Stem definition | Drug id | CAS RN |
---|---|---|
calcium channel blockers, nifedipine derivatives | 183 | 88150-42-9 |
Dose | Unit | Route |
---|---|---|
5 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 10 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.35 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 74 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 17 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 7 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.01 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 34 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
July 31, 1992 | FDA | PFIZER |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Rheumatoid arthritis | 847.28 | 9.82 | 659 | 395717 | 313872 | 52638818 |
Drug ineffective | 814.17 | 9.82 | 3229 | 393147 | 814016 | 52138674 |
Maternal exposure during pregnancy | 650.26 | 9.82 | 176 | 396200 | 155463 | 52797227 |
Pemphigus | 636.56 | 9.82 | 33 | 396343 | 103998 | 52848692 |
Completed suicide | 569.20 | 9.82 | 2282 | 394094 | 135919 | 52816771 |
Systemic lupus erythematosus | 552.52 | 9.82 | 127 | 396249 | 125287 | 52827403 |
Contraindicated product administered | 546.85 | 9.82 | 164 | 396212 | 135465 | 52817225 |
Hypotension | 495.93 | 9.82 | 3408 | 392968 | 250668 | 52702022 |
Treatment failure | 484.70 | 9.82 | 174 | 396202 | 128229 | 52824461 |
Glossodynia | 457.08 | 9.82 | 94 | 396282 | 100197 | 52852493 |
Hand deformity | 454.12 | 9.82 | 50 | 396326 | 84799 | 52867891 |
Synovitis | 441.21 | 9.82 | 127 | 396249 | 107766 | 52844924 |
Hyponatraemia | 424.50 | 9.82 | 1765 | 394611 | 106842 | 52845848 |
Anti-cyclic citrullinated peptide antibody positive | 407.15 | 9.82 | 3 | 396373 | 57169 | 52895521 |
Drug intolerance | 405.29 | 9.82 | 561 | 395815 | 204932 | 52747758 |
Acute kidney injury | 404.67 | 9.82 | 3246 | 393130 | 250622 | 52702068 |
Blood pressure inadequately controlled | 398.44 | 9.82 | 314 | 396062 | 4597 | 52948093 |
Infusion related reaction | 396.59 | 9.82 | 345 | 396031 | 155612 | 52797078 |
Shock | 392.01 | 9.82 | 654 | 395722 | 22485 | 52930205 |
Off label use | 377.19 | 9.82 | 2018 | 394358 | 470194 | 52482496 |
Hypertension | 375.97 | 9.82 | 2913 | 393463 | 222518 | 52730172 |
Blood pressure increased | 375.45 | 9.82 | 2045 | 394331 | 138434 | 52814256 |
Therapeutic product effect decreased | 370.92 | 9.82 | 238 | 396138 | 125417 | 52827273 |
Gingival hypertrophy | 364.40 | 9.82 | 192 | 396184 | 1319 | 52951371 |
Pericarditis | 360.22 | 9.82 | 32 | 396344 | 64374 | 52888316 |
Arthropathy | 322.30 | 9.82 | 345 | 396031 | 141108 | 52811582 |
Oedema peripheral | 322.20 | 9.82 | 2273 | 394103 | 168514 | 52784176 |
Alopecia | 297.46 | 9.82 | 831 | 395545 | 233752 | 52718938 |
Exposure during pregnancy | 296.36 | 9.82 | 294 | 396082 | 124566 | 52828124 |
Non-cardiogenic pulmonary oedema | 282.17 | 9.82 | 122 | 396254 | 499 | 52952191 |
Cerebrovascular accident | 273.44 | 9.82 | 1520 | 394856 | 103654 | 52849036 |
Fall | 272.37 | 9.82 | 3950 | 392426 | 354490 | 52598200 |
Bradycardia | 268.31 | 9.82 | 1143 | 395233 | 69913 | 52882777 |
Pain | 247.53 | 9.82 | 2992 | 393384 | 585406 | 52367284 |
Rheumatoid factor positive | 240.06 | 9.82 | 17 | 396359 | 41181 | 52911509 |
Wound | 228.45 | 9.82 | 206 | 396170 | 91351 | 52861339 |
Hepatic enzyme increased | 226.79 | 9.82 | 367 | 396009 | 125828 | 52826862 |
Hypersensitivity | 217.11 | 9.82 | 818 | 395558 | 209847 | 52742843 |
Orthostatic hypotension | 213.38 | 9.82 | 593 | 395783 | 29160 | 52923530 |
Hyperkalaemia | 202.66 | 9.82 | 870 | 395506 | 53386 | 52899304 |
Dizziness | 201.79 | 9.82 | 3883 | 392493 | 368376 | 52584314 |
Product use issue | 197.11 | 9.82 | 468 | 395908 | 139116 | 52813574 |
Vasoplegia syndrome | 191.09 | 9.82 | 118 | 396258 | 1134 | 52951556 |
Lactic acidosis | 189.64 | 9.82 | 659 | 395717 | 36594 | 52916096 |
Angioedema | 186.04 | 9.82 | 711 | 395665 | 41365 | 52911325 |
Renal impairment | 185.39 | 9.82 | 1156 | 395220 | 82162 | 52870528 |
Folliculitis | 184.99 | 9.82 | 13 | 396363 | 31696 | 52920994 |
Discomfort | 184.66 | 9.82 | 264 | 396112 | 95208 | 52857482 |
Duodenal ulcer perforation | 182.57 | 9.82 | 23 | 396353 | 35160 | 52917530 |
Abortion spontaneous | 181.38 | 9.82 | 60 | 396316 | 46575 | 52906115 |
Therapeutic product effect incomplete | 167.63 | 9.82 | 264 | 396112 | 91520 | 52861170 |
C-reactive protein abnormal | 165.45 | 9.82 | 6 | 396370 | 25864 | 52926826 |
Cardiac failure congestive | 162.30 | 9.82 | 1213 | 395163 | 91544 | 52861146 |
Abdominal discomfort | 162.18 | 9.82 | 970 | 395406 | 220092 | 52732598 |
Pregnancy | 157.34 | 9.82 | 23 | 396353 | 31418 | 52921272 |
Intentional overdose | 156.78 | 9.82 | 944 | 395432 | 66261 | 52886429 |
Metabolic acidosis | 156.69 | 9.82 | 676 | 395700 | 41566 | 52911124 |
Sinusitis | 154.48 | 9.82 | 685 | 395691 | 167879 | 52784811 |
Lower respiratory tract infection | 153.85 | 9.82 | 275 | 396101 | 90706 | 52861984 |
Helicobacter infection | 152.41 | 9.82 | 50 | 396326 | 39019 | 52913671 |
Sleep disorder due to general medical condition, insomnia type | 151.18 | 9.82 | 7 | 396369 | 24342 | 52928348 |
Arthralgia | 147.34 | 9.82 | 2340 | 394036 | 437443 | 52515247 |
Hypokalaemia | 145.18 | 9.82 | 1219 | 395157 | 95298 | 52857392 |
Swelling | 143.08 | 9.82 | 833 | 395543 | 190272 | 52762418 |
Toxicity to various agents | 141.14 | 9.82 | 2354 | 394022 | 217244 | 52735446 |
Infection | 140.77 | 9.82 | 729 | 395647 | 171476 | 52781214 |
Device expulsion | 139.85 | 9.82 | 26 | 396350 | 29787 | 52922903 |
Hypoglycaemia | 137.05 | 9.82 | 828 | 395548 | 58185 | 52894505 |
Muscle injury | 131.27 | 9.82 | 30 | 396346 | 29736 | 52922954 |
Hypertensive crisis | 129.60 | 9.82 | 314 | 396062 | 14192 | 52938498 |
Distributive shock | 126.26 | 9.82 | 81 | 396295 | 837 | 52951853 |
Injection site reaction | 125.37 | 9.82 | 117 | 396259 | 51049 | 52901641 |
Atrial fibrillation | 117.92 | 9.82 | 1309 | 395067 | 110343 | 52842347 |
Injection site erythema | 117.15 | 9.82 | 249 | 396127 | 77000 | 52875690 |
Myocardial infarction | 114.30 | 9.82 | 1185 | 395191 | 98169 | 52854521 |
Impaired healing | 113.16 | 9.82 | 189 | 396187 | 64016 | 52888674 |
Syncope | 111.95 | 9.82 | 1299 | 395077 | 110694 | 52841996 |
Drug abuse | 111.72 | 9.82 | 197 | 396179 | 65329 | 52887361 |
Neurologic neglect syndrome | 110.41 | 9.82 | 82 | 396294 | 1093 | 52951597 |
Condition aggravated | 109.65 | 9.82 | 1551 | 394825 | 295583 | 52657107 |
Joint swelling | 108.77 | 9.82 | 1166 | 395210 | 233472 | 52719218 |
Blood creatinine increased | 107.28 | 9.82 | 1011 | 395365 | 81651 | 52871039 |
Decreased appetite | 104.37 | 9.82 | 2207 | 394169 | 212767 | 52739923 |
Creatinine renal clearance decreased | 104.34 | 9.82 | 239 | 396137 | 10412 | 52942278 |
Rash | 103.21 | 9.82 | 2526 | 393850 | 443665 | 52509025 |
Musculoskeletal stiffness | 103.18 | 9.82 | 518 | 395858 | 122850 | 52829840 |
Balance disorder | 102.93 | 9.82 | 911 | 395465 | 72296 | 52880394 |
Depressed level of consciousness | 102.18 | 9.82 | 724 | 395652 | 53704 | 52898986 |
Injection site pain | 98.94 | 9.82 | 469 | 395907 | 112922 | 52839768 |
Carotid artery thrombosis | 98.28 | 9.82 | 78 | 396298 | 1154 | 52951536 |
Irritable bowel syndrome | 97.53 | 9.82 | 108 | 396268 | 43524 | 52909166 |
Ill-defined disorder | 96.29 | 9.82 | 136 | 396240 | 49308 | 52903382 |
Cerebral infarction | 95.93 | 9.82 | 398 | 395978 | 24046 | 52928644 |
Atrioventricular block complete | 95.88 | 9.82 | 195 | 396181 | 7820 | 52944870 |
Swollen tongue | 94.29 | 9.82 | 469 | 395907 | 30611 | 52922079 |
Sedation complication | 92.52 | 9.82 | 180 | 396196 | 6986 | 52945704 |
Pyrexia | 88.49 | 9.82 | 2300 | 394076 | 400893 | 52551797 |
Rhabdomyolysis | 87.60 | 9.82 | 593 | 395783 | 43330 | 52909360 |
Product prescribing error | 85.72 | 9.82 | 369 | 396007 | 22662 | 52930028 |
Live birth | 85.50 | 9.82 | 7 | 396369 | 15052 | 52937638 |
Blood pressure decreased | 82.92 | 9.82 | 762 | 395614 | 61107 | 52891583 |
Sinus bradycardia | 82.89 | 9.82 | 268 | 396108 | 14333 | 52938357 |
Migraine | 82.87 | 9.82 | 312 | 396064 | 80105 | 52872585 |
Asthenia | 81.01 | 9.82 | 3220 | 393156 | 340370 | 52612320 |
Renal failure | 80.90 | 9.82 | 1283 | 395093 | 117169 | 52835521 |
Foetal exposure during pregnancy | 80.86 | 9.82 | 83 | 396293 | 34632 | 52918058 |
Product use in unapproved indication | 79.48 | 9.82 | 498 | 395878 | 111791 | 52840899 |
Hypertensive emergency | 77.65 | 9.82 | 79 | 396297 | 1642 | 52951048 |
Sprue-like enteropathy | 76.60 | 9.82 | 47 | 396329 | 446 | 52952244 |
Subacute cutaneous lupus erythematosus | 76.14 | 9.82 | 91 | 396285 | 2277 | 52950413 |
Overdose | 74.73 | 9.82 | 1170 | 395206 | 106566 | 52846124 |
Intentional self-injury | 73.03 | 9.82 | 49 | 396327 | 25235 | 52927455 |
Febrile neutropenia | 72.92 | 9.82 | 468 | 395908 | 104468 | 52848222 |
Cardiac failure | 72.54 | 9.82 | 965 | 395411 | 84879 | 52867811 |
Atrioventricular block first degree | 72.33 | 9.82 | 154 | 396222 | 6381 | 52946309 |
Anuria | 72.13 | 9.82 | 230 | 396146 | 12210 | 52940480 |
Coronary artery disease | 70.65 | 9.82 | 458 | 395918 | 32979 | 52919711 |
Adjustment disorder | 70.39 | 9.82 | 79 | 396297 | 1844 | 52950846 |
Injection site swelling | 70.11 | 9.82 | 131 | 396245 | 42497 | 52910193 |
Hemiplegia | 69.84 | 9.82 | 169 | 396207 | 7631 | 52945059 |
Drug interaction | 69.50 | 9.82 | 2127 | 394249 | 217202 | 52735488 |
Cardiogenic shock | 68.09 | 9.82 | 284 | 396092 | 17198 | 52935492 |
Angina pectoris | 67.28 | 9.82 | 404 | 395972 | 28321 | 52924369 |
Infective pulmonary exacerbation of cystic fibrosis | 66.77 | 9.82 | 4 | 396372 | 11152 | 52941538 |
Blood urea increased | 64.71 | 9.82 | 374 | 396002 | 25857 | 52926833 |
Dehydration | 64.44 | 9.82 | 1673 | 394703 | 166737 | 52785953 |
Fibromyalgia | 64.39 | 9.82 | 145 | 396231 | 43930 | 52908760 |
Circulatory collapse | 62.80 | 9.82 | 334 | 396042 | 22380 | 52930310 |
Drug resistance | 62.79 | 9.82 | 35 | 396341 | 19927 | 52932763 |
Acute myocardial infarction | 61.73 | 9.82 | 441 | 395935 | 32794 | 52919896 |
Chronic kidney disease | 61.61 | 9.82 | 541 | 395835 | 42829 | 52909861 |
Hip arthroplasty | 61.14 | 9.82 | 70 | 396306 | 27792 | 52924898 |
Loss of personal independence in daily activities | 60.15 | 9.82 | 290 | 396086 | 69525 | 52883165 |
Linear IgA disease | 60.09 | 9.82 | 64 | 396312 | 1406 | 52951284 |
Renin increased | 59.92 | 9.82 | 29 | 396347 | 162 | 52952528 |
Psoriatic arthropathy | 59.25 | 9.82 | 173 | 396203 | 48017 | 52904673 |
Gastrointestinal disorder | 59.21 | 9.82 | 408 | 395968 | 89596 | 52863094 |
Palpitations | 57.36 | 9.82 | 1074 | 395302 | 101274 | 52851416 |
Stomatitis | 56.94 | 9.82 | 461 | 395915 | 97697 | 52854993 |
Blood calcium decreased | 56.06 | 9.82 | 293 | 396083 | 19501 | 52933189 |
Injection site pruritus | 55.85 | 9.82 | 143 | 396233 | 41446 | 52911244 |
Pulmonary oedema | 55.83 | 9.82 | 628 | 395748 | 53095 | 52899595 |
Intentional product use issue | 55.79 | 9.82 | 313 | 396063 | 72181 | 52880509 |
Transient ischaemic attack | 55.70 | 9.82 | 455 | 395921 | 35270 | 52917420 |
Hyperglycaemia | 54.87 | 9.82 | 496 | 395880 | 39588 | 52913102 |
Inappropriate antidiuretic hormone secretion | 53.70 | 9.82 | 237 | 396139 | 14714 | 52937976 |
Blood pressure systolic increased | 53.22 | 9.82 | 445 | 395931 | 34732 | 52917958 |
Left ventricular hypertrophy | 52.04 | 9.82 | 118 | 396258 | 5105 | 52947585 |
Blood glucose increased | 51.69 | 9.82 | 835 | 395541 | 76526 | 52876164 |
Renal artery stenosis | 50.57 | 9.82 | 66 | 396310 | 1810 | 52950880 |
Rheumatoid nodule | 50.27 | 9.82 | 13 | 396363 | 11851 | 52940839 |
Cognitive disorder | 50.01 | 9.82 | 531 | 395845 | 44247 | 52908443 |
Personality disorder | 50.00 | 9.82 | 101 | 396275 | 4030 | 52948660 |
Melaena | 49.81 | 9.82 | 379 | 395997 | 28750 | 52923940 |
Abortion induced | 49.59 | 9.82 | 10 | 396366 | 10816 | 52941874 |
Dysarthria | 49.07 | 9.82 | 489 | 395887 | 40079 | 52912611 |
Neutropenia | 48.82 | 9.82 | 860 | 395516 | 158325 | 52794365 |
Atrioventricular block | 47.95 | 9.82 | 139 | 396237 | 7001 | 52945689 |
Diabetes mellitus inadequate control | 47.78 | 9.82 | 222 | 396154 | 14088 | 52938602 |
Proteinuria | 46.79 | 9.82 | 261 | 396115 | 17807 | 52934883 |
Pemphigoid | 46.75 | 9.82 | 129 | 396247 | 6315 | 52946375 |
Malaise | 46.23 | 9.82 | 3166 | 393210 | 354451 | 52598239 |
Hepatic function abnormal | 46.21 | 9.82 | 448 | 395928 | 36451 | 52916239 |
Anaemia | 45.67 | 9.82 | 2503 | 393873 | 274215 | 52678475 |
Glomerular filtration rate decreased | 45.56 | 9.82 | 202 | 396174 | 12565 | 52940125 |
Oedema | 45.47 | 9.82 | 791 | 395585 | 73555 | 52879135 |
Vasodilatation | 45.12 | 9.82 | 73 | 396303 | 2444 | 52950246 |
Renal disorder | 44.82 | 9.82 | 370 | 396006 | 28769 | 52923921 |
Drug level increased | 44.54 | 9.82 | 282 | 396094 | 20139 | 52932551 |
Caesarean section | 44.34 | 9.82 | 38 | 396338 | 17282 | 52935408 |
Injection site warmth | 44.11 | 9.82 | 25 | 396351 | 14103 | 52938587 |
Hypomagnesaemia | 43.65 | 9.82 | 325 | 396051 | 24486 | 52928204 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 43.26 | 9.82 | 69 | 396307 | 2282 | 52950408 |
Suicide attempt | 43.12 | 9.82 | 639 | 395737 | 57529 | 52895161 |
Injection site bruising | 42.84 | 9.82 | 140 | 396236 | 37506 | 52915184 |
Oliguria | 42.38 | 9.82 | 158 | 396218 | 9080 | 52943610 |
Device dislocation | 41.99 | 9.82 | 69 | 396307 | 23528 | 52929162 |
Drug dependence | 41.86 | 9.82 | 59 | 396317 | 21413 | 52931277 |
Body temperature increased | 41.60 | 9.82 | 116 | 396260 | 32683 | 52920007 |
Foot deformity | 41.45 | 9.82 | 46 | 396330 | 18522 | 52934168 |
Carotid artery stenosis | 41.01 | 9.82 | 109 | 396267 | 5218 | 52947472 |
Dyspnoea | 40.98 | 9.82 | 4963 | 391413 | 581269 | 52371421 |
Haemorrhage subcutaneous | 40.34 | 9.82 | 78 | 396298 | 3013 | 52949677 |
Tenosynovitis | 40.05 | 9.82 | 12 | 396364 | 9927 | 52942763 |
Septic shock | 39.98 | 9.82 | 284 | 396092 | 61945 | 52890745 |
Premature labour | 39.87 | 9.82 | 21 | 396355 | 12341 | 52940349 |
Suspected suicide | 39.50 | 9.82 | 95 | 396281 | 4273 | 52948417 |
Ischaemic stroke | 38.34 | 9.82 | 247 | 396129 | 17746 | 52934944 |
Knee arthroplasty | 38.08 | 9.82 | 125 | 396251 | 33444 | 52919246 |
Altered state of consciousness | 38.00 | 9.82 | 315 | 396061 | 24521 | 52928169 |
Drug withdrawal syndrome | 37.90 | 9.82 | 96 | 396280 | 27926 | 52924764 |
Multiple sclerosis relapse | 37.66 | 9.82 | 188 | 396188 | 44665 | 52908025 |
Glomerulonephritis rapidly progressive | 37.46 | 9.82 | 38 | 396338 | 787 | 52951903 |
Blood creatine phosphokinase increased | 37.32 | 9.82 | 354 | 396022 | 28631 | 52924059 |
Blood potassium decreased | 37.19 | 9.82 | 462 | 395914 | 39998 | 52912692 |
Gastrointestinal haemorrhage | 35.49 | 9.82 | 814 | 395562 | 79516 | 52873174 |
Urticaria | 35.29 | 9.82 | 755 | 395621 | 135130 | 52817560 |
Aortic dissection | 35.17 | 9.82 | 53 | 396323 | 1667 | 52951023 |
Atrioventricular block second degree | 34.90 | 9.82 | 85 | 396291 | 3854 | 52948836 |
Supraventricular extrasystoles | 34.86 | 9.82 | 91 | 396285 | 4309 | 52948381 |
Lacunar infarction | 34.79 | 9.82 | 80 | 396296 | 3494 | 52949196 |
Weight increased | 34.57 | 9.82 | 1208 | 395168 | 203359 | 52749331 |
Chest pain | 34.30 | 9.82 | 1735 | 394641 | 188450 | 52764240 |
Eating disorder | 34.30 | 9.82 | 222 | 396154 | 15975 | 52936715 |
Nodal rhythm | 34.25 | 9.82 | 53 | 396323 | 1707 | 52950983 |
Bladder irritation | 34.25 | 9.82 | 21 | 396355 | 199 | 52952491 |
Premature baby | 34.22 | 9.82 | 59 | 396317 | 19742 | 52932948 |
Premature delivery | 34.10 | 9.82 | 91 | 396285 | 26013 | 52926677 |
Haematochezia | 34.05 | 9.82 | 472 | 395904 | 41886 | 52910804 |
Gingival swelling | 34.01 | 9.82 | 88 | 396288 | 4144 | 52948546 |
Hyperdynamic left ventricle | 33.98 | 9.82 | 19 | 396357 | 149 | 52952541 |
Metastases to bone | 33.95 | 9.82 | 57 | 396319 | 19271 | 52933419 |
Unintended pregnancy | 33.85 | 9.82 | 3 | 396373 | 6050 | 52946640 |
Colitis ulcerative | 33.51 | 9.82 | 66 | 396310 | 20995 | 52931695 |
Lip swelling | 33.44 | 9.82 | 329 | 396047 | 26872 | 52925818 |
Loss of consciousness | 33.34 | 9.82 | 1097 | 395279 | 113115 | 52839575 |
Drug tolerance decreased | 33.28 | 9.82 | 7 | 396369 | 7351 | 52945339 |
Red blood cell sedimentation rate increased | 32.86 | 9.82 | 103 | 396273 | 27954 | 52924736 |
Glycosylated haemoglobin increased | 31.96 | 9.82 | 171 | 396205 | 11484 | 52941206 |
Stillbirth | 31.72 | 9.82 | 6 | 396370 | 6791 | 52945899 |
Uterine perforation | 31.68 | 9.82 | 8 | 396368 | 7411 | 52945279 |
Ear pain | 31.29 | 9.82 | 114 | 396262 | 29559 | 52923131 |
Arrhythmia | 31.28 | 9.82 | 414 | 395962 | 36365 | 52916325 |
Pulmonary renal syndrome | 31.10 | 9.82 | 25 | 396351 | 377 | 52952313 |
Hepatotoxicity | 30.82 | 9.82 | 105 | 396271 | 27775 | 52924915 |
Intestinal malrotation | 30.78 | 9.82 | 25 | 396351 | 383 | 52952307 |
Injury | 30.65 | 9.82 | 237 | 396139 | 50734 | 52901956 |
Urine output decreased | 30.17 | 9.82 | 168 | 396208 | 11455 | 52941235 |
Ovarian cyst | 29.72 | 9.82 | 42 | 396334 | 15227 | 52937463 |
Psychotic disorder | 29.64 | 9.82 | 88 | 396288 | 24297 | 52928393 |
Therapeutic response decreased | 29.64 | 9.82 | 219 | 396157 | 47350 | 52905340 |
Sedation | 29.52 | 9.82 | 344 | 396032 | 29331 | 52923359 |
Allergic reaction to excipient | 29.48 | 9.82 | 24 | 396352 | 369 | 52952321 |
Hyperuricaemia | 29.41 | 9.82 | 96 | 396280 | 5160 | 52947530 |
Heavy menstrual bleeding | 28.92 | 9.82 | 53 | 396323 | 17323 | 52935367 |
Hyperaldosteronism | 28.71 | 9.82 | 21 | 396355 | 273 | 52952417 |
Injection site urticaria | 28.39 | 9.82 | 31 | 396345 | 12576 | 52940114 |
Loose tooth | 28.30 | 9.82 | 71 | 396305 | 3280 | 52949410 |
Hypocalcaemia | 28.27 | 9.82 | 338 | 396038 | 28999 | 52923691 |
Muscle spasms | 28.19 | 9.82 | 1248 | 395128 | 133547 | 52819143 |
Product monitoring error | 28.07 | 9.82 | 65 | 396311 | 2852 | 52949838 |
Blood pressure abnormal | 28.06 | 9.82 | 184 | 396192 | 13299 | 52939391 |
Angina unstable | 28.05 | 9.82 | 120 | 396256 | 7348 | 52945342 |
Bundle branch block right | 28.04 | 9.82 | 93 | 396283 | 5040 | 52947650 |
Nocturia | 28.03 | 9.82 | 122 | 396254 | 7528 | 52945162 |
Fatigue | 27.81 | 9.82 | 4891 | 391485 | 725615 | 52227075 |
Pollakiuria | 27.73 | 9.82 | 304 | 396072 | 25535 | 52927155 |
Hypoglycaemic coma | 27.55 | 9.82 | 61 | 396315 | 2597 | 52950093 |
Gingival bleeding | 27.49 | 9.82 | 171 | 396205 | 12137 | 52940553 |
Parkinsonism | 27.33 | 9.82 | 136 | 396240 | 8877 | 52943813 |
Aphasia | 27.24 | 9.82 | 349 | 396027 | 30429 | 52922261 |
Sinus arrest | 27.15 | 9.82 | 49 | 396327 | 1795 | 52950895 |
Schizophrenia | 27.00 | 9.82 | 22 | 396354 | 10257 | 52942433 |
Constipation | 26.71 | 9.82 | 1763 | 394613 | 196649 | 52756041 |
Blister | 26.57 | 9.82 | 418 | 395958 | 78335 | 52874355 |
Haematemesis | 26.51 | 9.82 | 348 | 396028 | 30509 | 52922181 |
Nasopharyngitis | 26.49 | 9.82 | 1163 | 395213 | 191132 | 52761558 |
Nephrosclerosis | 26.48 | 9.82 | 35 | 396341 | 972 | 52951718 |
Immunodeficiency | 26.41 | 9.82 | 44 | 396332 | 14923 | 52937767 |
Ischaemia | 26.35 | 9.82 | 86 | 396290 | 4622 | 52948068 |
Pathogen resistance | 26.29 | 9.82 | 8 | 396368 | 6552 | 52946138 |
Feeling abnormal | 25.98 | 9.82 | 1242 | 395134 | 134059 | 52818631 |
Seizure | 25.91 | 9.82 | 748 | 395628 | 128761 | 52823929 |
Panniculitis | 25.61 | 9.82 | 13 | 396363 | 7801 | 52944889 |
Motor dysfunction | 25.56 | 9.82 | 126 | 396250 | 8192 | 52944498 |
Leukopenia | 25.09 | 9.82 | 389 | 395987 | 73074 | 52879616 |
Blood potassium increased | 25.05 | 9.82 | 222 | 396154 | 17619 | 52935071 |
Respiratory failure | 25.01 | 9.82 | 948 | 395428 | 99564 | 52853126 |
Device difficult to use | 25.00 | 9.82 | 24 | 396352 | 10335 | 52942355 |
Accidental exposure to product | 24.93 | 9.82 | 91 | 396285 | 23583 | 52929107 |
Anaphylactic reaction | 24.93 | 9.82 | 295 | 396081 | 58031 | 52894659 |
Product label on wrong product | 24.89 | 9.82 | 7 | 396369 | 3 | 52952687 |
Confusional state | 24.77 | 9.82 | 1718 | 394658 | 192503 | 52760187 |
Mucosal inflammation | 24.77 | 9.82 | 201 | 396175 | 42583 | 52910107 |
Affect lability | 24.66 | 9.82 | 136 | 396240 | 9239 | 52943451 |
Cholecystitis chronic | 24.66 | 9.82 | 25 | 396351 | 10493 | 52942197 |
Unintentional medical device removal | 24.62 | 9.82 | 5 | 396371 | 5381 | 52947309 |
Haematotoxicity | 24.62 | 9.82 | 14 | 396362 | 7883 | 52944807 |
Foetal death | 24.55 | 9.82 | 20 | 396356 | 9327 | 52943363 |
Acute myeloid leukaemia | 24.48 | 9.82 | 56 | 396320 | 16876 | 52935814 |
Bone erosion | 24.48 | 9.82 | 28 | 396348 | 11124 | 52941566 |
Faeces discoloured | 24.28 | 9.82 | 219 | 396157 | 17467 | 52935223 |
Enthesopathy | 24.24 | 9.82 | 9 | 396367 | 6502 | 52946188 |
Dyspnoea exertional | 24.19 | 9.82 | 557 | 395819 | 54443 | 52898247 |
Labile hypertension | 24.17 | 9.82 | 24 | 396352 | 484 | 52952206 |
Product substitution issue | 24.15 | 9.82 | 201 | 396175 | 15665 | 52937025 |
Fear of injection | 23.92 | 9.82 | 6 | 396370 | 5583 | 52947107 |
BRASH syndrome | 23.88 | 9.82 | 16 | 396360 | 179 | 52952511 |
Multiple sclerosis | 23.84 | 9.82 | 112 | 396264 | 27041 | 52925649 |
Joint effusion | 23.80 | 9.82 | 39 | 396337 | 13313 | 52939377 |
Ageusia | 23.78 | 9.82 | 168 | 396208 | 12446 | 52940244 |
Schizoaffective disorder | 23.74 | 9.82 | 51 | 396325 | 2126 | 52950564 |
Gangrene | 23.71 | 9.82 | 85 | 396291 | 4792 | 52947898 |
Scleral discolouration | 23.40 | 9.82 | 21 | 396355 | 371 | 52952319 |
Myocardial depression | 23.40 | 9.82 | 23 | 396353 | 458 | 52952232 |
Generalised oedema | 23.37 | 9.82 | 192 | 396184 | 14907 | 52937783 |
Amenorrhoea | 23.34 | 9.82 | 21 | 396355 | 9328 | 52943362 |
Chronic pigmented purpura | 23.32 | 9.82 | 12 | 396364 | 78 | 52952612 |
Listless | 23.26 | 9.82 | 56 | 396320 | 2520 | 52950170 |
Hemiparesis | 23.20 | 9.82 | 253 | 396123 | 21222 | 52931468 |
Swelling face | 23.03 | 9.82 | 572 | 395804 | 56596 | 52896094 |
Myocardial ischaemia | 23.02 | 9.82 | 169 | 396207 | 12675 | 52940015 |
Arteriosclerosis | 22.91 | 9.82 | 141 | 396235 | 9970 | 52942720 |
Mood swings | 22.81 | 9.82 | 61 | 396315 | 17425 | 52935265 |
Subdural haematoma | 22.65 | 9.82 | 178 | 396198 | 13635 | 52939055 |
Gastric ulcer haemorrhage | 22.55 | 9.82 | 86 | 396290 | 4996 | 52947694 |
Dysgeusia | 22.50 | 9.82 | 446 | 395930 | 42485 | 52910205 |
Metabolic alkalosis | 22.46 | 9.82 | 61 | 396315 | 2958 | 52949732 |
Bradyarrhythmia | 22.44 | 9.82 | 48 | 396328 | 1995 | 52950695 |
Hypertensive heart disease | 22.24 | 9.82 | 55 | 396321 | 2518 | 52950172 |
Tongue oedema | 22.15 | 9.82 | 76 | 396300 | 4191 | 52948499 |
Conjoined twins | 22.15 | 9.82 | 18 | 396358 | 276 | 52952414 |
Acute coronary syndrome | 22.15 | 9.82 | 143 | 396233 | 10281 | 52942409 |
Myalgia | 22.07 | 9.82 | 1208 | 395168 | 132283 | 52820407 |
Ear infection | 22.06 | 9.82 | 108 | 396268 | 25792 | 52926898 |
Multiple drug therapy | 21.89 | 9.82 | 39 | 396337 | 1414 | 52951276 |
Prescription drug used without a prescription | 21.88 | 9.82 | 44 | 396332 | 1750 | 52950940 |
Fibromuscular dysplasia | 21.88 | 9.82 | 16 | 396360 | 208 | 52952482 |
Lymphocyte stimulation test positive | 21.86 | 9.82 | 25 | 396351 | 596 | 52952094 |
Harlequin syndrome | 21.78 | 9.82 | 9 | 396367 | 32 | 52952658 |
Premature rupture of membranes | 21.74 | 9.82 | 5 | 396371 | 4935 | 52947755 |
Lichen nitidus | 21.69 | 9.82 | 11 | 396365 | 69 | 52952621 |
Device issue | 21.67 | 9.82 | 85 | 396291 | 21573 | 52931117 |
Injection site rash | 21.50 | 9.82 | 58 | 396318 | 16521 | 52936169 |
Staphylococcal infection | 21.45 | 9.82 | 183 | 396193 | 38365 | 52914325 |
Retinal ischaemia | 21.43 | 9.82 | 19 | 396357 | 330 | 52952360 |
Bone marrow failure | 21.06 | 9.82 | 134 | 396242 | 29981 | 52922709 |
Carotid arteriosclerosis | 21.04 | 9.82 | 32 | 396344 | 1015 | 52951675 |
Irritability | 21 | 9.82 | 139 | 396237 | 30814 | 52921876 |
Aortic aneurysm | 20.94 | 9.82 | 66 | 396310 | 3482 | 52949208 |
Lymphocele | 20.92 | 9.82 | 29 | 396347 | 844 | 52951846 |
Therapy partial responder | 20.58 | 9.82 | 10 | 396366 | 6153 | 52946537 |
Status epilepticus | 20.55 | 9.82 | 52 | 396324 | 15132 | 52937558 |
Cerebral haemorrhage | 20.49 | 9.82 | 325 | 396051 | 29671 | 52923019 |
Urinary retention | 20.43 | 9.82 | 311 | 396065 | 28155 | 52924535 |
Urine albumin/creatinine ratio increased | 20.37 | 9.82 | 16 | 396360 | 233 | 52952457 |
Presyncope | 20.29 | 9.82 | 290 | 396086 | 25904 | 52926786 |
Gestational diabetes | 20.14 | 9.82 | 18 | 396358 | 8021 | 52944669 |
Wrong technique in product usage process | 20.12 | 9.82 | 319 | 396057 | 59713 | 52892977 |
Heart rate decreased | 20.09 | 9.82 | 386 | 395990 | 36561 | 52916129 |
Tubulointerstitial nephritis | 19.99 | 9.82 | 199 | 396177 | 16305 | 52936385 |
Hypoperfusion | 19.98 | 9.82 | 37 | 396339 | 1383 | 52951307 |
No adverse event | 19.85 | 9.82 | 191 | 396185 | 39074 | 52913616 |
Dementia | 19.82 | 9.82 | 201 | 396175 | 16549 | 52936141 |
Galactorrhoea | 19.81 | 9.82 | 3 | 396373 | 3992 | 52948698 |
Blood aldosterone increased | 19.80 | 9.82 | 14 | 396362 | 172 | 52952518 |
Sensory loss | 19.68 | 9.82 | 113 | 396263 | 7792 | 52944898 |
Gingival atrophy | 19.67 | 9.82 | 8 | 396368 | 27 | 52952663 |
Haemodynamic instability | 19.57 | 9.82 | 120 | 396256 | 8474 | 52944216 |
Retinopathy hypertensive | 19.54 | 9.82 | 16 | 396360 | 248 | 52952442 |
Hypoglossal nerve paralysis | 19.46 | 9.82 | 7 | 396369 | 15 | 52952675 |
Grip strength decreased | 19.41 | 9.82 | 36 | 396340 | 11713 | 52940977 |
Head discomfort | 19.40 | 9.82 | 151 | 396225 | 11533 | 52941157 |
Vertigo | 19.38 | 9.82 | 550 | 395826 | 55531 | 52897159 |
Haemodialysis | 19.36 | 9.82 | 128 | 396248 | 9276 | 52943414 |
Acute motor-sensory axonal neuropathy | 19.21 | 9.82 | 18 | 396358 | 337 | 52952353 |
Disability | 19.17 | 9.82 | 40 | 396336 | 12458 | 52940232 |
Suicidal ideation | 19.14 | 9.82 | 325 | 396051 | 60186 | 52892504 |
Protein urine present | 19.08 | 9.82 | 88 | 396288 | 5566 | 52947124 |
Osteopenia | 19.04 | 9.82 | 71 | 396305 | 18284 | 52934406 |
Disorientation | 19.01 | 9.82 | 404 | 395972 | 38955 | 52913735 |
Diabetic nephropathy | 18.94 | 9.82 | 37 | 396339 | 1440 | 52951250 |
C-reactive protein increased | 18.85 | 9.82 | 373 | 396003 | 67513 | 52885177 |
Gallbladder adenocarcinoma | 18.79 | 9.82 | 11 | 396365 | 95 | 52952595 |
Oral discharge | 18.64 | 9.82 | 13 | 396363 | 156 | 52952534 |
Putamen haemorrhage | 18.52 | 9.82 | 14 | 396362 | 192 | 52952498 |
Mydriasis | 18.45 | 9.82 | 35 | 396341 | 11291 | 52941399 |
Pseudolymphoma | 18.27 | 9.82 | 23 | 396353 | 608 | 52952082 |
Rectourethral fistula | 18.26 | 9.82 | 8 | 396368 | 34 | 52952656 |
Blood uric acid increased | 18.23 | 9.82 | 72 | 396304 | 4252 | 52948438 |
Nephrogenic systemic fibrosis | 18.22 | 9.82 | 77 | 396299 | 4690 | 52948000 |
Tendonitis | 18.15 | 9.82 | 65 | 396311 | 16941 | 52935749 |
Post transplant lymphoproliferative disorder | 18.12 | 9.82 | 5 | 396371 | 4366 | 52948324 |
Interstitial lung disease | 18.12 | 9.82 | 567 | 395809 | 58055 | 52894635 |
Cytomegalovirus infection | 18.11 | 9.82 | 79 | 396297 | 19460 | 52933230 |
Electrocardiogram abnormal | 18.03 | 9.82 | 113 | 396263 | 8040 | 52944650 |
Inflammation | 18.03 | 9.82 | 307 | 396069 | 56829 | 52895861 |
Gingivitis | 17.80 | 9.82 | 111 | 396265 | 7884 | 52944806 |
Acute hepatic failure | 17.79 | 9.82 | 64 | 396312 | 16656 | 52936034 |
Gravitational oedema | 17.68 | 9.82 | 33 | 396343 | 1241 | 52951449 |
Device adhesion issue | 17.65 | 9.82 | 3 | 396373 | 3667 | 52949023 |
Diarrhoea | 17.64 | 9.82 | 5056 | 391320 | 620490 | 52332200 |
Venoocclusive liver disease | 17.57 | 9.82 | 6 | 396370 | 4566 | 52948124 |
Pulse abnormal | 17.54 | 9.82 | 41 | 396335 | 1810 | 52950880 |
Skin tightness | 17.52 | 9.82 | 68 | 396308 | 3983 | 52948707 |
Hypernatraemia | 17.41 | 9.82 | 100 | 396276 | 6897 | 52945793 |
Dysphoria | 17.38 | 9.82 | 9 | 396367 | 5340 | 52947350 |
Diabetes mellitus | 17.37 | 9.82 | 524 | 395852 | 53375 | 52899315 |
Pancreatic toxicity | 17.35 | 9.82 | 7 | 396369 | 23 | 52952667 |
Sinus rhythm | 17.32 | 9.82 | 24 | 396352 | 698 | 52951992 |
Sickle cell anaemia with crisis | 17.29 | 9.82 | 6 | 396370 | 4521 | 52948169 |
Vitello-intestinal duct remnant | 17.24 | 9.82 | 8 | 396368 | 40 | 52952650 |
Medication error | 17.16 | 9.82 | 372 | 396004 | 35993 | 52916697 |
Suspected product quality issue | 17.15 | 9.82 | 13 | 396363 | 179 | 52952511 |
Hyperkaliuria | 17.12 | 9.82 | 10 | 396366 | 86 | 52952604 |
Injection site haemorrhage | 17.07 | 9.82 | 95 | 396281 | 21956 | 52930734 |
Nephrogenic anaemia | 17.07 | 9.82 | 42 | 396334 | 1917 | 52950773 |
Fryns syndrome | 17.06 | 9.82 | 9 | 396367 | 62 | 52952628 |
Crohn's disease | 17.05 | 9.82 | 15 | 396361 | 6735 | 52945955 |
Haemoglobin decreased | 17.05 | 9.82 | 1212 | 395164 | 136095 | 52816595 |
Product storage error | 16.98 | 9.82 | 46 | 396330 | 13084 | 52939606 |
Intestinal villi atrophy | 16.97 | 9.82 | 13 | 396363 | 182 | 52952508 |
Complication of device insertion | 16.93 | 9.82 | 12 | 396364 | 6005 | 52946685 |
Blood glucose decreased | 16.89 | 9.82 | 225 | 396151 | 19791 | 52932899 |
Transcription medication error | 16.81 | 9.82 | 15 | 396361 | 263 | 52952427 |
Thirst | 16.80 | 9.82 | 145 | 396231 | 11421 | 52941269 |
Blood sodium decreased | 16.76 | 9.82 | 253 | 396123 | 22863 | 52929827 |
Upper respiratory tract infection | 16.76 | 9.82 | 388 | 395988 | 68709 | 52883981 |
Taste disorder | 16.74 | 9.82 | 109 | 396267 | 7859 | 52944831 |
Rectal ulcer haemorrhage | 16.68 | 9.82 | 13 | 396363 | 187 | 52952503 |
Anorexia nervosa | 16.62 | 9.82 | 13 | 396363 | 188 | 52952502 |
Congenital bladder anomaly | 16.62 | 9.82 | 13 | 396363 | 188 | 52952502 |
Blood lactic acid increased | 16.59 | 9.82 | 88 | 396288 | 5890 | 52946800 |
Hypothermia | 16.58 | 9.82 | 159 | 396217 | 12897 | 52939793 |
Crush syndrome | 16.57 | 9.82 | 11 | 396365 | 121 | 52952569 |
Hypertensive encephalopathy | 16.55 | 9.82 | 23 | 396353 | 671 | 52952019 |
Aggression | 16.43 | 9.82 | 104 | 396272 | 23299 | 52929391 |
Urachal abnormality | 16.40 | 9.82 | 13 | 396363 | 192 | 52952498 |
Dermatosis | 16.34 | 9.82 | 16 | 396360 | 317 | 52952373 |
Blood loss anaemia | 16.34 | 9.82 | 117 | 396259 | 8706 | 52943984 |
Benign neoplasm of adrenal gland | 16.31 | 9.82 | 7 | 396369 | 28 | 52952662 |
Granuloma skin | 16.26 | 9.82 | 9 | 396367 | 5145 | 52947545 |
Generalised tonic-clonic seizure | 16.24 | 9.82 | 136 | 396240 | 28622 | 52924068 |
Cytokine release syndrome | 16.18 | 9.82 | 22 | 396354 | 8107 | 52944583 |
Neurotoxicity | 16.16 | 9.82 | 59 | 396317 | 15290 | 52937400 |
Ankylosing spondylitis | 16.16 | 9.82 | 22 | 396354 | 8103 | 52944587 |
Hallucination, gustatory | 16.16 | 9.82 | 9 | 396367 | 70 | 52952620 |
Vaginal haemorrhage | 16.04 | 9.82 | 125 | 396251 | 26716 | 52925974 |
Periodontitis | 16.02 | 9.82 | 59 | 396317 | 3370 | 52949320 |
Agitation | 16.01 | 9.82 | 323 | 396053 | 58303 | 52894387 |
Ventricular failure | 15.94 | 9.82 | 18 | 396358 | 423 | 52952267 |
Hyperlipidaemia | 15.90 | 9.82 | 218 | 396158 | 19297 | 52933393 |
Intermenstrual bleeding | 15.88 | 9.82 | 25 | 396351 | 8673 | 52944017 |
Sleep disorder | 15.88 | 9.82 | 325 | 396051 | 58545 | 52894145 |
Febrile bone marrow aplasia | 15.84 | 9.82 | 18 | 396358 | 7171 | 52945519 |
Hyperplastic cholecystopathy | 15.78 | 9.82 | 10 | 396366 | 101 | 52952589 |
Bursitis | 15.77 | 9.82 | 100 | 396276 | 22392 | 52930298 |
CD30 expression | 15.76 | 9.82 | 7 | 396369 | 31 | 52952659 |
Reduced facial expression | 15.70 | 9.82 | 38 | 396338 | 1716 | 52950974 |
Maternal drugs affecting foetus | 15.68 | 9.82 | 11 | 396365 | 5535 | 52947155 |
Drug hypersensitivity | 15.68 | 9.82 | 1728 | 394648 | 263514 | 52689176 |
Autoimmune enteropathy | 15.65 | 9.82 | 5 | 396371 | 6 | 52952684 |
Hypergastrinaemia | 15.61 | 9.82 | 10 | 396366 | 103 | 52952587 |
Upper gastrointestinal haemorrhage | 15.57 | 9.82 | 198 | 396178 | 17232 | 52935458 |
Device deployment issue | 15.55 | 9.82 | 4 | 396372 | 3660 | 52949030 |
Full blood count decreased | 15.53 | 9.82 | 258 | 396118 | 23771 | 52928919 |
Lichen planus | 15.52 | 9.82 | 42 | 396334 | 2032 | 52950658 |
Gastrointestinal toxicity | 15.49 | 9.82 | 8 | 396368 | 4754 | 52947936 |
Substance abuse | 15.45 | 9.82 | 7 | 396369 | 4487 | 52948203 |
Persistent cloaca | 15.44 | 9.82 | 13 | 396363 | 210 | 52952480 |
Renal cell carcinoma | 15.42 | 9.82 | 60 | 396316 | 3519 | 52949171 |
Haemorrhagic erosive gastritis | 15.41 | 9.82 | 15 | 396361 | 295 | 52952395 |
Cystic fibrosis | 15.38 | 9.82 | 5 | 396371 | 3926 | 52948764 |
Mental status changes | 15.36 | 9.82 | 394 | 395982 | 39177 | 52913513 |
Gout | 15.25 | 9.82 | 150 | 396226 | 12249 | 52940441 |
Cardiac disorder | 15.24 | 9.82 | 457 | 395919 | 46509 | 52906181 |
Lymphocyte count decreased | 15.24 | 9.82 | 134 | 396242 | 27918 | 52924772 |
Nodule | 15.24 | 9.82 | 72 | 396304 | 17357 | 52935333 |
Peripheral arterial occlusive disease | 15.21 | 9.82 | 64 | 396312 | 3890 | 52948800 |
Blood cholinesterase decreased | 15.17 | 9.82 | 11 | 396365 | 141 | 52952549 |
Duodenal ulcer | 15.16 | 9.82 | 103 | 396273 | 7533 | 52945157 |
Cerebral ischaemia | 15.13 | 9.82 | 93 | 396283 | 6572 | 52946118 |
Dystonia | 15.11 | 9.82 | 48 | 396328 | 12973 | 52939717 |
Infected dermal cyst | 15.10 | 9.82 | 18 | 396358 | 449 | 52952241 |
Electrolyte imbalance | 15.00 | 9.82 | 210 | 396166 | 18674 | 52934016 |
Device malfunction | 14.94 | 9.82 | 64 | 396312 | 15844 | 52936846 |
Diverticulum intestinal haemorrhagic | 14.88 | 9.82 | 31 | 396345 | 1265 | 52951425 |
Adenoma benign | 14.85 | 9.82 | 24 | 396352 | 803 | 52951887 |
Blood parathyroid hormone decreased | 14.83 | 9.82 | 15 | 396361 | 6303 | 52946387 |
Burn oesophageal | 14.82 | 9.82 | 12 | 396364 | 183 | 52952507 |
Retroperitoneal oedema | 14.81 | 9.82 | 6 | 396370 | 20 | 52952670 |
Neovascularisation | 14.77 | 9.82 | 21 | 396355 | 626 | 52952064 |
Skin discolouration | 14.73 | 9.82 | 354 | 396022 | 34838 | 52917852 |
Pleural effusion | 14.72 | 9.82 | 802 | 395574 | 87777 | 52864913 |
Albuminuria | 14.70 | 9.82 | 13 | 396363 | 225 | 52952465 |
Purpura | 14.70 | 9.82 | 134 | 396242 | 10719 | 52941971 |
Dialysis | 14.68 | 9.82 | 129 | 396247 | 10213 | 52942477 |
Insulin-like growth factor decreased | 14.65 | 9.82 | 17 | 396359 | 412 | 52952278 |
Ventricular septal defect | 14.61 | 9.82 | 7 | 396369 | 4343 | 52948347 |
Mitral valve incompetence | 14.57 | 9.82 | 215 | 396161 | 19336 | 52933354 |
Cardiac failure chronic | 14.56 | 9.82 | 64 | 396312 | 3966 | 52948724 |
Saliva discolouration | 14.48 | 9.82 | 7 | 396369 | 39 | 52952651 |
Apical granuloma | 14.48 | 9.82 | 7 | 396369 | 39 | 52952651 |
Hypertensive angiopathy | 14.44 | 9.82 | 9 | 396367 | 88 | 52952602 |
Dermatitis bullous | 14.40 | 9.82 | 107 | 396269 | 8056 | 52944634 |
Soft tissue disorder | 14.26 | 9.82 | 7 | 396369 | 4283 | 52948407 |
Organ failure | 14.24 | 9.82 | 48 | 396328 | 2623 | 52950067 |
Menstruation irregular | 14.19 | 9.82 | 19 | 396357 | 7047 | 52945643 |
Facial nerve disorder | 14.15 | 9.82 | 20 | 396356 | 593 | 52952097 |
Bromhidrosis | 14.13 | 9.82 | 5 | 396371 | 10 | 52952680 |
Body tinea | 14.10 | 9.82 | 29 | 396347 | 1172 | 52951518 |
Genital haemorrhage | 14.09 | 9.82 | 19 | 396357 | 7025 | 52945665 |
Sinus node dysfunction | 14.08 | 9.82 | 67 | 396309 | 4294 | 52948396 |
Exercise tolerance decreased | 14.05 | 9.82 | 77 | 396299 | 5218 | 52947472 |
Renal tubular necrosis | 13.98 | 9.82 | 138 | 396238 | 11281 | 52941409 |
Congenital acrochordon | 13.97 | 9.82 | 8 | 396368 | 66 | 52952624 |
Skin induration | 13.92 | 9.82 | 53 | 396323 | 3077 | 52949613 |
Immune reconstitution inflammatory syndrome | 13.86 | 9.82 | 16 | 396360 | 6330 | 52946360 |
Pulmonary hypoplasia | 13.84 | 9.82 | 14 | 396362 | 289 | 52952401 |
Pericardial effusion | 13.83 | 9.82 | 282 | 396094 | 26996 | 52925694 |
Haemorrhage intracranial | 13.83 | 9.82 | 156 | 396220 | 13196 | 52939494 |
Restlessness | 13.79 | 9.82 | 289 | 396087 | 27798 | 52924892 |
Platelet aggregation decreased | 13.79 | 9.82 | 6 | 396370 | 25 | 52952665 |
Carcinoid tumour of the caecum | 13.79 | 9.82 | 6 | 396370 | 25 | 52952665 |
Arterial occlusive disease | 13.79 | 9.82 | 74 | 396302 | 4975 | 52947715 |
Temperature regulation disorder | 13.78 | 9.82 | 7 | 396369 | 4200 | 52948490 |
Lymphadenopathy | 13.77 | 9.82 | 188 | 396188 | 36067 | 52916623 |
Humerus fracture | 13.75 | 9.82 | 107 | 396269 | 8172 | 52944518 |
Normal newborn | 13.72 | 9.82 | 20 | 396356 | 7159 | 52945531 |
Norepinephrine increased | 13.68 | 9.82 | 8 | 396368 | 69 | 52952621 |
Internal haemorrhage | 13.63 | 9.82 | 70 | 396306 | 4626 | 52948064 |
Skin weeping | 13.61 | 9.82 | 15 | 396361 | 343 | 52952347 |
Breast cancer metastatic | 13.59 | 9.82 | 63 | 396313 | 15265 | 52937425 |
Congenital nail disorder | 13.56 | 9.82 | 9 | 396367 | 99 | 52952591 |
Wrong drug | 13.48 | 9.82 | 10 | 396366 | 133 | 52952557 |
Labelled drug-drug interaction medication error | 13.48 | 9.82 | 132 | 396244 | 10767 | 52941923 |
Gastrointestinal ischaemia | 13.46 | 9.82 | 12 | 396364 | 210 | 52952480 |
Oropharyngeal swelling | 13.43 | 9.82 | 24 | 396352 | 872 | 52951818 |
Joint stiffness | 13.39 | 9.82 | 152 | 396224 | 30131 | 52922559 |
Hypomania | 13.39 | 9.82 | 10 | 396366 | 4872 | 52947818 |
Cardiomegaly | 13.37 | 9.82 | 196 | 396180 | 17604 | 52935086 |
Hyperprolactinaemia | 13.36 | 9.82 | 4 | 396372 | 3311 | 52949379 |
Heat illness | 13.30 | 9.82 | 11 | 396365 | 173 | 52952517 |
Secondary hypertension | 13.30 | 9.82 | 10 | 396366 | 136 | 52952554 |
Microalbuminuria | 13.27 | 9.82 | 15 | 396361 | 353 | 52952337 |
Electrocardiogram U wave present | 13.26 | 9.82 | 9 | 396367 | 103 | 52952587 |
Stomatitis haemorrhagic | 13.26 | 9.82 | 6 | 396370 | 28 | 52952662 |
Bowel movement irregularity | 13.25 | 9.82 | 64 | 396312 | 4127 | 52948563 |
Vision blurred | 13.24 | 9.82 | 770 | 395606 | 84834 | 52867856 |
Candida infection | 13.17 | 9.82 | 122 | 396254 | 25151 | 52927539 |
Ischaemic cardiomyopathy | 13.15 | 9.82 | 46 | 396330 | 2562 | 52950128 |
Yellow skin | 12.98 | 9.82 | 41 | 396335 | 2165 | 52950525 |
Osteoporosis | 12.98 | 9.82 | 255 | 396121 | 46205 | 52906485 |
Device use error | 12.97 | 9.82 | 13 | 396363 | 5486 | 52947204 |
Jaundice hepatocellular | 12.93 | 9.82 | 6 | 396370 | 30 | 52952660 |
Femoral artery dissection | 12.93 | 9.82 | 6 | 396370 | 30 | 52952660 |
Venous aneurysm | 12.90 | 9.82 | 4 | 396372 | 4 | 52952686 |
Multiple-drug resistance | 12.86 | 9.82 | 4 | 396372 | 3231 | 52949459 |
Abnormal loss of weight | 12.86 | 9.82 | 76 | 396300 | 5296 | 52947394 |
Capillary disorder | 12.86 | 9.82 | 8 | 396368 | 78 | 52952612 |
Transplant rejection | 12.80 | 9.82 | 36 | 396340 | 10115 | 52942575 |
Finger deformity | 12.74 | 9.82 | 14 | 396362 | 5663 | 52947027 |
Psychogenic visual disorder | 12.73 | 9.82 | 5 | 396371 | 15 | 52952675 |
Renal aneurysm | 12.73 | 9.82 | 5 | 396371 | 15 | 52952675 |
Lung diffusion test abnormal | 12.69 | 9.82 | 8 | 396368 | 80 | 52952610 |
Kidney fibrosis | 12.62 | 9.82 | 34 | 396342 | 1641 | 52951049 |
Ventricular extrasystoles | 12.61 | 9.82 | 138 | 396238 | 11586 | 52941104 |
Hand dermatitis | 12.61 | 9.82 | 8 | 396368 | 81 | 52952609 |
Hypoacusis | 12.60 | 9.82 | 237 | 396139 | 22362 | 52930328 |
Deformity | 12.59 | 9.82 | 25 | 396351 | 7929 | 52944761 |
Coordination abnormal | 12.54 | 9.82 | 140 | 396236 | 11811 | 52940879 |
Sinus arrhythmia | 12.53 | 9.82 | 32 | 396344 | 1495 | 52951195 |
Blood cholinesterase increased | 12.49 | 9.82 | 5 | 396371 | 16 | 52952674 |
Intestinal ischaemia | 12.48 | 9.82 | 97 | 396279 | 7405 | 52945285 |
Fluid intake reduced | 12.46 | 9.82 | 55 | 396321 | 3414 | 52949276 |
Biopsy kidney | 12.43 | 9.82 | 9 | 396367 | 115 | 52952575 |
Acral lentiginous melanoma | 12.43 | 9.82 | 4 | 396372 | 5 | 52952685 |
Myelosuppression | 12.42 | 9.82 | 51 | 396325 | 12777 | 52939913 |
Duodenal ulcer repair | 12.40 | 9.82 | 7 | 396369 | 56 | 52952634 |
Aspergillus infection | 12.36 | 9.82 | 23 | 396353 | 7473 | 52945217 |
Atrial pressure increased | 12.27 | 9.82 | 5 | 396371 | 17 | 52952673 |
Bacteriuria | 12.25 | 9.82 | 21 | 396355 | 738 | 52951952 |
Adverse drug reaction | 12.21 | 9.82 | 304 | 396072 | 53321 | 52899369 |
Oxalosis | 12.19 | 9.82 | 6 | 396370 | 35 | 52952655 |
Renal transplant | 12.18 | 9.82 | 30 | 396346 | 1370 | 52951320 |
Drug-disease interaction | 12.17 | 9.82 | 14 | 396362 | 336 | 52952354 |
Femoral neck fracture | 12.12 | 9.82 | 105 | 396271 | 8278 | 52944412 |
Blood sodium increased | 12.12 | 9.82 | 46 | 396330 | 2666 | 52950024 |
Synovial cyst | 12.12 | 9.82 | 28 | 396348 | 8408 | 52944282 |
Thalamus haemorrhage | 12.10 | 9.82 | 19 | 396357 | 620 | 52952070 |
Inhibitory drug interaction | 12.08 | 9.82 | 41 | 396335 | 2249 | 52950441 |
Pigmentation disorder | 12.07 | 9.82 | 61 | 396315 | 4006 | 52948684 |
Acute respiratory failure | 12.07 | 9.82 | 311 | 396065 | 30947 | 52921743 |
Hyperparathyroidism secondary | 12.03 | 9.82 | 31 | 396345 | 1456 | 52951234 |
Product solubility abnormal | 12.03 | 9.82 | 23 | 396353 | 881 | 52951809 |
Hypereosinophilic syndrome | 11.98 | 9.82 | 13 | 396363 | 292 | 52952398 |
Ectopic pregnancy | 11.91 | 9.82 | 3 | 396373 | 2784 | 52949906 |
Enterochromaffin cell hyperplasia | 11.91 | 9.82 | 7 | 396369 | 61 | 52952629 |
Gingival pain | 11.90 | 9.82 | 86 | 396290 | 6417 | 52946273 |
Dysphagia | 11.90 | 9.82 | 753 | 395623 | 83644 | 52869046 |
Drug screen positive | 11.88 | 9.82 | 7 | 396369 | 3865 | 52948825 |
Bifascicular block | 11.87 | 9.82 | 9 | 396367 | 124 | 52952566 |
Neurosensory hypoacusis | 11.84 | 9.82 | 13 | 396363 | 296 | 52952394 |
Rheumatoid factor negative | 11.81 | 9.82 | 18 | 396358 | 572 | 52952118 |
Acne | 11.77 | 9.82 | 103 | 396273 | 21483 | 52931207 |
Coeliac disease | 11.75 | 9.82 | 30 | 396346 | 8705 | 52943985 |
Type 2 diabetes mellitus | 11.75 | 9.82 | 165 | 396211 | 31505 | 52921185 |
Typical aura without headache | 11.73 | 9.82 | 3 | 396373 | 0 | 52952690 |
Blood pressure difference of extremities | 11.73 | 9.82 | 3 | 396373 | 0 | 52952690 |
Tongue abscess | 11.73 | 9.82 | 3 | 396373 | 0 | 52952690 |
Carbohydrate metabolism disorder | 11.73 | 9.82 | 3 | 396373 | 0 | 52952690 |
Morganella test positive | 11.73 | 9.82 | 3 | 396373 | 0 | 52952690 |
Adrenal gland cancer metastatic | 11.73 | 9.82 | 3 | 396373 | 0 | 52952690 |
Cardiac index increased | 11.73 | 9.82 | 3 | 396373 | 0 | 52952690 |
Ventricular drainage | 11.73 | 9.82 | 3 | 396373 | 0 | 52952690 |
Tachypnoea | 11.68 | 9.82 | 174 | 396202 | 15680 | 52937010 |
Leukaemic infiltration renal | 11.65 | 9.82 | 5 | 396371 | 20 | 52952670 |
Gastric cancer | 11.64 | 9.82 | 52 | 396324 | 3245 | 52949445 |
Pernicious anaemia | 11.62 | 9.82 | 20 | 396356 | 705 | 52951985 |
Coronary arterial stent insertion | 11.61 | 9.82 | 47 | 396329 | 2807 | 52949883 |
Anti-erythropoietin antibody positive | 11.59 | 9.82 | 15 | 396361 | 408 | 52952282 |
Adrenal neoplasm | 11.56 | 9.82 | 13 | 396363 | 304 | 52952386 |
Cerebrovascular insufficiency | 11.54 | 9.82 | 8 | 396368 | 95 | 52952595 |
Influenza like illness | 11.54 | 9.82 | 354 | 396022 | 60505 | 52892185 |
Congenital diaphragmatic hernia | 11.52 | 9.82 | 11 | 396365 | 211 | 52952479 |
Bladder sphincter atony | 11.51 | 9.82 | 10 | 396366 | 169 | 52952521 |
Diffuse large B-cell lymphoma refractory | 11.50 | 9.82 | 25 | 396351 | 1051 | 52951639 |
Cerebral atrophy | 11.47 | 9.82 | 70 | 396306 | 4934 | 52947756 |
Retroperitoneal haematoma | 11.47 | 9.82 | 47 | 396329 | 2823 | 52949867 |
Cerebellar haemorrhage | 11.43 | 9.82 | 30 | 396346 | 1425 | 52951265 |
Brain stem infarction | 11.43 | 9.82 | 22 | 396354 | 847 | 52951843 |
Phrenic nerve paralysis | 11.41 | 9.82 | 6 | 396370 | 41 | 52952649 |
Rib deformity | 11.41 | 9.82 | 10 | 396366 | 171 | 52952519 |
Product administration error | 11.39 | 9.82 | 224 | 396152 | 21307 | 52931383 |
Joint injury | 11.38 | 9.82 | 107 | 396269 | 21993 | 52930697 |
Hypertonic bladder | 11.24 | 9.82 | 51 | 396325 | 3204 | 52949486 |
Embedded device | 11.22 | 9.82 | 5 | 396371 | 3236 | 52949454 |
Small for dates baby | 11.20 | 9.82 | 7 | 396369 | 3745 | 52948945 |
Tonsillar inflammation | 11.20 | 9.82 | 8 | 396368 | 100 | 52952590 |
Cerebrovascular disorder | 11.20 | 9.82 | 48 | 396328 | 2942 | 52949748 |
Hepatocellular carcinoma | 11.19 | 9.82 | 49 | 396327 | 3031 | 52949659 |
Hospice care | 11.18 | 9.82 | 81 | 396295 | 6049 | 52946641 |
Gastric pH increased | 11.18 | 9.82 | 6 | 396370 | 43 | 52952647 |
Renal function test abnormal | 11.13 | 9.82 | 50 | 396326 | 3127 | 52949563 |
Sensorimotor disorder | 11.13 | 9.82 | 16 | 396360 | 482 | 52952208 |
Oesophageal food impaction | 11.13 | 9.82 | 10 | 396366 | 177 | 52952513 |
Acquired porphyria | 11.11 | 9.82 | 5 | 396371 | 23 | 52952667 |
Porphyrins urine increased | 11.11 | 9.82 | 5 | 396371 | 23 | 52952667 |
Head banging | 11.10 | 9.82 | 15 | 396361 | 426 | 52952264 |
Sudden hearing loss | 11.07 | 9.82 | 27 | 396349 | 1225 | 52951465 |
Fluid overload | 11.07 | 9.82 | 278 | 396098 | 27553 | 52925137 |
Cytotoxic oedema | 11.02 | 9.82 | 9 | 396367 | 139 | 52952551 |
Vasculitis | 11.02 | 9.82 | 164 | 396212 | 14776 | 52937914 |
Mixed dementia | 10.99 | 9.82 | 4 | 396372 | 9 | 52952681 |
Rales | 10.97 | 9.82 | 126 | 396250 | 10706 | 52941984 |
Accelerated hypertension | 10.91 | 9.82 | 15 | 396361 | 433 | 52952257 |
Gingival disorder | 10.91 | 9.82 | 53 | 396323 | 3426 | 52949264 |
Essential hypertension | 10.88 | 9.82 | 67 | 396309 | 4738 | 52947952 |
Lethargy | 10.85 | 9.82 | 496 | 395880 | 53264 | 52899426 |
Muscular weakness | 10.79 | 9.82 | 881 | 395495 | 100111 | 52852579 |
Graft versus host disease | 10.75 | 9.82 | 23 | 396353 | 7099 | 52945591 |
Intestinal angioedema | 10.74 | 9.82 | 18 | 396358 | 621 | 52952069 |
Pneumonia viral | 10.71 | 9.82 | 23 | 396353 | 7089 | 52945601 |
Lip oedema | 10.63 | 9.82 | 54 | 396322 | 3553 | 52949137 |
Cardiac valve sclerosis | 10.62 | 9.82 | 5 | 396371 | 26 | 52952664 |
Dyslalia | 10.62 | 9.82 | 17 | 396359 | 564 | 52952126 |
Cell marker increased | 10.58 | 9.82 | 13 | 396363 | 335 | 52952355 |
Aortic stenosis | 10.57 | 9.82 | 64 | 396312 | 4499 | 52948191 |
Nephrotic syndrome | 10.55 | 9.82 | 72 | 396304 | 5273 | 52947417 |
Disease recurrence | 10.54 | 9.82 | 102 | 396274 | 20844 | 52931846 |
Ventricular internal diameter abnormal | 10.53 | 9.82 | 6 | 396370 | 49 | 52952641 |
Cholestatic liver injury | 10.49 | 9.82 | 41 | 396335 | 2410 | 52950280 |
Scleritis | 10.47 | 9.82 | 6 | 396370 | 3364 | 52949326 |
Acute graft versus host disease | 10.42 | 9.82 | 10 | 396366 | 4307 | 52948383 |
Forced vital capacity decreased | 10.41 | 9.82 | 24 | 396352 | 1050 | 52951640 |
Psychomotor retardation | 10.40 | 9.82 | 54 | 396322 | 3584 | 52949106 |
Blood lactic acid | 10.39 | 9.82 | 8 | 396368 | 113 | 52952577 |
Respiratory tract infection | 10.33 | 9.82 | 179 | 396197 | 33045 | 52919645 |
Oesophageal carcinoma recurrent | 10.32 | 9.82 | 5 | 396371 | 28 | 52952662 |
Neurofibrosarcoma | 10.31 | 9.82 | 9 | 396367 | 153 | 52952537 |
Hyperhidrosis | 10.31 | 9.82 | 601 | 395775 | 96192 | 52856498 |
Renal cyst infection | 10.27 | 9.82 | 8 | 396368 | 115 | 52952575 |
Infusion site streaking | 10.27 | 9.82 | 14 | 396362 | 401 | 52952289 |
Pneumothorax traumatic | 10.26 | 9.82 | 9 | 396367 | 154 | 52952536 |
Skin necrosis | 10.26 | 9.82 | 42 | 396334 | 10530 | 52942160 |
Tracheo-oesophageal fistula | 10.23 | 9.82 | 17 | 396359 | 582 | 52952108 |
Small cell carcinoma | 10.22 | 9.82 | 10 | 396366 | 198 | 52952492 |
Congenital uterine anomaly | 10.21 | 9.82 | 8 | 396368 | 116 | 52952574 |
Transplant dysfunction | 10.20 | 9.82 | 13 | 396363 | 4925 | 52947765 |
Orthopnoea | 10.20 | 9.82 | 79 | 396297 | 6025 | 52946665 |
Nephropathy | 10.13 | 9.82 | 72 | 396304 | 5345 | 52947345 |
Myoglobin blood increased | 10.12 | 9.82 | 29 | 396347 | 1451 | 52951239 |
Tuberculosis | 10.12 | 9.82 | 45 | 396331 | 11026 | 52941664 |
Carcinoid tumour of the stomach | 10.07 | 9.82 | 9 | 396367 | 158 | 52952532 |
Porphyrins stool increased | 10.04 | 9.82 | 5 | 396371 | 30 | 52952660 |
Blood chloride decreased | 10.04 | 9.82 | 73 | 396303 | 5458 | 52947232 |
Mesenteric arterial occlusion | 10.04 | 9.82 | 7 | 396369 | 84 | 52952606 |
Hyperparathyroidism primary | 10.00 | 9.82 | 13 | 396363 | 355 | 52952335 |
Injection site induration | 9.99 | 9.82 | 32 | 396344 | 8626 | 52944064 |
Incorrect route of product administration | 9.98 | 9.82 | 93 | 396283 | 19151 | 52933539 |
Iliac artery occlusion | 9.98 | 9.82 | 9 | 396367 | 160 | 52952530 |
Pelvic pain | 9.98 | 9.82 | 52 | 396324 | 12221 | 52940469 |
Therapeutic drug monitoring analysis not performed | 9.97 | 9.82 | 19 | 396357 | 726 | 52951964 |
Urine flow decreased | 9.96 | 9.82 | 11 | 396365 | 252 | 52952438 |
Malignant hypertension | 9.94 | 9.82 | 24 | 396352 | 1082 | 52951608 |
Trichoglossia | 9.94 | 9.82 | 10 | 396366 | 205 | 52952485 |
Skin infection | 9.93 | 9.82 | 55 | 396321 | 12727 | 52939963 |
Interstitial granulomatous dermatitis | 9.91 | 9.82 | 5 | 396371 | 31 | 52952659 |
Fibrosis | 9.90 | 9.82 | 57 | 396319 | 3935 | 52948755 |
Adams-Stokes syndrome | 9.86 | 9.82 | 6 | 396370 | 56 | 52952634 |
End stage renal disease | 9.83 | 9.82 | 79 | 396297 | 6092 | 52946598 |
Gastric cyst | 9.83 | 9.82 | 8 | 396368 | 123 | 52952567 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 556.36 | 11.26 | 2100 | 320938 | 90417 | 32100071 |
Gingival hypertrophy | 395.55 | 11.26 | 233 | 322805 | 1466 | 32189022 |
Drug abuse | 336.78 | 11.26 | 189 | 322849 | 80054 | 32110434 |
Drug ineffective | 280.68 | 11.26 | 2451 | 320587 | 381026 | 31809462 |
Blood pressure inadequately controlled | 276.68 | 11.26 | 224 | 322814 | 2498 | 32187990 |
Hypertension | 267.25 | 11.26 | 2228 | 320810 | 129522 | 32060966 |
Off label use | 265.30 | 11.26 | 1869 | 321169 | 304451 | 31886037 |
Shock | 197.08 | 11.26 | 607 | 322431 | 23507 | 32166981 |
Hypertensive crisis | 192.72 | 11.26 | 328 | 322710 | 8489 | 32181999 |
Intentional overdose | 178.64 | 11.26 | 853 | 322185 | 40748 | 32149740 |
Foetal exposure during pregnancy | 177.97 | 11.26 | 94 | 322944 | 41207 | 32149281 |
Neutropenia | 175.39 | 11.26 | 771 | 322267 | 141404 | 32049084 |
Oedema peripheral | 170.82 | 11.26 | 1809 | 321229 | 112282 | 32078206 |
Death | 163.82 | 11.26 | 2746 | 320292 | 379771 | 31810717 |
Angioedema | 160.12 | 11.26 | 750 | 322288 | 35539 | 32154949 |
Acute kidney injury | 157.51 | 11.26 | 3920 | 319118 | 289548 | 31900940 |
Febrile neutropenia | 153.81 | 11.26 | 638 | 322400 | 118928 | 32071560 |
Product use in unapproved indication | 151.48 | 11.26 | 408 | 322630 | 86796 | 32103692 |
Blood pressure increased | 151.20 | 11.26 | 1324 | 321714 | 78030 | 32112458 |
Bradycardia | 144.21 | 11.26 | 1209 | 321829 | 70353 | 32120135 |
Hypotension | 140.43 | 11.26 | 2966 | 320072 | 213144 | 31977344 |
Non-cardiogenic pulmonary oedema | 139.19 | 11.26 | 86 | 322952 | 597 | 32189891 |
Treatment failure | 139.00 | 11.26 | 111 | 322927 | 39052 | 32151436 |
Cerebral infarction | 118.36 | 11.26 | 566 | 322472 | 27048 | 32163440 |
Syncope | 116.19 | 11.26 | 1388 | 321650 | 88736 | 32101752 |
Angina pectoris | 100.38 | 11.26 | 594 | 322444 | 30832 | 32159656 |
Rheumatoid arthritis | 98.06 | 11.26 | 183 | 322855 | 44361 | 32146127 |
Distributive shock | 94.48 | 11.26 | 76 | 322962 | 839 | 32189649 |
Hypokalaemia | 89.68 | 11.26 | 889 | 322149 | 54205 | 32136283 |
Blood creatinine increased | 85.47 | 11.26 | 1386 | 321652 | 94746 | 32095742 |
Hyperkalaemia | 85.41 | 11.26 | 1064 | 321974 | 68686 | 32121802 |
Drug resistance | 82.85 | 11.26 | 64 | 322974 | 22901 | 32167587 |
Thrombocytopenia | 81.21 | 11.26 | 1013 | 322025 | 147286 | 32043202 |
Metabolic acidosis | 81.08 | 11.26 | 686 | 322352 | 40013 | 32150475 |
Cerebrovascular accident | 79.15 | 11.26 | 1251 | 321787 | 85069 | 32105419 |
Swollen tongue | 77.18 | 11.26 | 304 | 322734 | 13335 | 32177153 |
Drug dependence | 75.54 | 11.26 | 73 | 322965 | 23411 | 32167077 |
Premature baby | 74.25 | 11.26 | 46 | 322992 | 18472 | 32172016 |
Lip swelling | 74.04 | 11.26 | 302 | 322736 | 13463 | 32177025 |
Immune reconstitution inflammatory syndrome | 72.42 | 11.26 | 6 | 323032 | 9553 | 32180935 |
Blood pressure systolic increased | 71.26 | 11.26 | 352 | 322686 | 17044 | 32173444 |
Pyrexia | 70.35 | 11.26 | 2537 | 320501 | 317431 | 31873057 |
Rhabdomyolysis | 69.88 | 11.26 | 996 | 322042 | 66269 | 32124219 |
Renal impairment | 69.49 | 11.26 | 1292 | 321746 | 90680 | 32099808 |
Pancytopenia | 69.45 | 11.26 | 576 | 322462 | 90659 | 32099829 |
Sepsis | 68.66 | 11.26 | 1137 | 321901 | 157697 | 32032791 |
Aggression | 65.58 | 11.26 | 188 | 322850 | 39201 | 32151287 |
Pathogen resistance | 64.34 | 11.26 | 9 | 323029 | 9501 | 32180987 |
Dizziness | 61.73 | 11.26 | 2608 | 320430 | 207010 | 31983478 |
Infusion related reaction | 59.37 | 11.26 | 242 | 322796 | 45357 | 32145131 |
Infective pulmonary exacerbation of cystic fibrosis | 57.79 | 11.26 | 9 | 323029 | 8770 | 32181718 |
Chronic kidney disease | 57.45 | 11.26 | 629 | 322409 | 39346 | 32151142 |
Seizure | 57.33 | 11.26 | 708 | 322330 | 103146 | 32087342 |
Suspected suicide | 56.34 | 11.26 | 105 | 322933 | 2923 | 32187565 |
Exposure during pregnancy | 53.31 | 11.26 | 13 | 323025 | 9216 | 32181272 |
Mucosal inflammation | 53.18 | 11.26 | 163 | 322875 | 33271 | 32157217 |
Interstitial lung disease | 51.13 | 11.26 | 919 | 322119 | 64082 | 32126406 |
Leukopenia | 50.68 | 11.26 | 369 | 322669 | 59753 | 32130735 |
Septic shock | 50.49 | 11.26 | 440 | 322598 | 68549 | 32121939 |
Multiple organ dysfunction syndrome | 50.03 | 11.26 | 448 | 322590 | 69406 | 32121082 |
Agitation | 49.84 | 11.26 | 348 | 322690 | 56888 | 32133600 |
Lactic acidosis | 49.72 | 11.26 | 531 | 322507 | 33005 | 32157483 |
Product use issue | 49.42 | 11.26 | 314 | 322724 | 52463 | 32138025 |
Glycosylated haemoglobin increased | 48.98 | 11.26 | 219 | 322819 | 10170 | 32180318 |
Chronic pigmented purpura | 47.39 | 11.26 | 23 | 323015 | 91 | 32190397 |
Progressive multifocal leukoencephalopathy | 46.82 | 11.26 | 18 | 323020 | 9513 | 32180975 |
Suicide attempt | 46.61 | 11.26 | 583 | 322455 | 37661 | 32152827 |
Renal artery stenosis | 46.38 | 11.26 | 75 | 322963 | 1858 | 32188630 |
Cardiac failure congestive | 46.29 | 11.26 | 1137 | 321901 | 83715 | 32106773 |
Pemphigoid | 45.30 | 11.26 | 185 | 322853 | 8251 | 32182237 |
Depression | 44.83 | 11.26 | 686 | 322352 | 96374 | 32094114 |
Palmar-plantar erythrodysaesthesia syndrome | 44.81 | 11.26 | 289 | 322749 | 15460 | 32175028 |
Nephrotic syndrome | 43.62 | 11.26 | 166 | 322872 | 7163 | 32183325 |
Cytokine release syndrome | 43.61 | 11.26 | 42 | 322996 | 13493 | 32176995 |
Acute graft versus host disease | 43.16 | 11.26 | 6 | 323032 | 6364 | 32184124 |
Proteinuria | 43.13 | 11.26 | 308 | 322730 | 17047 | 32173441 |
Abnormal behaviour | 42.83 | 11.26 | 128 | 322910 | 26338 | 32164150 |
Myalgia | 41.22 | 11.26 | 1078 | 321960 | 80152 | 32110336 |
Aspergillus infection | 40.81 | 11.26 | 33 | 323005 | 11541 | 32178947 |
Infection | 40.06 | 11.26 | 596 | 322442 | 84119 | 32106369 |
Pulmonary oedema | 39.56 | 11.26 | 663 | 322375 | 45604 | 32144884 |
Suicidal ideation | 39.12 | 11.26 | 220 | 322818 | 37863 | 32152625 |
Gingival swelling | 37.96 | 11.26 | 55 | 322983 | 1234 | 32189254 |
Haemophagocytic lymphohistiocytosis | 37.91 | 11.26 | 34 | 323004 | 11301 | 32179187 |
Myocardial depression | 37.76 | 11.26 | 16 | 323022 | 42 | 32190446 |
Sedation | 37.42 | 11.26 | 80 | 322958 | 18446 | 32172042 |
Atrioventricular block complete | 37.35 | 11.26 | 182 | 322856 | 8762 | 32181726 |
Synovitis | 37.14 | 11.26 | 32 | 323006 | 10846 | 32179642 |
Bronchopulmonary aspergillosis | 36.98 | 11.26 | 49 | 322989 | 13638 | 32176850 |
5-hydroxyindolacetic acid in urine increased | 36.90 | 11.26 | 25 | 323013 | 207 | 32190281 |
Cytomegalovirus infection | 36.46 | 11.26 | 130 | 322908 | 25334 | 32165154 |
Hypoglycaemia | 36.33 | 11.26 | 750 | 322288 | 53632 | 32136856 |
Bone marrow failure | 36.13 | 11.26 | 167 | 322871 | 30237 | 32160251 |
Vasoplegia syndrome | 35.69 | 11.26 | 57 | 322981 | 1397 | 32189091 |
Plasma cell myeloma | 35.57 | 11.26 | 383 | 322655 | 57231 | 32133257 |
Thalamus haemorrhage | 35.50 | 11.26 | 47 | 322991 | 966 | 32189522 |
Gastrointestinal tract mucosal pigmentation | 34.85 | 11.26 | 29 | 323009 | 337 | 32190151 |
Hypomagnesaemia | 34.84 | 11.26 | 312 | 322726 | 18493 | 32171995 |
Diabetic nephropathy | 34.25 | 11.26 | 70 | 322968 | 2089 | 32188399 |
Peripheral swelling | 34.08 | 11.26 | 905 | 322133 | 67440 | 32123048 |
Gingival bleeding | 33.54 | 11.26 | 148 | 322890 | 6833 | 32183655 |
Tachycardia | 33.51 | 11.26 | 568 | 322470 | 78520 | 32111968 |
Diastolic dysfunction | 33.33 | 11.26 | 121 | 322917 | 5103 | 32185385 |
Psychotic disorder | 33.31 | 11.26 | 117 | 322921 | 22903 | 32167585 |
Graft versus host disease | 33.14 | 11.26 | 35 | 323003 | 10771 | 32179717 |
Transient ischaemic attack | 32.63 | 11.26 | 396 | 322642 | 25398 | 32165090 |
Drug ineffective for unapproved indication | 32.55 | 11.26 | 55 | 322983 | 13857 | 32176631 |
Myelosuppression | 32.37 | 11.26 | 41 | 322997 | 11635 | 32178853 |
Febrile bone marrow aplasia | 32.24 | 11.26 | 22 | 323016 | 8393 | 32182095 |
Nocturia | 31.83 | 11.26 | 179 | 322859 | 9115 | 32181373 |
Dyskinesia | 31.51 | 11.26 | 124 | 322914 | 23479 | 32167009 |
Pseudolymphoma | 31.31 | 11.26 | 33 | 323005 | 527 | 32189961 |
Orthostatic hypotension | 31.24 | 11.26 | 391 | 322647 | 25259 | 32165229 |
C-reactive protein abnormal | 31.23 | 11.26 | 12 | 323026 | 6344 | 32184144 |
Injection site pain | 30.77 | 11.26 | 197 | 322841 | 32861 | 32157627 |
Palpitations | 30.59 | 11.26 | 515 | 322523 | 35454 | 32155034 |
Chronic graft versus host disease | 30.51 | 11.26 | 4 | 323034 | 4436 | 32186052 |
Drug withdrawal syndrome | 30.51 | 11.26 | 101 | 322937 | 20130 | 32170358 |
Post transplant lymphoproliferative disorder | 30.40 | 11.26 | 10 | 323028 | 5824 | 32184664 |
Hyponatraemia | 30.11 | 11.26 | 961 | 322077 | 73552 | 32116936 |
Staphylococcal infection | 29.34 | 11.26 | 195 | 322843 | 32244 | 32158244 |
Renal cell carcinoma | 29.01 | 11.26 | 127 | 322911 | 5843 | 32184645 |
Mucormycosis | 28.92 | 11.26 | 10 | 323028 | 5644 | 32184844 |
Dermatomyositis | 28.90 | 11.26 | 47 | 322991 | 1170 | 32189318 |
Psoriatic arthropathy | 28.45 | 11.26 | 87 | 322951 | 17773 | 32172715 |
Sinus bradycardia | 28.41 | 11.26 | 223 | 322815 | 12715 | 32177773 |
Haematotoxicity | 28.34 | 11.26 | 16 | 323022 | 6760 | 32183728 |
Contraindicated product administered | 28.24 | 11.26 | 96 | 322942 | 18980 | 32171508 |
Myelodysplastic syndrome | 28.22 | 11.26 | 103 | 322935 | 19935 | 32170553 |
Periodontitis | 28.03 | 11.26 | 60 | 322978 | 1851 | 32188637 |
Substance abuse | 28.01 | 11.26 | 18 | 323020 | 7089 | 32183399 |
Acute hepatic failure | 27.90 | 11.26 | 54 | 322984 | 12915 | 32177573 |
Candida infection | 27.38 | 11.26 | 81 | 322957 | 16722 | 32173766 |
Sinusitis | 27.26 | 11.26 | 232 | 322806 | 36328 | 32154160 |
Pelvic mass | 26.96 | 11.26 | 20 | 323018 | 194 | 32190294 |
Multiple-drug resistance | 26.93 | 11.26 | 3 | 323035 | 3772 | 32186716 |
Vertebral osteophyte | 26.87 | 11.26 | 13 | 323025 | 51 | 32190437 |
Polymyositis | 26.50 | 11.26 | 51 | 322987 | 1455 | 32189033 |
Plasmapheresis | 26.49 | 11.26 | 25 | 323013 | 347 | 32190141 |
Electrocardiogram QRS complex prolonged | 25.91 | 11.26 | 102 | 322936 | 4472 | 32186016 |
Intentional product use issue | 25.89 | 11.26 | 281 | 322757 | 41930 | 32148558 |
Loss of consciousness | 25.85 | 11.26 | 1036 | 322002 | 81671 | 32108817 |
Primary hyperaldosteronism | 25.76 | 11.26 | 13 | 323025 | 57 | 32190431 |
Accelerated hypertension | 25.66 | 11.26 | 21 | 323017 | 238 | 32190250 |
Atrioventricular block first degree | 25.62 | 11.26 | 120 | 322918 | 5683 | 32184805 |
Cytomegalovirus chorioretinitis | 25.44 | 11.26 | 3 | 323035 | 3609 | 32186879 |
Blood mercury abnormal | 25.30 | 11.26 | 19 | 323019 | 188 | 32190300 |
Stenosis | 25.26 | 11.26 | 41 | 322997 | 1019 | 32189469 |
Myocardial infarction | 25.16 | 11.26 | 1507 | 321531 | 124169 | 32066319 |
Device issue | 25.02 | 11.26 | 31 | 323007 | 8881 | 32181607 |
Dystonia | 24.85 | 11.26 | 42 | 322996 | 10581 | 32179907 |
Coronary artery disease | 24.72 | 11.26 | 658 | 322380 | 49048 | 32141440 |
Neutrophil count decreased | 24.63 | 11.26 | 325 | 322713 | 46814 | 32143674 |
No adverse event | 24.51 | 11.26 | 109 | 322929 | 19944 | 32170544 |
Erectile dysfunction | 24.41 | 11.26 | 303 | 322735 | 19536 | 32170952 |
Multiple sclerosis | 24.30 | 11.26 | 24 | 323014 | 7620 | 32182868 |
Respiratory depression | 24.30 | 11.26 | 60 | 322978 | 13151 | 32177337 |
Hyperdynamic left ventricle | 24.29 | 11.26 | 14 | 323024 | 84 | 32190404 |
Diabetes mellitus inadequate control | 24.27 | 11.26 | 226 | 322812 | 13542 | 32176946 |
Wrong technique in product usage process | 24.15 | 11.26 | 227 | 322811 | 34832 | 32155656 |
Product monitoring error | 24.08 | 11.26 | 68 | 322970 | 2506 | 32187982 |
Lipodystrophy acquired | 23.73 | 11.26 | 4 | 323034 | 3678 | 32186810 |
Disease progression | 23.71 | 11.26 | 669 | 322369 | 86193 | 32104295 |
Orbital myositis | 23.66 | 11.26 | 16 | 323022 | 132 | 32190356 |
Akathisia | 23.58 | 11.26 | 21 | 323017 | 7004 | 32183484 |
Eczema | 23.52 | 11.26 | 240 | 322798 | 14740 | 32175748 |
Irritability | 23.42 | 11.26 | 146 | 322892 | 24508 | 32165980 |
Renal failure | 23.18 | 11.26 | 1592 | 321446 | 132886 | 32057602 |
Pneumonia | 23.17 | 11.26 | 3135 | 319903 | 352117 | 31838371 |
Carotid sinus syndrome | 23.14 | 11.26 | 10 | 323028 | 28 | 32190460 |
Acute myocardial infarction | 22.99 | 11.26 | 714 | 322324 | 54435 | 32136053 |
Prerenal failure | 22.98 | 11.26 | 58 | 322980 | 1997 | 32188491 |
Hospitalisation | 22.97 | 11.26 | 345 | 322693 | 48626 | 32141862 |
Adenovirus infection | 22.91 | 11.26 | 9 | 323029 | 4695 | 32185793 |
Maternal drugs affecting foetus | 22.87 | 11.26 | 7 | 323031 | 4270 | 32186218 |
Aortic dissection | 22.85 | 11.26 | 67 | 322971 | 2523 | 32187965 |
Tongue oedema | 22.82 | 11.26 | 72 | 322966 | 2824 | 32187664 |
Hyperplasia | 22.79 | 11.26 | 30 | 323008 | 613 | 32189875 |
Atrioventricular block | 22.72 | 11.26 | 142 | 322896 | 7513 | 32182975 |
Venoocclusive liver disease | 22.42 | 11.26 | 24 | 323014 | 7341 | 32183147 |
Hypertensive nephropathy | 22.39 | 11.26 | 26 | 323012 | 465 | 32190023 |
Hyperuricaemia | 22.31 | 11.26 | 148 | 322890 | 7993 | 32182495 |
Diffuse large B-cell lymphoma | 22.15 | 11.26 | 31 | 323007 | 8431 | 32182057 |
Pseudomonas infection | 21.98 | 11.26 | 55 | 322983 | 12001 | 32178487 |
Chills | 21.93 | 11.26 | 599 | 322439 | 77485 | 32113003 |
Clear cell renal cell carcinoma | 21.66 | 11.26 | 38 | 323000 | 1008 | 32189480 |
Lacunar infarction | 21.35 | 11.26 | 75 | 322963 | 3111 | 32187377 |
Brain stem infarction | 21.34 | 11.26 | 43 | 322995 | 1270 | 32189218 |
Embolic stroke | 21.25 | 11.26 | 84 | 322954 | 3690 | 32186798 |
Melaena | 21.18 | 11.26 | 472 | 322566 | 34193 | 32156295 |
Osteonecrosis | 21.14 | 11.26 | 89 | 322949 | 16533 | 32173955 |
Heart rate decreased | 21.13 | 11.26 | 360 | 322678 | 24840 | 32165648 |
Schizophrenia | 21.11 | 11.26 | 42 | 322996 | 9942 | 32180546 |
Coma | 21.10 | 11.26 | 297 | 322741 | 42315 | 32148173 |
Alcohol abuse | 21.06 | 11.26 | 9 | 323029 | 4463 | 32186025 |
Disease recurrence | 21.06 | 11.26 | 85 | 322953 | 15979 | 32174509 |
Carotid arteriosclerosis | 20.96 | 11.26 | 38 | 323000 | 1035 | 32189453 |
Status epilepticus | 20.95 | 11.26 | 56 | 322982 | 11950 | 32178538 |
Hypertensive heart disease | 20.91 | 11.26 | 63 | 322975 | 2409 | 32188079 |
Renal disorder | 20.84 | 11.26 | 359 | 322679 | 24824 | 32165664 |
Carotid artery stenosis | 20.82 | 11.26 | 100 | 322938 | 4786 | 32185702 |
Leukaemoid reaction | 20.72 | 11.26 | 13 | 323025 | 93 | 32190395 |
Lymphadenopathy | 20.57 | 11.26 | 171 | 322867 | 26911 | 32163577 |
Arthropathy | 20.43 | 11.26 | 135 | 322903 | 22354 | 32168134 |
Ventricular septal defect | 20.36 | 11.26 | 6 | 323032 | 3751 | 32186737 |
Atheroembolism | 20.32 | 11.26 | 18 | 323020 | 229 | 32190259 |
Vomiting | 20.30 | 11.26 | 2040 | 320998 | 233517 | 31956971 |
Brain contusion | 20.28 | 11.26 | 33 | 323005 | 822 | 32189666 |
Neurotoxicity | 20.23 | 11.26 | 79 | 322959 | 14991 | 32175497 |
Therapeutic product effect decreased | 20.03 | 11.26 | 204 | 322834 | 30813 | 32159675 |
Angina unstable | 19.91 | 11.26 | 199 | 322839 | 12156 | 32178332 |
Dyspnoea exertional | 19.73 | 11.26 | 517 | 322521 | 38444 | 32152044 |
Overdose | 19.71 | 11.26 | 1056 | 321982 | 86021 | 32104467 |
Acute myeloid leukaemia | 19.56 | 11.26 | 111 | 322927 | 19063 | 32171425 |
Macroglossia | 19.56 | 11.26 | 21 | 323017 | 343 | 32190145 |
Pain | 19.53 | 11.26 | 1601 | 321437 | 185955 | 32004533 |
Therapeutic product effect incomplete | 19.47 | 11.26 | 291 | 322747 | 41050 | 32149438 |
Haemorrhage subcutaneous | 19.32 | 11.26 | 60 | 322978 | 2333 | 32188155 |
Pericardial haemorrhage | 19.28 | 11.26 | 71 | 322967 | 3015 | 32187473 |
Blood pressure diastolic decreased | 19.22 | 11.26 | 130 | 322908 | 7067 | 32183421 |
Intentional self-injury | 19.21 | 11.26 | 72 | 322966 | 13828 | 32176660 |
Apparent death | 19.18 | 11.26 | 6 | 323032 | 3609 | 32186879 |
Graft versus host disease in skin | 19.09 | 11.26 | 6 | 323032 | 3598 | 32186890 |
Cytomegalovirus infection reactivation | 19.05 | 11.26 | 5 | 323033 | 3374 | 32187114 |
Skin toxicity | 19.01 | 11.26 | 7 | 323031 | 3799 | 32186689 |
Hepatic failure | 19.00 | 11.26 | 245 | 322793 | 35435 | 32155053 |
Acute coronary syndrome | 18.94 | 11.26 | 217 | 322821 | 13724 | 32176764 |
Ischaemic stroke | 18.93 | 11.26 | 262 | 322776 | 17314 | 32173174 |
Peripheral arterial occlusive disease | 18.92 | 11.26 | 109 | 322929 | 5600 | 32184888 |
Eyelid oedema | 18.87 | 11.26 | 103 | 322935 | 5186 | 32185302 |
Hydronephrosis | 18.68 | 11.26 | 160 | 322878 | 9363 | 32181125 |
Lymphocele | 18.58 | 11.26 | 44 | 322994 | 1454 | 32189034 |
Blood creatine phosphokinase increased | 18.49 | 11.26 | 587 | 322451 | 44889 | 32145599 |
Immune-mediated myositis | 18.44 | 11.26 | 47 | 322991 | 1628 | 32188860 |
Mouth swelling | 18.38 | 11.26 | 48 | 322990 | 1688 | 32188800 |
Condition aggravated | 18.36 | 11.26 | 1315 | 321723 | 154346 | 32036142 |
Epiglottic oedema | 18.12 | 11.26 | 15 | 323023 | 173 | 32190315 |
Fungal infection | 18.00 | 11.26 | 84 | 322954 | 15171 | 32175317 |
Duodenal ulcer haemorrhage | 17.84 | 11.26 | 97 | 322941 | 4877 | 32185611 |
Product substitution issue | 17.75 | 11.26 | 170 | 322868 | 10266 | 32180222 |
Dysphagia | 17.67 | 11.26 | 470 | 322568 | 61006 | 32129482 |
Hypersensitivity vasculitis | 17.65 | 11.26 | 78 | 322960 | 3603 | 32186885 |
Paranoia | 17.63 | 11.26 | 52 | 322986 | 10747 | 32179741 |
Cardiogenic shock | 17.62 | 11.26 | 296 | 322742 | 20366 | 32170122 |
Left ventricular hypertrophy | 17.62 | 11.26 | 123 | 322915 | 6757 | 32183731 |
Bone erosion | 17.60 | 11.26 | 3 | 323035 | 2736 | 32187752 |
Encephalopathy | 17.60 | 11.26 | 237 | 322801 | 34020 | 32156468 |
Neuropathy peripheral | 17.58 | 11.26 | 607 | 322431 | 76375 | 32114113 |
Mydriasis | 17.49 | 11.26 | 23 | 323015 | 6423 | 32184065 |
Zoonotic bacterial infection | 17.49 | 11.26 | 10 | 323028 | 59 | 32190429 |
Obsessive-compulsive disorder | 17.48 | 11.26 | 14 | 323024 | 4920 | 32185568 |
Presyncope | 17.47 | 11.26 | 255 | 322783 | 17046 | 32173442 |
Ear infection | 17.46 | 11.26 | 36 | 323002 | 8412 | 32182076 |
Neuroleptic malignant syndrome | 17.46 | 11.26 | 102 | 322936 | 17393 | 32173095 |
Blood pressure abnormal | 17.39 | 11.26 | 132 | 322906 | 7448 | 32183040 |
Putamen haemorrhage | 17.29 | 11.26 | 17 | 323021 | 249 | 32190239 |
Breath sounds abnormal | 17.24 | 11.26 | 111 | 322927 | 5934 | 32184554 |
Colitis ulcerative | 17.24 | 11.26 | 99 | 322939 | 16952 | 32173536 |
Maternal exposure during pregnancy | 17.22 | 11.26 | 11 | 323027 | 4346 | 32186142 |
Blood glucose increased | 17.20 | 11.26 | 803 | 322235 | 64438 | 32126050 |
Lung diffusion test decreased | 17.10 | 11.26 | 27 | 323011 | 655 | 32189833 |
Fibrillary glomerulonephritis | 17.07 | 11.26 | 9 | 323029 | 44 | 32190444 |
Deep vein thrombosis | 17.06 | 11.26 | 492 | 322546 | 63221 | 32127267 |
Pulmonary embolism | 17.01 | 11.26 | 669 | 322369 | 82990 | 32107498 |
Tremor | 16.95 | 11.26 | 648 | 322390 | 80629 | 32109859 |
Blood uric acid increased | 16.91 | 11.26 | 118 | 322920 | 6481 | 32184007 |
Osteoporosis | 16.90 | 11.26 | 63 | 322975 | 12119 | 32178369 |
Cognitive disorder | 16.85 | 11.26 | 170 | 322868 | 25724 | 32164764 |
Chest pain | 16.80 | 11.26 | 1442 | 321596 | 122695 | 32067793 |
Muscle rigidity | 16.76 | 11.26 | 56 | 322982 | 11130 | 32179358 |
Prescription drug used without a prescription | 16.72 | 11.26 | 39 | 322999 | 1276 | 32189212 |
Hepatic neoplasm | 16.68 | 11.26 | 52 | 322986 | 2026 | 32188462 |
Product dose omission issue | 16.61 | 11.26 | 841 | 322197 | 101734 | 32088754 |
Retinopathy hypertensive | 16.60 | 11.26 | 17 | 323021 | 262 | 32190226 |
Gout | 16.60 | 11.26 | 270 | 322768 | 18458 | 32172030 |
Diffuse large B-cell lymphoma recurrent | 16.57 | 11.26 | 3 | 323035 | 2619 | 32187869 |
Fall | 16.55 | 11.26 | 2208 | 320830 | 193993 | 31996495 |
Guillain-Barre syndrome | 16.53 | 11.26 | 102 | 322936 | 5372 | 32185116 |
Cerebral haemorrhage | 16.43 | 11.26 | 457 | 322581 | 34290 | 32156198 |
Drug intolerance | 16.35 | 11.26 | 377 | 322661 | 49858 | 32140630 |
Hyperbilirubinaemia | 16.32 | 11.26 | 106 | 322932 | 17624 | 32172864 |
Milk-alkali syndrome | 16.32 | 11.26 | 24 | 323014 | 546 | 32189942 |
Cytomegalovirus viraemia | 16.29 | 11.26 | 26 | 323012 | 6701 | 32183787 |
Left ventricular enlargement | 16.29 | 11.26 | 26 | 323012 | 637 | 32189851 |
Somnolence | 16.24 | 11.26 | 854 | 322184 | 102943 | 32087545 |
Metastatic renal cell carcinoma | 16.23 | 11.26 | 59 | 322979 | 2490 | 32187998 |
Intentional product misuse | 16.22 | 11.26 | 256 | 322782 | 35795 | 32154693 |
Thrombotic stroke | 16.15 | 11.26 | 17 | 323021 | 271 | 32190217 |
Dermatitis infected | 16.12 | 11.26 | 12 | 323026 | 117 | 32190371 |
Drug use disorder | 15.95 | 11.26 | 8 | 323030 | 3613 | 32186875 |
Swelling face | 15.89 | 11.26 | 313 | 322725 | 22192 | 32168296 |
Tenosynovitis | 15.87 | 11.26 | 9 | 323029 | 3794 | 32186694 |
Polymyalgia rheumatica | 15.87 | 11.26 | 38 | 323000 | 1265 | 32189223 |
Lacrimal disorder | 15.84 | 11.26 | 18 | 323020 | 314 | 32190174 |
Nipple inflammation | 15.78 | 11.26 | 10 | 323028 | 73 | 32190415 |
Hallucination | 15.73 | 11.26 | 400 | 322638 | 52219 | 32138269 |
Small for dates baby | 15.71 | 11.26 | 7 | 323031 | 3386 | 32187102 |
Epstein-Barr virus infection | 15.71 | 11.26 | 29 | 323009 | 7061 | 32183427 |
Liver carcinoma ruptured | 15.63 | 11.26 | 13 | 323025 | 151 | 32190337 |
Microalbuminuria | 15.56 | 11.26 | 27 | 323011 | 710 | 32189778 |
Lymphoma | 15.55 | 11.26 | 55 | 322983 | 10745 | 32179743 |
Blood pressure decreased | 15.53 | 11.26 | 638 | 322400 | 50442 | 32140046 |
Hyperammonaemia | 15.49 | 11.26 | 22 | 323016 | 5947 | 32184541 |
Hypertensive emergency | 15.42 | 11.26 | 30 | 323008 | 863 | 32189625 |
Drug eruption | 15.42 | 11.26 | 272 | 322766 | 18894 | 32171594 |
Aortic aneurysm | 15.41 | 11.26 | 117 | 322921 | 6602 | 32183886 |
Pharyngeal oedema | 15.40 | 11.26 | 114 | 322924 | 6382 | 32184106 |
Hair colour changes | 15.39 | 11.26 | 44 | 322994 | 1633 | 32188855 |
Low density lipoprotein decreased | 15.37 | 11.26 | 33 | 323005 | 1020 | 32189468 |
Migraine | 15.35 | 11.26 | 79 | 322959 | 13906 | 32176582 |
White blood cell count decreased | 15.30 | 11.26 | 745 | 322293 | 90453 | 32100035 |
Intervertebral disc displacement | 15.29 | 11.26 | 13 | 323025 | 156 | 32190332 |
Tricuspid valve calcification | 15.21 | 11.26 | 5 | 323033 | 4 | 32190484 |
Atrioventricular block second degree | 15.20 | 11.26 | 71 | 322967 | 3359 | 32187129 |
Anxiety | 15.19 | 11.26 | 789 | 322249 | 95216 | 32095272 |
Bundle branch block | 15.17 | 11.26 | 31 | 323007 | 925 | 32189563 |
Arteriosclerosis | 15.10 | 11.26 | 172 | 322866 | 10862 | 32179626 |
Kidney small | 15.10 | 11.26 | 9 | 323029 | 58 | 32190430 |
Polypectomy | 15.08 | 11.26 | 23 | 323015 | 541 | 32189947 |
Therapy partial responder | 15.08 | 11.26 | 16 | 323022 | 4914 | 32185574 |
Crying | 15.04 | 11.26 | 22 | 323016 | 5874 | 32184614 |
Gastric cancer | 15.00 | 11.26 | 99 | 322939 | 5338 | 32185150 |
Thrombotic cerebral infarction | 14.95 | 11.26 | 18 | 323020 | 335 | 32190153 |
Band neutrophil percentage decreased | 14.94 | 11.26 | 6 | 323032 | 13 | 32190475 |
Ventricular tachycardia | 14.93 | 11.26 | 172 | 322866 | 25384 | 32165104 |
Nausea | 14.90 | 11.26 | 2886 | 320152 | 317963 | 31872525 |
Euphoric mood | 14.86 | 11.26 | 18 | 323020 | 5209 | 32185279 |
Pruritus | 14.84 | 11.26 | 1478 | 321560 | 127224 | 32063264 |
Diabetic neuropathy | 14.83 | 11.26 | 81 | 322957 | 4079 | 32186409 |
Prostatic specific antigen increased | 14.79 | 11.26 | 198 | 322840 | 12989 | 32177499 |
Musculoskeletal stiffness | 14.73 | 11.26 | 288 | 322750 | 38976 | 32151512 |
Coronary arterial stent insertion | 14.73 | 11.26 | 82 | 322956 | 4160 | 32186328 |
Device related infection | 14.65 | 11.26 | 111 | 322927 | 17822 | 32172666 |
Graft versus host disease in gastrointestinal tract | 14.57 | 11.26 | 8 | 323030 | 3433 | 32187055 |
High density lipoprotein decreased | 14.57 | 11.26 | 69 | 322969 | 3283 | 32187205 |
Psoriasis | 14.50 | 11.26 | 348 | 322690 | 45775 | 32144713 |
Generalised bullous fixed drug eruption | 14.49 | 11.26 | 4 | 323034 | 0 | 32190488 |
Non-compaction cardiomyopathy | 14.49 | 11.26 | 4 | 323034 | 0 | 32190488 |
Ventricular compliance decreased | 14.49 | 11.26 | 4 | 323034 | 0 | 32190488 |
Mucosal membrane hyperplasia | 14.49 | 11.26 | 4 | 323034 | 0 | 32190488 |
Blood aldosterone decreased | 14.49 | 11.26 | 4 | 323034 | 0 | 32190488 |
Vertebrobasilar stroke | 14.49 | 11.26 | 4 | 323034 | 0 | 32190488 |
Hypoinsulinaemia | 14.49 | 11.26 | 4 | 323034 | 0 | 32190488 |
Prostate cancer recurrent | 14.46 | 11.26 | 30 | 323008 | 905 | 32189583 |
Cutaneous lupus erythematosus | 14.42 | 11.26 | 26 | 323012 | 705 | 32189783 |
Delusion | 14.41 | 11.26 | 74 | 322964 | 13034 | 32177454 |
Hepatic enzyme increased | 14.40 | 11.26 | 270 | 322768 | 36767 | 32153721 |
Nasal crusting | 14.40 | 11.26 | 20 | 323018 | 431 | 32190057 |
Cataract | 14.37 | 11.26 | 328 | 322710 | 23855 | 32166633 |
Cystic fibrosis | 14.33 | 11.26 | 3 | 323035 | 2363 | 32188125 |
Hepatic function abnormal | 14.31 | 11.26 | 563 | 322475 | 44277 | 32146211 |
Freezing phenomenon | 14.31 | 11.26 | 3 | 323035 | 2360 | 32188128 |
Myopathy | 14.29 | 11.26 | 174 | 322864 | 11167 | 32179321 |
Enterococcal infection | 14.25 | 11.26 | 45 | 322993 | 9102 | 32181386 |
Hyperglycaemia | 14.18 | 11.26 | 490 | 322548 | 37901 | 32152587 |
Thirst | 14.16 | 11.26 | 123 | 322915 | 7227 | 32183261 |
Oxygen consumption decreased | 14.15 | 11.26 | 13 | 323025 | 174 | 32190314 |
Respiratory arrest | 14.13 | 11.26 | 202 | 322836 | 28706 | 32161782 |
Blood aldosterone increased | 14.09 | 11.26 | 6 | 323032 | 16 | 32190472 |
Viral infection | 14.04 | 11.26 | 99 | 322939 | 16151 | 32174337 |
Pollakiuria | 14.02 | 11.26 | 263 | 322775 | 18481 | 32172007 |
Coronary artery stenosis | 14.02 | 11.26 | 154 | 322884 | 9639 | 32180849 |
Cardiomegaly | 14.01 | 11.26 | 219 | 322819 | 14852 | 32175636 |
Bacteraemia | 14.01 | 11.26 | 110 | 322928 | 17523 | 32172965 |
Post-traumatic amnestic disorder | 13.88 | 11.26 | 8 | 323030 | 48 | 32190440 |
Respiratory failure | 13.87 | 11.26 | 898 | 322140 | 106284 | 32084204 |
Suspected suicide attempt | 13.85 | 11.26 | 11 | 323027 | 119 | 32190369 |
Drug screen positive | 13.85 | 11.26 | 13 | 323025 | 4228 | 32186260 |
Left atrial enlargement | 13.80 | 11.26 | 24 | 323014 | 632 | 32189856 |
Surfactant protein increased | 13.80 | 11.26 | 5 | 323033 | 7 | 32190481 |
Hypovolaemic shock | 13.76 | 11.26 | 116 | 322922 | 6756 | 32183732 |
Haemodynamic instability | 13.75 | 11.26 | 141 | 322897 | 8670 | 32181818 |
Pericardial disease | 13.69 | 11.26 | 17 | 323021 | 327 | 32190161 |
Clostridium difficile infection | 13.68 | 11.26 | 112 | 322926 | 17684 | 32172804 |
Peripheral artery occlusion | 13.59 | 11.26 | 41 | 322997 | 1569 | 32188919 |
Large intestine polyp | 13.57 | 11.26 | 120 | 322918 | 7086 | 32183402 |
Needle fatigue | 13.56 | 11.26 | 19 | 323019 | 413 | 32190075 |
Mycobacterium avium complex infection | 13.53 | 11.26 | 6 | 323032 | 2911 | 32187577 |
Blood cholinesterase decreased | 13.49 | 11.26 | 11 | 323027 | 124 | 32190364 |
Pelvic cyst | 13.48 | 11.26 | 7 | 323031 | 33 | 32190455 |
Sex hormone binding globulin increased | 13.41 | 11.26 | 5 | 323033 | 8 | 32190480 |
Crohn's disease | 13.41 | 11.26 | 14 | 323024 | 4331 | 32186157 |
Faeces discoloured | 13.38 | 11.26 | 215 | 322823 | 14662 | 32175826 |
Toxic nodular goitre | 13.36 | 11.26 | 6 | 323032 | 19 | 32190469 |
Unintentional medical device removal | 13.35 | 11.26 | 4 | 323034 | 2474 | 32188014 |
Cachexia | 13.30 | 11.26 | 32 | 323006 | 7077 | 32183411 |
Haemodialysis | 13.28 | 11.26 | 168 | 322870 | 10878 | 32179610 |
Sinus node dysfunction | 13.27 | 11.26 | 77 | 322961 | 3967 | 32186521 |
Body temperature increased | 13.26 | 11.26 | 97 | 322941 | 15694 | 32174794 |
Neonatal respiratory distress syndrome | 13.21 | 11.26 | 13 | 323025 | 4134 | 32186354 |
Nodal rhythm | 13.18 | 11.26 | 39 | 322999 | 1476 | 32189012 |
Seronegative arthritis | 13.15 | 11.26 | 30 | 323008 | 967 | 32189521 |
Device leakage | 13.14 | 11.26 | 16 | 323022 | 4620 | 32185868 |
Hepatitis B | 13.13 | 11.26 | 27 | 323011 | 6314 | 32184174 |
Wrong strength | 13.07 | 11.26 | 10 | 323028 | 102 | 32190386 |
Malaise | 13.06 | 11.26 | 1978 | 321060 | 175160 | 32015328 |
Bradykinesia | 13.01 | 11.26 | 14 | 323024 | 4272 | 32186216 |
Generalised oedema | 13.01 | 11.26 | 185 | 322853 | 12298 | 32178190 |
Bundle branch block left | 12.90 | 11.26 | 100 | 322938 | 5679 | 32184809 |
Tuberculosis | 12.87 | 11.26 | 44 | 322994 | 8685 | 32181803 |
Histology abnormal | 12.80 | 11.26 | 16 | 323022 | 310 | 32190178 |
Albumin urine present | 12.79 | 11.26 | 18 | 323020 | 393 | 32190095 |
Giant cell arteritis | 12.78 | 11.26 | 27 | 323011 | 825 | 32189663 |
Thromboangiitis obliterans | 12.71 | 11.26 | 6 | 323032 | 22 | 32190466 |
Low birth weight baby | 12.68 | 11.26 | 32 | 323006 | 6962 | 32183526 |
Fracture displacement | 12.67 | 11.26 | 8 | 323030 | 58 | 32190430 |
Product administered to patient of inappropriate age | 12.66 | 11.26 | 6 | 323032 | 2800 | 32187688 |
Antipsychotic drug level increased | 12.64 | 11.26 | 10 | 323028 | 3536 | 32186952 |
Acidosis | 12.64 | 11.26 | 164 | 322874 | 10682 | 32179806 |
Body temperature decreased | 12.61 | 11.26 | 166 | 322872 | 10848 | 32179640 |
Hypocalcaemia | 12.57 | 11.26 | 309 | 322729 | 22745 | 32167743 |
Dysmorphism | 12.56 | 11.26 | 6 | 323032 | 2787 | 32187701 |
Stomatitis | 12.51 | 11.26 | 304 | 322734 | 39925 | 32150563 |
Sinonasal obstruction | 12.51 | 11.26 | 6 | 323032 | 23 | 32190465 |
Hypertensive encephalopathy | 12.50 | 11.26 | 17 | 323021 | 359 | 32190129 |
Malabsorption | 12.45 | 11.26 | 49 | 322989 | 2148 | 32188340 |
Renal function test abnormal | 12.40 | 11.26 | 54 | 322984 | 2479 | 32188009 |
Neuralgia | 12.35 | 11.26 | 68 | 322970 | 11767 | 32178721 |
Drug abuser | 12.34 | 11.26 | 14 | 323024 | 4170 | 32186318 |
On and off phenomenon | 12.32 | 11.26 | 10 | 323028 | 3491 | 32186997 |
Kinematic imbalances due to suboccipital strain | 12.31 | 11.26 | 6 | 323032 | 24 | 32190464 |
Strongyloidiasis | 12.31 | 11.26 | 5 | 323033 | 2556 | 32187932 |
Macrophages increased | 12.24 | 11.26 | 12 | 323026 | 175 | 32190313 |
Haematochezia | 12.21 | 11.26 | 491 | 322547 | 38717 | 32151771 |
Multiple sclerosis relapse | 12.12 | 11.26 | 68 | 322970 | 11713 | 32178775 |
Dysphonia | 12.12 | 11.26 | 280 | 322758 | 20404 | 32170084 |
Atrial septal defect | 12.08 | 11.26 | 33 | 323005 | 6992 | 32183496 |
Urogenital haemorrhage | 12.07 | 11.26 | 20 | 323018 | 506 | 32189982 |
Lipoma | 12.05 | 11.26 | 38 | 323000 | 1490 | 32188998 |
Large intestinal polypectomy | 12.03 | 11.26 | 8 | 323030 | 64 | 32190424 |
Drug reaction with eosinophilia and systemic symptoms | 11.96 | 11.26 | 239 | 322799 | 32246 | 32158242 |
Gastrointestinal ischaemia | 11.93 | 11.26 | 13 | 323025 | 216 | 32190272 |
Tricuspid valve incompetence | 11.93 | 11.26 | 143 | 322895 | 9144 | 32181344 |
Dyspnoea | 11.91 | 11.26 | 3892 | 319146 | 358153 | 31832335 |
Incorrect route of product administration | 11.90 | 11.26 | 68 | 322970 | 11658 | 32178830 |
Yellow skin | 11.89 | 11.26 | 48 | 322990 | 2129 | 32188359 |
Dysgeusia | 11.85 | 11.26 | 335 | 322703 | 25196 | 32165292 |
Physical deconditioning | 11.83 | 11.26 | 26 | 323012 | 817 | 32189671 |
Serotonin syndrome | 11.83 | 11.26 | 127 | 322911 | 18990 | 32171498 |
Pneumocystis jirovecii pneumonia | 11.82 | 11.26 | 125 | 322913 | 18745 | 32171743 |
Hepatitis | 11.78 | 11.26 | 165 | 322873 | 23528 | 32166960 |
Platelet count decreased | 11.78 | 11.26 | 979 | 322059 | 113612 | 32076876 |
Lymphomatoid papulosis | 11.77 | 11.26 | 12 | 323026 | 184 | 32190304 |
Intestinal villi atrophy | 11.75 | 11.26 | 11 | 323027 | 151 | 32190337 |
Ventricular hypertrophy | 11.75 | 11.26 | 87 | 322951 | 4871 | 32185617 |
Muscle necrosis | 11.75 | 11.26 | 26 | 323012 | 821 | 32189667 |
Hepatotoxicity | 11.75 | 11.26 | 129 | 322909 | 19208 | 32171280 |
Epilepsy | 11.70 | 11.26 | 152 | 322886 | 21957 | 32168531 |
Hyperparathyroidism secondary | 11.65 | 11.26 | 32 | 323006 | 1160 | 32189328 |
Palatal oedema | 11.62 | 11.26 | 26 | 323012 | 827 | 32189661 |
Joint swelling | 11.62 | 11.26 | 627 | 322411 | 51108 | 32139380 |
Herpes zoster | 11.59 | 11.26 | 239 | 322799 | 32102 | 32158386 |
Portal hypertension | 11.55 | 11.26 | 14 | 323024 | 4050 | 32186438 |
Fulminant type 1 diabetes mellitus | 11.54 | 11.26 | 22 | 323016 | 623 | 32189865 |
Retinal vascular thrombosis | 11.54 | 11.26 | 8 | 323030 | 69 | 32190419 |
Blood potassium decreased | 11.53 | 11.26 | 239 | 322799 | 17099 | 32173389 |
Herbal interaction | 11.51 | 11.26 | 16 | 323022 | 345 | 32190143 |
Intraventricular haemorrhage | 11.49 | 11.26 | 62 | 322976 | 3108 | 32187380 |
Product solubility abnormal | 11.46 | 11.26 | 21 | 323017 | 577 | 32189911 |
Arterial stenosis | 11.43 | 11.26 | 33 | 323005 | 1232 | 32189256 |
Rhythm idioventricular | 11.41 | 11.26 | 15 | 323023 | 306 | 32190182 |
Cytomegalovirus colitis | 11.40 | 11.26 | 6 | 323032 | 2636 | 32187852 |
Acute biphenotypic leukaemia | 11.36 | 11.26 | 8 | 323030 | 71 | 32190417 |
Oedema | 11.33 | 11.26 | 553 | 322485 | 44594 | 32145894 |
Renal artery thrombosis | 11.27 | 11.26 | 15 | 323023 | 310 | 32190178 |
Phaeochromocytoma malignant | 11.27 | 11.26 | 8 | 323030 | 72 | 32190416 |
Source | Code | Description |
---|---|---|
ATC | C08CA01 | CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS Dihydropyridine derivatives |
ATC | C07FB07 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents and calcium channel blockers |
ATC | C07FB12 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents and calcium channel blockers |
ATC | C07FB13 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents and calcium channel blockers |
ATC | C08CA51 | CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS Dihydropyridine derivatives |
ATC | C08GA02 | CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS CALCIUM CHANNEL BLOCKERS AND DIURETICS Calcium channel blockers and diuretics |
ATC | C09BB03 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and calcium channel blockers |
ATC | C09BB04 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and calcium channel blockers |
ATC | C09BB07 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and calcium channel blockers |
ATC | C09BX01 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors, other combinations |
ATC | C09BX03 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors, other combinations |
ATC | C09BX04 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors, other combinations |
ATC | C09DB01 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DB02 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DB04 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DB05 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DB06 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DB07 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DB09 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers |
ATC | C09DX01 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
ATC | C09DX03 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
ATC | C09DX06 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
ATC | C09DX07 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations |
ATC | C09XA53 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM Renin-inhibitors |
ATC | C09XA54 | CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM Renin-inhibitors |
ATC | C10BX03 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX07 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX09 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX11 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX14 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
ATC | C10BX18 | CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs |
FDA CS | M0006414 | Dihydropyridines |
FDA MoA | N0000000069 | Calcium Channel Antagonists |
FDA EPC | N0000175421 | Dihydropyridine Calcium Channel Blocker |
CHEBI has role | CHEBI:35620 | vasodilator |
CHEBI has role | CHEBI:35674 | antihypertensive |
CHEBI has role | CHEBI:38215 | calcium channel blockers |
MeSH PA | D000959 | Antihypertensive Agents |
MeSH PA | D002121 | Calcium Channel Blockers |
MeSH PA | D000077264 | Calcium-Regulating Hormones and Agents |
MeSH PA | D002317 | Cardiovascular Agents |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D014665 | Vasodilator Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Hypertensive disorder | indication | 38341003 | DOID:10763 |
Prinzmetal angina | indication | 87343002 | |
Angina pectoris | indication | 194828000 | |
Cerebrovascular accident | indication | 230690007 | |
Primary Prevention of Coronary Heart Disease | indication | ||
Myocardial Infarction Prevention | indication | ||
Anuria | contraindication | 2472002 | DOID:2983 |
Alcoholism | contraindication | 7200002 | |
Hyperkalemia | contraindication | 14140009 | |
Jaundice | contraindication | 18165001 | |
Secondary angle-closure glaucoma | contraindication | 21571006 | |
Hypovolemia | contraindication | 28560003 | |
Obstruction of bile duct | contraindication | 30144000 | |
Dehydration | contraindication | 34095006 | |
Hyperuricemia | contraindication | 35885006 | DOID:1920 |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Angioedema | contraindication | 41291007 | DOID:1558 |
Hypokalemia | contraindication | 43339004 | |
Diabetes mellitus type 2 | contraindication | 44054006 | DOID:9352 |
Low blood pressure | contraindication | 45007003 | |
Systemic lupus erythematosus | contraindication | 55464009 | DOID:9074 |
Sympathectomy | contraindication | 57071006 | |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Hypochloremic alkalosis | contraindication | 70134007 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Chronic idiopathic constipation | contraindication | 82934008 | |
Hereditary angioneurotic edema | contraindication | 82966003 | DOID:14735 |
Hyponatremia | contraindication | 89627008 | |
Gout | contraindication | 90560007 | DOID:13189 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Disorder of connective tissue | contraindication | 105969002 | DOID:65 |
Disorder of muscle | contraindication | 129565002 | DOID:423 |
Liver function tests abnormal | contraindication | 166603001 | |
Hypomagnesemia | contraindication | 190855004 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Impaired renal function disorder | contraindication | 197663003 | |
Hemorrhagic cerebral infarction | contraindication | 230706003 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Rhabdomyolysis | contraindication | 240131006 | |
Neonatal hyperbilirubinemia | contraindication | 281610001 | |
Pregnancy, function | contraindication | 289908002 | |
Renal artery stenosis | contraindication | 302233006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Bone marrow depression | contraindication | 307762000 | |
Surgical procedure | contraindication | 387713003 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Traumatic injury | contraindication | 417746004 | |
Azotemia | contraindication | 445009001 | |
Head and Neck Angioedema | contraindication | ||
Hemodialysis with High-Flux Membrane | contraindication | ||
Severe Aortic Valve Stenosis | contraindication | ||
Intestinal Angioedema | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.0 | Basic |
pKa2 | 1.55 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
EQ 10MG BASE;14MG | PRESTALIA | ADHERA | N205003 | Jan. 21, 2015 | RX | TABLET | ORAL | 6696481 | April 15, 2023 | TREATMENT OF HYPERTENSION |
EQ 2.5MG BASE;3.5MG | PRESTALIA | ADHERA | N205003 | Jan. 21, 2015 | RX | TABLET | ORAL | 6696481 | April 15, 2023 | TREATMENT OF HYPERTENSION |
EQ 5MG BASE;7MG | PRESTALIA | ADHERA | N205003 | Jan. 21, 2015 | RX | TABLET | ORAL | 6696481 | April 15, 2023 | TREATMENT OF HYPERTENSION |
EQ 10MG BASE;200MG | CONSENSI | PURPLE BIOTECH | N210045 | May 31, 2018 | DISCN | TABLET | ORAL | 9662315 | May 22, 2029 | TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE |
EQ 2.5MG BASE;200MG | CONSENSI | PURPLE BIOTECH | N210045 | May 31, 2018 | DISCN | TABLET | ORAL | 9662315 | May 22, 2029 | TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE |
EQ 5MG BASE;200MG | CONSENSI | PURPLE BIOTECH | N210045 | May 31, 2018 | DISCN | TABLET | ORAL | 9662315 | May 22, 2029 | TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE |
EQ 10MG BASE;14MG | PRESTALIA | ADHERA | N205003 | Jan. 21, 2015 | RX | TABLET | ORAL | 7846961 | Oct. 5, 2029 | TREATMENT OF HYPERTENSION |
EQ 2.5MG BASE;3.5MG | PRESTALIA | ADHERA | N205003 | Jan. 21, 2015 | RX | TABLET | ORAL | 7846961 | Oct. 5, 2029 | TREATMENT OF HYPERTENSION |
EQ 5MG BASE;7MG | PRESTALIA | ADHERA | N205003 | Jan. 21, 2015 | RX | TABLET | ORAL | 7846961 | Oct. 5, 2029 | TREATMENT OF HYPERTENSION |
EQ 10MG BASE;200MG | CONSENSI | PURPLE BIOTECH | N210045 | May 31, 2018 | DISCN | TABLET | ORAL | 9408837 | Feb. 28, 2030 | TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE |
EQ 2.5MG BASE;200MG | CONSENSI | PURPLE BIOTECH | N210045 | May 31, 2018 | DISCN | TABLET | ORAL | 9408837 | Feb. 28, 2030 | TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE |
EQ 5MG BASE;200MG | CONSENSI | PURPLE BIOTECH | N210045 | May 31, 2018 | DISCN | TABLET | ORAL | 9408837 | Feb. 28, 2030 | TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE |
EQ 10MG BASE;200MG | CONSENSI | PURPLE BIOTECH | N210045 | May 31, 2018 | DISCN | TABLET | ORAL | 10925835 | June 14, 2038 | TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE |
EQ 2.5MG BASE;200MG | CONSENSI | PURPLE BIOTECH | N210045 | May 31, 2018 | DISCN | TABLET | ORAL | 10925835 | June 14, 2038 | TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE |
EQ 5MG BASE;200MG | CONSENSI | PURPLE BIOTECH | N210045 | May 31, 2018 | DISCN | TABLET | ORAL | 10925835 | June 14, 2038 | TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE |
EQ 1MG BASE/ML | NORLIQVA | CMP DEV LLC | N214439 | Feb. 24, 2022 | RX | SOLUTION | ORAL | 11253474 | Feb. 24, 2041 | NORLIQVA IS INDICATED FOR THE SYMPTOMATIC TREATMENT OF CHRONIC STABLE ANGINA |
EQ 1MG BASE/ML | NORLIQVA | CMP DEV LLC | N214439 | Feb. 24, 2022 | RX | SOLUTION | ORAL | 11253474 | Feb. 24, 2041 | NORLIQVA IS INDICATED FOR THE TREATMENT OF CONFIRMED OR SUSPECTED VASOSPASTIC ANGINA |
EQ 1MG BASE/ML | NORLIQVA | CMP DEV LLC | N214439 | Feb. 24, 2022 | RX | SOLUTION | ORAL | 11253474 | Feb. 24, 2041 | NORLIQVA IS INDICATED FOR THE TREATMENT OF HYPERTENSION, TO LOWER BLOOD PRESSURE IN ADULTS AND CHILDREN 6 YEARS OF AGE AND OLDER |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Voltage-dependent L-type calcium channel subunit alpha-1C | Ion channel | BLOCKER | WOMBAT-PK | CHEMBL | |||||
Voltage-dependent L-type calcium channel subunit alpha-1D | Ion channel | BLOCKER | Ki | 7 | WOMBAT-PK | CHEMBL | |||
Alpha-1A adrenergic receptor | GPCR | Ki | 5.63 | CHEMBL | |||||
Aldehyde oxidase | Enzyme | IC50 | 5.26 | WOMBAT-PK | |||||
Alpha-2C adrenergic receptor | GPCR | Ki | 6.58 | DRUG MATRIX | |||||
Sodium-dependent dopamine transporter | Transporter | Ki | 5.36 | DRUG MATRIX | |||||
Alpha-1D adrenergic receptor | GPCR | Ki | 5.27 | CHEMBL | |||||
Alpha-1B adrenergic receptor | GPCR | Ki | 5.10 | CHEMBL | |||||
Voltage-dependent calcium channel gamma-1 subunit | Ion channel | Ki | 7.20 | WOMBAT-PK | |||||
Carbonic anhydrase 1 | Enzyme | WOMBAT-PK | |||||||
Voltage-dependent calcium channel subunit alpha-2/delta-1 | Ion channel | Ki | 7.20 | WOMBAT-PK | |||||
Voltage-dependent T-type calcium channel subunit alpha-1H | Ion channel | Ki | 4.51 | WOMBAT-PK | |||||
Potassium channel subfamily K member 2 | Ion channel | IC50 | 6.40 | CHEMBL | |||||
Alpha-2A adrenergic receptor | GPCR | Ki | 6.65 | DRUG MATRIX | |||||
5-hydroxytryptamine receptor 6 | GPCR | Ki | 5.87 | DRUG MATRIX | |||||
Voltage-dependent L-type calcium channel subunit alpha-1C | Ion channel | Ki | 8.70 | CHEMBL | |||||
Potassium channel subfamily K member 2 | Ion channel | IC50 | 6.37 | CHEMBL |
ID | Source |
---|---|
4020813 | VUID |
N0000148333 | NUI |
D00615 | KEGG_DRUG |
111470-99-6 | SECONDARY_CAS_RN |
104416 | RXNORM |
C0051696 | UMLSCUI |
CHEBI:2669 | CHEBI |
6UB | PDB_CHEM_ID |
CHEMBL1491 | ChEMBL_ID |
CHEMBL1200402 | ChEMBL_ID |
CHEMBL1200984 | ChEMBL_ID |
D017311 | MESH_DESCRIPTOR_UI |
DB00381 | DRUGBANK_ID |
2162 | PUBCHEM_CID |
6981 | IUPHAR_LIGAND_ID |
5729 | INN_ID |
1J444QC288 | UNII |
108736 | MMSL |
173594 | MMSL |
23944 | MMSL |
27341 | MMSL |
4180 | MMSL |
d00689 | MMSL |
003672 | NDDF |
003673 | NDDF |
008599 | NDDF |
015579 | NDDF |
108537001 | SNOMEDCT_US |
384976003 | SNOMEDCT_US |
386864001 | SNOMEDCT_US |
421048000 | SNOMEDCT_US |
4020586 | VANDF |
4020813 | VANDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Norvasc | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-1520 | TABLET | 2.50 mg | ORAL | NDA | 26 sections |
Norvasc | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-1530 | TABLET | 5 mg | ORAL | NDA | 26 sections |
Norvasc | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-1540 | TABLET | 10 mg | ORAL | NDA | 26 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2150 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2160 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2170 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2180 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2190 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2250 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2260 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2270 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2960 | TABLET, FILM COATED | 2.50 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2970 | TABLET, FILM COATED | 2.50 mg | ORAL | NDA | 32 sections |
Caduet | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0069-2980 | TABLET, FILM COATED | 2.50 mg | ORAL | NDA | 32 sections |
Lotrel | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0364 | CAPSULE | 10 mg | ORAL | NDA | 31 sections |
Lotrel | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0379 | CAPSULE | 10 mg | ORAL | NDA | 31 sections |
Lotrel | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0405 | CAPSULE | 5 mg | ORAL | NDA | 31 sections |
Lotrel | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0406 | CAPSULE | 5 mg | ORAL | NDA | 31 sections |
Exforge | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0488 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 31 sections |
Exforge | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0489 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 31 sections |
Exforge | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0490 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 31 sections |
Exforge | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0078-0491 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 31 sections |
Exforge HCT | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0559 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 31 sections |
Exforge HCT | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0560 | TABLET, FILM COATED | 5 mg | ORAL | NDA | 31 sections |
Exforge HCT | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0561 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 31 sections |
Exforge HCT | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0562 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 31 sections |
Exforge HCT | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0078-0563 | TABLET, FILM COATED | 10 mg | ORAL | NDA | 31 sections |
Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0093-5002 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 26 sections |
Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0093-5003 | TABLET, FILM COATED | 10 mg | ORAL | ANDA | 26 sections |
Olmesartan Medoxomil, Amlodipine and Hydrochlorothiazide | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0093-5004 | TABLET, FILM COATED | 5 mg | ORAL | ANDA | 26 sections |