mitiglinide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antihyperglycaemics 1818 145375-43-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mitiglinide
  • mitiglinide calcium
  • mitiglinide calcium hydrate
  • S 21403
  • KAD-1229
a rapid and short-acting hypoglycemic agent; acts on sulfonylurea receptor closing KATP channels; considered one of the glinides-an imprecise grouping; structure given in first source
  • Molecular weight: 315.41
  • Formula: C19H25NO3
  • CLOGP: 3.06
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 57.61
  • ALOGS: -3.65
  • ROTB: 5

Drug dosage:

DoseUnitRoute
30 mg O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
April 22, 2011 PMDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Enterocolitis haemorrhagic 44.93 44.74 8 321 1532 46684201

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Altered state of consciousness 47.07 31.44 18 740 19901 29931819
Renal impairment 34.14 31.44 23 735 84161 29867559
Hypoglycaemia 33.60 31.44 19 739 50962 29900758

Pharmacologic Action:

SourceCodeDescription
ATC A10BX08 ALIMENTARY TRACT AND METABOLISM
DRUGS USED IN DIABETES
BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Other blood glucose lowering drugs, excl. insulins
MeSH PA D007004 Hypoglycemic Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Diabetes mellitus type 2 indication 44054006 DOID:9352

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.91 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sulfonylurea receptor 1, Kir6.2 Ion channel BLOCKER IC50 7 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
D01854 KEGG_DRUG
C0254772 UMLSCUI
CHEBI:135349 CHEBI
CHEMBL4298005 ChEMBL_ID
CHEMBL471498 ChEMBL_ID
DB01252 DRUGBANK_ID
C087255 MESH_SUPPLEMENTAL_RECORD_UI
7710 INN_ID
D86I0XLB13 UNII
121891 PUBCHEM_CID

Pharmaceutical products:

None