modafinil ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1826 68693-11-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • modafinil
  • (+/-)-Modafinil
  • modaphonil
  • modiodal
A benzhydryl acetamide compound, central nervous system stimulant, and CYP3A4 inducing agent that is used in the treatment of NARCOLEPSY and SLEEP WAKE DISORDERS.
  • Molecular weight: 273.35
  • Formula: C15H15NO2S
  • CLOGP: 0.94
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 60.16
  • ALOGS: -2.64
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 8 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 20.90 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 80 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Dec. 24, 1998 FDA CEPHALON
Feb. 21, 2020 PMDA Alfresa Pharma Corporation

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Multiple sclerosis relapse 381.63 11.20 260 28349 42704 50533811
Multiple sclerosis 258.97 11.20 155 28454 20338 50556177
Cataplexy 207.54 11.20 58 28551 1008 50575507
Pre-existing condition improved 197.20 11.20 91 28518 7006 50569509
Depression 192.15 11.20 339 28270 165084 50411431
Sleep apnoea syndrome 160.32 11.20 122 28487 23746 50552769
Suicidal ideation 129.33 11.20 158 28451 55227 50521288
Anxiety 122.92 11.20 294 28315 177312 50399203
Somnambulism 80.27 11.20 44 28565 4880 50571635
Joint swelling 72.80 11.20 24 28585 245262 50331253
Somnolence 65.00 11.20 214 28395 154771 50421744
Influenza like illness 64.26 11.20 116 28493 57343 50519172
Balance disorder 60.06 11.20 127 28482 70463 50506052
Migraine 57.86 11.20 130 28479 75150 50501365
Synovitis 57.65 11.20 3 28606 123862 50452653
Gait disturbance 53.23 11.20 196 28413 149809 50426706
Treatment failure 51.70 11.20 8 28601 137629 50438886
Memory impairment 51.18 11.20 128 28481 79232 50497283
Rheumatoid arthritis 50.10 11.20 26 28583 202524 50373991
Fall 49.96 11.20 342 28267 334590 50241925
Infusion related reaction 49.56 11.20 17 28592 169540 50406975
Snoring 49.06 11.20 28 28581 3356 50573159
Enuresis 49.04 11.20 24 28585 2105 50574410
Off label use 48.14 11.20 125 28484 474301 50102214
Muscle spasticity 46.67 11.20 53 28556 17131 50559384
Therapeutic response unexpected 46.51 11.20 51 28558 15864 50560651
Hand deformity 44.88 11.20 3 28606 100196 50476319
Death 42.78 11.20 74 28535 325305 50251210
Psychotic disorder 41.11 11.20 56 28553 21756 50554759
Glossodynia 40.59 11.20 8 28601 115561 50460954
Acute kidney injury 38.84 11.20 43 28566 228015 50348500
Seizure 38.46 11.20 150 28459 117724 50458791
Lower respiratory tract infection 36.98 11.20 5 28604 95196 50481319
Feeling abnormal 36.42 11.20 154 28455 125338 50451177
Narcolepsy 35.77 11.20 16 28593 1144 50575371
Magnetic resonance imaging abnormal 35.46 11.20 21 28588 2697 50573818
Pregnancy on oral contraceptive 35.37 11.20 15 28594 943 50575572
Hypoaesthesia 35.27 11.20 154 28455 127103 50449412
Disturbance in attention 34.90 11.20 63 28546 31123 50545392
Heart rate 34.86 11.20 8 28601 59 50576456
Major depression 33.15 11.20 29 28580 6855 50569660
Stress 32.83 11.20 85 28524 53708 50522807
Blood pressure measurement 32.78 11.20 10 28599 239 50576276
Rash 32.67 11.20 132 28477 437339 50139176
Sleep paralysis 32.54 11.20 12 28597 520 50575995
Blood pressure increased 32.35 11.20 155 28454 132977 50443538
Feeling drunk 32.12 11.20 22 28587 3631 50572884
Tremor 31.80 11.20 139 28470 114764 50461751
Urinary incontinence 31.58 11.20 57 28552 28151 50548364
Drug ineffective 31.20 11.20 305 28304 819028 49757487
Muscular weakness 31.06 11.20 121 28488 94892 50481623
Neutropenia 31.02 11.20 23 28586 147942 50428573
Dysstasia 30.96 11.20 44 28565 17775 50558740
Systemic lupus erythematosus 30.60 11.20 21 28588 140601 50435914
Restless legs syndrome 30.23 11.20 41 28568 15856 50560659
Hypnagogic hallucination 29.35 11.20 8 28601 126 50576389
Polycystic ovaries 29.32 11.20 18 28591 2466 50574049
Thrombocytopenia 29.23 11.20 18 28591 127655 50448860
Pericarditis 28.58 11.20 5 28604 78684 50497831
Secondary progressive multiple sclerosis 28.35 11.20 14 28595 1252 50575263
Parasomnia 28.07 11.20 10 28599 392 50576123
Hypersensitivity vasculitis 28.00 11.20 21 28588 3994 50572521
General physical health deterioration 27.53 11.20 24 28585 142410 50434105
Insomnia 27.45 11.20 181 28428 174684 50401831
Pancytopenia 27.13 11.20 7 28602 84023 50492492
Wound 27.01 11.20 13 28596 105781 50470734
Diarrhoea 26.80 11.20 209 28400 588267 49988248
Histoplasmosis 26.70 11.20 15 28594 1744 50574771
Arthropathy 26.62 11.20 30 28579 157876 50418639
Febrile neutropenia 26.50 11.20 11 28598 97656 50478859
Product use issue 25.63 11.20 28 28581 149447 50427068
Abnormal dreams 25.59 11.20 29 28580 9348 50567167
Substance use 25.56 11.20 9 28600 341 50576174
Malignant neoplasm progression 25.48 11.20 4 28605 68120 50508395
Mania 25.22 11.20 31 28578 10885 50565630
Muscle spasms 24.81 11.20 138 28471 125415 50451100
Irritability 23.99 11.20 51 28558 28375 50548140
Amnesia 23.98 11.20 65 28544 42195 50534320
Hypersomnia 23.97 11.20 36 28573 15278 50561237
Bipolar disorder 23.93 11.20 24 28585 6733 50569782
Central nervous system lesion 23.64 11.20 28 28581 9461 50567054
Paranoia 23.28 11.20 29 28580 10319 50566196
Drug intolerance 22.71 11.20 57 28552 219047 50357468
Intervertebral disc protrusion 22.56 11.20 41 28568 20352 50556163
Enterococcal sepsis 22.47 11.20 12 28597 1263 50575252
Hallucination, auditory 22.45 11.20 29 28580 10699 50565816
Lymphocyte count decreased 21.97 11.20 47 28562 26260 50550255
Surgery 21.90 11.20 51 28558 30154 50546361
Hypertension 21.65 11.20 198 28411 211005 50365510
Hypnopompic hallucination 21.54 11.20 5 28604 39 50576476
Panic attack 21.54 11.20 39 28570 19303 50557212
Alopecia 21.53 11.20 69 28540 244978 50331537
White blood cells urine positive 21.47 11.20 19 28590 4559 50571956
Weight decreased 20.98 11.20 204 28405 221041 50355474
Loss of consciousness 20.81 11.20 115 28494 104238 50472277
Product use in unapproved indication 20.63 11.20 21 28588 115798 50460717
Anaemia 20.20 11.20 74 28535 252382 50324133
Optic neuritis 19.99 11.20 22 28587 6868 50569647
Asthma exercise induced 19.78 11.20 7 28602 269 50576246
Abnormal sleep-related event 19.42 11.20 9 28600 699 50575816
Vision blurred 19.40 11.20 92 28517 78555 50497960
Paraesthesia 19.18 11.20 125 28484 120118 50456397
Hangover 18.82 11.20 11 28598 1378 50575137
Peripheral swelling 18.78 11.20 57 28552 205879 50370636
Sleep-related eating disorder 18.72 11.20 9 28600 759 50575756
Disease progression 18.70 11.20 16 28593 95850 50480665
Headache 18.61 11.20 395 28214 506140 50070375
Post-traumatic stress disorder 18.49 11.20 17 28592 4286 50572229
Abdominal discomfort 18.46 11.20 68 28541 231573 50344942
Cardiac failure 18.42 11.20 10 28599 76030 50500485
Dyskinesia 18.01 11.20 45 28564 27816 50548699
Injection site scar 17.86 11.20 9 28600 840 50575675
Withdrawal syndrome 17.75 11.20 34 28575 17556 50558959
Postural orthostatic tachycardia syndrome 17.64 11.20 9 28600 863 50575652
Pneumonia 17.35 11.20 134 28475 378267 50198248
Platelet count decreased 17.11 11.20 19 28590 100707 50475808
Incoherent 16.81 11.20 16 28593 4214 50572301
Trigeminal neuralgia 16.79 11.20 14 28595 3101 50573414
Hunger 16.70 11.20 16 28593 4247 50572268
Progressive multifocal leukoencephalopathy 16.62 11.20 26 28583 11431 50565084
Crying 16.50 11.20 36 28573 20380 50556135
Dizziness 16.44 11.20 281 28328 346088 50230427
Urinary tract infection 16.33 11.20 196 28413 223824 50352691
Oedema mouth 16.02 11.20 12 28597 2278 50574237
Abdominal pain 15.92 11.20 74 28535 236154 50340361
C-reactive protein increased 15.73 11.20 9 28600 66465 50510050
Haemoglobin decreased 15.72 11.20 30 28579 127186 50449329
Drug withdrawal syndrome 15.68 11.20 40 28569 25041 50551474
Lymphopenia 15.53 11.20 30 28579 15591 50560924
Cervical spinal stenosis 15.44 11.20 11 28598 1932 50574583
Endometriosis 15.41 11.20 15 28594 4060 50572455
Movement disorder 15.30 11.20 32 28577 17600 50558915
Coordination abnormal 15.12 11.20 25 28584 11509 50565006
International normalised ratio increased 15.12 11.20 3 28606 43149 50533366
Depersonalisation/derealisation disorder 14.96 11.20 9 28600 1189 50575326
Spinal operation 14.82 11.20 18 28591 6242 50570273
Peroneal nerve palsy 14.78 11.20 15 28594 4268 50572247
Arthralgia 14.69 11.20 168 28441 438534 50137981
Blister 14.63 11.20 16 28593 85402 50491113
Urine analysis abnormal 14.59 11.20 15 28594 4335 50572180
Road traffic accident 14.36 11.20 38 28571 24314 50552201
Renal impairment 14.31 11.20 13 28596 75648 50500867
Cognitive disorder 14.25 11.20 56 28553 44067 50532448
Periodic limb movement disorder 14.23 11.20 5 28604 188 50576327
Illness 14.17 11.20 38 28571 24502 50552013
Brachial plexus injury 14.07 11.20 3 28606 15 50576500
CD4 lymphocytes decreased 14.04 11.20 9 28600 1330 50575185
Nephrolithiasis 13.70 11.20 47 28562 34646 50541869
Apnoea 13.30 11.20 18 28591 6948 50569567
Bruxism 13.04 11.20 12 28597 3028 50573487
Paralysis 13.04 11.20 20 28589 8644 50567871
Hysterectomy 13.00 11.20 19 28590 7871 50568644
Premenstrual dysphoric disorder 12.97 11.20 3 28606 23 50576492
Neuralgia 12.77 11.20 34 28575 21829 50554686
Relapsing-remitting multiple sclerosis 12.77 11.20 6 28603 481 50576034
Haemoglobin urine present 12.58 11.20 7 28602 799 50575716
Loss of bladder sensation 12.54 11.20 3 28606 27 50576488
Nausea 12.52 11.20 502 28107 704896 49871619
Stomatitis 12.43 11.20 24 28585 101320 50475195
Invasive ductal breast carcinoma 12.38 11.20 16 28593 5905 50570610
Swelling 12.34 11.20 65 28544 200807 50375708
Bladder disorder 12.19 11.20 18 28591 7525 50568990
Discomfort 12.17 11.20 27 28582 108353 50468162
Muscle injury 12.15 11.20 3 28606 37108 50539407
Perinatal depression 11.96 11.20 6 28603 555 50575960
Loss of control of legs 11.83 11.20 8 28601 1293 50575222
Septic shock 11.83 11.20 9 28600 57166 50519349
Therapeutic product effect incomplete 11.82 11.20 21 28588 91494 50485021
B-lymphocyte count decreased 11.79 11.20 7 28602 903 50575612
Neurogenic bladder 11.72 11.20 11 28598 2846 50573669
Urine leukocyte esterase positive 11.64 11.20 11 28598 2872 50573643
Meniscus injury 11.60 11.20 16 28593 6286 50570229
Uterine leiomyoma 11.57 11.20 18 28591 7873 50568642
Fatigue 11.52 11.20 499 28110 707102 49869413
Laboratory test abnormal 11.50 11.20 34 28575 23174 50553341
Therapeutic product effect decreased 11.45 11.20 39 28570 136011 50440504
Unevaluable event 11.44 11.20 54 28555 46012 50530503
Delusion of grandeur 11.42 11.20 4 28605 149 50576366
Urinary sediment 11.34 11.20 3 28606 42 50576473
Tardive dyskinesia 11.23 11.20 17 28592 7262 50569253
Attention deficit hyperactivity disorder 11.23 11.20 10 28599 2419 50574096
Transient acantholytic dermatosis 11.21 11.20 3 28606 44 50576471

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cataplexy 158.34 14.74 33 10899 239 29563356
Sleep apnoea syndrome 153.27 14.74 90 10842 17509 29546086
Pre-existing condition improved 135.46 14.74 45 10887 2208 29561387
Multiple sclerosis relapse 98.34 14.74 58 10874 11361 29552234
Anxiety 76.28 14.74 123 10809 85242 29478353
Suicidal ideation 75.80 14.74 78 10854 34638 29528957
Multiple sclerosis 75.01 14.74 38 10894 5516 29558079
Depression 73.79 14.74 121 10811 85026 29478569
Therapeutic response unexpected 72.08 14.74 43 10889 8595 29555000
Somnolence 49.51 14.74 108 10824 93847 29469748
Tic 48.37 14.74 20 10912 1815 29561780
Sleep paralysis 45.82 14.74 11 10921 160 29563435
Obsessive-compulsive disorder 44.05 14.74 25 10907 4551 29559044
Bipolar disorder 42.90 14.74 22 10910 3273 29560322
Memory impairment 41.68 14.74 59 10873 36411 29527184
Cognitive disorder 41.11 14.74 47 10885 23452 29540143
Narcolepsy 38.73 14.74 12 10920 469 29563126
Migraine 38.68 14.74 34 10898 12396 29551199
Acute kidney injury 36.47 14.74 27 10905 265240 29298355
Psychotic disorder 36.09 14.74 41 10891 20313 29543282
Delusion 33.55 14.74 30 10902 11186 29552409
Foetal malnutrition 32.97 14.74 7 10925 56 29563539
Somnambulism 31.64 14.74 17 10915 2781 29560814
Tourette's disorder 31.48 14.74 7 10925 71 29563524
Feeling abnormal 31.43 14.74 65 10867 54380 29509215
Insomnia 29.81 14.74 86 10846 88675 29474920
Anaemia 29.52 14.74 19 10913 200932 29362663
Mania 27.56 14.74 24 10908 8639 29554956
Road traffic accident 27.00 14.74 31 10901 15530 29548065
Wrong dose 26.86 14.74 9 10923 453 29563142
Paranoia 26.77 14.74 25 10907 9852 29553743
Headache 26.71 14.74 131 10801 173876 29389719
Irritability 25.53 14.74 36 10896 22116 29541479
Concussion 24.74 14.74 13 10919 2033 29561562
Neutropenia 24.57 14.74 9 10923 131702 29431893
Foetal hypokinesia 24.52 14.74 8 10924 370 29563225
Condition aggravated 24.52 14.74 113 10819 146182 29417413
Fall 24.13 14.74 129 10803 177049 29386546
Thrombocytopenia 23.85 14.74 10 10922 134813 29428782
Gait disturbance 23.59 14.74 70 10862 73279 29490316
Aggression 23.59 14.74 45 10887 35496 29528099
Abnormal sleep-related event 23.05 14.74 8 10924 448 29563147
Hypertension 22.51 14.74 94 10838 116520 29447075
Abnormal dreams 21.67 14.74 19 10913 6901 29556694
Post-traumatic stress disorder 21.61 14.74 11 10921 1611 29561984
Renal failure 20.65 14.74 9 10923 118590 29445005
Trismus 20.27 14.74 12 10920 2361 29561234
Psychotic symptom 20.04 14.74 10 10922 1404 29562191
Death 19.05 14.74 64 10868 342020 29221575
Blood pressure increased 18.78 14.74 65 10867 73738 29489857
Post concussion syndrome 18.55 14.74 5 10927 118 29563477
Hypotension 17.55 14.74 28 10904 194326 29369269
Blood cholesterol increased 17.46 14.74 25 10907 15570 29548025
Magical thinking 17.42 14.74 3 10929 6 29563589
Schizotypal personality disorder 17.42 14.74 3 10929 6 29563589
Hypnagogic hallucination 16.94 14.74 4 10928 54 29563541
Urinary tract infection 16.93 14.74 62 10870 72292 29491303
Secondary progressive multiple sclerosis 16.92 14.74 6 10926 358 29563237
Hallucination, auditory 16.45 14.74 19 10913 9574 29554021
Influenza like illness 16.25 14.74 31 10901 24439 29539156
Pulmonary hypoplasia 16.00 14.74 6 10926 420 29563175
Rib hypoplasia 15.89 14.74 3 10929 12 29563583
Pyrexia 15.86 14.74 54 10878 287568 29276027
Antiphospholipid antibodies 15.34 14.74 3 10929 15 29563580
Disturbance in attention 15.30 14.74 28 10904 21396 29542199

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Multiple sclerosis relapse 381.79 12.08 231 27411 40904 64430186
Multiple sclerosis 281.45 12.08 145 27497 18796 64452294
Cataplexy 268.67 12.08 64 27578 767 64470323
Depression 148.83 12.08 275 27367 183016 64288074
Pre-existing condition improved 108.83 12.08 49 27593 4713 64466377
Sleep apnoea syndrome 94.65 12.08 88 27554 29744 64441346
Anxiety 92.25 12.08 241 27401 202408 64268682
Memory impairment 80.28 12.08 137 27505 85545 64385545
Suicidal ideation 74.01 12.08 115 27527 66427 64404663
Fall 73.64 12.08 363 27279 416463 64054627
Acute kidney injury 68.96 12.08 55 27587 449185 64021905
Gait disturbance 64.71 12.08 191 27451 171964 64299126
Somnolence 64.61 12.08 213 27429 203432 64267658
Muscle spasticity 58.40 12.08 52 27590 16617 64454473
Psychotic disorder 53.56 12.08 70 27572 34508 64436582
Migraine 53.22 12.08 96 27546 62581 64408509
Influenza like illness 53.02 12.08 95 27547 61607 64409483
Narcolepsy 51.86 12.08 19 27623 1072 64470018
Sleep paralysis 51.50 12.08 16 27626 542 64470548
Urinary tract infection 51.46 12.08 216 27426 231380 64239710
Tic 50.63 12.08 24 27618 2595 64468495
Febrile neutropenia 49.67 12.08 10 27632 187647 64283443
Therapeutic response unexpected 47.93 12.08 47 27595 16954 64454136
Feeling abnormal 47.13 12.08 145 27497 133457 64337633
Insomnia 46.69 12.08 188 27454 197648 64273442
Balance disorder 45.71 12.08 107 27535 83819 64387271
Thrombocytopenia 43.12 12.08 21 27621 223780 64247310
Hypoaesthesia 42.74 12.08 144 27498 138964 64332126
Mania 42.19 12.08 43 27599 16243 64454847
Abnormal dreams 41.73 12.08 35 27607 10321 64460769
Somnambulism 40.39 12.08 26 27616 5115 64465975
Headache 40.19 12.08 374 27268 529093 63941997
Feeling drunk 40.15 12.08 24 27618 4143 64466947
Neutropenia 39.73 12.08 27 27615 239597 64231493
Obsessive-compulsive disorder 39.42 12.08 25 27617 4793 64466297
Secondary progressive multiple sclerosis 38.98 12.08 16 27626 1227 64469863
Off label use 38.28 12.08 141 27501 632665 63838425
Death 38.17 12.08 95 27547 482610 63988480
Magnetic resonance imaging abnormal 38.16 12.08 21 27621 3102 64467988
Anaemia 37.99 12.08 65 27577 378615 64092475
Cognitive disorder 37.69 12.08 77 27565 55010 64416080
Heart rate 37.43 12.08 8 27634 56 64471034
Joint swelling 37.43 12.08 23 27619 215359 64255731
Seizure 36.53 12.08 155 27487 166737 64304353
Hypnagogic hallucination 35.48 12.08 9 27633 142 64470948
General physical health deterioration 35.29 12.08 22 27620 204403 64266687
Blood pressure measurement 35.06 12.08 11 27631 385 64470705
Enuresis 34.75 12.08 19 27623 2771 64468319
Malignant neoplasm progression 34.44 12.08 4 27638 112867 64358223
Rheumatoid arthritis 33.86 12.08 14 27628 164280 64306810
Hyperkalaemia 32.36 12.08 3 27639 101126 64369964
Delusion 31.91 12.08 39 27603 17975 64453115
Muscle spasms 31.65 12.08 132 27510 140891 64330199
Pregnancy on oral contraceptive 31.44 12.08 12 27630 759 64470331
Tourette's disorder 29.76 12.08 7 27635 79 64471011
Bipolar disorder 29.65 12.08 24 27618 6737 64464353
Hallucination, auditory 28.92 12.08 36 27606 16903 64454187
Renal impairment 28.64 12.08 11 27631 135006 64336084
Pancytopenia 28.27 12.08 13 27629 143296 64327794
Treatment failure 27.43 12.08 8 27634 116808 64354282
Urinary incontinence 26.48 12.08 52 27590 36099 64434991
Disease progression 26.22 12.08 14 27628 141666 64329424
Cardiac failure 26.13 12.08 12 27630 132361 64338729
Hypersomnia 26.10 12.08 37 27605 19680 64451410
Road traffic accident 25.97 12.08 47 27595 30698 64440392
Histoplasmosis 25.82 12.08 14 27628 2008 64469082
Fatigue 25.82 12.08 457 27185 748273 63722817
Renal failure 25.67 12.08 24 27618 181664 64289426
Progressive multifocal leukoencephalopathy 25.31 12.08 35 27607 18197 64452893
Stress 24.47 12.08 69 27573 60465 64410625
Dysstasia 24.24 12.08 39 27603 23176 64447914
Hypotension 24.23 12.08 83 27559 380891 64090199
Product use in unapproved indication 24.17 12.08 24 27618 176594 64294496
Optic neuritis 23.93 12.08 23 27619 8093 64462997
Irritability 23.53 12.08 50 27592 36696 64434394
Snoring 23.50 12.08 18 27624 4664 64466426
Hypersensitivity vasculitis 23.50 12.08 21 27621 6740 64464350
White blood cells urine positive 23.33 12.08 19 27623 5379 64465711
Disturbance in attention 23.04 12.08 53 27589 41021 64430069
Panic attack 22.98 12.08 36 27606 20917 64450173
Wrong dose 22.86 12.08 11 27631 1230 64469860
Concussion 22.48 12.08 22 27620 7916 64463174
Muscular weakness 22.44 12.08 111 27531 127227 64343863
Vision blurred 22.21 12.08 87 27555 90229 64380861
Amnesia 21.48 12.08 57 27585 48212 64422878
Hangover 21.10 12.08 12 27630 1889 64469201
Blood pressure increased 20.88 12.08 136 27506 172416 64298674
Abnormal behaviour 20.67 12.08 45 27597 33577 64437513
Infusion related reaction 20.67 12.08 24 27618 164443 64306647
Interstitial lung disease 20.66 12.08 8 27634 97724 64373366
Hunger 20.49 12.08 16 27626 4265 64466825
Dyskinesia 20.12 12.08 49 27593 39339 64431751
Loss of consciousness 19.86 12.08 120 27522 148245 64322845
Psychotic symptom 19.79 12.08 12 27630 2126 64468964
Lower respiratory tract infection 19.58 12.08 8 27634 94606 64376484
International normalised ratio increased 19.37 12.08 5 27637 79162 64391928
Laboratory test abnormal 19.33 12.08 36 27606 24027 64447063
Attention deficit hyperactivity disorder 19.30 12.08 13 27629 2757 64468333
Tremor 19.28 12.08 119 27523 148111 64322979
Substance use 19.26 12.08 8 27634 632 64470458
Paranoia 19.20 12.08 29 27613 16323 64454767
Lymphocyte count decreased 19.07 12.08 49 27593 40650 64430440
Oedema mouth 18.87 12.08 13 27629 2860 64468230
Septic shock 18.67 12.08 11 27631 105426 64365664
Platelet count decreased 18.48 12.08 27 27615 167684 64303406
Urine analysis abnormal 18.29 12.08 17 27625 5739 64465351
Restless legs syndrome 18.21 12.08 29 27613 17087 64454003
Enterococcal sepsis 18.09 12.08 12 27630 2482 64468608
Suicide attempt 17.94 12.08 69 27573 70938 64400152
Nervousness 17.54 12.08 39 27603 29517 64441573
Peroneal nerve palsy 17.46 12.08 16 27626 5305 64465785
Pneumonia 17.30 12.08 155 27487 559421 63911669
Nausea 17.14 12.08 449 27193 785351 63685739
Magical thinking 16.97 12.08 3 27639 6 64471084
Endometriosis 16.86 12.08 12 27630 2780 64468310
Breast cancer 16.78 12.08 38 27604 29110 64441980
Diarrhoea 16.78 12.08 214 27428 722490 63748600
Haemoglobin decreased 16.48 12.08 37 27605 195026 64276064
Schizotypal personality disorder 16.11 12.08 3 27639 9 64471081
Drug withdrawal syndrome 16.06 12.08 39 27603 31252 64439838
Hepatic function abnormal 15.85 12.08 4 27638 64309 64406781
Sleep attacks 15.83 12.08 5 27637 179 64470911
Blood creatinine increased 15.81 12.08 21 27621 135761 64335329
Bladder disorder 15.71 12.08 18 27624 7749 64463341
Hypnopompic hallucination 15.66 12.08 4 27638 65 64471025
Paraesthesia 15.64 12.08 105 27537 134417 64336673
Central nervous system lesion 15.34 12.08 22 27620 11827 64459263
Movement disorder 15.34 12.08 31 27611 21969 64449121
Cervical spinal stenosis 15.30 12.08 10 27632 2019 64469071
Incoherent 15.26 12.08 17 27625 7101 64463989
Injection site scar 15.20 12.08 7 27635 709 64470381
Pericarditis 15.19 12.08 4 27638 62512 64408578
Dizziness 14.91 12.08 263 27379 429900 64041190
Tardive dyskinesia 14.86 12.08 19 27623 9159 64461931
B-lymphocyte count decreased 14.72 12.08 8 27634 1153 64469937
Depersonalisation/derealisation disorder 14.65 12.08 9 27633 1631 64469459
Post-traumatic stress disorder 14.49 12.08 13 27629 4192 64466898
Electrocardiogram QT prolonged 14.47 12.08 8 27634 79440 64391650
Invasive ductal breast carcinoma 14.32 12.08 14 27628 5028 64466062
Glossodynia 14.17 12.08 5 27637 64691 64406399
Rash 14.16 12.08 127 27515 458422 64012668
Haemoglobin urine present 13.96 12.08 7 27635 856 64470234
Nightmare 13.95 12.08 29 27613 20964 64450126
Head injury 13.83 12.08 38 27604 32804 64438286
Trigeminal neuralgia 13.55 12.08 11 27631 3098 64467992
Intervertebral disc protrusion 13.54 12.08 28 27614 20163 64450927
Muscle tightness 13.46 12.08 20 27622 11095 64459995
Product substitution issue 13.45 12.08 26 27616 17835 64453255
Urine abnormality 13.14 12.08 16 27626 7346 64463744
Dyspnoea 13.12 12.08 223 27419 718451 63752639
Haematochezia 13.12 12.08 6 27636 66367 64404723
Oxygen saturation decreased 13.08 12.08 16 27626 107160 64363930
Euphoric mood 12.87 12.08 15 27627 6576 64464514
C-reactive protein increased 12.86 12.08 13 27629 94896 64376194
Hypoaesthesia oral 12.84 12.08 20 27622 11560 64459530
Withdrawal syndrome 12.83 12.08 30 27612 23462 64447628
Flushing 12.76 12.08 67 27575 78581 64392509
Haematuria 12.70 12.08 5 27637 60466 64410624
Urine leukocyte esterase positive 12.69 12.08 11 27631 3392 64467698
Condition aggravated 12.65 12.08 227 27415 372199 64098891
Extra dose administered 12.58 12.08 15 27627 6735 64464355
Erythema 12.39 12.08 40 27602 187030 64284060
Poor quality sleep 12.38 12.08 26 27616 18925 64452165
Urinary sediment 12.37 12.08 3 27639 39 64471051
Somatic delusion 12.36 12.08 6 27636 684 64470406
Relapsing-remitting multiple sclerosis 12.31 12.08 7 27635 1101 64469989
Dihydrotestosterone increased 12.16 12.08 3 27639 42 64471048
Lymphopenia 12.13 12.08 31 27611 25626 64445464
Neurogenic bladder 12.10 12.08 11 27631 3608 64467482

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N06BA07 NERVOUS SYSTEM
PSYCHOANALEPTICS
PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
Centrally acting sympathomimetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D000697 Central Nervous System Stimulants
MeSH PA D065701 Cytochrome P-450 CYP3A Inducers
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
MeSH PA D064690 Wakefulness-Promoting Agents
FDA PE N0000175651 Increased Sympathetic Activity
FDA PE N0000175729 Central Nervous System Stimulation
FDA EPC N0000175769 Sympathomimetic-like Agent
CHEBI has role CHEBI:35337 analeptic
CHEBI has role CHEBI:77567 wakefulness-promoting agent

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Narcolepsy indication 60380001 DOID:8986
Hypersomnia indication 77692006
Sleepiness Due To Obstructive Sleep Apnea indication
Sleepiness Due To Shift Work Sleep Disorder indication
Suicidal thoughts contraindication 6471006
Alcoholism contraindication 7200002
Myocardial infarction contraindication 22298006 DOID:5844
Depressive disorder contraindication 35489007
Hypertensive disorder contraindication 38341003 DOID:10763
Left ventricular hypertrophy contraindication 55827005
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Aggressive behavior contraindication 61372001
Psychotic disorder contraindication 69322001
Mania contraindication 231494001
Acute coronary syndrome contraindication 394659003
Mitral valve prolapse contraindication 409712001
Myocardial ischemia contraindication 414795007 DOID:3393




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.23 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent dopamine transporter Transporter INHIBITOR Ki 5.84 DRUG MATRIX CHEMBL
D(3) dopamine receptor GPCR Ki 4.41 CHEMBL
Alpha-1B adrenergic receptor GPCR WOMBAT-PK
Cytochrome P450 1A2 Enzyme Ki 4.40 WOMBAT-PK
Cytochrome P450 2C19 Enzyme WOMBAT-PK
D(2) dopamine receptor GPCR EC50 6.62 WOMBAT-PK
Sodium-dependent serotonin transporter Transporter Ki 4.50 CHEMBL
Sodium-dependent dopamine transporter Transporter Ki 5.60 CHEMBL
Transporter Transporter IC50 4.19 CHEMBL

External reference:

IDSource
4021149 VUID
N0000148602 NUI
D01832 KEGG_DRUG
4021149 VANDF
C0066677 UMLSCUI
CHEBI:31859 CHEBI
CHEMBL1373 ChEMBL_ID
DB00745 DRUGBANK_ID
D000077408 MESH_DESCRIPTOR_UI
4236 PUBCHEM_CID
7555 IUPHAR_LIGAND_ID
6055 INN_ID
R3UK8X3U3D UNII
30125 RXNORM
52652 MMSL
7873 MMSL
d04378 MMSL
005305 NDDF
116082007 SNOMEDCT_US
387004007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Modafinil HUMAN PRESCRIPTION DRUG LABEL 1 0904-6423 TABLET 100 mg ORAL ANDA 29 sections
Modafinil HUMAN PRESCRIPTION DRUG LABEL 1 0904-6424 TABLET 200 mg ORAL ANDA 29 sections
Modafinil HUMAN PRESCRIPTION DRUG LABEL 1 0904-6791 TABLET 100 mg ORAL ANDA 19 sections
Modafinil HUMAN PRESCRIPTION DRUG LABEL 1 0904-6791 TABLET 100 mg ORAL ANDA 19 sections
Modafinil HUMAN PRESCRIPTION DRUG LABEL 1 0904-6792 TABLET 200 mg ORAL ANDA 19 sections
Modafinil HUMAN PRESCRIPTION DRUG LABEL 1 0904-6792 TABLET 200 mg ORAL ANDA 19 sections
PROVIGIL HUMAN PRESCRIPTION DRUG LABEL 1 21695-234 TABLET 100 mg ORAL NDA 25 sections
PROVIGIL HUMAN PRESCRIPTION DRUG LABEL 1 21695-235 TABLET 200 mg ORAL NDA 25 sections
Modafinil Human Prescription Drug Label 1 23155-604 TABLET 100 mg ORAL ANDA 24 sections
Modafinil Human Prescription Drug Label 1 23155-605 TABLET 200 mg ORAL ANDA 24 sections
Modafinil HUMAN PRESCRIPTION DRUG LABEL 1 42043-160 TABLET 100 mg ORAL ANDA 29 sections
Modafinil HUMAN PRESCRIPTION DRUG LABEL 1 42043-161 TABLET 200 mg ORAL ANDA 29 sections
Modafinil HUMAN PRESCRIPTION DRUG LABEL 1 42291-599 TABLET 100 mg ORAL ANDA 30 sections
Modafinil HUMAN PRESCRIPTION DRUG LABEL 1 42291-600 TABLET 200 mg ORAL ANDA 30 sections
MODAFINIL HUMAN PRESCRIPTION DRUG LABEL 1 42549-678 TABLET 200 mg ORAL NDA authorized generic 25 sections
Modafinil HUMAN PRESCRIPTION DRUG LABEL 1 43353-831 TABLET 200 mg ORAL ANDA 28 sections
modafinil HUMAN PRESCRIPTION DRUG LABEL 1 43353-925 TABLET 200 mg ORAL NDA authorized generic 25 sections
Modafinil HUMAN PRESCRIPTION DRUG LABEL 1 43353-956 TABLET 200 mg ORAL NDA authorized generic 28 sections
Modafinil Human Prescription Drug Label 1 46708-385 TABLET 100 mg ORAL ANDA 29 sections
Modafinil Human Prescription Drug Label 1 46708-386 TABLET 200 mg ORAL ANDA 29 sections
Modafinil Human Prescription Drug Label 1 50090-2472 TABLET 100 mg ORAL ANDA 29 sections
Modafinil Human Prescription Drug Label 1 50090-2473 TABLET 200 mg ORAL ANDA 29 sections
Modafinil HUMAN PRESCRIPTION DRUG LABEL 1 50090-3865 TABLET 100 mg ORAL ANDA 29 sections
Modafinil HUMAN PRESCRIPTION DRUG LABEL 1 50090-4144 TABLET 200 mg ORAL ANDA 19 sections
Modafinil HUMAN PRESCRIPTION DRUG LABEL 1 50268-570 TABLET 100 mg ORAL ANDA 29 sections
Modafinil HUMAN PRESCRIPTION DRUG LABEL 1 50268-570 TABLET 100 mg ORAL ANDA 29 sections
Modafinil HUMAN PRESCRIPTION DRUG LABEL 1 50268-571 TABLET 200 mg ORAL ANDA 29 sections
Modafinil HUMAN PRESCRIPTION DRUG LABEL 1 50268-571 TABLET 200 mg ORAL ANDA 29 sections
Provigil HUMAN PRESCRIPTION DRUG LABEL 1 50436-0201 TABLET 200 mg ORAL NDA 29 sections
PROVIGIL HUMAN PRESCRIPTION DRUG LABEL 1 54868-4492 TABLET 100 mg ORAL NDA 25 sections