Stem definition | Drug id | CAS RN |
---|---|---|
prostaglandins | 1817 | 59122-46-2 |
Dose | Unit | Route |
---|---|---|
0.80 | mg | O |
0.20 | mg | O |
0.20 | mg | V |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 0.50 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.03 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 80 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 27, 1988 | FDA | GD SEARLE LLC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Abortion incomplete | 8675.84 | 14.39 | 1433 | 19340 | 1693 | 50582658 |
Haemorrhage | 4482.99 | 14.39 | 1399 | 19374 | 52042 | 50532309 |
Pregnancy | 1570.34 | 14.39 | 551 | 20222 | 29026 | 50555325 |
Endometritis | 908.52 | 14.39 | 178 | 20595 | 797 | 50583554 |
Heavy menstrual bleeding | 642.01 | 14.39 | 241 | 20532 | 15296 | 50569055 |
Anaemia | 502.05 | 14.39 | 565 | 20208 | 251891 | 50332460 |
Muscle spasms | 364.55 | 14.39 | 345 | 20428 | 125208 | 50459143 |
Induced abortion failed | 275.23 | 14.39 | 52 | 20721 | 183 | 50584168 |
Exposure during pregnancy | 229.47 | 14.39 | 265 | 20508 | 120750 | 50463601 |
Drug ineffective for unapproved indication | 222.02 | 14.39 | 127 | 20646 | 21154 | 50563197 |
Uterine rupture | 191.75 | 14.39 | 51 | 20722 | 1024 | 50583327 |
Retained products of conception | 181.00 | 14.39 | 33 | 20740 | 90 | 50584261 |
Ectopic pregnancy | 152.88 | 14.39 | 51 | 20722 | 2276 | 50582075 |
Ruptured ectopic pregnancy | 145.70 | 14.39 | 34 | 20739 | 388 | 50583963 |
Pelvic inflammatory disease | 143.87 | 14.39 | 44 | 20729 | 1478 | 50582873 |
Vaginal haemorrhage | 137.46 | 14.39 | 99 | 20674 | 24452 | 50559899 |
Intermenstrual bleeding | 126.82 | 14.39 | 60 | 20713 | 6754 | 50577597 |
Pelvic pain | 114.45 | 14.39 | 66 | 20707 | 11147 | 50573204 |
Syncope | 110.62 | 14.39 | 171 | 20602 | 102831 | 50481520 |
Abdominal pain | 99.07 | 14.39 | 265 | 20508 | 235963 | 50348388 |
Uterine haemorrhage | 98.85 | 14.39 | 41 | 20732 | 3374 | 50580977 |
Abortion induced incomplete | 92.63 | 14.39 | 15 | 20758 | 13 | 50584338 |
Post abortion infection | 83.46 | 14.39 | 13 | 20760 | 6 | 50584345 |
Foetal exposure during pregnancy | 82.57 | 14.39 | 77 | 20696 | 27282 | 50557069 |
Pyrexia | 73.15 | 14.39 | 329 | 20444 | 379874 | 50204477 |
Foetal death | 72.61 | 14.39 | 44 | 20729 | 8136 | 50576215 |
Postpartum haemorrhage | 71.59 | 14.39 | 27 | 20746 | 1727 | 50582624 |
Haemorrhage in pregnancy | 68.64 | 14.39 | 26 | 20747 | 1683 | 50582668 |
Pain | 68.45 | 14.39 | 438 | 20335 | 578465 | 50005886 |
Fatigue | 65.99 | 14.39 | 119 | 20654 | 707482 | 49876869 |
Stillbirth | 63.32 | 14.39 | 36 | 20737 | 5916 | 50578435 |
Gestational diabetes | 63.30 | 14.39 | 39 | 20734 | 7426 | 50576925 |
Small for dates baby | 62.58 | 14.39 | 30 | 20743 | 3475 | 50580876 |
Complication of device insertion | 60.16 | 14.39 | 35 | 20738 | 6006 | 50578345 |
Dizziness | 57.98 | 14.39 | 288 | 20485 | 346081 | 50238270 |
Foetal methotrexate syndrome | 57.44 | 14.39 | 12 | 20761 | 78 | 50584273 |
Maternal exposure during pregnancy | 55.86 | 14.39 | 168 | 20605 | 159610 | 50424741 |
Arteriospasm coronary | 54.38 | 14.39 | 27 | 20746 | 3375 | 50580976 |
Peripheral swelling | 53.32 | 14.39 | 10 | 20763 | 205926 | 50378425 |
Product use in unapproved indication | 51.54 | 14.39 | 133 | 20640 | 115686 | 50468665 |
Uterine perforation | 48.09 | 14.39 | 31 | 20742 | 6384 | 50577967 |
Post abortion complication | 47.48 | 14.39 | 8 | 20765 | 11 | 50584340 |
Vaginal odour | 47.00 | 14.39 | 14 | 20759 | 429 | 50583922 |
Maternal exposure during delivery | 46.62 | 14.39 | 17 | 20756 | 989 | 50583362 |
Wrist deformity | 46.62 | 14.39 | 20 | 20753 | 1789 | 50582562 |
Chills | 46.11 | 14.39 | 114 | 20659 | 96573 | 50487778 |
Uterine tenderness | 45.28 | 14.39 | 8 | 20765 | 17 | 50584334 |
Death | 39.80 | 14.39 | 45 | 20728 | 325334 | 50259017 |
Uterine hypotonus | 38.87 | 14.39 | 9 | 20764 | 99 | 50584252 |
Pelvic infection | 38.72 | 14.39 | 11 | 20762 | 284 | 50584067 |
Procedural pain | 38.05 | 14.39 | 37 | 20736 | 13795 | 50570556 |
Embedded device | 38.04 | 14.39 | 20 | 20753 | 2817 | 50581534 |
Uterine tachysystole | 37.41 | 14.39 | 7 | 20766 | 23 | 50584328 |
Induced abortion haemorrhage | 36.64 | 14.39 | 6 | 20767 | 6 | 50584345 |
Systemic lupus erythematosus | 36.02 | 14.39 | 7 | 20766 | 140615 | 50443736 |
Microcephaly | 34.90 | 14.39 | 13 | 20760 | 803 | 50583548 |
Uterine atony | 33.72 | 14.39 | 9 | 20764 | 183 | 50584168 |
Product dose omission issue | 33.21 | 14.39 | 17 | 20756 | 183821 | 50400530 |
Toxic shock syndrome | 33.18 | 14.39 | 11 | 20762 | 481 | 50583870 |
Cerebral ventricle dilatation | 33.15 | 14.39 | 13 | 20760 | 924 | 50583427 |
Uterine hyperstimulation | 32.69 | 14.39 | 7 | 20766 | 52 | 50584299 |
Therapeutic product effect decreased | 32.36 | 14.39 | 8 | 20765 | 136042 | 50448309 |
Sinusitis | 31.98 | 14.39 | 15 | 20758 | 170543 | 50413808 |
Dysmorphism | 31.13 | 14.39 | 16 | 20757 | 2151 | 50582200 |
Off label use | 30.13 | 14.39 | 312 | 20461 | 474114 | 50110237 |
Toxicity to various agents | 29.85 | 14.39 | 26 | 20747 | 212473 | 50371878 |
Alopecia | 29.82 | 14.39 | 34 | 20739 | 245013 | 50339338 |
Respiratory disorder neonatal | 29.62 | 14.39 | 12 | 20761 | 929 | 50583422 |
Abortion induced | 29.54 | 14.39 | 27 | 20746 | 9317 | 50575034 |
Febrile neutropenia | 29.35 | 14.39 | 3 | 20770 | 97664 | 50486687 |
Drug ineffective | 29.27 | 14.39 | 207 | 20566 | 819126 | 49765225 |
Post procedural discomfort | 29.15 | 14.39 | 12 | 20761 | 968 | 50583383 |
Joint swelling | 28.81 | 14.39 | 35 | 20738 | 245251 | 50339100 |
Adactyly | 28.21 | 14.39 | 6 | 20767 | 43 | 50584308 |
Abnormal palmar/plantar creases | 28.09 | 14.39 | 6 | 20767 | 44 | 50584307 |
Congenital multiplex arthrogryposis | 27.88 | 14.39 | 5 | 20768 | 12 | 50584339 |
Oral fibroma | 27.10 | 14.39 | 6 | 20767 | 53 | 50584298 |
Uterine dilation and curettage | 27.04 | 14.39 | 11 | 20762 | 861 | 50583490 |
Neutropenia | 26.25 | 14.39 | 14 | 20759 | 147951 | 50436400 |
Abortion | 25.74 | 14.39 | 14 | 20759 | 2110 | 50582241 |
Completed suicide | 25.65 | 14.39 | 11 | 20762 | 131878 | 50452473 |
Abortion infected | 25.57 | 14.39 | 5 | 20768 | 22 | 50584329 |
Arnold-Chiari malformation | 25.39 | 14.39 | 9 | 20764 | 482 | 50583869 |
Craniosynostosis | 25.29 | 14.39 | 7 | 20766 | 164 | 50584187 |
Endometritis bacterial | 24.96 | 14.39 | 4 | 20769 | 3 | 50584348 |
Pre-eclampsia | 24.95 | 14.39 | 23 | 20750 | 8021 | 50576330 |
Bloody discharge | 23.89 | 14.39 | 11 | 20762 | 1163 | 50583188 |
Lower respiratory tract infection | 23.83 | 14.39 | 5 | 20768 | 95196 | 50489155 |
Acute kidney injury | 23.29 | 14.39 | 36 | 20737 | 228022 | 50356329 |
Product complaint | 23.15 | 14.39 | 26 | 20747 | 11440 | 50572911 |
Meconium in amniotic fluid | 22.66 | 14.39 | 7 | 20766 | 243 | 50584108 |
Uterine hypertonus | 22.53 | 14.39 | 7 | 20766 | 248 | 50584103 |
Contraindicated product administered | 22.43 | 14.39 | 17 | 20756 | 148941 | 50435410 |
Vaginal discharge | 22.40 | 14.39 | 18 | 20755 | 5222 | 50579129 |
Confusional state | 22.39 | 14.39 | 26 | 20747 | 185902 | 50398449 |
Infusion related reaction | 22.32 | 14.39 | 22 | 20751 | 169535 | 50414816 |
Abdominal discomfort | 22.31 | 14.39 | 38 | 20735 | 231603 | 50352748 |
Diarrhoea | 22.27 | 14.39 | 146 | 20627 | 588330 | 49996021 |
Post abortion haemorrhage | 22.02 | 14.39 | 5 | 20768 | 50 | 50584301 |
Injection site pain | 22.01 | 14.39 | 9 | 20764 | 111015 | 50473336 |
Intentional product use issue | 21.53 | 14.39 | 3 | 20770 | 76915 | 50507436 |
Infantile haemangioma | 21.43 | 14.39 | 5 | 20768 | 57 | 50584294 |
Congenital joint malformation | 21.41 | 14.39 | 4 | 20769 | 13 | 50584338 |
Victim of homicide | 21.19 | 14.39 | 5 | 20768 | 60 | 50584291 |
Maternal exposure timing unspecified | 21.17 | 14.39 | 15 | 20758 | 3605 | 50580746 |
Fall | 21.03 | 14.39 | 69 | 20704 | 334863 | 50249488 |
Arthralgia | 20.83 | 14.39 | 101 | 20672 | 438601 | 50145750 |
Maternal drugs affecting foetus | 20.77 | 14.39 | 17 | 20756 | 5060 | 50579291 |
Microgenia | 20.76 | 14.39 | 4 | 20769 | 16 | 50584335 |
Dyspnoea | 20.64 | 14.39 | 136 | 20637 | 547472 | 50036879 |
Weight increased | 20.49 | 14.39 | 32 | 20741 | 201859 | 50382492 |
Glossodynia | 20.40 | 14.39 | 11 | 20762 | 115558 | 50468793 |
Hyponatraemia | 20.38 | 14.39 | 7 | 20766 | 96132 | 50488219 |
Tongue oedema | 20.38 | 14.39 | 15 | 20758 | 3824 | 50580527 |
Treatment failure | 20.35 | 14.39 | 16 | 20757 | 137621 | 50446730 |
Hepatic enzyme increased | 20.28 | 14.39 | 16 | 20757 | 137364 | 50446987 |
Arthropathy | 20.20 | 14.39 | 21 | 20752 | 157885 | 50426466 |
Discomfort | 19.59 | 14.39 | 10 | 20763 | 108370 | 50475981 |
Pruritus | 19.52 | 14.39 | 56 | 20717 | 283512 | 50300839 |
Foetal heart rate disorder | 19.41 | 14.39 | 5 | 20768 | 88 | 50584263 |
Device difficult to use | 19.25 | 14.39 | 22 | 20751 | 9864 | 50574487 |
Nasopharyngitis | 19.18 | 14.39 | 31 | 20742 | 192896 | 50391455 |
Spina bifida | 18.93 | 14.39 | 8 | 20765 | 689 | 50583662 |
Rash | 18.91 | 14.39 | 104 | 20669 | 437367 | 50146984 |
Micrognathia | 18.73 | 14.39 | 6 | 20767 | 235 | 50584116 |
Polyhydramnios | 18.24 | 14.39 | 11 | 20762 | 2014 | 50582337 |
Tachycardia | 18.07 | 14.39 | 85 | 20688 | 99678 | 50484673 |
Low set ears | 18.06 | 14.39 | 6 | 20767 | 264 | 50584087 |
Uterine spasm | 18.05 | 14.39 | 7 | 20766 | 483 | 50583868 |
Uterine disorder | 17.88 | 14.39 | 12 | 20761 | 2643 | 50581708 |
Gross motor delay | 17.79 | 14.39 | 5 | 20768 | 124 | 50584227 |
Retained placenta or membranes | 17.66 | 14.39 | 6 | 20767 | 283 | 50584068 |
Drug intolerance | 17.59 | 14.39 | 40 | 20733 | 219064 | 50365287 |
International normalised ratio fluctuation | 17.45 | 14.39 | 11 | 20762 | 2179 | 50582172 |
Premature separation of placenta | 17.45 | 14.39 | 10 | 20763 | 1668 | 50582683 |
Pregnancy with contraceptive device | 17.41 | 14.39 | 14 | 20759 | 4065 | 50580286 |
Anaphylactoid syndrome of pregnancy | 17.27 | 14.39 | 4 | 20769 | 44 | 50584307 |
Cough | 17.07 | 14.39 | 47 | 20726 | 241217 | 50343134 |
General physical health deterioration | 17.05 | 14.39 | 20 | 20753 | 142414 | 50441937 |
Foetal exposure during delivery | 17.03 | 14.39 | 4 | 20769 | 47 | 50584304 |
Headache | 17.02 | 14.39 | 130 | 20643 | 506405 | 50077946 |
Congenital choroid plexus cyst | 16.97 | 14.39 | 6 | 20767 | 319 | 50584032 |
Microphthalmos | 16.92 | 14.39 | 5 | 20768 | 149 | 50584202 |
Vomiting | 16.87 | 14.39 | 274 | 20499 | 460484 | 50123867 |
Abortion complete | 16.79 | 14.39 | 3 | 20770 | 7 | 50584344 |
Third stage postpartum haemorrhage | 16.79 | 14.39 | 3 | 20770 | 7 | 50584344 |
Synostosis | 16.32 | 14.39 | 4 | 20769 | 57 | 50584294 |
Pneumonia | 16.32 | 14.39 | 90 | 20683 | 378311 | 50206040 |
Thrombocytopenia | 16.30 | 14.39 | 17 | 20756 | 127656 | 50456695 |
Hospitalisation | 16.13 | 14.39 | 4 | 20769 | 67933 | 50516418 |
Congenital pneumonia | 16.00 | 14.39 | 3 | 20770 | 10 | 50584341 |
Stomatitis | 15.99 | 14.39 | 11 | 20762 | 101333 | 50483018 |
Lyme disease | 15.95 | 14.39 | 11 | 20762 | 2532 | 50581819 |
Limb reduction defect | 15.95 | 14.39 | 6 | 20767 | 381 | 50583970 |
Movement disorder | 15.79 | 14.39 | 27 | 20746 | 17605 | 50566746 |
Weight decreased | 15.73 | 14.39 | 43 | 20730 | 221202 | 50363149 |
Dysmenorrhoea | 15.50 | 14.39 | 12 | 20761 | 3298 | 50581053 |
Breast tenderness | 15.43 | 14.39 | 10 | 20763 | 2078 | 50582273 |
Amniotic cavity infection | 15.03 | 14.39 | 8 | 20765 | 1155 | 50583196 |
Uterine contractions abnormal | 15.03 | 14.39 | 5 | 20768 | 221 | 50584130 |
Premature baby | 15.02 | 14.39 | 27 | 20746 | 18310 | 50566041 |
Uterine cervix stenosis | 14.94 | 14.39 | 5 | 20768 | 225 | 50584126 |
Uterine cervical laceration | 14.71 | 14.39 | 3 | 20770 | 17 | 50584334 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Foetal exposure during pregnancy | 235.19 | 15.08 | 112 | 4561 | 33755 | 29536099 |
Maternal exposure during pregnancy | 85.64 | 15.08 | 30 | 4643 | 4093 | 29565761 |
Anencephaly | 70.02 | 15.08 | 13 | 4660 | 126 | 29569728 |
Premature baby | 52.07 | 15.08 | 33 | 4640 | 17247 | 29552607 |
Pulmonary hypoplasia | 50.28 | 15.08 | 12 | 4661 | 414 | 29569440 |
Congenital hydrocephalus | 48.59 | 15.08 | 9 | 4664 | 86 | 29569768 |
Poor weight gain neonatal | 46.26 | 15.08 | 7 | 4666 | 15 | 29569839 |
Congenital megaureter | 45.43 | 15.08 | 9 | 4664 | 126 | 29569728 |
Renal aplasia | 44.96 | 15.08 | 12 | 4661 | 654 | 29569200 |
Neonatal respiratory arrest | 44.09 | 15.08 | 7 | 4666 | 23 | 29569831 |
Micrognathia | 43.31 | 15.08 | 10 | 4663 | 298 | 29569556 |
Stillbirth | 42.95 | 15.08 | 9 | 4664 | 169 | 29569685 |
Meningocele | 42.26 | 15.08 | 7 | 4666 | 32 | 29569822 |
Congenital cystic kidney disease | 40.79 | 15.08 | 10 | 4663 | 387 | 29569467 |
Foetal growth restriction | 40.61 | 15.08 | 17 | 4656 | 3749 | 29566105 |
Moebius II syndrome | 38.77 | 15.08 | 5 | 4668 | 0 | 29569854 |
Respiratory disorder neonatal | 35.95 | 15.08 | 12 | 4661 | 1413 | 29568441 |
Congenital cystic lung | 35.20 | 15.08 | 8 | 4665 | 222 | 29569632 |
Newborn persistent pulmonary hypertension | 34.89 | 15.08 | 7 | 4666 | 105 | 29569749 |
Anomaly of external ear congenital | 34.89 | 15.08 | 7 | 4666 | 105 | 29569749 |
Intervertebral disc compression | 34.01 | 15.08 | 8 | 4665 | 259 | 29569595 |
Heart disease congenital | 33.17 | 15.08 | 11 | 4662 | 1269 | 29568585 |
Cleft lip and palate | 32.50 | 15.08 | 8 | 4665 | 315 | 29569539 |
External auditory canal atresia | 31.42 | 15.08 | 7 | 4666 | 177 | 29569677 |
Genitalia external ambiguous | 30.40 | 15.08 | 7 | 4666 | 206 | 29569648 |
Haemangioma congenital | 29.04 | 15.08 | 8 | 4665 | 491 | 29569363 |
Congenital diaphragmatic hernia | 28.75 | 15.08 | 7 | 4666 | 263 | 29569591 |
Retroperitoneal fibrosis | 28.11 | 15.08 | 7 | 4666 | 289 | 29569565 |
Maternal drugs affecting foetus | 27.29 | 15.08 | 13 | 4660 | 3880 | 29565974 |
Paternal exposure before pregnancy | 26.97 | 15.08 | 5 | 4668 | 48 | 29569806 |
Interstitial lung disease | 26.89 | 15.08 | 39 | 4634 | 57679 | 29512175 |
Patent ductus arteriosus | 26.77 | 15.08 | 12 | 4661 | 3119 | 29566735 |
Congenital pulmonary valve atresia | 26.35 | 15.08 | 5 | 4668 | 55 | 29569799 |
Congenital tricuspid valve atresia | 23.20 | 15.08 | 5 | 4668 | 108 | 29569746 |
Double outlet right ventricle | 23.15 | 15.08 | 5 | 4668 | 109 | 29569745 |
Talipes | 22.42 | 15.08 | 9 | 4664 | 1783 | 29568071 |
Kidney duplex | 21.27 | 15.08 | 6 | 4667 | 402 | 29569452 |
Atrial septal defect | 20.52 | 15.08 | 13 | 4660 | 6776 | 29563078 |
Arachnoid cyst | 20.18 | 15.08 | 5 | 4668 | 202 | 29569652 |
Gastric ulcer haemorrhage | 18.95 | 15.08 | 11 | 4662 | 4903 | 29564951 |
Cerebellar hypoplasia | 18.64 | 15.08 | 3 | 4670 | 11 | 29569843 |
Craniofacial deformity | 18.49 | 15.08 | 4 | 4669 | 88 | 29569766 |
Hyperbilirubinaemia neonatal | 17.73 | 15.08 | 6 | 4667 | 736 | 29569118 |
Spinal deformity | 16.72 | 15.08 | 5 | 4668 | 412 | 29569442 |
Low set ears | 16.48 | 15.08 | 5 | 4668 | 432 | 29569422 |
Death | 16.40 | 15.08 | 18 | 4655 | 342066 | 29227788 |
Vesicoureteric reflux | 16.36 | 15.08 | 4 | 4669 | 153 | 29569701 |
Congenital central nervous system anomaly | 16.29 | 15.08 | 5 | 4668 | 450 | 29569404 |
Congenital bowing of long bones | 16.26 | 15.08 | 3 | 4670 | 28 | 29569826 |
Foetal distress syndrome | 15.99 | 15.08 | 6 | 4667 | 993 | 29568861 |
Neonatal respiratory distress syndrome | 15.95 | 15.08 | 9 | 4664 | 3801 | 29566053 |
Congenital nose malformation | 15.36 | 15.08 | 4 | 4669 | 198 | 29569656 |
Delayed fontanelle closure | 15.35 | 15.08 | 3 | 4670 | 39 | 29569815 |
Hypertelorism | 15.27 | 15.08 | 5 | 4668 | 554 | 29569300 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Abortion incomplete | 8969.85 | 14.49 | 1422 | 19388 | 1639 | 64476283 |
Haemorrhage | 4221.42 | 14.49 | 1387 | 19423 | 77964 | 64399958 |
Pregnancy | 1845.78 | 14.49 | 541 | 20269 | 20324 | 64457598 |
Endometritis | 954.75 | 14.49 | 172 | 20638 | 594 | 64477328 |
Heavy menstrual bleeding | 733.57 | 14.49 | 235 | 20575 | 11842 | 64466080 |
Anaemia | 430.27 | 14.49 | 567 | 20243 | 378113 | 64099809 |
Muscle spasms | 391.42 | 14.49 | 340 | 20470 | 140683 | 64337239 |
Exposure during pregnancy | 281.71 | 14.49 | 219 | 20591 | 77456 | 64400466 |
Induced abortion failed | 219.12 | 14.49 | 40 | 20770 | 151 | 64477771 |
Retained products of conception | 190.30 | 14.49 | 33 | 20777 | 85 | 64477837 |
Uterine rupture | 187.44 | 14.49 | 44 | 20766 | 669 | 64477253 |
Ectopic pregnancy | 184.97 | 14.49 | 51 | 20759 | 1513 | 64476409 |
Pelvic inflammatory disease | 162.63 | 14.49 | 44 | 20766 | 1214 | 64476708 |
Vaginal haemorrhage | 143.37 | 14.49 | 85 | 20725 | 19259 | 64458663 |
Ruptured ectopic pregnancy | 140.34 | 14.49 | 31 | 20779 | 353 | 64477569 |
Pain | 136.09 | 14.49 | 439 | 20371 | 553072 | 63924850 |
Pelvic pain | 131.07 | 14.49 | 66 | 20744 | 10844 | 64467078 |
Intermenstrual bleeding | 125.59 | 14.49 | 51 | 20759 | 5074 | 64472848 |
Drug ineffective for unapproved indication | 117.55 | 14.49 | 90 | 20720 | 31043 | 64446879 |
Uterine haemorrhage | 104.27 | 14.49 | 37 | 20773 | 2542 | 64475380 |
Maternal exposure during pregnancy | 99.57 | 14.49 | 138 | 20672 | 95746 | 64382176 |
Syncope | 90.01 | 14.49 | 173 | 20637 | 157462 | 64320460 |
Abdominal pain | 84.01 | 14.49 | 256 | 20554 | 312119 | 64165803 |
Abortion induced incomplete | 83.55 | 14.49 | 13 | 20797 | 11 | 64477911 |
Haemorrhage in pregnancy | 82.13 | 14.49 | 26 | 20784 | 1254 | 64476668 |
Foetal death | 80.52 | 14.49 | 39 | 20771 | 5891 | 64472031 |
Post abortion infection | 79.61 | 14.49 | 12 | 20798 | 6 | 64477916 |
Complication of device insertion | 71.20 | 14.49 | 34 | 20776 | 4978 | 64472944 |
Postpartum haemorrhage | 71.04 | 14.49 | 24 | 20786 | 1423 | 64476499 |
Gestational diabetes | 70.63 | 14.49 | 35 | 20775 | 5555 | 64472367 |
Dizziness | 63.05 | 14.49 | 290 | 20520 | 429873 | 64048049 |
Stillbirth | 58.89 | 14.49 | 27 | 20783 | 3606 | 64474316 |
Uterine perforation | 57.82 | 14.49 | 31 | 20779 | 5789 | 64472133 |
Vaginal odour | 54.54 | 14.49 | 14 | 20796 | 313 | 64477609 |
Uterine tenderness | 54.53 | 14.49 | 9 | 20801 | 15 | 64477907 |
Maternal exposure during delivery | 52.67 | 14.49 | 17 | 20793 | 873 | 64477049 |
Wrist deformity | 51.37 | 14.49 | 20 | 20790 | 1780 | 64476142 |
Pyrexia | 49.15 | 14.49 | 328 | 20482 | 558316 | 63919606 |
Death | 48.07 | 14.49 | 51 | 20759 | 482654 | 63995268 |
Arteriospasm coronary | 45.74 | 14.49 | 26 | 20784 | 5439 | 64472483 |
Uterine hypotonus | 43.28 | 14.49 | 9 | 20801 | 75 | 64477847 |
Embedded device | 43.19 | 14.49 | 20 | 20790 | 2732 | 64475190 |
Completed suicide | 42.70 | 14.49 | 10 | 20800 | 224404 | 64253518 |
Toxicity to various agents | 42.61 | 14.49 | 33 | 20777 | 363480 | 64114442 |
Uterine tachysystole | 42.29 | 14.49 | 7 | 20803 | 12 | 64477910 |
Procedural pain | 42.06 | 14.49 | 37 | 20773 | 15471 | 64462451 |
Fatigue | 40.86 | 14.49 | 116 | 20694 | 748614 | 63729308 |
Peripheral swelling | 40.43 | 14.49 | 9 | 20801 | 209144 | 64268778 |
Acute kidney injury | 39.85 | 14.49 | 52 | 20758 | 449188 | 64028734 |
Post abortion complication | 38.60 | 14.49 | 6 | 20804 | 5 | 64477917 |
Induced abortion haemorrhage | 38.08 | 14.49 | 6 | 20804 | 6 | 64477916 |
Uterine dilation and curettage | 35.81 | 14.49 | 11 | 20799 | 480 | 64477442 |
Abortion induced | 34.55 | 14.49 | 23 | 20787 | 6365 | 64471557 |
Febrile neutropenia | 34.45 | 14.49 | 9 | 20801 | 187648 | 64290274 |
Post procedural discomfort | 32.91 | 14.49 | 12 | 20798 | 891 | 64477031 |
Pre-eclampsia | 32.66 | 14.49 | 22 | 20788 | 6209 | 64471713 |
Endometritis bacterial | 32.26 | 14.49 | 5 | 20805 | 4 | 64477918 |
Chills | 31.77 | 14.49 | 107 | 20703 | 137157 | 64340765 |
Uterine atony | 31.69 | 14.49 | 8 | 20802 | 167 | 64477755 |
Vaginal discharge | 30.75 | 14.49 | 18 | 20792 | 3979 | 64473943 |
Toxic shock syndrome | 29.44 | 14.49 | 11 | 20799 | 875 | 64477047 |
Abortion infected | 28.03 | 14.49 | 5 | 20805 | 16 | 64477906 |
Product dose omission issue | 27.87 | 14.49 | 14 | 20796 | 194733 | 64283189 |
Dyspnoea | 26.32 | 14.49 | 131 | 20679 | 718543 | 63759379 |
Meconium in amniotic fluid | 26.15 | 14.49 | 6 | 20804 | 82 | 64477840 |
Maternal drugs affecting foetus | 26.13 | 14.49 | 12 | 20798 | 1608 | 64476314 |
Abortion | 25.89 | 14.49 | 11 | 20799 | 1225 | 64476697 |
Uterine hypertonus | 24.81 | 14.49 | 7 | 20803 | 226 | 64477696 |
Small for dates baby | 24.41 | 14.49 | 8 | 20802 | 431 | 64477491 |
Bloody discharge | 24.01 | 14.49 | 11 | 20799 | 1466 | 64476456 |
Device difficult to use | 23.85 | 14.49 | 22 | 20788 | 9776 | 64468146 |
Pregnancy with contraceptive device | 23.64 | 14.49 | 14 | 20796 | 3160 | 64474762 |
Product use in unapproved indication | 23.52 | 14.49 | 116 | 20694 | 176502 | 64301420 |
Pelvic infection | 22.77 | 14.49 | 7 | 20803 | 306 | 64477616 |
Therapeutic product effect decreased | 22.21 | 14.49 | 5 | 20805 | 115346 | 64362576 |
Neutropenia | 21.97 | 14.49 | 27 | 20783 | 239597 | 64238325 |
Uterine disorder | 21.84 | 14.49 | 11 | 20799 | 1806 | 64476116 |
Vomiting | 21.22 | 14.49 | 271 | 20539 | 550846 | 63927076 |
Polyhydramnios | 20.85 | 14.49 | 10 | 20800 | 1477 | 64476445 |
Hyponatraemia | 20.72 | 14.49 | 11 | 20799 | 148328 | 64329594 |
Retained placenta or membranes | 20.64 | 14.49 | 6 | 20804 | 216 | 64477706 |
Confusional state | 20.39 | 14.49 | 33 | 20777 | 261111 | 64216811 |
Maternal exposure timing unspecified | 20.32 | 14.49 | 12 | 20798 | 2695 | 64475227 |
Premature separation of placenta | 20.12 | 14.49 | 9 | 20801 | 1135 | 64476787 |
Injection site pain | 19.23 | 14.49 | 6 | 20804 | 111402 | 64366520 |
Uterine hyperstimulation | 19.16 | 14.49 | 4 | 20806 | 34 | 64477888 |
Joint swelling | 18.98 | 14.49 | 25 | 20785 | 215357 | 64262565 |
Lyme disease | 18.90 | 14.49 | 11 | 20799 | 2404 | 64475518 |
Anaphylactoid syndrome of pregnancy | 18.58 | 14.49 | 4 | 20806 | 40 | 64477882 |
Diarrhoea | 18.54 | 14.49 | 147 | 20663 | 722557 | 63755365 |
Post abortion haemorrhage | 17.91 | 14.49 | 4 | 20806 | 48 | 64477874 |
Breast tenderness | 17.83 | 14.49 | 10 | 20800 | 2039 | 64475883 |
Abortion complete | 17.82 | 14.49 | 3 | 20807 | 6 | 64477916 |
General physical health deterioration | 17.74 | 14.49 | 24 | 20786 | 204401 | 64273521 |
Hysterectomy | 17.66 | 14.49 | 14 | 20796 | 5071 | 64472851 |
Third stage postpartum haemorrhage | 17.51 | 14.49 | 3 | 20807 | 7 | 64477915 |
Victim of homicide | 17.42 | 14.49 | 5 | 20805 | 172 | 64477750 |
Uterine spasm | 17.30 | 14.49 | 6 | 20804 | 385 | 64477537 |
International normalised ratio fluctuation | 16.84 | 14.49 | 11 | 20799 | 2950 | 64474972 |
Product complaint | 16.78 | 14.49 | 20 | 20790 | 11934 | 64465988 |
Infusion related reaction | 16.74 | 14.49 | 17 | 20793 | 164450 | 64313472 |
Weight decreased | 16.46 | 14.49 | 43 | 20767 | 285696 | 64192226 |
Oligohydramnios | 16.30 | 14.49 | 11 | 20799 | 3113 | 64474809 |
Drug interaction | 16.26 | 14.49 | 61 | 20749 | 362022 | 64115900 |
Bacterial vulvovaginitis | 16.21 | 14.49 | 6 | 20804 | 465 | 64477457 |
Abnormal labour | 16.10 | 14.49 | 3 | 20807 | 13 | 64477909 |
Dysmenorrhoea | 16.00 | 14.49 | 10 | 20800 | 2487 | 64475435 |
Uterine infection | 15.88 | 14.49 | 5 | 20805 | 237 | 64477685 |
Tongue oedema | 15.66 | 14.49 | 14 | 20796 | 5976 | 64471946 |
Uterine cervical laceration | 15.43 | 14.49 | 3 | 20807 | 17 | 64477905 |
Gastrointestinal disorder | 15.18 | 14.49 | 5 | 20805 | 89704 | 64388218 |
Hospitalisation | 15.01 | 14.49 | 3 | 20807 | 75204 | 64402718 |
Lower respiratory tract infection | 14.78 | 14.49 | 6 | 20804 | 94608 | 64383314 |
Fall | 14.63 | 14.49 | 77 | 20733 | 416749 | 64061173 |
Genital haemorrhage | 14.62 | 14.49 | 13 | 20797 | 5509 | 64472413 |
None
Source | Code | Description |
---|---|---|
ATC | A02BB01 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR ACID RELATED DISORDERS DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD) Prostaglandins |
ATC | G02AD06 | GENITO URINARY SYSTEM AND SEX HORMONES OTHER GYNECOLOGICALS UTEROTONICS Prostaglandins |
ATC | M01AE56 | MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Propionic acid derivatives |
FDA CS | M0017811 | Prostaglandins E, Synthetic |
FDA EPC | N0000175785 | Prostaglandin E1 Analog |
CHEBI has role | CHEBI:36063 | oxytocic agents |
CHEBI has role | CHEBI:49201 | anti-ulcer drugs |
CHEBI has role | CHEBI:50691 | abortifacient drug |
MeSH PA | D000019 | Abortifacient Agents |
MeSH PA | D000020 | Abortifacient Agents, Nonsteroidal |
MeSH PA | D000897 | Anti-Ulcer Agents |
MeSH PA | D005765 | Gastrointestinal Agents |
MeSH PA | D010120 | Oxytocics |
MeSH PA | D012102 | Reproductive Control Agents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Postpartum hemorrhage | indication | 47821001 | |
Rheumatoid Arthritis in Patient at High Ulcer Risk | indication | ||
Prevention of NSAID-Induced Gastric Ulcer | indication | ||
Prevention of CMV Disease After Organ Transplant | indication | ||
Osteoarthritis in Patients at High Ulcer Risk | indication | ||
Ankylosing spondylitis | off-label use | 9631008 | DOID:7147 |
Peptic ulcer | off-label use | 13200003 | DOID:750 |
Duodenal ulcer disease | off-label use | 51868009 | DOID:1724 |
Cervical ripening procedure | off-label use | 236959001 | |
Pregnancy with abortive outcome | off-label use | 363681007 | |
Gastric ulcer | off-label use | 397825006 | DOID:10808 |
NSAID-Induced Gastric Ulcer | off-label use | ||
Alcoholism | contraindication | 7200002 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Inflammatory bowel disease | contraindication | 24526004 | DOID:0050589 |
Dehydration | contraindication | 34095006 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Gastrointestinal ulcer | contraindication | 40845000 | |
Body fluid retention | contraindication | 43498006 | |
Chronic heart failure | contraindication | 48447003 | |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Gastrointestinal perforation | contraindication | 51875005 | |
Acute nephropathy | contraindication | 58574008 | |
Hepatic failure | contraindication | 59927004 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Gastrointestinal hemorrhage | contraindication | 74474003 | |
Liver function tests abnormal | contraindication | 166603001 | |
Asthma | contraindication | 195967001 | DOID:2841 |
Deliveries by cesarean | contraindication | 200144004 | |
Non-infective meningitis | contraindication | 230155003 | |
Cerebrovascular accident | contraindication | 230690007 | |
Coronary artery bypass graft | contraindication | 232717009 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Drug-induced hepatitis | contraindication | 235876009 | |
Edema | contraindication | 267038008 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Pregnancy, function | contraindication | 289908002 | |
Cardiovascular event risk | contraindication | 395112001 | |
Smokes tobacco daily | contraindication | 449868002 | |
Uterine Rupture in Pregnancy | contraindication | ||
Bloody Vomit | contraindication | ||
Gynecological Surgery | contraindication |
None
None
None
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Prostaglandin E2 receptor EP3 subtype | GPCR | AGONIST | Ki | 8.10 | IUPHAR | CHEMBL | |||
Prostaglandin E2 receptor EP2 subtype | GPCR | AGONIST | Ki | 7.50 | IUPHAR | ||||
Prostaglandin E2 receptor EP4 subtype | GPCR | AGONIST | Ki | 7.60 | IUPHAR | ||||
Prostaglandin F2-alpha receptor | GPCR | Ki | 5.03 | PDSP |
ID | Source |
---|---|
4019313 | VUID |
N0000147506 | NUI |
D00419 | KEGG_DRUG |
4019313 | VANDF |
C0085174 | UMLSCUI |
CHEBI:63610 | CHEBI |
CHEMBL606 | ChEMBL_ID |
DB00929 | DRUGBANK_ID |
D016595 | MESH_DESCRIPTOR_UI |
5282381 | PUBCHEM_CID |
C047042 | MESH_SUPPLEMENTAL_RECORD_UI |
5154 | INN_ID |
66792-31-2 | SECONDARY_CAS_RN |
0E43V0BB57 | UNII |
6436406 | PUBCHEM_CID |
151578 | RXNORM |
44310 | MMSL |
445 | MMSL |
5121 | MMSL |
d00303 | MMSL |
001133 | NDDF |
387242007 | SNOMEDCT_US |
43684009 | SNOMEDCT_US |
C0377863 | UMLSCUI |
CHEMBL1201377 | ChEMBL_ID |
12Z0SU967A | UNII |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
ARTHROTEC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0025-1411 | TABLET, FILM COATED | 200 ug | ORAL | NDA | 30 sections |
ARTHROTEC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0025-1421 | TABLET, FILM COATED | 200 ug | ORAL | NDA | 30 sections |
Cytotec | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0025-1451 | TABLET | 100 ug | ORAL | NDA | 28 sections |
Cytotec | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0025-1461 | TABLET | 200 ug | ORAL | NDA | 28 sections |
Diclofenac Sodium and Misoprostol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0591-0397 | TABLET, DELAYED RELEASE | 200 ug | ORAL | ANDA | 28 sections |
Diclofenac Sodium and Misoprostol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0591-0398 | TABLET, DELAYED RELEASE | 200 ug | ORAL | ANDA | 28 sections |
Misoprostol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6806 | TABLET | 100 ug | ORAL | ANDA | 22 sections |
Misoprostol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6807 | TABLET | 200 ug | ORAL | ANDA | 22 sections |
Misoprostol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10135-745 | TABLET | 100 ug | ORAL | ANDA | 20 sections |
Misoprostol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10135-746 | TABLET | 200 ug | ORAL | ANDA | 20 sections |
Diclofenac Sodium and Misoprostol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 10544-949 | TABLET, DELAYED RELEASE | 200 ug | ORAL | ANDA | 24 sections |
Diclofenac Sodium and MisoprostolDelayed-Release | HUMAN PRESCRIPTION DRUG LABEL | 2 | 10544-955 | TABLET, DELAYED RELEASE | 0.20 mg | ORAL | ANDA | 30 sections |
misoprostol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12634-502 | TABLET | 200 ug | ORAL | NDA authorized generic | 27 sections |
CYTOTEC | HUMAN PRESCRIPTION DRUG LABEL | 1 | 12634-933 | TABLET | 200 ug | ORAL | NDA | 13 sections |
ARTHROTEC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 16590-024 | TABLET, FILM COATED | 200 ug | ORAL | NDA | 31 sections |
ARTHROTEC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 21695-425 | TABLET, FILM COATED | 200 ug | ORAL | NDA | 30 sections |
Misoprostol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-076 | TABLET | 200 ug | ORAL | ANDA | 15 sections |
Misoprostol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-754 | TABLET | 100 ug | ORAL | ANDA | 15 sections |
Misoprostol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 40032-160 | TABLET | 100 ug | ORAL | ANDA | 22 sections |
Misoprostol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 40032-161 | TABLET | 200 ug | ORAL | ANDA | 22 sections |
Diclofenac Sodium and Misoprostol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 42291-232 | TABLET, DELAYED RELEASE | 200 ug | ORAL | ANDA | 27 sections |
Diclofenac Sodium and Misoprostol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 42291-233 | TABLET, DELAYED RELEASE | 200 ug | ORAL | ANDA | 27 sections |
Diclofenac Sodium and Misoprostol Delayed-Release | HUMAN PRESCRIPTION DRUG LABEL | 2 | 42367-110 | TABLET, DELAYED RELEASE | 0.20 mg | ORAL | ANDA | 30 sections |
Diclofenac Sodium and Misoprostol Delayed-Release | HUMAN PRESCRIPTION DRUG LABEL | 2 | 42367-111 | TABLET, DELAYED RELEASE | 0.20 mg | ORAL | ANDA | 30 sections |
Diclofenac Sodium/Misoprostoldiclofenac-sodium-misoprostol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 42571-133 | TABLET | 200 ug | ORAL | ANDA | 28 sections |
Diclofenac Sodium/Misoprostoldiclofenac-sodium-misoprostol | HUMAN PRESCRIPTION DRUG LABEL | 2 | 42571-134 | TABLET | 200 ug | ORAL | ANDA | 28 sections |
Misoprostol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-707 | TABLET | 200 ug | ORAL | ANDA | 22 sections |
Misoprostol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-707 | TABLET | 200 ug | ORAL | ANDA | 22 sections |
Misoprostol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43386-160 | TABLET | 100 ug | ORAL | ANDA | 22 sections |
Misoprostol | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43386-161 | TABLET | 200 ug | ORAL | ANDA | 22 sections |