mirtazapine 🐢 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
psychoactive 1816 85650-52-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mirtazapine
  • mepirzapin
  • mepirzepine
  • mirtabene
  • mirtazepine
  • mirtazipine
A piperazinoazepine tetracyclic compound that enhances the release of NOREPINEPHRINE and SEROTONIN through blockage of presynaptic ALPHA-2 ADRENERGIC RECEPTORS. It also blocks both 5-HT2 and 5-HT3 serotonin receptors and is a potent HISTAMINE H1 RECEPTOR antagonist. It is used for the treatment of depression, and may also be useful for the treatment of anxiety disorders.
  • Molecular weight: 265.36
  • Formula: C17H19N3
  • CLOGP: 3.07
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 19.37
  • ALOGS: -2.38
  • ROTB: 0

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
30 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 2 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.83 Β΅M/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 4.20 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 8 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.15 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 15 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
June 14, 1996 FDA ORGANON USA INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Intentional overdose 786.99 10.00 795 104990 67322 56118960
Drug abuse 584.15 10.00 677 105108 66933 56119349
Serotonin syndrome 582.47 10.00 446 105339 26044 56160238
Suicide attempt 573.00 10.00 622 105163 57214 56129068
Intentional self-injury 554.37 10.00 423 105362 24569 56161713
Toxicity to various agents 535.91 10.00 1253 104532 223311 55962971
Rheumatoid arthritis 476.44 10.00 75 105710 382529 55803753
Sopor 454.97 10.00 350 105435 20572 56165710
Completed suicide 412.89 10.00 829 104956 133004 56053278
Suicidal ideation 390.09 10.00 511 105274 57231 56129051
Drug interaction 377.92 10.00 1053 104732 208702 55977580
Electrocardiogram QT prolonged 371.71 10.00 485 105300 54103 56132179
Hyponatraemia 329.69 10.00 645 105140 101494 56084788
Overdose 312.52 10.00 644 105141 105186 56081096
Somnolence 299.66 10.00 826 104959 162587 56023695
Agitation 279.38 10.00 429 105356 55607 56130675
Systemic lupus erythematosus 268.08 10.00 18 105767 180060 56006222
Joint swelling 259.54 10.00 110 105675 289690 55896592
Pemphigus 258.96 10.00 8 105777 157204 56029078
Arthropathy 240.61 10.00 43 105742 200232 55986050
Infusion related reaction 228.10 10.00 56 105729 208875 55977407
Glossodynia 219.03 10.00 18 105767 152440 56033842
Treatment failure 210.34 10.00 34 105751 170358 56015924
Tremor 207.03 10.00 597 105188 120492 56065790
Depression 206.40 10.00 775 105010 179342 56006940
Restlessness 205.94 10.00 252 105533 26334 56159948
Depressed level of consciousness 201.24 10.00 372 105413 56061 56130221
Rash 199.57 10.00 391 105394 492656 55693626
Drug ineffective 197.87 10.00 974 104811 918015 55268267
Alopecia 196.71 10.00 158 105627 293300 55892982
Contraindicated product administered 193.69 10.00 55 105730 186231 56000051
Disorientation 193.36 10.00 288 105497 36325 56149957
Neuroleptic malignant syndrome 190.35 10.00 164 105621 11314 56174968
Swelling 187.44 10.00 109 105676 239662 55946620
Synovitis 186.55 10.00 38 105747 161267 56025015
Tachycardia 185.81 10.00 527 105258 105349 56080933
Muscle rigidity 184.17 10.00 156 105629 10515 56175767
Inappropriate antidiuretic hormone secretion 181.82 10.00 173 105612 13583 56172699
Coma 172.40 10.00 360 105425 59295 56126987
Fall 171.59 10.00 1204 104581 356306 55829976
Sinusitis 170.45 10.00 79 105706 197502 55988780
Abdominal discomfort 170.41 10.00 162 105623 277112 55909170
Confusional state 170.14 10.00 808 104977 207347 55978935
Anxiety 166.80 10.00 762 105023 192410 55993872
Disturbance in attention 163.35 10.00 250 105535 32290 56153992
Dissociation 160.31 10.00 84 105701 2501 56183781
Therapeutic product effect decreased 153.67 10.00 63 105722 169389 56016893
Akathisia 152.43 10.00 128 105657 8524 56177758
Pain 151.00 10.00 688 105097 662496 55523786
Depersonalisation/derealisation disorder 148.47 10.00 64 105721 1215 56185067
Drug intolerance 146.64 10.00 169 105616 264649 55921633
Pericarditis 138.34 10.00 20 105765 108903 56077379
Dyskinesia 138.24 10.00 218 105567 28890 56157392
Nasopharyngitis 138.17 10.00 127 105658 220832 55965450
Hypersensitivity 137.30 10.00 168 105617 256240 55930042
Mydriasis 132.75 10.00 132 105653 10939 56175343
Restless legs syndrome 130.20 10.00 160 105625 16787 56169495
Depressed mood 127.48 10.00 238 105547 36121 56150161
Gastric pH decreased 126.39 10.00 48 105737 646 56185636
Nightmare 123.09 10.00 155 105630 16671 56169611
Arthralgia 122.79 10.00 506 105279 501163 55685119
Derealisation 118.65 10.00 52 105733 1029 56185253
Peripheral swelling 117.20 10.00 162 105623 234564 55951718
Helicobacter infection 116.19 10.00 5 105780 73263 56113019
Discomfort 115.68 10.00 61 105724 141700 56044582
Duodenal ulcer perforation 114.23 10.00 3 105782 68339 56117943
Urinary retention 112.78 10.00 195 105590 27879 56158403
Drug withdrawal syndrome 111.01 10.00 185 105600 25672 56160610
Drug hypersensitivity 110.41 10.00 219 105566 274986 55911296
Aggression 110.34 10.00 169 105616 21837 56164445
Hallucination 110.00 10.00 268 105517 48881 56137401
Feeling of despair 108.56 10.00 61 105724 2092 56184190
Product use issue 105.90 10.00 116 105669 185925 56000357
Mania 105.49 10.00 119 105666 11401 56174881
Dysarthria 105.39 10.00 231 105554 39319 56146963
Hyperhidrosis 103.60 10.00 400 105385 93688 56092594
Cogwheel rigidity 102.37 10.00 56 105729 1821 56184461
Delirium 101.80 10.00 238 105547 42279 56144003
Psoriatic arthropathy 95.34 10.00 13 105772 73995 56112287
Seizure 91.61 10.00 471 105314 124648 56061634
Impaired healing 91.38 10.00 25 105760 86816 56099466
Folliculitis 89.75 10.00 3 105782 54976 56131306
Wound 88.84 10.00 78 105707 138726 56047556
Dystonia 88.60 10.00 113 105672 12308 56173974
Withdrawal syndrome 87.28 10.00 138 105647 18324 56167958
Hallucination, visual 83.17 10.00 131 105654 17337 56168945
Poisoning 82.75 10.00 111 105674 12702 56173580
Psychotic disorder 82.31 10.00 154 105631 23404 56162878
Injection site pain 79.66 10.00 62 105723 117056 56069226
Rheumatoid factor negative 79.56 10.00 33 105752 567 56185715
Urticaria 79.26 10.00 93 105692 144583 56041699
Tardive dyskinesia 77.04 10.00 85 105700 7946 56178336
Parkinsonism 76.37 10.00 92 105693 9454 56176828
H1N1 influenza 75.90 10.00 44 105741 1603 56184679
General physical health deterioration 73.48 10.00 559 105226 169451 56016831
Loss of consciousness 73.44 10.00 402 105383 108947 56077335
Drooling 72.76 10.00 57 105728 3437 56182845
Hepatic enzyme increased 72.50 10.00 132 105653 171252 56015030
Muscle injury 70.60 10.00 8 105777 52492 56133790
Lower respiratory tract infection 69.32 10.00 68 105717 114726 56071556
Blister 68.69 10.00 62 105723 108825 56077457
Myoclonus 68.25 10.00 111 105674 15092 56171190
Irritable bowel syndrome 67.85 10.00 22 105763 68436 56117846
Infection 67.48 10.00 175 105610 200031 55986251
Maternal exposure during pregnancy 64.40 10.00 165 105620 189388 55996894
Hallucination, auditory 64.21 10.00 93 105692 11431 56174851
Speech disorder 64.11 10.00 185 105600 37308 56148974
Pleurothotonus 62.76 10.00 36 105749 1285 56184997
Mood swings 61.68 10.00 112 105673 16635 56169647
Intestinal pseudo-obstruction 61.42 10.00 30 105755 767 56185515
Depressive symptom 59.53 10.00 51 105734 3490 56182792
Incontinence 58.89 10.00 86 105699 10649 56175633
Major depression 58.89 10.00 72 105713 7512 56178770
Knee arthroplasty 58.88 10.00 7 105778 44252 56142030
Parosmia 58.02 10.00 57 105728 4654 56181628
Arthritis 57.06 10.00 62 105723 99790 56086492
Hypertonia 57.01 10.00 53 105732 4039 56182243
Asphyxia 56.79 10.00 62 105723 5727 56180555
C-reactive protein abnormal 56.78 10.00 3 105782 36806 56149476
Sedation 56.74 10.00 169 105616 34685 56151597
Accidental overdose 56.20 10.00 121 105664 20340 56165942
Intentional product use issue 55.81 10.00 63 105722 99670 56086612
Progressive multifocal leukoencephalopathy 55.69 10.00 89 105696 11924 56174358
Pallor 55.43 10.00 133 105652 24016 56162266
Injection site erythema 55.24 10.00 39 105746 77409 56108873
Schizophrenia 54.56 10.00 82 105703 10417 56175865
Feeling jittery 54.14 10.00 88 105697 11958 56174324
Gastrointestinal disorder 53.99 10.00 80 105705 112622 56073660
Hyperkinesia 53.15 10.00 35 105750 1604 56184678
Pruritus 52.88 10.00 363 105422 316260 55870022
Altered state of consciousness 51.99 10.00 126 105659 22895 56163387
Drug dependence 51.61 10.00 124 105661 22409 56163873
Fatigue 51.51 10.00 1111 104674 787441 55398841
Gestational diabetes 50.76 10.00 69 105716 7995 56178287
Neonatal seizure 50.59 10.00 22 105763 427 56185855
Cardiac arrest 50.53 10.00 306 105479 86008 56100274
Psoriasis 50.30 10.00 60 105725 92632 56093650
Injection site pruritus 50.29 10.00 9 105776 41922 56144360
Extrapyramidal disorder 49.84 10.00 86 105699 12270 56174012
Abnormal dreams 49.63 10.00 75 105710 9574 56176708
Headache 48.92 10.00 748 105037 558296 55627986
Impulsive behaviour 48.43 10.00 32 105753 1475 56184807
Feeling of body temperature change 48.28 10.00 51 105734 4538 56181744
Psychomotor retardation 48.20 10.00 46 105739 3623 56182659
Stomatitis 47.62 10.00 97 105688 120713 56065569
Polydipsia 47.21 10.00 43 105742 3192 56183090
Hallucinations, mixed 46.24 10.00 49 105736 4375 56181907
Rhabdomyolysis 45.65 10.00 174 105611 40484 56145798
Decreased appetite 45.61 10.00 620 105165 218611 55967671
Ventricular fibrillation 45.19 10.00 77 105708 10875 56175407
Delusion 45.16 10.00 78 105707 11137 56175145
Poisoning deliberate 45.12 10.00 73 105712 9880 56176402
Circulatory collapse 45.00 10.00 112 105673 20691 56165591
Hip arthroplasty 44.81 10.00 9 105776 38614 56147668
Muscle disorder 44.46 10.00 49 105736 4574 56181708
Cough 43.89 10.00 297 105488 259664 55926618
Therapeutic product ineffective 43.38 10.00 29 105756 1363 56184919
Device expulsion 42.59 10.00 4 105781 30445 56155837
Syncope 42.44 10.00 348 105437 107851 56078431
Hypophagia 42.34 10.00 135 105650 28741 56157541
Menstrual disorder 42.30 10.00 48 105737 4627 56181655
Drug withdrawal syndrome neonatal 42.22 10.00 33 105752 1983 56184299
Acute motor-sensory axonal neuropathy 42.09 10.00 17 105768 272 56186010
Pain in extremity 41.64 10.00 358 105427 297073 55889209
Abnormal behaviour 41.62 10.00 107 105678 20165 56166117
Hypertonia neonatal 41.30 10.00 16 105769 228 56186054
Panic attack 41.03 10.00 107 105678 20340 56165942
Unresponsive to stimuli 40.89 10.00 142 105643 31583 56154699
Chorea 40.63 10.00 28 105757 1384 56184898
Psychomotor hyperactivity 40.47 10.00 69 105716 9751 56176531
Sleep disorder 40.31 10.00 241 105544 67422 56118860
Product dose omission issue 39.71 10.00 224 105561 204529 55981753
Dysphagia 39.69 10.00 277 105508 81670 56104612
Sleep paralysis 39.58 10.00 20 105765 551 56185731
Product administration error 39.44 10.00 107 105678 20822 56165460
Nasal congestion 39.39 10.00 29 105756 56341 56129941
On and off phenomenon 39.35 10.00 29 105756 1595 56184687
Off label use 39.35 10.00 773 105012 555407 55630875
Panic reaction 39.29 10.00 42 105743 3788 56182494
Anger 39.16 10.00 75 105710 11597 56174685
Intentional product misuse 39.13 10.00 196 105589 51308 56134974
Blood prolactin increased 38.83 10.00 39 105746 3270 56183012
Hypoaesthesia oral 37.79 10.00 73 105712 11358 56174924
Ill-defined disorder 37.58 10.00 44 105741 68499 56117783
Bradykinesia 37.56 10.00 46 105739 4808 56181474
Cyanosis 37.28 10.00 88 105697 15722 56170560
Persecutory delusion 37.19 10.00 34 105751 2536 56183746
Product prescribing error 36.39 10.00 111 105674 23075 56163207
Galactorrhoea 35.26 10.00 40 105745 3855 56182427
Generalised tonic-clonic seizure 35.19 10.00 123 105662 27443 56158839
Aphasia 34.83 10.00 131 105654 30284 56155998
Paranoia 34.77 10.00 68 105717 10676 56175606
Asthma 34.66 10.00 103 105682 112667 56073615
Hypokalaemia 34.51 10.00 299 105486 94138 56092144
Irritability 34.35 10.00 128 105657 29460 56156822
Coma scale abnormal 34.30 10.00 44 105741 4819 56181463
Tonic clonic movements 33.79 10.00 24 105761 1246 56185036
Aspiration 33.73 10.00 63 105722 9558 56176724
Opisthotonus 33.32 10.00 15 105770 317 56185965
Injection site bruising 32.25 10.00 16 105769 38505 56147777
Erythema 32.21 10.00 167 105618 155772 56030510
Abulia 31.96 10.00 16 105769 432 56185850
Therapeutic product effect incomplete 31.76 10.00 98 105687 105933 56080349
Neonatal asphyxia 31.76 10.00 14 105771 281 56186001
Cardio-respiratory arrest 31.65 10.00 195 105590 55126 56131156
Autonomic nervous system imbalance 31.24 10.00 31 105754 2562 56183720
Respiratory arrest 31.10 10.00 127 105658 30498 56155784
Bradypnoea 30.89 10.00 34 105751 3169 56183113
Fracture 30.89 10.00 89 105696 17929 56168353
Miosis 30.77 10.00 49 105736 6543 56179739
Cognitive disorder 30.55 10.00 177 105608 48956 56137326
Ballismus 30.54 10.00 10 105775 84 56186198
Histrionic personality disorder 30.53 10.00 9 105776 51 56186231
Immune reconstitution inflammatory syndrome 30.46 10.00 45 105740 5629 56180653
Osteoarthritis 30.35 10.00 66 105719 80230 56106052
Back pain 30.33 10.00 292 105493 236878 55949404
Self-injurious ideation 30.00 10.00 29 105756 2321 56183961
Psychotic symptom 29.96 10.00 23 105762 1346 56184936
Haematemesis 29.79 10.00 120 105665 28638 56157644
Rhonchi 29.44 10.00 29 105756 2375 56183907
Bradyphrenia 29.26 10.00 48 105737 6572 56179710
Merycism 29.05 10.00 12 105773 204 56186078
Paralysis 29.03 10.00 57 105728 8975 56177307
Chemical burn of oral cavity 28.79 10.00 9 105776 64 56186218
Injection site swelling 28.45 10.00 24 105761 43554 56142728
Sensory loss 28.25 10.00 56 105729 8879 56177403
Affective disorder 28.04 10.00 43 105742 5560 56180722
Phagophobia 27.81 10.00 8 105777 41 56186241
Urinary hesitation 27.59 10.00 26 105759 2016 56184266
Crush syndrome 27.44 10.00 10 105775 119 56186163
Product monitoring error 27.12 10.00 33 105752 3426 56182856
Euphoric mood 26.99 10.00 37 105748 4321 56181961
Osteoporosis 26.86 10.00 35 105750 52017 56134265
Anticholinergic syndrome 26.85 10.00 25 105760 1909 56184373
Language disorder 26.77 10.00 25 105760 1916 56184366
Epilepsy 26.71 10.00 106 105679 25125 56161157
Acute psychosis 26.67 10.00 27 105758 2285 56183997
Mental disorder 26.48 10.00 101 105684 23503 56162779
Herpes zoster 25.79 10.00 66 105719 75823 56110459
Hypotonia 25.79 10.00 53 105732 8624 56177658
Swollen tongue 25.63 10.00 119 105666 30205 56156077
Agranulocytosis 25.46 10.00 97 105688 22562 56163720
Red blood cell sedimentation rate increased 25.38 10.00 19 105766 36604 56149678
Social avoidant behaviour 25.33 10.00 29 105756 2823 56183459
Helplessness 25.30 10.00 12 105773 287 56185995
Foetal exposure during pregnancy 25.19 10.00 128 105657 33695 56152587
Norepinephrine increased 25.11 10.00 8 105777 61 56186221
Tongue movement disturbance 25.07 10.00 12 105773 293 56185989
Newborn persistent pulmonary hypertension 24.99 10.00 11 105774 220 56186062
Visceral congestion 24.81 10.00 12 105773 300 56185982
Antipsychotic drug level decreased 24.74 10.00 12 105773 302 56185980
Agitation neonatal 24.68 10.00 14 105771 489 56185793
Blood bilirubin decreased 24.52 10.00 16 105769 722 56185560
Neonatal hypoxia 24.35 10.00 14 105771 502 56185780
Injection site reaction 24.33 10.00 39 105746 53208 56133074
Emotional disorder 24.32 10.00 64 105721 12231 56174051
Inflammation 24.30 10.00 59 105726 69012 56117270
Thirst 24.30 10.00 60 105725 11030 56175252
Systemic infection 23.72 10.00 30 105755 3239 56183043
Therapy non-responder 23.54 10.00 50 105735 61305 56124977
Sinus tachycardia 23.52 10.00 94 105691 22350 56163932
Neonatal respiratory failure 23.43 10.00 11 105774 257 56186025
Facial nerve disorder 23.40 10.00 14 105771 541 56185741
Sensorimotor disorder 23.37 10.00 13 105772 437 56185845
Hypotension 23.29 10.00 626 105159 249882 55936400
Salivary hypersecretion 23.28 10.00 45 105740 7005 56179277
CYP3A4 polymorphism 23.20 10.00 8 105777 80 56186202
Respiratory disorder neonatal 23.20 10.00 17 105768 927 56185355
Sudden death 23.16 10.00 54 105731 9571 56176711
Incoherent 23.13 10.00 34 105751 4235 56182047
Tachycardia paroxysmal 23.12 10.00 11 105774 265 56186017
Orgasm abnormal 23.11 10.00 8 105777 81 56186201
Substance abuse 23.03 10.00 35 105750 4490 56181792
Fungal infection 23.01 10.00 17 105768 32976 56153306
Tremor neonatal 22.99 10.00 9 105776 132 56186150
Pneumonia aspiration 22.98 10.00 121 105664 32290 56153992
Liver injury 22.79 10.00 27 105758 41821 56144461
Alkalosis hypochloraemic 22.69 10.00 9 105776 137 56186145
Pyelonephritis 22.66 10.00 74 105711 15950 56170332
Postmortem blood drug level increased 22.57 10.00 14 105771 578 56185704
Activation syndrome 22.45 10.00 10 105775 206 56186076
Cerebral ventricle dilatation 22.43 10.00 17 105768 976 56185306
Bursitis 22.28 10.00 12 105773 27570 56158712
Gamma-glutamyltransferase increased 22.16 10.00 116 105669 30889 56155393
Radial nerve palsy 22.12 10.00 13 105772 486 56185796
Joint range of motion decreased 22.06 10.00 10 105775 25355 56160927
Suicidal behaviour 22.05 10.00 25 105760 2408 56183874
Upper respiratory tract infection 21.98 10.00 65 105720 71223 56115059
Bipolar I disorder 21.85 10.00 21 105764 1669 56184613
Abnormal weight gain 21.84 10.00 20 105765 1495 56184787
Apathy 21.80 10.00 47 105738 7907 56178375
Non-cardiogenic pulmonary oedema 21.77 10.00 14 105771 616 56185666
Anaemia macrocytic 21.77 10.00 28 105757 3075 56183207
Hepatocellular injury 21.64 10.00 103 105682 26411 56159871
Sialoadenitis 21.58 10.00 20 105765 1518 56184764
Blood sodium decreased 21.41 10.00 91 105694 22243 56164039
Breast discomfort 20.93 10.00 12 105773 428 56185854
Vagus nerve disorder 20.91 10.00 8 105777 110 56186172
Orthostatic hypotension 20.90 10.00 120 105665 33079 56153203
Cerebellar syndrome 20.82 10.00 29 105756 3438 56182844
Mutism 20.82 10.00 19 105766 1414 56184868
Retinal detachment 20.81 10.00 37 105748 5404 56180878
Reduced facial expression 20.77 10.00 21 105764 1775 56184507
Infantile vomiting 20.71 10.00 8 105777 113 56186169
Giant cell arteritis 20.59 10.00 22 105763 1983 56184299
Dementia 20.57 10.00 75 105710 17083 56169199
Injection site haemorrhage 20.51 10.00 8 105777 22193 56164089
Blood cholesterol increased 20.40 10.00 69 105716 72510 56113772
Natural killer cell count decreased 20.35 10.00 6 105779 34 56186248
Cerebral mass effect 20.27 10.00 15 105770 830 56185452
Blood pressure increased 20.16 10.00 175 105610 145001 56041281
Bradycardia neonatal 20.08 10.00 15 105770 842 56185440
Vertigo 20.04 10.00 173 105612 54399 56131883
Insomnia 20.04 10.00 487 105298 191373 55994909
Thinking abnormal 19.92 10.00 52 105733 9889 56176393
Rhinorrhoea 19.85 10.00 49 105736 56988 56129294
Platelet count decreased 19.74 10.00 118 105667 106265 56080017
Akinesia 19.69 10.00 19 105766 1517 56184765
Neuropathy peripheral 19.69 10.00 113 105672 102780 56083502
Labelled drug-drug interaction medication error 19.64 10.00 57 105728 11529 56174753
Thymus disorder 19.48 10.00 10 105775 285 56185997
Cataract 19.47 10.00 42 105743 51205 56135077
Purple glove syndrome 19.42 10.00 9 105776 204 56186078
Hyperthermia 19.41 10.00 46 105739 8239 56178043
Stoma site discharge 19.23 10.00 18 105767 1384 56184898
Tinnitus 19.18 10.00 109 105676 29933 56156349
Mental impairment 19.12 10.00 60 105725 12662 56173620
Vitamin B12 decreased 18.88 10.00 26 105759 3049 56183233
Skin exfoliation 18.85 10.00 25 105760 36875 56149407
Status epilepticus 18.84 10.00 67 105718 15074 56171208
COVID-19 18.70 10.00 75 105710 74983 56111299
Bulimia nervosa 18.67 10.00 11 105774 413 56185869
Tachyphrenia 18.60 10.00 17 105768 1267 56185015
Freezing phenomenon 18.60 10.00 16 105769 1101 56185181
Drop attacks 18.59 10.00 13 105772 658 56185624
Hypotonia neonatal 18.51 10.00 16 105769 1108 56185174
Neglect of personal appearance 18.44 10.00 7 105778 94 56186188
Acute abdomen 18.44 10.00 18 105767 1458 56184824
Musculoskeletal stiffness 18.30 10.00 196 105589 155811 56030471
False positive investigation result 18.22 10.00 12 105773 550 56185732
Suspected suicide 18.18 10.00 35 105750 5431 56180851
Illusion 18.12 10.00 15 105770 979 56185303
Drug reaction with eosinophilia and systemic symptoms 18.08 10.00 108 105677 30196 56156086
Anaphylactic reaction 18.04 10.00 54 105731 58941 56127341
Serum serotonin increased 17.99 10.00 8 105777 164 56186118
Skin ulcer 17.90 10.00 28 105757 38580 56147702
Bundle branch block right 17.80 10.00 32 105753 4715 56181567
Hallucination, synaesthetic 17.77 10.00 6 105779 56 56186226
Cytomegalovirus infection 17.75 10.00 7 105778 19289 56166993
Bipolar disorder 17.66 10.00 42 105743 7538 56178744
Compulsive shopping 17.66 10.00 13 105772 714 56185568
Agonal rhythm 17.65 10.00 5 105780 24 56186258
Tearfulness 17.58 10.00 28 105757 3740 56182542
Febrile neutropenia 17.57 10.00 121 105664 105424 56080858
Upper gastrointestinal haemorrhage 17.53 10.00 71 105714 16983 56169299
Pyroglutamic acidosis 17.50 10.00 11 105774 465 56185817
Brief psychotic disorder with marked stressors 17.49 10.00 6 105779 59 56186223
Negative thoughts 17.48 10.00 14 105771 872 56185410
Adverse event 17.43 10.00 50 105735 55326 56130956
Nephrolithiasis 17.39 10.00 27 105758 37308 56148974
Cellulitis orbital 17.35 10.00 11 105774 472 56185810
Snoring 17.24 10.00 27 105758 3554 56182728
Macular degeneration 17.16 10.00 7 105778 18901 56167381
Therapeutic response decreased 17.08 10.00 47 105738 52711 56133571
Medication error 17.03 10.00 137 105648 42198 56144084
Drug dose titration not performed 16.96 10.00 11 105774 491 56185791
Balance disorder 16.95 10.00 219 105566 76301 56109981
Lower limb fracture 16.92 10.00 6 105779 17649 56168633
Premature labour 16.91 10.00 55 105730 11827 56174455
Hyperreflexia 16.71 10.00 33 105752 5217 56181065
Pulmonary renal syndrome 16.47 10.00 10 105775 397 56185885
Spina bifida 16.43 10.00 13 105772 795 56185487
Premature delivery 16.36 10.00 16 105769 27044 56159238
Respiratory depression 16.32 10.00 56 105729 12379 56173903
Aptyalism 16.31 10.00 11 105774 525 56185757
Post-traumatic stress disorder 16.27 10.00 30 105755 4508 56181774
Wheezing 16.25 10.00 79 105706 74947 56111335
Homicidal ideation 16.25 10.00 18 105767 1690 56184592
Hypothermia 16.22 10.00 56 105729 12414 56173868
Blood pressure diastolic decreased 16.21 10.00 8 105777 19315 56166967
Stoma site inflammation 16.20 10.00 10 105775 409 56185873
Binge eating 16.16 10.00 10 105775 411 56185871
Hyperacusis 16.11 10.00 19 105766 1909 56184373
Faecaloma 16.03 10.00 40 105745 7401 56178881
Empty sella syndrome 15.94 10.00 5 105780 36 56186246
Cardiac hypertrophy 15.86 10.00 14 105771 997 56185285
Injection site rash 15.85 10.00 6 105779 16952 56169330
Fibromyalgia 15.85 10.00 58 105727 59545 56126737
Essential tremor 15.72 10.00 14 105771 1009 56185273
Medulloblastoma 15.71 10.00 5 105780 38 56186244
Gastrooesophageal reflux disease 15.63 10.00 92 105693 83165 56103117
Alcoholism 15.60 10.00 20 105765 2189 56184093
Aspartate aminotransferase decreased 15.56 10.00 12 105773 707 56185575
Pulse absent 15.55 10.00 31 105754 4936 56181346
Decubitus ulcer 15.53 10.00 47 105738 9728 56176554
Parkinsonian gait 15.49 10.00 10 105775 443 56185839
Torsade de pointes 15.44 10.00 55 105730 12385 56173897
Drowning 15.43 10.00 10 105775 446 56185836
Loss of libido 15.30 10.00 15 105770 1221 56185061
Aspergillus test positive 15.30 10.00 9 105776 337 56185945
Catatonia 15.22 10.00 27 105758 3937 56182345
Death 15.04 10.00 785 105000 340641 55845641
Vasodilatation 14.82 10.00 20 105765 2301 56183981
Refusal of treatment by patient 14.82 10.00 31 105754 5107 56181175
Resuscitation 14.82 10.00 14 105771 1089 56185193
Enterococcus test positive 14.78 10.00 14 105771 1092 56185190
Skull fracture 14.76 10.00 13 105772 923 56185359
Granulocytopenia neonatal 14.71 10.00 4 105781 16 56186266
Dyspraxia 14.68 10.00 8 105777 258 56186024
Transferrin saturation decreased 14.63 10.00 11 105774 624 56185658
Logorrhoea 14.61 10.00 20 105765 2332 56183950
Developmental hip dysplasia 14.56 10.00 15 105770 1296 56184986
Eyelid myoclonus 14.52 10.00 6 105779 102 56186180
Palmar-plantar erythrodysaesthesia syndrome 14.50 10.00 11 105774 21054 56165228
Antidepressant drug level increased 14.49 10.00 8 105777 265 56186017
Exostosis 14.46 10.00 5 105780 14938 56171344
Neck pain 14.41 10.00 63 105722 61492 56124790
Pneumonia 14.39 10.00 622 105163 406476 55779806
Pulmonary vein occlusion 14.36 10.00 6 105779 105 56186177
Thyroxine free decreased 14.34 10.00 11 105774 643 56185639
Basophil count decreased 14.31 10.00 6 105779 106 56186176
Psychiatric decompensation 14.31 10.00 15 105770 1323 56184959
Gait disturbance 14.27 10.00 405 105380 162916 56023366
Tenosynovitis 14.25 10.00 3 105782 12458 56173824
Parkinson's disease 14.25 10.00 15 105770 1329 56184953
Myocardial infarction 14.24 10.00 109 105676 92761 56093521
Interstitial lung disease 14.22 10.00 57 105728 57006 56129276
Ear infection 14.22 10.00 23 105762 31272 56155010
Intrusive thoughts 14.22 10.00 7 105778 182 56186100
Skin necrosis 14.09 10.00 3 105782 12358 56173924
Extensor plantar response 14.02 10.00 14 105771 1166 56185116
Liver disorder 14.01 10.00 40 105745 44330 56141952
Sinus congestion 13.99 10.00 6 105779 15718 56170564
Therapeutic drug monitoring analysis not performed 13.97 10.00 13 105772 992 56185290
Indifference 13.96 10.00 6 105779 113 56186169
B-lymphocyte count increased 13.96 10.00 6 105779 113 56186169
Dystrophic calcification 13.91 10.00 6 105779 114 56186168
Creatinine renal clearance decreased 13.86 10.00 5 105780 14554 56171728
Maternal drugs affecting foetus 13.85 10.00 30 105755 5063 56181219
Shared psychotic disorder 13.82 10.00 4 105781 21 56186261
Congenital hand malformation 13.81 10.00 8 105777 291 56185991
Product quality issue 13.80 10.00 24 105761 31712 56154570
Stoma site hypergranulation 13.79 10.00 8 105777 292 56185990
Dysdiadochokinesis 13.77 10.00 6 105779 117 56186165
Intestinal mucosal atrophy 13.76 10.00 3 105782 3 56186279
Spontaneous haemorrhage 13.76 10.00 8 105777 293 56185989
Compulsive sexual behaviour 13.76 10.00 5 105780 59 56186223
Respiratory distress 13.72 10.00 24 105761 31643 56154639
Migraine 13.72 10.00 101 105684 86696 56099586
Stupor 13.70 10.00 26 105759 3992 56182290
Optic nerve disorder 13.65 10.00 11 105774 691 56185591
Anal infection 13.61 10.00 5 105780 61 56186221
Polydipsia psychogenic 13.61 10.00 5 105780 61 56186221
Personality disorder 13.53 10.00 30 105755 5143 56181139
Fluid retention 13.49 10.00 54 105731 54024 56132258
Mobility decreased 13.44 10.00 120 105665 98871 56087411
Dyspnoea at rest 13.41 10.00 25 105760 3788 56182494
Somatic delusion 13.38 10.00 10 105775 562 56185720
Chest pain 13.28 10.00 264 105521 189533 55996749
Bradycardia 13.23 10.00 189 105596 67315 56118967
Rabbit syndrome 13.21 10.00 8 105777 316 56185966
C-reactive protein increased 13.20 10.00 90 105695 78594 56107688
Long QT syndrome 13.19 10.00 22 105763 3054 56183228
Viral infection 13.14 10.00 25 105760 31921 56154361
Retrograde amnesia 13.11 10.00 9 105776 442 56185840
Abdominal pain upper 13.10 10.00 246 105539 178067 56008215
Orthostatic intolerance 13.08 10.00 13 105772 1076 56185206
Selective eating disorder 13.07 10.00 17 105768 1887 56184395
Tendonitis 13.05 10.00 9 105776 18088 56168194
Increased appetite 12.95 10.00 41 105744 8694 56177588
Blood pressure diastolic abnormal 12.85 10.00 3 105782 11595 56174687
Kussmaul respiration 12.81 10.00 7 105778 227 56186055
Generalised anxiety disorder 12.79 10.00 17 105768 1927 56184355
Paranasal sinus inflammation 12.78 10.00 9 105776 461 56185821
Pyrexia 12.77 10.00 650 105135 418123 55768159
Arrhythmia 12.77 10.00 111 105674 34972 56151310
Glassy eyes 12.73 10.00 5 105780 74 56186208
Dreamy state 12.73 10.00 4 105781 29 56186253
Somnambulism 12.73 10.00 29 105756 5063 56181219
Influenza 12.70 10.00 116 105669 95145 56091137
Mixed anxiety and depressive disorder 12.70 10.00 7 105778 231 56186051
Clonus 12.68 10.00 26 105759 4223 56182059
Breast cancer 12.67 10.00 48 105737 48785 56137497
Obsessive-compulsive disorder 12.66 10.00 24 105761 3682 56182600
Nail avulsion 12.63 10.00 6 105779 144 56186138
Lipohypertrophy 12.61 10.00 10 105775 614 56185668
Visual acuity reduced transiently 12.59 10.00 6 105779 145 56186137
Gambling 12.57 10.00 7 105778 236 56186046
Fibula agenesis 12.55 10.00 3 105782 6 56186276
Agoraphobia 12.48 10.00 8 105777 350 56185932
Bronchitis 12.41 10.00 143 105642 112168 56074114
Acute kidney injury 12.36 10.00 562 105223 240201 55946081
Heart rate decreased 12.36 10.00 37 105748 40390 56145892
Abdominal rigidity 12.35 10.00 16 105769 1769 56184513
Paraesthesia 12.35 10.00 327 105458 130187 56056095
Regressive behaviour 12.33 10.00 6 105779 152 56186130
Phaeochromocytoma 12.29 10.00 9 105776 490 56185792
Transfusion 12.28 10.00 5 105780 13515 56172767
Dry mouth 12.28 10.00 179 105606 64026 56122256
Poor feeding infant 12.23 10.00 7 105778 249 56186033
Hyperphagia 12.15 10.00 15 105770 1581 56184701
Cerebellar haematoma 12.14 10.00 8 105777 367 56185915
Product complaint 12.12 10.00 49 105736 11711 56174571
Chemical burns of eye 12.10 10.00 5 105780 85 56186197
No adverse event 12.07 10.00 32 105753 36342 56149940
Cardiac failure congestive 12.06 10.00 106 105679 87614 56098668
Antiphospholipid antibodies 12.05 10.00 6 105779 160 56186122
Obsessive-compulsive symptom 12.05 10.00 5 105780 86 56186196
Ear pain 11.99 10.00 25 105760 30865 56155417
Basal cell carcinoma 11.97 10.00 18 105767 25203 56161079
Snake bite 11.95 10.00 3 105782 8 56186274
Communication disorder 11.93 10.00 18 105767 2295 56183987
Flushing 11.85 10.00 80 105705 70020 56116262
Inappropriate affect 11.83 10.00 11 105774 838 56185444
Mucosal inflammation 11.82 10.00 41 105744 42769 56143513
Somatic symptom disorder 11.81 10.00 17 105768 2078 56184204
Injection site warmth 11.80 10.00 6 105779 14237 56172045
Failure to thrive 11.79 10.00 33 105752 6537 56179745
Ataxia 11.79 10.00 56 105729 14347 56171935
Cerebral atrophy 11.77 10.00 27 105758 4733 56181549
Productive cough 11.72 10.00 60 105725 56172 56130110
Sinus disorder 11.70 10.00 13 105772 20721 56165561
Product confusion 11.69 10.00 3 105782 9 56186273
Peripheral paralysis 11.69 10.00 5 105780 93 56186189
Haemoptysis 11.63 10.00 20 105765 26540 56159742
Polyneuropathy 11.61 10.00 52 105733 12998 56173284
Joint injury 11.52 10.00 19 105766 25635 56160647
Formication 11.50 10.00 24 105761 3946 56182336
Tic 11.42 10.00 13 105772 1258 56185024
Dizziness 11.39 10.00 837 104948 375303 55810979
Infantile apnoea 11.38 10.00 11 105774 880 56185402
Antipsychotic drug level below therapeutic 11.35 10.00 7 105778 286 56185996
Blood pressure systolic increased 11.35 10.00 39 105746 40797 56145485
Labelled drug-disease interaction issue 11.26 10.00 4 105781 44 56186238
Oedema 11.25 10.00 99 105686 81821 56104461
Injection site urticaria 11.18 10.00 5 105780 12778 56173504
Secretion discharge 11.16 10.00 3 105782 10543 56175739
Food craving 11.12 10.00 14 105771 1505 56184777
Ocular hyperaemia 11.11 10.00 15 105770 21964 56164318
Central nervous system inflammation 11.11 10.00 6 105779 190 56186092
Potentiating drug interaction 11.11 10.00 24 105761 4042 56182240
Contusion 11.11 10.00 172 105613 128258 56058024
Staphylococcal infection 11.09 10.00 35 105750 37583 56148699
Electrocardiogram abnormal 10.97 10.00 37 105748 8107 56178175
Post viral fatigue syndrome 10.97 10.00 7 105778 304 56185978
Sleep terror 10.94 10.00 10 105775 746 56185536
Adrenal cyst 10.92 10.00 5 105780 110 56186172
Arachnoid cyst 10.91 10.00 6 105779 197 56186085
Anaphylactic shock 10.83 10.00 15 105770 21725 56164557
Pulmonary haematoma 10.80 10.00 4 105781 50 56186232
Decreased interest 10.75 10.00 20 105765 3026 56183256
Skin lesion 10.73 10.00 23 105762 28112 56158170
Crying 10.68 10.00 73 105712 21367 56164915
Hypernatraemia 10.68 10.00 32 105753 6588 56179694
Eye irritation 10.66 10.00 12 105773 19016 56167266
Hemianopia homonymous 10.63 10.00 9 105776 606 56185676
Electrocardiogram T wave inversion 10.63 10.00 21 105764 3322 56182960
Blood alkaline phosphatase increased 10.62 10.00 116 105669 38829 56147453
Compulsions 10.62 10.00 6 105779 208 56186074
Therapy interrupted 10.59 10.00 20 105765 25605 56160677
Grip strength decreased 10.55 10.00 9 105776 16247 56170035
Poverty of thought content 10.49 10.00 3 105782 15 56186267
Rash pruritic 10.47 10.00 57 105728 52537 56133745
Pharyngeal erythema 10.44 10.00 14 105771 1601 56184681
Immunodeficiency 10.42 10.00 9 105776 16148 56170134
Acquired epidermolysis bullosa 10.39 10.00 4 105781 56 56186226
Large for dates baby 10.38 10.00 8 105777 471 56185811
Foot deformity 10.37 10.00 18 105767 23807 56162475
Bifascicular block 10.34 10.00 5 105780 125 56186157
Hyporesponsive to stimuli 10.34 10.00 11 105774 987 56185295
Disseminated intravascular coagulation 10.33 10.00 11 105774 17874 56168408
Acute myeloid leukaemia 10.30 10.00 10 105775 16962 56169320
Granulocyte percentage 10.26 10.00 4 105781 58 56186224
Drug withdrawal headache 10.26 10.00 4 105781 58 56186224
Personality change 10.23 10.00 29 105756 5788 56180494
Neuropsychiatric symptoms 10.18 10.00 9 105776 642 56185640
Postural tremor 10.14 10.00 6 105779 227 56186055
Glomerular filtration rate decreased 10.14 10.00 48 105737 12281 56174001
Gamma-glutamyltransferase abnormal 10.12 10.00 6 105779 228 56186054
Metamyelocyte count increased 10.12 10.00 6 105779 228 56186054
Acne 10.12 10.00 15 105770 21121 56165161
Ocular discomfort 10.07 10.00 22 105763 3733 56182549
Osteomyelitis 10.06 10.00 19 105766 24327 56161955
Rash erythematous 10.04 10.00 36 105749 37185 56149097
HIV-associated neurocognitive disorder 10.02 10.00 5 105780 134 56186148
Pulmonary fibrosis 10.01 10.00 26 105759 29732 56156550

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 496.56 10.50 1208 71773 180279 31444084
Intentional overdose 440.28 10.50 509 72472 40880 31583483
Intentional self-injury 377.09 10.50 283 72698 13032 31611331
Suicide attempt 354.69 10.50 433 72548 36815 31587548
Completed suicide 347.97 10.50 696 72285 90818 31533545
Serotonin syndrome 283.03 10.50 278 72703 18495 31605868
Suicidal ideation 278.78 10.50 380 72601 36026 31588337
Agitation 272.44 10.50 465 72516 53704 31570659
Confusional state 217.59 10.50 738 72243 132596 31491767
Somnolence 216.71 10.50 609 72372 98836 31525527
Drug abuse 211.75 10.50 558 72423 87200 31537163
Overdose 205.97 10.50 540 72441 84124 31540239
Sopor 170.23 10.50 169 72812 11383 31612980
Anxiety 162.75 10.50 520 72461 90513 31533850
Coma 153.72 10.50 311 72670 40839 31583524
Depression 153.55 10.50 509 72472 90306 31534057
Restlessness 142.46 10.50 219 72762 23142 31601221
Extrapyramidal disorder 142.43 10.50 155 72826 11623 31612740
Sedation 125.91 10.50 185 72796 18780 31605583
Aggression 120.87 10.50 266 72715 37025 31587338
Drug interaction 106.93 10.50 833 72148 207710 31416653
Hallucination, visual 103.30 10.50 153 72828 15641 31608722
Fall 103.07 10.50 757 72224 185332 31439031
Intrusive thoughts 100.19 10.50 34 72947 257 31624106
Delirium 99.35 10.50 263 72718 41158 31583205
Restless legs syndrome 98.92 10.50 105 72876 7651 31616712
Drug withdrawal syndrome 98.16 10.50 164 72817 18586 31605777
Neuroleptic malignant syndrome 95.69 10.50 153 72828 16716 31607647
Withdrawal syndrome 92.18 10.50 124 72857 11593 31612770
Depressed mood 91.04 10.50 153 72828 17422 31606941
Nightmare 90.27 10.50 125 72856 12012 31612351
Febrile neutropenia 89.62 10.50 89 72892 121760 31502603
Accidental overdose 88.81 10.50 155 72826 18195 31606168
Insomnia 85.58 10.50 438 72543 94398 31529965
Tremor 84.23 10.50 374 72607 76046 31548317
Electrocardiogram QT prolonged 83.89 10.50 234 72747 37753 31586610
Hallucination, auditory 83.58 10.50 111 72870 10249 31614114
Psychotic disorder 81.44 10.50 167 72814 22126 31602237
Mania 79.75 10.50 102 72879 9075 31615288
Akathisia 76.66 10.50 89 72892 7164 31617199
Parkinsonism 74.59 10.50 90 72891 7546 31616817
Bradyphrenia 73.48 10.50 69 72912 4335 31620028
Depressed level of consciousness 72.07 10.50 224 72757 38377 31585986
Disorientation 70.47 10.50 192 72789 30552 31593811
Dyskinesia 67.55 10.50 149 72832 20761 31603602
Logorrhoea 67.20 10.50 50 72931 2269 31622094
Wrong patient received product 67.15 10.50 52 72929 2507 31621856
Pneumonia aspiration 64.39 10.50 216 72765 38510 31585853
Progressive multifocal leukoencephalopathy 64.23 10.50 92 72889 9121 31615242
Abnormal behaviour 64.06 10.50 158 72823 23670 31600693
Paranoia 62.99 10.50 98 72883 10457 31613906
Tachyphrenia 61.29 10.50 37 72944 1180 31623183
Antidepressant drug level above therapeutic 60.80 10.50 22 72959 205 31624158
Homicidal ideation 60.16 10.50 49 72932 2542 31621821
Myoclonus 59.83 10.50 112 72869 13878 31610485
Muscle twitching 58.58 10.50 83 72898 8147 31616216
Interstitial lung disease 57.59 10.50 35 72946 61368 31562995
Hallucination 57.17 10.50 235 72746 46175 31578188
Disturbance in attention 56.31 10.50 145 72836 22305 31602058
Rheumatoid arthritis 56.02 10.50 20 72961 47789 31576574
Psychomotor hyperactivity 53.02 10.50 82 72899 8705 31615658
Inappropriate antidiuretic hormone secretion 52.27 10.50 94 72887 11293 31613070
Panic attack 52.21 10.50 81 72900 8622 31615741
Poisoning 51.88 10.50 89 72892 10302 31614061
Pruritus 51.74 10.50 134 72847 125033 31499330
Apathy 51.59 10.50 69 72912 6413 31617950
Sleep disorder 51.13 10.50 155 72826 26193 31598170
Delusion 50.00 10.50 95 72886 11902 31612461
Muscle rigidity 48.40 10.50 84 72897 9813 31614550
Tachycardia 47.89 10.50 320 72661 75887 31548476
Poisoning deliberate 47.80 10.50 71 72910 7273 31617090
Hypomania 47.18 10.50 40 72941 2195 31622168
On and off phenomenon 47.10 10.50 39 72942 2071 31622292
Bradykinesia 46.46 10.50 49 72932 3543 31620820
Loss of consciousness 46.34 10.50 321 72660 77034 31547329
Mood swings 45.80 10.50 70 72911 7354 31617009
Analgesic drug level above therapeutic 44.79 10.50 19 72962 279 31624084
Systemic infection 44.52 10.50 47 72934 3402 31620961
Nasopharyngitis 43.31 10.50 49 72932 63196 31561167
Illusion 43.18 10.50 25 72956 737 31623626
Off label use 43.09 10.50 553 72428 346721 31277642
Priapism 42.76 10.50 53 72928 4567 31619796
Myocardial infarction 42.76 10.50 127 72854 113327 31511036
Anger 42.45 10.50 85 72896 11068 31613295
Pulmonary congestion 40.22 10.50 91 72890 12892 31611471
Cough 40.02 10.50 167 72814 134647 31489716
Platelet count decreased 39.92 10.50 126 72855 110309 31514054
Major depression 39.70 10.50 49 72932 4204 31620159
Illness anxiety disorder 39.66 10.50 15 72966 160 31624203
Altered state of consciousness 39.13 10.50 122 72859 20929 31603434
Pyrexia 39.10 10.50 480 72501 303360 31321003
Atrial fibrillation 38.93 10.50 133 72848 113650 31510713
Miosis 38.39 10.50 70 72911 8500 31615863
Antipsychotic drug level above therapeutic 37.78 10.50 27 72954 1150 31623213
Asthma 37.62 10.50 26 72955 42585 31581778
Pneumonia 37.60 10.50 545 72436 334767 31289596
Loss of libido 37.06 10.50 36 72945 2359 31622004
Dystonia 36.63 10.50 76 72905 10149 31614214
Infusion related reaction 36.57 10.50 34 72947 48021 31576342
Vestibular disorder 35.50 10.50 25 72956 1040 31623323
Rash 35.10 10.50 296 72685 201190 31423173
Arthralgia 34.92 10.50 205 72776 151219 31473144
General physical health deterioration 34.88 10.50 407 72574 113028 31511335
Product prescribing error 34.82 10.50 112 72869 19530 31604833
Renal failure 34.63 10.50 156 72825 123174 31501189
Hyponatraemic coma 34.05 10.50 9 72972 24 31624339
Irritability 33.98 10.50 123 72858 22766 31601597
Hyponatraemia 33.98 10.50 288 72693 73511 31550852
Drug hypersensitivity 33.74 10.50 73 72908 72526 31551837
Tardive dyskinesia 33.71 10.50 52 72929 5507 31618856
Cardiac failure congestive 33.54 10.50 84 72897 79303 31545060
Disease progression 33.54 10.50 102 72879 90362 31534001
Mental disorder 33.30 10.50 88 72893 13746 31610617
Pleurothotonus 32.84 10.50 24 72957 1059 31623304
Respiratory depression 32.62 10.50 90 72891 14420 31609943
Drug ineffective 32.15 10.50 681 72300 394892 31229471
Accidental death 31.85 10.50 32 72949 2185 31622178
Aptyalism 31.82 10.50 15 72966 286 31624077
Respiratory arrest 31.57 10.50 132 72849 26125 31598238
Substance abuse 31.47 10.50 58 72923 7100 31617263
Rhabdomyolysis 31.34 10.50 252 72729 63329 31561034
Urinary retention 31.23 10.50 157 72824 33568 31590795
Blood creatine phosphokinase increased 31.18 10.50 184 72797 41790 31582573
Decreased gait velocity 30.92 10.50 12 72969 138 31624225
Injection site pain 30.75 10.50 21 72960 34613 31589750
Pleural effusion 30.33 10.50 81 72900 74839 31549524
Persecutory delusion 30.27 10.50 32 72949 2320 31622043
Drug dependence 29.93 10.50 117 72864 22462 31601901
Urogenital haemorrhage 29.90 10.50 18 72963 571 31623792
Feelings of worthlessness 29.83 10.50 14 72967 264 31624099
Neuropathy peripheral 29.71 10.50 83 72898 75566 31548797
Cytomegalovirus infection 29.52 10.50 10 72971 24697 31599666
Nasal discomfort 29.35 10.50 26 72955 1514 31622849
Prostate cancer 29.32 10.50 26 72955 37575 31586788
Catatonia 29.14 10.50 45 72936 4769 31619594
Electrocardiogram abnormal 29.10 10.50 60 72921 7976 31616387
Thrombocytopenia 28.94 10.50 201 72780 142546 31481817
Herpes zoster 28.94 10.50 19 72962 31974 31592389
Dysarthria 28.91 10.50 148 72833 31869 31592494
Selective eating disorder 28.79 10.50 27 72954 1693 31622670
Stomatitis 28.73 10.50 29 72952 39409 31584954
Sudden cardiac death 27.89 10.50 37 72944 3412 31620951
Platypnoea 27.81 10.50 8 72973 32 31624331
Sepsis 27.43 10.50 221 72760 151708 31472655
Alcohol use 27.20 10.50 35 72946 3132 31621231
Asphyxia 27.07 10.50 48 72933 5703 31618660
Cardiac failure 27.05 10.50 104 72877 85849 31538514
Sarcopenia 25.90 10.50 14 72967 360 31624003
Macrophages increased 25.78 10.50 11 72970 164 31624199
Patient elopement 25.63 10.50 7 72974 22 31624341
Pressure of speech 25.52 10.50 15 72966 455 31623908
Erythema 25.49 10.50 97 72884 80308 31544055
Hyperhidrosis 25.43 10.50 252 72729 67141 31557222
Hallucinations, mixed 25.37 10.50 30 72951 2462 31621901
Feeling jittery 25.28 10.50 37 72944 3740 31620623
Arthritis 25.13 10.50 16 72965 27369 31596994
Prescription drug used without a prescription 25.03 10.50 23 72958 1405 31622958
Oesophageal obstruction 25.03 10.50 15 72966 472 31623891
Urticaria 24.96 10.50 60 72921 57457 31566906
Depersonalisation/derealisation disorder 24.92 10.50 16 72965 570 31623793
Hyperreflexia 24.40 10.50 32 72949 2917 31621446
Benign gastrointestinal neoplasm 24.33 10.50 10 72971 135 31624228
Mood altered 24.20 10.50 57 72924 8289 31616074
Wrong product administered 24.07 10.50 42 72939 4926 31619437
Myelosuppression 24.05 10.50 3 72978 14917 31609446
Diarrhoea 24.04 10.50 623 72358 351786 31272577
Congenital cerebrovascular anomaly 23.89 10.50 6 72975 12 31624351
Postictal state 23.73 10.50 17 72964 727 31623636
Dysphoria 23.53 10.50 27 72954 2145 31622218
Product monitoring error 23.14 10.50 33 72948 3257 31621106
Septic shock 22.83 10.50 77 72904 66081 31558282
Bipolar disorder 22.81 10.50 35 72946 3689 31620674
Urinary hesitation 22.77 10.50 28 72953 2393 31621970
Seizure 22.73 10.50 339 72642 99429 31524934
Depressive symptom 22.44 10.50 26 72955 2088 31622275
Dementia with Lewy bodies 22.42 10.50 16 72965 680 31623683
COVID-19 22.38 10.50 59 72922 54762 31569601
Joint swelling 22.20 10.50 57 72924 53374 31570989
IVth nerve disorder 22.18 10.50 6 72975 18 31624345
JC virus infection 21.96 10.50 25 72956 1969 31622394
Thinking abnormal 21.84 10.50 43 72938 5530 31618833
Intentional product use issue 21.79 10.50 51 72930 49296 31575067
Suspected suicide 21.59 10.50 36 72945 4071 31620292
Cold sweat 21.58 10.50 58 72923 9151 31615212
Sinusitis 21.44 10.50 32 72949 36664 31587699
Acute kidney injury 21.09 10.50 487 72494 279227 31345136
Myelodysplastic syndrome 20.98 10.50 9 72972 19242 31605121
Cogwheel rigidity 20.98 10.50 20 72961 1280 31623083
Psoriasis 20.86 10.50 48 72933 46671 31577692
Activation syndrome 20.69 10.50 8 72973 91 31624272
Nervousness 20.66 10.50 67 72914 11733 31612630
Dry skin 20.62 10.50 17 72964 25464 31598899
Inappropriate schedule of product administration 20.52 10.50 55 72926 50768 31573595
Circulatory collapse 20.50 10.50 95 72886 19649 31604714
Slow speech 20.50 10.50 18 72963 1036 31623327
Antipsychotic drug level increased 20.48 10.50 32 72949 3426 31620937
Homicide 20.33 10.50 17 72964 915 31623448
Postoperative respiratory failure 20.31 10.50 8 72973 96 31624267
Congenital hyperinsulinaemic hypoglycaemia 20.30 10.50 4 72977 0 31624363
Dysgraphia 20.13 10.50 25 72956 2158 31622205
Upper respiratory tract infection 19.91 10.50 23 72958 29399 31594964
Hypertonia 19.82 10.50 34 72947 3934 31620429
Acute myocardial infarction 19.77 10.50 56 72925 50767 31573596
Perforated ulcer 19.71 10.50 9 72972 159 31624204
Parkinsonian gait 19.67 10.50 13 72968 487 31623876
Tubulointerstitial nephritis 19.61 10.50 9 72972 18487 31605876
Peripheral swelling 19.54 10.50 85 72896 67780 31556583
Alcoholism 19.50 10.50 31 72950 3368 31620995
Feeling guilty 19.44 10.50 11 72970 310 31624053
Mental impairment 19.36 10.50 57 72924 9475 31614888
White blood cell count decreased 19.24 10.50 120 72861 87278 31537085
Malignant neoplasm progression 19.24 10.50 105 72876 78893 31545470
Helplessness 19.09 10.50 7 72974 68 31624295
Acute psychosis 19.06 10.50 22 72959 1759 31622604
Verbal abuse 19.02 10.50 9 72972 173 31624190
Tumour lysis syndrome 18.78 10.50 6 72975 15379 31608984
Intentional device misuse 18.75 10.50 9 72972 179 31624184
Hanging 18.71 10.50 8 72973 120 31624243
Bezoar 18.65 10.50 16 72965 892 31623471
Neutropenia 18.65 10.50 220 72761 140144 31484219
Respiratory disorder neonatal 18.64 10.50 20 72961 1475 31622888
Haemoglobin decreased 18.49 10.50 168 72813 112507 31511856
Hyperkinesia 18.47 10.50 21 72960 1652 31622711
Hypersomnia 18.45 10.50 62 72919 11057 31613306
Acute myeloid leukaemia 18.41 10.50 10 72971 18662 31605701
Multiple organ dysfunction syndrome 18.10 10.50 88 72893 68115 31556248
Obsessive-compulsive disorder 18.04 10.50 37 72944 4900 31619463
Back pain 18.01 10.50 163 72818 109250 31515113
Arachnoid cyst 17.92 10.50 9 72972 198 31624165
Tracheal pain 17.84 10.50 6 72975 44 31624319
Nephrolithiasis 17.83 10.50 22 72959 27317 31597046
Derealisation 17.82 10.50 13 72968 572 31623791
Hypervigilance 17.80 10.50 8 72973 136 31624227
Eosinophilic myocarditis 17.79 10.50 12 72969 465 31623898
Product prescribing issue 17.61 10.50 20 72961 1571 31622792
Delusion of grandeur 17.58 10.50 14 72967 703 31623660
Drug withdrawal syndrome neonatal 17.55 10.50 30 72951 3462 31620901
Fear of weight gain 17.54 10.50 4 72977 4 31624359
Gout 17.54 10.50 10 72971 18164 31606199
Hangover 17.53 10.50 16 72965 969 31623394
Ejaculation disorder 17.46 10.50 16 72965 974 31623389
Epilepsy 17.44 10.50 95 72886 20946 31603417
Implant site extravasation 17.41 10.50 11 72970 381 31623982
Blood creatinine increased 17.27 10.50 127 72854 88951 31535412
Stoma site infection 17.23 10.50 14 72967 724 31623639
Arthropathy 17.16 10.50 18 72963 24033 31600330
Dementia 17.15 10.50 65 72916 12295 31612068
Temperature regulation disorder 17.11 10.50 13 72968 609 31623754
Osteonecrosis of jaw 17.04 10.50 9 72972 17062 31607301
Electrocardiogram QRS complex prolonged 17.02 10.50 33 72948 4196 31620167
Incoherent 16.94 10.50 33 72948 4211 31620152
Intentional product misuse 16.87 10.50 147 72834 37804 31586559
Amnestic disorder 16.81 10.50 9 72972 227 31624136
Alcohol interaction 16.78 10.50 26 72955 2763 31621600
Ejaculation failure 16.69 10.50 14 72967 757 31623606
Mastication disorder 16.64 10.50 17 72964 1184 31623179
Loose associations 16.57 10.50 6 72975 56 31624307
Eosinophilic pleural effusion 16.53 10.50 9 72972 235 31624128
Ataxia 16.51 10.50 66 72915 12797 31611566
Sexual dysfunction 16.49 10.50 40 72941 5928 31618435
Respiratory tract infection 16.47 10.50 10 72971 17551 31606812
Posture abnormal 16.47 10.50 22 72959 2042 31622321
Oesophageal haemorrhage 16.38 10.50 17 72964 1206 31623157
Urine sodium decreased 16.23 10.50 8 72973 169 31624194
Metabolic syndrome 16.21 10.50 19 72962 1544 31622819
Hyperbilirubinaemia 16.18 10.50 8 72973 15742 31608621
Plasma cell myeloma 16.15 10.50 71 72910 56460 31567903
Ascites 16.09 10.50 45 72936 40968 31583395
Speech disorder 16.02 10.50 103 72878 24098 31600265
Gait disturbance 15.99 10.50 259 72722 77236 31547127
Psychomotor skills impaired 15.89 10.50 27 72954 3100 31621263
Rapid eye movements sleep abnormal 15.89 10.50 8 72973 177 31624186
Bladder cancer 15.87 10.50 7 72974 14718 31609645
Abdominal discomfort 15.83 10.50 63 72918 51504 31572859
Amnesia 15.73 10.50 100 72881 23302 31601061
Abnormal weight gain 15.72 10.50 15 72966 961 31623402
Tricuspid valve sclerosis 15.72 10.50 5 72976 30 31624333
Palmar-plantar erythrodysaesthesia syndrome 15.70 10.50 8 72973 15475 31608888
Mucosal inflammation 15.67 10.50 35 72946 34392 31589971
JC virus CSF test positive 15.63 10.50 7 72974 118 31624245
Sinus bradycardia 15.50 10.50 62 72919 12025 31612338
Infant irritability 15.45 10.50 5 72976 32 31624331
Hyporesponsive to stimuli 15.44 10.50 15 72966 983 31623380
Stupor 15.44 10.50 25 72956 2759 31621604
Drug dispensed to wrong patient 15.40 10.50 11 72970 468 31623895
Dissociation 15.39 10.50 17 72964 1295 31623068
Sleep deficit 15.38 10.50 11 72970 469 31623894
Loss of proprioception 15.36 10.50 10 72971 365 31623998
Potentiating drug interaction 15.33 10.50 33 72948 4520 31619843
Small for dates baby 15.30 10.50 29 72952 3626 31620737
Neonatal respiratory distress syndrome 15.25 10.50 30 72951 3855 31620508
Skin lesion inflammation 15.23 10.50 3 72978 0 31624363
Blood ethanol increased 15.16 10.50 11 72970 480 31623883
Neonatal hyponatraemia 15.16 10.50 6 72975 73 31624290
Balance disorder 15.13 10.50 142 72839 37280 31587083
Neutrophil count increased 15.10 10.50 74 72907 15657 31608706
Oedema peripheral 15.03 10.50 171 72810 109668 31514695
Brain oedema 15.02 10.50 64 72917 12768 31611595
Chest pain 14.88 10.50 185 72796 116772 31507591
Basal cell carcinoma 14.87 10.50 12 72969 18167 31606196
Appendicitis 14.85 10.50 4 72977 11461 31612902
Self esteem decreased 14.65 10.50 11 72970 506 31623857
Respiratory rate decreased 14.64 10.50 21 72960 2084 31622279
Mumps 14.60 10.50 6 72975 81 31624282
Rapid eye movement sleep behaviour disorder 14.59 10.50 7 72974 139 31624224
Paradoxical drug reaction 14.58 10.50 26 72955 3103 31621260
Pancytopenia 14.40 10.50 130 72851 87186 31537177
Suspiciousness 14.34 10.50 9 72972 308 31624055
Fear 14.30 10.50 53 72928 9921 31614442
Feeling abnormal 14.29 10.50 197 72784 56805 31567558
Sensory disturbance 14.28 10.50 37 72944 5710 31618653
Abulia 14.26 10.50 11 72970 527 31623836
Autoscopy 14.23 10.50 7 72974 147 31624216
Sinus tachycardia 14.12 10.50 73 72908 15776 31608587
Splenomegaly 14.10 10.50 7 72974 13742 31610621
Product use issue 14.06 10.50 75 72906 56684 31567679
Housebound 14.00 10.50 8 72973 230 31624133
Abnormal dreams 13.95 10.50 42 72939 7066 31617297
Rash erythematous 13.94 10.50 19 72962 22608 31601755
Xanthoma 13.91 10.50 6 72975 92 31624271
Bronchopulmonary aspergillosis 13.89 10.50 7 72974 13627 31610736
Anaemia 13.84 10.50 380 72601 213142 31411221
Lung disorder 13.78 10.50 34 72947 32278 31592085
Failure to thrive 13.75 10.50 45 72936 7917 31616446
Nasal congestion 13.72 10.50 16 72965 20365 31603998
COVID-19 pneumonia 13.66 10.50 6 72975 12649 31611714
Spinal cord injury thoracic 13.62 10.50 6 72975 97 31624266
Limited symptom panic attack 13.60 10.50 5 72976 49 31624314
Non-alcoholic steatohepatitis 13.52 10.50 13 72968 841 31623522
Renal disorder 13.44 10.50 21 72960 23624 31600739
Drug reaction with eosinophilia and systemic symptoms 13.27 10.50 31 72950 29987 31594376
Accidental poisoning 13.26 10.50 12 72969 719 31623644
Locked-in syndrome 13.23 10.50 8 72973 256 31624107
Sepsis neonatal 13.09 10.50 8 72973 261 31624102
Alcohol poisoning 13.08 10.50 25 72956 3146 31621217
Behaviour disorder 12.94 10.50 30 72951 4317 31620046
Mitral valve sclerosis 12.94 10.50 6 72975 110 31624253
Blood pressure increased 12.94 10.50 119 72862 79514 31544849
Bacteraemia 12.80 10.50 13 72968 17621 31606742
Insulin resistance 12.80 10.50 11 72970 615 31623748
Fungal infection 12.68 10.50 9 72972 14542 31609821
Pneumocystis jirovecii pneumonia 12.64 10.50 14 72967 18237 31606126
Gastrointestinal disorder 12.51 10.50 33 72948 30627 31593736
Pelvic fracture 12.48 10.50 21 72960 2392 31621971
Cytokine release syndrome 12.39 10.50 12 72969 16630 31607733
Renal impairment 12.38 10.50 133 72848 86216 31538147
Consciousness fluctuating 12.36 10.50 14 72967 1097 31623266
Fluid retention 12.31 10.50 24 72957 24778 31599585
Polypectomy 12.29 10.50 10 72971 518 31623845
Stoma site discharge 12.28 10.50 13 72968 944 31623419
Acute pulmonary oedema 12.22 10.50 40 72941 7036 31617327
Light chain disease 12.16 10.50 6 72975 127 31624236
Initial insomnia 12.08 10.50 23 72958 2886 31621477
Bronchitis 12.07 10.50 47 72934 38670 31585693
Inferior vena caval occlusion 12.05 10.50 4 72977 28 31624335
Angina pectoris 12.02 10.50 32 72949 29609 31594754
Hepatic failure 12.02 10.50 37 72944 32665 31591698
Respiratory tract haemorrhage 11.95 10.50 14 72967 1137 31623226
Hepatic steatosis 11.93 10.50 71 72910 16168 31608195
Electric shock 11.87 10.50 6 72975 134 31624229
Rash maculo-papular 11.82 10.50 26 72955 25693 31598670
Infection 11.82 10.50 126 72855 81805 31542558
Hyperthermia 11.79 10.50 50 72931 9954 31614409
Dyspnoea 11.78 10.50 659 72322 342820 31281543
Cerebellar ataxia 11.76 10.50 13 72968 991 31623372
Pneumonitis 11.75 10.50 34 72947 30618 31593745
Body temperature abnormal 11.74 10.50 10 72971 552 31623811
Staphylococcal infection 11.73 10.50 34 72947 30598 31593765
Dysaesthesia 11.71 10.50 19 72962 2100 31622263
Bladder dilatation 11.67 10.50 15 72966 1341 31623022
Erectile dysfunction 11.60 10.50 80 72901 19155 31605208
Radial nerve injury 11.48 10.50 4 72977 33 31624330
Coma scale abnormal 11.42 10.50 26 72955 3697 31620666
Psychotic symptom 11.40 10.50 16 72965 1556 31622807
Pseudomonas infection 11.40 10.50 6 72975 11395 31612968
Hypertension 11.39 10.50 217 72764 127883 31496480
Agitated depression 11.38 10.50 7 72974 231 31624132
Nephropathy toxic 11.31 10.50 6 72975 11347 31613016
Blood pressure fluctuation 11.28 10.50 22 72959 22714 31601649
Formication 11.28 10.50 16 72965 1571 31622792
Panic disorder 11.28 10.50 14 72967 1208 31623155
Shock 11.16 10.50 22 72959 22623 31601740
Hypotonia 11.16 10.50 39 72942 7094 31617269
Tension 11.14 10.50 18 72963 1983 31622380
Gallbladder enlargement 11.10 10.50 13 72968 1056 31623307
Hypersensitivity 11.03 10.50 79 72902 55664 31568699
Pneumonia bacterial 10.93 10.50 5 72976 10291 31614072
Serum serotonin increased 10.92 10.50 5 72976 89 31624274
Respiratory failure 10.92 10.50 166 72815 101283 31523080
Skin cancer 10.86 10.50 4 72977 9381 31614982
Kidney congestion 10.84 10.50 7 72974 252 31624111
Mutism 10.80 10.50 11 72970 763 31623600
Influenza 10.74 10.50 59 72922 44266 31580097
Stoma site induration 10.72 10.50 4 72977 41 31624322
JC polyomavirus test positive 10.72 10.50 10 72971 623 31623740
Drug abuser 10.71 10.50 26 72955 3854 31620509
Feeling of despair 10.70 10.50 12 72969 930 31623433
Frequent bowel movements 10.68 10.50 5 72976 10154 31614209
Hypertrophic scar 10.63 10.50 3 72978 11 31624352
Jealous delusion 10.62 10.50 7 72974 261 31624102
Neoplasm progression 10.60 10.50 19 72962 20253 31604110
Thrombotic stroke 10.60 10.50 7 72974 262 31624101
Rebound effect 10.59 10.50 20 72961 2493 31621870
Respiratory acidosis 10.56 10.50 29 72952 4633 31619730
Cellulitis 10.52 10.50 66 72915 47952 31576411

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 968.32 9.89 2370 150305 379802 70395967
Intentional overdose 833.51 9.89 1043 151632 97392 70678377
Serotonin syndrome 778.01 9.89 678 151997 41436 70734333
Suicide attempt 756.81 9.89 894 151781 78616 70697153
Drug abuse 678.63 9.89 1171 151504 146085 70629684
Completed suicide 676.09 9.89 1502 151173 225633 70550136
Intentional self-injury 655.07 9.89 544 152131 31106 70744663
Suicidal ideation 588.16 9.89 737 151938 68859 70706910
Sopor 548.65 9.89 489 152186 30778 70744991
Overdose 467.37 9.89 1089 151586 168656 70607113
Somnolence 451.65 9.89 1247 151428 214359 70561410
Agitation 451.53 9.89 759 151916 92616 70683153
Rheumatoid arthritis 399.01 9.89 73 152602 291732 70484037
Drug interaction 396.74 9.89 1748 150927 379693 70396076
Electrocardiogram QT prolonged 376.29 9.89 658 152017 82859 70692910
Confusional state 346.05 9.89 1368 151307 283030 70492739
Hyponatraemia 290.59 9.89 880 151795 159207 70616562
Coma 288.08 9.89 621 152054 91223 70684546
Depression 285.02 9.89 1009 151666 197965 70577804
Restlessness 281.67 9.89 398 152277 41730 70734039
Anxiety 254.31 9.89 1043 151632 219287 70556482
Fall 245.23 9.89 1715 150960 442381 70333388
Neuroleptic malignant syndrome 244.82 9.89 291 152384 25716 70750053
Disorientation 243.66 9.89 443 152232 57480 70718289
Tremor 240.92 9.89 810 151865 154814 70620955
Restless legs syndrome 231.83 9.89 240 152435 18188 70757581
Infusion related reaction 223.97 9.89 73 152602 197461 70578308
Synovitis 216.70 9.89 16 152659 129212 70646557
Joint swelling 209.90 9.89 144 152531 253067 70522702
Inappropriate antidiuretic hormone secretion 206.93 9.89 253 152422 23023 70752746
Depressed level of consciousness 206.30 9.89 529 152146 86902 70688867
Aggression 201.82 9.89 369 152306 48077 70727692
Akathisia 201.31 9.89 185 152490 12108 70763661
Delirium 201.00 9.89 475 152200 74139 70701630
Disturbance in attention 197.05 9.89 341 152334 42553 70733216
Nightmare 194.01 9.89 239 152436 21917 70753852
Muscle rigidity 191.11 9.89 218 152457 18432 70757337
Depressed mood 187.91 9.89 338 152337 43482 70732287
Drug withdrawal syndrome 184.01 9.89 285 152390 32430 70743339
Arthropathy 183.74 9.89 48 152627 150009 70625760
Extrapyramidal disorder 177.14 9.89 221 152454 20529 70755240
Rash 174.18 9.89 543 152132 510019 70265750
Nasopharyngitis 170.40 9.89 137 152538 222069 70553700
Hallucination, visual 165.59 9.89 256 152419 29081 70746688
Tachycardia 164.55 9.89 727 151948 157819 70617950
Systemic lupus erythematosus 161.59 9.89 16 152659 101886 70673883
Dyskinesia 158.77 9.89 303 152372 40771 70734998
Mania 156.44 9.89 189 152486 16985 70758784
Sinusitis 155.77 9.89 85 152590 169110 70606659
Withdrawal syndrome 152.89 9.89 226 152449 24678 70751091
Arthralgia 152.84 9.89 563 152112 502827 70272942
Psychotic disorder 150.54 9.89 282 152393 37419 70738350
Depersonalisation/derealisation disorder 147.25 9.89 73 152602 1675 70774094
Pemphigus 145.98 9.89 8 152667 83028 70692741
Accidental overdose 145.62 9.89 267 152408 34854 70740915
Dissociation 143.77 9.89 90 152585 3286 70772483
Swelling 137.46 9.89 122 152553 188417 70587352
Drug hypersensitivity 135.04 9.89 223 152452 262236 70513533
Parkinsonism 133.67 9.89 165 152510 15160 70760609
Glossodynia 131.00 9.89 16 152659 86471 70689298
Sedation 127.45 9.89 299 152376 46432 70729337
Urinary retention 126.15 9.89 320 152355 52200 70723569
Hallucination 126.00 9.89 406 152269 75854 70699915
Peripheral swelling 125.45 9.89 197 152478 236366 70539403
Hallucination, auditory 125.21 9.89 175 152500 18153 70757616
Alopecia 124.74 9.89 146 152529 198344 70577425
Drug ineffective 121.16 9.89 1368 151307 938384 69837385
Therapeutic product effect decreased 120.21 9.89 80 152595 142938 70632831
Poisoning 120.17 9.89 192 152483 22430 70753339
Derealisation 120.14 9.89 61 152614 1475 70774294
Cogwheel rigidity 118.60 9.89 76 152599 2892 70772877
Abdominal discomfort 118.40 9.89 174 152501 214484 70561285
Treatment failure 118.00 9.89 83 152592 144059 70631710
General physical health deterioration 116.93 9.89 889 151786 235142 70540627
Myoclonus 115.17 9.89 205 152470 26150 70749619
Dystonia 112.66 9.89 173 152502 19533 70756236
Loss of consciousness 112.04 9.89 644 152031 155072 70620697
Pain 110.81 9.89 846 151829 627970 70147799
Hyperhidrosis 110.73 9.89 568 152107 131018 70644751
Dysarthria 109.59 9.89 339 152336 61974 70713795
Contraindicated product administered 109.54 9.89 78 152597 134534 70641235
Intrusive thoughts 108.99 9.89 39 152636 378 70775391
Mydriasis 108.51 9.89 153 152522 16000 70759769
Drug intolerance 106.80 9.89 202 152473 225485 70550284
Progressive multifocal leukoencephalopathy 104.71 9.89 165 152510 19049 70756720
Gastric pH decreased 104.23 9.89 45 152630 743 70775026
Hypersensitivity 104.16 9.89 211 152464 229601 70546168
Helicobacter infection 102.25 9.89 4 152671 55652 70720117
Feeling of despair 101.29 9.89 66 152609 2585 70773184
Mood swings 96.86 9.89 155 152520 18131 70757638
Pericarditis 96.48 9.89 31 152644 84674 70691095
Psychomotor hyperactivity 96.09 9.89 141 152534 15292 70760477
Urticaria 96.06 9.89 126 152549 162923 70612846
Injection site pain 94.59 9.89 69 152606 117550 70658219
Major depression 94.30 9.89 104 152571 8470 70767299
Seizure 93.02 9.89 679 151996 177283 70598486
Cough 92.73 9.89 373 152302 325004 70450765
Pleurothotonus 88.19 9.89 58 152617 2308 70773461
Abnormal behaviour 88.09 9.89 216 152459 34493 70741276
Febrile neutropenia 87.22 9.89 194 152481 204124 70571645
Poisoning deliberate 86.81 9.89 142 152533 16918 70758851
Tardive dyskinesia 85.14 9.89 106 152569 9823 70765946
Paranoia 84.08 9.89 141 152534 17147 70758622
Altered state of consciousness 84.05 9.89 232 152443 39790 70735979
Pneumonia aspiration 84.01 9.89 310 152365 61979 70713790
Arthritis 80.72 9.89 56 152619 97924 70677845
Hypertonia 80.59 9.89 84 152591 6414 70769355
Pruritus 80.16 9.89 427 152248 345133 70430636
Drug dependence 80.03 9.89 218 152457 37103 70738666
Feeling jittery 80.02 9.89 111 152564 11432 70764337
Delusion 79.82 9.89 146 152529 19019 70756750
Product use issue 79.15 9.89 168 152507 179769 70596000
Sleep disorder 79.03 9.89 329 152346 69543 70706226
Bradyphrenia 78.67 9.89 102 152573 9844 70765925
Folliculitis 78.40 9.89 3 152672 42567 70733202
Impaired healing 78.25 9.89 31 152644 74343 70701426
Anger 77.69 9.89 131 152544 16001 70759768
Logorrhoea 77.45 9.89 67 152608 4047 70771722
Psoriatic arthropathy 76.84 9.89 22 152653 64749 70711020
Product prescribing error 76.13 9.89 220 152455 38732 70737037
Depressive symptom 75.32 9.89 73 152602 5108 70770661
On and off phenomenon 75.12 9.89 56 152619 2730 70773039
Off label use 74.45 9.89 1139 151536 741921 70033848
Duodenal ulcer perforation 73.72 9.89 11 152664 51101 70724668
Rhabdomyolysis 72.77 9.89 402 152273 95358 70680411
Asphyxia 72.51 9.89 100 152575 10242 70765527
Insomnia 71.94 9.89 751 151924 217055 70558714
Hallucinations, mixed 71.41 9.89 78 152597 6284 70769485
Homicidal ideation 70.55 9.89 58 152617 3265 70772504
Irritability 70.04 9.89 211 152464 38014 70737755
Respiratory arrest 69.06 9.89 264 152411 53669 70722100
Discomfort 68.99 9.89 75 152600 105361 70670408
Speech disorder 68.43 9.89 252 152423 50328 70725441
Panic attack 67.50 9.89 148 152527 21971 70753798
Bradykinesia 67.41 9.89 82 152593 7420 70768349
Systemic infection 66.82 9.89 77 152598 6580 70769189
Asthma 66.47 9.89 98 152577 120695 70655074
Irritable bowel syndrome 64.67 9.89 15 152660 50835 70724934
Intentional product use issue 64.63 9.89 99 152576 120043 70655726
Incontinence 64.35 9.89 107 152568 12921 70762848
Miosis 63.30 9.89 111 152564 13990 70761779
Wrong patient received product 63.03 9.89 62 152613 4418 70771351
Hepatic enzyme increased 62.23 9.89 155 152520 156835 70618934
Abnormal dreams 61.90 9.89 94 152581 10509 70765260
Stomatitis 61.65 9.89 114 152561 128397 70647372
Myocardial infarction 61.60 9.89 178 152497 171467 70604302
Substance abuse 61.42 9.89 90 152585 9747 70766022
Antidepressant drug level above therapeutic 61.31 9.89 29 152646 598 70775171
Tachyphrenia 61.23 9.89 43 152632 1908 70773861
Respiratory depression 60.34 9.89 152 152523 24679 70751090
Loss of libido 60.30 9.89 47 152628 2450 70773319
Infection 59.13 9.89 243 152432 210542 70565227
Interstitial lung disease 58.51 9.89 84 152591 104601 70671168
Drooling 58.17 9.89 65 152610 5371 70770398
Illusion 57.81 9.89 39 152636 1620 70774149
Injection site pruritus 57.57 9.89 8 152667 39202 70736567
Injection site erythema 57.05 9.89 44 152631 72880 70702889
Blister 56.84 9.89 80 152595 100446 70675323
Nasal congestion 56.16 9.89 36 152639 65636 70710133
Feeling of body temperature change 55.81 9.89 61 152614 4918 70770851
H1N1 influenza 55.59 9.89 44 152631 2346 70773423
Apathy 55.10 9.89 95 152580 11813 70763956
Erythema 54.77 9.89 232 152443 199331 70576438
Product administration error 54.12 9.89 163 152512 29360 70746409
Gastrointestinal disorder 53.76 9.89 90 152585 105337 70670432
Urinary hesitation 53.55 9.89 52 152623 3647 70772122
Psoriasis 53.05 9.89 81 152594 98352 70677417
Knee arthroplasty 52.79 9.89 6 152669 34295 70741474
Pain in extremity 51.83 9.89 454 152221 327628 70448141
Persecutory delusion 51.78 9.89 56 152619 4461 70771308
Muscle injury 51.73 9.89 10 152665 38484 70737285
Psychomotor retardation 51.62 9.89 62 152613 5536 70770233
Parosmia 51.12 9.89 58 152617 4873 70770896
Cardiac arrest 49.88 9.89 545 152130 159289 70616480
Intentional product misuse 49.45 9.89 317 152358 79278 70696491
Mental disorder 49.04 9.89 153 152522 28087 70747682
Circulatory collapse 49.04 9.89 178 152497 35296 70740473
Pneumonia 48.61 9.89 948 151727 595284 70180485
Intestinal pseudo-obstruction 48.07 9.89 40 152635 2290 70773479
Back pain 47.95 9.89 364 152311 270788 70504981
Schizophrenia 47.58 9.89 109 152566 16659 70759110
Lower respiratory tract infection 47.12 9.89 107 152568 111806 70663963
Osteoarthritis 47.12 9.89 54 152621 74093 70701676
Myelosuppression 47.08 9.89 5 152670 30140 70745629
Herpes zoster 47.04 9.89 69 152606 85166 70690603
Product monitoring error 46.73 9.89 65 152610 6711 70769058
Platelet count decreased 46.59 9.89 211 152464 178011 70597758
Acute psychosis 45.68 9.89 49 152626 3867 70771902
Maternal exposure during pregnancy 45.61 9.89 114 152561 115231 70660538
Helplessness 45.42 9.89 20 152655 347 70775422
Aptyalism 45.37 9.89 25 152650 717 70775052
Cytomegalovirus infection 44.48 9.89 15 152660 39743 70736026
Pyrexia 44.18 9.89 983 151692 605969 70169800
Cardiac failure congestive 43.97 9.89 147 152528 135310 70640459
Epilepsy 43.36 9.89 182 152493 38602 70737167
Injection site bruising 43.16 9.89 14 152661 38018 70737751
Abulia 42.54 9.89 26 152649 909 70774860
Galactorrhoea 42.49 9.89 44 152631 3334 70772435
Menstrual disorder 42.06 9.89 45 152630 3541 70772228
Priapism 42.03 9.89 48 152627 4062 70771707
Hyperkinesia 42.02 9.89 39 152636 2584 70773185
Fatigue 41.88 9.89 1405 151270 822914 69952855
Incoherent 41.56 9.89 64 152611 7242 70768527
Unresponsive to stimuli 41.46 9.89 221 152454 51710 70724059
Antipsychotic drug level above therapeutic 40.89 9.89 34 152641 1945 70773824
Injection site swelling 40.69 9.89 21 152654 43136 70732633
Analgesic drug level above therapeutic 40.53 9.89 20 152655 454 70775315
Bronchitis 39.60 9.89 125 152550 117118 70658651
Polydipsia 39.16 9.89 56 152619 5932 70769837
Wound 38.71 9.89 98 152577 98634 70677135
Syncope 38.68 9.89 535 152140 165174 70610595
Blood prolactin increased 38.65 9.89 44 152631 3710 70772059
Impulsive behaviour 38.53 9.89 38 152637 2716 70773053
Abnormal weight gain 38.33 9.89 35 152640 2271 70773498
Coma scale abnormal 37.88 9.89 65 152610 8051 70767718
Thrombocytopenia 37.68 9.89 331 152344 238779 70536990
Neuropathy peripheral 37.66 9.89 143 152532 126753 70649016
Therapeutic product ineffective 37.46 9.89 30 152645 1627 70774142
Fungal infection 37.20 9.89 17 152658 37450 70738319
Activation syndrome 37.18 9.89 16 152659 262 70775507
Device expulsion 36.58 9.89 3 152672 22243 70753526
Upper respiratory tract infection 36.54 9.89 72 152603 79202 70696567
Accidental death 35.57 9.89 43 152632 3865 70771904
COVID-19 35.54 9.89 113 152562 105644 70670125
Suspected suicide 35.15 9.89 66 152609 8768 70767001
Septic shock 34.96 9.89 124 152551 112134 70663635
Ill-defined disorder 34.64 9.89 40 152635 54701 70721068
Muscle disorder 34.37 9.89 49 152626 5176 70770593
Hip arthroplasty 34.24 9.89 9 152666 28031 70747738
Social avoidant behaviour 34.12 9.89 46 152629 4610 70771159
Osteoporosis 34.01 9.89 33 152642 48874 70726895
Hyperreflexia 33.95 9.89 59 152616 7383 70768386
Catatonia 33.92 9.89 62 152613 8071 70767698
Acute motor-sensory axonal neuropathy 33.86 9.89 17 152658 401 70775368
Feelings of worthlessness 33.75 9.89 18 152657 483 70775286
Fracture 33.66 9.89 107 152568 19837 70755932
Hypotonia 33.52 9.89 77 152598 11788 70763981
Anaphylactic shock 33.43 9.89 14 152661 32476 70743293
Blood pressure increased 33.34 9.89 253 152422 188264 70587505
Inflammation 33.28 9.89 75 152600 78590 70697179
Pallor 33.13 9.89 175 152500 40799 70734970
Muscle twitching 33.13 9.89 106 152569 19721 70756048
Diarrhoea 32.86 9.89 1366 151309 781975 69993794
Merycism 32.60 9.89 14 152661 228 70775541
Dysphagia 32.59 9.89 379 152296 112455 70663314
Illness anxiety disorder 32.27 9.89 14 152661 234 70775535
Cognitive disorder 32.04 9.89 233 152442 60723 70715046
Gestational diabetes 31.96 9.89 51 152624 5950 70769819
Headache 31.86 9.89 979 151696 579426 70196343
Bursitis 31.74 9.89 9 152666 26664 70749105
Cataract 31.73 9.89 44 152631 55601 70720168
Bipolar disorder 31.73 9.89 58 152617 7550 70768219
Rhinorrhoea 31.71 9.89 59 152616 66312 70709457
Generalised tonic-clonic seizure 31.70 9.89 175 152500 41486 70734283
Product dose omission issue 31.26 9.89 308 152367 217160 70558609
Hyponatraemic coma 30.95 9.89 9 152666 41 70775728
Electrocardiogram abnormal 30.78 9.89 85 152590 14579 70761190
Acute myeloid leukaemia 30.77 9.89 14 152661 30926 70744843
Hypoaesthesia oral 30.63 9.89 76 152599 12224 70763545
Pressure of speech 30.61 9.89 22 152653 1013 70774756
Decreased gait velocity 30.60 9.89 12 152663 153 70775616
Thinking abnormal 30.58 9.89 75 152600 11976 70763793
Mental impairment 30.44 9.89 94 152581 17161 70758608
Sleep paralysis 30.41 9.89 18 152657 593 70775176
Hypomania 30.16 9.89 50 152625 6022 70769747
Bradypnoea 29.91 9.89 47 152628 5412 70770357
Panic reaction 29.50 9.89 41 152634 4230 70771539
Feeling guilty 29.43 9.89 20 152655 841 70774928
Parkinsonian gait 29.37 9.89 20 152655 844 70774925
Blood creatine phosphokinase increased 29.29 9.89 229 152446 61034 70714735
JC virus infection 29.00 9.89 37 152638 3514 70772255
Hyperthermia 28.65 9.89 90 152585 16581 70759188
Multiple organ dysfunction syndrome 28.63 9.89 128 152547 108387 70667382
Platypnoea 28.34 9.89 8 152667 32 70775737
Sepsis 28.20 9.89 364 152311 244181 70531588
Sarcopenia 27.94 9.89 15 152660 408 70775361
Thrombotic microangiopathy 27.77 9.89 3 152672 17845 70757924
Language disorder 27.64 9.89 33 152642 2928 70772841
Serum serotonin increased 27.53 9.89 13 152662 267 70775502
Sinus tachycardia 27.53 9.89 145 152530 33768 70742001
Nephrolithiasis 27.41 9.89 37 152638 47286 70728483
Mutism 27.41 9.89 28 152647 2088 70773681
Antipsychotic drug level increased 27.29 9.89 45 152630 5395 70770374
Ejaculation failure 27.22 9.89 14 152661 348 70775421
Posture abnormal 27.08 9.89 36 152639 3560 70772209
Blood pressure diastolic decreased 26.70 9.89 11 152664 25769 70750000
Palmar-plantar erythrodysaesthesia syndrome 26.66 9.89 16 152659 30231 70745538
Phagophobia 26.58 9.89 8 152667 42 70775727
Tonic clonic movements 26.58 9.89 27 152648 2000 70773769
Chest pain 26.45 9.89 381 152294 250879 70524890
Fluid retention 26.35 9.89 61 152614 63324 70712445
Medication error 26.25 9.89 211 152464 56701 70719068
Balance disorder 26.14 9.89 303 152372 89825 70685944
Pleural effusion 26.07 9.89 173 152502 132691 70643078
Ataxia 25.99 9.89 109 152566 23108 70752661
Crush syndrome 25.62 9.89 11 152664 179 70775590
Wrong product administered 25.62 9.89 56 152619 8295 70767474
Rash erythematous 25.58 9.89 45 152630 51673 70724096
Basal cell carcinoma 25.51 9.89 21 152654 33677 70742092
Disease progression 25.51 9.89 215 152460 156457 70619312
Sudden death 25.24 9.89 101 152574 20963 70754806
Macrophages increased 24.82 9.89 11 152664 194 70775575
Mood altered 24.78 9.89 85 152590 16390 70759379
Benign gastrointestinal neoplasm 24.72 9.89 10 152665 139 70775630
Blood pressure systolic increased 24.70 9.89 54 152621 57205 70718564
Akinesia 24.59 9.89 32 152643 3099 70772670
Euphoric mood 24.40 9.89 49 152626 6840 70768929
Somnambulism 24.38 9.89 42 152633 5218 70770551
Agranulocytosis 24.11 9.89 159 152516 40139 70735630
False positive investigation result 24.10 9.89 18 152657 880 70774889
Atrial fibrillation 24.08 9.89 267 152408 184081 70591688
Productive cough 24.07 9.89 87 152588 78250 70697519
Erectile dysfunction 24.03 9.89 74 152601 13488 70762281
Formication 24.01 9.89 39 152636 4618 70771151
Tumour lysis syndrome 23.99 9.89 8 152667 21352 70754417
Heart rate decreased 23.96 9.89 62 152613 61953 70713816
Stoma site discharge 23.88 9.89 24 152651 1755 70774014
Transplant rejection 23.83 9.89 5 152670 18166 70757603
Premature labour 23.81 9.89 53 152622 7947 70767822
Urogenital haemorrhage 23.76 9.89 17 152658 777 70774992
Increased appetite 23.76 9.89 63 152612 10550 70765219
Inappropriate schedule of product administration 23.73 9.89 135 152540 107420 70668349
Chemical burn of oral cavity 23.71 9.89 8 152667 64 70775705
Suicidal behaviour 23.64 9.89 31 152644 3025 70772744
Rhonchi 23.63 9.89 34 152641 3621 70772148
Pulmonary congestion 23.56 9.89 112 152563 25042 70750727
Cardio-respiratory arrest 23.46 9.89 325 152350 100352 70675417
Pyroglutamic acidosis 22.96 9.89 17 152658 820 70774949
Hyporesponsive to stimuli 22.93 9.89 24 152651 1841 70773928
Norepinephrine increased 22.88 9.89 8 152667 72 70775697
Alcohol use 22.85 9.89 38 152637 4589 70771180
Affective disorder 22.77 9.89 50 152625 7429 70768340
Stupor 22.70 9.89 46 152629 6463 70769306
Anticholinergic syndrome 22.70 9.89 30 152645 2950 70772819
IVth nerve disorder 22.58 9.89 6 152669 18 70775751
Therapeutic product effect incomplete 22.57 9.89 158 152517 119724 70656045
Dyspnoea 22.57 9.89 1393 151282 768667 70007102
Chorea 22.50 9.89 25 152650 2053 70773716
Hypophagia 22.48 9.89 160 152515 41410 70734359
Histrionic personality disorder 22.47 9.89 7 152668 42 70775727
Ejaculation disorder 22.39 9.89 14 152661 510 70775259
Gastrooesophageal reflux disease 22.28 9.89 110 152565 90729 70685040
Malignant neoplasm progression 22.17 9.89 162 152513 121577 70654192
Bulimia nervosa 22.16 9.89 11 152664 253 70775516
Gait disturbance 22.07 9.89 538 152137 184568 70591201
Myelodysplastic syndrome 22.01 9.89 19 152656 29766 70746003
Potentiating drug interaction 21.99 9.89 52 152623 8112 70767657
Anaphylactic reaction 21.91 9.89 85 152590 74889 70700880
Oesophageal obstruction 21.83 9.89 17 152658 885 70774884
Injection site haemorrhage 21.81 9.89 14 152661 25513 70750256
Mucosal inflammation 21.76 9.89 74 152601 67776 70707993
Delusion of grandeur 21.74 9.89 17 152658 890 70774879
Electrocardiogram QRS complex prolonged 21.74 9.89 58 152617 9748 70766021
Stoma site infection 21.72 9.89 20 152655 1312 70774457
Glassy eyes 21.57 9.89 9 152666 136 70775633
Thirst 21.52 9.89 75 152600 14574 70761195
Opisthotonus 21.33 9.89 15 152660 667 70775102
Food craving 21.30 9.89 21 152654 1500 70774269
Alcoholism 21.27 9.89 36 152639 4409 70771360
Joint range of motion decreased 21.26 9.89 15 152660 26011 70749758
Psychiatric decompensation 21.12 9.89 29 152646 2958 70772811
Neglect of personal appearance 21.10 9.89 9 152666 144 70775625
Acute myocardial infarction 21.06 9.89 83 152592 72804 70702965
Haematemesis 20.95 9.89 178 152497 48619 70727150
Sensory loss 20.88 9.89 63 152612 11356 70764413
Psychotic symptom 20.86 9.89 26 152649 2412 70773357
Injection site reaction 20.70 9.89 48 152627 49804 70725965
Cytokine release syndrome 20.66 9.89 16 152659 26451 70749318
Prostate cancer 20.56 9.89 22 152653 31141 70744628
Dementia 20.53 9.89 99 152576 22266 70753503
Tendonitis 20.50 9.89 11 152664 22111 70753658
Osteomyelitis 20.46 9.89 21 152654 30297 70745472
Influenza 20.37 9.89 152 152523 113548 70662221
Skin necrosis 20.33 9.89 5 152670 16286 70759483
Hanging 20.33 9.89 8 152667 103 70775666
Vestibular disorder 20.26 9.89 25 152650 2295 70773474
Congenital cerebrovascular anomaly 20.25 9.89 5 152670 10 70775759
Bladder cancer 20.18 9.89 6 152669 17236 70758533
Sudden cardiac death 20.07 9.89 37 152638 4848 70770921
Obsessive-compulsive disorder 19.99 9.89 39 152636 5331 70770438
Conjunctivitis 19.91 9.89 12 152663 22624 70753145
Hallucination, synaesthetic 19.83 9.89 7 152668 65 70775704
Postictal state 19.79 9.89 21 152654 1637 70774132
Pulmonary arterial hypertension 19.73 9.89 25 152650 32830 70742939
Faecaloma 19.43 9.89 58 152617 10393 70765376
Rapid eye movements sleep abnormal 19.43 9.89 10 152665 249 70775520
CYP3A4 polymorphism 19.37 9.89 7 152668 70 70775699
Sleep terror 19.34 9.89 18 152657 1197 70774572
Amnesia 19.19 9.89 184 152491 51971 70723798
Fibromyalgia 19.16 9.89 47 152628 47827 70727942
Cold sweat 19.13 9.89 80 152595 16936 70758833
Hypersomnia 19.12 9.89 92 152583 20672 70755097
Failure to thrive 19.11 9.89 59 152616 10770 70764999
Obsessive-compulsive personality disorder 19.10 9.89 8 152667 122 70775647
Oropharyngeal pain 19.09 9.89 125 152550 96185 70679584
Aspiration 19.02 9.89 82 152593 17593 70758176
Treatment noncompliance 19.00 9.89 168 152507 46406 70729363
White blood cell count decreased 18.96 9.89 255 152420 169886 70605883
Breast discomfort 18.87 9.89 11 152664 352 70775417
Blood bilirubin decreased 18.86 9.89 16 152659 941 70774828
Emotional disorder 18.82 9.89 67 152608 13159 70762610
Alcohol interaction 18.81 9.89 35 152640 4618 70771151
Labelled drug-drug interaction medication error 18.79 9.89 102 152573 24025 70751744
Bezoar 18.79 9.89 24 152651 2282 70773487
Paralysis 18.78 9.89 63 152612 12009 70763760
Hypervigilance 18.72 9.89 12 152663 457 70775312
Cyanosis 18.68 9.89 99 152576 23107 70752662
Self-injurious ideation 18.65 9.89 29 152646 3309 70772460
Sexual dysfunction 18.48 9.89 43 152632 6638 70769131
Coronary artery disease 18.41 9.89 71 152604 62665 70713104
Binge eating 18.30 9.89 12 152663 475 70775294
Pseudomonas infection 18.27 9.89 9 152666 18985 70756784
Osteonecrosis of jaw 18.24 9.89 38 152637 40964 70734805
Thymus disorder 18.23 9.89 10 152665 284 70775485
Tracheal pain 18.23 9.89 6 152669 44 70775725
Amnestic disorder 18.21 9.89 13 152662 592 70775177
Respiratory rate decreased 18.13 9.89 35 152640 4747 70771022
Sputum discoloured 18.03 9.89 9 152666 18842 70756927
Stoma site inflammation 18.02 9.89 13 152662 602 70775167
Autonomic nervous system imbalance 18.00 9.89 33 152642 4306 70771463
Decreased interest 17.99 9.89 29 152646 3412 70772357
Salivary hypersecretion 17.98 9.89 65 152610 12860 70762909
Decreased appetite 17.95 9.89 815 151860 303965 70471804
Sensory disturbance 17.94 9.89 68 152607 13764 70762005
Natural killer cell count decreased 17.89 9.89 6 152669 47 70775722
Patient elopement 17.89 9.89 6 152669 47 70775722
Red blood cell sedimentation rate increased 17.89 9.89 35 152640 38607 70737162
Negative thoughts 17.73 9.89 18 152657 1332 70774437
Eosinophilic pleural effusion 17.71 9.89 10 152665 301 70775468
Drug dose titration not performed 17.71 9.89 14 152661 745 70775024
Dementia with Lewy bodies 17.68 9.89 14 152661 747 70775022
Skin lesion 17.66 9.89 35 152640 38425 70737344
Ear infection 17.61 9.89 21 152654 28315 70747454
Mitral valve incompetence 17.49 9.89 19 152656 26709 70749060
Postoperative respiratory failure 17.41 9.89 8 152667 154 70775615
Oedema 17.37 9.89 141 152534 103440 70672329
Postmortem blood drug level increased 17.32 9.89 14 152661 769 70775000
Disinhibition 17.27 9.89 23 152652 2278 70773491
Haemoptysis 17.26 9.89 55 152620 51397 70724372
JC virus CSF test positive 17.23 9.89 8 152667 158 70775611
Communication disorder 17.20 9.89 30 152645 3764 70772005
Drowning 17.18 9.89 14 152661 778 70774991
Blood sodium decreased 17.17 9.89 120 152555 30878 70744891
Psychomotor skills impaired 17.04 9.89 32 152643 4252 70771517
Clonus 16.97 9.89 40 152635 6228 70769541
Immune reconstitution inflammatory syndrome 16.96 9.89 64 152611 12926 70762843
Antidepressant drug level decreased 16.92 9.89 4 152671 6 70775763
Reduced facial expression 16.88 9.89 23 152652 2329 70773440
Nasal discomfort 16.83 9.89 34 152641 4767 70771002
Sensorimotor disorder 16.82 9.89 14 152661 802 70774967
Wheezing 16.81 9.89 126 152549 94044 70681725
Blood osmolarity decreased 16.79 9.89 17 152658 1254 70774515
Loose associations 16.69 9.89 6 152669 59 70775710
Staphylococcal infection 16.61 9.89 59 152616 53345 70722424
Drug screen positive 16.61 9.89 38 152637 5802 70769967
Somatic delusion 16.52 9.89 13 152662 687 70775082
Skin ulcer 16.48 9.89 51 152624 48094 70727675
Premature delivery 16.47 9.89 13 152662 21291 70754478
Drug dispensed to wrong patient 16.44 9.89 12 152663 566 70775203
Cellulitis 16.44 9.89 135 152540 98793 70676976
Haemophagocytic lymphohistiocytosis 16.43 9.89 11 152664 19601 70756168
Facial nerve disorder 16.36 9.89 13 152662 697 70775072
Somatic symptom disorder 16.34 9.89 21 152654 2009 70773760
Respiratory acidosis 16.30 9.89 54 152621 10227 70765542
Skin exfoliation 16.30 9.89 52 152623 48574 70727195
Product prescribing issue 16.26 9.89 26 152649 3038 70772731
Purple glove syndrome 16.24 9.89 9 152666 261 70775508
Rash pruritic 16.19 9.89 75 152600 62916 70712853
Therapy non-responder 16.19 9.89 98 152577 76817 70698952
Homicide 16.10 9.89 16 152659 1154 70774615
Acne 16.09 9.89 18 152657 24971 70750798
Tricuspid valve sclerosis 16.05 9.89 5 152670 30 70775739
Status epilepticus 16.05 9.89 99 152576 24427 70751342
Blood pressure systolic abnormal 16.04 9.89 4 152671 12905 70762864
Tachypnoea 15.94 9.89 111 152564 28527 70747242
Swollen tongue 15.83 9.89 135 152540 36911 70738858
Drop attacks 15.82 9.89 15 152660 1021 70774748
Hypertension 15.79 9.89 501 152174 295532 70480237
Dyspraxia 15.76 9.89 9 152666 277 70775492
Suspiciousness 15.73 9.89 12 152663 606 70775163
Dissociative disorder 15.69 9.89 11 152664 487 70775282
Neck pain 15.62 9.89 82 152593 66575 70709194
Neutrophil count increased 15.59 9.89 105 152570 26690 70749079
Sinus congestion 15.58 9.89 9 152666 17364 70758405
Stoma site erythema 15.55 9.89 17 152658 1371 70774398
Renal failure 15.52 9.89 300 152375 188770 70586999
Resuscitation 15.49 9.89 22 152653 2315 70773454
Renal disorder 15.46 9.89 37 152638 37972 70737797
Gout 15.45 9.89 16 152659 22990 70752779
Blood pressure diastolic abnormal 15.44 9.89 7 152668 15497 70760272
Tachycardia paroxysmal 15.43 9.89 10 152665 388 70775381
Cerebral mass effect 15.43 9.89 19 152656 1741 70774028
Vertigo 15.32 9.89 204 152471 62439 70713330
Antidepressant drug level increased 15.32 9.89 10 152665 393 70775376
Anorgasmia 15.23 9.89 15 152660 1070 70774699
Haemoglobin decreased 15.22 9.89 331 152344 204828 70570941
Self esteem decreased 15.19 9.89 14 152661 919 70774850
Bacterial infection 15.05 9.89 21 152654 26471 70749298
Aspergillus infection 14.99 9.89 10 152665 17858 70757911
Circadian rhythm sleep disorder 14.98 9.89 12 152663 651 70775118
Rash maculo-papular 14.96 9.89 57 152618 50488 70725281
Behaviour disorder 14.93 9.89 35 152640 5429 70770340
Lung disorder 14.90 9.89 88 152587 69396 70706373
Prostatism 14.79 9.89 6 152669 84 70775685
Epstein-Barr virus infection 14.72 9.89 5 152670 13193 70762576
Neoplasm progression 14.72 9.89 49 152626 45179 70730590
Hypothermia 14.67 9.89 85 152590 20509 70755260
Flushing 14.64 9.89 110 152565 82062 70693707
Lower limb fracture 14.60 9.89 9 152666 16763 70759006
Giant cell arteritis 14.46 9.89 22 152653 2463 70773306
Diverticulitis 14.43 9.89 44 152631 41690 70734079
Liver injury 14.38 9.89 43 152632 40992 70734777
Pulmonary oedema 14.36 9.89 253 152422 82025 70693744
Drug abuser 14.35 9.89 36 152639 5828 70769941
Hepatic steatosis 14.33 9.89 123 152552 33690 70742079
Liver disorder 14.28 9.89 76 152599 61492 70714277
Pulmonary fibrosis 14.28 9.89 33 152642 34277 70741492
Fear 14.25 9.89 85 152590 20726 70755043
Disseminated intravascular coagulation 14.23 9.89 32 152643 33566 70742203
Violence-related symptom 14.23 9.89 12 152663 700 70775069
Wrong technique in product usage process 14.21 9.89 88 152587 68610 70707159
Blood osmolarity increased 14.15 9.89 11 152664 571 70775198
Sinus disorder 14.12 9.89 12 152663 18947 70756822
Cachexia 13.96 9.89 50 152625 9850 70765919
Cardiac failure 13.94 9.89 221 152454 143320 70632449
Creatinine renal clearance decreased 13.94 9.89 10 152665 17190 70758579
Impaired self-care 13.93 9.89 21 152654 2333 70773436
Limited symptom panic attack 13.92 9.89 5 152670 49 70775720
Oral herpes 13.91 9.89 19 152656 24167 70751602
Loss of proprioception 13.90 9.89 12 152663 723 70775046
Ascites 13.73 9.89 87 152588 67460 70708309
Orgasm abnormal 13.72 9.89 7 152668 171 70775598
Hypervolaemia 13.63 9.89 42 152633 39664 70736105
Dysphoria 13.61 9.89 30 152645 4468 70771301
Hypernatraemia 13.58 9.89 59 152616 12702 70763067
Emotional poverty 13.55 9.89 12 152663 748 70775021
Ocular hyperaemia 13.54 9.89 20 152655 24619 70751150
Eyelid myoclonus 13.53 9.89 6 152669 106 70775663
Indifference 13.50 9.89 8 152667 264 70775505
Dyspnoea exertional 13.50 9.89 106 152569 78324 70697445
Generalised anxiety disorder 13.48 9.89 19 152656 1986 70773783
Vasodilatation 13.46 9.89 24 152651 3064 70772705
Panic disorder 13.45 9.89 23 152652 2841 70772928
Mass 13.41 9.89 9 152666 16017 70759752
Arrhythmia 13.38 9.89 182 152493 55961 70719808
Neoplasm malignant 13.37 9.89 26 152649 28748 70747021
Respiratory tract congestion 13.37 9.89 11 152664 17642 70758127
Kidney congestion 13.21 9.89 8 152667 275 70775494
Compulsive shopping 13.18 9.89 12 152663 776 70774993
Poverty of thought content 13.17 9.89 5 152670 58 70775711
Foot deformity 13.17 9.89 15 152660 20640 70755129
Oesophageal haemorrhage 13.13 9.89 17 152658 1638 70774131
Paresis 13.08 9.89 27 152648 3843 70771926
Dysgraphia 13.06 9.89 26 152649 3606 70772163
Anaemia 12.98 9.89 723 151952 402700 70373069
Blood ethanol increased 12.97 9.89 11 152664 647 70775122
Thrombosis 12.94 9.89 102 152573 75303 70700466
COVID-19 pneumonia 12.90 9.89 17 152658 21952 70753817
Post-traumatic stress disorder 12.89 9.89 29 152646 4378 70771391
Dependence 12.88 9.89 20 152655 2280 70773489
Kussmaul respiration 12.86 9.89 9 152666 397 70775372
Second primary malignancy 12.83 9.89 6 152669 13045 70762724
Neutropenia 12.81 9.89 439 152236 256717 70519052
Frequent bowel movements 12.80 9.89 16 152659 21137 70754632
Antiphospholipid antibodies 12.76 9.89 6 152669 122 70775647
Spinal cord injury thoracic 12.76 9.89 6 152669 122 70775647
Ballismus 12.76 9.89 7 152668 199 70775570
Injection site rash 12.71 9.89 10 152665 16400 70759369
Blood creatinine increased 12.64 9.89 224 152451 142777 70632992
Electroencephalogram abnormal 12.58 9.89 32 152643 5226 70770543
Mean cell haemoglobin decreased 12.54 9.89 32 152643 5236 70770533
Hangover 12.53 9.89 18 152657 1915 70773854
Polydipsia psychogenic 12.48 9.89 7 152668 208 70775561
Contusion 12.48 9.89 197 152478 127839 70647930
Visceral congestion 12.47 9.89 12 152663 832 70774937
Pneumocystis jirovecii pneumonia 12.46 9.89 29 152646 30053 70745716
Regressive behaviour 12.46 9.89 6 152669 129 70775640
Dystrophic calcification 12.41 9.89 6 152669 130 70775639
Pulmonary vein occlusion 12.37 9.89 6 152669 131 70775638
Hyperthyroidism 12.37 9.89 15 152660 20076 70755693
Surgery 12.35 9.89 29 152646 29960 70745809
Death 12.35 9.89 1266 151409 508795 70266974
Enthesopathy 12.33 9.89 4 152671 10865 70764904
Drug tolerance decreased 12.31 9.89 3 152672 9830 70765939
Sneezing 12.30 9.89 11 152664 16940 70758829
Light chain disease 12.27 9.89 7 152668 215 70775554
Arachnoid cyst 12.22 9.89 8 152667 316 70775453
Plasma cell myeloma 12.11 9.89 100 152575 73101 70702668
Oxygen saturation decreased 12.08 9.89 177 152498 116252 70659517
Agonal rhythm 12.08 9.89 5 152670 74 70775695
Cytomegalovirus viraemia 12.08 9.89 5 152670 11680 70764089
Sialoadenitis 12.07 9.89 17 152658 1775 70773994
Drug eruption 12.04 9.89 44 152631 39452 70736317
Therapeutic response decreased 12.03 9.89 75 152600 58378 70717391
Immunodeficiency 12.03 9.89 12 152663 17543 70758226
Increased tendency to bruise 12.01 9.89 3 152672 9672 70766097
Injection site urticaria 12.00 9.89 5 152670 11633 70764136
Abdominal pain upper 11.98 9.89 321 152354 193281 70582488
Pulmonary renal syndrome 11.97 9.89 10 152665 576 70775193
Basophil count decreased 11.95 9.89 7 152668 226 70775543
Accidental poisoning 11.94 9.89 16 152659 1594 70774175
Repetitive speech 11.91 9.89 8 152667 330 70775439
Tenderness 11.86 9.89 17 152658 21193 70754576
Hypokalaemia 11.86 9.89 368 152307 130820 70644949
Eosinophilic myocarditis 11.86 9.89 12 152663 885 70774884
Haemolysis 11.85 9.89 5 152670 11546 70764223
Libido decreased 11.85 9.89 30 152645 4886 70770883
Cellulitis orbital 11.84 9.89 11 152664 730 70775039
B-lymphocyte count increased 11.82 9.89 6 152669 145 70775624
Inferior vena caval occlusion 11.75 9.89 4 152671 33 70775736
Pathogen resistance 11.74 9.89 7 152668 13272 70762497
Implant site extravasation 11.72 9.89 11 152664 739 70775030
Bone density decreased 11.71 9.89 5 152670 11469 70764300
Alkalosis hypochloraemic 11.70 9.89 9 152666 460 70775309
Essential tremor 11.69 9.89 15 152660 1432 70774337
Abdominal rigidity 11.67 9.89 21 152654 2700 70773069
Accidental exposure to product 11.65 9.89 27 152648 28024 70747745
Antipsychotic drug level decreased 11.64 9.89 13 152662 1073 70774696
Grip strength decreased 11.60 9.89 10 152665 15675 70760094
Pharyngitis streptococcal 11.60 9.89 3 152672 9445 70766324
Convulsive threshold lowered 11.56 9.89 12 152663 912 70774857
Memory impairment 11.56 9.89 271 152404 92370 70683399
Bacteraemia 11.55 9.89 29 152646 29280 70746489
Rabbit syndrome 11.55 9.89 8 152667 347 70775422
Hepatotoxicity 11.53 9.89 52 152623 43934 70731835
Blood pressure fluctuation 11.49 9.89 77 152598 58935 70716834
C-reactive protein increased 11.47 9.89 168 152507 110349 70665420
Extensor plantar response 11.41 9.89 16 152659 1664 70774105
Perforated ulcer 11.32 9.89 10 152665 621 70775148
Drug withdrawal headache 11.29 9.89 5 152670 88 70775681
Blood cholesterol increased 11.27 9.89 87 152588 64517 70711252
Injection site warmth 11.25 9.89 8 152667 13817 70761952
Bipolar I disorder 11.20 9.89 17 152658 1900 70773869
Bronchial aspiration procedure 11.20 9.89 7 152668 255 70775514
Verbal abuse 11.15 9.89 7 152668 257 70775512
Alcohol abuse 11.11 9.89 30 152645 5077 70770692
Toxicologic test abnormal 11.11 9.89 14 152661 1313 70774456
Radial nerve injury 11.07 9.89 4 152671 40 70775729
Skin infection 11.05 9.89 11 152664 16101 70759668
Personality change 11.01 9.89 43 152632 8827 70766942
Gamma-glutamyltransferase abnormal 10.99 9.89 9 152666 504 70775265
Obstructive airways disorder 10.96 9.89 25 152650 26088 70749681
Tongue movement disturbance 10.93 9.89 8 152667 379 70775390
Spontaneous haemorrhage 10.90 9.89 9 152666 510 70775259
Brain oedema 10.89 9.89 87 152588 23331 70752438
Lymphadenopathy 10.89 9.89 61 152614 48730 70727039
Dry skin 10.88 9.89 73 152602 55858 70719911
Hyperuricaemia 10.85 9.89 5 152670 10961 70764808
Carbon monoxide poisoning 10.84 9.89 7 152668 270 70775499
Coagulopathy 10.84 9.89 36 152639 33213 70742556
Shared psychotic disorder 10.81 9.89 4 152671 43 70775726
Sciatica 10.81 9.89 23 152652 24604 70751165
Labelled drug-disease interaction issue 10.73 9.89 4 152671 44 70775725
Mood disorder due to a general medical condition 10.73 9.89 4 152671 44 70775725
Gastric cancer 10.70 9.89 3 152672 8952 70766817
Foot fracture 10.68 9.89 16 152659 19584 70756185
Hypertriglyceridaemia 10.64 9.89 52 152623 11759 70764010
Bronchopulmonary aspergillosis 10.63 9.89 18 152657 20984 70754785
Jealous delusion 10.61 9.89 7 152668 280 70775489
Coordination abnormal 10.60 9.89 65 152610 16001 70759768
Disorganised speech 10.56 9.89 16 152659 1785 70773984
Cerebral atrophy 10.54 9.89 38 152637 7509 70768260
Ulcer 10.53 9.89 25 152650 25729 70750040
Personality disorder 10.52 9.89 31 152644 5517 70770252
Unemployment 10.42 9.89 4 152671 48 70775721
Injury 10.40 9.89 90 152585 65155 70710614
Gambling 10.37 9.89 7 152668 291 70775478
Eye disorder 10.35 9.89 18 152657 20767 70755002
No adverse event 10.35 9.89 35 152640 32118 70743651
Peripheral T-cell lymphoma unspecified recurrent 10.34 9.89 4 152671 49 70775720
Upper-airway cough syndrome 10.32 9.89 4 152671 9727 70766042
Resting tremor 10.32 9.89 14 152661 1412 70774357
Insulin resistance 10.30 9.89 13 152662 1221 70774548
Nephrotic syndrome 10.30 9.89 5 152670 10635 70765134
Chronic kidney disease 10.29 9.89 83 152592 60974 70714795
Aphasia 10.23 9.89 140 152535 43109 70732660
Autoimmune disorder 10.23 9.89 3 152672 8693 70767076
Peritonitis 10.22 9.89 26 152649 26133 70749636
Abscess 10.19 9.89 18 152657 20636 70755133
Full blood count abnormal 10.16 9.89 38 152637 33840 70741929
Joint effusion 10.13 9.89 11 152664 15466 70760303
Spinal stenosis 10.06 9.89 10 152665 14643 70761126
Breast cancer female 10.04 9.89 5 152670 10481 70765288
Aspergillus test positive 10.03 9.89 10 152665 724 70775045
Hypercalcaemia 10.03 9.89 39 152636 34346 70741423
Hepatocellular injury 10.02 9.89 147 152528 45944 70729825
Partner stress 9.96 9.89 7 152668 311 70775458
Chemical burns of eye 9.96 9.89 5 152670 118 70775651
Post viral fatigue syndrome 9.94 9.89 7 152668 312 70775457
Loss of personal independence in daily activities 9.92 9.89 126 152549 84784 70690985

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neonatal seizure 36.23 30.88 28 595 437 88732

Pharmacologic Action:

SourceCodeDescription
ATC N06AX11 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Other antidepressants
MeSH PA D018663 Adrenergic Agents
MeSH PA D058669 Adrenergic alpha-2 Receptor Antagonists
MeSH PA D000317 Adrenergic alpha-Antagonists
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D000928 Antidepressive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D058830 Serotonin 5-HT2 Receptor Antagonists
MeSH PA D058831 Serotonin 5-HT3 Receptor Antagonists
MeSH PA D018490 Serotonin Agents
MeSH PA D012702 Serotonin Antagonists
MeSH PA D014149 Tranquilizing Agents
CHEBI has role CHEBI:35474 anti-anxiety agents
CHEBI has role CHEBI:37890 alpha-adrenergic receptor blockaders
CHEBI has role CHEBI:37955 H1 receptor antagonists
CHEBI has role CHEBI:37956 antihistamines
CHEBI has role CHEBI:48279 serotonin antagonists
CHEBI has role CHEBI:146270 oneirogens

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Major depressive disorder indication 370143000
Excessive vomiting in pregnancy off-label use 14094001
Posttraumatic stress disorder off-label use 47505003 DOID:2055
Suicidal thoughts contraindication 6471006
Weight gain finding contraindication 8943002
Hypercholesterolemia contraindication 13644009
Myocardial infarction contraindication 22298006 DOID:5844
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Dehydration contraindication 34095006
Low blood pressure contraindication 45007003
Cerebrovascular disease contraindication 62914000 DOID:6713
Hyponatremia contraindication 89627008
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Bipolar affective disorder, current episode manic contraindication 191618007
Angina pectoris contraindication 194828000
Impaired renal function disorder contraindication 197663003
Cerebrovascular accident contraindication 230690007
Disease of liver contraindication 235856003 DOID:409
Akathisia contraindication 285145004
Hypertriglyceridemia contraindication 302870006
Neutropenic disorder contraindication 303011007 DOID:1227
Serotonin syndrome contraindication 371089000
Obesity contraindication 414916001 DOID:9970
Acute Thromboembolic Stroke contraindication




🐢 Veterinary Drug Use

SpeciesUseRelation
Cats Management of weight loss in cats Indication

🐢 Veterinary products

ProductApplicantIngredients
Mirataz Dechra, Ltd. 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.67 Basic
pKa2 2.91 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST Ki 7.41 CHEMBL CHEMBL
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 7.16 CHEMBL CHEMBL
Alpha-2A adrenergic receptor GPCR ANTAGONIST Ki 7.70 CHEMBL
Sodium-dependent noradrenaline transporter Transporter Ki 5.34 PDSP
5-hydroxytryptamine receptor 1A GPCR Kd 5.30 CHEMBL
5-hydroxytryptamine receptor 7 GPCR Ki 6.58 CHEMBL
Alpha-1A adrenergic receptor GPCR IC50 5.50 CHEMBL
Alpha-2B adrenergic receptor GPCR ANTAGONIST IC50 6.65 CHEMBL
D(3) dopamine receptor GPCR Ki 5.24 CHEMBL
Histamine H1 receptor GPCR Ki 8.80 WOMBAT-PK
Muscarinic acetylcholine receptor M1 GPCR WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR WOMBAT-PK
Alpha-2C adrenergic receptor GPCR ANTAGONIST Ki 7.74 CHEMBL
5-hydroxytryptamine receptor 3A Ion channel Ki 5.54 CHEMBL
D(1A) dopamine receptor GPCR Ki 5.38 PDSP
D(2) dopamine receptor GPCR Ki 5.26 PDSP
D(2) dopamine receptor GPCR Ki 5.84 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 8.70 CHEMBL
Transporter Transporter Ki 5.79 CHEMBL
D(1A) dopamine receptor GPCR Ki 5.38 CHEMBL
5-hydroxytryptamine receptor 2C GPCR Ki 8.26 CHEMBL
Adrenergic receptor alpha-1 GPCR Ki 6.22 CHEMBL

External reference:

IDSource
4020978 VUID
N0000148449 NUI
D00563 KEGG_DRUG
4020978 VANDF
C0049506 UMLSCUI
CHEBI:6950 CHEBI
CHEMBL654 ChEMBL_ID
DB00370 DRUGBANK_ID
D000078785 MESH_DESCRIPTOR_UI
4205 PUBCHEM_CID
7241 IUPHAR_LIGAND_ID
6481 INN_ID
A051Q2099Q UNII
15996 RXNORM
46110 MMSL
5120 MMSL
d04025 MMSL
006054 NDDF
108430001 SNOMEDCT_US
386847004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
REMERON HUMAN PRESCRIPTION DRUG LABEL 1 0052-0105 TABLET, FILM COATED 15 mg ORAL NDA 31 sections
REMERONSOLTAB HUMAN PRESCRIPTION DRUG LABEL 1 0052-0106 TABLET, ORALLY DISINTEGRATING 15 mg ORAL NDA 31 sections
REMERON HUMAN PRESCRIPTION DRUG LABEL 1 0052-0107 TABLET, FILM COATED 30 mg ORAL NDA 31 sections
REMERONSOLTAB HUMAN PRESCRIPTION DRUG LABEL 1 0052-0108 TABLET, ORALLY DISINTEGRATING 30 mg ORAL NDA 31 sections
REMERON HUMAN PRESCRIPTION DRUG LABEL 1 0052-0109 TABLET, FILM COATED 45 mg ORAL NDA 31 sections
REMERONSOLTAB HUMAN PRESCRIPTION DRUG LABEL 1 0052-0110 TABLET, ORALLY DISINTEGRATING 45 mg ORAL NDA 31 sections
REMERON HUMAN PRESCRIPTION DRUG LABEL 1 0052-4364 TABLET, FILM COATED 15 mg ORAL NDA 31 sections
REMERON HUMAN PRESCRIPTION DRUG LABEL 1 0052-4365 TABLET, FILM COATED 30 mg ORAL NDA 31 sections
Mirtazapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-3515 TABLET, FILM COATED 15 mg ORAL ANDA 29 sections
Mirtazapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-3515 TABLET, FILM COATED 15 mg ORAL ANDA 29 sections
Mirtazapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-3530 TABLET, FILM COATED 30 mg ORAL ANDA 29 sections
Mirtazapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-3530 TABLET, FILM COATED 30 mg ORAL ANDA 29 sections
Mirtazapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-3545 TABLET, FILM COATED 45 mg ORAL ANDA 29 sections
Mirtazapine HUMAN PRESCRIPTION DRUG LABEL 1 0378-3545 TABLET, FILM COATED 45 mg ORAL ANDA 29 sections
Mirtazapine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8078 TABLET 7.50 mg ORAL ANDA 25 sections
Mirtazapine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8268 TABLET, FILM COATED 15 mg ORAL ANDA 25 sections
Mirtazapine HUMAN PRESCRIPTION DRUG LABEL 1 0615-8269 TABLET, FILM COATED 30 mg ORAL ANDA 25 sections
Mirtazapine HUMAN PRESCRIPTION DRUG LABEL 1 0904-6519 TABLET, FILM COATED 15 mg ORAL ANDA 25 sections
Mirtazapine HUMAN PRESCRIPTION DRUG LABEL 1 0904-6519 TABLET, FILM COATED 15 mg ORAL ANDA 25 sections
Mirtazapine Human Prescription Drug Label 1 13107-001 TABLET, FILM COATED 7.50 mg ORAL ANDA 28 sections
Mirtazapine Human Prescription Drug Label 1 13107-001 TABLET, FILM COATED 7.50 mg ORAL ANDA 28 sections
Mirtazapine Human Prescription Drug Label 1 13107-003 TABLET, FILM COATED 30 mg ORAL ANDA 28 sections
Mirtazapine Human Prescription Drug Label 1 13107-003 TABLET, FILM COATED 30 mg ORAL ANDA 28 sections
Mirtazapine Human Prescription Drug Label 1 13107-031 TABLET, FILM COATED 15 mg ORAL ANDA 28 sections
Mirtazapine Human Prescription Drug Label 1 13107-031 TABLET, FILM COATED 15 mg ORAL ANDA 28 sections
Mirtazapine Human Prescription Drug Label 1 13107-032 TABLET, FILM COATED 45 mg ORAL ANDA 28 sections
Mirtazapine Human Prescription Drug Label 1 13107-032 TABLET, FILM COATED 45 mg ORAL ANDA 28 sections
MIRTAZAPINE HUMAN PRESCRIPTION DRUG LABEL 1 16590-153 TABLET, FILM COATED 15 mg ORAL ANDA 26 sections
MIRTAZAPINE HUMAN PRESCRIPTION DRUG LABEL 1 16590-154 TABLET, FILM COATED 30 mg ORAL ANDA 26 sections
MIRTAZAPINE HUMAN PRESCRIPTION DRUG LABEL 1 16590-155 TABLET, FILM COATED 45 mg ORAL ANDA 26 sections