mofezolac Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibufenac derivatives 1829 78967-07-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • N-22
  • mofezolac
Cyclooxygenase 1 inhibitor; ; RN from Toxlit
  • Molecular weight: 339.35
  • Formula: C19H17NO5
  • CLOGP: 2.51
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 81.79
  • ALOGS: -3.84
  • ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None PMDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.86 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 1 Enzyme IC50 8.85 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 6.36 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 8.85 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 6.36 CHEMBL

External reference:

IDSource
C0043597 UMLSCUI
D01718 KEGG_DRUG
11469 RXNORM
008241 NDDF
CHEMBL259972 ChEMBL_ID
RVJ0BV3H3Y UNII
6701 INN_ID
63X PDB_CHEM_ID
CHEBI:31860 CHEBI
C054999 MESH_SUPPLEMENTAL_RECORD_UI
4237 PUBCHEM_CID

Pharmaceutical products:

None