amlodipine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
calcium channel blockers, nifedipine derivatives	183	88150-42-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: amlodipine amlopres racemic amlodipine amlodipine besylate amlodipine besilate amlodipine maleate amlodipine mesylate amlodipine mesilate	A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION. Molecular weight: 408.88 Formula: C20H25ClN2O5 CLOGP: 3.43 LIPINSKI: 0 HAC: 7 HDO: 2 TPSA: 99.88 ALOGS: -4.74 ROTB: 10 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

amlodipine
amlopres
racemic amlodipine
amlodipine besylate
amlodipine besilate
amlodipine maleate
amlodipine mesylate
amlodipine mesilate

A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.

Molecular weight: 408.88
Formula: C20H25ClN2O5
CLOGP: 3.43
LIPINSKI: 0
HAC: 7
HDO: 2
TPSA: 99.88
ALOGS: -4.74
ROTB: 10

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
5	mg	O

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	10 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.35 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	74 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	17 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	7 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.01 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	34 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
July 31, 1992	FDA	PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	976.01	9.79	3129	383758	816204	49402033
Pemphigus	787.06	9.79	30	386857	120136	50098101
Maternal exposure during pregnancy	705.97	9.79	176	386711	159602	50058635
Systemic lupus erythematosus	667.39	9.79	132	386755	140490	50077747
Contraindicated product administered	652.44	9.79	167	386720	148791	50069446
Completed suicide	627.12	9.79	2324	384563	129565	50088672
Hand deformity	580.25	9.79	50	386837	100149	50118088
Glossodynia	577.50	9.79	95	386792	115474	50102763
Synovitis	559.69	9.79	130	386757	123735	50094502
Treatment failure	546.65	9.79	185	386702	137452	50080785
Hypotension	531.38	9.79	3346	383541	232123	49986114
Anti-cyclic citrullinated peptide antibody positive	521.45	9.79	3	386884	70584	50147653
Drug intolerance	498.74	9.79	564	386323	218540	49999697
Infusion related reaction	482.67	9.79	355	386532	169202	50049035
Pericarditis	479.08	9.79	31	386856	78658	50139579
Therapeutic product effect decreased	462.40	9.79	231	386656	135819	50082418
Arthropathy	445.04	9.79	334	386553	157572	50060665
Off label use	444.78	9.79	1992	384895	472434	49745803
Hyponatraemia	422.81	9.79	1653	385234	94486	50123751
Acute kidney injury	422.43	9.79	3087	383800	224971	49993266
Shock	413.97	9.79	640	386247	20010	50198227
Alopecia	408.89	9.79	783	386104	244264	49973973
Blood pressure inadequately controlled	391.37	9.79	300	386587	4080	50214157
Gingival hypertrophy	366.19	9.79	189	386698	1197	50217040
Wound	344.09	9.79	190	386697	105604	50112633
Oedema peripheral	336.32	9.79	2213	384674	155748	50062489
Rheumatoid arthritis	330.99	9.79	655	386232	201895	50016342
Non-cardiogenic pulmonary oedema	326.97	9.79	134	386753	447	50217790
Blood pressure increased	321.90	9.79	1927	384960	131205	50087032
Rheumatoid factor positive	308.40	9.79	18	386869	49841	50168396
Exposure during pregnancy	303.95	9.79	286	386601	120729	50097508
Hepatic enzyme increased	298.02	9.79	367	386520	137013	50081224
Fall	297.46	9.79	3885	383002	331047	49887190
Cerebrovascular accident	286.79	9.79	1457	385430	93223	50125014
Duodenal ulcer perforation	274.56	9.79	19	386868	45592	50172645
Hypersensitivity	272.83	9.79	795	386092	214366	50003871
Discomfort	271.16	9.79	257	386630	108123	50110114
Bradycardia	268.84	9.79	1090	385797	63336	50154901
Pain	268.27	9.79	2984	383903	575919	49642318
Orthostatic hypotension	263.01	9.79	649	386238	28832	50189405
Product use issue	254.88	9.79	471	386416	149004	50069233
Folliculitis	249.37	9.79	12	386875	39213	50179024
Helicobacter infection	230.76	9.79	49	386838	49653	50168584
Abdominal discomfort	225.80	9.79	957	385930	230684	49987553
Sleep disorder due to general medical condition, insomnia type	208.73	9.79	7	386880	31440	50186797
Swelling	205.67	9.79	814	386073	200058	50018179
Dizziness	200.88	9.79	3740	383147	342629	49875608
Renal impairment	200.85	9.79	1123	385764	74538	50143699
Vasoplegia syndrome	198.09	9.79	117	386770	997	50217240
Lactic acidosis	193.17	9.79	628	386259	32727	50185510
Hyperkalaemia	193	9.79	804	386083	47285	50170952
C-reactive protein abnormal	192.77	9.79	4	386883	27805	50190432
Angioedema	192.35	9.79	680	386207	36996	50181241
Muscle injury	188.67	9.79	29	386858	37082	50181155
Lower respiratory tract infection	182.53	9.79	278	386609	94923	50123314
Therapeutic product effect incomplete	177.62	9.79	265	386622	91250	50126987
Arthralgia	176.94	9.79	2329	384558	436373	49781864
Abortion spontaneous	174.89	9.79	51	386836	41721	50176516
Metabolic acidosis	165.20	9.79	661	386226	38164	50180073
Sinusitis	164.64	9.79	707	386180	169851	50048386
Infection	160.85	9.79	727	386160	172227	50046010
Joint swelling	160.68	9.79	1156	385731	244130	49974107
Impaired healing	157.03	9.79	181	386706	69605	50148632
Cardiac failure congestive	155.07	9.79	1141	385746	83241	50134996
Pregnancy	152.92	9.79	22	386865	29555	50188682
Toxicity to various agents	150.30	9.79	2370	384517	210129	50008108
Irritable bowel syndrome	149.73	9.79	105	386782	51336	50166901
Intentional overdose	149.13	9.79	902	385985	61602	50156635
Hypokalaemia	146.69	9.79	1163	385724	86829	50131408
Balance disorder	140.42	9.79	973	385914	69617	50148620
Condition aggravated	139.05	9.79	1526	385361	295532	49922705
Musculoskeletal stiffness	136.97	9.79	512	386375	127969	50090268
Device expulsion	136.72	9.79	27	386860	28795	50189442
Distributive shock	135.84	9.79	83	386804	757	50217480
Depressed level of consciousness	135.77	9.79	768	386119	51185	50167052
Creatinine renal clearance decreased	135.22	9.79	288	386599	11593	50206644
Drug abuse	132.72	9.79	157	386730	59689	50158548
Hypoglycaemia	129.58	9.79	776	386111	52805	50165432
Ill-defined disorder	129.29	9.79	136	386751	54518	50163719
Atrial fibrillation	128.31	9.79	1265	385622	100480	50117757
Injection site reaction	127.00	9.79	117	386770	49915	50168322
Blood creatinine increased	125.50	9.79	1004	385883	75156	50143081
Rash	123.52	9.79	2481	384406	434990	49783247
Myocardial infarction	118.21	9.79	1119	385768	87908	50130329
Sedation complication	115.77	9.79	226	386661	8540	50209697
Injection site erythema	114.90	9.79	251	386636	74685	50143552
Hypertensive crisis	113.53	9.79	286	386601	12868	50205369
Neurologic neglect syndrome	113.33	9.79	92	386795	1366	50216871
Decreased appetite	110.82	9.79	2154	384733	198769	50019468
Swollen tongue	103.59	9.79	464	386423	28166	50190071
Injection site pain	101.17	9.79	470	386417	110554	50107683
Renal failure	101.05	9.79	1253	385634	105380	50112857
Carotid artery thrombosis	100.82	9.79	87	386800	1412	50216825
Live birth	98.26	9.79	7	386880	16401	50201836
Cerebral infarction	95.26	9.79	372	386515	21232	50197005
Syncope	94.04	9.79	1202	385685	101800	50116437
Asthenia	92.62	9.79	3139	383748	315903	49902334
Rhabdomyolysis	91.67	9.79	561	386326	38466	50179771
Product use in unapproved indication	91.00	9.79	516	386371	115303	50102934
Anuria	89.35	9.79	237	386650	11007	50207230
Stomatitis	88.84	9.79	435	386452	100909	50117328
Intentional product use issue	87.61	9.79	298	386589	76620	50141617
Gastrointestinal disorder	86.56	9.79	399	386488	94057	50124180
Atrioventricular block complete	86.21	9.79	179	386708	7076	50211161
Pyrexia	84.99	9.79	2235	384652	377968	49840269
Sinus bradycardia	84.39	9.79	257	386630	12926	50205311
Blood pressure decreased	84.04	9.79	722	386165	55187	50163050
Drug interaction	82.04	9.79	2052	384835	197569	50020668
Hypertensive emergency	80.29	9.79	78	386809	1485	50216752
Dehydration	79.86	9.79	1622	385265	150827	50067410
Hemiplegia	79.51	9.79	175	386712	7206	50211031
Coronary artery disease	79.34	9.79	442	386445	29284	50188953
Blood calcium decreased	77.49	9.79	339	386548	20367	50197870
Hip arthroplasty	77.41	9.79	71	386816	30358	50187879
Adjustment disorder	75.45	9.79	85	386802	1934	50216303
Overdose	74.48	9.79	1123	385764	98604	50119633
Intentional self-injury	74.38	9.79	42	386845	23070	50195167
Blood urea increased	74.17	9.79	367	386520	23218	50195019
Hypertension	73.89	9.79	2126	384761	209077	50009160
Fibromyalgia	73.71	9.79	145	386742	44833	50173404
Sprue-like enteropathy	72.82	9.79	47	386840	476	50217761
Migraine	72.59	9.79	312	386575	74968	50143269
Subacute cutaneous lupus erythematosus	72.32	9.79	87	386800	2128	50216109
Circulatory collapse	72.24	9.79	324	386563	19676	50198561
Cognitive disorder	71.75	9.79	580	386307	43543	50174694
Chronic kidney disease	70.30	9.79	533	386354	39238	50178999
Foetal exposure during pregnancy	69.40	9.79	64	386823	27295	50190942
Cardiac failure	69.23	9.79	887	386000	75153	50143084
Atrioventricular block first degree	69.05	9.79	149	386738	6052	50212185
Angina pectoris	68.97	9.79	388	386499	25800	50192437
Acute myocardial infarction	68.87	9.79	421	386466	28852	50189385
Renin increased	67.40	9.79	30	386857	129	50218108
Injection site swelling	66.46	9.79	137	386750	41636	50176601
Febrile neutropenia	66.41	9.79	455	386432	97212	50121025
Pulmonary oedema	66.36	9.79	618	386269	48320	50169917
Palpitations	64.40	9.79	1048	385839	93458	50124779
Cardiogenic shock	64.28	9.79	263	386624	15336	50202901
Transient ischaemic attack	64.03	9.79	444	386443	31766	50186471
Drug level increased	62.87	9.79	303	386584	18965	50199272
Dyspnoea	61.65	9.79	4921	381966	542687	49675550
Product prescribing error	60.90	9.79	319	386568	20642	50197595
Loss of personal independence in daily activities	59.47	9.79	304	386583	69746	50148491
Psoriatic arthropathy	59.32	9.79	174	386713	46858	50171379
Injection site pruritus	57.38	9.79	141	386746	40270	50177967
Hyperglycaemia	57.28	9.79	475	386412	35930	50182307
Left ventricular hypertrophy	56.93	9.79	119	386768	4726	50213511
Linear IgA disease	55.99	9.79	58	386829	1196	50217041
Hypomagnesaemia	55.73	9.79	335	386552	22821	50195416
Personality disorder	55.31	9.79	110	386777	4214	50214023
Blister	54.63	9.79	405	386482	85013	50133224
Anaemia	53.78	9.79	2402	384485	250054	49968183
Proteinuria	53.43	9.79	260	386627	16337	50201900
Dysarthria	53.08	9.79	477	386410	36926	50181311
Blood pressure systolic increased	52.85	9.79	457	386430	34992	50183245
Rheumatoid nodule	52.48	9.79	16	386871	12719	50205518
Hepatic function abnormal	51.19	9.79	426	386461	32255	50185982
Neutropenia	51.14	9.79	809	386078	147156	50071081
Drug resistance	51.10	9.79	42	386845	18947	50199290
Knee arthroplasty	50.95	9.79	125	386762	35721	50182516
Inappropriate antidiuretic hormone secretion	50.57	9.79	217	386670	12926	50205311
Renal artery stenosis	50.27	9.79	63	386824	1609	50216628
Oliguria	49.65	9.79	157	386730	8059	50210178
Schizoaffective disorder	49.37	9.79	72	386815	2134	50216103
Melaena	49.16	9.79	363	386524	26501	50191736
Blood potassium decreased	48.32	9.79	463	386424	36482	50181755
Blood glucose increased	47.86	9.79	789	386098	70535	50147702
Carotid artery stenosis	46.32	9.79	108	386779	4623	50213614
Vasodilatation	46.17	9.79	71	386816	2208	50216029
Atrioventricular block	45.96	9.79	131	386756	6347	50211890
Tenosynovitis	45.90	9.79	12	386875	10553	50207684
Sedation	45.83	9.79	395	386492	30215	50188022
Infective pulmonary exacerbation of cystic fibrosis	45.61	9.79	4	386883	7905	50210332
Glomerular filtration rate decreased	45.31	9.79	193	386694	11459	50206778
Foot deformity	45.20	9.79	48	386839	19162	50199075
Pemphigoid	44.41	9.79	122	386765	5785	50212452
Haemorrhage subcutaneous	43.68	9.79	76	386811	2625	50215612
Injection site bruising	43.54	9.79	140	386747	36628	50181609
Renal disorder	43.33	9.79	359	386528	27146	50191091
Constipation	43.11	9.79	1783	385104	183925	50034312
Diabetes mellitus inadequate control	43.09	9.79	207	386680	12938	50205299
Weight increased	42.85	9.79	1195	385692	200696	50017541
Suspected suicide	42.65	9.79	113	386774	5244	50212993
Anti-neutrophil cytoplasmic antibody positive vasculitis	42.43	9.79	69	386818	2253	50215984
Malaise	42.09	9.79	3042	383845	332490	49885747
Injection site warmth	42.09	9.79	27	386860	13839	50204398
Nasopharyngitis	41.70	9.79	1139	385748	191788	50026449
Body temperature increased	41.70	9.79	113	386774	31228	50187009
Oedema	41.57	9.79	761	386126	69420	50148817
Fatigue	40.72	9.79	4764	382123	702837	49515400
Eating disorder	40.37	9.79	228	386659	15181	50203056
Loss of consciousness	39.68	9.79	1062	385825	103291	50114946
Premature labour	39.68	9.79	19	386868	11457	50206780
Drug dependence	39.50	9.79	56	386831	19703	50198534
Blood creatine phosphokinase increased	39.34	9.79	340	386547	26027	50192210
Urine output decreased	39.29	9.79	171	386716	10250	50207987
Caesarean section	39.17	9.79	37	386850	15602	50202635
Altered state of consciousness	38.92	9.79	294	386593	21616	50196621
Drug tolerance decreased	38.67	9.79	11	386876	9149	50209088
Wrong technique in product usage process	38.52	9.79	257	386630	55253	50162984
Chest pain	38.07	9.79	1685	385202	175197	50043040
Atrioventricular block second degree	38.04	9.79	85	386802	3536	50214701
Lip swelling	37.98	9.79	321	386566	24415	50193822
Urticaria	37.21	9.79	732	386155	128829	50089408
Glomerulonephritis rapidly progressive	36.78	9.79	38	386849	781	50217456
Multiple sclerosis relapse	36.72	9.79	186	386701	42778	50175459
Muscle spasms	35.97	9.79	1234	385653	124319	50093918
Haematochezia	35.76	9.79	464	386423	39418	50178819
Gingival swelling	35.38	9.79	85	386802	3710	50214527
Allergic reaction to excipient	35.38	9.79	24	386863	266	50217971
Hyperdynamic left ventricle	35.37	9.79	19	386868	132	50218105
Supraventricular extrasystoles	35.35	9.79	87	386800	3857	50214380
Gastrointestinal haemorrhage	34.74	9.79	769	386118	72552	50145685
Premature baby	34.68	9.79	54	386833	18283	50199954
Abortion induced	34.63	9.79	14	386873	9330	50208907
Nodal rhythm	34.37	9.79	51	386836	1536	50216701
Aphasia	34.30	9.79	351	386536	28143	50190094
Lacunar infarction	34.17	9.79	74	386813	3013	50215224
Hepatotoxicity	34.13	9.79	101	386786	27125	50191112
Aortic dissection	33.98	9.79	51	386836	1552	50216685
Ischaemic stroke	33.58	9.79	223	386664	15725	50202512
Red blood cell sedimentation rate increased	33.45	9.79	114	386773	29302	50188935
Device dislocation	33.15	9.79	72	386815	21474	50196763
Plasma cell myeloma	33.13	9.79	376	386511	30946	50187291
Drug withdrawal syndrome	32.94	9.79	91	386796	24990	50193247
Nephrosclerosis	32.87	9.79	38	386849	890	50217347
Hyperaldosteronism	32.19	9.79	21	386866	217	50218020
Therapeutic response decreased	32.11	9.79	220	386667	47011	50171226
Bladder irritation	32.05	9.79	20	386867	190	50218047
Bundle branch block right	32.05	9.79	93	386794	4552	50213685
Gingival bleeding	31.76	9.79	171	386716	11182	50207055
Injury	31.74	9.79	231	386656	48694	50169543
Swelling face	31.38	9.79	571	386316	52024	50166213
Metastases to bone	31.25	9.79	56	386831	17939	50200298
Ear pain	31.23	9.79	111	386776	28172	50190065
Motor dysfunction	31.21	9.79	133	386754	7898	50210339
Affect lability	31.18	9.79	144	386743	8854	50209383
Respiratory failure	31.04	9.79	915	385972	90266	50127971
Leukopenia	30.65	9.79	349	386538	67179	50151058
Pulmonary renal syndrome	30.59	9.79	25	386862	375	50217862
Fear of injection	30.49	9.79	5	386882	6098	50212139
Dyspnoea exertional	30.49	9.79	556	386331	50677	50167560
Intestinal malrotation	29.98	9.79	24	386863	349	50217888
Haematemesis	29.86	9.79	334	386553	27391	50190846
Septic shock	29.82	9.79	286	386601	56889	50161348
Enthesopathy	29.71	9.79	9	386878	7184	50211053
Blood potassium increased	29.67	9.79	221	386666	16177	50202060
Immunodeficiency	29.67	9.79	42	386845	14786	50203451
BRASH syndrome	29.31	9.79	19	386868	194	50218043
Suicide attempt	28.92	9.79	556	386331	51176	50167061
Hyperuricaemia	28.80	9.79	90	386797	4590	50213647
Ear infection	28.62	9.79	102	386785	25868	50192369
Angina unstable	28.37	9.79	114	386773	6592	50211645
Pollakiuria	28.32	9.79	293	386594	23558	50194679
Arrhythmia	28.26	9.79	382	386505	32750	50185487
Injection site urticaria	28.22	9.79	31	386856	12186	50206051
Lung diffusion test abnormal	28.10	9.79	17	386870	152	50218085
Product substitution issue	28.07	9.79	194	386693	13863	50204374
Myocardial ischaemia	27.94	9.79	168	386719	11445	50206792
Sinus arrest	27.75	9.79	48	386839	1650	50216587
Disorientation	27.41	9.79	402	386485	35082	50183155
Stillbirth	27.35	9.79	6	386881	5946	50212291
Unintended pregnancy	27.21	9.79	3	386884	4943	50213294
Product label on wrong product	27.17	9.79	7	386880	0	50218237
Product monitoring error	26.95	9.79	63	386824	2701	50215536
Premature delivery	26.71	9.79	92	386795	23571	50194666
Feeling abnormal	26.66	9.79	1194	385693	124298	50093939
Parkinsonism	26.64	9.79	136	386751	8711	50209526
Hypocalcaemia	26.62	9.79	318	386569	26498	50191739
Hemiparesis	26.58	9.79	252	386635	19796	50198441
Panniculitis	26.58	9.79	16	386871	8487	50209750
Uterine perforation	26.54	9.79	8	386879	6407	50211830
Hypervolaemia	26.48	9.79	305	386582	25194	50193043
Accidental exposure to product	26.46	9.79	89	386798	22968	50195269
Sensory loss	26.20	9.79	123	386764	7615	50210622
Myocardial depression	26.06	9.79	24	386863	426	50217811
Unintentional medical device removal	25.97	9.79	5	386882	5430	50212807
Haematotoxicity	25.90	9.79	14	386873	7881	50210356
Ischaemia	25.86	9.79	82	386805	4215	50214022
Nocturia	25.80	9.79	111	386776	6619	50211618
Ovarian cyst	25.73	9.79	42	386845	13954	50204283
Ageusia	25.63	9.79	164	386723	11419	50206818
Confusional state	25.59	9.79	1699	385188	184229	50034008
Bone erosion	25.54	9.79	31	386856	11656	50206581
Faeces discoloured	25.15	9.79	210	386677	15914	50202323
Myalgia	25.15	9.79	1177	385710	123142	50095095
Labile hypertension	25.13	9.79	24	386863	447	50217790
Gangrene	25.07	9.79	86	386801	4606	50213631
Listless	24.99	9.79	56	386831	2334	50215903
Arteriosclerosis	24.91	9.79	136	386751	8941	50209296
Generalised oedema	24.81	9.79	185	386702	13546	50204691
Hyperlipidaemia	24.78	9.79	223	386664	17267	50200970
Gastric ulcer haemorrhage	24.68	9.79	83	386804	4401	50213836
Glycosylated haemoglobin increased	24.61	9.79	152	386735	10454	50207783
Type 2 diabetes mellitus	24.43	9.79	158	386729	34217	50184020
Aortic aneurysm	24.38	9.79	67	386820	3178	50215059
Scleral discolouration	24.33	9.79	21	386866	341	50217896
Loose tooth	24.31	9.79	67	386820	3183	50215054
Pathogen resistance	23.71	9.79	7	386880	5682	50212555
Mental status changes	23.50	9.79	399	386488	35873	50182364
Dysphagia	23.49	9.79	767	386120	76751	50141486
Fibromuscular dysplasia	23.24	9.79	16	386871	182	50218055
Blood pressure abnormal	23.18	9.79	172	386715	12575	50205662
Heavy menstrual bleeding	23.02	9.79	53	386834	15484	50202753
C-reactive protein increased	22.76	9.79	364	386523	66110	50152127
Pleural effusion	22.67	9.79	798	386089	80656	50137581
Tubulointerstitial nephritis	22.62	9.79	196	386691	15015	50203222
Neovascularisation	22.58	9.79	33	386854	980	50217257
Hypoglycaemic coma	22.56	9.79	53	386834	2280	50215957
Conjoined twins	22.47	9.79	18	386869	262	50217975
Hepatocellular carcinoma	22.22	9.79	48	386839	1951	50216286
Joint effusion	22.18	9.79	41	386846	12980	50205257
Acute coronary syndrome	22.16	9.79	135	386752	9239	50208998
Foetal death	22.12	9.79	18	386869	8162	50210075
Subdural haematoma	22.03	9.79	172	386715	12775	50205462
Acute motor-sensory axonal neuropathy	22.02	9.79	18	386869	270	50217967
Tongue oedema	21.96	9.79	72	386815	3767	50214470
Psychotic disorder	21.88	9.79	89	386798	21723	50196514
Lymphocyte stimulation test positive	21.87	9.79	23	386864	483	50217754
Device difficult to use	21.84	9.79	26	386861	9860	50208377
Cholecystitis chronic	21.82	9.79	25	386862	9644	50208593
Injection site rash	21.76	9.79	58	386829	16119	50202118
Harlequin syndrome	21.53	9.79	9	386878	32	50218205
Haemoglobin decreased	21.53	9.79	1184	385703	126032	50092205
Prescription drug used without a prescription	21.45	9.79	43	386844	1657	50216580
Haemodialysis	21.43	9.79	123	386764	8239	50209998
Inflammation	21.41	9.79	306	386581	56606	50161631
Lichen nitidus	21.40	9.79	11	386876	69	50218168
Atrioventricular dissociation	21.34	9.79	16	386871	210	50218027
Nephrogenic systemic fibrosis	21.19	9.79	77	386810	4245	50213992
Therapy partial responder	21.17	9.79	12	386875	6579	50211658
Disability	21.08	9.79	41	386846	12734	50205503
Hypoperfusion	20.96	9.79	37	386850	1293	50216944
Tendonitis	20.91	9.79	62	386825	16643	50201594
Diabetic nephropathy	20.78	9.79	37	386850	1302	50216935
Blood aldosterone increased	20.65	9.79	14	386873	155	50218082
Dysgeusia	20.65	9.79	415	386472	38501	50179736
Chronic pigmented purpura	20.65	9.79	11	386876	75	50218162
Diarrhoea	20.63	9.79	4934	381953	583542	49634695
Medication error	20.50	9.79	389	386498	35715	50182522
Hyperkaliuria	20.37	9.79	10	386877	56	50218181
Blood glucose decreased	20.35	9.79	221	386666	17990	50200247
Hypernatraemia	20.33	9.79	99	386788	6222	50212015
Hypertensive heart disease	20.26	9.79	50	386837	2220	50216017
Autoimmune enteropathy	20.25	9.79	6	386881	4	50218233
Electrocardiogram abnormal	20.23	9.79	113	386774	7492	50210745
Anaphylactic reaction	20.21	9.79	291	386596	53764	50164473
Venoocclusive liver disease	20.19	9.79	4	386883	4257	50213980
Dementia	20.19	9.79	199	386688	15798	50202439
Gingival atrophy	20.14	9.79	8	386879	24	50218213
Retinal ischaemia	20.13	9.79	18	386869	307	50217930
Grip strength decreased	19.92	9.79	39	386848	12082	50206155
Gingivitis	19.89	9.79	109	386778	7175	50211062
Device adhesion issue	19.83	9.79	3	386884	3882	50214355
Irritability	19.52	9.79	132	386755	28294	50189943
Gestational diabetes	19.49	9.79	17	386870	7448	50210789
Lymphocele	19.42	9.79	27	386860	765	50217472
Urine albumin/creatinine ratio increased	19.38	9.79	15	386872	207	50218030
Hypoglossal nerve paralysis	19.27	9.79	7	386880	15	50218222
Skin tightness	19.27	9.79	68	386819	3695	50214542
Mucosal inflammation	19.19	9.79	205	386682	39937	50178300
Hypertensive encephalopathy	19.17	9.79	23	386864	561	50217676
Bone marrow failure	19.11	9.79	128	386759	27496	50190741
Ankylosing spondylitis	19.09	9.79	16	386871	7149	50211088
Sinus rhythm	19.06	9.79	24	386863	616	50217621
Acute hepatic failure	19.04	9.79	59	386828	15618	50202619
Hypothermia	19.01	9.79	157	386730	11859	50206378
Upper respiratory tract infection	19.00	9.79	372	386515	65526	50152711
Pseudolymphoma	18.98	9.79	23	386864	567	50217670
Heart rate decreased	18.97	9.79	388	386499	36109	50182128
Periodontitis	18.87	9.79	59	386828	3010	50215227
Gallbladder adenocarcinoma	18.79	9.79	11	386876	92	50218145
Purpura	18.75	9.79	135	386752	9776	50208461
Oral discharge	18.73	9.79	13	386874	150	50218087
Haemodynamic instability	18.62	9.79	115	386772	7909	50210328
Upper gastrointestinal haemorrhage	18.57	9.79	196	386691	15839	50202398
Reduced facial expression	18.55	9.79	39	386848	1555	50216682
Blood uric acid increased	18.54	9.79	68	386819	3766	50214471
Mydriasis	18.52	9.79	33	386854	10594	50207643
Skin candida	18.51	9.79	35	386852	1291	50216946
Device issue	18.50	9.79	84	386803	19888	50198349
Blood lactic acid increased	18.34	9.79	88	386799	5497	50212740
Staphylococcal infection	18.22	9.79	179	386708	35437	50182800
Febrile bone marrow aplasia	18.20	9.79	13	386874	6298	50211939
Sickle cell anaemia with crisis	18.20	9.79	6	386881	4537	50213700
Acute myeloid leukaemia	18.12	9.79	57	386830	15017	50203220
Seizure	18.07	9.79	727	386160	117147	50101090
Rectourethral fistula	18.05	9.79	8	386879	34	50218203
Colitis ulcerative	18.04	9.79	67	386820	16787	50201450
Mood swings	18.02	9.79	62	386825	15892	50202345
Blood cholesterol increased	18.02	9.79	305	386582	54910	50163327
Head discomfort	17.99	9.79	145	386742	10874	50207363
Drug hypersensitivity	17.98	9.79	1663	385224	249347	49968890
Vision blurred	17.97	9.79	754	386133	77893	50140344
Cardiac disorder	17.96	9.79	443	386444	42536	50175701
Rectal ulcer haemorrhage	17.90	9.79	13	386874	162	50218075
Pericardial effusion	17.87	9.79	285	386602	25304	50192933
Blood loss anaemia	17.86	9.79	115	386772	8024	50210213
Protein urine present	17.86	9.79	85	386802	5292	50212945
Adenoma benign	17.64	9.79	26	386861	778	50217459
Blood parathyroid hormone decreased	17.62	9.79	17	386870	7097	50211140
Abnormal loss of weight	17.51	9.79	81	386806	4983	50213254
Restlessness	17.45	9.79	280	386607	24893	50193344
Congenital bladder anomaly	17.32	9.79	13	386874	171	50218066
Body tinea	17.26	9.79	34	386853	1293	50216944
Presyncope	17.09	9.79	270	386617	23928	50194309
Product storage error	17.08	9.79	43	386844	12181	50206056
Cardiac failure chronic	17.06	9.79	63	386824	3500	50214737
Fryns syndrome	17.06	9.79	9	386878	60	50218177
Vitello-intestinal duct remnant	17.02	9.79	8	386879	40	50218197
Putamen haemorrhage	17.01	9.79	13	386874	176	50218061
Urachal abnormality	16.82	9.79	13	386874	179	50218058
Anorexia nervosa	16.82	9.79	13	386874	179	50218058
Lethargy	16.80	9.79	496	386391	48936	50169301
Nephrogenic anaemia	16.78	9.79	39	386848	1666	50216571
Adverse drug reaction	16.76	9.79	309	386578	54913	50163324
Granuloma skin	16.76	9.79	12	386875	5806	50212431
Premature rupture of membranes	16.75	9.79	7	386880	4573	50213664
Lymphocyte count decreased	16.68	9.79	125	386762	26182	50192055
Nodule	16.67	9.79	70	386817	16933	50201304
Bursitis	16.63	9.79	100	386787	22035	50196202
Status epilepticus	16.61	9.79	50	386837	13356	50204881
Gravitational oedema	16.57	9.79	31	386856	1134	50217103
Urinary retention	16.57	9.79	287	386600	25903	50192334
Transcription medication error	16.53	9.79	13	386874	184	50218053
Benign neoplasm of adrenal gland	16.51	9.79	7	386880	26	50218211
Peripheral arterial occlusive disease	16.49	9.79	62	386825	3475	50214762
Gingival pain	16.49	9.79	90	386797	5916	50212321
Albuminuria	16.41	9.79	13	386874	186	50218051
Ventricular failure	16.39	9.79	17	386870	351	50217886
Cytomegalovirus infection	16.37	9.79	76	386811	17886	50200351
Myelosuppression	16.33	9.79	51	386836	13466	50204771
Coordination abnormal	16.31	9.79	147	386740	11387	50206850
Skin discolouration	16.29	9.79	346	386541	32411	50185826
Cardiac arrest	16.28	9.79	789	386098	82862	50135375
Injection site haemorrhage	16.26	9.79	96	386791	21250	50196987
Cerebral haemorrhage	16.24	9.79	294	386593	26758	50191479
Cardiomegaly	16.23	9.79	190	386697	15755	50202482
Organ failure	16.19	9.79	47	386840	2301	50215936
Neurotoxicity	16.17	9.79	58	386829	14682	50203555
Insulin-like growth factor decreased	16.16	9.79	17	386870	357	50217880
Skin induration	16.12	9.79	54	386833	2857	50215380
Osteopenia	16.11	9.79	71	386816	16947	50201290
Blood sodium decreased	16.10	9.79	239	386648	20908	50197329
Skin weeping	16.10	9.79	18	386869	406	50217831
Persistent cloaca	16.07	9.79	13	386874	192	50218045
Suspected product quality issue	16.07	9.79	13	386874	192	50218045
Vertigo	15.99	9.79	514	386373	51318	50166919
Mitral valve incompetence	15.97	9.79	204	386683	17267	50200970
Hypergastrinaemia	15.94	9.79	10	386877	96	50218141
Saliva discolouration	15.93	9.79	7	386880	29	50218208
Cerebral ischaemia	15.86	9.79	88	386799	5820	50212417
Cough	15.86	9.79	2091	384796	239173	49979064
Dialysis	15.85	9.79	125	386762	9313	50208924
Pulse abnormal	15.80	9.79	40	386847	1805	50216432
Gastrointestinal toxicity	15.78	9.79	8	386879	4669	50213568
Generalised tonic-clonic seizure	15.75	9.79	127	386760	26183	50192054
Humerus fracture	15.72	9.79	106	386781	7512	50210725
Congenital acrochordon	15.72	9.79	8	386879	49	50218188
Renal cell carcinoma	15.68	9.79	56	386831	3061	50215176
Haemorrhage intracranial	15.65	9.79	154	386733	12220	50206017
Fluid intake reduced	15.63	9.79	56	386831	3066	50215171
Osteoporosis	15.61	9.79	245	386642	44634	50173603
Substance abuse	15.58	9.79	6	386881	4118	50214119
CD30 expression	15.57	9.79	7	386880	31	50218206
Adverse event	15.53	9.79	238	386649	43525	50174712
Peritoneal effluent leukocyte count increased	15.53	9.79	4	386883	0	50218237
Complication of device insertion	15.48	9.79	14	386873	6027	50212210
Metabolic alkalosis	15.43	9.79	51	386836	2680	50215557
Tachypnoea	15.42	9.79	175	386712	14402	50203835
Blood cholinesterase decreased	15.35	9.79	10	386877	103	50218134
Carotid arteriosclerosis	15.29	9.79	27	386860	944	50217293
Full blood count decreased	15.28	9.79	248	386639	22098	50196139
Maternal drugs affecting foetus	15.25	9.79	10	386877	5067	50213170
Device deployment issue	15.13	9.79	4	386883	3492	50214745
Coeliac disease	15.11	9.79	27	386860	8658	50209579
Infected dermal cyst	15.10	9.79	18	386869	436	50217801
Jaundice	15.09	9.79	285	386602	26144	50192093
Ventricular septal defect	15.06	9.79	6	386881	4035	50214202
Zinc deficiency	15.06	9.79	7	386880	34	50218203
Taste disorder	14.95	9.79	112	386775	8212	50210025
Dermatitis bullous	14.92	9.79	100	386787	7073	50211164
Neurosensory hypoacusis	14.91	9.79	13	386874	214	50218023
Dysphoria	14.90	9.79	9	386878	4765	50213472
Hypertensive angiopathy	14.83	9.79	9	386878	81	50218156
Hyperplastic cholecystopathy	14.83	9.79	9	386878	81	50218156
Joint stiffness	14.80	9.79	154	386733	30154	50188083
Oropharyngeal swelling	14.79	9.79	24	386863	782	50217455
Finger deformity	14.76	9.79	13	386874	5669	50212568
Schizophrenia	14.75	9.79	21	386866	7376	50210861
Apical granuloma	14.74	9.79	7	386880	36	50218201
Inhibitory drug interaction	14.73	9.79	44	386843	2189	50216048
Exercise tolerance decreased	14.73	9.79	75	386812	4799	50213438
Kidney transplant rejection	14.71	9.79	65	386822	3922	50214315
Acute respiratory failure	14.63	9.79	305	386582	28477	50189760
Temperature regulation disorder	14.61	9.79	7	386880	4220	50214017
Forced vital capacity decreased	14.60	9.79	26	386861	915	50217322
Product solubility abnormal	14.59	9.79	23	386864	731	50217506
Sleep disorder	14.57	9.79	330	386557	56953	50161284
Electrocardiogram U wave present	14.56	9.79	9	386878	84	50218153
Joint injury	14.56	9.79	102	386785	21687	50196550
Arterial occlusive disease	14.54	9.79	74	386813	4734	50213503
Soft tissue disorder	14.53	9.79	7	386880	4207	50214030
Post transplant lymphoproliferative disorder	14.47	9.79	7	386880	4197	50214040
Renal transplant	14.39	9.79	30	386857	1189	50217048
Vasculitis	14.37	9.79	167	386720	13824	50204413
Ventricular extrasystoles	14.35	9.79	133	386754	10383	50207854
Oxalosis	14.29	9.79	7	386880	39	50218198
Hyperprolactinaemia	14.28	9.79	4	386883	3361	50214876
Norepinephrine increased	14.28	9.79	8	386879	61	50218176
Chondroma	14.21	9.79	6	386881	22	50218215
Pancreatic toxicity	14.21	9.79	6	386881	22	50218215
Amenorrhoea	14.20	9.79	27	386860	8457	50209780
Kidney fibrosis	14.19	9.79	35	386852	1554	50216683
Thirst	14.18	9.79	134	386753	10516	50207721
Crush syndrome	14.15	9.79	10	386877	119	50218118
Gout	14.14	9.79	142	386745	11328	50206909
Renal tubular necrosis	14.08	9.79	129	386758	10039	50208198
Labelled drug-drug interaction medication error	14.04	9.79	132	386755	10345	50207892
Cytokine release syndrome	14.00	9.79	28	386859	8606	50209631
Congenital nail disorder	13.96	9.79	9	386878	91	50218146
Multiple-drug resistance	13.95	9.79	4	386883	3310	50214927
Intestinal ischaemia	13.93	9.79	94	386793	6663	50211574
Hallucination, gustatory	13.86	9.79	8	386879	65	50218172
Skin necrosis	13.85	9.79	40	386847	10827	50207410
Dermatosis	13.84	9.79	13	386874	237	50218000
Dyslalia	13.78	9.79	17	386870	427	50217810
Genital haemorrhage	13.78	9.79	18	386869	6556	50211681
Prescribed overdose	13.77	9.79	61	386826	14539	50203698
Microalbuminuria	13.71	9.79	15	386872	330	50217907
Dystonia	13.71	9.79	46	386841	11880	50206357
Burn oesophageal	13.68	9.79	11	386876	161	50218076
Platelet aggregation decreased	13.63	9.79	6	386881	25	50218212
Rib deformity	13.62	9.79	11	386876	162	50218075
Cerebrovascular disorder	13.56	9.79	47	386840	2531	50215706
Deformity	13.53	9.79	25	386862	7915	50210322
Electrolyte imbalance	13.45	9.79	195	386692	16974	50201263
Hyperparathyroidism secondary	13.42	9.79	31	386856	1319	50216918
Dermatitis exfoliative	13.41	9.79	76	386811	5066	50213171
Diverticulum intestinal haemorrhagic	13.39	9.79	29	386858	1181	50217056
Hypomania	13.36	9.79	9	386878	4496	50213741
Intestinal villi atrophy	13.30	9.79	11	386876	168	50218069
Suicidal ideation	13.27	9.79	322	386565	55063	50163174
Bradyarrhythmia	13.19	9.79	38	386849	1852	50216385
Device malfunction	13.18	9.79	65	386822	15056	50203181
Essential hypertension	13.16	9.79	68	386819	4376	50213861
Sinus arrhythmia	13.13	9.79	31	386856	1338	50216899
Stomatitis haemorrhagic	13.09	9.79	6	386881	28	50218209
Lichen planus	13.06	9.79	39	386848	1940	50216297
Macular degeneration	13.04	9.79	61	386826	14327	50203910
Capillary disorder	13.00	9.79	8	386879	74	50218163
Skin haemorrhage	12.95	9.79	94	386793	6824	50211413
Cystic fibrosis	12.93	9.79	3	386884	2861	50215376
Ischaemic cardiomyopathy	12.90	9.79	43	386844	2269	50215968
Toxic epidermal necrolysis	12.90	9.79	229	386658	20763	50197474
Retroperitoneal haematoma	12.88	9.79	47	386840	2596	50215641
Interstitial lung disease	12.88	9.79	513	386374	52663	50165574
Cell marker increased	12.87	9.79	13	386874	260	50217977
Pigmentation disorder	12.87	9.79	60	386827	3704	50214533
Atrial pressure increased	12.84	9.79	5	386882	14	50218223
No adverse event	12.82	9.79	180	386707	33398	50184839
Blood sodium increased	12.81	9.79	44	386843	2358	50215879
Diabetes mellitus	12.81	9.79	477	386410	48556	50169681
Venous aneurysm	12.78	9.79	4	386883	4	50218233
Jaundice hepatocellular	12.77	9.79	6	386881	30	50218207
Sinus node dysfunction	12.76	9.79	62	386825	3893	50214344
Heat illness	12.74	9.79	10	386877	141	50218096
Metastatic renal cell carcinoma	12.68	9.79	22	386865	758	50217479
Cerebral atrophy	12.67	9.79	69	386818	4532	50213705
Pulmonary hypertension	12.66	9.79	340	386547	33077	50185160
Bowel movement irregularity	12.66	9.79	62	386825	3906	50214331
Diffuse large B-cell lymphoma refractory	12.65	9.79	26	386861	1020	50217217
Duodenal ulcer	12.65	9.79	92	386795	6683	50211554
Multiple drug therapy	12.62	9.79	38	386849	1899	50216338
Nephropathy	12.61	9.79	76	386811	5182	50213055
Renal aneurysm	12.59	9.79	5	386882	15	50218222
Psychogenic visual disorder	12.59	9.79	5	386882	15	50218222
Hepatorenal failure	12.52	9.79	19	386868	584	50217653
Maternal exposure timing unspecified	12.50	9.79	6	386881	3614	50214623
Dislocation of vertebra	12.50	9.79	4	386883	3083	50215154
Femoral neck fracture	12.47	9.79	99	386788	7391	50210846
Eye oedema	12.43	9.79	30	386857	1313	50216924
Duodenal ulcer repair	12.43	9.79	7	386880	54	50218183
Small cell carcinoma	12.40	9.79	10	386877	147	50218090
Gingival disorder	12.39	9.79	53	386834	3152	50215085
Normal newborn	12.37	9.79	20	386867	6671	50211566
Blood cholinesterase increased	12.35	9.79	5	386882	16	50218221
Thalamus haemorrhage	12.35	9.79	19	386868	591	50217646
Ocular icterus	12.33	9.79	56	386831	3419	50214818
Hospice care	12.33	9.79	81	386806	5691	50212546
Bromhidrosis	12.32	9.79	4	386883	5	50218232
Lymphadenopathy	12.29	9.79	181	386706	33318	50184919
Gastrointestinal stromal tumour	12.29	9.79	24	386863	907	50217330
Concomitant disease progression	12.28	9.79	39	386848	2006	50216231
Hypoacusis	12.26	9.79	224	386663	20423	50197814
Retinopathy hypertensive	12.24	9.79	12	386875	231	50218006
Biopsy kidney	12.20	9.79	9	386878	115	50218122
Sensorimotor disorder	12.20	9.79	16	386871	428	50217809
Sudden hearing loss	12.16	9.79	26	386861	1049	50217188
Injection site induration	12.15	9.79	29	386858	8368	50209869
Enterochromaffin cell hyperplasia	12.11	9.79	7	386880	57	50218180
Acute pulmonary oedema	12.07	9.79	96	386791	7171	50211066
Rales	12.05	9.79	123	386764	9855	50208382
Ventricular internal diameter abnormal	12.03	9.79	6	386881	35	50218202
Anti-erythropoietin antibody positive	12.00	9.79	15	386872	382	50217855
Hand dermatitis	12.00	9.79	8	386879	86	50218151
Bladder sphincter atony	11.97	9.79	10	386877	155	50218082
Muscular weakness	11.96	9.79	862	386025	94151	50124086
Hypophagia	11.94	9.79	287	386600	27441	50190796
Faeces hard	11.93	9.79	33	386854	1571	50216666
Hypoxia	11.87	9.79	491	386396	50632	50167605
Breast cancer stage III	11.87	9.79	5	386882	3251	50214986
Bifascicular block	11.82	9.79	9	386878	121	50218116
Blood phosphorus increased	11.82	9.79	45	386842	2537	50215700
Agitation	11.81	9.79	314	386573	53070	50165167
Dry skin	11.73	9.79	422	386465	42769	50175468
Renal function test abnormal	11.71	9.79	48	386839	2801	50215436
Cytotoxic oedema	11.70	9.79	9	386878	123	50218114
Gamma-glutamyltransferase increased	11.69	9.79	303	386584	29320	50188917
Immune reconstitution inflammatory syndrome	11.67	9.79	15	386872	5501	50212736
Glucose tolerance impaired	11.65	9.79	73	386814	5045	50213192
Tongue abscess	11.64	9.79	3	386884	0	50218237
Peripheral nerve paresis	11.64	9.79	3	386884	0	50218237
Adrenal gland cancer metastatic	11.64	9.79	3	386884	0	50218237
Carbohydrate metabolism disorder	11.64	9.79	3	386884	0	50218237
Cardiac index increased	11.64	9.79	3	386884	0	50218237
Mixed dementia	11.64	9.79	3	386884	0	50218237
Blood pressure difference of extremities	11.64	9.79	3	386884	0	50218237
Typical aura without headache	11.64	9.79	3	386884	0	50218237
Azotaemia	11.64	9.79	61	386826	3947	50214290
Skin exfoliation	11.62	9.79	338	386549	33274	50184963
Congenital diaphragmatic hernia	11.60	9.79	11	386876	203	50218034
Urinary incontinence	11.56	9.79	290	386597	27918	50190319
Yellow skin	11.56	9.79	38	386849	1991	50216246
Retroperitoneal oedema	11.51	9.79	5	386882	20	50218217
Leukaemic infiltration renal	11.51	9.79	5	386882	20	50218217
Pernicious anaemia	11.50	9.79	19	386868	629	50217608
Vaginal haemorrhage	11.49	9.79	126	386761	24425	50193812
Head banging	11.48	9.79	15	386872	400	50217837
Device use error	11.47	9.79	14	386873	5252	50212985
Cerebellar haemorrhage	11.47	9.79	28	386859	1235	50217002
Brain stem infarction	11.46	9.79	21	386866	756	50217481
Tonsillar inflammation	11.41	9.79	8	386879	94	50218143
Blood lactic acid	11.34	9.79	8	386879	95	50218142
Internal haemorrhage	11.34	9.79	65	386822	4352	50213885
Liver injury	11.33	9.79	128	386759	24678	50193559
Congenital syphilitic osteochondritis	11.32	9.79	5	386882	21	50218216
Hallucination, visual	11.32	9.79	184	386703	16398	50201839
Cardiac hypertrophy	11.28	9.79	24	386863	965	50217272
Aggression	11.28	9.79	105	386782	21011	50197226
Hypereosinophilic syndrome	11.22	9.79	12	386875	257	50217980
Pulmonary arterial hypertension	11.22	9.79	218	386669	20101	50198136
Synovial cyst	11.20	9.79	29	386858	8137	50210100
Rheumatoid factor negative	11.20	9.79	18	386869	582	50217655
Hypertonic bladder	11.13	9.79	49	386838	2951	50215286
Oesophageal food impaction	11.11	9.79	10	386877	172	50218065
Drug tolerance	11.09	9.79	13	386874	4963	50213274
Malignant hypertension	11.05	9.79	25	386862	1049	50217188
Dilatation ventricular	11.04	9.79	41	386846	2284	50215953
Myoglobin blood increased	11.04	9.79	28	386859	1265	50216972
Colitis ischaemic	11.02	9.79	116	386771	9367	50208870
Gastric pH increased	11.02	9.79	6	386881	43	50218194
Gastric cancer	10.98	9.79	49	386838	2969	50215268
Acquired porphyria	10.97	9.79	5	386882	23	50218214
Porphyrins urine increased	10.97	9.79	5	386882	23	50218214
Cardiac valve sclerosis	10.97	9.79	5	386882	23	50218214
Flatulence	10.96	9.79	299	386588	29159	50189078
Peritonitis bacterial	10.94	9.79	67	386820	4594	50213643
Gastric cyst	10.93	9.79	8	386879	101	50218136
Graft versus host disease in skin	10.92	9.79	3	386884	2553	50215684
Renal neoplasm	10.89	9.79	25	386862	1059	50217178
Fibrosis	10.87	9.79	57	386830	3690	50214547
Menstruation irregular	10.86	9.79	19	386868	6143	50212094
Therapeutic product effect increased	10.84	9.79	24	386863	992	50217245
Nephrotic syndrome	10.84	9.79	68	386819	4702	50213535
Base excess decreased	10.84	9.79	7	386880	71	50218166
Pulmonary alveolar haemorrhage	10.82	9.79	60	386827	3967	50214270
Joint range of motion decreased	10.79	9.79	90	386797	18422	50199815
End stage renal disease	10.77	9.79	78	386809	5659	50212578
Chromaturia	10.76	9.79	164	386723	14426	50203811
Haemorrhagic erosive gastritis	10.76	9.79	12	386875	270	50217967
Osteoarthritis	10.76	9.79	422	386465	68184	50150053
Hypertensive urgency	10.75	9.79	10	386877	180	50218057
Urine flow decreased	10.73	9.79	11	386876	224	50218013
Disease recurrence	10.66	9.79	100	386787	19981	50198256
Dry eye	10.57	9.79	177	386710	31918	50186319
Glomerulonephritis	10.55	9.79	31	386856	1528	50216709
Peritoneal dialysis complication	10.53	9.79	26	386861	1155	50217082
Hyperparathyroidism primary	10.50	9.79	13	386874	328	50217909
Pulmonary hypoplasia	10.48	9.79	12	386875	278	50217959
Orthopnoea	10.48	9.79	77	386810	5612	50212625
Bacteriuria	10.41	9.79	19	386868	682	50217555
Small for dates baby	10.40	9.79	7	386880	3498	50214739
Neurofibrosarcoma	10.38	9.79	9	386878	147	50218090
Pneumonia viral	10.38	9.79	23	386864	6811	50211426
Mouth haemorrhage	10.37	9.79	82	386805	6114	50212123
Subarachnoid haemorrhage	10.35	9.79	127	386760	10649	50207588
Acute graft versus host disease	10.35	9.79	9	386878	3949	50214288
Therapeutic drug monitoring analysis not performed	10.33	9.79	19	386868	686	50217551
Renal cyst infection	10.30	9.79	8	386879	111	50218126
Sinoatrial block	10.26	9.79	20	386867	755	50217482
Oesophageal carcinoma recurrent	10.19	9.79	5	386882	28	50218209
Iliac artery occlusion	10.19	9.79	9	386878	151	50218086
Skin toxicity	10.11	9.79	9	386878	3904	50214333
Oesophageal atresia	10.09	9.79	16	386871	511	50217726
Periarticular disorder	10.07	9.79	6	386881	52	50218185
Oculomucocutaneous syndrome	10.07	9.79	8	386879	115	50218122
Haemorrhagic diathesis	10.07	9.79	58	386829	3890	50214347
Haematoma	10.06	9.79	305	386582	30205	50188032
Pneumothorax traumatic	10.04	9.79	9	386878	154	50218083
Oesophageal achalasia	10.01	9.79	14	386873	399	50217838
Carcinoid tumour of the stomach	9.99	9.79	9	386878	155	50218082
Cardiovascular disorder	9.95	9.79	123	386764	10331	50207906
Tracheo-oesophageal fistula	9.94	9.79	16	386871	518	50217719
Cerebrovascular insufficiency	9.93	9.79	7	386880	83	50218154
Psychomotor retardation	9.91	9.79	52	386835	3366	50214871
Interstitial granulomatous dermatitis	9.91	9.79	5	386882	30	50218207
Porphyrins stool increased	9.91	9.79	5	386882	30	50218207
Femoral artery dissection	9.91	9.79	5	386882	30	50218207
Congenital uterine anomaly	9.90	9.79	8	386879	118	50218119
Carcinoid tumour	9.90	9.79	12	386875	296	50217941
Contusion	9.87	9.79	731	386156	111452	50106785
Blood sodium abnormal	9.86	9.79	18	386869	646	50217591
Urate nephropathy	9.84	9.79	8	386879	119	50218118
Traumatic haemorrhage	9.84	9.79	15	386872	463	50217774
Vascular pseudoaneurysm	9.83	9.79	28	386859	1356	50216881
Drug screen positive	9.82	9.79	7	386880	3395	50214842
Change of bowel habit	9.80	9.79	33	386854	1751	50216486

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	600.81	11.01	2198	308502	88048	29175779
Gingival hypertrophy	390.47	11.01	234	310466	1431	29262396
Drug abuse	389.02	11.01	176	310524	79707	29184120
Off label use	337.69	11.01	1822	308878	298978	28964849
Drug ineffective	324.15	11.01	2362	308338	360808	28903019
Blood pressure inadequately controlled	261.49	11.01	210	310490	2176	29261651
Shock	214.94	11.01	601	310099	20803	29243024
Hypertensive crisis	181.77	11.01	309	310391	7539	29256288
Neutropenia	176.25	11.01	748	309952	130963	29132864
Foetal exposure during pregnancy	175.40	11.01	68	310632	33799	29230028
Product use in unapproved indication	173.40	11.01	412	310288	86463	29177364
Intentional overdose	168.95	11.01	827	309873	37701	29226126
Hypotension	165.88	11.01	2915	307785	191439	29072388
Febrile neutropenia	165	11.01	614	310086	111626	29152201
Oedema peripheral	158.72	11.01	1725	308975	101832	29161995
Treatment failure	148.58	11.01	103	310597	36836	29226991
Bradycardia	142.31	11.01	1177	309523	64452	29199375
Angioedema	139.15	11.01	684	310016	31231	29232596
Non-cardiogenic pulmonary oedema	138.99	11.01	85	310615	542	29263285
Acute kidney injury	136.88	11.01	3700	307000	261567	29002260
Death	133.96	11.01	2663	308037	339421	28924406
Distributive shock	121.57	11.01	93	310607	892	29262935
Blood pressure increased	116.07	11.01	1236	309464	72567	29191260
Syncope	109.12	11.01	1321	309379	80050	29183777
Cerebral infarction	103.42	11.01	523	310177	24152	29239675
Angina pectoris	93.66	11.01	556	310144	27294	29236533
Blood creatinine increased	90.22	11.01	1324	309376	83778	29180049
Thrombocytopenia	89.74	11.01	944	309756	133879	29129948
Drug resistance	82.78	11.01	63	310637	21477	29242350
Swollen tongue	82.42	11.01	300	310400	11966	29251861
Lip swelling	77.12	11.01	296	310404	12114	29251713
Premature baby	76.64	11.01	43	310657	17237	29246590
Hyperkalaemia	75.98	11.01	982	309718	60410	29203417
Hypokalaemia	75.28	11.01	833	309867	49370	29214457
Drug dependence	73.67	11.01	67	310633	20914	29242913
Renal impairment	71.69	11.01	1227	309473	80106	29183721
Blood pressure systolic increased	69.15	11.01	355	310345	16490	29247337
Cerebrovascular accident	69.13	11.01	1164	309536	75747	29188080
Chronic kidney disease	68.42	11.01	633	310067	35783	29228044
Rhabdomyolysis	66.37	11.01	951	309749	59857	29203970
Immune reconstitution inflammatory syndrome	65.90	11.01	4	310696	7798	29256029
Pancytopenia	65.23	11.01	559	310141	82609	29181218
Metabolic acidosis	63.54	11.01	640	310060	37022	29226805
Aggression	60.66	11.01	182	310518	35359	29228468
Sepsis	59.75	11.01	1097	309603	141585	29122242
Pyrexia	59.44	11.01	2445	308255	285177	28978650
Product use issue	58.79	11.01	309	310391	51135	29212692
Infusion related reaction	58.73	11.01	249	310451	43637	29220190
Dizziness	58.29	11.01	2492	308208	187192	29076635
Pathogen resistance	56.04	11.01	9	310691	8107	29255720
Suspected suicide	53.97	11.01	126	310574	3894	29259933
Exposure during pregnancy	51.74	11.01	13	310687	8541	29255286
Leukopenia	49.81	11.01	357	310343	54846	29208981
Rheumatoid arthritis	49.74	11.01	172	310528	31980	29231847
Septic shock	47.04	11.01	425	310275	62135	29201692
Mucosal inflammation	46.89	11.01	172	310528	31423	29232404
Progressive multifocal leukoencephalopathy	45.98	11.01	17	310683	8702	29255125
Vasoplegia syndrome	45.46	11.01	67	310633	1441	29262386
Nephrotic syndrome	45.27	11.01	158	310542	6170	29257657
Multiple organ dysfunction syndrome	45.21	11.01	434	310266	62682	29201145
Myalgia	44.28	11.01	1054	309646	72965	29190862
Myocardial depression	44.16	11.01	18	310682	38	29263789
Suicide attempt	44.04	11.01	550	310150	33560	29230267
Glycosylated haemoglobin increased	43.94	11.01	206	310494	9220	29254607
Proteinuria	43.54	11.01	300	310400	15504	29248323
Chronic pigmented purpura	43.42	11.01	22	310678	91	29263736
Gingival swelling	42.47	11.01	56	310644	1081	29262746
Lactic acidosis	42.22	11.01	495	310205	29752	29234075
Agitation	41.94	11.01	341	310359	50963	29212864
Pemphigoid	41.64	11.01	174	310526	7407	29256420
Renal cell carcinoma	41.49	11.01	126	310574	4570	29259257
Acute graft versus host disease	41.26	11.01	6	310694	5818	29258009
Palmar-plantar erythrodysaesthesia syndrome	41.16	11.01	281	310419	14478	29249349
Seizure	41.15	11.01	709	309991	92414	29171413
Renal artery stenosis	39.96	11.01	73	310627	1888	29261939
Pulmonary oedema	39.92	11.01	651	310049	42084	29221743
Myelosuppression	39.51	11.01	42	310658	12185	29251642
Cardiac failure congestive	39.47	11.01	1069	309631	75512	29188315
Drug ineffective for unapproved indication	39.41	11.01	55	310645	14159	29249668
Synovitis	39.16	11.01	34	310666	10856	29252971
Infective pulmonary exacerbation of cystic fibrosis	38.65	11.01	9	310691	6227	29257600
Tachycardia	38.55	11.01	532	310168	71878	29191949
Cytokine release syndrome	38.16	11.01	49	310651	13070	29250757
Atrioventricular block complete	38.02	11.01	176	310524	7835	29255992
Orthostatic hypotension	37.89	11.01	384	310316	22245	29241582
Suicidal ideation	37.74	11.01	212	310488	34504	29229323
Depression	37.71	11.01	648	310052	84499	29179328
Contraindicated product administered	37.70	11.01	85	310615	18181	29245646
C-reactive protein abnormal	37.53	11.01	11	310689	6525	29257302
Hypomagnesaemia	37.12	11.01	312	310388	17156	29246671
Sedation	36.74	11.01	80	310620	17325	29246502
Intentional product use issue	36.34	11.01	279	310421	42219	29221608
Haemophagocytic lymphohistiocytosis	36.33	11.01	34	310666	10470	29253357
Gastrointestinal tract mucosal pigmentation	36.32	11.01	31	310669	352	29263475
Bronchopulmonary aspergillosis	36.02	11.01	46	310654	12298	29251529
5-hydroxyindolacetic acid in urine increased	35.64	11.01	25	310675	207	29263620
Dermatomyositis	35.17	11.01	49	310651	999	29262828
Thalamus haemorrhage	34.96	11.01	46	310654	886	29262941
Interstitial lung disease	34.85	11.01	823	309877	56895	29206932
Hypertension	34.62	11.01	1527	309173	115087	29148740
Aspergillus infection	34.58	11.01	36	310664	10545	29253282
Hypoglycaemia	34.14	11.01	705	309995	47641	29216186
Post transplant lymphoproliferative disorder	33.90	11.01	8	310692	5485	29258342
Injection site pain	33.73	11.01	201	310499	32245	29231582
Nocturia	33.47	11.01	175	310525	8187	29255640
Infection	33.37	11.01	586	310114	76165	29187662
Bone marrow failure	32.98	11.01	162	310538	27287	29236540
Abnormal behaviour	32.32	11.01	129	310571	22998	29240829
Haematotoxicity	32.20	11.01	15	310685	6684	29257143
Cytomegalovirus infection	32.12	11.01	130	310570	23085	29240742
Renal failure	31.75	11.01	1537	309163	117062	29146765
Diastolic dysfunction	31.64	11.01	121	310579	4943	29258884
Gingival bleeding	31.54	11.01	143	310557	6310	29257517
Product monitoring error	31.34	11.01	79	310621	2566	29261261
Respiratory depression	31.23	11.01	59	310641	13464	29250363
Wrong technique in product usage process	30.95	11.01	198	310502	31230	29232597
Carotid artery stenosis	30.61	11.01	110	310590	4359	29259468
Multiple-drug resistance	30.13	11.01	3	310697	3897	29259930
Graft versus host disease	30.09	11.01	34	310666	9594	29254233
Irritability	30.05	11.01	125	310575	22027	29241800
Peripheral swelling	29.57	11.01	878	309822	62861	29200966
Plasmapheresis	29.07	11.01	25	310675	287	29263540
Polymyositis	29.06	11.01	51	310649	1277	29262550
Sinus bradycardia	28.92	11.01	215	310485	11388	29252439
Chronic graft versus host disease	28.89	11.01	4	310696	4025	29259802
Febrile bone marrow aplasia	28.89	11.01	21	310679	7330	29256497
Substance abuse	28.53	11.01	18	310682	6769	29257058
Primary hyperaldosteronism	28.37	11.01	14	310686	54	29263773
Therapeutic product effect decreased	28.27	11.01	187	310513	29264	29234563
Disease progression	27.68	11.01	652	310048	81264	29182563
Psychotic disorder	27.52	11.01	115	310585	20239	29243588
Mucormycosis	27.29	11.01	10	310690	5148	29258679
Cardiogenic shock	27.20	11.01	315	310385	18875	29244952
Electrocardiogram QRS complex prolonged	27.17	11.01	100	310600	4010	29259817
Vertebral osteophyte	26.97	11.01	13	310687	47	29263780
Myocardial infarction	26.96	11.01	1417	309283	108879	29154948
Palpitations	26.94	11.01	487	310213	32117	29231710
Sinusitis	26.85	11.01	231	310469	34119	29229708
Breath sounds abnormal	26.72	11.01	121	310579	5336	29258491
Macroglossia	26.65	11.01	26	310674	355	29263472
Transient ischaemic attack	26.60	11.01	367	310333	22903	29240924
Myelodysplastic syndrome	26.31	11.01	97	310603	17697	29246130
Eczema	26.29	11.01	241	310459	13585	29250242
Accelerated hypertension	26.27	11.01	21	310679	216	29263611
Pseudolymphoma	26.23	11.01	30	310670	497	29263330
Pelvic mass	26.13	11.01	20	310680	192	29263635
Neutrophil count decreased	25.79	11.01	313	310387	43254	29220573
Hyperplasia	25.77	11.01	30	310670	507	29263320
Periodontitis	25.55	11.01	58	310642	1759	29262068
Akathisia	25.54	11.01	20	310680	6722	29257105
Coma	25.47	11.01	278	310422	39172	29224655
Stenosis	25.45	11.01	42	310658	999	29262828
Staphylococcal infection	25.45	11.01	191	310509	29049	29234778
Loss of consciousness	25.44	11.01	985	309715	73071	29190756
Candida infection	25.23	11.01	79	310621	15146	29248681
Hypertensive heart disease	25.03	11.01	63	310637	2044	29261783
Metastatic renal cell carcinoma	24.87	11.01	59	310641	1843	29261984
Hyponatraemia	24.78	11.01	906	309794	66727	29197100
Orbital myositis	24.74	11.01	16	310684	114	29263713
Drug withdrawal syndrome	24.69	11.01	101	310599	17883	29245944
Atrioventricular block first degree	24.61	11.01	116	310584	5203	29258624
Blood mercury abnormal	24.36	11.01	19	310681	188	29263639
Acute hepatic failure	24.35	11.01	56	310644	11896	29251931
Diabetes mellitus inadequate control	24.35	11.01	214	310486	11920	29251907
Coronary artery disease	24.24	11.01	622	310078	43568	29220259
Condition aggravated	24.20	11.01	1273	309427	145022	29118805
Aortic dissection	23.98	11.01	67	310633	2317	29261510
Lymphadenopathy	23.56	11.01	160	310540	24889	29238938
Clear cell renal cell carcinoma	23.55	11.01	40	310660	975	29262852
Disease recurrence	23.37	11.01	87	310613	15827	29248000
Acute myocardial infarction	22.94	11.01	669	310031	47769	29216058
Adenovirus infection	22.90	11.01	9	310691	4438	29259389
Diabetic nephropathy	22.87	11.01	57	310643	1838	29261989
Erectile dysfunction	22.65	11.01	289	310411	17720	29246107
Carotid sinus syndrome	22.61	11.01	10	310690	28	29263799
Overdose	22.31	11.01	1039	309661	78780	29185047
Dystonia	22.11	11.01	43	310657	9706	29254121
Ventricular septal defect	22.06	11.01	5	310695	3524	29260303
Alcohol abuse	21.94	11.01	9	310691	4324	29259503
Tongue oedema	21.88	11.01	68	310632	2498	29261329
Hepatojugular reflux	21.78	11.01	26	310674	452	29263375
Hospitalisation	21.65	11.01	346	310354	45642	29218185
Maternal drugs affecting foetus	21.54	11.01	7	310693	3886	29259941
Dyskinesia	21.53	11.01	123	310577	19938	29243889
Drug intolerance	21.46	11.01	368	310332	48011	29215816
Cytomegalovirus chorioretinitis	21.46	11.01	4	310696	3234	29260593
Asthma	21.45	11.01	486	310214	33363	29230464
Carotid arteriosclerosis	21.45	11.01	47	310653	1391	29262436
Obstructive airways disorder	21.45	11.01	193	310507	10823	29253004
Hypoinsulinaemia	21.40	11.01	6	310694	0	29263827
Leukaemoid reaction	21.24	11.01	13	310687	83	29263744
Drug use disorder	21.09	11.01	5	310695	3417	29260410
Device issue	20.68	11.01	31	310669	7749	29256078
Gout	20.68	11.01	270	310430	16641	29247186
Pulmonary embolism	20.66	11.01	629	310071	75905	29187922
Hyperdynamic left ventricle	20.65	11.01	14	310686	109	29263718
Cytomegalovirus infection reactivation	20.56	11.01	5	310695	3359	29260468
Lung diffusion test decreased	20.53	11.01	28	310672	559	29263268
Psoriatic arthropathy	20.49	11.01	82	310618	14609	29249218
Therapeutic product effect incomplete	20.47	11.01	290	310410	39015	29224812
Renal disorder	20.28	11.01	342	310358	22253	29241574
Therapy partial responder	20.24	11.01	15	310685	5184	29258643
Lipodystrophy acquired	20.13	11.01	4	310696	3090	29260737
Arthropathy	20.11	11.01	138	310562	21416	29242411
Status epilepticus	20.09	11.01	53	310647	10741	29253086
Product dose omission issue	20.08	11.01	818	309882	95565	29168262
Blood creatine phosphokinase increased	19.98	11.01	564	310136	40080	29223747
Apparent death	19.93	11.01	6	310694	3498	29260329
Ear infection	19.91	11.01	34	310666	8066	29255761
Fall	19.87	11.01	2139	308561	175039	29088788
Lacunar infarction	19.83	11.01	70	310630	2749	29261078
Pseudomonas infection	19.66	11.01	54	310646	10798	29253029
Neurotoxicity	19.48	11.01	83	310617	14530	29249297
No adverse event	19.39	11.01	106	310594	17372	29246455
Pneumonia	19.37	11.01	3011	307689	317161	28946666
Electrocardiogram Q wave abnormal	19.29	11.01	20	310680	295	29263532
Lymphocele	19.27	11.01	43	310657	1289	29262538
Brain stem infarction	19.26	11.01	39	310661	1091	29262736
Blood glucose increased	19.20	11.01	780	309920	58204	29205623
Bone erosion	19.19	11.01	3	310697	2757	29261070
Microalbuminuria	19.17	11.01	29	310671	639	29263188
Dyspnoea	19.02	11.01	3798	306902	322934	28940893
Venoocclusive liver disease	18.94	11.01	27	310673	6890	29256937
Atrioventricular block	18.91	11.01	132	310568	6850	29256977
Small for dates baby	18.83	11.01	7	310693	3572	29260255
Graft versus host disease in skin	18.83	11.01	6	310694	3373	29260454
Haemorrhage subcutaneous	18.76	11.01	57	310643	2068	29261759
Maternal exposure during pregnancy	18.66	11.01	10	310690	4113	29259714
Mouth swelling	18.60	11.01	47	310653	1529	29262298
Blood pressure diastolic decreased	18.58	11.01	132	310568	6890	29256937
Congenital hiatus hernia	18.45	11.01	23	310677	419	29263408
Zoonotic bacterial infection	18.43	11.01	10	310690	49	29263778
Chills	18.27	11.01	590	310110	70710	29193117
Atheroembolism	18.15	11.01	17	310683	220	29263607
Heart rate decreased	18.15	11.01	365	310335	24547	29239280
Paranoia	18.00	11.01	49	310651	9828	29253999
Acute myeloid leukaemia	17.85	11.01	101	310599	16412	29247415
Nipple inflammation	17.82	11.01	10	310690	53	29263774
Left ventricular hypertrophy	17.73	11.01	126	310574	6577	29257250
Intentional self-injury	17.73	11.01	69	310631	12392	29251435
Diffuse large B-cell lymphoma recurrent	17.66	11.01	3	310697	2594	29261233
Melaena	17.44	11.01	440	310260	30736	29233091
Mydriasis	17.42	11.01	23	310677	6062	29257765
Bundle branch block	17.31	11.01	31	310669	789	29263038
Hepatic failure	17.30	11.01	230	310470	31282	29232545
Skin toxicity	17.28	11.01	9	310691	3762	29260065
Hyperlipidaemia	17.10	11.01	205	310495	12385	29251442
Angina unstable	17.06	11.01	182	310518	10683	29253144
Dysmorphism	17.06	11.01	5	310695	2966	29260861
Haemodynamic instability	17.05	11.01	144	310556	7929	29255898
Multiple sclerosis relapse	17.05	11.01	62	310638	11357	29252470
Product substitution issue	17.00	11.01	159	310541	9013	29254814
Liver carcinoma ruptured	16.98	11.01	14	310686	151	29263676
Tenosynovitis	16.97	11.01	9	310691	3724	29260103
Milk-alkali syndrome	16.91	11.01	24	310676	498	29263329
Fungal infection	16.88	11.01	80	310620	13605	29250222
Hypertensive emergency	16.88	11.01	31	310669	805	29263022
Peripheral arterial occlusive disease	16.84	11.01	101	310599	4975	29258852
Obsessive-compulsive disorder	16.80	11.01	14	310686	4562	29259265
Myopathy	16.80	11.01	177	310523	10356	29253471
Hyperuricaemia	16.80	11.01	127	310573	6762	29257065
Vomiting	16.77	11.01	1963	308737	210297	29053530
Diabetic neuropathy	16.75	11.01	81	310619	3672	29260155
Dyspnoea exertional	16.74	11.01	502	310198	35988	29227839
Deep vein thrombosis	16.67	11.01	467	310233	56932	29206895
Pollakiuria	16.66	11.01	260	310440	16656	29247171
Cognitive disorder	16.64	11.01	162	310538	23337	29240490
Fibrillary glomerulonephritis	16.60	11.01	9	310691	44	29263783
Stomatitis	16.56	11.01	282	310418	36831	29226996
Pharyngeal oedema	16.48	11.01	110	310590	5624	29258203
Swelling face	16.47	11.01	303	310397	20047	29243780
Acidosis	16.39	11.01	165	310535	9540	29254287
Neuroleptic malignant syndrome	16.28	11.01	101	310599	16047	29247780
Epiglottic oedema	16.26	11.01	14	310686	161	29263666
Haemodialysis	16.22	11.01	168	310532	9786	29254041
Nasal crusting	16.18	11.01	20	310680	361	29263466
Pericardial disease	16.14	11.01	20	310680	362	29263465
Epstein-Barr virus infection	16.13	11.01	28	310672	6601	29257226
Duodenal ulcer haemorrhage	16.08	11.01	91	310609	4388	29259439
Cardiomegaly	16.04	11.01	218	310482	13558	29250269
Cytomegalovirus viraemia	16.02	11.01	26	310674	6294	29257533
Drug eruption	15.99	11.01	256	310444	16485	29247342
Chest pain	15.97	11.01	1375	309325	110598	29153229
Serotonin syndrome	15.91	11.01	113	310587	17399	29246428
Dermatitis infected	15.89	11.01	11	310689	89	29263738
Pericardial haemorrhage	15.88	11.01	67	310633	2864	29260963
Eyelid oedema	15.86	11.01	93	310607	4543	29259284
Tricuspid valve incompetence	15.80	11.01	146	310554	8248	29255579
Hypersensitivity vasculitis	15.78	11.01	72	310628	3185	29260642
Presyncope	15.73	11.01	247	310453	15842	29247985
Kidney small	15.70	11.01	9	310691	50	29263777
Ventricular hypertrophy	15.55	11.01	87	310613	4177	29259650
Osteonecrosis	15.55	11.01	81	310619	13438	29250389
Hyperglycaemia	15.54	11.01	471	310229	33816	29230011
Prescription drug used without a prescription	15.50	11.01	39	310661	1265	29262562
Embolic stroke	15.50	11.01	77	310623	3529	29260298
Neuropathy peripheral	15.39	11.01	600	310100	70427	29193400
White blood cell count decreased	15.39	11.01	717	309983	82645	29181182
Tremor	15.34	11.01	624	310076	72914	29190913
Musculoskeletal stiffness	15.32	11.01	289	310411	37169	29226658
Viral infection	15.26	11.01	92	310608	14718	29249109
Pain	15.17	11.01	1573	309127	169859	29093968
Hepatic neoplasm	15.05	11.01	48	310652	1788	29262039
Hydronephrosis	15.02	11.01	149	310551	8581	29255246
Intervertebral disc displacement	14.97	11.01	12	310688	124	29263703
Tricuspid valve calcification	14.94	11.01	5	310695	4	29263823
Lymphoma	14.91	11.01	53	310647	9775	29254052
Cerebral haemorrhage	14.87	11.01	434	310266	30992	29232835
Low density lipoprotein decreased	14.84	11.01	33	310667	987	29262840
Putamen haemorrhage	14.80	11.01	15	310685	215	29263612
Dyspnoea at rest	14.80	11.01	70	310630	3144	29260683
Malignant neoplasm progression	14.71	11.01	630	310070	73229	29190598
Band neutrophil percentage decreased	14.62	11.01	6	310694	13	29263814
Graft versus host disease in gastrointestinal tract	14.60	11.01	8	310692	3250	29260577
High density lipoprotein decreased	14.54	11.01	66	310634	2913	29260914
Atrial septal defect	14.50	11.01	31	310669	6758	29257069
Blood uric acid increased	14.44	11.01	107	310593	5661	29258166
Bundle branch block left	14.43	11.01	100	310600	5177	29258650
Cachexia	14.40	11.01	28	310672	6321	29257506
Product administered to patient of inappropriate age	14.30	11.01	5	310695	2650	29261177
Blood pressure abnormal	14.28	11.01	121	310579	6669	29257158
Mucosal membrane hyperplasia	14.27	11.01	4	310696	0	29263827
Ventricular compliance decreased	14.27	11.01	4	310696	0	29263827
Left ventricular enlargement	14.22	11.01	25	310675	627	29263200
Discomfort	14.19	11.01	226	310474	14537	29249290
Blood cholinesterase decreased	14.17	11.01	11	310689	108	29263719
Muscle rigidity	14.11	11.01	51	310649	9360	29254467
Hepatic enzyme increased	14.06	11.01	260	310440	33539	29230288
Euphoric mood	14.06	11.01	18	310682	4807	29259020
Hypospadias	14.00	11.01	7	310693	2995	29260832
Polypectomy	13.98	11.01	22	310678	502	29263325
Device leakage	13.91	11.01	16	310684	4479	29259348
Herpes zoster	13.84	11.01	227	310473	29825	29234002
Gastric cancer	13.80	11.01	92	310608	4702	29259125
Lacrimal disorder	13.79	11.01	17	310683	306	29263521
Body temperature decreased	13.78	11.01	172	310528	10492	29253335
Blood aldosterone increased	13.77	11.01	6	310694	16	29263811
Prostate cancer recurrent	13.76	11.01	30	310670	885	29262942
Encephalitis toxic	13.72	11.01	16	310684	271	29263556
Giant cell arteritis	13.63	11.01	27	310673	743	29263084
Crying	13.58	11.01	22	310678	5329	29258498
Neonatal respiratory distress syndrome	13.57	11.01	12	310688	3798	29260029
Hepatocellular carcinoma	13.54	11.01	123	310577	6915	29256912
Thromboangiitis obliterans	13.51	11.01	6	310694	17	29263810
Unintentional medical device removal	13.51	11.01	4	310696	2357	29261470
Hypocalcaemia	13.50	11.01	298	310402	20367	29243460
Post-traumatic amnestic disorder	13.47	11.01	8	310692	48	29263779
Suspected suicide attempt	13.46	11.01	11	310689	117	29263710
Cutaneous lupus erythematosus	13.46	11.01	26	310674	702	29263125
Migraine	13.45	11.01	76	310624	12354	29251473
Intentional product misuse	13.39	11.01	270	310430	34391	29229436
Histology abnormal	13.36	11.01	16	310684	279	29263548
Mitral valve incompetence	13.35	11.01	205	310495	13088	29250739
Nausea	13.33	11.01	2760	307940	286495	28977332
Oedema	13.32	11.01	536	310164	39947	29223880
Allergy to animal	13.28	11.01	15	310685	245	29263582
Device use error	13.28	11.01	3	310697	2119	29261708
Product solubility abnormal	13.27	11.01	20	310680	439	29263388
Toxic nodular goitre	13.27	11.01	6	310694	18	29263809
Osteoporosis	13.26	11.01	63	310637	10706	29253121
Dysphagia	13.24	11.01	458	310242	54468	29209359
Pulmonary valve disease	13.23	11.01	16	310684	282	29263545
Lipoma	13.21	11.01	39	310661	1392	29262435
Nodal rhythm	13.18	11.01	37	310663	1283	29262544
Lymphocyte count decreased	13.16	11.01	134	310566	19137	29244690
Atrioventricular block second degree	13.16	11.01	67	310633	3101	29260726
Sex hormone binding globulin increased	13.14	11.01	5	310695	8	29263819
Generalised oedema	13.13	11.01	177	310523	10988	29252839
Acute coronary syndrome	13.13	11.01	192	310508	12133	29251694
Pruritus	13.12	11.01	1411	309289	115438	29148389
Pelvic cyst	13.11	11.01	7	310693	33	29263794
Hair colour changes	13.10	11.01	42	310658	1569	29262258
Bacteraemia	13.10	11.01	109	310591	16214	29247613
Malaise	13.10	11.01	1890	308810	157712	29106115
Retinopathy hypertensive	13.05	11.01	15	310685	250	29263577
Multiple sclerosis	13.03	11.01	24	310676	5530	29258297
Hepatic function abnormal	12.96	11.01	520	310180	38739	29225088
Respiratory arrest	12.96	11.01	192	310508	25641	29238186
Hyperthermia	12.92	11.01	53	310647	9377	29254450
Injection site reaction	12.88	11.01	67	310633	11121	29252706
Thrombotic stroke	12.86	11.01	15	310685	254	29263573
Hyperammonaemia	12.82	11.01	25	310675	5638	29258189
Nephrogenic systemic fibrosis	12.80	11.01	78	310622	3864	29259963
Thirst	12.78	11.01	114	310586	6377	29257450
Guillain-Barre syndrome	12.76	11.01	94	310606	4964	29258863
Hypertensive encephalopathy	12.74	11.01	17	310683	332	29263495
Blood urea increased	12.69	11.01	386	310314	27726	29236101
Low birth weight baby	12.64	11.01	32	310668	6576	29257251
Aortic aneurysm	12.64	11.01	110	310590	6110	29257717
Therapy non-responder	12.48	11.01	239	310461	30672	29233155
Macrophages increased	12.35	11.01	12	310688	163	29263664
Drug screen positive	12.34	11.01	13	310687	3788	29260039
Hyperbilirubinaemia	12.31	11.01	99	310601	14835	29248992
Blood potassium decreased	12.29	11.01	233	310467	15501	29248326
Urogenital haemorrhage	12.29	11.01	20	310680	470	29263357
Enterococcal infection	12.27	11.01	45	310655	8223	29255604
Incorrect route of product administration	12.26	11.01	65	310635	10736	29253091
Fracture displacement	12.26	11.01	8	310692	58	29263769
Sinonasal obstruction	12.19	11.01	6	310694	23	29263804
Thrombotic cerebral infarction	12.17	11.01	16	310684	308	29263519
Herbal interaction	12.17	11.01	16	310684	308	29263519
Drug level decreased	12.15	11.01	30	310670	6217	29257610
Brain contusion	12.09	11.01	25	310675	710	29263117
Dialysis	12.07	11.01	162	310538	10046	29253781
Generalised bullous fixed drug eruption	12.06	11.01	4	310696	3	29263824
Ventricular hyperkinesia	12.01	11.01	13	310687	202	29263625
Uveitis	12.01	11.01	28	310672	5919	29257908
Primary hypoparathyroidism	11.99	11.01	6	310694	24	29263803
Flour sensitivity	11.99	11.01	6	310694	24	29263803
Lung hernia	11.93	11.01	8	310692	61	29263766
Body temperature increased	11.88	11.01	96	310604	14369	29249458
Respiratory failure	11.87	11.01	869	309831	96262	29167565
Peripheral artery stenosis	11.87	11.01	27	310673	820	29263007
Helicobacter gastritis	11.84	11.01	31	310669	1031	29262796
Antipsychotic drug level increased	11.81	11.01	10	310690	3233	29260594
Peripheral artery occlusion	11.78	11.01	38	310662	1424	29262403
Renal artery thrombosis	11.75	11.01	15	310685	280	29263547
Pneumocystis jirovecii pneumonia	11.74	11.01	116	310584	16663	29247164
Left atrial enlargement	11.68	11.01	25	310675	728	29263099
Lymphomatoid papulosis	11.63	11.01	12	310688	176	29263651
Full blood count abnormal	11.62	11.01	222	310478	14791	29249036
Noninfective gingivitis	11.61	11.01	14	310686	246	29263581
Therapeutic response decreased	11.60	11.01	186	310514	24525	29239302
Sinus node dysfunction	11.57	11.01	73	310627	3661	29260166
Pericarditis uraemic	11.56	11.01	5	310695	13	29263814
Arterial stenosis	11.55	11.01	32	310668	1101	29262726
Anxiety	11.55	11.01	757	309943	84608	29179219
Diffuse large B-cell lymphoma	11.54	11.01	31	310669	6245	29257582
Forced vital capacity decreased	11.49	11.01	23	310677	638	29263189
Hepatotoxicity	11.49	11.01	126	310574	17741	29246086
Drug abuser	11.44	11.01	14	310686	3813	29260014
Pneumonia cytomegaloviral	11.43	11.01	7	310693	2675	29261152
Intercepted product preparation error	11.43	11.01	5	310695	2312	29261515
Lung operation	11.43	11.01	8	310692	66	29263761
Arteriosclerosis	11.41	11.01	161	310539	10095	29253732
Prerenal failure	11.40	11.01	43	310657	1745	29262082
Strongyloidiasis	11.39	11.01	5	310695	2307	29261520
Gingivitis	11.38	11.01	61	310639	2881	29260946
Ultrafiltration failure	11.35	11.01	11	310689	149	29263678
Hypertensive nephropathy	11.34	11.01	18	310682	414	29263413
Occult blood	11.34	11.01	21	310679	549	29263278
Red blood cell sedimentation rate abnormal	11.31	11.01	5	310695	2298	29261529
Yellow skin	11.31	11.01	45	310655	1873	29261954
Hepatitis	11.30	11.01	152	310548	20631	29243196
Retinal vascular thrombosis	11.24	11.01	8	310692	68	29263759
Renal transplant	11.23	11.01	40	310660	1578	29262249
Brain abscess	11.22	11.01	7	310693	2648	29261179
Decreased appetite	11.19	11.01	1715	308985	143627	29120200
Intestinal stenosis	11.17	11.01	3	310697	1885	29261942
Large intestine polyp	11.16	11.01	111	310589	6398	29257429
Cytomegalovirus colitis	11.16	11.01	6	310694	2463	29261364
Osmolar gap abnormal	11.12	11.01	6	310694	29	29263798
Oliguria	11.10	11.01	123	310577	7289	29256538
Gastric ulcer haemorrhage	11.10	11.01	89	310611	4825	29259002
Stasis dermatitis	11.07	11.01	24	310676	705	29263122
Mean platelet volume increased	11.06	11.01	18	310682	423	29263404
Mycobacterium avium complex infection	11.03	11.01	5	310695	2264	29261563
Palatal oedema	11.03	11.01	24	310676	707	29263120

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Completed suicide	1173.37	10.37	4577	580316	219837	63694002
Drug ineffective	882.41	10.37	4277	580616	835970	63077869
Hypotension	672.34	10.37	5815	579078	375159	63538680
Off label use	650.08	10.37	3243	581650	629563	63284276
Shock	638.33	10.37	1201	583692	37039	63876800
Gingival hypertrophy	631.85	10.37	362	584531	2385	63911454
Synovitis	562.29	10.37	108	584785	98982	63814857
Acute kidney injury	515.05	10.37	6278	578615	442962	63470877
Maternal exposure during pregnancy	476.11	10.37	139	584754	95745	63818094
Drug abuse	455.36	10.37	322	584571	132052	63781787
Treatment failure	453.26	10.37	247	584646	116569	63797270
Contraindicated product administered	439.18	10.37	214	584679	107615	63806224
Anti-cyclic citrullinated peptide antibody positive	431.59	10.37	3	584890	49559	63864280
Non-cardiogenic pulmonary oedema	425.63	10.37	217	584676	1091	63912748
Drug intolerance	425.13	10.37	654	584239	187338	63726501
Infusion related reaction	417.00	10.37	527	584366	163940	63749899
Bradycardia	410.89	10.37	2138	582755	116081	63797758
Blood pressure inadequately controlled	408.15	10.37	360	584533	5024	63908815
Hand deformity	397.84	10.37	50	584843	62721	63851118
Oedema peripheral	391.05	10.37	3250	581643	207067	63706772
Pemphigus	385.57	10.37	48	584845	60653	63853186
Systemic lupus erythematosus	368.29	10.37	122	584771	77490	63836349
Intentional overdose	364.81	10.37	1700	583193	88244	63825595
Therapeutic product effect decreased	348.65	10.37	319	584574	115032	63798807
Arthropathy	345.33	10.37	352	584541	120615	63793224
Hyponatraemia	316.09	10.37	2366	582527	145973	63767866
Pericarditis	311.47	10.37	90	584803	62426	63851413
Angioedema	300.61	10.37	1234	583659	60587	63853252
Rheumatoid arthritis	298.83	10.37	653	584240	163641	63750198
Cerebrovascular accident	279.96	10.37	2171	582722	135412	63778427
Glossodynia	265.52	10.37	127	584766	64569	63849270
Orthostatic hypotension	263.03	10.37	977	583916	45761	63868078
Blood pressure increased	261.90	10.37	2552	582341	170000	63743839
Distributive shock	254.69	10.37	177	584716	1698	63912141
Hypertensive crisis	245.58	10.37	524	584369	17724	63896115
Rheumatoid factor positive	244.44	10.37	19	584874	34919	63878920
Hyperkalaemia	241.38	10.37	1658	583235	99471	63814368
Hepatic enzyme increased	240.80	10.37	511	584382	129432	63784407
Renal impairment	240.41	10.37	2067	582826	132950	63780889
Alopecia	240.34	10.37	738	584155	164952	63748887
Product use in unapproved indication	237.23	10.37	814	584079	175804	63738035
Fall	233.21	10.37	5178	579715	411648	63502191
Vasoplegia syndrome	227.91	10.37	194	584699	2573	63911266
Metabolic acidosis	221.83	10.37	1247	583646	69711	63844128
Product use issue	217.72	10.37	679	584214	151036	63762803
Exposure during pregnancy	216.03	10.37	231	584662	77444	63836395
C-reactive protein abnormal	214.40	10.37	12	584881	29035	63884804
Hypersensitivity	212.17	10.37	987	583906	195465	63718374
Sleep disorder due to general medical condition, insomnia type	203.12	10.37	8	584885	26262	63887577
Lactic acidosis	201.84	10.37	1094	583799	60316	63853523
Pain	200.88	10.37	3673	581220	549838	63364001
Syncope	197.08	10.37	2242	582651	155393	63758446
Neutropenia	196.13	10.37	1319	583574	238305	63675534
Hypokalaemia	191.81	10.37	1817	583076	120086	63793753
Helicobacter infection	189.67	10.37	56	584837	38306	63875533
Febrile neutropenia	185.82	10.37	972	583921	186685	63727154
Sinusitis	185.64	10.37	688	584205	145240	63768599
Duodenal ulcer perforation	185.56	10.37	43	584850	34582	63879257
Wound	181.56	10.37	257	584636	76220	63837619
Cerebral infarction	175.40	10.37	788	584105	40256	63873583
Folliculitis	172.23	10.37	32	584861	30045	63883794
Blood creatinine increased	170.50	10.37	1933	582960	133849	63779990
Cardiac failure congestive	167.62	10.37	1867	583026	128713	63785126
Hypoglycaemia	162.99	10.37	1382	583511	88510	63825329
Dizziness	162.97	10.37	5077	579816	425086	63488753
Rhabdomyolysis	156.30	10.37	1391	583502	90335	63823504
Arthralgia	155.50	10.37	2950	581943	439310	63474529
Infection	146.09	10.37	1028	583865	183852	63729987
Angina pectoris	142.69	10.37	795	584098	44286	63869553
Injection site pain	139.87	10.37	528	584365	110880	63802959
Muscle injury	139.37	10.37	34	584859	26403	63887436
Therapeutic product effect incomplete	138.14	10.37	478	584415	103004	63810835
Abortion spontaneous	137.19	10.37	30	584863	25113	63888726
Swollen tongue	136.03	10.37	653	584240	34301	63879538
Condition aggravated	134.30	10.37	2473	582420	369953	63543886
Injection site erythema	131.46	10.37	278	584615	70522	63843317
Pregnancy	128.89	10.37	18	584875	20847	63892992
Myocardial infarction	128.56	10.37	2166	582727	163655	63750184
Musculoskeletal stiffness	127.68	10.37	628	584265	122578	63791261
Pyrexia	126.51	10.37	3981	580912	554663	63359176
Red blood cell sedimentation rate abnormal	125.95	10.37	5	584888	16301	63897538
Irritable bowel syndrome	123.11	10.37	95	584798	37274	63876565
Chronic kidney disease	116.61	10.37	912	583981	57007	63856832
Device expulsion	115.77	10.37	25	584868	21111	63892728
Renal failure	114.89	10.37	2299	582594	179389	63734450
Atrioventricular block complete	114.76	10.37	339	584554	14079	63899760
Drug resistance	114.67	10.37	90	584803	35012	63878827
Injection site reaction	113.56	10.37	154	584739	46510	63867329
Overdose	113.18	10.37	2055	582838	157511	63756328
Impaired healing	108.50	10.37	242	584651	60231	63853608
Discomfort	106.99	10.37	375	584518	80503	63833336
Lower respiratory tract infection	104.64	10.37	471	584422	94143	63819696
Coronary artery disease	104.24	10.37	919	583974	59514	63854325
Suicide attempt	104.08	10.37	1043	583850	69964	63843875
Intentional product use issue	102.34	10.37	480	584413	94884	63818955
Creatinine renal clearance decreased	98.95	10.37	322	584571	14099	63899740
Cardiogenic shock	98.75	10.37	566	584327	31861	63881978
Sinus bradycardia	98.16	10.37	440	584453	22453	63891386
Abdominal discomfort	97.77	10.37	1119	583774	181203	63732636
Atrial fibrillation	97.75	10.37	2133	582760	168956	63744883
Pulmonary oedema	97.34	10.37	1117	583776	77557	63836282
Neurologic neglect syndrome	97.13	10.37	95	584798	1523	63912316
Toxicity to various agents	94.48	10.37	4114	580779	359399	63554440
Stomatitis	94.28	10.37	594	584299	109011	63804828
Hypomagnesaemia	92.82	10.37	619	584274	36757	63877082
Swelling	91.61	10.37	969	583924	159249	63754590
Drug dependence	91.57	10.37	100	584793	33212	63880627
Atrioventricular block first degree	89.88	10.37	257	584636	10477	63903362
Suspected suicide	89.44	10.37	224	584669	8430	63905409
Blood pressure systolic increased	87.35	10.37	756	584137	48697	63865142
Depressed level of consciousness	87.17	10.37	1125	583768	80311	63833528
Proteinuria	87.12	10.37	488	584405	27235	63886604
Fibromyalgia	86.86	10.37	118	584775	35613	63878226
Joint swelling	84.93	10.37	1407	583486	213975	63699864
Sedation complication	83.89	10.37	245	584648	10109	63903730
Carotid artery thrombosis	81.90	10.37	91	584802	1704	63912135
Hypertensive emergency	81.62	10.37	102	584791	2174	63911665
Acute myocardial infarction	81.43	10.37	979	583914	68739	63845100
Psoriatic arthropathy	81.13	10.37	169	584724	43112	63870727
Lip swelling	79.58	10.37	529	584364	31378	63882461
Balance disorder	79.01	10.37	1133	583760	82793	63831046
Wrong technique in product usage process	78.91	10.37	312	584581	64662	63849177
Pemphigoid	78.58	10.37	278	584615	12708	63901131
Decreased appetite	76.74	10.37	3200	581693	278089	63635750
Migraine	76.74	10.37	300	584593	62377	63851462
Anuria	76.49	10.37	358	584535	18606	63895233
Live birth	75.88	10.37	7	584886	11197	63902642
Renin increased	75.33	10.37	38	584855	186	63913653
Ill-defined disorder	75.23	10.37	181	584712	43871	63869968
Rash	74.87	10.37	3397	581496	455152	63458687
Pathogen resistance	72.56	10.37	13	584880	12530	63901309
Intentional self-injury	71.53	10.37	95	584798	28949	63884890
Renal artery stenosis	70.35	10.37	109	584784	2860	63910979
Transient ischaemic attack	70.14	10.37	660	584233	43522	63870317
Injection site pruritus	69.81	10.37	149	584744	37677	63876162
Infective pulmonary exacerbation of cystic fibrosis	68.73	10.37	12	584881	11784	63902055
Hypertension	68.13	10.37	2938	581955	256323	63657516
Hyperglycaemia	68.11	10.37	849	584044	60119	63853720
Injection site swelling	67.43	10.37	174	584719	41179	63872660
Septic shock	66.37	10.37	623	584270	104814	63809025
Weight increased	65.87	10.37	1453	583440	211895	63701944
Diabetes mellitus inadequate control	65.47	10.37	373	584520	20948	63892891
Rheumatoid nodule	65.27	10.37	17	584876	12634	63901205
Sprue-like enteropathy	64.75	10.37	62	584831	967	63912872
Drug interaction	64.24	10.37	3952	580941	358131	63555708
Chronic pigmented purpura	64.03	10.37	32	584861	153	63913686
Immune reconstitution inflammatory syndrome	63.88	10.37	17	584876	12453	63901386
Gastrointestinal disorder	63.59	10.37	514	584379	89195	63824644
Cytomegalovirus infection	62.61	10.37	154	584739	37045	63876794
Asthenia	61.80	10.37	4592	580301	423452	63490387
Gingival swelling	61.55	10.37	120	584773	3800	63910039
Thrombocytopenia	61.38	10.37	1552	583341	222249	63691590
Injection site bruising	60.89	10.37	151	584742	36222	63877617
Carotid artery stenosis	59.70	10.37	183	584710	7758	63906081
Loss of consciousness	59.40	10.37	1764	583129	146601	63767238
Glycosylated haemoglobin increased	59.27	10.37	295	584598	15724	63898115
Dyspnoea	59.24	10.37	7410	577483	711264	63202575
Tenosynovitis	58.99	10.37	17	584876	11816	63902023
Leukopenia	58.37	10.37	611	584282	100631	63813208
Hemiplegia	58.23	10.37	250	584643	12518	63901321
Gingival bleeding	58.15	10.37	278	584615	14576	63899263
Mucosal inflammation	57.57	10.37	332	584561	62252	63851587
Product monitoring error	57.23	10.37	142	584751	5312	63908527
Bone marrow failure	57.12	10.37	232	584661	47720	63866119
Aortic dissection	57.06	10.37	108	584785	3344	63910495
Atrioventricular block	56.93	10.37	238	584655	11777	63902062
Myocardial depression	55.81	10.37	42	584851	461	63913378
Left ventricular hypertrophy	55.38	10.37	201	584692	9305	63904534
Blood calcium decreased	55.13	10.37	409	584484	25145	63888694
Melaena	54.89	10.37	734	584159	52814	63861025
Nasopharyngitis	54.76	10.37	1356	583537	194717	63719122
Blood pressure decreased	54.51	10.37	1091	583802	85108	63828731
Blood creatine phosphokinase increased	54.10	10.37	788	584105	57770	63856069
Myelosuppression	53.69	10.37	83	584810	23747	63890092
Product prescribing error	53.58	10.37	522	584371	34747	63879092
Palpitations	53.50	10.37	1283	583610	103205	63810634
Haematotoxicity	53.38	10.37	25	584868	12871	63900968
Body temperature increased	52.61	10.37	164	584729	36502	63877337
Circulatory collapse	52.60	10.37	502	584391	33230	63880609
Acute graft versus host disease	49.23	10.37	11	584882	9073	63904766
Angina unstable	49.09	10.37	273	584620	15194	63898645
Myalgia	48.93	10.37	1829	583064	156788	63757051
Bone erosion	48.74	10.37	22	584871	11573	63902266
Injection site warmth	48.59	10.37	31	584862	13431	63900408
Immunodeficiency	48.20	10.37	45	584848	16079	63897760
Nocturia	48.17	10.37	215	584678	10950	63902889
Hyperdynamic left ventricle	48.01	10.37	31	584862	260	63913579
Interstitial lung disease	47.62	10.37	1192	583701	96540	63817299
Hypertensive heart disease	47.50	10.37	106	584787	3698	63910141
Oliguria	47.41	10.37	259	584634	14317	63899522
Multiple sclerosis relapse	47.15	10.37	202	584691	40933	63872906
Renal cell carcinoma	47.14	10.37	142	584751	5962	63907877
Blood urea increased	46.83	10.37	609	584284	43544	63870295
Adjustment disorder	46.76	10.37	87	584806	2658	63911181
Pseudolymphoma	46.66	10.37	52	584841	977	63912862
Hip arthroplasty	46.56	10.37	76	584817	21275	63892564
Hepatic function abnormal	46.51	10.37	831	584062	63482	63850357
Nephrotic syndrome	46.50	10.37	191	584702	9376	63904463
Aggression	45.96	10.37	239	584654	45993	63867846
Lacunar infarction	45.88	10.37	132	584761	5400	63908439
Subacute cutaneous lupus erythematosus	45.56	10.37	91	584802	2934	63910905
Post transplant lymphoproliferative disorder	45.26	10.37	15	584878	9529	63904310
Aspergillus infection	45.20	10.37	49	584844	16330	63897509
Foot deformity	44.85	10.37	50	584843	16454	63897385
Therapeutic response decreased	44.77	10.37	283	584610	51905	63861934
Hyperlipidaemia	44.70	10.37	359	584534	22617	63891222
Cytokine release syndrome	44.62	10.37	75	584818	20754	63893085
Renal disorder	44.57	10.37	504	584389	34861	63878978
Ear infection	44.19	10.37	91	584802	23313	63890526
Haemorrhage subcutaneous	44.15	10.37	112	584781	4249	63909590
Haematochezia	43.96	10.37	846	584047	65527	63848312
Nodal rhythm	43.94	10.37	87	584806	2787	63911052
Loss of personal independence in daily activities	43.94	10.37	432	584461	72022	63841817
Hepatotoxicity	43.53	10.37	200	584693	39762	63874077
Dehydration	42.98	10.37	2390	582503	214373	63699466
Haemophagocytic lymphohistiocytosis	42.95	10.37	58	584835	17551	63896288
Blood glucose increased	42.82	10.37	1179	583714	96894	63816945
Personality disorder	42.60	10.37	116	584777	4595	63909244
Cardiac failure	42.18	10.37	1532	583361	130841	63782998
Mydriasis	42.04	10.37	46	584847	15266	63898573
Device issue	41.97	10.37	89	584804	22559	63891280
Dysarthria	41.69	10.37	764	584129	58642	63855197
Anti-neutrophil cytoplasmic antibody positive vasculitis	41.46	10.37	86	584807	2850	63910989
Blood potassium decreased	41.09	10.37	553	584340	39846	63873993
Acute hepatic failure	40.95	10.37	112	584781	26000	63887839
Eating disorder	40.93	10.37	277	584616	16528	63897311
Graft versus host disease	40.76	10.37	39	584854	13774	63900065
Hypocalcaemia	40.62	10.37	567	584326	41186	63872653
Haemodynamic instability	40.10	10.37	252	584641	14660	63899179
Disability	40.02	10.37	31	584862	12141	63901698
Agitation	40	10.37	562	584331	87805	63826034
Chronic graft versus host disease	39.75	10.37	5	584888	6271	63907568
Erectile dysfunction	39.49	10.37	222	584671	12405	63901434
Caesarean section	39.29	10.37	27	584866	11247	63902592
Neurotoxicity	39.02	10.37	123	584770	27281	63886558
Haemodialysis	38.95	10.37	277	584616	16800	63897039
5-hydroxyindolacetic acid in urine increased	38.79	10.37	25	584868	209	63913630
Progressive multifocal leukoencephalopathy	38.73	10.37	66	584827	18166	63895673
BRASH syndrome	38.58	10.37	30	584863	347	63913492
Atrioventricular block second degree	38.05	10.37	137	584756	6317	63907522
Urticaria	37.88	10.37	1031	583862	146286	63767553
Therapy partial responder	37.82	10.37	23	584870	10225	63903614
Periodontitis	37.20	10.37	102	584791	4057	63909782
Hypoinsulinaemia	37.12	10.37	10	584883	0	63913839
Multiple-drug resistance	37.05	10.37	7	584886	6495	63907344
Product substitution issue	36.91	10.37	283	584610	17578	63896261
Inappropriate antidiuretic hormone secretion	36.91	10.37	336	584557	21953	63891886
Carotid arteriosclerosis	36.81	10.37	67	584826	2012	63911827
Unintentional medical device removal	36.81	10.37	8	584885	6726	63907113
Faeces discoloured	36.76	10.37	376	584517	25353	63888486
Diabetic nephropathy	36.62	10.37	77	584816	2577	63911262
Prescription drug used without a prescription	36.53	10.37	76	584817	2524	63911315
Thalamus haemorrhage	36.37	10.37	58	584835	1561	63912278
Chest pain	36.27	10.37	2545	582348	233435	63680404
Osteoporosis	36.19	10.37	228	584665	41852	63871987
Glomerulonephritis rapidly progressive	36.11	10.37	52	584841	1276	63912563
Irritability	35.94	10.37	191	584702	36555	63877284
Device adhesion issue	35.77	10.37	3	584890	5183	63908656
Hyperuricaemia	35.13	10.37	184	584709	10007	63903832
Seizure	35.05	10.37	1200	583693	165692	63748147
Hepatocellular carcinoma	34.90	10.37	160	584733	8243	63905596
Hemiparesis	34.88	10.37	419	584474	29408	63884431
Arteriosclerosis	34.75	10.37	255	584638	15622	63898217
Anaemia	34.70	10.37	3932	580961	374748	63539091
Metastatic renal cell carcinoma	34.21	10.37	67	584826	2129	63911710
Substance abuse	34.09	10.37	21	584872	9271	63904568
Status epilepticus	33.91	10.37	93	584800	21570	63892269
Acute myeloid leukaemia	33.90	10.37	131	584762	27332	63886507
Ovarian cyst	33.83	10.37	30	584863	10988	63902851
Hyperaldosteronism	33.72	10.37	28	584865	358	63913481
Glomerular filtration rate decreased	33.41	10.37	297	584596	19275	63894564
Staphylococcal infection	33.37	10.37	296	584597	50382	63863457
Cardiomegaly	33.30	10.37	345	584548	23339	63890500
Oedema	33.30	10.37	1080	583813	90855	63822984
Drug withdrawal syndrome	33.26	10.37	158	584735	31133	63882706
Diastolic dysfunction	33.23	10.37	164	584729	8711	63905128
Linear IgA disease	33.19	10.37	76	584817	2698	63911141
Drug tolerance decreased	33.19	10.37	11	584882	6987	63906852
Febrile bone marrow aplasia	32.95	10.37	32	584861	11223	63902616
Urine output decreased	32.80	10.37	259	584634	16233	63897606
Tongue oedema	32.67	10.37	124	584769	5866	63907973
Pancytopenia	32.56	10.37	1020	583873	142289	63771550
Allergic reaction to excipient	32.39	10.37	23	584870	229	63913610
Malaise	32.29	10.37	4084	580809	392163	63521676
Lymphocyte count decreased	32.25	10.37	226	584667	40473	63873366
Nephrosclerosis	32.20	10.37	54	584839	1517	63912322
Psychotic disorder	32.03	10.37	183	584710	34395	63879444
Cerebral haemorrhage	31.74	10.37	645	584248	50445	63863394
Uterine perforation	31.64	10.37	7	584886	5813	63908026
Presyncope	31.55	10.37	470	584423	34619	63879220
Dyspnoea exertional	31.51	10.37	884	584009	72846	63840993
Ischaemic stroke	31.43	10.37	402	584491	28633	63885206
Primary hyperaldosteronism	31.36	10.37	18	584875	119	63913720
Peripheral arterial occlusive disease	31.24	10.37	136	584757	6851	63906988
Palmar-plantar erythrodysaesthesia syndrome	31.19	10.37	399	584494	28420	63885419
Vasodilatation	31.06	10.37	78	584815	2940	63910899
Dystonia	31.04	10.37	79	584814	18786	63895053
Drug ineffective for unapproved indication	30.91	10.37	161	584732	30972	63882867
Generalised oedema	30.88	10.37	307	584586	20546	63893293
Gastric ulcer haemorrhage	30.86	10.37	151	584742	7992	63905847
Lymphadenopathy	30.60	10.37	273	584620	46413	63867426
Pollakiuria	30.60	10.37	428	584465	31102	63882737
Bronchopulmonary aspergillosis	30.58	10.37	81	584812	19004	63894835
Bundle branch block right	30.45	10.37	178	584715	10091	63903748
Altered state of consciousness	30.02	10.37	497	584396	37405	63876434
Venoocclusive liver disease	29.88	10.37	28	584865	9987	63903852
Injection site haemorrhage	29.84	10.37	116	584777	24162	63889677
Swelling face	29.82	10.37	725	584168	58441	63855398
Premature labour	29.70	10.37	16	584877	7604	63906235
Mitral valve incompetence	29.54	10.37	358	584535	25180	63888659
Acute coronary syndrome	29.43	10.37	286	584607	19024	63894815
Gastrointestinal tract mucosal pigmentation	29.26	10.37	39	584854	888	63912951
Fatigue	29.22	10.37	6173	578720	742557	63171282
Injection site urticaria	29.17	10.37	35	584858	11146	63902693
Haematemesis	29.08	10.37	593	584300	46406	63867433
Ischaemia	29.06	10.37	137	584756	7141	63906698
Diabetic neuropathy	28.96	10.37	114	584779	5487	63908352
Gout	28.74	10.37	309	584584	21104	63892735
Panniculitis	28.70	10.37	23	584870	8856	63904983
Tubulointerstitial nephritis	28.57	10.37	416	584477	30493	63883346
Knee arthroplasty	28.30	10.37	137	584756	26862	63886977
Gingivitis	28.30	10.37	141	584752	7518	63906321
Blood aldosterone increased	28.26	10.37	20	584873	198	63913641
Disease recurrence	28.00	10.37	169	584724	31341	63882498
Cytomegalovirus infection reactivation	27.38	10.37	9	584884	5747	63908092
Heavy menstrual bleeding	27.27	10.37	42	584851	12035	63901804
Bladder irritation	27.22	10.37	20	584873	211	63913628
Adenovirus infection	27.17	10.37	16	584877	7239	63906600
Myelodysplastic syndrome	27.17	10.37	143	584750	27436	63886403
Herpes zoster	27.15	10.37	530	584363	78657	63835182
Blood mercury abnormal	26.86	10.37	19	584874	188	63913651
Metastases to bone	26.84	10.37	95	584798	20340	63893499
Hypervolaemia	26.73	10.37	492	584401	37793	63876046
Aphasia	26.61	10.37	520	584373	40386	63873453
Blood parathyroid hormone decreased	26.54	10.37	17	584876	7349	63906490
Blood uric acid increased	26.52	10.37	145	584748	8018	63905821
Gastric cancer	26.50	10.37	123	584770	6370	63907469
Myocardial ischaemia	26.48	10.37	325	584568	22926	63890913
Blood lactic acid increased	26.27	10.37	173	584720	10228	63903611
Carotid sinus syndrome	26.26	10.37	12	584881	45	63913794
Accelerated hypertension	26.09	10.37	30	584863	584	63913255
Device use error	26.09	10.37	13	584880	6458	63907381
Graft versus host disease in skin	26.08	10.37	8	584885	5339	63908500
Thirst	25.95	10.37	218	584675	13919	63899920
Venoocclusive disease	25.67	10.37	3	584890	3982	63909857
Upper respiratory tract infection	25.61	10.37	485	584408	72300	63841539
Skin toxicity	25.53	10.37	14	584879	6588	63907251
Eczema	25.52	10.37	395	584498	29325	63884514
Prostatic specific antigen increased	25.43	10.37	151	584742	8609	63905230
Premature delivery	25.38	10.37	85	584808	18504	63895335
Drug hypersensitivity	25.35	10.37	1835	583058	235980	63677859
Sepsis	25.26	10.37	1773	583120	228568	63685271
Mucormycosis	25.03	10.37	18	584875	7323	63906516
Sinus arrest	24.92	10.37	73	584820	3017	63910822
Accidental exposure to product	24.70	10.37	139	584754	26225	63887614
Nodule	24.54	10.37	82	584811	17865	63895974
Hypoperfusion	24.53	10.37	61	584832	2285	63911554
Red blood cell sedimentation rate increased	24.47	10.37	174	584719	31061	63882778
Putamen haemorrhage	24.35	10.37	25	584868	426	63913413
Enthesopathy	24.27	10.37	31	584862	9607	63904232
Sickle cell anaemia with crisis	24.22	10.37	9	584884	5323	63908516
Brain stem infarction	24.12	10.37	52	584841	1771	63912068
Hypertensive encephalopathy	24.12	10.37	35	584858	865	63912974
Pulmonary renal syndrome	24.12	10.37	28	584865	551	63913288
Abortion induced	24.05	10.37	14	584879	6374	63907465
Dialysis	24.04	10.37	247	584646	16673	63897166
Anaphylactic reaction	24.02	10.37	458	584435	68206	63845633
Fibromuscular dysplasia	23.96	10.37	18	584875	197	63913642
Orbital myositis	23.95	10.37	16	584877	143	63913696
Serotonin syndrome	23.90	10.37	234	584659	39048	63874791
Foetal death	23.78	10.37	12	584881	5918	63907921
Lung diffusion test abnormal	23.77	10.37	16	584877	145	63913694
Candida infection	23.67	10.37	177	584716	31242	63882597
Device dislocation	23.66	10.37	105	584788	21073	63892766
Fear of injection	23.65	10.37	12	584881	5900	63907939
Adverse drug reaction	23.57	10.37	281	584612	45183	63868656
Respiratory depression	23.40	10.37	121	584772	23322	63890517
Supraventricular extrasystoles	23.37	10.37	111	584782	5804	63908035
Granuloma skin	23.31	10.37	13	584880	6061	63907778
Plasmapheresis	23.31	10.37	28	584865	572	63913267
Ageusia	23.26	10.37	209	584684	13604	63900235
Arrhythmia	23.25	10.37	637	584256	52307	63861532
Drug use disorder	23.17	10.37	13	584880	6041	63907798
Device difficult to use	23.17	10.37	33	584860	9765	63904074
Lymphocele	23.10	10.37	48	584845	1593	63912246
Medication error	23.03	10.37	605	584288	49361	63864478
Yellow skin	22.91	10.37	71	584822	3028	63910811
Hepatojugular reflux	22.82	10.37	26	584867	501	63913338
Myopathy	22.75	10.37	253	584640	17427	63896412
Flushing	22.73	10.37	541	584352	78107	63835732
Blood cholinesterase decreased	22.68	10.37	18	584875	215	63913624
Ischaemic cardiomyopathy	22.58	10.37	122	584771	6716	63907123
Epstein-Barr virus infection	22.37	10.37	50	584843	12438	63901401
Alcohol abuse	22.36	10.37	8	584885	4844	63908995
Heart rate decreased	22.36	10.37	656	584237	54411	63859428
Duodenal ulcer haemorrhage	22.36	10.37	115	584778	6210	63907629
Injection site rash	22.17	10.37	71	584822	15671	63898168
Fungal infection	22.13	10.37	201	584692	34050	63879789
Cognitive disorder	22.03	10.37	655	584238	54432	63859407
Ventricular hypertrophy	22.02	10.37	117	584776	6399	63907440
Hypovolaemic shock	21.96	10.37	164	584729	10102	63903737
Pericardial effusion	21.94	10.37	488	584405	38766	63875073
Affect lability	21.78	10.37	148	584745	8842	63904997
Disease progression	21.75	10.37	1056	583837	140624	63773215
Joint effusion	21.72	10.37	57	584836	13416	63900423
Multiple sclerosis	21.71	10.37	93	584800	18848	63894991
Large intestine polyp	21.45	10.37	170	584723	10667	63903172
Hyperplasia	21.38	10.37	37	584856	1067	63912772
Lymphocyte stimulation test positive	21.33	10.37	37	584856	1069	63912770
Osteopenia	21.25	10.37	71	584822	15469	63898370
Tendonitis	21.21	10.37	103	584790	20179	63893660
Red blood cell sedimentation rate	21.16	10.37	4	584889	3710	63910129
Suicidal ideation	21.13	10.37	451	584442	66091	63847748
Coma	21.02	10.37	619	584274	86996	63826843
Scleral discolouration	20.96	10.37	25	584868	507	63913332
Human herpesvirus 6 infection	20.90	10.37	8	584885	4646	63909193
Blood glucose decreased	20.89	10.37	310	584583	22813	63891026
Labile hypertension	20.88	10.37	25	584868	509	63913330
Joint destruction	20.54	10.37	4	584889	3632	63910207
Liver carcinoma ruptured	20.51	10.37	15	584878	157	63913682
Varicella zoster virus infection	20.49	10.37	5	584888	3883	63909956
Blister	20.45	10.37	568	584325	80399	63833440
Low density lipoprotein decreased	20.42	10.37	36	584857	1054	63912785
Cardiovascular disorder	20.31	10.37	227	584666	15654	63898185
Congenital hiatus hernia	20.31	10.37	22	584871	400	63913439
Bundle branch block left	20.19	10.37	158	584735	9876	63903963
Urine albumin/creatinine ratio increased	20.09	10.37	20	584873	328	63913511
Gestational diabetes	20.00	10.37	13	584880	5577	63908262
Blood potassium increased	19.96	10.37	339	584554	25641	63888198
Hypergastrinaemia	19.90	10.37	15	584878	165	63913674
Diabetes mellitus	19.88	10.37	764	584129	65710	63848129
Diverticulum intestinal haemorrhagic	19.79	10.37	70	584823	3199	63910640
Forced vital capacity decreased	19.78	10.37	43	584850	1473	63912366
Ear pain	19.71	10.37	140	584753	24996	63888843
Lipodystrophy acquired	19.68	10.37	6	584887	4021	63909818
Viral infection	19.66	10.37	221	584672	35919	63877920
Nipple inflammation	19.66	10.37	10	584883	50	63913789
Ocular icterus	19.66	10.37	95	584798	5003	63908836
Rales	19.63	10.37	218	584675	15011	63898828
Cytomegalovirus chorioretinitis	19.61	10.37	10	584883	4902	63908937
Hepatic neoplasm	19.59	10.37	67	584826	3010	63910829
Product dose omission issue	19.58	10.37	1510	583383	193237	63720602
Polypectomy	19.53	10.37	33	584860	933	63912906
Inflammation	19.47	10.37	447	584446	64853	63848986
Sinus node dysfunction	19.38	10.37	117	584776	6711	63907128
Mycobacterium marinum infection	19.37	10.37	21	584872	382	63913457
Temperature regulation disorder	19.31	10.37	7	584886	4204	63909635
Lichen nitidus	19.26	10.37	11	584882	72	63913767
Diabetic retinopathy	19.13	10.37	63	584830	2776	63911063
Gravitational oedema	19.12	10.37	45	584848	1627	63912212
Polymyositis	19.03	10.37	61	584832	2649	63911190
Headache	19.02	10.37	4382	580511	525085	63388754
Renal transplant	18.99	10.37	54	584839	2194	63911645
Bundle branch block	18.97	10.37	41	584852	1399	63912440
Peripheral artery stenosis	18.97	10.37	37	584856	1172	63912667
Gastrointestinal haemorrhage	18.94	10.37	1419	583474	130893	63782946
Left ventricular enlargement	18.92	10.37	27	584866	657	63913182
Cytomegalovirus viraemia	18.87	10.37	44	584849	10784	63903055
Uveitis	18.83	10.37	56	584837	12652	63901187
Skin tightness	18.81	10.37	92	584801	4869	63908970
Epiglottic oedema	18.77	10.37	17	584876	246	63913593
Kidney transplant rejection	18.71	10.37	149	584744	9362	63904477
Subdural haematoma	18.71	10.37	358	584535	27696	63886143
Unintended pregnancy	18.68	10.37	3	584890	3131	63910708
Prerenal failure	18.66	10.37	68	584825	3154	63910685
Tricuspid valve incompetence	18.65	10.37	236	584657	16767	63897072
Hypersensitivity vasculitis	18.65	10.37	115	584778	6646	63907193
Prostate cancer recurrent	18.57	10.37	28	584865	717	63913122
Mucosal membrane hyperplasia	18.52	10.37	9	584884	40	63913799
Coeliac disease	18.50	10.37	24	584869	7388	63906451
Injection site discolouration	18.50	10.37	21	584872	6854	63906985
Zoonotic bacterial infection	18.48	10.37	10	584883	58	63913781
Dry eye	18.45	10.37	171	584722	28848	63884991
Blood loss anaemia	18.43	10.37	200	584693	13692	63900147
Bladder sphincter atony	18.36	10.37	12	584881	103	63913736
CD30 expression	18.35	10.37	9	584884	41	63913798
Coordination abnormal	18.29	10.37	212	584681	14752	63899087
Ventricular hyperkinesia	18.23	10.37	17	584876	256	63913583
Enterochromaffin cell hyperplasia	18.20	10.37	11	584882	81	63913758
Chondroma	18.17	10.37	6	584887	6	63913833
Vaginal haemorrhage	18.12	10.37	102	584791	19242	63894597
Pulse abnormal	17.93	10.37	59	584834	2598	63911241
Breath sounds abnormal	17.86	10.37	173	584720	11496	63902343
Fibrillary glomerulonephritis	17.85	10.37	9	584884	44	63913795
Generalised tonic-clonic seizure	17.85	10.37	254	584639	39603	63874236
Portal hypertension	17.84	10.37	18	584875	6201	63907638
Dermatomyositis	17.78	10.37	61	584832	2745	63911094
Dyslalia	17.77	10.37	32	584861	953	63912886
C-reactive protein increased	17.75	10.37	692	584201	94217	63819622
Sensory loss	17.71	10.37	155	584738	10014	63903825
Dyskinesia	17.64	10.37	251	584642	39137	63874702
Cholecystitis chronic	17.62	10.37	36	584857	9251	63904588
Drug abuser	17.61	10.37	16	584877	5792	63908047
Neovascularisation	17.60	10.37	34	584859	1069	63912770
Graft versus host disease in gastrointestinal tract	17.57	10.37	15	584878	5597	63908242
Carcinoid tumour	17.56	10.37	21	584872	427	63913412
Premature rupture of membranes	17.55	10.37	6	584887	3738	63910101
Cardiac disorder	17.52	10.37	645	584248	55171	63858668
Atrioventricular dissociation	17.52	10.37	18	584875	307	63913532
Atheroembolism	17.48	10.37	16	584877	235	63913604
Nephrogenic systemic fibrosis	17.39	10.37	102	584791	5790	63908049
Electrocardiogram Q wave abnormal	17.37	10.37	20	584873	390	63913449
Chromaturia	17.36	10.37	295	584598	22316	63891523
Cerebellar haemorrhage	17.30	10.37	58	584835	2579	63911260
Chronic obstructive pulmonary disease	17.27	10.37	799	584094	70249	63843590
Embolic stroke	17.18	10.37	112	584781	6599	63907240
Arterial occlusive disease	17.17	10.37	116	584777	6917	63906922
Lethargy	17.13	10.37	814	584079	71780	63842059
Clear cell renal cell carcinoma	17.12	10.37	51	584842	2128	63911711
Traumatic haemorrhage	17.11	10.37	34	584859	1092	63912747
Ulcer	17.09	10.37	130	584763	22860	63890979
Dilatation ventricular	17.05	10.37	75	584818	3795	63910044
Drug tolerance	17.02	10.37	18	584875	6067	63907772
Pulmonary hypoplasia	16.94	10.37	9	584884	50	63913789
Gastrointestinal toxicity	16.94	10.37	14	584879	5308	63908531
Pulmonary valve disease	16.84	10.37	16	584877	247	63913592
Breast cancer stage III	16.83	10.37	3	584890	2902	63910937
Urinary retention	16.79	10.37	574	584319	48627	63865212
Retinopathy hypertensive	16.75	10.37	21	584872	449	63913390
Gingival pain	16.75	10.37	107	584786	6260	63907579
Fine motor skill dysfunction	16.72	10.37	11	584882	4688	63909151
Schizophrenia	16.70	10.37	49	584844	11119	63902720
Left atrial enlargement	16.70	10.37	32	584861	1000	63912839
Cardiac dysfunction	16.70	10.37	64	584829	3042	63910797
Bradyarrhythmia	16.69	10.37	73	584820	3685	63910154
Herpes simplex	16.66	10.37	45	584848	10491	63903348
Intestinal ischaemia	16.60	10.37	169	584724	11380	63902459
Paranoia	16.55	10.37	84	584809	16268	63897571
Dislocation of vertebra	16.50	10.37	4	584889	3120	63910719
Sensitivity to weather change	16.49	10.37	22	584871	6692	63907147
Hypoglossal nerve paralysis	16.47	10.37	7	584886	21	63913818
Normal newborn	16.41	10.37	16	584877	5601	63908238
Harlequin syndrome	16.39	10.37	9	584884	54	63913785
End stage renal disease	16.38	10.37	156	584737	10319	63903520
Type I hypersensitivity	16.29	10.37	6	584887	3568	63910271
Sinoatrial block	16.29	10.37	34	584859	1132	63912707
Tuberculosis	16.21	10.37	62	584831	12976	63900863
Aortic aneurysm	16.21	10.37	121	584772	7453	63906386
Obsessive-compulsive disorder	16.19	10.37	12	584881	4806	63909033
Gangrene	16.14	10.37	118	584775	7220	63906619
Pleural effusion	16.10	10.37	1345	583548	125214	63788625
Finger deformity	16.07	10.37	14	584879	5172	63908667
Product administered to patient of inappropriate age	16.06	10.37	11	584882	4590	63909249
Suspected suicide attempt	16.04	10.37	16	584877	263	63913576
Device related infection	15.99	10.37	189	584704	30437	63883402
Drug screen positive	15.96	10.37	17	584876	5712	63908127
Hyperparathyroidism secondary	15.96	10.37	52	584841	2278	63911561
Abnormal behaviour	15.87	10.37	212	584681	33410	63880429
Protein urine present	15.85	10.37	137	584756	8819	63905020
Pseudomonas infection	15.84	10.37	96	584797	17787	63896052
Dyspnoea at rest	15.82	10.37	105	584788	6224	63907615
Gallbladder adenocarcinoma	15.79	10.37	11	584882	106	63913733
Grip strength decreased	15.74	10.37	54	584839	11670	63902169
Joint stiffness	15.73	10.37	188	584705	30216	63883623
Femoral neck fracture	15.73	10.37	134	584759	8590	63905249
Stenosis	15.73	10.37	44	584849	1771	63912068
Device leakage	15.72	10.37	32	584861	8234	63905605
Neoplasm progression	15.66	10.37	269	584624	40695	63873144
Tricuspid valve calcification	15.66	10.37	5	584888	4	63913835
Azotaemia	15.57	10.37	119	584774	7383	63906456
Rectal ulcer haemorrhage	15.56	10.37	15	584878	236	63913603
Nasal crusting	15.55	10.37	22	584871	531	63913308
Deafness neurosensory	15.54	10.37	21	584872	6353	63907486
Alanine aminotransferase abnormal	15.51	10.37	24	584869	6864	63906975
Band neutrophil percentage decreased	15.47	10.37	6	584887	13	63913826
Dermatitis infected	15.44	10.37	14	584879	203	63913636
Incorrect route of product administration	15.37	10.37	136	584757	23162	63890677
Galactorrhoea	15.37	10.37	5	584888	3214	63910625
Intestinal villi atrophy	15.28	10.37	18	584875	360	63913479
Cystic fibrosis	15.26	10.37	6	584887	3428	63910411
Duodenal ulcer	15.26	10.37	199	584694	14236	63899603
Blood pressure abnormal	15.26	10.37	199	584694	14236	63899603
Mitochondrial toxicity	15.23	10.37	3	584890	2703	63911136
Renal injury	15.20	10.37	210	584683	15219	63898620
Pericardial haemorrhage	15.18	10.37	76	584817	4060	63909779
Neuroleptic malignant syndrome	15.16	10.37	149	584744	24847	63888992
Purpura	15.11	10.37	230	584663	17016	63896823
Transplant rejection	15.11	10.37	94	584799	17307	63896532
Diffuse large B-cell lymphoma	15.11	10.37	46	584847	10315	63903524
Micturition urgency	15.09	10.37	152	584741	10207	63903632
Nephrogenic anaemia	15.08	10.37	65	584828	3260	63910579
Adenoma benign	15.07	10.37	31	584862	1021	63912818
Constipation	15.01	10.37	2334	582559	227003	63686836
Body tinea	15.00	10.37	35	584858	1258	63912581
Metabolic alkalosis	15.00	10.37	73	584820	3855	63909984
Glucose tolerance impaired	14.98	10.37	105	584788	6338	63907501
Intestinal angioedema	14.97	10.37	27	584866	805	63913034
Complication of device insertion	14.97	10.37	14	584879	4998	63908841
Peripheral artery occlusion	14.90	10.37	48	584845	2090	63911749
Hypothermia	14.86	10.37	258	584635	19598	63894241
Ventricular compliance decreased	14.85	10.37	4	584889	0	63913839
Sinonasal obstruction	14.82	10.37	13	584880	180	63913659
Idiopathic pulmonary fibrosis	14.79	10.37	71	584822	3729	63910110
Mean arterial pressure decreased	14.74	10.37	17	584876	332	63913507
Hepatosplenomegaly	14.73	10.37	16	584877	5327	63908512
Hepatic failure	14.66	10.37	386	584507	55008	63858831
Benign neoplasm of adrenal gland	14.60	10.37	7	584886	30	63913809
Death	14.60	10.37	4026	580867	478679	63435160
Glucose urine present	14.57	10.37	40	584853	1592	63912247
Hyperthermia	14.56	10.37	82	584811	15468	63898371
Synovial cyst	14.52	10.37	30	584863	7677	63906162
Amenorrhoea	14.52	10.37	23	584870	6516	63907323
Osteonecrosis	14.43	10.37	175	584718	28054	63885785
Gastric pH increased	14.43	10.37	8	584885	49	63913790
Upper gastrointestinal haemorrhage	14.41	10.37	420	584473	34800	63879039
Acute graft versus host disease in skin	14.39	10.37	25	584868	6830	63907009
Product label on wrong product	14.36	10.37	6	584887	17	63913822
Immune-mediated myositis	14.25	10.37	55	584838	2623	63911216
Sex hormone binding globulin increased	14.25	10.37	5	584888	7	63913832
Device deployment issue	14.20	10.37	4	584889	2822	63911017
Neuropathy peripheral	14.15	10.37	897	583996	116628	63797211
Klebsiella infection	14.15	10.37	67	584826	13214	63900625
Device breakage	14.15	10.37	37	584856	8718	63905121
Sexual dysfunction	14.14	10.37	23	584870	6448	63907391
Hypertonic bladder	14.13	10.37	65	584828	3353	63910486
Gingival disorder	14.13	10.37	64	584829	3280	63910559
Dysgeusia	14.13	10.37	541	584352	46506	63867333
Pericardial disease	14.09	10.37	20	584873	484	63913355
Immunosuppression	14.09	10.37	50	584843	10696	63903143
Muscle necrosis	14.08	10.37	33	584860	1190	63912649
Pelvi-ureteric obstruction	14.05	10.37	8	584885	52	63913787
Glomerulonephritis acute	14.04	10.37	12	584881	160	63913679
Dermatosis	14.03	10.37	20	584873	486	63913353
Blood parathyroid hormone increased	14.01	10.37	61	584832	3073	63910766
Base excess decreased	13.98	10.37	17	584876	352	63913487
Foetal exposure during pregnancy	13.97	10.37	12	584881	4464	63909375
Vasculitis	13.86	10.37	236	584657	17859	63895980
Hyperprolactinaemia	13.82	10.37	10	584883	4055	63909784
Toxic nodular goitre	13.76	10.37	7	584886	35	63913804
Pulmonary embolism	13.75	10.37	1141	583752	145215	63768624
Wrong patient received product	13.72	10.37	69	584824	3693	63910146
Product storage error	13.72	10.37	68	584825	13250	63900589
Encephalitis toxic	13.70	10.37	15	584878	276	63913563
Drug level below therapeutic	13.69	10.37	29	584864	7355	63906484
Zinc deficiency	13.69	10.37	8	584885	55	63913784
Faecal calprotectin increased	13.67	10.37	8	584885	3632	63910207
Genital haemorrhage	13.66	10.37	18	584875	5504	63908335
Colon cancer	13.63	10.37	176	584717	12563	63901276
Guillain-Barre syndrome	13.62	10.37	117	584776	7518	63906321
Osteoarthritis	13.61	10.37	454	584439	62882	63850957
Cellulitis of male external genital organ	13.60	10.37	7	584886	36	63913803
Autoimmune enteropathy	13.60	10.37	7	584886	36	63913803
Enterococcal infection	13.60	10.37	72	584821	13794	63900045
Arthritis	13.59	10.37	621	584272	83193	63830646
Essential hypertension	13.49	10.37	87	584806	5107	63908732
Nipple disorder	13.46	10.37	12	584881	170	63913669
Femoral artery dissection	13.45	10.37	7	584886	37	63913802
Tongue disorder	13.43	10.37	60	584833	12020	63901819
Neuroendocrine tumour	13.36	10.37	31	584862	1110	63912729
Angiopathy	13.36	10.37	100	584793	6165	63907674
Hypertensive urgency	13.35	10.37	16	584877	326	63913513
Haemoglobin decreased	13.32	10.37	1990	582903	193073	63720766
Blood sodium decreased	13.31	10.37	356	584537	29126	63884713
Eyelid oedema	13.28	10.37	170	584723	12109	63901730
Aortic stenosis	13.23	10.37	101	584792	6264	63907575
Cross sensitivity reaction	13.22	10.37	7	584886	3360	63910479
Listless	13.19	10.37	62	584831	3228	63910611
Skin necrosis	13.18	10.37	76	584817	14253	63899586
Renovascular hypertension	13.16	10.37	7	584886	39	63913800
Therapy non-responder	13.09	10.37	477	584416	65422	63848417
Cell marker increased	13.07	10.37	22	584871	620	63913219
Myositis	13.06	10.37	215	584678	16162	63897677
Hyperplastic cholecystopathy	13.05	10.37	10	584883	113	63913726
Lung hernia	13.01	10.37	8	584885	61	63913778
Hypertensive cardiomyopathy	13.01	10.37	15	584878	293	63913546
Microalbuminuria	13.00	10.37	26	584867	839	63913000
Motor dysfunction	12.96	10.37	159	584734	11214	63902625
Breast cancer	12.96	10.37	186	584707	28962	63884877
Cardiac myxoma	12.91	10.37	10	584883	115	63913724
Coronary artery surgery	12.91	10.37	12	584881	180	63913659
Continuous haemodiafiltration	12.89	10.37	43	584850	1907	63911932
Acute pulmonary oedema	12.88	10.37	175	584718	12634	63901205
Accidental death	12.88	10.37	9	584884	3716	63910123
White blood cell count decreased	12.86	10.37	1244	583649	156593	63757246
Colitis ulcerative	12.85	10.37	140	584753	22888	63890951
Carcinoid tumour of the stomach	12.80	10.37	12	584881	182	63913657
Chills	12.76	10.37	1071	583822	136193	63777646
Multiple organ dysfunction syndrome	12.74	10.37	771	584122	100642	63813197
Coronary artery stenosis	12.71	10.37	157	584736	11091	63902748
Drug level increased	12.71	10.37	403	584490	33793	63880046
Disturbance in social behaviour	12.65	10.37	10	584883	3877	63909962
Blood cholinesterase increased	12.65	10.37	6	584887	25	63913814
Taste disorder	12.60	10.37	136	584757	9297	63904542
Injury	12.59	10.37	399	584494	55593	63858246
Multiple drug therapy	12.58	10.37	47	584846	2207	63911632
Pericarditis uraemic	12.55	10.37	5	584888	12	63913827
Acidosis	12.53	10.37	229	584664	17566	63896273
Hallucination, gustatory	12.50	10.37	8	584885	66	63913773
Acute motor-sensory axonal neuropathy	12.49	10.37	17	584876	395	63913444
Toxic skin eruption	12.49	10.37	245	584648	19039	63894800
Stent placement	12.49	10.37	90	584803	5481	63908358
Pleuritic pain	12.49	10.37	35	584858	8061	63905778
Abnormal loss of weight	12.48	10.37	112	584781	7288	63906551
Leukaemoid reaction	12.47	10.37	15	584878	307	63913532
Leukaemia recurrent	12.44	10.37	4	584889	2590	63911249
Rhinovirus infection	12.43	10.37	23	584870	6133	63907706
Inappropriate schedule of product administration	12.42	10.37	697	584196	91589	63822250
Urine flow decreased	12.32	10.37	28	584865	989	63912850
Tachycardia	12.31	10.37	1178	583715	148401	63765438
Hypertensive nephropathy	12.31	10.37	25	584868	816	63913023
Primary hypoparathyroidism	12.29	10.37	6	584887	27	63913812
Fulminant type 1 diabetes mellitus	12.28	10.37	29	584864	1051	63912788
Venous oxygen saturation decreased	12.27	10.37	5	584888	13	63913826
Gynaecomastia	12.25	10.37	95	584798	5921	63907918
Macrophages increased	12.24	10.37	12	584881	193	63913646
Renal artery occlusion	12.23	10.37	10	584883	125	63913714
Coronary arterial stent insertion	12.22	10.37	91	584802	5601	63908238
Blood urea abnormal	12.20	10.37	31	584862	1177	63912662
Nephropathy	12.19	10.37	123	584770	8263	63905576
Beta 2 microglobulin urine increased	12.16	10.37	10	584883	126	63913713
Adverse event	12.15	10.37	269	584624	39220	63874619
Periarticular disorder	12.12	10.37	6	584887	28	63913811
Cerebral ischaemia	12.11	10.37	141	584752	9821	63904018
Pleural mass	12.11	10.37	8	584885	70	63913769
Venous aneurysm	12.11	10.37	4	584889	4	63913835
Vagus nerve disorder	12.11	10.37	7	584886	47	63913792
Exposure via ingestion	12.06	10.37	81	584812	4821	63909018
Hypertensive angiopathy	12.02	10.37	9	584884	98	63913741
Transaminases increased	12.00	10.37	310	584583	44284	63869555
Depression	11.96	10.37	1467	583426	181824	63732015
Optic nerve injury	11.95	10.37	20	584873	561	63913278
Norepinephrine increased	11.93	10.37	8	584885	72	63913767
Phaeochromocytoma malignant	11.93	10.37	8	584885	72	63913767
Gingival atrophy	11.93	10.37	8	584885	72	63913767
Thrombotic cerebral infarction	11.85	10.37	18	584875	464	63913375
Peripheral coldness	11.84	10.37	181	584712	13403	63900436
Bursitis	11.84	10.37	131	584762	21354	63892485
Tardive dyskinesia	11.83	10.37	43	584850	9135	63904704
Carbohydrate metabolism disorder	11.79	10.37	6	584887	30	63913809
Fistula	11.77	10.37	47	584846	9714	63904125
Psychogenic visual disorder	11.77	10.37	5	584888	15	63913824
Cytomegalovirus colitis	11.70	10.37	11	584882	3917	63909922
Intraventricular haemorrhage	11.68	10.37	71	584822	4082	63909757
Physical examination abnormal	11.68	10.37	13	584880	244	63913595
Intentional product misuse	11.65	10.37	536	584357	71759	63842080
Cardiac valve sclerosis	11.65	10.37	9	584884	103	63913736
Bromhidrosis	11.65	10.37	4	584889	5	63913834
Lichenification	11.65	10.37	22	584871	680	63913159
Pelvic cyst	11.65	10.37	7	584886	51	63913788
Post-traumatic amnestic disorder	11.65	10.37	7	584886	51	63913788
Brain oedema	11.61	10.37	136	584757	21939	63891900
Device malfunction	11.60	10.37	103	584790	17530	63896309
Pharyngitis streptococcal	11.58	10.37	40	584853	8628	63905211
Aphthous ulcer	11.58	10.37	69	584824	12837	63901002
Psychomotor hyperactivity	11.57	10.37	80	584813	14371	63899468
Oral discharge	11.55	10.37	13	584880	247	63913592
Loose tooth	11.55	10.37	55	584838	2879	63910960
Surfactant protein increased	11.53	10.37	5	584888	16	63913823
Muscle spasms	11.51	10.37	1454	583439	139569	63774270
Henoch-Schonlein purpura	11.49	10.37	45	584848	2161	63911678
Pulmonary alveolar haemorrhage	11.47	10.37	137	584756	9601	63904238
Anorexia nervosa	11.47	10.37	11	584882	172	63913667
Jaundice	11.45	10.37	544	584349	47968	63865871
Oropharyngeal pain	11.45	10.37	674	584219	88193	63825646
Interstitial granulomatous dermatitis	11.44	10.37	12	584881	210	63913629
Intermenstrual bleeding	11.40	10.37	18	584875	5107	63908732
Flatulence	11.40	10.37	413	584480	35253	63878586
Lung diffusion test decreased	11.37	10.37	30	584863	1166	63912673
Benign gastrointestinal neoplasm	11.37	10.37	10	584883	139	63913700
Dysphonia	11.35	10.37	522	584371	45860	63867979
Myasthenia gravis	11.35	10.37	90	584803	5648	63908191
Neurosensory hypoacusis	11.35	10.37	12	584881	212	63913627
Poor venous access	11.35	10.37	66	584827	12351	63901488
Macroglossia	11.34	10.37	28	584865	1044	63912795
Thromboangiitis obliterans	11.34	10.37	6	584887	33	63913806
Tumour lysis syndrome	11.33	10.37	117	584776	19323	63894516
Muscular weakness	11.32	10.37	1320	583573	126018	63787821
Ureteric cancer	11.31	10.37	13	584880	253	63913586
Ventricular drainage	11.31	10.37	5	584888	17	63913822
Retinal ischaemia	11.25	10.37	22	584871	698	63913141
Renal artery thrombosis	11.25	10.37	17	584876	436	63913403
Peritoneal dialysis complication	11.24	10.37	45	584848	2183	63911656
Gingival hypoplasia	11.24	10.37	4	584889	6	63913833
Pleuroperitoneal communication	11.24	10.37	4	584889	6	63913833
Hepatitis E	11.22	10.37	4	584889	2427	63911412
Vaginal infection	11.21	10.37	17	584876	4903	63908936
Giant cell arteritis	11.21	10.37	46	584847	2257	63911582
Bone pain	11.18	10.37	337	584556	47235	63866604
Product solubility abnormal	11.18	10.37	24	584869	815	63913024
Metastases to central nervous system	11.14	10.37	77	584816	13835	63900004
Glucose tolerance increased	11.14	10.37	3	584890	0	63913839
Diabetic enteropathy	11.14	10.37	3	584890	0	63913839
Craniectomy	11.14	10.37	3	584890	0	63913839
Tear discolouration	11.14	10.37	3	584890	0	63913839
Crush syndrome	11.12	10.37	11	584882	179	63913660
Cogwheel rigidity	11.10	10.37	6	584887	2847	63910992
Hydronephrosis	11.10	10.37	185	584708	13940	63899899
Homicidal ideation	11.09	10.37	8	584885	3249	63910590
Streptococcal infection	11.05	10.37	33	584860	7446	63906393
Ventricular failure	11.01	10.37	18	584875	495	63913344
Tenderness	11.01	10.37	119	584774	19483	63894356
Brain abscess	11	10.37	13	584880	4168	63909671
Cold sweat	10.98	10.37	210	584683	16245	63897594
Electrocardiogram U wave present	10.97	10.37	9	584884	113	63913726
Infected dermal cyst	10.95	10.37	23	584870	769	63913070
Clostridium difficile infection	10.93	10.37	247	584646	35916	63877923
Omphalitis	10.92	10.37	6	584887	36	63913803
Appendicitis	10.92	10.37	75	584818	13494	63900345
Respiratory arrest	10.87	10.37	382	584511	52603	63861236
Inhibitory drug interaction	10.84	10.37	63	584830	3564	63910275
Pneumothorax traumatic	10.83	10.37	12	584881	224	63913615
Peripheral ischaemia	10.83	10.37	120	584773	8258	63905581
Faeces hard	10.82	10.37	43	584850	2079	63911760
Intestinal stenosis	10.80	10.37	8	584885	3206	63910633
Osteoporotic fracture	10.80	10.37	10	584883	3588	63910251
Skin candida	10.77	10.37	37	584856	1666	63912173
Helicobacter gastritis	10.75	10.37	44	584849	2156	63911683
IgA nephropathy	10.74	10.37	33	584860	1401	63912438
Underdose	10.74	10.37	167	584726	25662	63888177
Nystagmus	10.72	10.37	44	584849	9024	63904815
Herbal interaction	10.72	10.37	16	584877	406	63913433
Cardiac failure acute	10.71	10.37	208	584685	16136	63897703
Brain contusion	10.70	10.37	30	584863	1209	63912630
Kidney fibrosis	10.70	10.37	56	584837	3045	63910794
Flour sensitivity	10.69	10.37	5	584888	20	63913819
Retroperitoneal oedema	10.69	10.37	5	584888	20	63913819
Malignant neoplasm of renal pelvis	10.66	10.37	9	584884	118	63913721
Deformity	10.65	10.37	26	584867	6271	63907568
Metabolic disorder	10.64	10.37	35	584858	7662	63906177
Mycobacterium avium complex infection	10.64	10.37	12	584881	3928	63909911
Rib deformity	10.59	10.37	9	584884	119	63913720
Subarachnoid haemorrhage	10.55	10.37	230	584663	18208	63895631
Splenic rupture	10.55	10.37	44	584849	2175	63911664
Malignant hypertension	10.54	10.37	33	584860	1415	63912424
Attention deficit hyperactivity disorder	10.53	10.37	6	584887	2764	63911075
Generalised bullous fixed drug eruption	10.53	10.37	4	584889	8	63913831
Splenomegaly	10.51	10.37	108	584785	17853	63895986
Adrenal mass	10.51	10.37	26	584867	971	63912868
Incorrect dose administered by device	10.50	10.37	13	584880	4084	63909755
JC virus infection	10.46	10.37	9	584884	3346	63910493
Stent malfunction	10.44	10.37	7	584886	63	63913776
Menstruation irregular	10.42	10.37	15	584878	4420	63909419
Heat illness	10.42	10.37	15	584878	368	63913471
Basal ganglia stroke	10.41	10.37	9	584884	122	63913717
Hypogammaglobulinaemia	10.37	10.37	53	584840	10246	63903593

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C07FB07	CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents and calcium channel blockers
ATC	C07FB12	CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents and calcium channel blockers
ATC	C07FB13	CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS, OTHER COMBINATIONS Beta blocking agents and calcium channel blockers
ATC	C08CA01	CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS Dihydropyridine derivatives
ATC	C08CA51	CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS Dihydropyridine derivatives
ATC	C08GA02	CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS CALCIUM CHANNEL BLOCKERS AND DIURETICS Calcium channel blockers and diuretics
ATC	C09BB03	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and calcium channel blockers
ATC	C09BB04	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and calcium channel blockers
ATC	C09BB07	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors and calcium channel blockers
ATC	C09BX01	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors, other combinations
ATC	C09BX03	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors, other combinations
ATC	C09BX04	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ACE INHIBITORS, COMBINATIONS ACE inhibitors, other combinations
ATC	C09DB01	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC	C09DB02	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC	C09DB04	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC	C09DB05	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC	C09DB06	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC	C09DB07	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC	C09DB09	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC	C09DX01	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations
ATC	C09DX03	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations
ATC	C09DX06	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations
ATC	C09DX07	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS Angiotensin II receptor blockers (ARBs), other combinations
ATC	C09XA53	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM Renin-inhibitors
ATC	C09XA54	CARDIOVASCULAR SYSTEM AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM Renin-inhibitors
ATC	C10BX03	CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs
ATC	C10BX07	CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs
ATC	C10BX09	CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs
ATC	C10BX11	CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs
ATC	C10BX14	CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs
ATC	C10BX18	CARDIOVASCULAR SYSTEM LIPID MODIFYING AGENTS LIPID MODIFYING AGENTS, COMBINATIONS Lipid modifying agents in combination with other drugs
FDA CS	M0006414	Dihydropyridines
FDA MoA	N0000000069	Calcium Channel Antagonists
FDA EPC	N0000175421	Dihydropyridine Calcium Channel Blocker
FDA EPC	N0000175566	Calcium Channel Blocker
CHEBI has role	CHEBI:35620	vasodilator agents
CHEBI has role	CHEBI:35674	antihypertensive drugs
CHEBI has role	CHEBI:38215	calcium channel blockers
FDA MoA	N0000190114	Cytochrome P450 3A Inhibitors
MeSH PA	D000959	Antihypertensive Agents
MeSH PA	D002121	Calcium Channel Blockers
MeSH PA	D000077264	Calcium-Regulating Hormones and Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D049990	Membrane Transport Modulators
MeSH PA	D014665	Vasodilator Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Hypertensive disorder	indication	38341003	DOID:10763
Prinzmetal angina	indication	87343002
Angina pectoris	indication	194828000
Cerebrovascular accident	indication	230690007
Primary Prevention of Coronary Heart Disease	indication
Myocardial Infarction Prevention	indication
Anuria	contraindication	2472002	DOID:2983
Alcoholism	contraindication	7200002
Hyperkalemia	contraindication	14140009
Jaundice	contraindication	18165001
Secondary angle-closure glaucoma	contraindication	21571006
Hypovolemia	contraindication	28560003
Obstruction of bile duct	contraindication	30144000
Dehydration	contraindication	34095006
Hyperuricemia	contraindication	35885006	DOID:1920
Hypothyroidism	contraindication	40930008	DOID:1459
Angioedema	contraindication	41291007	DOID:1558
Hypokalemia	contraindication	43339004
Diabetes mellitus type 2	contraindication	44054006	DOID:9352
Low blood pressure	contraindication	45007003
Systemic lupus erythematosus	contraindication	55464009	DOID:9074
Sympathectomy	contraindication	57071006
Acute nephropathy	contraindication	58574008
Hepatic failure	contraindication	59927004
Hypercalcemia	contraindication	66931009	DOID:12678
Hyperparathyroidism	contraindication	66999008	DOID:13543
Hypochloremic alkalosis	contraindication	70134007
Hepatic coma	contraindication	72836002	DOID:12550
Diabetes mellitus	contraindication	73211009	DOID:9351
Chronic idiopathic constipation	contraindication	82934008
Hereditary angioneurotic edema	contraindication	82966003	DOID:14735
Hyponatremia	contraindication	89627008
Gout	contraindication	90560007	DOID:13189
Kidney disease	contraindication	90708001	DOID:557
Disorder of connective tissue	contraindication	105969002	DOID:65
Disorder of muscle	contraindication	129565002	DOID:423
Liver function tests abnormal	contraindication	166603001
Hypomagnesemia	contraindication	190855004
Acute pancreatitis	contraindication	197456007	DOID:2913
Impaired renal function disorder	contraindication	197663003
Hemorrhagic cerebral infarction	contraindication	230706003
Disease of liver	contraindication	235856003	DOID:409
Rhabdomyolysis	contraindication	240131006
Neonatal hyperbilirubinemia	contraindication	281610001
Pregnancy, function	contraindication	289908002
Renal artery stenosis	contraindication	302233006
Neutropenic disorder	contraindication	303011007	DOID:1227
Bone marrow depression	contraindication	307762000
Surgical procedure	contraindication	387713003
Breastfeeding (mother)	contraindication	413712001
Traumatic injury	contraindication	417746004
Azotemia	contraindication	445009001
Head and Neck Angioedema	contraindication
Hemodialysis with High-Flux Membrane	contraindication
Severe Aortic Valve Stenosis	contraindication
Intestinal Angioedema	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.0	Basic
pKa2	1.55	Basic

Orange Book patent data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
EQ 10MG BASE;14MG	PRESTALIA	ADHERA	N205003	Jan. 21, 2015	RX	TABLET	ORAL	6696481	April 15, 2023	TREATMENT OF HYPERTENSION
EQ 2.5MG BASE;3.5MG	PRESTALIA	ADHERA	N205003	Jan. 21, 2015	RX	TABLET	ORAL	6696481	April 15, 2023	TREATMENT OF HYPERTENSION
EQ 5MG BASE;7MG	PRESTALIA	ADHERA	N205003	Jan. 21, 2015	RX	TABLET	ORAL	6696481	April 15, 2023	TREATMENT OF HYPERTENSION
EQ 10MG BASE;200MG	CONSENSI	PURPLE BIOTECH	N210045	May 31, 2018	DISCN	TABLET	ORAL	9662315	May 22, 2029	TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 2.5MG BASE;200MG	CONSENSI	PURPLE BIOTECH	N210045	May 31, 2018	DISCN	TABLET	ORAL	9662315	May 22, 2029	TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 5MG BASE;200MG	CONSENSI	PURPLE BIOTECH	N210045	May 31, 2018	DISCN	TABLET	ORAL	9662315	May 22, 2029	TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 10MG BASE;14MG	PRESTALIA	ADHERA	N205003	Jan. 21, 2015	RX	TABLET	ORAL	7846961	Oct. 5, 2029	TREATMENT OF HYPERTENSION
EQ 2.5MG BASE;3.5MG	PRESTALIA	ADHERA	N205003	Jan. 21, 2015	RX	TABLET	ORAL	7846961	Oct. 5, 2029	TREATMENT OF HYPERTENSION
EQ 5MG BASE;7MG	PRESTALIA	ADHERA	N205003	Jan. 21, 2015	RX	TABLET	ORAL	7846961	Oct. 5, 2029	TREATMENT OF HYPERTENSION
EQ 10MG BASE;200MG	CONSENSI	PURPLE BIOTECH	N210045	May 31, 2018	DISCN	TABLET	ORAL	9408837	Feb. 28, 2030	TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 2.5MG BASE;200MG	CONSENSI	PURPLE BIOTECH	N210045	May 31, 2018	DISCN	TABLET	ORAL	9408837	Feb. 28, 2030	TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 5MG BASE;200MG	CONSENSI	PURPLE BIOTECH	N210045	May 31, 2018	DISCN	TABLET	ORAL	9408837	Feb. 28, 2030	TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 10MG BASE;200MG	CONSENSI	PURPLE BIOTECH	N210045	May 31, 2018	DISCN	TABLET	ORAL	10925835	June 14, 2038	TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 2.5MG BASE;200MG	CONSENSI	PURPLE BIOTECH	N210045	May 31, 2018	DISCN	TABLET	ORAL	10925835	June 14, 2038	TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 5MG BASE;200MG	CONSENSI	PURPLE BIOTECH	N210045	May 31, 2018	DISCN	TABLET	ORAL	10925835	June 14, 2038	TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 1MG BASE/ML	NORLIQVA	CMP DEV LLC	N214439	Feb. 24, 2022	RX	SOLUTION	ORAL	11253474	Feb. 24, 2041	NORLIQVA IS INDICATED FOR THE SYMPTOMATIC TREATMENT OF CHRONIC STABLE ANGINA
EQ 1MG BASE/ML	NORLIQVA	CMP DEV LLC	N214439	Feb. 24, 2022	RX	SOLUTION	ORAL	11253474	Feb. 24, 2041	NORLIQVA IS INDICATED FOR THE TREATMENT OF CONFIRMED OR SUSPECTED VASOSPASTIC ANGINA
EQ 1MG BASE/ML	NORLIQVA	CMP DEV LLC	N214439	Feb. 24, 2022	RX	SOLUTION	ORAL	11253474	Feb. 24, 2041	NORLIQVA IS INDICATED FOR THE TREATMENT OF HYPERTENSION, TO LOWER BLOOD PRESSURE IN ADULTS AND CHILDREN 6 YEARS OF AGE AND OLDER

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Voltage-dependent L-type calcium channel subunit alpha-1C	Ion channel	Q13936	CAC1C_HUMAN	BLOCKER			WOMBAT-PK	CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1D	Ion channel	Q01668	CAC1D_HUMAN	BLOCKER	Ki	7	WOMBAT-PK	CHEMBL
Alpha-1A adrenergic receptor	GPCR	P35348	ADA1A_HUMAN		Ki	5.63	CHEMBL
Aldehyde oxidase	Enzyme	Q06278	AOXA_HUMAN		IC50	5.26	WOMBAT-PK
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN		Ki	6.58	DRUG MATRIX
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN		Ki	5.36	DRUG MATRIX
Alpha-1D adrenergic receptor	GPCR	P25100	ADA1D_HUMAN		Ki	5.27	CHEMBL
Alpha-1B adrenergic receptor	GPCR	P35368	ADA1B_HUMAN		Ki	5.10	CHEMBL
Voltage-dependent calcium channel gamma-1 subunit	Ion channel	Q06432	CCG1_HUMAN		Ki	7.20	WOMBAT-PK
Carbonic anhydrase 1	Enzyme	P00915	CAH1_HUMAN				WOMBAT-PK
Voltage-dependent calcium channel subunit alpha-2/delta-1	Ion channel	P54289	CA2D1_HUMAN		Ki	7.20	WOMBAT-PK
Voltage-dependent T-type calcium channel subunit alpha-1H	Ion channel	O95180	CAC1H_HUMAN		Ki	4.51	WOMBAT-PK
Potassium channel subfamily K member 2	Ion channel	O95069	KCNK2_HUMAN		IC50	6.40	CHEMBL
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	6.65	DRUG MATRIX
5-hydroxytryptamine receptor 6	GPCR	P50406	5HT6R_HUMAN		Ki	5.87	DRUG MATRIX
Voltage-dependent L-type calcium channel subunit alpha-1C	Ion channel		CAC1C_RAT		Ki	8.70	CHEMBL
Potassium channel subfamily K member 2	Ion channel		Q8HY88_BOVIN		IC50	6.37	CHEMBL

External reference:

ID	Source
4020813	VUID
N0000148333	NUI
D00615	KEGG_DRUG
111470-99-6	SECONDARY_CAS_RN
88150-47-4	SECONDARY_CAS_RN
104416	RXNORM
C0051696	UMLSCUI
CHEBI:2669	CHEBI
06X	PDB_CHEM_ID
CHEMBL1491	ChEMBL_ID
CHEMBL1200402	ChEMBL_ID
D017311	MESH_DESCRIPTOR_UI
DB00381	DRUGBANK_ID
2162	PUBCHEM_CID
6981	IUPHAR_LIGAND_ID
5729	INN_ID
246852-12-0	SECONDARY_CAS_RN
1J444QC288	UNII
108736	MMSL
173594	MMSL
23944	MMSL
27341	MMSL
4180	MMSL
d00689	MMSL
003672	NDDF
003673	NDDF
008599	NDDF
015579	NDDF
4020586	VANDF
4020813	VANDF
CHEMBL1200984	ChEMBL_ID
108537001	SNOMEDCT_US
1193663008	SNOMEDCT_US
384976003	SNOMEDCT_US
386864001	SNOMEDCT_US
421048000	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Norvasc	HUMAN PRESCRIPTION DRUG LABEL	1	0069-1520	TABLET	2.50 mg	ORAL	NDA	26 sections
Norvasc	HUMAN PRESCRIPTION DRUG LABEL	1	0069-1520	TABLET	2.50 mg	ORAL	NDA	26 sections
Norvasc	HUMAN PRESCRIPTION DRUG LABEL	1	0069-1530	TABLET	5 mg	ORAL	NDA	26 sections
Norvasc	HUMAN PRESCRIPTION DRUG LABEL	1	0069-1530	TABLET	5 mg	ORAL	NDA	26 sections
Norvasc	HUMAN PRESCRIPTION DRUG LABEL	1	0069-1540	TABLET	10 mg	ORAL	NDA	26 sections
Norvasc	HUMAN PRESCRIPTION DRUG LABEL	1	0069-1540	TABLET	10 mg	ORAL	NDA	26 sections
Caduet	HUMAN PRESCRIPTION DRUG LABEL	2	0069-2150	TABLET, FILM COATED	5 mg	ORAL	NDA	32 sections
Caduet	HUMAN PRESCRIPTION DRUG LABEL	2	0069-2150	TABLET, FILM COATED	5 mg	ORAL	NDA	32 sections
Caduet	HUMAN PRESCRIPTION DRUG LABEL	2	0069-2160	TABLET, FILM COATED	10 mg	ORAL	NDA	32 sections
Caduet	HUMAN PRESCRIPTION DRUG LABEL	2	0069-2160	TABLET, FILM COATED	10 mg	ORAL	NDA	32 sections
Caduet	HUMAN PRESCRIPTION DRUG LABEL	2	0069-2170	TABLET, FILM COATED	5 mg	ORAL	NDA	32 sections
Caduet	HUMAN PRESCRIPTION DRUG LABEL	2	0069-2170	TABLET, FILM COATED	5 mg	ORAL	NDA	32 sections
Caduet	HUMAN PRESCRIPTION DRUG LABEL	2	0069-2180	TABLET, FILM COATED	10 mg	ORAL	NDA	32 sections
Caduet	HUMAN PRESCRIPTION DRUG LABEL	2	0069-2180	TABLET, FILM COATED	10 mg	ORAL	NDA	32 sections
Caduet	HUMAN PRESCRIPTION DRUG LABEL	2	0069-2190	TABLET, FILM COATED	5 mg	ORAL	NDA	32 sections
Caduet	HUMAN PRESCRIPTION DRUG LABEL	2	0069-2190	TABLET, FILM COATED	5 mg	ORAL	NDA	32 sections
Caduet	HUMAN PRESCRIPTION DRUG LABEL	2	0069-2250	TABLET, FILM COATED	10 mg	ORAL	NDA	32 sections
Caduet	HUMAN PRESCRIPTION DRUG LABEL	2	0069-2250	TABLET, FILM COATED	10 mg	ORAL	NDA	32 sections
Caduet	HUMAN PRESCRIPTION DRUG LABEL	2	0069-2260	TABLET, FILM COATED	5 mg	ORAL	NDA	32 sections
Caduet	HUMAN PRESCRIPTION DRUG LABEL	2	0069-2260	TABLET, FILM COATED	5 mg	ORAL	NDA	32 sections
Caduet	HUMAN PRESCRIPTION DRUG LABEL	2	0069-2270	TABLET, FILM COATED	10 mg	ORAL	NDA	32 sections
Caduet	HUMAN PRESCRIPTION DRUG LABEL	2	0069-2270	TABLET, FILM COATED	10 mg	ORAL	NDA	32 sections
Caduet	HUMAN PRESCRIPTION DRUG LABEL	2	0069-2960	TABLET, FILM COATED	2.50 mg	ORAL	NDA	32 sections
Caduet	HUMAN PRESCRIPTION DRUG LABEL	2	0069-2970	TABLET, FILM COATED	2.50 mg	ORAL	NDA	32 sections
Caduet	HUMAN PRESCRIPTION DRUG LABEL	2	0069-2980	TABLET, FILM COATED	2.50 mg	ORAL	NDA	32 sections
Caduet	HUMAN PRESCRIPTION DRUG LABEL	2	0069-6180	TABLET, FILM COATED	5 mg	ORAL	NDA	32 sections
Caduet	HUMAN PRESCRIPTION DRUG LABEL	2	0069-6323	TABLET, FILM COATED	5 mg	ORAL	NDA	32 sections
Caduet	HUMAN PRESCRIPTION DRUG LABEL	2	0069-6565	TABLET, FILM COATED	5 mg	ORAL	NDA	32 sections
Caduet	HUMAN PRESCRIPTION DRUG LABEL	2	0069-6747	TABLET, FILM COATED	5 mg	ORAL	NDA	32 sections
Caduet	HUMAN PRESCRIPTION DRUG LABEL	2	0069-7232	TABLET, FILM COATED	10 mg	ORAL	NDA	32 sections