70 316980 5006 110267243
Cytokine release syndrome 54.45 9.74 73 316977 70233 110202016
Pharyngeal swelling 54.41 9.74 112 316938 11920 110260329
Metastases to liver 54.09 9.74 17 317033 35369 110236880
Hyper IgE syndrome 53.92 9.74 30 317020 651 110271598
Melaena 53.65 9.74 71 316979 68686 110203563
Body temperature decreased 53.55 9.74 229 316821 36706 110235543
Chronic sinusitis 53.45 9.74 176 316874 24908 110247341
Body tinea 53.28 9.74 46 317004 2069 110270180
Foot deformity 53.04 9.74 37 317013 48443 110223806
Injection site bruising 52.75 9.74 288 316762 50975 110221274
Hypersensitivity 52.42 9.74 1523 315527 402475 109869774
Nervousness 52.29 9.74 227 316823 36624 110235625
Blood lactic acid increased 52.25 9.74 130 316920 15691 110256558
Rhinitis perennial 51.99 9.74 21 317029 213 110272036
Nephrectomy 51.97 9.74 50 317000 2590 110269659
Drug resistance 51.81 9.74 51 316999 56323 110215926
Metastases to bone 51.81 9.74 13 317037 31359 110240890
Acute myocardial infarction 51.72 9.74 101 316949 83676 110188573
Exostosis 51.71 9.74 34 317016 45922 110226327
Quality of life decreased 51.70 9.74 121 316929 14048 110258201
Victim of child abuse 51.67 9.74 36 317014 1175 110271074
Electrocardiogram QT prolonged 51.65 9.74 151 316899 108809 110163440
Solar lentigo 50.74 9.74 39 317011 1485 110270764
Hypomagnesaemia 50.60 9.74 59 316991 60311 110211938
Finger deformity 50.40 9.74 16 317034 33076 110239173
Dry skin 50.40 9.74 501 316549 107152 110165097
Hypothyroidism 50.38 9.74 370 316680 72529 110199720
Respiratory disorder 50.30 9.74 364 316686 71018 110201231
Photodermatosis 50.25 9.74 34 317016 1057 110271192
Hepatitis 50.21 9.74 115 316935 89939 110182310
Drug level increased 50.14 9.74 38 317012 47681 110224568
Neutrophil count decreased 50.09 9.74 178 316872 120763 110151486
Chest pain 49.97 9.74 1423 315627 374952 109897297
Lung diffusion test decreased 49.81 9.74 40 317010 1625 110270624
Lactic acidosis 49.77 9.74 121 316929 92690 110179559
Blood creatine phosphokinase increased 49.68 9.74 83 316967 72994 110199255
Temperature intolerance 49.68 9.74 118 316932 13832 110258417
Viral test positive 49.36 9.74 31 317019 847 110271402
Interstitial lung disease 48.88 9.74 219 316831 139115 110133134
Disseminated intravascular coagulation 48.59 9.74 29 317021 41257 110230992
Cognitive disorder 48.59 9.74 112 316938 87399 110184850
Ear discomfort 47.71 9.74 102 316948 11147 110261102
Accidental overdose 47.52 9.74 47 317003 51787 110220462
Endometrial ablation 47.18 9.74 31 317019 917 110271332
Personality change 46.94 9.74 100 316950 10902 110261347
International normalised ratio increased 46.63 9.74 113 316937 86659 110185590
Therapeutic response shortened 46.48 9.74 188 316862 29395 110242854
Rheumatoid nodule 46.30 9.74 3 317047 20293 110251956
Injection site urticaria 46.24 9.74 131 316919 17084 110255165
Epidural lipomatosis 46.18 9.74 42 317008 2025 110270224
Upper limb fracture 45.81 9.74 148 316902 20740 110251509
Suffocation feeling 45.76 9.74 42 317008 2049 110270200
Self-injurious ideation 45.21 9.74 59 316991 4287 110267962
Pneumocystis jirovecii pneumonia 44.95 9.74 34 317016 42701 110229548
Fibromyalgia 44.85 9.74 296 316754 170613 110101636
Asthenia 44.79 9.74 1571 315479 687428 109584821
Product use in unapproved indication 44.70 9.74 1635 315415 445742 109826507
Snoring 44.34 9.74 74 316976 6710 110265539
Heart sounds 44.20 9.74 32 317018 1111 110271138
Muscle spasticity 44.02 9.74 24 317026 35891 110236358
Decreased activity 43.69 9.74 97 316953 10877 110261372
Hepatic function abnormal 43.61 9.74 122 316928 89173 110183076
Nausea 43.32 9.74 3006 314044 1232684 109039565
Nasal disorder 43.30 9.74 57 316993 4177 110268072
Hyperbilirubinaemia 43.00 9.74 17 317033 30654 110241595
Nasal inflammation 42.96 9.74 30 317020 983 110271266
Decreased immune responsiveness 42.94 9.74 89 316961 9517 110262732
Transplant rejection 42.92 9.74 9 317041 24558 110247691
Monocyte chemotactic protein-1 increased 42.87 9.74 21 317029 347 110271902
Screaming 42.81 9.74 61 316989 4820 110267429
Pneumococcal infection 42.69 9.74 38 317012 1781 110270468
Injection site rash 42.67 9.74 156 316894 23263 110248986
Nephropathy toxic 42.36 9.74 13 317037 27465 110244784
Back pain 42.36 9.74 1377 315673 369619 109902630
Eosinophilic pneumonia 42.21 9.74 75 316975 7152 110265097
Porphyria acute 42.18 9.74 3 317047 18777 110253472
Oropharyngeal discomfort 41.92 9.74 92 316958 10235 110262014
Pharyngitis streptococcal 41.66 9.74 107 316943 13170 110259079
Altered state of consciousness 41.49 9.74 63 316987 57563 110214686
Road traffic accident 41.26 9.74 163 316887 107235 110165014
Forced expiratory volume abnormal 41.19 9.74 16 317034 145 110272104
Oral allergy syndrome 41.14 9.74 14 317036 83 110272166
Diastolic dysfunction 41.05 9.74 102 316948 12302 110259947
Eye disorder 40.97 9.74 178 316872 28728 110243521
Joint stiffness 40.70 9.74 82 316968 67161 110205088
Type 2 diabetes mellitus 40.67 9.74 319 316731 176913 110095336
Alpha tumour necrosis factor increased 40.62 9.74 21 317029 391 110271858
Circulatory collapse 40.56 9.74 38 317012 42955 110229294
Anuria 40.36 9.74 10 317040 24331 110247918
Drug use disorder 40.27 9.74 3 317047 18071 110254178
Neurological symptom 40.21 9.74 117 316933 15491 110256758
Hepatocellular injury 39.81 9.74 52 316998 50590 110221659
Sleep disorder 39.78 9.74 795 316255 197849 110074400
Clostridium difficile colitis 39.78 9.74 40 317010 43738 110228511
Hypercalcaemia 39.75 9.74 45 317005 46612 110225637
Acute hepatic failure 39.67 9.74 28 317022 36440 110235809
Knee arthroplasty 39.49 9.74 79 316971 64869 110207380
Ischaemic stroke 39.48 9.74 36 317014 41227 110231022
Poisoning 39.40 9.74 17 317033 29088 110243161
Fear 39.35 9.74 151 316899 23042 110249207
Lower respiratory tract congestion 39.24 9.74 58 316992 4738 110267511
Eosinophil count abnormal 39.12 9.74 29 317021 1045 110271204
Haemodynamic instability 38.74 9.74 9 317041 22879 110249370
Terminal insomnia 38.71 9.74 37 317013 1901 110270348
Bronchial haemorrhage 38.71 9.74 32 317018 1355 110270894
Infection susceptibility increased 38.62 9.74 55 316995 4343 110267906
Eosinophil count 38.55 9.74 16 317034 175 110272074
Respiratory tract irritation 38.55 9.74 25 317025 723 110271526
Miosis 38.52 9.74 8 317042 21975 110250274
Lymphopenia 38.49 9.74 35 317015 40135 110232114
Unresponsive to stimuli 38.43 9.74 78 316972 63712 110208537
Hepatic cytolysis 37.91 9.74 62 316988 54991 110217258
Renal tubular necrosis 37.89 9.74 20 317030 30455 110241794
No adverse event 37.70 9.74 350 316700 73489 110198760
Mononeuropathy multiplex 37.63 9.74 26 317024 837 110271412
Respiratory tract inflammation 37.62 9.74 28 317022 1015 110271234
Pulmonary alveolar haemorrhage 37.37 9.74 135 316915 20015 110252234
Pleural effusion 37.09 9.74 328 316722 177381 110094868
Cardiotoxicity 37.06 9.74 3 317047 16878 110255371
Hypomania 37.05 9.74 87 316963 10123 110262126
Child abuse 36.94 9.74 26 317024 863 110271386
Pulmonary congestion 36.73 9.74 181 316869 30785 110241464
Lip swelling 36.64 9.74 260 316790 50407 110221842
Neuropsychiatric symptoms 36.54 9.74 30 317020 1258 110270991
Haematotoxicity 36.27 9.74 8 317042 21074 110251175
Dysphemia 36.21 9.74 51 316999 3986 110268263
Creatinine renal clearance decreased 36.10 9.74 9 317041 21806 110250443
Gamma-glutamyltransferase increased 36.06 9.74 76 316974 61233 110211016
Bacteraemia 35.99 9.74 41 317009 42349 110229900
Negative thoughts 35.90 9.74 33 317017 1613 110270636
Proteinuria 35.87 9.74 37 317013 39981 110232268
Extrapyramidal disorder 35.81 9.74 19 317031 28848 110243401
Affective disorder 35.70 9.74 91 316959 11150 110261099
Increased bronchial secretion 35.60 9.74 50 317000 3898 110268351
Hypereosinophilic syndrome 35.54 9.74 25 317025 829 110271420
Somnambulism 35.53 9.74 65 316985 6340 110265909
Vaccination site pain 35.34 9.74 21 317029 518 110271731
Lymphocyte count decreased 35.34 9.74 69 316981 57174 110215075
Biliary dyskinesia 35.26 9.74 39 317011 2382 110269867
Osteonecrosis of jaw 35.05 9.74 52 316998 47965 110224284
Separation anxiety disorder 35.05 9.74 10 317040 29 110272220
Orthostatic hypotension 35.02 9.74 87 316963 66162 110206087
Attention deficit hyperactivity disorder 34.87 9.74 53 316997 4438 110267811
Metastases to central nervous system 34.81 9.74 11 317039 22806 110249443
FEV1/FVC ratio decreased 34.48 9.74 17 317033 285 110271964
CFTR gene mutation 34.47 9.74 16 317034 233 110272016
Hepatic encephalopathy 34.46 9.74 19 317031 28237 110244012
Blood cholesterol 34.31 9.74 25 317025 877 110271372
Blood potassium decreased 34.21 9.74 269 316781 53845 110218404
Maternal exposure timing unspecified 34.14 9.74 9 317041 21004 110251245
Forced expiratory flow decreased 34.06 9.74 17 317033 293 110271956
Eosinophilic oesophagitis 34.00 9.74 29 317021 1283 110270966
Symptom recurrence 33.83 9.74 54 316996 4718 110267531
Cerebral haemorrhage 33.81 9.74 86 316964 64882 110207367
Eosinophilic bronchitis 33.72 9.74 21 317029 565 110271684
Abdominal pain 33.68 9.74 1168 315882 511821 109760428
Febrile bone marrow aplasia 33.55 9.74 5 317045 17460 110254789
Skin necrosis 33.49 9.74 10 317040 21502 110250747
Cholecystitis chronic 33.44 9.74 80 316970 9420 110262829
Status epilepticus 33.35 9.74 25 317025 31546 110240703
Skin ulcer 33.32 9.74 84 316966 63561 110208688
Pneumonia haemophilus 33.26 9.74 40 317010 2675 110269574
Blood pressure fluctuation 33.11 9.74 107 316943 74717 110197532
Posterior reversible encephalopathy syndrome 33.05 9.74 29 317021 33832 110238417
Respiratory syncytial virus infection 33.01 9.74 104 316946 14380 110257869
Gangrene 33.01 9.74 4 317046 16337 110255912
Sinus bradycardia 32.92 9.74 22 317028 29461 110242788
Second primary malignancy 32.87 9.74 6 317044 18062 110254187
Product label confusion 32.74 9.74 12 317038 22665 110249584
Normal newborn 32.62 9.74 11 317039 21885 110250364
Blood urea increased 32.43 9.74 68 316982 54889 110217360
Emotional distress 32.35 9.74 230 316820 44617 110227632
Hyperhidrosis 32.14 9.74 733 316317 186565 110085684
Hypocalcaemia 32.14 9.74 89 316961 65277 110206972
Subarachnoid haemorrhage 32.05 9.74 23 317027 29679 110242570
Muscle tension dysphonia 32.04 9.74 16 317034 276 110271973
Myocardial infarction 32.03 9.74 374 316676 191709 110080540
Metastases to lung 31.98 9.74 13 317037 23050 110249199
Product substitution issue 31.91 9.74 141 316909 22920 110249329
Wrong technique in product usage process 31.91 9.74 387 316663 86961 110185288
Lipohypertrophy 31.88 9.74 25 317025 981 110271268
Glucose tolerance impaired 31.62 9.74 80 316970 9757 110262492
Cholestasis 31.61 9.74 88 316962 64430 110207819
Liver function test increased 31.16 9.74 139 316911 88409 110183840
Oxygen saturation decreased 31.00 9.74 627 316423 156355 110115894
Diabetic ketoacidosis 30.26 9.74 46 317004 42012 110230237
Blood calcium increased 30.24 9.74 117 316933 17923 110254326
Sinus operation 30.18 9.74 40 317010 2951 110269298
Progressive multifocal leukoencephalopathy 30.12 9.74 17 317033 24939 110247310
Decreased interest 30.04 9.74 52 316998 4856 110267393
Cytomegalovirus viraemia 30.04 9.74 7 317043 17757 110254492
Increased viscosity of bronchial secretion 30.01 9.74 20 317030 606 110271643
Appetite disorder 29.90 9.74 78 316972 9691 110262558
Dyspepsia 29.88 9.74 377 316673 190588 110081661
Ear infection 29.87 9.74 293 316757 62439 110209810
Peripheral swelling 29.83 9.74 906 316144 403128 109869121
Choking sensation 29.81 9.74 49 317001 4387 110267862
Hereditary angioedema 29.59 9.74 64 316986 7050 110265199
Shock haemorrhagic 29.53 9.74 21 317029 27226 110245023
Diffuse large B-cell lymphoma 29.53 9.74 5 317045 15893 110256356
Blood immunoglobulin E decreased 29.50 9.74 14 317036 215 110272034
Stevens-Johnson syndrome 29.42 9.74 56 316994 46845 110225404
Paranasal sinus discomfort 29.41 9.74 60 316990 6345 110265904
Haematuria 29.39 9.74 130 316920 82875 110189374
Torsade de pointes 29.35 9.74 14 317036 22586 110249663
Hysterectomy 29.29 9.74 69 316981 8045 110264204
Hypoalbuminaemia 29.27 9.74 24 317026 28950 110243299
Vision blurred 29.13 9.74 526 316524 128496 110143753
Electrolyte imbalance 29.13 9.74 38 317012 36990 110235259
Skin discomfort 29.04 9.74 33 317017 2077 110270172
Asthma exercise induced 29.04 9.74 14 317036 223 110272026
Poisoning deliberate 28.93 9.74 20 317030 26311 110245938
Influenza like illness 28.60 9.74 383 316667 88029 110184220
Thinking abnormal 28.56 9.74 102 316948 15038 110257211
Blood phosphorus increased 28.52 9.74 6 317044 16334 110255915
Laryngeal stenosis 28.51 9.74 27 317023 1371 110270878
Inhibitory drug interaction 28.46 9.74 51 316999 4896 110267353
Ligament sprain 28.41 9.74 106 316944 15962 110256287
Capillaritis 28.36 9.74 35 317015 2404 110269845
Mononeuropathy 28.36 9.74 16 317034 357 110271892
Pustular psoriasis 28.31 9.74 3 317047 13602 110258647
Nocturnal fear 28.24 9.74 7 317043 9 110272240
Expiratory reserve volume decreased 28.22 9.74 12 317038 140 110272109
Myalgia 28.17 9.74 836 316214 221545 110050704
Cone-rod dystrophy 27.82 9.74 7 317043 10 110272239
Back injury 27.67 9.74 59 316991 47340 110224909
Tongue biting 27.67 9.74 38 317012 2901 110269348
Myositis 27.63 9.74 29 317021 31087 110241162
Dyssomnia 27.56 9.74 9 317041 46 110272203
Multiple-drug resistance 27.33 9.74 3 317047 13232 110259017
Skin swelling 27.33 9.74 67 316983 8013 110264236
Morbid thoughts 27.33 9.74 22 317028 897 110271352
Dysarthria 27.28 9.74 136 316914 83985 110188264
Neuropathy peripheral 27.28 9.74 356 316694 178921 110093328
Prostate cancer 27.24 9.74 41 317009 37600 110234649
Hypertransaminasaemia 27.21 9.74 18 317032 24237 110248012
Seronegative arthritis 27.18 9.74 3 317047 13174 110259075
Platelet count increased 27.13 9.74 148 316902 26186 110246063
Exposure to allergen 26.97 9.74 18 317032 547 110271702
Nocturnal dyspnoea 26.96 9.74 30 317020 1845 110270404
Psoriasis 26.94 9.74 557 316493 139436 110132813
Hyposmia 26.92 9.74 24 317026 1127 110271122
Dysmetropsia 26.86 9.74 11 317039 116 110272133
Respiratory arrest 26.76 9.74 82 316968 58217 110214032
Panic attack 26.75 9.74 158 316892 28782 110243467
Basal cell carcinoma 26.72 9.74 56 316994 45214 110227035
Incorrect route of product administration 26.71 9.74 94 316956 63967 110208282
Surgery 26.53 9.74 206 316844 41077 110231172
Emotional disorder 26.43 9.74 104 316946 16056 110256193
Blood alkaline phosphatase increased 26.40 9.74 109 316941 70826 110201423
Jaundice cholestatic 26.36 9.74 97 316953 14511 110257738
Tympanosclerosis 26.22 9.74 9 317041 55 110272194
Myelodysplastic syndrome 26.01 9.74 42 317008 37442 110234807
Forced expiratory volume increased 25.97 9.74 11 317039 127 110272122
Cytomegalovirus infection reactivation 25.97 9.74 10 317040 18323 110253926
Polyp 25.89 9.74 75 316975 9905 110262344
Lung neoplasm malignant 25.85 9.74 176 316874 33666 110238583
Weight decreased 25.83 9.74 1613 315437 466444 109805805
Mental disorder 25.73 9.74 195 316855 38596 110233653
Cytopenia 25.71 9.74 29 317021 30087 110242162
Homicidal ideation 25.65 9.74 41 317009 3586 110268663
Drug ineffective for unapproved indication 25.54 9.74 181 316869 102657 110169592
Encephalitis 25.51 9.74 11 317039 18828 110253421
Vasomotor rhinitis 25.44 9.74 13 317037 236 110272013
Amniotic fluid index increased 25.43 9.74 10 317040 94 110272155
Dry eye 25.31 9.74 258 316792 55535 110216714
Substance abuse 25.30 9.74 3 317047 12460 110259789
Atrioventricular block first degree 25.29 9.74 5 317045 14220 110258029
Abdominal pain upper 25.24 9.74 785 316265 348326 109923923
Product availability issue 25.19 9.74 64 316986 7826 110264423
Toxic skin eruption 25.16 9.74 25 317025 27490 110244759
Arteriosclerosis coronary artery 25.09 9.74 140 316910 24978 110247271
Radiculopathy 25.07 9.74 12 317038 19324 110252925
Ankle fracture 25.06 9.74 118 316932 19701 110252548
Neurosensory hypoacusis 25.05 9.74 13 317037 244 110272005
Shock 24.86 9.74 75 316975 53513 110218736
Speech disorder 24.80 9.74 278 316772 61291 110210958
Upper gastrointestinal haemorrhage 24.79 9.74 68 316982 50028 110222221
Memory impairment 24.76 9.74 406 316644 196538 110075711
Sinus polyp degeneration 24.71 9.74 9 317041 67 110272182
Panniculitis 24.70 9.74 7 317043 15575 110256674
Ocular hyperaemia 24.68 9.74 195 316855 39091 110233158
Coagulopathy 24.67 9.74 50 317000 40861 110231388
Intervertebral disc degeneration 24.59 9.74 110 316940 17975 110254274
Ventricular fibrillation 24.48 9.74 51 316999 41262 110230987
Infusion site reaction 24.46 9.74 10 317040 17672 110254577
Attention-seeking behaviour 24.45 9.74 10 317040 105 110272144
Obsessive-compulsive disorder 24.44 9.74 60 316990 7181 110265068
Immune reconstitution inflammatory syndrome 24.44 9.74 8 317042 16218 110256031
Electrocardiogram QRS complex prolonged 24.40 9.74 4 317046 13017 110259232
Pneumothorax spontaneous 24.30 9.74 28 317022 1789 110270460
Blood uric acid increased 24.12 9.74 16 317034 21513 110250736
Hemiplegia 24.12 9.74 18 317032 22764 110249485
Underdose 24.07 9.74 97 316953 63457 110208792
Hospitalisation 23.93 9.74 556 316494 141937 110130312
Bronchospasm paradoxical 23.93 9.74 12 317038 209 110272040
Nasal discomfort 23.89 9.74 54 316996 6127 110266122
Endocarditis fibroplastica 23.88 9.74 7 317043 23 110272226
Tumour lysis syndrome 23.83 9.74 32 317018 30769 110241480
Myoclonus 23.83 9.74 36 317014 32962 110239287
Toxic encephalopathy 23.81 9.74 7 317043 15207 110257042
Hiatus hernia 23.79 9.74 148 316902 27458 110244791
Atrioventricular block complete 23.78 9.74 14 317036 20068 110252181
Epstein-Barr virus infection 23.74 9.74 12 317038 18726 110253523
Morose 23.72 9.74 8 317042 46 110272203
Hypoglobulinaemia 23.53 9.74 12 317038 217 110272032
Sinus pain 23.44 9.74 52 316998 5827 110266422
Inappropriate antidiuretic hormone secretion 23.42 9.74 38 317012 33813 110238436
Oral herpes 23.16 9.74 180 316870 35900 110236349
Sputum abnormal 23.14 9.74 24 317026 1362 110270887
Peritonitis 23.13 9.74 36 317014 32571 110239678
Acute generalised exanthematous pustulosis 23.09 9.74 17 317033 21647 110250602
Enterococcal infection 23.01 9.74 15 317035 20351 110251898
Haemodialysis 22.97 9.74 11 317039 17708 110254541
Tenosynovitis 22.87 9.74 9 317041 16274 110255975
Pathogen resistance 22.87 9.74 11 317039 17661 110254588
Blood lactate dehydrogenase increased 22.83 9.74 59 316991 44275 110227974
Pneumonia aspiration 22.69 9.74 138 316912 81095 110191154
Walking aid user 22.68 9.74 23 317027 25052 110247197
Abdominal distension 22.67 9.74 359 316691 174744 110097505
Suicidal behaviour 22.66 9.74 38 317012 3459 110268790
Pneumonia viral 22.63 9.74 77 316973 11080 110261169
Hypoaesthesia 22.60 9.74 707 316343 313516 109958733
Blebitis 22.59 9.74 6 317044 12 110272237
Infusion site swelling 22.59 9.74 71 316979 9806 110262443
NPM1 gene mutation 22.56 9.74 10 317040 130 110272119
Exercise tolerance decreased 22.51 9.74 81 316969 11986 110260263
Spinal operation 22.50 9.74 76 316974 10896 110261353
BK virus infection 22.49 9.74 5 317045 13101 110259148
Ulcer haemorrhage 22.43 9.74 19 317031 22552 110249697
Lung opacity 22.41 9.74 79 316971 11573 110260676
Bacterial disease carrier 22.37 9.74 30 317020 2239 110270010
Hallucination 22.36 9.74 412 316638 101020 110171229
Ligament pain 22.35 9.74 12 317038 242 110272007
Acidosis 22.35 9.74 19 317031 22512 110249737
Cerebral infarction 22.33 9.74 75 316975 51763 110220486
Aplastic anaemia 22.33 9.74 22 317028 24286 110247963
Oesophageal polyp 22.31 9.74 9 317041 91 110272158
Klebsiella infection 22.25 9.74 15 317035 19994 110252255
Ear swelling 22.22 9.74 29 317021 2107 110270142
Hemiparesis 22.17 9.74 59 316991 43844 110228405
Wrist fracture 22.16 9.74 91 316959 14326 110257923
Oliguria 22.10 9.74 13 317037 18644 110253605
Renal disorder 22.06 9.74 228 316822 49251 110222998
Foetal macrosomia 22.05 9.74 9 317041 94 110272155
Enuresis 22.01 9.74 41 317009 4055 110268194
Eye discharge 21.96 9.74 65 316985 8689 110263560
Palpitations 21.94 9.74 605 316445 158607 110113642
Functional residual capacity increased 21.88 9.74 9 317041 96 110272153
Gastroenteritis viral 21.86 9.74 159 316891 31067 110241182
Chronic kidney disease 21.62 9.74 129 316921 76162 110196087
Subdural haematoma 21.60 9.74 45 317005 36409 110235840
Jaundice 21.44 9.74 92 316958 59144 110213105
Brain oedema 21.43 9.74 35 317015 31063 110241186
Sleep talking 21.24 9.74 22 317028 1246 110271003
Polyneuropathy 21.17 9.74 37 317013 31975 110240274
Ileus paralytic 21.13 9.74 4 317046 11733 110260516
Atopy 21.12 9.74 21 317029 1133 110271116
Nasal turbinate abnormality 21.09 9.74 7 317043 38 110272211
Product taste abnormal 21.08 9.74 31 317019 2521 110269728
Retching 21.07 9.74 124 316926 22558 110249691
Product quality issue 21.07 9.74 325 316725 76974 110195275
Ocular discomfort 21.06 9.74 63 316987 8470 110263779
Immune effector cell-associated neurotoxicity syndrome 21.04 9.74 8 317042 14774 110257475
Neuropsychiatric syndrome 20.94 9.74 11 317039 212 110272037
Liver function test abnormal 20.94 9.74 114 316936 68836 110203413
Adrenal suppression 20.80 9.74 25 317025 1671 110270578
Infusion site pruritus 20.77 9.74 45 317005 4963 110267286
Photosensitivity reaction 20.70 9.74 135 316915 25454 110246795
Embolism venous 20.68 9.74 45 317005 4978 110267271
Hypovolaemia 20.63 9.74 19 317031 21655 110250594
Tremor 20.63 9.74 741 316309 201491 110070758
Sedation complication 20.62 9.74 16 317034 19839 110252410
Haemorrhage intracranial 20.54 9.74 32 317018 28937 110243312
Blood parathyroid hormone decreased 20.53 9.74 6 317044 13083 110259166
Onychophagia 20.44 9.74 9 317041 115 110272134
Infusion site erythema 20.40 9.74 78 316972 11881 110260368
Injection site movement impairment 20.18 9.74 6 317044 21 110272228
Bronchiolitis 20.14 9.74 47 317003 5446 110266803
Periorbital swelling 20.07 9.74 47 317003 5458 110266791
Haematemesis 20.07 9.74 94 316956 59014 110213235
Nasal septum deviation 20.06 9.74 28 317022 2170 110270079
Syncope 20.06 9.74 435 316615 202101 110070148
Metastases to lymph nodes 20.00 9.74 9 317041 15023 110257226
Sputum culture 19.98 9.74 12 317038 302 110271947
Cortisol decreased 19.98 9.74 32 317018 2804 110269445
Neurodevelopmental disorder 19.82 9.74 8 317042 81 110272168
Conjunctivitis 19.75 9.74 165 316885 33627 110238622
Condition aggravated 19.72 9.74 1826 315224 733010 109539239
Mechanical urticaria 19.59 9.74 15 317035 568 110271681
Upper airway obstruction 19.59 9.74 25 317025 1777 110270472
Splenomegaly 19.41 9.74 25 317025 24473 110247776
Injection site hypoaesthesia 19.41 9.74 16 317034 675 110271574
Cold urticaria 19.39 9.74 11 317039 248 110272001
Tachycardia 19.33 9.74 498 316552 226147 110046102
Peripheral sensory neuropathy 19.23 9.74 12 317038 16668 110255581
Drug level decreased 19.20 9.74 15 317035 18533 110253716
Benign prostatic hyperplasia 19.13 9.74 103 316947 18131 110254118
Alice in wonderland syndrome 19.12 9.74 7 317043 53 110272196
Injection site discomfort 18.98 9.74 53 316997 6854 110265395
Skin lesion 18.96 9.74 229 316821 51402 110220847
Abdominal pain lower 18.91 9.74 50 317000 37233 110235016
Pleuritic pain 18.90 9.74 94 316956 16046 110256203
Systemic candida 18.83 9.74 3 317047 9971 110262278
Pigment dispersion syndrome 18.82 9.74 6 317044 28 110272221
Fatigue 18.78 9.74 3852 313198 1212106 109060143
Hypothermia 18.70 9.74 29 317021 26273 110245976
Concussion 18.67 9.74 74 316976 11464 110260785
Oesophageal carcinoma 18.60 9.74 5 317045 11519 110260730
Hepatocellular carcinoma 18.59 9.74 3 317047 9877 110262372
Sputum purulent 18.56 9.74 25 317025 1873 110270376
Upper respiratory tract congestion 18.51 9.74 32 317018 2985 110269264
Ventricular tachycardia 18.51 9.74 77 316973 49932 110222317
Lower respiratory tract infection bacterial 18.49 9.74 19 317031 1066 110271183
Drug eruption 18.42 9.74 85 316965 53574 110218675
Injection site vesicles 18.34 9.74 40 317010 4431 110267818
Mucosal discolouration 18.34 9.74 18 317032 956 110271293
Sputum retention 18.27 9.74 21 317029 1338 110270911
Allergic sinusitis 18.25 9.74 24 317026 1757 110270492
Blood calcium decreased 18.23 9.74 48 317002 35797 110236452
Ageusia 17.99 9.74 107 316943 19538 110252711
Kidney transplant rejection 17.90 9.74 6 317044 11981 110260268
Vaginal discharge 17.89 9.74 15 317035 17893 110254356
Pulmonary thrombosis 17.87 9.74 83 316967 13780 110258469
Dermatitis acneiform 17.86 9.74 7 317043 12688 110259561
Seizure 17.81 9.74 490 316560 220695 110051554
Lactose intolerance 17.77 9.74 30 317020 2746 110269503
Sinonasal obstruction 17.63 9.74 12 317038 377 110271872
Blood lactic acid 17.62 9.74 13 317037 465 110271784
Bronchopulmonary aspergillosis 17.58 9.74 37 317013 29826 110242423
Enterocolitis 17.58 9.74 17 317033 18932 110253317
Pulmonary toxicity 17.56 9.74 15 317035 17731 110254518
Duodenal ulcer 17.54 9.74 18 317032 19496 110252753
Discomfort 17.46 9.74 475 316575 214232 110058017
Prostatomegaly 17.46 9.74 38 317012 4204 110268045
Foreign body sensation in eyes 17.45 9.74 33 317017 3301 110268948
Acute sinusitis 17.40 9.74 43 317007 5168 110267081
Pulmonary artery stenosis congenital 17.40 9.74 5 317045 15 110272234
Pharyngeal oedema 17.38 9.74 93 316957 16335 110255914
Arteritis coronary 17.33 9.74 7 317043 71 110272178
Adenovirus infection 17.31 9.74 5 317045 10989 110261260
Obesity 17.27 9.74 225 316825 113126 110159123
Fight in school 17.20 9.74 4 317046 3 110272246
Diaphragmatic disorder 17.18 9.74 24 317026 1862 110270387
Urticaria pressure 17.16 9.74 7 317043 73 110272176
Hyperammonaemia 17.09 9.74 9 317041 13723 110258526
Flushing 17.07 9.74 407 316643 104329 110167920
Middle ear effusion 17.04 9.74 29 317021 2672 110269577
Pulmonary pain 17.01 9.74 48 317002 6245 110266004
Intestinal perforation 16.99 9.74 21 317029 20923 110251326
White coat hypertension 16.95 9.74 20 317030 1311 110270938
Leukoencephalopathy 16.84 9.74 3 317047 9192 110263057
Otorrhoea 16.71 9.74 26 317024 2222 110270027
Pulmonary renal syndrome 16.69 9.74 16 317034 825 110271424
Prothrombin time prolonged 16.58 9.74 15 317035 17246 110255003
Adverse event 16.57 9.74 216 316834 108593 110163656
Hyperkaliuria 16.53 9.74 9 317041 187 110272062
Ileus 16.52 9.74 40 317010 30689 110241560
Joint dislocation 16.48 9.74 47 317003 34143 110238106
Tongue injury 16.44 9.74 14 317036 618 110271631
Arthropod bite 16.44 9.74 63 316987 9608 110262641
Juvenile idiopathic arthritis 16.42 9.74 46 317004 5961 110266288
Blood immunoglobulin G decreased 16.41 9.74 43 317007 5357 110266892
Oral dysaesthesia 16.36 9.74 10 317040 260 110271989
Ataxia 16.34 9.74 39 317011 30069 110242180
Infection 16.34 9.74 860 316190 361340 109910909
Oral pruritus 16.32 9.74 32 317018 3288 110268961
Meningitis eosinophilic 16.30 9.74 5 317045 20 110272229
Cardiac tamponade 16.30 9.74 6 317044 11301 110260948
Cholelithiasis 16.28 9.74 264 316786 63158 110209091
Hot flush 16.26 9.74 273 316777 65763 110206486
Infusion site bruising 16.25 9.74 34 317016 3660 110268589
Increased upper airway secretion 16.25 9.74 42 317008 5190 110267059
Swollen tongue 16.15 9.74 253 316797 60109 110212140
Depressive symptom 16.14 9.74 57 316993 8357 110263892
Delusion 16.13 9.74 27 317023 23728 110248521
Acute pulmonary oedema 16.06 9.74 15 317035 16981 110255268
Mouth swelling 16.03 9.74 52 316998 7302 110264947
Body mass index increased 16.01 9.74 26 317024 2304 110269945
Normochromic normocytic anaemia 15.97 9.74 77 316973 12980 110259269
Proctalgia 15.97 9.74 9 317041 13213 110259036
Cholangitis 15.93 9.74 14 317036 16321 110255928
Therapeutic response unexpected 15.89 9.74 120 316930 23723 110248526
Tearfulness 15.86 9.74 52 316998 7343 110264906
Respiratory gas exchange disorder 15.81 9.74 16 317034 882 110271367
Aortic valve stenosis 15.78 9.74 47 317003 6303 110265946
Bladder cancer 15.78 9.74 21 317029 20271 110251978
Bronchitis chronic 15.70 9.74 40 317010 4900 110267349
Breast conserving surgery 15.67 9.74 16 317034 891 110271358
Ulcer 15.58 9.74 67 316983 43049 110229200
Drug level below therapeutic 15.51 9.74 7 317043 11666 110260583
Sleep paralysis 15.51 9.74 16 317034 902 110271347
Staphylococcal bacteraemia 15.45 9.74 15 317035 16673 110255576
Allergy test positive 15.44 9.74 16 317034 907 110271342
Anal abscess 15.44 9.74 7 317043 11631 110260618
Lip pruritus 15.42 9.74 19 317031 1303 110270946
Facial discomfort 15.34 9.74 11 317039 376 110271873
Interleukin level increased 15.32 9.74 21 317029 1600 110270649
Blood pressure systolic abnormal 15.30 9.74 30 317020 24820 110247429
Overweight 15.27 9.74 47 317003 6417 110265832
Generalised tonic-clonic seizure 15.21 9.74 93 316957 54587 110217662
Nasal pruritus 15.20 9.74 16 317034 924 110271325
Airway remodelling 15.17 9.74 16 317034 926 110271323
Device related infection 15.16 9.74 60 316990 39459 110232790
Injection site eczema 15.14 9.74 7 317043 101 110272148
Vascular device infection 15.10 9.74 15 317035 16497 110255752
Gastric haemorrhage 15.09 9.74 14 317036 15901 110256348
Neurologic neglect syndrome 15.07 9.74 4 317046 9294 110262955
Pyrexia 15.04 9.74 2303 314747 895962 109376287
Haemophilus infection 15.01 9.74 28 317022 2772 110269477
Violence-related symptom 14.93 9.74 16 317034 943 110271306
Endocarditis 14.90 9.74 10 317040 13361 110258888
Premature delivery 14.84 9.74 42 317008 30590 110241659
Duodenitis 14.82 9.74 4 317046 9192 110263057
Muscle rigidity 14.80 9.74 29 317021 24002 110248247
Chimerism 14.78 9.74 10 317040 311 110271938
Gluten sensitivity 14.66 9.74 12 317038 501 110271748
Hypohidrosis 14.64 9.74 10 317040 316 110271933
Skin burning sensation 14.64 9.74 110 316940 21715 110250534
Platelet adhesiveness decreased 14.57 9.74 3 317047 0 110272249
Sleep study abnormal 14.57 9.74 3 317047 0 110272249
Aphasia 14.57 9.74 104 316946 58893 110213356
Renal oncocytoma 14.56 9.74 9 317041 239 110272010
Glomerular filtration rate decreased 14.56 9.74 39 317011 28917 110243332
Obsessive-compulsive symptom 14.55 9.74 10 317040 319 110271930
Hypercapnia 14.52 9.74 67 316983 11092 110261157
Animal scratch 14.52 9.74 22 317028 1837 110270412
Ehlers-Danlos syndrome 14.50 9.74 10 317040 321 110271928
Overlap syndrome 14.49 9.74 4 317046 9055 110263194
Peak expiratory flow rate increased 14.45 9.74 4 317046 10 110272239
Uveitis 14.44 9.74 25 317025 21685 110250564
Sinus headache 14.39 9.74 44 317006 5988 110266261
Postural orthostatic tachycardia syndrome 14.32 9.74 22 317028 1860 110270389
Urticaria thermal 14.30 9.74 12 317038 519 110271730
Eye paraesthesia 14.28 9.74 8 317042 176 110272073
Faecaloma 14.27 9.74 13 317037 14895 110257354
Haematocrit decreased 14.25 9.74 121 316929 65996 110206253
Body temperature abnormal 14.13 9.74 29 317021 3080 110269169
Enterobiasis 14.11 9.74 6 317044 70 110272179
Laryngitis fungal 14.04 9.74 8 317042 182 110272067
Laryngospasm 14.01 9.74 37 317013 4631 110267618
Chronic rhinosinusitis with nasal polyps 14.01 9.74 7 317043 121 110272128
Neutropenic colitis 14.00 9.74 3 317047 8062 110264187
Lymphostasis 13.99 9.74 5 317045 35 110272214
Stiff person syndrome 13.95 9.74 13 317037 647 110271602
Lung hernia 13.89 9.74 6 317044 73 110272176
Pharyngitis 13.85 9.74 121 316929 24977 110247272
Pulmonary oedema 13.83 9.74 204 316846 100455 110171794
Functional residual capacity decreased 13.82 9.74 6 317044 74 110272175
Panic reaction 13.81 9.74 40 317010 5282 110266967
Aspiration 13.76 9.74 141 316909 30392 110241857
Restless legs syndrome 13.73 9.74 119 316931 24507 110247742
Enteritis 13.73 9.74 21 317029 19135 110253114
Hyperreflexia 13.73 9.74 5 317045 9480 110262769
Immune-mediated enterocolitis 13.71 9.74 6 317044 10179 110262070
Breast neoplasm 13.64 9.74 16 317034 1042 110271207
Hypovolaemic shock 13.62 9.74 13 317037 14570 110257679
Left-to-right cardiac shunt 13.62 9.74 8 317042 193 110272056
Dialysis 13.60 9.74 22 317028 19597 110252652
Pancreatitis acute 13.58 9.74 109 316941 60165 110212084
School refusal 13.53 9.74 5 317045 39 110272210
Granulocytopenia 13.52 9.74 10 317040 12705 110259544
Lower gastrointestinal haemorrhage 13.51 9.74 20 317030 18466 110253783
Intervertebral disc protrusion 13.49 9.74 130 316920 27568 110244681
Immunisation reaction 13.49 9.74 14 317036 795 110271454
Urosepsis 13.48 9.74 44 317006 30631 110241618
Bronchiolitis obliterans syndrome 13.45 9.74 13 317037 677 110271572
Self esteem decreased 13.41 9.74 16 317034 1061 110271188
Hallucination, auditory 13.41 9.74 125 316925 26272 110245977
Inflammatory marker increased 13.40 9.74 13 317037 14456 110257793
Kidney infection 13.40 9.74 122 316928 25477 110246772
Blood albumin decreased 13.34 9.74 38 317012 27614 110244635
Precancerous condition 13.33 9.74 12 317038 571 110271678
Product use issue 13.32 9.74 744 316306 310951 109961298
Hypernatraemia 13.32 9.74 19 317031 17814 110254435
Hypervolaemia 13.30 9.74 85 316965 49375 110222874
Formication 13.28 9.74 41 317009 5607 110266642
Hepatitis C 13.23 9.74 10 317040 12563 110259686
Pneumatosis intestinalis 13.21 9.74 4 317046 8525 110263724
Bipolar disorder 13.17 9.74 56 316994 8951 110263298
Osteomyelitis 13.15 9.74 57 316993 36543 110235706
Therapy partial responder 13.14 9.74 58 316992 37003 110235246
Gastric ulcer 13.14 9.74 64 316986 39763 110232486
Hepatic lesion 13.13 9.74 4 317046 8489 110263760
Graft versus host disease 13.12 9.74 21 317029 18785 110253464
Cystic fibrosis respiratory infection suppression 13.06 9.74 11 317039 478 110271771
Nasal dryness 13.03 9.74 41 317009 5665 110266584
Gastroenteritis eosinophilic 13.01 9.74 10 317040 381 110271868
Systemic inflammatory response syndrome 12.94 9.74 11 317039 13032 110259217
Nasal mucosal disorder 12.93 9.74 21 317029 1862 110270387
Cephalo-pelvic disproportion 12.92 9.74 7 317043 144 110272105
Musculoskeletal chest pain 12.90 9.74 133 316917 28714 110243535
Breast cancer 12.89 9.74 168 316882 38374 110233875
Exposure to fungus 12.89 9.74 8 317042 214 110272035
Urticarial vasculitis 12.86 9.74 15 317035 971 110271278
Therapeutic response decreased 12.82 9.74 365 316685 96134 110176115
Dermatitis contact 12.78 9.74 76 316974 13877 110258372
Bacterial sepsis 12.73 9.74 7 317043 10419 110261830
Adenotonsillectomy 12.71 9.74 6 317044 91 110272158
Mastication disorder 12.68 9.74 30 317020 3508 110268741
Stress cardiomyopathy 12.66 9.74 16 317034 15790 110256459
Allergic respiratory disease 12.66 9.74 7 317043 150 110272099
Adverse reaction 12.62 9.74 43 317007 29551 110242698
Crepitations 12.61 9.74 63 316987 10772 110261477
Blood immunoglobulin E 12.53 9.74 5 317045 49 110272200
Skin fissures 12.52 9.74 116 316934 24342 110247907
Initial insomnia 12.52 9.74 61 316989 10328 110261921
Allergy to fermented products 12.50 9.74 3 317047 3 110272246
Pigmentary glaucoma 12.50 9.74 3 317047 3 110272246
Gout 12.49 9.74 160 316890 36406 110235843
Renal function test abnormal 12.47 9.74 5 317045 8941 110263308
Obsessive thoughts 12.46 9.74 17 317033 1290 110270959
Autism spectrum disorder 12.40 9.74 21 317029 1927 110270322
Choking 12.40 9.74 80 316970 15030 110257219
Clostridium test positive 12.34 9.74 8 317042 10885 110261364
Cronobacter infection 12.32 9.74 4 317046 20 110272229
Breast cancer stage I 12.32 9.74 3 317047 7384 110264865
Hyperlipidaemia 12.30 9.74 157 316893 35691 110236558
SARS-CoV-2 test positive 12.30 9.74 87 316963 16848 110255401
Airway peak pressure increased 12.29 9.74 12 317038 633 110271616
Cold agglutinins positive 12.27 9.74 5 317045 52 110272197
Urine output decreased 12.23 9.74 24 317026 19852 110252397
Steroid diabetes 12.23 9.74 38 317012 5216 110267033
Mandibular mass 12.22 9.74 8 317042 235 110272014
Skin atrophy 12.19 9.74 44 317006 6520 110265729
Dizziness exertional 12.19 9.74 13 317037 762 110271487
PCO2 increased 12.17 9.74 21 317029 1956 110270293
Motor dysfunction 12.17 9.74 33 317017 24373 110247876
Decubitus ulcer 12.13 9.74 21 317029 18215 110254034
Overdose 12.13 9.74 547 316503 233247 110039002
Bradykinesia 12.11 9.74 8 317042 10780 110261469
Respiratory fume inhalation disorder 12.11 9.74 8 317042 239 110272010
Haemorrhagic stroke 12.08 9.74 13 317037 13776 110258473
Neutrophil toxic granulation present 12.08 9.74 8 317042 240 110272009
Malnutrition 12.07 9.74 39 317011 27240 110245009
Drug tolerance 12.07 9.74 18 317032 16567 110255682
Drug withdrawal syndrome 12.06 9.74 62 316988 37992 110234257
Dyskinesia oesophageal 12.02 9.74 5 317045 55 110272194
Acne 12.02 9.74 148 316902 33372 110238877
Cough variant asthma 12.01 9.74 4 317046 22 110272227
Product administration interrupted 11.99 9.74 64 316986 11228 110261021
Psychological trauma 11.95 9.74 19 317031 1654 110270595
Measles 11.89 9.74 12 317038 659 110271590
Alopecia areata 11.89 9.74 22 317028 2165 110270084
Uterine cyst 11.89 9.74 9 317041 335 110271914
Behaviour disorder 11.88 9.74 57 316993 9590 110262659
Urinary retention 11.87 9.74 135 316915 69548 110202701
Laziness 11.86 9.74 14 317036 918 110271331
Injection site oedema 11.82 9.74 20 317030 1834 110270415
Pancreatitis relapsing 11.78 9.74 18 317032 1514 110270735
Serum ferritin increased 11.74 9.74 10 317040 11837 110260412
Peritoneal perforation 11.73 9.74 7 317043 174 110272075
Multiple sclerosis relapse 11.72 9.74 90 316960 50150 110222099
Acute coronary syndrome 11.71 9.74 31 317019 23081 110249168
Appendicitis 11.71 9.74 42 317008 28422 110243827
Peak expiratory flow rate abnormal 11.69 9.74 6 317044 110 110272139
Small intestinal obstruction 11.68 9.74 50 317000 32163 110240086
Oesophagogastroduodenoscopy 11.68 9.74 8 317042 254 110271995
Head banging 11.64 9.74 11 317039 557 110271692
Hepatic cancer 11.57 9.74 9 317041 11147 110261102
Carboxyhaemoglobin increased 11.56 9.74 5 317045 61 110272188
Diabetes mellitus inadequate control 11.55 9.74 45 317005 29730 110242519
Administration site reaction 11.52 9.74 7 317043 180 110272069
Penile erythema 11.52 9.74 7 317043 180 110272069
Red blood cell count decreased 11.51 9.74 127 316923 65796 110206453
Bradyphrenia 11.50 9.74 10 317040 11718 110260531
Immunosuppressant drug level increased 11.49 9.74 10 317040 11714 110260535
Disease prodromal stage 11.49 9.74 5 317045 62 110272187
Vocal cord disorder 11.45 9.74 19 317031 1714 110270535
Febrile convulsion 11.44 9.74 15 317035 1095 110271154
Paronychia 11.42 9.74 9 317041 11072 110261177
Cockroach allergy 11.40 9.74 6 317044 116 110272133
Paranoia 11.39 9.74 106 316944 22268 110249981
Pneumonia mycoplasmal 11.39 9.74 19 317031 1722 110270527
Steroid dependence 11.38 9.74 5 317045 8464 110263785
Foreign body in reproductive tract 11.36 9.74 14 317036 960 110271289
Personality disorder 11.36 9.74 12 317038 12825 110259424
Oral mucosal blistering 11.35 9.74 49 317001 7885 110264364
Dystonia 11.35 9.74 37 317013 25768 110246481
Ankylosing spondylitis 11.30 9.74 17 317033 15595 110256654
Oropharyngeal cobble stone mucosa 11.29 9.74 3 317047 6 110272243
Blood potassium increased 11.22 9.74 53 316997 33196 110239053
Oral mucosal erythema 11.21 9.74 22 317028 2262 110269987
Atrial fibrillation 11.17 9.74 541 316509 229101 110043148
Near drowning 11.14 9.74 5 317045 67 110272182
Hepatotoxicity 11.13 9.74 122 316928 63278 110208971
Hilar lymphadenopathy 11.09 9.74 22 317028 2280 110269969
Autophobia 11.07 9.74 4 317046 29 110272220
Swelling of eyelid 11.03 9.74 43 317007 6610 110265639
Escherichia sepsis 11.02 9.74 8 317042 10264 110261985
Macular degeneration 11.02 9.74 29 317021 21630 110250619
Hepatitis cholestatic 10.99 9.74 21 317029 17545 110254704
Night blindness 10.99 9.74 11 317039 598 110271651
Burns third degree 10.98 9.74 10 317040 483 110271766
Dermatitis bullous 10.93 9.74 21 317029 17508 110254741
Intercepted product preparation error 10.93 9.74 3 317047 6817 110265432
Tongue discolouration 10.91 9.74 31 317019 4050 110268199
Mental status changes 10.91 9.74 153 316897 75969 110196280
Gallbladder disorder 10.89 9.74 100 316950 20929 110251320
Heparin-induced thrombocytopenia 10.89 9.74 10 317040 11414 110260835
Arthritis bacterial 10.88 9.74 9 317041 10811 110261438
Idiopathic urticaria 10.87 9.74 8 317042 285 110271964
Bone density decreased 10.84 9.74 81 316969 15961 110256288
Pathergy reaction 10.82 9.74 5 317045 72 110272177
Allergy to plants 10.80 9.74 13 317037 870 110271379
Proctitis 10.80 9.74 20 317030 16907 110255342
Viral myelitis 10.79 9.74 6 317044 130 110272119
Lower respiratory tract infection 10.79 9.74 823 316227 242283 110029966
Disease recurrence 10.77 9.74 239 316811 60545 110211704
Abortion 10.75 9.74 18 317032 1636 110270613
Atrioventricular block 10.72 9.74 20 317030 16857 110255392
Concomitant disease aggravated 10.71 9.74 82 316968 16282 110255967
Diverticulum oesophageal 10.69 9.74 7 317043 206 110272043
Skin exfoliation 10.68 9.74 328 316722 87323 110184926
Intentional dose omission 10.66 9.74 96 316954 19984 110252265
Bronchitis bacterial 10.65 9.74 19 317031 1817 110270432
Increased viscosity of upper respiratory secretion 10.65 9.74 11 317039 621 110271628
Ventricular arrhythmia 10.64 9.74 8 317042 10079 110262170
Ketoacidosis 10.64 9.74 8 317042 10079 110262170
Failure to thrive 10.60 9.74 14 317036 13560 110258689
Venoocclusive liver disease 10.59 9.74 17 317033 15190 110257059
Injection site paraesthesia 10.55 9.74 12 317038 756 110271493
Amnesia 10.54 9.74 226 316824 105182 110167067
Suicide attempt 10.54 9.74 221 316829 103173 110169076
Papule 10.47 9.74 57 316993 10076 110262173
Small airways disease 10.46 9.74 5 317045 78 110272171
Hyperventilation 10.40 9.74 52 316998 8895 110263354
Bronchitis viral 10.39 9.74 16 317034 1355 110270894
Catarrh 10.39 9.74 4 317046 7331 110264918
Bundle branch block left 10.37 9.74 13 317037 12875 110259374
Mycobacterial infection 10.33 9.74 32 317018 4385 110267864
Diabetes insipidus 10.33 9.74 3 317047 6567 110265682
Hypoxia 10.28 9.74 462 316588 129053 110143196
Diverticulum 10.27 9.74 78 316972 15448 110256801
Neurogenic shock 10.22 9.74 13 317037 921 110271328
Eosinophilic otitis media 10.20 9.74 3 317047 10 110272239
Immune system disorder 10.18 9.74 70 316980 13431 110258818
Infusion site mass 10.18 9.74 18 317032 1710 110270539
Head deformity 10.13 9.74 5 317045 84 110272165
Forearm fracture 10.13 9.74 11 317039 658 110271591
Hyperplastic cholecystopathy 10.11 9.74 7 317043 226 110272023
Hypersomnia 10.10 9.74 124 316926 27937 110244312
Joint injury 10.09 9.74 166 316884 39828 110232421
Systemic infection 10.09 9.74 8 317042 9811 110262438
Arthralgia 10.08 9.74 2027 315023 777605 109494644
Gastric cancer 10.07 9.74 10 317040 10998 110261251
Lip discolouration 10.06 9.74 12 317038 796 110271453
Benign renal neoplasm 10.04 9.74 4 317046 39 110272210
Hepatitis B e antigen positive 10.04 9.74 4 317046 39 110272210
Red blood cell count increased 10.03 9.74 34 317016 4884 110267365
Product container issue 10.01 9.74 17 317033 1563 110270686
Hypertensive crisis 10.00 9.74 36 317014 24336 110247913
Upper airway resistance syndrome 9.98 9.74 3 317047 11 110272238
Wheelchair user 9.97 9.74 5 317045 7837 110264412
Injection site discolouration 9.95 9.74 52 316998 9051 110263198
Rash macular 9.92 9.74 161 316889 38525 110233724
Colorectal cancer 9.91 9.74 7 317043 9107 110263142
Tissue injury 9.85 9.74 6 317044 155 110272094
Fistula 9.83 9.74 18 317032 15281 110256968
Alcohol intolerance 9.82 9.74 9 317041 438 110271811
Gastrointestinal tract mucosal pigmentation 9.82 9.74 15 317035 1262 110270987
Graft versus host disease in lung 9.81 9.74 15 317035 1263 110270986
Pulmonary arterial hypertension 9.80 9.74 54 316996 32514 110239735
Hyperaesthesia teeth 9.78 9.74 21 317029 2301 110269948
Magnetic resonance imaging heart 9.78 9.74 3 317047 12 110272237
Perennial allergy 9.78 9.74 3 317047 12 110272237
Gingival bleeding 9.76 9.74 27 317023 19812 110252437

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R03DC03 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Leukotriene receptor antagonists
ATC R03DC53 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
Leukotriene receptor antagonists
FDA MoA N0000000083 Leukotriene Receptor Antagonists
MeSH PA D006727 Hormone Antagonists
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D019141 Respiratory System Agents
MeSH PA D020024 Leukotriene Antagonists
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
MeSH PA D065694 Cytochrome P-450 CYP1A2 Inducers
FDA EPC N0000175777 Leukotriene Receptor Antagonist
CHEBI has role CHEBI:50857 anti-allergic agent
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:49159 leukotriene antagonist
CHEBI has role CHEBI:49167 anti-asthmatic drug
CHEBI has role CHEBI:51177 antitussive
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:75835 anti-anaemic agent

Related Drugs by ATC class:

R03DC Leukotriene receptor antagonists 3 drugs
ibudilastpranlukastzafirlukast

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Allergic rhinitis indication 61582004
Non-allergic asthma indication 266361008 DOID:9360
Allergic asthma indication 389145006 DOID:9415
Asthma management indication 406162001
Exercise-Induced Bronchospasm Prevention indication
Suicidal thoughts contraindication 6471006
Hallucinations contraindication 7011001
Mood swings contraindication 18963009
Feeling agitated contraindication 24199005
Depressive disorder contraindication 35489007
Anxiety contraindication 48694002
Vasculitis of the skin contraindication 53312001
Dream disorder contraindication 85418005
Eosinophil count raised contraindication 386789004
Tremors contraindication
Nervousness contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.28 acidic
pKa2 4.98 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Cysteinyl leukotriene receptor 1 GPCR ANTAGONIST Ki 9.30 CHEMBL CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 5.83 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.57 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 5.40 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 5.58 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 5.71 DRUG MATRIX
Muscarinic acetylcholine receptor M3 GPCR Ki 5.85 DRUG MATRIX
Beta-3 adrenergic receptor GPCR Ki 5.50 DRUG MATRIX
Alpha-2C adrenergic receptor GPCR Ki 6.12 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.69 DRUG MATRIX
Adenosine receptor A3 GPCR Ki 6.61 DRUG MATRIX
Cytochrome P450 2C8 Enzyme Ki 5.96 WOMBAT-PK
Delta-type opioid receptor GPCR Ki 5.77 DRUG MATRIX
Arachidonate 5-lipoxygenase Enzyme Ki 4.33 WOMBAT-PK
Epidermal growth factor receptor Kinase IC50 5.50 DRUG MATRIX
Tyrosine-protein kinase Fyn Kinase IC50 5.33 DRUG MATRIX
Thromboxane-A synthase Enzyme IC50 5.82 DRUG MATRIX
Cysteinyl leukotriene receptor 2 GPCR Ki 5.30 PDSP
Mitogen-activated protein kinase 14 Kinase IC50 6.07 DRUG MATRIX
Substance-K receptor GPCR Ki 5.90 DRUG MATRIX
Uracil nucleotide/cysteinyl leukotriene receptor GPCR Ki 5.18 CHEMBL
Beta-2 adrenergic receptor GPCR Ki 5.62 DRUG MATRIX
Cysteinyl leukotriene receptor 1 GPCR Ki 9.30 CHEMBL
Uracil nucleotide/cysteinyl leukotriene receptor GPCR ANTAGONIST IC50 7.21 IUPHAR

External reference:

IDSource
4024117 VUID
N0000022122 NUI
D00529 KEGG_DRUG
151767-02-1 SECONDARY_CAS_RN
4021110 VANDF
4024117 VANDF
C0298130 UMLSCUI
CHEBI:50730 CHEBI
MTK PDB_CHEM_ID
CHEMBL787 ChEMBL_ID
CHEMBL1200681 ChEMBL_ID
DB00471 DRUGBANK_ID
C093875 MESH_SUPPLEMENTAL_RECORD_UI
3340 IUPHAR_LIGAND_ID
7388 INN_ID
MHM278SD3E UNII
5281040 PUBCHEM_CID
115713 RXNORM
11578 MMSL
189710 MMSL
5134 MMSL
d04289 MMSL
007256 NDDF
007257 NDDF
108620002 SNOMEDCT_US
320883008 SNOMEDCT_US
373728005 SNOMEDCT_US
MHM278SD3E INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
MONTELUKAST HUMAN PRESCRIPTION DRUG LABEL 1 0143-9649 TABLET, FILM COATED 10 mg ORAL ANDA 25 sections
MONTELUKAST HUMAN PRESCRIPTION DRUG LABEL 1 0143-9650 TABLET, CHEWABLE 5 mg ORAL ANDA 25 sections
MONTELUKAST HUMAN PRESCRIPTION DRUG LABEL 1 0143-9651 TABLET, CHEWABLE 4 mg ORAL ANDA 25 sections
Montelukast HUMAN PRESCRIPTION DRUG LABEL 1 0781-5560 TABLET, FILM COATED 10 mg ORAL ANDA 27 sections
Montelukast Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0904-6808 TABLET, FILM COATED 10 mg ORAL ANDA 28 sections
Montelukast Sodium HUMAN PRESCRIPTION DRUG LABEL 1 13668-079 TABLET, CHEWABLE 4 mg ORAL ANDA 28 sections
Montelukast Sodium HUMAN PRESCRIPTION DRUG LABEL 1 13668-080 TABLET, CHEWABLE 5 mg ORAL ANDA 28 sections
Montelukast Sodium HUMAN PRESCRIPTION DRUG LABEL 1 13668-081 TABLET 10 mg ORAL ANDA 28 sections
Montelukast Sodium HUMAN PRESCRIPTION DRUG LABEL 1 13668-531 GRANULE 4 mg ORAL ANDA 28 sections
MONTELUKAST SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 16571-100 TABLET 10 mg ORAL ANDA 19 sections
Montelukast Sodium HUMAN PRESCRIPTION DRUG LABEL 1 16729-119 TABLET, FILM COATED 10 mg ORAL ANDA 28 sections
SINGULAIR HUMAN PRESCRIPTION DRUG LABEL 1 21695-221 TABLET, FILM COATED 10 mg ORAL NDA 28 sections
SINGULAIR HUMAN PRESCRIPTION DRUG LABEL 1 21695-565 TABLET, CHEWABLE 5 mg ORAL NDA 28 sections
MONTELUKAST SODIUM Human Prescription Drug Label 1 27241-015 GRANULE 4 mg ORAL ANDA 28 sections
MONTELUKAST SODIUM Human Prescription Drug Label 1 27241-016 TABLET, CHEWABLE 4 mg ORAL ANDA 28 sections
MONTELUKAST SODIUM Human Prescription Drug Label 1 27241-017 TABLET, CHEWABLE 5 mg ORAL ANDA 28 sections
MONTELUKAST SODIUM Human Prescription Drug Label 1 27241-018 TABLET, COATED 10 mg ORAL ANDA 28 sections
montelukast sodium HUMAN PRESCRIPTION DRUG LABEL 1 29300-220 TABLET, FILM COATED 10 mg ORAL ANDA 26 sections
montelukast sodium HUMAN PRESCRIPTION DRUG LABEL 1 29300-221 TABLET, CHEWABLE 4 mg ORAL ANDA 26 sections
montelukast sodium HUMAN PRESCRIPTION DRUG LABEL 1 29300-222 TABLET, CHEWABLE 5 mg ORAL ANDA 26 sections
MONTELUKAST SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 31722-726 TABLET, FILM COATED 10 mg ORAL ANDA 28 sections
montelukast sodium HUMAN PRESCRIPTION DRUG LABEL 1 31722-727 TABLET, CHEWABLE 4 mg ORAL ANDA 28 sections
montelukast sodium HUMAN PRESCRIPTION DRUG LABEL 1 31722-728 TABLET, CHEWABLE 5 mg ORAL ANDA 28 sections
montelukast sodium HUMAN PRESCRIPTION DRUG LABEL 1 33261-969 TABLET, FILM COATED 10 mg ORAL ANDA 29 sections
Montelukast Human Prescription Drug Label 1 33342-102 TABLET 10 mg ORAL ANDA 28 sections
Montelukast sodium Human Prescription Drug Label 1 33342-110 TABLET, CHEWABLE 4 mg ORAL ANDA 28 sections
Montelukast sodium Human Prescription Drug Label 1 33342-111 TABLET, CHEWABLE 5 mg ORAL ANDA 28 sections
Montelukast Sodium HUMAN PRESCRIPTION DRUG LABEL 1 42254-263 TABLET, FILM COATED 10 mg ORAL ANDA 31 sections
Montelukast Sodium HUMAN PRESCRIPTION DRUG LABEL 1 42291-621 TABLET, FILM COATED 10 mg ORAL ANDA 29 sections
Montelukast Sodium HUMAN PRESCRIPTION DRUG LABEL 1 42291-621 TABLET, FILM COATED 10 mg ORAL ANDA 29 sections