mivacurium Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
neuromuscular blocking agents with rigid structure 1822 133814-19-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mivacurium
  • mivacurium chloride
An isoquinoline derivative that is used as a short-acting non-depolarizing agent.
  • Molecular weight: 1029.28
  • Formula: C58H80N2O14
  • CLOGP: 2.64
  • LIPINSKI: 2
  • HAC: 16
  • HDO: 0
  • TPSA: 144.90
  • ALOGS: -7.53
  • ROTB: 30

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.23 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 0 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.27 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 5.20 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.70 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.83 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 22, 1992 FDA ABBVIE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC M03AC10 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS
Other quaternary ammonium compounds
MeSH PA D009465 Neuromuscular Agents
MeSH PA D009466 Neuromuscular Blocking Agents
MeSH PA D003473 Neuromuscular Nondepolarizing Agents
MeSH PA D018373 Peripheral Nervous System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Muscle relaxation, function indication 11977004
General anesthesia indication 50697003
Skeletal Muscle Relaxation for Endotracheal Intubation indication
End stage renal disease contraindication 46177005 DOID:784
Burn injury contraindication 48333001
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Acute nephropathy contraindication 58574008
Myasthenia gravis contraindication 91637004 DOID:437
Disease of liver contraindication 235856003 DOID:409
Carcinomatosis contraindication 307593001
Deficiency of cholinesterase contraindication 360607009

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Acetylcholine receptor Ion channel ANTAGONIST WOMBAT-PK CHEMBL
Neuronal acetylcholine receptor subunit alpha-2 Ion channel WOMBAT-PK

External reference:

IDSource
D000077590 MESH_DESCRIPTOR_UI
4020541 VUID
N0000179194 NUI
C0066621 UMLSCUI
D00763 KEGG_DRUG
600ZG213C3 UNII
6226 INN_ID
106861-44-3 SECONDARY_CAS_RN
108446009 SNOMEDCT_US
4020541 VANDF
d00951 MMSL
30077 RXNORM
372493004 SNOMEDCT_US
013417 NDDF
CHEMBL984 ChEMBL_ID
CHEMBL1182833 ChEMBL_ID
DB01226 DRUGBANK_ID
CHEBI:6958 CHEBI
5281042 PUBCHEM_CID
7243 IUPHAR_LIGAND_ID

Pharmaceutical products:

None