Stem definition | Drug id | CAS RN |
---|---|---|
psychoactive | 1816 | 85650-52-8 |
Dose | Unit | Route |
---|---|---|
30 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.50 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 2 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 2.83 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 50 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 4.20 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 8 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.15 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 15 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
June 14, 1996 | FDA | ORGANON USA INC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Intentional overdose | 595.33 | 10.21 | 675 | 88323 | 64269 | 46532795 |
Intentional self-injury | 500.52 | 10.21 | 395 | 88603 | 23771 | 46573293 |
Serotonin syndrome | 450.96 | 10.21 | 372 | 88626 | 23848 | 46573216 |
Suicide attempt | 426.29 | 10.21 | 525 | 88473 | 54511 | 46542553 |
Toxicity to various agents | 425.37 | 10.21 | 1116 | 87882 | 210650 | 46386414 |
Drug abuse | 415.94 | 10.21 | 557 | 88441 | 62851 | 46534213 |
Sopor | 376.34 | 10.21 | 308 | 88690 | 19520 | 46577544 |
Electrocardiogram QT prolonged | 315.50 | 10.21 | 437 | 88561 | 50888 | 46546176 |
Suicidal ideation | 302.51 | 10.21 | 450 | 88548 | 55932 | 46541132 |
Drug interaction | 299.87 | 10.21 | 959 | 88039 | 202135 | 46394929 |
Completed suicide | 295.57 | 10.21 | 772 | 88226 | 145148 | 46451916 |
Rheumatoid arthritis | 274.85 | 10.21 | 61 | 88937 | 240154 | 46356910 |
Overdose | 261.41 | 10.21 | 591 | 88407 | 101388 | 46495676 |
Hyponatraemia | 246.20 | 10.21 | 575 | 88423 | 100757 | 46496307 |
Agitation | 209.96 | 10.21 | 378 | 88620 | 55037 | 46542027 |
Somnolence | 209.21 | 10.21 | 715 | 88283 | 155806 | 46441258 |
Confusional state | 187.68 | 10.21 | 700 | 88298 | 159192 | 46437872 |
Depressed level of consciousness | 171.97 | 10.21 | 318 | 88680 | 47251 | 46549813 |
Inappropriate antidiuretic hormone secretion | 154.16 | 10.21 | 161 | 88837 | 13941 | 46583123 |
Depression | 140.44 | 10.21 | 669 | 88329 | 169435 | 46427629 |
Drug ineffective | 137.49 | 10.21 | 747 | 88251 | 677091 | 45919973 |
Muscle rigidity | 135.30 | 10.21 | 128 | 88870 | 9833 | 46587231 |
Tremor | 134.50 | 10.21 | 505 | 88493 | 115134 | 46481930 |
Neuroleptic malignant syndrome | 134.34 | 10.21 | 134 | 88864 | 10988 | 46586076 |
Coma | 131.75 | 10.21 | 322 | 88676 | 58027 | 46539037 |
Disorientation | 129.91 | 10.21 | 244 | 88754 | 36674 | 46560390 |
Tachycardia | 129.37 | 10.21 | 451 | 88547 | 99171 | 46497893 |
Restlessness | 124.48 | 10.21 | 195 | 88803 | 25329 | 46571735 |
Depressed mood | 115.73 | 10.21 | 219 | 88779 | 33100 | 46563964 |
Disturbance in attention | 115.31 | 10.21 | 212 | 88786 | 31348 | 46565716 |
Fall | 112.47 | 10.21 | 1037 | 87961 | 328060 | 46269004 |
Treatment failure | 111.77 | 10.21 | 21 | 88977 | 93066 | 46503998 |
Anxiety | 105.61 | 10.21 | 650 | 88348 | 181307 | 46415757 |
Joint swelling | 103.94 | 10.21 | 98 | 88900 | 165975 | 46431089 |
Sinusitis | 102.58 | 10.21 | 60 | 88938 | 129708 | 46467356 |
Akathisia | 98.85 | 10.21 | 96 | 88902 | 7618 | 46589446 |
Drug hypersensitivity | 98.24 | 10.21 | 198 | 88800 | 243627 | 46353437 |
Rash | 96.65 | 10.21 | 352 | 88646 | 356160 | 46240904 |
Mydriasis | 90.32 | 10.21 | 106 | 88892 | 10447 | 46586617 |
Aggression | 88.45 | 10.21 | 157 | 88841 | 22587 | 46574477 |
Restless legs syndrome | 84.23 | 10.21 | 126 | 88872 | 15717 | 46581347 |
Infusion related reaction | 82.55 | 10.21 | 45 | 88953 | 101163 | 46495901 |
Injection site pain | 81.25 | 10.21 | 52 | 88946 | 107100 | 46489964 |
Dysarthria | 80.46 | 10.21 | 203 | 88795 | 37295 | 46559769 |
General physical health deterioration | 79.10 | 10.21 | 432 | 88566 | 115337 | 46481727 |
Pain | 78.99 | 10.21 | 559 | 88439 | 476389 | 46120675 |
Nasopharyngitis | 78.77 | 10.21 | 107 | 88891 | 153891 | 46443173 |
Nightmare | 78.42 | 10.21 | 125 | 88873 | 16473 | 46580591 |
Hallucination | 78.13 | 10.21 | 241 | 88757 | 49710 | 46547354 |
Urinary retention | 78.05 | 10.21 | 161 | 88837 | 25900 | 46571164 |
Rheumatoid factor negative | 78.05 | 10.21 | 32 | 88966 | 525 | 46596539 |
Dissociation | 77.63 | 10.21 | 47 | 88951 | 1830 | 46595234 |
Systemic lupus erythematosus | 77.61 | 10.21 | 15 | 88983 | 65165 | 46531899 |
Arthralgia | 77.34 | 10.21 | 395 | 88603 | 364208 | 46232856 |
Parkinsonism | 75.05 | 10.21 | 84 | 88914 | 7864 | 46589200 |
Dyskinesia | 72.16 | 10.21 | 166 | 88832 | 28759 | 46568305 |
Arthropathy | 71.53 | 10.21 | 36 | 88962 | 84664 | 46512400 |
Depersonalisation/derealisation disorder | 71.35 | 10.21 | 36 | 88962 | 974 | 46596090 |
Withdrawal syndrome | 70.29 | 10.21 | 125 | 88873 | 18009 | 46579055 |
Pemphigus | 70.06 | 10.21 | 4 | 88994 | 45270 | 46551794 |
Pleurothotonus | 69.31 | 10.21 | 37 | 88961 | 1128 | 46595936 |
Alopecia | 68.74 | 10.21 | 128 | 88870 | 162286 | 46434778 |
Sedation | 67.98 | 10.21 | 141 | 88857 | 22769 | 46574295 |
Urticaria | 67.56 | 10.21 | 75 | 88923 | 117817 | 46479247 |
Myoclonus | 66.32 | 10.21 | 107 | 88891 | 14245 | 46582819 |
Depressive symptom | 64.43 | 10.21 | 49 | 88949 | 2787 | 46594277 |
Drug withdrawal syndrome | 62.71 | 10.21 | 152 | 88846 | 27232 | 46569832 |
Hallucination, visual | 62.69 | 10.21 | 118 | 88880 | 17755 | 46579309 |
Delirium | 62.34 | 10.21 | 184 | 88814 | 37044 | 46560020 |
Poisoning | 61.51 | 10.21 | 102 | 88896 | 13892 | 46583172 |
Peripheral swelling | 61.37 | 10.21 | 131 | 88867 | 157940 | 46439124 |
Swelling | 61.18 | 10.21 | 89 | 88909 | 124422 | 46472642 |
Seizure | 61.17 | 10.21 | 423 | 88575 | 122631 | 46474433 |
Contraindicated product administered | 60.32 | 10.21 | 39 | 88959 | 79908 | 46517156 |
Tardive dyskinesia | 60 | 10.21 | 73 | 88925 | 7470 | 46589594 |
Hyperhidrosis | 58.14 | 10.21 | 329 | 88669 | 88979 | 46508085 |
Gastric pH decreased | 57.73 | 10.21 | 23 | 88975 | 349 | 46596715 |
Psychotic disorder | 56.62 | 10.21 | 130 | 88868 | 22491 | 46574573 |
Injection site erythema | 53.88 | 10.21 | 38 | 88960 | 74389 | 46522675 |
Intestinal pseudo-obstruction | 53.74 | 10.21 | 26 | 88972 | 641 | 46596423 |
Feeling of despair | 51.97 | 10.21 | 36 | 88962 | 1769 | 46595295 |
Abdominal discomfort | 51.70 | 10.21 | 134 | 88864 | 151031 | 46446033 |
Extrapyramidal disorder | 50.69 | 10.21 | 83 | 88915 | 11185 | 46585879 |
Cough | 50.12 | 10.21 | 247 | 88751 | 230002 | 46367062 |
Loss of consciousness | 49.67 | 10.21 | 365 | 88633 | 107873 | 46489191 |
Mania | 48.94 | 10.21 | 80 | 88918 | 10766 | 46586298 |
Headache | 48.62 | 10.21 | 632 | 88366 | 477720 | 46119344 |
Injection site pruritus | 47.61 | 10.21 | 9 | 88989 | 39734 | 46557330 |
Drug intolerance | 47.54 | 10.21 | 134 | 88864 | 146915 | 46450149 |
Psychomotor retardation | 46.70 | 10.21 | 43 | 88955 | 3190 | 46593874 |
Pruritus | 46.64 | 10.21 | 271 | 88727 | 242081 | 46354983 |
Asphyxia | 46.41 | 10.21 | 54 | 88944 | 5272 | 46591792 |
Drug dependence | 45.07 | 10.21 | 110 | 88888 | 19791 | 46577273 |
Sleep disorder | 44.44 | 10.21 | 192 | 88806 | 46603 | 46550461 |
Hallucination, auditory | 44.09 | 10.21 | 76 | 88922 | 10680 | 46586384 |
Hypertonia | 43.54 | 10.21 | 48 | 88950 | 4418 | 46592646 |
Pain in extremity | 43.25 | 10.21 | 302 | 88696 | 258378 | 46338686 |
Sleep paralysis | 42.97 | 10.21 | 20 | 88978 | 451 | 46596613 |
Hyperkinesia | 42.70 | 10.21 | 32 | 88966 | 1780 | 46595284 |
Progressive multifocal leukoencephalopathy | 42.42 | 10.21 | 77 | 88921 | 11269 | 46585795 |
Accidental overdose | 42.38 | 10.21 | 108 | 88890 | 19958 | 46577106 |
Psoriasis | 41.81 | 10.21 | 53 | 88945 | 78551 | 46518513 |
Therapeutic product effect decreased | 41.59 | 10.21 | 58 | 88940 | 82543 | 46514521 |
Cogwheel rigidity | 41.22 | 10.21 | 29 | 88969 | 1461 | 46595603 |
Hypertonia neonatal | 41.14 | 10.21 | 16 | 88982 | 227 | 46596837 |
Synovitis | 40.62 | 10.21 | 34 | 88964 | 61041 | 46536023 |
Polydipsia | 40.50 | 10.21 | 40 | 88958 | 3239 | 46593825 |
Arthritis | 40.23 | 10.21 | 53 | 88945 | 77263 | 46519801 |
Psoriatic arthropathy | 40.00 | 10.21 | 10 | 88988 | 36369 | 46560695 |
Psychomotor hyperactivity | 39.50 | 10.21 | 68 | 88930 | 9545 | 46587519 |
Product dose omission issue | 38.86 | 10.21 | 177 | 88821 | 168343 | 46428721 |
Glossodynia | 38.76 | 10.21 | 18 | 88980 | 44355 | 46552709 |
Nasal congestion | 38.34 | 10.21 | 22 | 88976 | 48091 | 46548973 |
Hypersensitivity | 38.28 | 10.21 | 152 | 88846 | 150169 | 46446895 |
Device expulsion | 38.22 | 10.21 | 4 | 88994 | 27538 | 46569526 |
Acute motor-sensory axonal neuropathy | 37.63 | 10.21 | 17 | 88981 | 357 | 46596707 |
Abnormal dreams | 37.47 | 10.21 | 69 | 88929 | 10210 | 46586854 |
Major depression | 36.70 | 10.21 | 54 | 88944 | 6636 | 46590428 |
Erythema | 36.63 | 10.21 | 144 | 88854 | 142676 | 46454388 |
Dystonia | 36.63 | 10.21 | 72 | 88926 | 11185 | 46585879 |
Abnormal behaviour | 36.13 | 10.21 | 105 | 88893 | 20953 | 46576111 |
Back pain | 35.69 | 10.21 | 244 | 88754 | 209795 | 46387269 |
Galactorrhoea | 35.62 | 10.21 | 40 | 88958 | 3757 | 46593307 |
Derealisation | 35.53 | 10.21 | 21 | 88977 | 782 | 46596282 |
Rhabdomyolysis | 35.33 | 10.21 | 166 | 88832 | 41743 | 46555321 |
Product prescribing error | 33.47 | 10.21 | 99 | 88899 | 19948 | 46577116 |
Delusion | 33.35 | 10.21 | 69 | 88929 | 11119 | 46585945 |
Persecutory delusion | 33.12 | 10.21 | 32 | 88966 | 2523 | 46594541 |
Fracture | 33.08 | 10.21 | 87 | 88911 | 16384 | 46580680 |
Opisthotonus | 32.90 | 10.21 | 15 | 88983 | 322 | 46596742 |
Panic attack | 32.89 | 10.21 | 99 | 88899 | 20143 | 46576921 |
Off label use | 32.83 | 10.21 | 518 | 88480 | 379323 | 46217741 |
Cognitive disorder | 32.50 | 10.21 | 148 | 88850 | 36735 | 46560329 |
Altered state of consciousness | 32.27 | 10.21 | 108 | 88890 | 23240 | 46573824 |
Abulia | 32.24 | 10.21 | 15 | 88983 | 338 | 46596726 |
Gestational diabetes | 32.24 | 10.21 | 53 | 88945 | 7166 | 46589898 |
Unresponsive to stimuli | 32.09 | 10.21 | 134 | 88864 | 32040 | 46565024 |
Bradypnoea | 31.97 | 10.21 | 34 | 88964 | 3005 | 46594059 |
Anger | 31.76 | 10.21 | 70 | 88928 | 11782 | 46585282 |
Product administration error | 31.73 | 10.21 | 96 | 88902 | 19585 | 46577479 |
Asthma | 31.39 | 10.21 | 81 | 88917 | 91461 | 46505603 |
Histrionic personality disorder | 30.55 | 10.21 | 9 | 88989 | 50 | 46597014 |
Orthostatic hypotension | 30.55 | 10.21 | 110 | 88888 | 24548 | 46572516 |
Injection site bruising | 30.29 | 10.21 | 15 | 88983 | 35621 | 46561443 |
Herpes zoster | 30.02 | 10.21 | 52 | 88946 | 67820 | 46529244 |
Paranoia | 30.01 | 10.21 | 64 | 88934 | 10533 | 46586531 |
Injection site swelling | 29.97 | 10.21 | 20 | 88978 | 40307 | 46556757 |
Coma scale abnormal | 29.79 | 10.21 | 42 | 88956 | 4964 | 46592100 |
Cardiac arrest | 29.78 | 10.21 | 283 | 88715 | 90116 | 46506948 |
C-reactive protein abnormal | 29.74 | 10.21 | 3 | 88995 | 21267 | 46575797 |
Incontinence | 29.61 | 10.21 | 61 | 88937 | 9801 | 46587263 |
Pallor | 29.26 | 10.21 | 104 | 88894 | 23062 | 46574002 |
Rhonchi | 29.20 | 10.21 | 28 | 88970 | 2187 | 46594877 |
Drooling | 28.74 | 10.21 | 33 | 88965 | 3176 | 46593888 |
Product use issue | 28.58 | 10.21 | 89 | 88909 | 94555 | 46502509 |
Miosis | 28.56 | 10.21 | 48 | 88950 | 6609 | 46590455 |
Dysphagia | 28.50 | 10.21 | 248 | 88750 | 77064 | 46520000 |
Self-injurious ideation | 28.30 | 10.21 | 28 | 88970 | 2272 | 46594792 |
Intentional product misuse | 28.30 | 10.21 | 170 | 88828 | 46958 | 46550106 |
Schizophrenia | 28.12 | 10.21 | 55 | 88943 | 8513 | 46588551 |
Affective disorder | 28.06 | 10.21 | 40 | 88958 | 4775 | 46592289 |
Generalised tonic-clonic seizure | 27.86 | 10.21 | 114 | 88884 | 27008 | 46570056 |
Fatigue | 27.86 | 10.21 | 917 | 88081 | 607780 | 45989284 |
Ventricular fibrillation | 27.60 | 10.21 | 65 | 88933 | 11431 | 46585633 |
Urinary hesitation | 27.40 | 10.21 | 25 | 88973 | 1833 | 46595231 |
Ballismus | 26.81 | 10.21 | 9 | 88989 | 81 | 46596983 |
Chemical burn of oral cavity | 26.43 | 10.21 | 9 | 88989 | 85 | 46596979 |
Skull malformation | 26.24 | 10.21 | 13 | 88985 | 338 | 46596726 |
Therapeutic product effect incomplete | 26.15 | 10.21 | 70 | 88928 | 78083 | 46518981 |
Language disorder | 25.46 | 10.21 | 22 | 88976 | 1501 | 46595563 |
Helplessness | 25.31 | 10.21 | 11 | 88987 | 210 | 46596854 |
Knee arthroplasty | 25.08 | 10.21 | 7 | 88991 | 23658 | 46573406 |
Agitation neonatal | 24.44 | 10.21 | 14 | 88984 | 491 | 46596573 |
Salivary hypersecretion | 24.42 | 10.21 | 44 | 88954 | 6401 | 46590663 |
Upper respiratory tract infection | 24.36 | 10.21 | 53 | 88945 | 63503 | 46533561 |
Fungal infection | 24.24 | 10.21 | 13 | 88985 | 29507 | 46567557 |
H1N1 influenza | 23.93 | 10.21 | 21 | 88977 | 1463 | 46595601 |
Irritability | 23.92 | 10.21 | 114 | 88884 | 28832 | 46568232 |
Tonic clonic movements | 23.91 | 10.21 | 19 | 88979 | 1153 | 46595911 |
Norepinephrine increased | 23.83 | 10.21 | 8 | 88990 | 72 | 46596992 |
Diarrhoea | 23.73 | 10.21 | 851 | 88147 | 558751 | 46038313 |
Blood prolactin increased | 23.60 | 10.21 | 29 | 88969 | 2998 | 46594066 |
Panic reaction | 23.52 | 10.21 | 32 | 88966 | 3657 | 46593407 |
Breast discomfort | 23.47 | 10.21 | 12 | 88986 | 334 | 46596730 |
Social avoidant behaviour | 23.44 | 10.21 | 28 | 88970 | 2811 | 46594253 |
Speech disorder | 23.35 | 10.21 | 133 | 88865 | 36034 | 46561030 |
Circulatory collapse | 23.10 | 10.21 | 92 | 88906 | 21532 | 46575532 |
CYP3A4 polymorphism | 23.09 | 10.21 | 8 | 88990 | 80 | 46596984 |
Non-cardiogenic pulmonary oedema | 23.01 | 10.21 | 14 | 88984 | 550 | 46596514 |
Pyelonephritis | 22.99 | 10.21 | 73 | 88925 | 15284 | 46581780 |
Facial nerve disorder | 22.85 | 10.21 | 14 | 88984 | 557 | 46596507 |
Personality disorder | 22.80 | 10.21 | 29 | 88969 | 3104 | 46593960 |
Infection | 22.76 | 10.21 | 155 | 88843 | 133437 | 46463627 |
Impaired healing | 22.58 | 10.21 | 22 | 88976 | 36721 | 46560343 |
Neonatal hypoxia | 22.36 | 10.21 | 13 | 88985 | 469 | 46596595 |
Mood swings | 22.30 | 10.21 | 75 | 88923 | 16177 | 46580887 |
Maternal exposure during pregnancy | 22.28 | 10.21 | 110 | 88888 | 102439 | 46494625 |
Epilepsy | 22.23 | 10.21 | 97 | 88901 | 23641 | 46573423 |
Orgasm abnormal | 22.16 | 10.21 | 8 | 88990 | 91 | 46596973 |
Myocardial infarction | 22.13 | 10.21 | 103 | 88895 | 97425 | 46499639 |
Cerebral ventricle dilatation | 22.06 | 10.21 | 17 | 88981 | 986 | 46596078 |
Giant cell arteritis | 21.89 | 10.21 | 22 | 88976 | 1819 | 46595245 |
Injection site reaction | 21.76 | 10.21 | 36 | 88962 | 47813 | 46549251 |
Alkalosis hypochloraemic | 21.71 | 10.21 | 9 | 88989 | 152 | 46596912 |
Incoherent | 21.34 | 10.21 | 34 | 88964 | 4478 | 46592586 |
Euphoric mood | 21.32 | 10.21 | 33 | 88965 | 4239 | 46592825 |
Tachycardia paroxysmal | 21.17 | 10.21 | 11 | 88987 | 317 | 46596747 |
Pneumonia | 21.14 | 10.21 | 551 | 88447 | 375769 | 46221295 |
Hypophagia | 21.09 | 10.21 | 111 | 88887 | 29195 | 46567869 |
Insomnia | 21.05 | 10.21 | 436 | 88562 | 164488 | 46432576 |
Agranulocytosis | 21.04 | 10.21 | 91 | 88907 | 22094 | 46574970 |
Osteoporosis | 20.95 | 10.21 | 28 | 88970 | 40580 | 46556484 |
Feeling jittery | 20.95 | 10.21 | 57 | 88941 | 10951 | 46586113 |
Respiratory distress | 20.93 | 10.21 | 18 | 88980 | 31898 | 46565166 |
Platelet count decreased | 20.76 | 10.21 | 109 | 88889 | 99915 | 46497149 |
Apathy | 20.70 | 10.21 | 44 | 88954 | 7224 | 46589840 |
Neuropathy peripheral | 20.62 | 10.21 | 96 | 88902 | 90797 | 46506267 |
Injection site haemorrhage | 20.38 | 10.21 | 7 | 88991 | 20702 | 46576362 |
Immune reconstitution inflammatory syndrome | 20.33 | 10.21 | 38 | 88960 | 5687 | 46591377 |
Mutism | 20.17 | 10.21 | 18 | 88980 | 1282 | 46595782 |
Autonomic nervous system imbalance | 20.15 | 10.21 | 24 | 88974 | 2402 | 46594662 |
Product quality issue | 20.05 | 10.21 | 23 | 88975 | 35625 | 46561439 |
Hyperthermia | 19.99 | 10.21 | 46 | 88952 | 7968 | 46589096 |
Suicidal behaviour | 19.97 | 10.21 | 24 | 88974 | 2424 | 46594640 |
Cataract | 19.89 | 10.21 | 35 | 88963 | 45380 | 46551684 |
Thinking abnormal | 19.87 | 10.21 | 52 | 88946 | 9762 | 46587302 |
Aphasia | 19.74 | 10.21 | 107 | 88891 | 28460 | 46568604 |
Impulsive behaviour | 19.68 | 10.21 | 19 | 88979 | 1496 | 46595568 |
Cardiac failure congestive | 19.59 | 10.21 | 99 | 88899 | 91651 | 46505413 |
Thymus disorder | 19.58 | 10.21 | 9 | 88989 | 197 | 46596867 |
Purple glove syndrome | 19.54 | 10.21 | 9 | 88989 | 198 | 46596866 |
Parosmia | 19.44 | 10.21 | 31 | 88967 | 4085 | 46592979 |
Bradyphrenia | 19.25 | 10.21 | 39 | 88959 | 6191 | 46590873 |
Visceral congestion | 19.22 | 10.21 | 10 | 88988 | 289 | 46596775 |
Merycism | 19.20 | 10.21 | 8 | 88990 | 137 | 46596927 |
Drug dose titration not performed | 19.15 | 10.21 | 11 | 88987 | 388 | 46596676 |
Reduced facial expression | 19.14 | 10.21 | 17 | 88981 | 1203 | 46595861 |
Thirst | 19.09 | 10.21 | 55 | 88943 | 10921 | 46586143 |
Natural killer cell count decreased | 19.07 | 10.21 | 6 | 88992 | 43 | 46597021 |
Respiratory arrest | 19.05 | 10.21 | 120 | 88878 | 33696 | 46563368 |
Respiratory disorder neonatal | 18.83 | 10.21 | 15 | 88983 | 913 | 46596151 |
Skin exfoliation | 18.80 | 10.21 | 21 | 88977 | 32917 | 46564147 |
Intentional product use issue | 18.63 | 10.21 | 46 | 88952 | 52734 | 46544330 |
Sensorimotor disorder | 18.58 | 10.21 | 11 | 88987 | 411 | 46596653 |
Cellulitis orbital | 18.55 | 10.21 | 11 | 88987 | 412 | 46596652 |
Spina bifida | 18.55 | 10.21 | 13 | 88985 | 651 | 46596413 |
Decreased appetite | 18.45 | 10.21 | 492 | 88506 | 193344 | 46403720 |
Activation syndrome | 18.41 | 10.21 | 9 | 88989 | 227 | 46596837 |
Osteoarthritis | 18.24 | 10.21 | 59 | 88939 | 61966 | 46535098 |
Cytomegalovirus infection | 18.08 | 10.21 | 6 | 88992 | 18138 | 46578926 |
Cellulitis | 17.92 | 10.21 | 71 | 88927 | 70217 | 46526847 |
Syncope | 17.90 | 10.21 | 290 | 88708 | 104513 | 46492551 |
Chest pain | 17.80 | 10.21 | 233 | 88765 | 176091 | 46420973 |
Aspiration | 17.79 | 10.21 | 49 | 88949 | 9482 | 46587582 |
Drop attacks | 17.75 | 10.21 | 13 | 88985 | 698 | 46596366 |
Acute abdomen | 17.66 | 10.21 | 18 | 88980 | 1514 | 46595550 |
Cerebellar syndrome | 17.62 | 10.21 | 27 | 88971 | 3438 | 46593626 |
Bradykinesia | 17.55 | 10.21 | 29 | 88969 | 3937 | 46593127 |
Hypokalaemia | 17.51 | 10.21 | 250 | 88748 | 87774 | 46509290 |
Bursitis | 17.40 | 10.21 | 8 | 88990 | 19834 | 46577230 |
Phagophobia | 17.25 | 10.21 | 5 | 88993 | 26 | 46597038 |
Empty sella syndrome | 17.25 | 10.21 | 5 | 88993 | 26 | 46597038 |
Dementia | 17.15 | 10.21 | 65 | 88933 | 14865 | 46582199 |
Agonal rhythm | 17.09 | 10.21 | 5 | 88993 | 27 | 46597037 |
Poisoning deliberate | 17.09 | 10.21 | 43 | 88955 | 7883 | 46589181 |
Retinal detachment | 17.05 | 10.21 | 33 | 88965 | 5067 | 46591997 |
Binge eating | 16.98 | 10.21 | 10 | 88988 | 370 | 46596694 |
Mental disorder | 16.87 | 10.21 | 86 | 88912 | 22339 | 46574725 |
Inflammation | 16.84 | 10.21 | 43 | 88955 | 48738 | 46548326 |
Radial nerve palsy | 16.71 | 10.21 | 10 | 88988 | 381 | 46596683 |
Pulmonary renal syndrome | 16.69 | 10.21 | 10 | 88988 | 382 | 46596682 |
Gastrooesophageal reflux disease | 16.58 | 10.21 | 79 | 88919 | 74265 | 46522799 |
Dyspraxia | 16.54 | 10.21 | 8 | 88990 | 197 | 46596867 |
Febrile neutropenia | 16.51 | 10.21 | 109 | 88889 | 94518 | 46502546 |
Blood pressure increased | 16.49 | 10.21 | 158 | 88840 | 126508 | 46470556 |
Rhinorrhoea | 16.47 | 10.21 | 42 | 88956 | 47623 | 46549441 |
Tachyphrenia | 16.38 | 10.21 | 16 | 88982 | 1278 | 46595786 |
Abnormal weight gain | 16.37 | 10.21 | 17 | 88981 | 1461 | 46595603 |
No adverse event | 16.28 | 10.21 | 25 | 88973 | 34206 | 46562858 |
Chorea | 16.15 | 10.21 | 15 | 88983 | 1125 | 46595939 |
Vitamin B12 decreased | 16.09 | 10.21 | 23 | 88975 | 2752 | 46594312 |
Negative thoughts | 16.03 | 10.21 | 13 | 88985 | 812 | 46596252 |
Sudden death | 15.93 | 10.21 | 47 | 88951 | 9457 | 46587607 |
Drug withdrawal syndrome neonatal | 15.89 | 10.21 | 19 | 88979 | 1909 | 46595155 |
Loss of libido | 15.82 | 10.21 | 16 | 88982 | 1333 | 46595731 |
Productive cough | 15.79 | 10.21 | 47 | 88951 | 50668 | 46546396 |
Brief psychotic disorder with marked stressors | 15.76 | 10.21 | 6 | 88992 | 80 | 46596984 |
Medulloblastoma | 15.75 | 10.21 | 5 | 88993 | 37 | 46597027 |
Aspergillus test positive | 15.65 | 10.21 | 9 | 88989 | 318 | 46596746 |
Intrusive thoughts | 15.54 | 10.21 | 7 | 88991 | 146 | 46596918 |
Drowning | 15.44 | 10.21 | 10 | 88988 | 439 | 46596625 |
Interstitial lung disease | 15.40 | 10.21 | 52 | 88946 | 53897 | 46543167 |
Palmar-plantar erythrodysaesthesia syndrome | 15.38 | 10.21 | 10 | 88988 | 20441 | 46576623 |
Enterococcus test positive | 15.34 | 10.21 | 14 | 88984 | 1027 | 46596037 |
Anaphylactic reaction | 15.29 | 10.21 | 51 | 88947 | 53061 | 46544003 |
Retrograde amnesia | 15.25 | 10.21 | 9 | 88989 | 334 | 46596730 |
Homicidal ideation | 15.25 | 10.21 | 18 | 88980 | 1784 | 46595280 |
Substance abuse | 15.22 | 10.21 | 28 | 88970 | 4139 | 46592925 |
Cardiac hypertrophy | 15.15 | 10.21 | 14 | 88984 | 1043 | 46596021 |
Gamma-glutamyltransferase increased | 15.09 | 10.21 | 108 | 88890 | 31632 | 46565432 |
Joint range of motion decreased | 15.07 | 10.21 | 5 | 88993 | 15119 | 46581945 |
Snoring | 15.01 | 10.21 | 25 | 88973 | 3417 | 46593647 |
Influenza | 14.99 | 10.21 | 104 | 88894 | 89166 | 46507898 |
Mental impairment | 14.95 | 10.21 | 55 | 88943 | 12401 | 46584663 |
Nephrolithiasis | 14.91 | 10.21 | 25 | 88973 | 33026 | 46564038 |
Pyroglutamic acidosis | 14.83 | 10.21 | 8 | 88990 | 249 | 46596815 |
Cardio-respiratory arrest | 14.82 | 10.21 | 177 | 88821 | 59692 | 46537372 |
Feeling of body temperature change | 14.82 | 10.21 | 28 | 88970 | 4224 | 46592840 |
Pneumonia aspiration | 14.72 | 10.21 | 107 | 88891 | 31498 | 46565566 |
Compulsive sexual behaviour | 14.70 | 10.21 | 5 | 88993 | 47 | 46597017 |
Disseminated intravascular coagulation | 14.70 | 10.21 | 9 | 88989 | 18996 | 46578068 |
Bundle branch block right | 14.69 | 10.21 | 30 | 88968 | 4789 | 46592275 |
Neck pain | 14.66 | 10.21 | 55 | 88943 | 55251 | 46541813 |
Developmental hip dysplasia | 14.65 | 10.21 | 15 | 88983 | 1268 | 46595796 |
Granulocytopenia neonatal | 14.65 | 10.21 | 4 | 88994 | 16 | 46597048 |
Status epilepticus | 14.55 | 10.21 | 59 | 88939 | 13920 | 46583144 |
Injection site rash | 14.46 | 10.21 | 6 | 88992 | 15807 | 46581257 |
Viral infection | 14.46 | 10.21 | 22 | 88976 | 30213 | 46566851 |
Dyspnoea | 14.45 | 10.21 | 820 | 88178 | 514728 | 46082336 |
Psychiatric decompensation | 14.43 | 10.21 | 14 | 88984 | 1109 | 46595955 |
Therapy non-responder | 14.42 | 10.21 | 36 | 88962 | 41116 | 46555948 |
Basophil count decreased | 14.39 | 10.21 | 6 | 88992 | 103 | 46596961 |
Logorrhoea | 14.35 | 10.21 | 20 | 88978 | 2339 | 46594725 |
Bronchitis | 14.31 | 10.21 | 131 | 88867 | 105848 | 46491216 |
Antidepressant drug level increased | 14.22 | 10.21 | 8 | 88990 | 271 | 46596793 |
Vasodilatation | 14.18 | 10.21 | 20 | 88978 | 2365 | 46594699 |
Motor dysfunction | 14.15 | 10.21 | 38 | 88960 | 7244 | 46589820 |
Nausea | 14.15 | 10.21 | 1124 | 87874 | 686330 | 45910734 |
Tearfulness | 14.13 | 10.21 | 27 | 88971 | 4108 | 46592956 |
Shared psychotic disorder | 14.10 | 10.21 | 4 | 88994 | 19 | 46597045 |
Indifference | 14.08 | 10.21 | 6 | 88992 | 109 | 46596955 |
Selective eating disorder | 14.06 | 10.21 | 17 | 88981 | 1728 | 46595336 |
Vagus nerve disorder | 14.03 | 10.21 | 6 | 88992 | 110 | 46596954 |
Tongue movement disturbance | 14.02 | 10.21 | 7 | 88991 | 185 | 46596879 |
Neglect of personal appearance | 13.98 | 10.21 | 6 | 88992 | 111 | 46596953 |
Hypothermia | 13.96 | 10.21 | 53 | 88945 | 12130 | 46584934 |
Coronary artery disease | 13.90 | 10.21 | 27 | 88971 | 33725 | 46563339 |
Acute psychosis | 13.81 | 10.21 | 18 | 88980 | 1974 | 46595090 |
Chemical burns of eye | 13.77 | 10.21 | 5 | 88993 | 58 | 46597006 |
Congenital hand malformation | 13.75 | 10.21 | 8 | 88990 | 289 | 46596775 |
Intestinal mucosal atrophy | 13.72 | 10.21 | 3 | 88995 | 3 | 46597061 |
Pyrexia | 13.71 | 10.21 | 535 | 88463 | 348267 | 46248797 |
Bulimia nervosa | 13.68 | 10.21 | 10 | 88988 | 535 | 46596529 |
Flushing | 13.63 | 10.21 | 70 | 88928 | 64544 | 46532520 |
Akinesia | 13.63 | 10.21 | 17 | 88981 | 1784 | 46595280 |
Polydipsia psychogenic | 13.54 | 10.21 | 5 | 88993 | 61 | 46597003 |
Hip arthroplasty | 13.43 | 10.21 | 9 | 88989 | 18103 | 46578961 |
Refusal of treatment by patient | 13.41 | 10.21 | 31 | 88967 | 5384 | 46591680 |
Fluid retention | 13.37 | 10.21 | 51 | 88947 | 50995 | 46546069 |
Helicobacter infection | 13.35 | 10.21 | 3 | 88995 | 11733 | 46585331 |
Poor feeding infant | 13.34 | 10.21 | 7 | 88991 | 206 | 46596858 |
Post-traumatic stress disorder | 13.30 | 10.21 | 26 | 88972 | 4022 | 46593042 |
Stupor | 13.30 | 10.21 | 24 | 88974 | 3496 | 46593568 |
Cyanosis | 13.27 | 10.21 | 63 | 88935 | 15908 | 46581156 |
Mixed anxiety and depressive disorder | 13.20 | 10.21 | 6 | 88992 | 128 | 46596936 |
Rabbit syndrome | 13.13 | 10.21 | 8 | 88990 | 315 | 46596749 |
B-lymphocyte count increased | 13.11 | 10.21 | 6 | 88992 | 130 | 46596934 |
Postmortem blood drug level increased | 13.10 | 10.21 | 9 | 88989 | 436 | 46596628 |
Decubitus ulcer | 12.99 | 10.21 | 45 | 88953 | 9853 | 46587211 |
Dyspnoea at rest | 12.97 | 10.21 | 24 | 88974 | 3564 | 46593500 |
White blood cell count decreased | 12.96 | 10.21 | 144 | 88854 | 112087 | 46484977 |
Optic nerve disorder | 12.95 | 10.21 | 11 | 88987 | 733 | 46596331 |
Psychotic symptom | 12.94 | 10.21 | 12 | 88986 | 898 | 46596166 |
Staphylococcal infection | 12.76 | 10.21 | 31 | 88967 | 35740 | 46561324 |
Phaeochromocytoma | 12.70 | 10.21 | 9 | 88989 | 459 | 46596605 |
Premature delivery | 12.67 | 10.21 | 14 | 88984 | 22055 | 46575009 |
Somatic delusion | 12.64 | 10.21 | 10 | 88988 | 603 | 46596461 |
Resuscitation | 12.63 | 10.21 | 13 | 88985 | 1106 | 46595958 |
Postural tremor | 12.63 | 10.21 | 6 | 88992 | 142 | 46596922 |
Red blood cell sedimentation rate increased | 12.62 | 10.21 | 15 | 88983 | 22874 | 46574190 |
Haemoptysis | 12.57 | 10.21 | 19 | 88979 | 26170 | 46570894 |
Infantile apnoea | 12.55 | 10.21 | 11 | 88987 | 765 | 46596299 |
Skin ulcer | 12.49 | 10.21 | 27 | 88971 | 32431 | 46564633 |
Peripheral paralysis | 12.48 | 10.21 | 5 | 88993 | 77 | 46596987 |
Parkinson's disease | 12.41 | 10.21 | 15 | 88983 | 1524 | 46595540 |
Hypotension | 12.40 | 10.21 | 552 | 88446 | 232037 | 46365027 |
Medication error | 12.36 | 10.21 | 101 | 88897 | 30810 | 46566254 |
Orthostatic intolerance | 12.30 | 10.21 | 13 | 88985 | 1141 | 46595923 |
Agoraphobia | 12.25 | 10.21 | 8 | 88990 | 356 | 46596708 |
Breast cancer | 12.23 | 10.21 | 45 | 88953 | 45473 | 46551591 |
Catatonia | 12.16 | 10.21 | 24 | 88974 | 3738 | 46593326 |
Transfusion | 12.13 | 10.21 | 5 | 88993 | 13226 | 46583838 |
Respiratory depression | 12.10 | 10.21 | 49 | 88949 | 11551 | 46585513 |
Cerebellar haematoma | 12.06 | 10.21 | 8 | 88990 | 366 | 46596698 |
Blood pressure diastolic decreased | 12.05 | 10.21 | 6 | 88992 | 14205 | 46582859 |
Therapeutic response decreased | 12.03 | 10.21 | 42 | 88956 | 43103 | 46553961 |
Maternal drugs affecting foetus | 11.96 | 10.21 | 30 | 88968 | 5488 | 46591576 |
Antiphospholipid antibodies | 11.94 | 10.21 | 6 | 88992 | 161 | 46596903 |
Hyperreflexia | 11.85 | 10.21 | 29 | 88969 | 5225 | 46591839 |
Hallucinations, mixed | 11.78 | 10.21 | 24 | 88974 | 3825 | 46593239 |
Neurological decompensation | 11.74 | 10.21 | 16 | 88982 | 1832 | 46595232 |
Dreamy state | 11.73 | 10.21 | 4 | 88994 | 38 | 46597026 |
Anaemia | 11.70 | 10.21 | 385 | 88613 | 255394 | 46341670 |
Inappropriate affect | 11.69 | 10.21 | 11 | 88987 | 839 | 46596225 |
Sinus tachycardia | 11.68 | 10.21 | 76 | 88922 | 21573 | 46575491 |
Fibula agenesis | 11.65 | 10.21 | 3 | 88995 | 9 | 46597055 |
Sepsis | 11.53 | 10.21 | 186 | 88812 | 135828 | 46461236 |
Foetal exposure during pregnancy | 11.51 | 10.21 | 99 | 88899 | 30648 | 46566416 |
Generalised anxiety disorder | 11.51 | 10.21 | 15 | 88983 | 1645 | 46595419 |
Gamma-glutamyltransferase abnormal | 11.50 | 10.21 | 7 | 88991 | 275 | 46596789 |
Anaphylactic shock | 11.49 | 10.21 | 13 | 88985 | 20261 | 46576803 |
Haematemesis | 11.45 | 10.21 | 94 | 88904 | 28712 | 46568352 |
Injection site warmth | 11.40 | 10.21 | 6 | 88992 | 13766 | 46583298 |
Increased appetite | 11.39 | 10.21 | 39 | 88959 | 8488 | 46588576 |
Hypoaesthesia oral | 11.34 | 10.21 | 45 | 88953 | 10514 | 46586550 |
Respiration abnormal | 11.33 | 10.21 | 26 | 88972 | 4495 | 46592569 |
Skin lesion | 11.33 | 10.21 | 21 | 88977 | 26692 | 46570372 |
Formication | 11.33 | 10.21 | 24 | 88974 | 3932 | 46593132 |
Sinus disorder | 11.28 | 10.21 | 9 | 88989 | 16554 | 46580510 |
Gastrointestinal disorder | 11.23 | 10.21 | 67 | 88931 | 59509 | 46537555 |
Antipsychotic drug level below therapeutic | 11.15 | 10.21 | 7 | 88991 | 291 | 46596773 |
Muscle disorder | 11.13 | 10.21 | 25 | 88973 | 4261 | 46592803 |
Catastrophic reaction | 10.99 | 10.21 | 3 | 88995 | 12 | 46597052 |
Product complaint | 10.99 | 10.21 | 49 | 88949 | 12052 | 46585012 |
Vaginal haemorrhage | 10.97 | 10.21 | 20 | 88978 | 25584 | 46571480 |
Nail avulsion | 10.97 | 10.21 | 4 | 88994 | 47 | 46597017 |
Lower respiratory tract infection | 10.89 | 10.21 | 61 | 88937 | 55028 | 46542036 |
Alcoholism | 10.88 | 10.21 | 17 | 88981 | 2201 | 46594863 |
Lower limb fracture | 10.87 | 10.21 | 5 | 88993 | 12393 | 46584671 |
Faecaloma | 10.84 | 10.21 | 36 | 88962 | 7716 | 46589348 |
Mucosal inflammation | 10.83 | 10.21 | 38 | 88960 | 38938 | 46558126 |
Product availability issue | 10.81 | 10.21 | 12 | 88986 | 1113 | 46595951 |
Appetite disorder | 10.80 | 10.21 | 28 | 88970 | 5226 | 46591838 |
Suspected suicide | 10.80 | 10.21 | 26 | 88972 | 4635 | 46592429 |
Pulse absent | 10.80 | 10.21 | 27 | 88971 | 4929 | 46592135 |
Weight increased | 10.76 | 10.21 | 399 | 88599 | 164074 | 46432990 |
Compulsions | 10.75 | 10.21 | 6 | 88992 | 200 | 46596864 |
Tendonitis | 10.71 | 10.21 | 7 | 88991 | 14270 | 46582794 |
Haemoglobin decreased | 10.71 | 10.21 | 177 | 88821 | 128772 | 46468292 |
Adrenal cyst | 10.69 | 10.21 | 5 | 88993 | 114 | 46596950 |
Lipohypertrophy | 10.63 | 10.21 | 10 | 88988 | 762 | 46596302 |
Pharyngeal erythema | 10.63 | 10.21 | 14 | 88984 | 1551 | 46595513 |
Migraine | 10.60 | 10.21 | 84 | 88914 | 69942 | 46527122 |
Anticholinergic syndrome | 10.52 | 10.21 | 15 | 88983 | 1791 | 46595273 |
Sleep terror | 10.50 | 10.21 | 10 | 88988 | 774 | 46596290 |
Bifascicular block | 10.50 | 10.21 | 5 | 88993 | 119 | 46596945 |
Paresis | 10.49 | 10.21 | 16 | 88982 | 2030 | 46595034 |
C-reactive protein increased | 10.46 | 10.21 | 67 | 88931 | 58523 | 46538541 |
Polyneuropathy | 10.46 | 10.21 | 47 | 88951 | 11597 | 46585467 |
Poverty of thought content | 10.45 | 10.21 | 3 | 88995 | 15 | 46597049 |
Sinus congestion | 10.43 | 10.21 | 6 | 88992 | 13103 | 46583961 |
Nose deformity | 10.42 | 10.21 | 5 | 88993 | 121 | 46596943 |
Atrial fibrillation | 10.40 | 10.21 | 137 | 88861 | 103453 | 46493611 |
Swollen tongue | 10.37 | 10.21 | 93 | 88905 | 29139 | 46567925 |
Multiple organ dysfunction syndrome | 10.36 | 10.21 | 57 | 88941 | 51653 | 46545411 |
Hyperphagia | 10.33 | 10.21 | 14 | 88984 | 1594 | 46595470 |
Potentiating drug interaction | 10.32 | 10.21 | 23 | 88975 | 3900 | 46593164 |
Snake bite | 10.29 | 10.21 | 3 | 88995 | 16 | 46597048 |
Failure to thrive | 10.27 | 10.21 | 32 | 88966 | 6632 | 46590432 |
Injection site urticaria | 10.23 | 10.21 | 5 | 88993 | 11962 | 46585102 |
Acute myeloid leukaemia | 10.22 | 10.21 | 9 | 88989 | 15769 | 46581295 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Toxicity to various agents | 443.33 | 10.73 | 1074 | 61577 | 176109 | 29713718 |
Intentional overdose | 415.42 | 10.73 | 472 | 62179 | 41009 | 29848818 |
Intentional self-injury | 345.33 | 10.73 | 260 | 62391 | 13272 | 29876555 |
Completed suicide | 299.98 | 10.73 | 650 | 62001 | 98842 | 29790985 |
Suicide attempt | 297.32 | 10.73 | 375 | 62276 | 36322 | 29853505 |
Agitation | 230.54 | 10.73 | 409 | 62242 | 53664 | 29836163 |
Serotonin syndrome | 210.95 | 10.73 | 222 | 62429 | 17669 | 29872158 |
Overdose | 200.25 | 10.73 | 502 | 62149 | 83835 | 29805992 |
Suicidal ideation | 198.04 | 10.73 | 306 | 62345 | 35808 | 29854019 |
Somnolence | 184.43 | 10.73 | 531 | 62120 | 96232 | 29793595 |
Confusional state | 179.22 | 10.73 | 654 | 61997 | 134180 | 29755647 |
Sopor | 154.46 | 10.73 | 150 | 62501 | 10841 | 29878986 |
Drug abuse | 153.05 | 10.73 | 447 | 62204 | 81625 | 29808202 |
Anxiety | 153.02 | 10.73 | 474 | 62177 | 89397 | 29800430 |
Depression | 145.73 | 10.73 | 468 | 62183 | 89969 | 29799858 |
Restlessness | 133.07 | 10.73 | 198 | 62453 | 22401 | 29867426 |
Coma | 128.19 | 10.73 | 270 | 62381 | 40179 | 29849648 |
Restless legs syndrome | 102.63 | 10.73 | 97 | 62554 | 6775 | 29883052 |
Extrapyramidal disorder | 100.69 | 10.73 | 118 | 62533 | 10575 | 29879252 |
Fall | 92.04 | 10.73 | 673 | 61978 | 181199 | 29708628 |
Aggression | 90.93 | 10.73 | 223 | 62428 | 36684 | 29853143 |
Drug interaction | 89.02 | 10.73 | 717 | 61934 | 198851 | 29690976 |
Delirium | 88.17 | 10.73 | 234 | 62417 | 40397 | 29849430 |
Tremor | 82.36 | 10.73 | 344 | 62307 | 75019 | 29814808 |
Drug withdrawal syndrome | 81.95 | 10.73 | 148 | 62503 | 19661 | 29870166 |
Akathisia | 81.86 | 10.73 | 80 | 62571 | 5824 | 29884003 |
Electrocardiogram QT prolonged | 81.45 | 10.73 | 210 | 62441 | 35625 | 29854202 |
Nightmare | 80.12 | 10.73 | 112 | 62539 | 11964 | 29877863 |
Neuroleptic malignant syndrome | 79.53 | 10.73 | 131 | 62520 | 16164 | 29873663 |
Sedation | 79.07 | 10.73 | 131 | 62520 | 16242 | 29873585 |
Mania | 77.97 | 10.73 | 96 | 62555 | 9058 | 29880769 |
Accidental overdose | 73.64 | 10.73 | 135 | 62516 | 18140 | 29871687 |
Febrile neutropenia | 67.66 | 10.73 | 74 | 62577 | 106619 | 29783208 |
Hallucination, visual | 66.15 | 10.73 | 120 | 62531 | 15993 | 29873834 |
Wrong patient received product | 65.13 | 10.73 | 43 | 62608 | 1774 | 29888053 |
Logorrhoea | 64.46 | 10.73 | 45 | 62606 | 2037 | 29887790 |
Myoclonus | 63.60 | 10.73 | 106 | 62545 | 13206 | 29876621 |
Parkinsonism | 63.15 | 10.73 | 77 | 62574 | 7192 | 29882635 |
Depressed mood | 61.43 | 10.73 | 120 | 62531 | 16909 | 29872918 |
Muscle twitching | 60.72 | 10.73 | 80 | 62571 | 8075 | 29881752 |
Depressed level of consciousness | 60.72 | 10.73 | 197 | 62454 | 38025 | 29851802 |
Disorientation | 60.26 | 10.73 | 173 | 62478 | 31245 | 29858582 |
Interstitial lung disease | 58.98 | 10.73 | 26 | 62625 | 60171 | 29829656 |
Insomnia | 58.22 | 10.73 | 364 | 62287 | 92972 | 29796855 |
Pneumonia aspiration | 57.57 | 10.73 | 192 | 62459 | 37588 | 29852239 |
Bradyphrenia | 57.46 | 10.73 | 55 | 62596 | 3902 | 29885925 |
Abnormal behaviour | 54.98 | 10.73 | 147 | 62504 | 25476 | 29864351 |
Withdrawal syndrome | 54.30 | 10.73 | 90 | 62561 | 11160 | 29878667 |
Dyskinesia | 49.64 | 10.73 | 128 | 62523 | 21706 | 29868121 |
Panic attack | 49.56 | 10.73 | 75 | 62576 | 8606 | 29881221 |
Hallucination | 48.23 | 10.73 | 217 | 62434 | 48842 | 29840985 |
Apathy | 47.74 | 10.73 | 62 | 62589 | 6170 | 29883657 |
Delusion | 47.58 | 10.73 | 88 | 62563 | 11901 | 29877926 |
Myocardial infarction | 47.32 | 10.73 | 122 | 62529 | 125503 | 29764324 |
Psychomotor hyperactivity | 46.88 | 10.73 | 71 | 62580 | 8153 | 29881674 |
Antidepressant drug level above therapeutic | 45.64 | 10.73 | 16 | 62635 | 150 | 29889677 |
Inappropriate antidiuretic hormone secretion | 45.53 | 10.73 | 84 | 62567 | 11338 | 29878489 |
Progressive multifocal leukoencephalopathy | 44.71 | 10.73 | 73 | 62578 | 8940 | 29880887 |
Hallucination, auditory | 44.18 | 10.73 | 76 | 62575 | 9713 | 29880114 |
Sleep disorder | 43.32 | 10.73 | 131 | 62520 | 24348 | 29865479 |
Disturbance in attention | 42.57 | 10.73 | 122 | 62529 | 22007 | 29867820 |
Illusion | 42.51 | 10.73 | 24 | 62627 | 744 | 29889083 |
Poisoning | 42.01 | 10.73 | 81 | 62570 | 11301 | 29878526 |
Psychotic disorder | 41.76 | 10.73 | 119 | 62532 | 21396 | 29868431 |
Rheumatoid arthritis | 41.62 | 10.73 | 17 | 62634 | 41180 | 29848647 |
Cough | 41.44 | 10.73 | 130 | 62521 | 125512 | 29764315 |
Illness anxiety disorder | 41.32 | 10.73 | 15 | 62636 | 157 | 29889670 |
Priapism | 40.80 | 10.73 | 50 | 62601 | 4693 | 29885134 |
Antipsychotic drug level above therapeutic | 40.01 | 10.73 | 26 | 62625 | 1044 | 29888783 |
Loss of consciousness | 39.59 | 10.73 | 293 | 62358 | 79082 | 29810745 |
Platelet count decreased | 39.24 | 10.73 | 104 | 62547 | 106025 | 29783802 |
Pruritus | 39.20 | 10.73 | 122 | 62529 | 118082 | 29771745 |
Muscle rigidity | 39.08 | 10.73 | 74 | 62577 | 10187 | 29879640 |
Atrial fibrillation | 38.45 | 10.73 | 108 | 62543 | 108016 | 29781811 |
Tachycardia | 37.23 | 10.73 | 273 | 62378 | 73466 | 29816361 |
Paranoia | 36.99 | 10.73 | 72 | 62579 | 10116 | 29879711 |
Hyponatraemia | 36.36 | 10.73 | 253 | 62398 | 66949 | 29822878 |
Pneumonia | 35.72 | 10.73 | 489 | 62162 | 333817 | 29556010 |
Renal failure | 35.49 | 10.73 | 144 | 62507 | 128822 | 29761005 |
Persecutory delusion | 35.43 | 10.73 | 32 | 62619 | 2108 | 29887719 |
Mental disorder | 34.96 | 10.73 | 83 | 62568 | 13366 | 29876461 |
Nasopharyngitis | 34.92 | 10.73 | 43 | 62608 | 58806 | 29831021 |
Rhabdomyolysis | 34.77 | 10.73 | 240 | 62411 | 63340 | 29826487 |
Pyrexia | 34.30 | 10.73 | 423 | 62228 | 294066 | 29595761 |
Accidental death | 34.24 | 10.73 | 31 | 62620 | 2048 | 29887779 |
Major depression | 33.95 | 10.73 | 42 | 62609 | 3980 | 29885847 |
Disease progression | 33.70 | 10.73 | 73 | 62578 | 79801 | 29810026 |
Blood creatine phosphokinase increased | 33.15 | 10.73 | 180 | 62471 | 43668 | 29846159 |
Cardiac failure congestive | 32.51 | 10.73 | 81 | 62570 | 84326 | 29805501 |
Tardive dyskinesia | 32.20 | 10.73 | 46 | 62605 | 5011 | 29884816 |
Hypomania | 32.08 | 10.73 | 31 | 62620 | 2225 | 29887602 |
Hyponatraemic coma | 31.94 | 10.73 | 9 | 62642 | 37 | 29889790 |
Selective eating disorder | 31.52 | 10.73 | 27 | 62624 | 1657 | 29888170 |
Drug dependence | 31.35 | 10.73 | 107 | 62544 | 21188 | 29868639 |
On and off phenomenon | 30.76 | 10.73 | 34 | 62617 | 2857 | 29886970 |
Analgesic drug level above therapeutic | 29.55 | 10.73 | 13 | 62638 | 232 | 29889595 |
Poisoning deliberate | 29.52 | 10.73 | 48 | 62603 | 5856 | 29883971 |
Rash | 29.52 | 10.73 | 258 | 62393 | 191631 | 29698196 |
Prescription drug used without a prescription | 29.43 | 10.73 | 23 | 62628 | 1239 | 29888588 |
Neuropathy peripheral | 29.24 | 10.73 | 65 | 62586 | 70410 | 29819417 |
Respiratory arrest | 29.18 | 10.73 | 130 | 62521 | 29128 | 29860699 |
Anaemia | 28.84 | 10.73 | 287 | 62364 | 207705 | 29682122 |
Hyperhidrosis | 28.67 | 10.73 | 239 | 62412 | 66851 | 29822976 |
Platypnoea | 28.57 | 10.73 | 8 | 62643 | 32 | 29889795 |
Oesophageal obstruction | 28.31 | 10.73 | 15 | 62636 | 409 | 29889418 |
Miosis | 28.29 | 10.73 | 55 | 62596 | 7721 | 29882106 |
Urinary retention | 28.25 | 10.73 | 140 | 62511 | 32777 | 29857050 |
Asthma | 27.77 | 10.73 | 21 | 62630 | 36153 | 29853674 |
Dystonia | 27.44 | 10.73 | 62 | 62589 | 9665 | 29880162 |
Product prescribing error | 27.24 | 10.73 | 87 | 62564 | 16646 | 29873181 |
Infusion related reaction | 26.96 | 10.73 | 27 | 62624 | 40537 | 29849290 |
Macrophages increased | 26.86 | 10.73 | 11 | 62640 | 163 | 29889664 |
Catatonia | 26.66 | 10.73 | 39 | 62612 | 4341 | 29885486 |
Altered state of consciousness | 26.66 | 10.73 | 97 | 62554 | 19822 | 29870005 |
Diarrhoea | 26.60 | 10.73 | 516 | 62135 | 333587 | 29556240 |
Pleural effusion | 26.30 | 10.73 | 74 | 62577 | 73992 | 29815835 |
Hyperreflexia | 26.17 | 10.73 | 31 | 62620 | 2808 | 29887019 |
Hallucinations, mixed | 26.07 | 10.73 | 29 | 62622 | 2454 | 29887373 |
Depressive symptom | 26.06 | 10.73 | 24 | 62627 | 1621 | 29888206 |
Product prescribing issue | 25.78 | 10.73 | 18 | 62633 | 815 | 29889012 |
Dysgraphia | 25.55 | 10.73 | 23 | 62628 | 1508 | 29888319 |
Benign gastrointestinal neoplasm | 25.33 | 10.73 | 10 | 62641 | 134 | 29889693 |
Cytomegalovirus infection | 25.19 | 10.73 | 9 | 62642 | 23665 | 29866162 |
Alcohol use | 25.16 | 10.73 | 35 | 62616 | 3720 | 29886107 |
Sarcopenia | 25.07 | 10.73 | 12 | 62639 | 262 | 29889565 |
Bipolar disorder | 25.01 | 10.73 | 35 | 62616 | 3741 | 29886086 |
Thrombocytopenia | 24.90 | 10.73 | 176 | 62475 | 136868 | 29752959 |
Urticaria | 24.64 | 10.73 | 48 | 62603 | 54558 | 29835269 |
Stomatitis | 24.56 | 10.73 | 25 | 62626 | 37254 | 29852573 |
Congenital cerebrovascular anomaly | 24.47 | 10.73 | 6 | 62645 | 12 | 29889815 |
Respiratory disorder neonatal | 24.20 | 10.73 | 20 | 62631 | 1168 | 29888659 |
Feeling guilty | 23.89 | 10.73 | 12 | 62639 | 292 | 29889535 |
Renal impairment | 23.77 | 10.73 | 93 | 62558 | 84091 | 29805736 |
Aptyalism | 23.59 | 10.73 | 11 | 62640 | 226 | 29889601 |
Herpes zoster | 23.48 | 10.73 | 17 | 62634 | 29926 | 29859901 |
Feeling jittery | 23.04 | 10.73 | 34 | 62617 | 3814 | 29886013 |
Bradykinesia | 22.99 | 10.73 | 31 | 62620 | 3199 | 29886628 |
Pulmonary congestion | 22.91 | 10.73 | 67 | 62584 | 12220 | 29877607 |
Cogwheel rigidity | 22.88 | 10.73 | 19 | 62632 | 1117 | 29888710 |
Slow speech | 22.87 | 10.73 | 18 | 62633 | 980 | 29888847 |
IVth nerve disorder | 22.75 | 10.73 | 6 | 62645 | 18 | 29889809 |
Mood altered | 22.63 | 10.73 | 52 | 62599 | 8198 | 29881629 |
Drug hypersensitivity | 22.49 | 10.73 | 71 | 62580 | 68448 | 29821379 |
Arthralgia | 22.48 | 10.73 | 179 | 62472 | 135612 | 29754215 |
Pressure of speech | 22.29 | 10.73 | 13 | 62638 | 429 | 29889398 |
Ataxia | 21.85 | 10.73 | 63 | 62588 | 11399 | 29878428 |
Acute psychosis | 21.60 | 10.73 | 23 | 62628 | 1853 | 29887974 |
Erythema | 21.59 | 10.73 | 86 | 62565 | 77365 | 29812462 |
Vestibular disorder | 21.57 | 10.73 | 16 | 62635 | 797 | 29889030 |
Parkinsonian gait | 21.53 | 10.73 | 13 | 62638 | 458 | 29889369 |
Injection site pain | 21.52 | 10.73 | 19 | 62632 | 30291 | 29859536 |
Acute kidney injury | 21.44 | 10.73 | 424 | 62227 | 273418 | 29616409 |
Perforated ulcer | 21.41 | 10.73 | 9 | 62642 | 143 | 29889684 |
Irritability | 21.19 | 10.73 | 100 | 62551 | 22950 | 29866877 |
Decreased gait velocity | 21.06 | 10.73 | 8 | 62643 | 96 | 29889731 |
Acute myocardial infarction | 21.01 | 10.73 | 50 | 62601 | 52889 | 29836938 |
Helplessness | 20.94 | 10.73 | 7 | 62644 | 56 | 29889771 |
Sepsis | 20.69 | 10.73 | 201 | 62450 | 146194 | 29743633 |
Psychomotor skills impaired | 20.59 | 10.73 | 23 | 62628 | 1956 | 29887871 |
Activation syndrome | 20.55 | 10.73 | 8 | 62643 | 103 | 29889724 |
Temperature regulation disorder | 20.53 | 10.73 | 13 | 62638 | 499 | 29889328 |
Dysarthria | 20.29 | 10.73 | 121 | 62530 | 30369 | 29859458 |
Depersonalisation/derealisation disorder | 20.18 | 10.73 | 13 | 62638 | 514 | 29889313 |
Sinusitis | 20.16 | 10.73 | 24 | 62627 | 33321 | 29856506 |
Substance abuse | 20.00 | 10.73 | 45 | 62606 | 6995 | 29882832 |
Hanging | 19.88 | 10.73 | 8 | 62643 | 113 | 29889714 |
Bezoar | 19.83 | 10.73 | 16 | 62635 | 903 | 29888924 |
Hypertonia | 19.72 | 10.73 | 34 | 62617 | 4351 | 29885476 |
Dyspnoea | 19.67 | 10.73 | 539 | 62112 | 332756 | 29557071 |
Rebound effect | 19.52 | 10.73 | 20 | 62631 | 1541 | 29888286 |
Loss of proprioception | 19.48 | 10.73 | 10 | 62641 | 255 | 29889572 |
Mucosal inflammation | 19.47 | 10.73 | 21 | 62630 | 30473 | 29859354 |
Verbal abuse | 19.34 | 10.73 | 9 | 62642 | 184 | 29889643 |
Dementia with Lewy bodies | 19.05 | 10.73 | 13 | 62638 | 567 | 29889260 |
Suspected suicide | 19.03 | 10.73 | 28 | 62623 | 3133 | 29886694 |
Blood ethanol increased | 19.00 | 10.73 | 11 | 62640 | 358 | 29889469 |
Arachnoid cyst | 18.14 | 10.73 | 9 | 62642 | 213 | 29889614 |
Metabolic syndrome | 18.13 | 10.73 | 19 | 62632 | 1503 | 29888324 |
Homicide | 18.02 | 10.73 | 16 | 62635 | 1030 | 29888797 |
Hypervigilance | 17.87 | 10.73 | 8 | 62643 | 149 | 29889678 |
Cardiac failure | 17.77 | 10.73 | 102 | 62549 | 83316 | 29806511 |
Blood creatinine increased | 17.75 | 10.73 | 115 | 62536 | 91260 | 29798567 |
Seizure | 17.74 | 10.73 | 297 | 62354 | 98178 | 29791649 |
Renal disorder | 17.71 | 10.73 | 14 | 62637 | 23570 | 29866257 |
Arthritis | 17.68 | 10.73 | 15 | 62636 | 24386 | 29865441 |
Hangover | 17.61 | 10.73 | 16 | 62635 | 1062 | 29888765 |
Antipsychotic drug level increased | 17.57 | 10.73 | 27 | 62624 | 3139 | 29886688 |
Ejaculation failure | 17.45 | 10.73 | 14 | 62637 | 784 | 29889043 |
Circulatory collapse | 17.36 | 10.73 | 86 | 62565 | 20128 | 29869699 |
Drug ineffective | 17.22 | 10.73 | 562 | 62089 | 339825 | 29550002 |
Loose associations | 17.14 | 10.73 | 6 | 62645 | 56 | 29889771 |
Eosinophilic myocarditis | 17.05 | 10.73 | 11 | 62640 | 436 | 29889391 |
Amnestic disorder | 17.04 | 10.73 | 8 | 62643 | 167 | 29889660 |
Respiratory rate decreased | 17.03 | 10.73 | 20 | 62631 | 1795 | 29888032 |
Myelodysplastic syndrome | 17.02 | 10.73 | 9 | 62642 | 18769 | 29871058 |
Implant site extravasation | 17.01 | 10.73 | 11 | 62640 | 438 | 29889389 |
Peritonitis | 16.94 | 10.73 | 12 | 62639 | 21363 | 29868464 |
Peripheral swelling | 16.90 | 10.73 | 68 | 62583 | 61006 | 29828821 |
Septic shock | 16.87 | 10.73 | 72 | 62579 | 63535 | 29826292 |
Chest pain | 16.82 | 10.73 | 161 | 62490 | 117466 | 29772361 |
Osteonecrosis of jaw | 16.77 | 10.73 | 9 | 62642 | 18609 | 29871218 |
Psychiatric decompensation | 16.72 | 10.73 | 17 | 62634 | 1298 | 29888529 |
Balance disorder | 16.66 | 10.73 | 132 | 62519 | 36361 | 29853466 |
Sexual dysfunction | 16.65 | 10.73 | 38 | 62613 | 5963 | 29883864 |
Ejaculation disorder | 16.64 | 10.73 | 15 | 62636 | 985 | 29888842 |
Neonatal respiratory distress syndrome | 16.61 | 10.73 | 30 | 62621 | 3982 | 29885845 |
Hepatic steatosis | 16.50 | 10.73 | 68 | 62583 | 14725 | 29875102 |
Urine sodium decreased | 16.34 | 10.73 | 8 | 62643 | 184 | 29889643 |
Respiratory tract infection | 16.32 | 10.73 | 6 | 62645 | 15500 | 29874327 |
Oesophageal haemorrhage | 16.28 | 10.73 | 16 | 62635 | 1172 | 29888655 |
Postoperative respiratory failure | 16.10 | 10.73 | 6 | 62645 | 68 | 29889759 |
Alcoholism | 16.05 | 10.73 | 27 | 62624 | 3387 | 29886440 |
Feelings of worthlessness | 15.84 | 10.73 | 8 | 62643 | 197 | 29889630 |
Soft tissue mass | 15.74 | 10.73 | 9 | 62642 | 286 | 29889541 |
Psychomotor retardation | 15.68 | 10.73 | 22 | 62629 | 2357 | 29887470 |
Tubulointerstitial nephritis | 15.60 | 10.73 | 9 | 62642 | 17882 | 29871945 |
Haemoglobin decreased | 15.55 | 10.73 | 158 | 62493 | 113940 | 29775887 |
Hyperbilirubinaemia | 15.54 | 10.73 | 8 | 62643 | 16934 | 29872893 |
Erectile dysfunction | 15.53 | 10.73 | 77 | 62574 | 18025 | 29871802 |
Rapid eye movements sleep abnormal | 15.48 | 10.73 | 8 | 62643 | 207 | 29889620 |
Nervousness | 15.43 | 10.73 | 57 | 62594 | 11731 | 29878096 |
Off label use | 15.24 | 10.73 | 401 | 62250 | 248889 | 29640938 |
Intentional product misuse | 15.06 | 10.73 | 124 | 62527 | 34543 | 29855284 |
Self esteem decreased | 15.06 | 10.73 | 11 | 62640 | 535 | 29889292 |
Sleep deficit | 15.05 | 10.73 | 10 | 62641 | 417 | 29889410 |
Eosinophilic pleural effusion | 15.04 | 10.73 | 8 | 62643 | 220 | 29889607 |
Posture abnormal | 14.99 | 10.73 | 19 | 62632 | 1845 | 29887982 |
Cellulitis | 14.98 | 10.73 | 49 | 62602 | 46735 | 29843092 |
Tricuspid valve sclerosis | 14.96 | 10.73 | 5 | 62646 | 40 | 29889787 |
Speech disorder | 14.88 | 10.73 | 95 | 62556 | 24417 | 29865410 |
Urinary hesitation | 14.87 | 10.73 | 21 | 62630 | 2263 | 29887564 |
Drug withdrawal syndrome neonatal | 14.78 | 10.73 | 25 | 62626 | 3150 | 29886677 |
Fear of disease | 14.78 | 10.73 | 8 | 62643 | 228 | 29889599 |
Insulin resistance | 14.77 | 10.73 | 11 | 62640 | 551 | 29889276 |
Gait disturbance | 14.76 | 10.73 | 229 | 62422 | 74548 | 29815279 |
Stupor | 14.75 | 10.73 | 24 | 62627 | 2929 | 29886898 |
Anger | 14.75 | 10.73 | 54 | 62597 | 11066 | 29878761 |
Drug reaction with eosinophilia and systemic symptoms | 14.70 | 10.73 | 23 | 62628 | 28465 | 29861362 |
Gout | 14.69 | 10.73 | 9 | 62642 | 17306 | 29872521 |
Asphyxia | 14.66 | 10.73 | 34 | 62617 | 5391 | 29884436 |
Neonatal hyponatraemia | 14.65 | 10.73 | 6 | 62645 | 89 | 29889738 |
Mood swings | 14.62 | 10.73 | 42 | 62609 | 7584 | 29882243 |
Pancytopenia | 14.58 | 10.73 | 111 | 62540 | 84941 | 29804886 |
Fear of weight gain | 14.49 | 10.73 | 4 | 62647 | 15 | 29889812 |
Xanthoma | 14.47 | 10.73 | 6 | 62645 | 92 | 29889735 |
Acute myeloid leukaemia | 14.41 | 10.73 | 10 | 62641 | 17996 | 29871831 |
Upper respiratory tract infection | 14.36 | 10.73 | 22 | 62629 | 27454 | 29862373 |
Bronchopulmonary aspergillosis | 14.26 | 10.73 | 4 | 62647 | 12280 | 29877547 |
Sudden cardiac death | 14.21 | 10.73 | 27 | 62624 | 3725 | 29886102 |
Body temperature abnormal | 14.18 | 10.73 | 10 | 62641 | 460 | 29889367 |
Failure to thrive | 14.15 | 10.73 | 43 | 62608 | 8011 | 29881816 |
Pyroglutamic acidosis | 14.07 | 10.73 | 6 | 62645 | 99 | 29889728 |
Sinus bradycardia | 14.03 | 10.73 | 55 | 62596 | 11640 | 29878187 |
JC virus infection | 14.01 | 10.73 | 18 | 62633 | 1772 | 29888055 |
Sepsis neonatal | 14.00 | 10.73 | 8 | 62643 | 254 | 29889573 |
Psoriasis | 13.97 | 10.73 | 44 | 62607 | 42462 | 29847365 |
Pelvic fracture | 13.93 | 10.73 | 20 | 62631 | 2188 | 29887639 |
Non-alcoholic steatohepatitis | 13.89 | 10.73 | 12 | 62639 | 745 | 29889082 |
Pulmonary fibrosis | 13.85 | 10.73 | 8 | 62643 | 15882 | 29873945 |
Locked-in syndrome | 13.83 | 10.73 | 8 | 62643 | 260 | 29889567 |
Dry skin | 13.75 | 10.73 | 16 | 62635 | 22438 | 29867389 |
White blood cell count decreased | 13.72 | 10.73 | 111 | 62540 | 83836 | 29805991 |
Mumps | 13.69 | 10.73 | 6 | 62645 | 106 | 29889721 |
Palmar-plantar erythrodysaesthesia syndrome | 13.67 | 10.73 | 7 | 62644 | 14863 | 29874964 |
Wrong product administered | 13.66 | 10.73 | 30 | 62621 | 4588 | 29885239 |
Neutropenia | 13.66 | 10.73 | 188 | 62463 | 128352 | 29761475 |
Tumour lysis syndrome | 13.53 | 10.73 | 5 | 62646 | 12880 | 29876947 |
Malignant neoplasm progression | 13.52 | 10.73 | 92 | 62559 | 72195 | 29817632 |
Obsessive-compulsive disorder | 13.52 | 10.73 | 28 | 62623 | 4113 | 29885714 |
Polypectomy | 13.34 | 10.73 | 10 | 62641 | 506 | 29889321 |
Cryptorchism | 13.34 | 10.73 | 17 | 62634 | 1660 | 29888167 |
Hyporesponsive to stimuli | 13.27 | 10.73 | 13 | 62638 | 949 | 29888878 |
Spinal cord injury thoracic | 13.20 | 10.73 | 6 | 62645 | 116 | 29889711 |
Back pain | 13.19 | 10.73 | 144 | 62507 | 102452 | 29787375 |
Mastication disorder | 13.15 | 10.73 | 14 | 62637 | 1128 | 29888699 |
Sensory disturbance | 13.13 | 10.73 | 34 | 62617 | 5777 | 29884050 |
Housebound | 13.11 | 10.73 | 7 | 62644 | 194 | 29889633 |
Acute pulmonary oedema | 13.08 | 10.73 | 40 | 62611 | 7475 | 29882352 |
Hypotonia | 13.06 | 10.73 | 38 | 62613 | 6910 | 29882917 |
Pneumocystis jirovecii pneumonia | 13.06 | 10.73 | 10 | 62641 | 17110 | 29872717 |
Consciousness fluctuating | 12.98 | 10.73 | 13 | 62638 | 975 | 29888852 |
Alcohol poisoning | 12.94 | 10.73 | 26 | 62625 | 3738 | 29886089 |
Dementia | 12.90 | 10.73 | 56 | 62595 | 12405 | 29877422 |
Electrocardiogram QRS complex prolonged | 12.90 | 10.73 | 28 | 62623 | 4249 | 29885578 |
Nephrolithiasis | 12.83 | 10.73 | 20 | 62631 | 24790 | 29865037 |
Basal cell carcinoma | 12.76 | 10.73 | 9 | 62642 | 16059 | 29873768 |
Social avoidant behaviour | 12.62 | 10.73 | 22 | 62629 | 2841 | 29886986 |
Hypersomnia | 12.60 | 10.73 | 52 | 62599 | 11264 | 29878563 |
Mitral valve sclerosis | 12.58 | 10.73 | 6 | 62645 | 130 | 29889697 |
Dysaesthesia | 12.54 | 10.73 | 19 | 62632 | 2182 | 29887645 |
Limited symptom panic attack | 12.53 | 10.73 | 5 | 62646 | 69 | 29889758 |
Nasal discomfort | 12.47 | 10.73 | 14 | 62637 | 1197 | 29888630 |
Incoherent | 12.46 | 10.73 | 27 | 62624 | 4091 | 29885736 |
Abdominal discomfort | 12.46 | 10.73 | 56 | 62595 | 48735 | 29841092 |
Diabetes insipidus | 12.29 | 10.73 | 19 | 62632 | 2220 | 29887607 |
Homicidal ideation | 12.28 | 10.73 | 20 | 62631 | 2443 | 29887384 |
Blood pressure increased | 12.26 | 10.73 | 94 | 62557 | 71834 | 29817993 |
Epilepsy | 12.14 | 10.73 | 78 | 62573 | 20091 | 29869736 |
Mutism | 12.07 | 10.73 | 11 | 62640 | 733 | 29889094 |
Small for dates baby | 12.05 | 10.73 | 23 | 62628 | 3185 | 29886642 |
Cold sweat | 11.96 | 10.73 | 44 | 62607 | 9038 | 29880789 |
Impaired driving ability | 11.96 | 10.73 | 20 | 62631 | 2498 | 29887329 |
Sinus tachycardia | 11.95 | 10.73 | 64 | 62587 | 15440 | 29874387 |
Agitated depression | 11.92 | 10.73 | 7 | 62644 | 234 | 29889593 |
Electric shock | 11.87 | 10.73 | 6 | 62645 | 148 | 29889679 |
Implant site infection | 11.79 | 10.73 | 12 | 62639 | 917 | 29888910 |
Intentional product use issue | 11.78 | 10.73 | 38 | 62613 | 36402 | 29853425 |
Inappropriate schedule of product administration | 11.78 | 10.73 | 43 | 62608 | 39685 | 29850142 |
Kidney congestion | 11.76 | 10.73 | 7 | 62644 | 240 | 29889587 |
Rash erythematous | 11.71 | 10.73 | 18 | 62633 | 22434 | 29867393 |
Contraindication to medical treatment | 11.66 | 10.73 | 9 | 62642 | 476 | 29889351 |
Inferior vena caval occlusion | 11.65 | 10.73 | 4 | 62647 | 35 | 29889792 |
Nasal congestion | 11.61 | 10.73 | 13 | 62638 | 18553 | 29871274 |
Suprapubic pain | 11.60 | 10.73 | 8 | 62643 | 355 | 29889472 |
Intentional device misuse | 11.58 | 10.73 | 7 | 62644 | 247 | 29889580 |
Plasma cell myeloma | 11.58 | 10.73 | 65 | 62586 | 53397 | 29836430 |
Bladder dilatation | 11.56 | 10.73 | 14 | 62637 | 1298 | 29888529 |
Toxic encephalopathy | 11.50 | 10.73 | 28 | 62623 | 4581 | 29885246 |
Formication | 11.50 | 10.73 | 16 | 62635 | 1701 | 29888126 |
Lung disorder | 11.49 | 10.73 | 31 | 62620 | 31438 | 29858389 |
Dysphoria | 11.48 | 10.73 | 18 | 62633 | 2130 | 29887697 |
Splenomegaly | 11.45 | 10.73 | 7 | 62644 | 13473 | 29876354 |
Blood urea increased | 11.39 | 10.73 | 31 | 62620 | 31350 | 29858477 |
Respiratory depression | 11.38 | 10.73 | 51 | 62600 | 11452 | 29878375 |
Fluid retention | 11.25 | 10.73 | 22 | 62629 | 24976 | 29864851 |
Cerebellar ataxia | 11.22 | 10.73 | 12 | 62639 | 972 | 29888855 |
Head discomfort | 11.20 | 10.73 | 21 | 62630 | 2869 | 29886958 |
Cerebrovascular accident | 11.20 | 10.73 | 116 | 62535 | 83361 | 29806466 |
Pseudomonas infection | 11.12 | 10.73 | 4 | 62647 | 10478 | 29879349 |
Jealous delusion | 11.12 | 10.73 | 7 | 62644 | 266 | 29889561 |
Panic disorder | 11.11 | 10.73 | 13 | 62638 | 1162 | 29888665 |
Suspiciousness | 11.10 | 10.73 | 8 | 62643 | 381 | 29889446 |
Pharyngitis bacterial | 11.09 | 10.73 | 4 | 62647 | 41 | 29889786 |
Flatulence | 11.01 | 10.73 | 13 | 62638 | 18116 | 29871711 |
Respiratory acidosis | 10.99 | 10.73 | 26 | 62625 | 4176 | 29885651 |
Thrombotic stroke | 10.93 | 10.73 | 7 | 62644 | 274 | 29889553 |
Hyperthermia | 10.93 | 10.73 | 46 | 62605 | 10053 | 29879774 |
Hypertrophic scar | 10.92 | 10.73 | 3 | 62648 | 11 | 29889816 |
Thinking abnormal | 10.92 | 10.73 | 30 | 62621 | 5281 | 29884546 |
Staphylococcal infection | 10.87 | 10.73 | 30 | 62621 | 30194 | 29859633 |
Prostate cancer | 10.85 | 10.73 | 21 | 62630 | 23936 | 29865891 |
JC virus CSF test positive | 10.85 | 10.73 | 5 | 62646 | 100 | 29889727 |
Pneumonitis | 10.83 | 10.73 | 26 | 62625 | 27428 | 29862399 |
Agitation neonatal | 10.81 | 10.73 | 12 | 62639 | 1013 | 29888814 |
Hepatic function abnormal | 10.80 | 10.73 | 48 | 62603 | 41897 | 29847930 |
Joint swelling | 10.76 | 10.73 | 56 | 62595 | 46890 | 29842937 |
Porphyria acute | 10.76 | 10.73 | 5 | 62646 | 102 | 29889725 |
Source | Code | Description |
---|---|---|
ATC | N06AX11 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Other antidepressants |
MeSH PA | D018663 | Adrenergic Agents |
MeSH PA | D058669 | Adrenergic alpha-2 Receptor Antagonists |
MeSH PA | D000317 | Adrenergic alpha-Antagonists |
MeSH PA | D018674 | Adrenergic Antagonists |
MeSH PA | D014151 | Anti-Anxiety Agents |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D018494 | Histamine Agents |
MeSH PA | D006633 | Histamine Antagonists |
MeSH PA | D006634 | Histamine H1 Antagonists |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D058830 | Serotonin 5-HT2 Receptor Antagonists |
MeSH PA | D058831 | Serotonin 5-HT3 Receptor Antagonists |
MeSH PA | D018490 | Serotonin Agents |
MeSH PA | D012702 | Serotonin Antagonists |
MeSH PA | D014149 | Tranquilizing Agents |
CHEBI has role | CHEBI:35474 | minor tranquilisers |
CHEBI has role | CHEBI:37890 | alpha-adrenoceptor antagonists |
CHEBI has role | CHEBI:37955 | h1-receptor blockers |
CHEBI has role | CHEBI:37956 | histamine receptor blocker |
CHEBI has role | CHEBI:48279 | serotonin antagonists |
CHEBI has role | CHEBI:146270 | oneirogens |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Major depressive disorder | indication | 370143000 | |
Excessive vomiting in pregnancy | off-label use | 14094001 | |
Posttraumatic stress disorder | off-label use | 47505003 | DOID:2055 |
Suicidal thoughts | contraindication | 6471006 | |
Weight gain finding | contraindication | 8943002 | |
Hypercholesterolemia | contraindication | 13644009 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Hypovolemia | contraindication | 28560003 | |
Orthostatic hypotension | contraindication | 28651003 | |
Dehydration | contraindication | 34095006 | |
Low blood pressure | contraindication | 45007003 | |
Cerebrovascular disease | contraindication | 62914000 | DOID:6713 |
Hyponatremia | contraindication | 89627008 | |
Seizure disorder | contraindication | 128613002 | |
Liver function tests abnormal | contraindication | 166603001 | |
Bipolar affective disorder, current episode manic | contraindication | 191618007 | |
Angina pectoris | contraindication | 194828000 | |
Impaired renal function disorder | contraindication | 197663003 | |
Cerebrovascular accident | contraindication | 230690007 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Akathisia | contraindication | 285145004 | |
Hypertriglyceridemia | contraindication | 302870006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Serotonin syndrome | contraindication | 371089000 | |
Obesity | contraindication | 414916001 | DOID:9970 |
Acute Thromboembolic Stroke | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.67 | Basic |
pKa2 | 2.91 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 2A | GPCR | ANTAGONIST | Ki | 7.16 | CHEMBL | CHEMBL | |||
5-hydroxytryptamine receptor 2C | GPCR | ANTAGONIST | Ki | 7.41 | CHEMBL | CHEMBL | |||
D(3) dopamine receptor | GPCR | Ki | 5.24 | CHEMBL | |||||
5-hydroxytryptamine receptor 7 | GPCR | Ki | 6.58 | CHEMBL | |||||
Alpha-2B adrenergic receptor | GPCR | ANTAGONIST | IC50 | 6.65 | CHEMBL | ||||
Alpha-2C adrenergic receptor | GPCR | ANTAGONIST | Ki | 7.74 | CHEMBL | ||||
5-hydroxytryptamine receptor 3A | Ion channel | Ki | 5.54 | CHEMBL | |||||
5-hydroxytryptamine receptor 1A | GPCR | Kd | 5.30 | CHEMBL | |||||
Alpha-1A adrenergic receptor | GPCR | IC50 | 5.50 | CHEMBL | |||||
Muscarinic acetylcholine receptor M2 | GPCR | WOMBAT-PK | |||||||
Muscarinic acetylcholine receptor M1 | GPCR | WOMBAT-PK | |||||||
Histamine H1 receptor | GPCR | Ki | 8.80 | WOMBAT-PK | |||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 5.34 | PDSP | |||||
D(1A) dopamine receptor | GPCR | Ki | 5.38 | PDSP | |||||
D(2) dopamine receptor | GPCR | Ki | 5.26 | PDSP | |||||
Alpha-2A adrenergic receptor | GPCR | ANTAGONIST | Ki | 7.70 | CHEMBL | ||||
D(1A) dopamine receptor | GPCR | Ki | 5.38 | CHEMBL | |||||
D(2) dopamine receptor | GPCR | Ki | 5.84 | CHEMBL | |||||
Transporter | Transporter | Ki | 5.79 | CHEMBL | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 8.26 | CHEMBL | |||||
Adrenergic receptor alpha-1 | GPCR | Ki | 6.22 | CHEMBL | |||||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 8.70 | CHEMBL |
ID | Source |
---|---|
4020978 | VUID |
N0000148449 | NUI |
D00563 | KEGG_DRUG |
4020978 | VANDF |
C0049506 | UMLSCUI |
CHEBI:6950 | CHEBI |
CHEMBL654 | ChEMBL_ID |
D000078785 | MESH_DESCRIPTOR_UI |
DB00370 | DRUGBANK_ID |
7241 | IUPHAR_LIGAND_ID |
6481 | INN_ID |
A051Q2099Q | UNII |
4205 | PUBCHEM_CID |
15996 | RXNORM |
46110 | MMSL |
5120 | MMSL |
d04025 | MMSL |
006054 | NDDF |
108430001 | SNOMEDCT_US |
386847004 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
REMERON | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-0105 | TABLET, FILM COATED | 15 mg | ORAL | NDA | 31 sections |
REMERONSOLTAB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-0106 | TABLET, ORALLY DISINTEGRATING | 15 mg | ORAL | NDA | 31 sections |
REMERON | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-0107 | TABLET, FILM COATED | 30 mg | ORAL | NDA | 31 sections |
REMERONSOLTAB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-0108 | TABLET, ORALLY DISINTEGRATING | 30 mg | ORAL | NDA | 31 sections |
REMERON | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-0109 | TABLET, FILM COATED | 45 mg | ORAL | NDA | 31 sections |
REMERONSOLTAB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-0110 | TABLET, ORALLY DISINTEGRATING | 45 mg | ORAL | NDA | 31 sections |
REMERON | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-4364 | TABLET, FILM COATED | 15 mg | ORAL | NDA | 31 sections |
REMERON | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-4365 | TABLET, FILM COATED | 30 mg | ORAL | NDA | 31 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3515 | TABLET, FILM COATED | 15 mg | ORAL | ANDA | 28 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3530 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 28 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3545 | TABLET, FILM COATED | 45 mg | ORAL | ANDA | 28 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8078 | TABLET | 7.50 mg | ORAL | ANDA | 25 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8268 | TABLET, FILM COATED | 15 mg | ORAL | ANDA | 25 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8269 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 25 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6519 | TABLET, FILM COATED | 15 mg | ORAL | ANDA | 24 sections |
Mirtazapine | Human Prescription Drug Label | 1 | 13107-001 | TABLET, FILM COATED | 7.50 mg | ORAL | ANDA | 25 sections |
Mirtazapine | Human Prescription Drug Label | 1 | 13107-003 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 25 sections |
Mirtazapine | Human Prescription Drug Label | 1 | 13107-031 | TABLET, FILM COATED | 15 mg | ORAL | ANDA | 25 sections |
Mirtazapine | Human Prescription Drug Label | 1 | 13107-032 | TABLET, FILM COATED | 45 mg | ORAL | ANDA | 25 sections |
MIRTAZAPINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-153 | TABLET, FILM COATED | 15 mg | ORAL | ANDA | 26 sections |
MIRTAZAPINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-154 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 26 sections |
MIRTAZAPINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-155 | TABLET, FILM COATED | 45 mg | ORAL | ANDA | 26 sections |
Mirtazapine | Human Prescription Drug Label | 1 | 17856-0101 | TABLET, FILM COATED | 7.50 mg | ORAL | ANDA | 25 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-081 | TABLET, FILM COATED | 15 mg | ORAL | ANDA | 29 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-082 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 29 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-083 | TABLET, FILM COATED | 45 mg | ORAL | ANDA | 29 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-073 | TABLET, FILM COATED | 15 mg | ORAL | ANDA | 25 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-074 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 26 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-086 | TABLET, FILM COATED | 15 mg | ORAL | ANDA | 26 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-087 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 26 sections |