Stem definition | Drug id | CAS RN |
---|---|---|
psychoactive | 1816 | 85650-52-8 |
Dose | Unit | Route |
---|---|---|
30 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.50 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 2 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 2.83 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 50 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 4.20 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 8 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.15 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 15 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
June 14, 1996 | FDA | ORGANON USA INC |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Intentional overdose | 677.94 | 10.03 | 722 | 99309 | 61782 | 50443311 |
Serotonin syndrome | 528.86 | 10.03 | 418 | 99613 | 24295 | 50480798 |
Intentional self-injury | 522.90 | 10.03 | 404 | 99627 | 22708 | 50482385 |
Suicide attempt | 507.53 | 10.03 | 567 | 99464 | 51165 | 50453928 |
Toxicity to various agents | 479.59 | 10.03 | 1197 | 98834 | 211302 | 50293791 |
Drug abuse | 453.51 | 10.03 | 575 | 99456 | 59271 | 50445822 |
Sopor | 414.09 | 10.03 | 331 | 99700 | 19548 | 50485545 |
Completed suicide | 380.78 | 10.03 | 819 | 99212 | 131070 | 50374023 |
Suicidal ideation | 365.12 | 10.03 | 497 | 99534 | 54888 | 50450205 |
Drug interaction | 351.02 | 10.03 | 1026 | 99005 | 198595 | 50306498 |
Electrocardiogram QT prolonged | 347.18 | 10.03 | 469 | 99562 | 51417 | 50453676 |
Overdose | 294.23 | 10.03 | 625 | 99406 | 99102 | 50405991 |
Hyponatraemia | 291.16 | 10.03 | 609 | 99422 | 95530 | 50409563 |
Somnolence | 267.79 | 10.03 | 792 | 99239 | 154193 | 50350900 |
Agitation | 251.09 | 10.03 | 409 | 99622 | 52975 | 50452118 |
Joint swelling | 213.88 | 10.03 | 109 | 99922 | 245177 | 50259916 |
Systemic lupus erythematosus | 213.81 | 10.03 | 17 | 100014 | 140605 | 50364488 |
Drug ineffective | 208.03 | 10.03 | 876 | 99155 | 818457 | 49686636 |
Pemphigus | 206.13 | 10.03 | 7 | 100024 | 120159 | 50384934 |
Rheumatoid arthritis | 201.98 | 10.03 | 74 | 99957 | 202476 | 50302617 |
Restlessness | 190.73 | 10.03 | 242 | 99789 | 24931 | 50480162 |
Treatment failure | 190.10 | 10.03 | 24 | 100007 | 137613 | 50367480 |
Arthropathy | 186.26 | 10.03 | 42 | 99989 | 157864 | 50347229 |
Depressed level of consciousness | 185.86 | 10.03 | 353 | 99678 | 51600 | 50453493 |
Neuroleptic malignant syndrome | 185.54 | 10.03 | 163 | 99868 | 10967 | 50494126 |
Tremor | 183.11 | 10.03 | 571 | 99460 | 114332 | 50390761 |
Infusion related reaction | 179.35 | 10.03 | 56 | 99975 | 169501 | 50335592 |
Disorientation | 179.35 | 10.03 | 281 | 99750 | 35203 | 50469890 |
Muscle rigidity | 178.14 | 10.03 | 151 | 99880 | 9678 | 50495415 |
Inappropriate antidiuretic hormone secretion | 175.43 | 10.03 | 170 | 99861 | 12973 | 50492120 |
Rash | 173.47 | 10.03 | 380 | 99651 | 437091 | 50068002 |
Confusional state | 171.57 | 10.03 | 775 | 99256 | 185153 | 50319940 |
Tachycardia | 171.33 | 10.03 | 509 | 99522 | 99254 | 50405839 |
Swelling | 168.09 | 10.03 | 94 | 99937 | 200778 | 50304315 |
Glossodynia | 164.93 | 10.03 | 18 | 100013 | 115551 | 50389542 |
Alopecia | 160.29 | 10.03 | 149 | 99882 | 244898 | 50260195 |
Contraindicated product administered | 159.68 | 10.03 | 48 | 99983 | 148910 | 50356183 |
Coma | 157.90 | 10.03 | 348 | 99683 | 56531 | 50448562 |
Dissociation | 157.17 | 10.03 | 81 | 99950 | 2210 | 50502883 |
Fall | 151.60 | 10.03 | 1156 | 98875 | 333776 | 50171317 |
Sinusitis | 149.76 | 10.03 | 75 | 99956 | 170483 | 50334610 |
Disturbance in attention | 148.02 | 10.03 | 240 | 99791 | 30946 | 50474147 |
Depersonalisation/derealisation disorder | 142.82 | 10.03 | 62 | 99969 | 1136 | 50503957 |
Synovitis | 136.26 | 10.03 | 38 | 99993 | 123827 | 50381266 |
Abdominal discomfort | 135.45 | 10.03 | 155 | 99876 | 231486 | 50273607 |
Pain | 130.79 | 10.03 | 645 | 99386 | 578258 | 49926835 |
Mydriasis | 128.02 | 10.03 | 130 | 99901 | 10497 | 50494596 |
Akathisia | 126.24 | 10.03 | 115 | 99916 | 8114 | 50496979 |
Dyskinesia | 124.93 | 10.03 | 209 | 99822 | 27652 | 50477441 |
Gastric pH decreased | 122.64 | 10.03 | 47 | 99984 | 615 | 50504478 |
Nasopharyngitis | 119.51 | 10.03 | 123 | 99908 | 192804 | 50312289 |
Drug intolerance | 119.22 | 10.03 | 155 | 99876 | 218949 | 50286144 |
Therapeutic product effect decreased | 117.65 | 10.03 | 61 | 99970 | 135989 | 50369104 |
Anxiety | 116.55 | 10.03 | 673 | 99358 | 176933 | 50328160 |
Nightmare | 116.11 | 10.03 | 151 | 99880 | 15935 | 50489158 |
Restless legs syndrome | 115.96 | 10.03 | 150 | 99881 | 15747 | 50489346 |
Derealisation | 114.56 | 10.03 | 51 | 99980 | 995 | 50504098 |
Feeling of despair | 106.65 | 10.03 | 60 | 99971 | 1958 | 50503135 |
Hypersensitivity | 104.42 | 10.03 | 165 | 99866 | 214996 | 50290097 |
Peripheral swelling | 103.70 | 10.03 | 154 | 99877 | 205782 | 50299311 |
Depressed mood | 102.23 | 10.03 | 215 | 99816 | 33808 | 50471285 |
Drug hypersensitivity | 101.77 | 10.03 | 215 | 99816 | 250795 | 50254298 |
Dysarthria | 101.69 | 10.03 | 227 | 99804 | 37176 | 50467917 |
Arthralgia | 101.67 | 10.03 | 484 | 99547 | 438218 | 50066875 |
Urinary retention | 101.19 | 10.03 | 184 | 99847 | 26006 | 50479087 |
Cogwheel rigidity | 99.83 | 10.03 | 55 | 99976 | 1722 | 50503371 |
Aggression | 98.15 | 10.03 | 161 | 99870 | 20955 | 50484138 |
Hallucination | 96.70 | 10.03 | 255 | 99776 | 46402 | 50458691 |
Drug withdrawal syndrome | 95.38 | 10.03 | 175 | 99856 | 24906 | 50480187 |
Pericarditis | 94.61 | 10.03 | 20 | 100011 | 78669 | 50426424 |
Delirium | 94.14 | 10.03 | 223 | 99808 | 37969 | 50467124 |
Mania | 87.55 | 10.03 | 108 | 99923 | 10808 | 50494285 |
Seizure | 87.51 | 10.03 | 462 | 99569 | 117412 | 50387681 |
Helicobacter infection | 84.83 | 10.03 | 3 | 100028 | 49699 | 50455394 |
Hyperhidrosis | 84.00 | 10.03 | 375 | 99656 | 89051 | 50416042 |
Injection site pain | 83.09 | 10.03 | 59 | 99972 | 110965 | 50394128 |
Withdrawal syndrome | 82.95 | 10.03 | 135 | 99896 | 17455 | 50487638 |
General physical health deterioration | 82.72 | 10.03 | 523 | 99508 | 141911 | 50363182 |
Dystonia | 81.51 | 10.03 | 109 | 99922 | 11817 | 50493276 |
Psychotic disorder | 81.44 | 10.03 | 151 | 99880 | 21661 | 50483432 |
Discomfort | 80.57 | 10.03 | 58 | 99973 | 108322 | 50396771 |
Hallucination, visual | 80.56 | 10.03 | 129 | 99902 | 16453 | 50488640 |
Urticaria | 79.73 | 10.03 | 83 | 99948 | 129478 | 50375615 |
Rheumatoid factor negative | 77.95 | 10.03 | 33 | 99998 | 567 | 50504526 |
Product use issue | 77.95 | 10.03 | 109 | 99922 | 149366 | 50355727 |
Duodenal ulcer perforation | 76.99 | 10.03 | 3 | 100028 | 45608 | 50459485 |
Tardive dyskinesia | 73.38 | 10.03 | 81 | 99950 | 7198 | 50497895 |
H1N1 influenza | 72.47 | 10.03 | 43 | 99988 | 1554 | 50503539 |
Schizophrenia | 72.31 | 10.03 | 81 | 99950 | 7316 | 50497777 |
Impaired healing | 72.04 | 10.03 | 24 | 100007 | 69762 | 50435331 |
Poisoning | 70.67 | 10.03 | 104 | 99927 | 12325 | 50492768 |
Parkinsonism | 70.10 | 10.03 | 87 | 99944 | 8760 | 50496333 |
Drooling | 69.69 | 10.03 | 56 | 99975 | 3328 | 50501765 |
Myoclonus | 65.46 | 10.03 | 109 | 99922 | 14361 | 50490732 |
Folliculitis | 64.81 | 10.03 | 3 | 100028 | 39222 | 50465871 |
Depression | 64.28 | 10.03 | 552 | 99479 | 164871 | 50340222 |
Pleurothotonus | 61.58 | 10.03 | 36 | 99995 | 1265 | 50503828 |
Intestinal pseudo-obstruction | 61.56 | 10.03 | 30 | 100001 | 724 | 50504369 |
Loss of consciousness | 61.06 | 10.03 | 384 | 99647 | 103969 | 50401124 |
Maternal exposure during pregnancy | 60.47 | 10.03 | 142 | 99889 | 159636 | 50345457 |
Depressive symptom | 59.71 | 10.03 | 50 | 99981 | 3150 | 50501943 |
Mood swings | 57.75 | 10.03 | 109 | 99922 | 15845 | 50489248 |
Injection site erythema | 57.14 | 10.03 | 39 | 99992 | 74897 | 50430196 |
Hallucination, auditory | 57.04 | 10.03 | 87 | 99944 | 10641 | 50494452 |
Parosmia | 56.61 | 10.03 | 56 | 99975 | 4380 | 50500713 |
Psoriatic arthropathy | 56.43 | 10.03 | 12 | 100019 | 47020 | 50458073 |
Infection | 56.10 | 10.03 | 166 | 99865 | 172788 | 50332305 |
Incontinence | 55.97 | 10.03 | 83 | 99948 | 9902 | 50495191 |
Hyperkinesia | 55.41 | 10.03 | 35 | 99996 | 1417 | 50503676 |
Feeling jittery | 54.46 | 10.03 | 87 | 99944 | 11073 | 50494020 |
Wound | 54.28 | 10.03 | 78 | 99953 | 105716 | 50399377 |
Sedation | 54.21 | 10.03 | 158 | 99873 | 30452 | 50474641 |
Hypertonia | 54.16 | 10.03 | 52 | 99979 | 3921 | 50501172 |
Pruritus | 52.83 | 10.03 | 336 | 99695 | 283232 | 50221861 |
Lower respiratory tract infection | 52.06 | 10.03 | 67 | 99964 | 95134 | 50409959 |
Injection site pruritus | 51.26 | 10.03 | 9 | 100022 | 40402 | 50464691 |
Pallor | 50.31 | 10.03 | 129 | 99902 | 23070 | 50482023 |
Accidental overdose | 50.25 | 10.03 | 116 | 99915 | 19417 | 50485676 |
Drug dependence | 49.36 | 10.03 | 116 | 99915 | 19643 | 50485450 |
Psychomotor retardation | 49.00 | 10.03 | 46 | 99985 | 3372 | 50501721 |
Asphyxia | 48.94 | 10.03 | 57 | 99974 | 5370 | 50499723 |
Fatigue | 48.52 | 10.03 | 1049 | 98982 | 706552 | 49798541 |
Speech disorder | 47.88 | 10.03 | 167 | 99864 | 35381 | 50469712 |
Knee arthroplasty | 47.67 | 10.03 | 7 | 100024 | 35839 | 50469254 |
Muscle injury | 47.65 | 10.03 | 8 | 100023 | 37103 | 50467990 |
Arthritis | 47.45 | 10.03 | 61 | 99970 | 86660 | 50418433 |
Hepatic enzyme increased | 47.39 | 10.03 | 128 | 99903 | 137252 | 50367841 |
Extrapyramidal disorder | 47.13 | 10.03 | 84 | 99947 | 11686 | 50493407 |
Abnormal dreams | 47.00 | 10.03 | 74 | 99957 | 9303 | 50495790 |
Headache | 46.94 | 10.03 | 712 | 99319 | 505823 | 49999270 |
Cardiac arrest | 46.57 | 10.03 | 304 | 99727 | 83347 | 50421746 |
Feeling of body temperature change | 46.47 | 10.03 | 50 | 99981 | 4317 | 50500776 |
Irritable bowel syndrome | 46.04 | 10.03 | 22 | 100009 | 51419 | 50453674 |
Blister | 45.80 | 10.03 | 61 | 99970 | 85357 | 50419736 |
Cough | 45.36 | 10.03 | 285 | 99746 | 240979 | 50264114 |
Gestational diabetes | 44.67 | 10.03 | 64 | 99967 | 7401 | 50497692 |
Hallucinations, mixed | 43.70 | 10.03 | 47 | 99984 | 4056 | 50501037 |
Gastrointestinal disorder | 43.37 | 10.03 | 75 | 99956 | 94381 | 50410712 |
C-reactive protein abnormal | 43.26 | 10.03 | 3 | 100028 | 27806 | 50477287 |
Muscle disorder | 43.15 | 10.03 | 48 | 99983 | 4302 | 50500791 |
Rhabdomyolysis | 43.10 | 10.03 | 172 | 99859 | 38855 | 50466238 |
Delusion | 43.05 | 10.03 | 76 | 99955 | 10493 | 50494600 |
Polydipsia | 42.80 | 10.03 | 41 | 99990 | 3083 | 50502010 |
Pain in extremity | 42.68 | 10.03 | 340 | 99691 | 272525 | 50232568 |
Nasal congestion | 42.58 | 10.03 | 24 | 100007 | 51096 | 50453997 |
Device expulsion | 42.36 | 10.03 | 4 | 100027 | 28818 | 50476275 |
Intentional product use issue | 42.19 | 10.03 | 54 | 99977 | 76864 | 50428229 |
Altered state of consciousness | 41.62 | 10.03 | 116 | 99915 | 21794 | 50483299 |
Off label use | 41.52 | 10.03 | 674 | 99357 | 473752 | 50031341 |
Acute motor-sensory axonal neuropathy | 41.31 | 10.03 | 17 | 100014 | 271 | 50504822 |
Menstrual disorder | 41.26 | 10.03 | 47 | 99984 | 4323 | 50500770 |
Chorea | 40.68 | 10.03 | 28 | 100003 | 1312 | 50503781 |
Hypertonia neonatal | 40.51 | 10.03 | 16 | 100015 | 228 | 50504865 |
Poisoning deliberate | 40.43 | 10.03 | 63 | 99968 | 7849 | 50497244 |
Panic attack | 40.35 | 10.03 | 106 | 99925 | 19236 | 50485857 |
Abnormal behaviour | 40.26 | 10.03 | 107 | 99924 | 19551 | 50485542 |
Product dose omission issue | 40.02 | 10.03 | 207 | 99824 | 183631 | 50321462 |
Sleep paralysis | 39.96 | 10.03 | 20 | 100011 | 512 | 50504581 |
Major depression | 39.71 | 10.03 | 58 | 99973 | 6826 | 50498267 |
Therapeutic product ineffective | 39.65 | 10.03 | 27 | 100004 | 1243 | 50503850 |
Psychomotor hyperactivity | 39.34 | 10.03 | 68 | 99963 | 9233 | 50495860 |
Decreased appetite | 39.28 | 10.03 | 586 | 99445 | 200337 | 50304756 |
Product administration error | 39.12 | 10.03 | 106 | 99925 | 19593 | 50485500 |
Impulsive behaviour | 38.55 | 10.03 | 28 | 100003 | 1430 | 50503663 |
Anger | 38.04 | 10.03 | 75 | 99956 | 11258 | 50493835 |
Ventricular fibrillation | 38.04 | 10.03 | 72 | 99959 | 10487 | 50494606 |
Persecutory delusion | 37.87 | 10.03 | 34 | 99997 | 2353 | 50502740 |
Sleep disorder | 37.44 | 10.03 | 217 | 99814 | 57066 | 50448027 |
Unresponsive to stimuli | 37.15 | 10.03 | 139 | 99892 | 30470 | 50474623 |
Dysphagia | 36.25 | 10.03 | 270 | 99761 | 77248 | 50427845 |
Hypoaesthesia oral | 36.01 | 10.03 | 71 | 99960 | 10657 | 50494436 |
Back pain | 35.39 | 10.03 | 272 | 99759 | 219758 | 50285335 |
Galactorrhoea | 35.08 | 10.03 | 40 | 99991 | 3683 | 50501410 |
Panic reaction | 34.74 | 10.03 | 39 | 99992 | 3530 | 50501563 |
Cyanosis | 34.56 | 10.03 | 86 | 99945 | 15098 | 50489995 |
Stomatitis | 34.51 | 10.03 | 95 | 99936 | 101249 | 50403844 |
Aphasia | 34.25 | 10.03 | 129 | 99902 | 28365 | 50476728 |
Hip arthroplasty | 34.07 | 10.03 | 9 | 100022 | 30420 | 50474673 |
Injection site bruising | 34.03 | 10.03 | 15 | 100016 | 36753 | 50468340 |
Erythema | 33.49 | 10.03 | 162 | 99869 | 146252 | 50358841 |
Aspiration | 33.16 | 10.03 | 63 | 99968 | 9201 | 50495892 |
Intentional product misuse | 33.16 | 10.03 | 181 | 99850 | 46553 | 50458540 |
Hypophagia | 32.89 | 10.03 | 125 | 99906 | 27603 | 50477490 |
Opisthotonus | 32.73 | 10.03 | 15 | 100016 | 314 | 50504779 |
Epilepsy | 32.30 | 10.03 | 105 | 99926 | 21462 | 50483631 |
Product prescribing error | 32.25 | 10.03 | 103 | 99928 | 20858 | 50484235 |
Abulia | 31.92 | 10.03 | 16 | 100015 | 411 | 50504682 |
Fracture | 31.85 | 10.03 | 89 | 99942 | 16744 | 50488349 |
Paranoia | 31.78 | 10.03 | 66 | 99965 | 10282 | 50494811 |
Tonic clonic movements | 31.00 | 10.03 | 23 | 100008 | 1214 | 50503879 |
Drug withdrawal syndrome neonatal | 30.75 | 10.03 | 27 | 100004 | 1814 | 50503279 |
Ballismus | 30.69 | 10.03 | 10 | 100021 | 78 | 50505015 |
Bradypnoea | 30.63 | 10.03 | 34 | 99997 | 3040 | 50502053 |
Miosis | 30.52 | 10.03 | 49 | 99982 | 6261 | 50498832 |
Syncope | 30.20 | 10.03 | 324 | 99707 | 102678 | 50402415 |
Injection site swelling | 30.19 | 10.03 | 23 | 100008 | 41750 | 50463343 |
Coma scale abnormal | 30.17 | 10.03 | 42 | 99989 | 4729 | 50500364 |
Histrionic personality disorder | 30.08 | 10.03 | 9 | 100022 | 51 | 50505042 |
Self-injurious ideation | 30.05 | 10.03 | 29 | 100002 | 2200 | 50502893 |
Herpes zoster | 30.01 | 10.03 | 59 | 99972 | 70727 | 50434366 |
Psoriasis | 29.69 | 10.03 | 57 | 99974 | 68943 | 50436150 |
Irritability | 29.58 | 10.03 | 123 | 99908 | 28303 | 50476790 |
Therapeutic product effect incomplete | 29.53 | 10.03 | 88 | 99943 | 91427 | 50413666 |
Hypokalaemia | 29.24 | 10.03 | 284 | 99747 | 87708 | 50417385 |
Generalised tonic-clonic seizure | 29.08 | 10.03 | 116 | 99915 | 26194 | 50478899 |
Respiratory arrest | 29.02 | 10.03 | 127 | 99904 | 29882 | 50475211 |
Cardio-respiratory arrest | 28.86 | 10.03 | 194 | 99837 | 53698 | 50451395 |
Circulatory collapse | 28.72 | 10.03 | 96 | 99935 | 19904 | 50485189 |
Autonomic nervous system imbalance | 28.40 | 10.03 | 29 | 100002 | 2356 | 50502737 |
Chemical burn of oral cavity | 28.34 | 10.03 | 9 | 100022 | 64 | 50505029 |
Immune reconstitution inflammatory syndrome | 28.29 | 10.03 | 44 | 99987 | 5472 | 50499621 |
Sensory loss | 28.17 | 10.03 | 53 | 99978 | 7685 | 50497408 |
Paralysis | 27.48 | 10.03 | 56 | 99975 | 8608 | 50496485 |
Language disorder | 27.45 | 10.03 | 25 | 100006 | 1763 | 50503330 |
Cognitive disorder | 27.44 | 10.03 | 165 | 99866 | 43958 | 50461135 |
Rhonchi | 27.38 | 10.03 | 28 | 100003 | 2279 | 50502814 |
Blood prolactin increased | 27.03 | 10.03 | 32 | 99999 | 3067 | 50502026 |
Crush syndrome | 26.95 | 10.03 | 10 | 100021 | 119 | 50504974 |
Urinary hesitation | 26.61 | 10.03 | 26 | 100005 | 2003 | 50503090 |
Acute psychosis | 26.45 | 10.03 | 27 | 100004 | 2193 | 50502900 |
Ill-defined disorder | 26.38 | 10.03 | 42 | 99989 | 54612 | 50450481 |
Helplessness | 26.23 | 10.03 | 12 | 100019 | 250 | 50504843 |
Swollen tongue | 25.32 | 10.03 | 118 | 99913 | 28512 | 50476581 |
Agranulocytosis | 24.94 | 10.03 | 96 | 99935 | 21325 | 50483768 |
Norepinephrine increased | 24.71 | 10.03 | 8 | 100023 | 61 | 50505032 |
Asthma | 24.64 | 10.03 | 92 | 99939 | 89245 | 50415848 |
Social avoidant behaviour | 24.59 | 10.03 | 29 | 100002 | 2768 | 50502325 |
Injection site reaction | 24.57 | 10.03 | 38 | 99993 | 49994 | 50455099 |
Neonatal hypoxia | 24.55 | 10.03 | 14 | 100017 | 469 | 50504624 |
Visceral congestion | 24.24 | 10.03 | 12 | 100019 | 300 | 50504793 |
Agitation neonatal | 24.02 | 10.03 | 14 | 100017 | 489 | 50504604 |
Phagophobia | 23.96 | 10.03 | 7 | 100024 | 36 | 50505057 |
Sudden death | 23.79 | 10.03 | 54 | 99977 | 8937 | 50496156 |
Haematemesis | 23.59 | 10.03 | 113 | 99918 | 27612 | 50477481 |
Pyelonephritis | 23.37 | 10.03 | 74 | 99957 | 14915 | 50490178 |
Progressive multifocal leukoencephalopathy | 23.10 | 10.03 | 62 | 99969 | 11395 | 50493698 |
Facial nerve disorder | 22.96 | 10.03 | 14 | 100017 | 532 | 50504561 |
Sensorimotor disorder | 22.92 | 10.03 | 13 | 100018 | 431 | 50504662 |
CYP3A4 polymorphism | 22.80 | 10.03 | 8 | 100023 | 80 | 50505013 |
Tachycardia paroxysmal | 22.78 | 10.03 | 11 | 100020 | 260 | 50504833 |
Psychotic symptom | 22.74 | 10.03 | 19 | 100012 | 1193 | 50503900 |
Orgasm abnormal | 22.71 | 10.03 | 8 | 100023 | 81 | 50505012 |
Injection site haemorrhage | 22.63 | 10.03 | 7 | 100024 | 21339 | 50483754 |
Salivary hypersecretion | 22.58 | 10.03 | 44 | 99987 | 6547 | 50498546 |
Cerebral ventricle dilatation | 22.54 | 10.03 | 17 | 100014 | 920 | 50504173 |
Respiratory disorder neonatal | 22.48 | 10.03 | 17 | 100014 | 924 | 50504169 |
Alkalosis hypochloraemic | 22.43 | 10.03 | 9 | 100022 | 134 | 50504959 |
Upper respiratory tract infection | 22.26 | 10.03 | 62 | 99969 | 65836 | 50439257 |
On and off phenomenon | 22.18 | 10.03 | 20 | 100011 | 1392 | 50503701 |
Non-cardiogenic pulmonary oedema | 22.16 | 10.03 | 14 | 100017 | 567 | 50504526 |
Orthostatic hypotension | 22.15 | 10.03 | 116 | 99915 | 29365 | 50475728 |
Platelet count decreased | 22.13 | 10.03 | 113 | 99918 | 100613 | 50404480 |
Osteoporosis | 22.12 | 10.03 | 34 | 99997 | 44845 | 50460248 |
Osteoarthritis | 22.11 | 10.03 | 66 | 99965 | 68540 | 50436553 |
Incoherent | 22.06 | 10.03 | 34 | 99997 | 4196 | 50500897 |
Suicidal behaviour | 21.86 | 10.03 | 25 | 100006 | 2309 | 50502784 |
Thirst | 21.84 | 10.03 | 58 | 99973 | 10592 | 50494501 |
Emotional disorder | 21.83 | 10.03 | 62 | 99969 | 11774 | 50493319 |
Abnormal weight gain | 21.70 | 10.03 | 20 | 100011 | 1432 | 50503661 |
Radial nerve palsy | 21.51 | 10.03 | 13 | 100018 | 486 | 50504607 |
Thymus disorder | 21.45 | 10.03 | 10 | 100021 | 218 | 50504875 |
Giant cell arteritis | 21.44 | 10.03 | 22 | 100009 | 1798 | 50503295 |
Pneumonia aspiration | 21.27 | 10.03 | 119 | 99912 | 30885 | 50474208 |
Breast discomfort | 21.07 | 10.03 | 12 | 100019 | 401 | 50504692 |
Fungal infection | 21.02 | 10.03 | 17 | 100014 | 29948 | 50475145 |
Neuropathy peripheral | 21.00 | 10.03 | 109 | 99922 | 96648 | 50408445 |
Bradykinesia | 20.99 | 10.03 | 32 | 99999 | 3911 | 50501182 |
Affective disorder | 20.77 | 10.03 | 37 | 99994 | 5144 | 50499949 |
Cerebellar syndrome | 20.72 | 10.03 | 29 | 100002 | 3282 | 50501811 |
Mutism | 20.60 | 10.03 | 19 | 100012 | 1362 | 50503731 |
Hypotonia | 20.58 | 10.03 | 48 | 99983 | 8086 | 50497007 |
Medication error | 20.56 | 10.03 | 132 | 99899 | 35972 | 50469121 |
Gamma-glutamyltransferase increased | 20.52 | 10.03 | 114 | 99917 | 29509 | 50475584 |
Natural killer cell count decreased | 20.52 | 10.03 | 6 | 100025 | 31 | 50505062 |
Therapy non-responder | 20.37 | 10.03 | 44 | 99987 | 50978 | 50454115 |
Infantile vomiting | 20.32 | 10.03 | 8 | 100023 | 113 | 50504980 |
Euphoric mood | 20.32 | 10.03 | 32 | 99999 | 4023 | 50501070 |
Hyperthermia | 20.12 | 10.03 | 46 | 99985 | 7650 | 50497443 |
Blood sodium decreased | 20.07 | 10.03 | 89 | 99942 | 21058 | 50484035 |
Cerebral mass effect | 19.97 | 10.03 | 15 | 100016 | 807 | 50504286 |
Stoma site discharge | 19.91 | 10.03 | 18 | 100013 | 1257 | 50503836 |
Blood pressure increased | 19.81 | 10.03 | 168 | 99863 | 132964 | 50372129 |
Bradyphrenia | 19.79 | 10.03 | 40 | 99991 | 6112 | 50498981 |
Postmortem blood drug level increased | 19.67 | 10.03 | 13 | 100018 | 569 | 50504524 |
Apathy | 19.60 | 10.03 | 45 | 99986 | 7503 | 50497590 |
Bradycardia neonatal | 19.58 | 10.03 | 15 | 100016 | 831 | 50504262 |
Thinking abnormal | 19.51 | 10.03 | 52 | 99979 | 9515 | 50495578 |
Hepatocellular injury | 19.43 | 10.03 | 102 | 99929 | 25845 | 50479248 |
Akinesia | 19.27 | 10.03 | 19 | 100012 | 1480 | 50503613 |
Hallucination, synaesthetic | 19.23 | 10.03 | 6 | 100025 | 40 | 50505053 |
Neonatal seizure | 19.22 | 10.03 | 11 | 100020 | 371 | 50504722 |
Activation syndrome | 19.14 | 10.03 | 9 | 100022 | 200 | 50504893 |
Purple glove syndrome | 18.98 | 10.03 | 9 | 100022 | 204 | 50504889 |
Foetal exposure during pregnancy | 18.76 | 10.03 | 105 | 99926 | 27254 | 50477839 |
Cataract | 18.71 | 10.03 | 41 | 99990 | 47259 | 50457834 |
Retinal detachment | 18.51 | 10.03 | 35 | 99996 | 5094 | 50499999 |
Sialoadenitis | 18.47 | 10.03 | 18 | 100013 | 1382 | 50503711 |
Nephrolithiasis | 18.36 | 10.03 | 25 | 100006 | 34668 | 50470425 |
Mental impairment | 18.36 | 10.03 | 59 | 99972 | 11985 | 50493108 |
Tachyphrenia | 18.32 | 10.03 | 17 | 100014 | 1228 | 50503865 |
Mental disorder | 18.26 | 10.03 | 89 | 99942 | 21902 | 50483191 |
Drop attacks | 18.16 | 10.03 | 13 | 100018 | 649 | 50504444 |
Vitamin B12 decreased | 18.13 | 10.03 | 25 | 100006 | 2790 | 50502303 |
Skin exfoliation | 18.01 | 10.03 | 24 | 100007 | 33588 | 50471505 |
Tinnitus | 18.00 | 10.03 | 106 | 99925 | 28026 | 50477067 |
Illusion | 17.92 | 10.03 | 15 | 100016 | 944 | 50504149 |
Red blood cell sedimentation rate increased | 17.90 | 10.03 | 19 | 100012 | 29397 | 50475696 |
Acute abdomen | 17.88 | 10.03 | 18 | 100013 | 1438 | 50503655 |
Cellulitis orbital | 17.83 | 10.03 | 11 | 100020 | 427 | 50504666 |
Rhinorrhoea | 17.81 | 10.03 | 48 | 99983 | 51535 | 50453558 |
Tongue movement disturbance | 17.75 | 10.03 | 9 | 100022 | 237 | 50504856 |
Pyroglutamic acidosis | 17.71 | 10.03 | 11 | 100020 | 432 | 50504661 |
Serum serotonin increased | 17.65 | 10.03 | 8 | 100023 | 163 | 50504930 |
Spina bifida | 17.56 | 10.03 | 13 | 100018 | 684 | 50504409 |
Suspected suicide | 17.44 | 10.03 | 35 | 99996 | 5322 | 50499771 |
Agonal rhythm | 17.40 | 10.03 | 5 | 100026 | 24 | 50505069 |
Snoring | 17.37 | 10.03 | 27 | 100004 | 3357 | 50501736 |
Drug dose titration not performed | 17.25 | 10.03 | 11 | 100020 | 453 | 50504640 |
Compulsive shopping | 17.21 | 10.03 | 13 | 100018 | 705 | 50504388 |
Brief psychotic disorder with marked stressors | 17.19 | 10.03 | 6 | 100025 | 59 | 50505034 |
Cytomegalovirus infection | 17.14 | 10.03 | 7 | 100024 | 17955 | 50487138 |
Bundle branch block right | 17.14 | 10.03 | 32 | 99999 | 4613 | 50500480 |
Respiratory distress | 17.14 | 10.03 | 21 | 100010 | 30468 | 50474625 |
Negative thoughts | 17.13 | 10.03 | 14 | 100017 | 852 | 50504241 |
Febrile neutropenia | 16.99 | 10.03 | 118 | 99913 | 97549 | 50407544 |
Tearfulness | 16.98 | 10.03 | 28 | 100003 | 3659 | 50501434 |
Merycism | 16.81 | 10.03 | 8 | 100023 | 183 | 50504910 |
Reduced facial expression | 16.52 | 10.03 | 18 | 100013 | 1576 | 50503517 |
Chest pain | 16.51 | 10.03 | 248 | 99783 | 176634 | 50328459 |
Dementia | 16.47 | 10.03 | 69 | 99962 | 15928 | 50489165 |
Joint range of motion decreased | 16.43 | 10.03 | 8 | 100023 | 18504 | 50486589 |
Aptyalism | 16.40 | 10.03 | 11 | 100020 | 494 | 50504599 |
Status epilepticus | 16.36 | 10.03 | 61 | 99970 | 13345 | 50491748 |
Medulloblastoma | 16.33 | 10.03 | 5 | 100026 | 31 | 50505062 |
Alcoholism | 16.28 | 10.03 | 18 | 100013 | 1602 | 50503491 |
Skin ulcer | 16.24 | 10.03 | 28 | 100003 | 35290 | 50469803 |
Binge eating | 16.24 | 10.03 | 10 | 100021 | 387 | 50504706 |
Bursitis | 16.24 | 10.03 | 12 | 100019 | 22123 | 50482970 |
Personality disorder | 16.22 | 10.03 | 30 | 100001 | 4294 | 50500799 |
Pulmonary renal syndrome | 16.17 | 10.03 | 10 | 100021 | 390 | 50504703 |
Dry mouth | 16.12 | 10.03 | 176 | 99855 | 56002 | 50449091 |
Vertigo | 16.10 | 10.03 | 165 | 99866 | 51667 | 50453426 |
Inflammation | 16.09 | 10.03 | 58 | 99973 | 56854 | 50448239 |
Empty sella syndrome | 16.07 | 10.03 | 5 | 100026 | 33 | 50505060 |
Sneezing | 16.01 | 10.03 | 4 | 100027 | 14040 | 50491053 |
Anaphylactic reaction | 16.01 | 10.03 | 54 | 99977 | 54001 | 50451092 |
Bulimia nervosa | 16.01 | 10.03 | 10 | 100021 | 397 | 50504696 |
Stoma site inflammation | 16.01 | 10.03 | 10 | 100021 | 397 | 50504696 |
Injection site rash | 15.94 | 10.03 | 6 | 100025 | 16171 | 50488922 |
Premature delivery | 15.89 | 10.03 | 14 | 100017 | 23649 | 50481444 |
Obsessive-compulsive symptom | 15.81 | 10.03 | 5 | 100026 | 35 | 50505058 |
Respiratory depression | 15.80 | 10.03 | 56 | 99975 | 11954 | 50493139 |
Hypothermia | 15.79 | 10.03 | 56 | 99975 | 11960 | 50493133 |
Myocardial infarction | 15.77 | 10.03 | 107 | 99924 | 88920 | 50416173 |
COVID-19 | 15.68 | 10.03 | 44 | 99987 | 46618 | 50458475 |
Cardiac failure congestive | 15.66 | 10.03 | 100 | 99931 | 84282 | 50420811 |
Drowning | 15.65 | 10.03 | 10 | 100021 | 413 | 50504680 |
Neck pain | 15.58 | 10.03 | 59 | 99972 | 57008 | 50448085 |
Homicidal ideation | 15.55 | 10.03 | 18 | 100013 | 1684 | 50503409 |
Gastrooesophageal reflux disease | 15.54 | 10.03 | 88 | 99943 | 76340 | 50428753 |
Premature labour | 15.52 | 10.03 | 54 | 99977 | 11422 | 50493671 |
Cardiac hypertrophy | 15.52 | 10.03 | 14 | 100017 | 975 | 50504118 |
Parkinsonian gait | 15.25 | 10.03 | 10 | 100021 | 432 | 50504661 |
Aspergillus test positive | 15.25 | 10.03 | 9 | 100022 | 322 | 50504771 |
Pulse absent | 15.17 | 10.03 | 31 | 100000 | 4775 | 50500318 |
Decubitus ulcer | 15.15 | 10.03 | 47 | 99984 | 9371 | 50495722 |
Resuscitation | 15.14 | 10.03 | 14 | 100017 | 1007 | 50504086 |
Blood cholesterol increased | 15.13 | 10.03 | 57 | 99974 | 55158 | 50449935 |
Parkinson's disease | 15.09 | 10.03 | 15 | 100016 | 1180 | 50503913 |
Post-traumatic stress disorder | 15.08 | 10.03 | 29 | 100002 | 4274 | 50500819 |
Hyperreflexia | 14.97 | 10.03 | 32 | 99999 | 5086 | 50500007 |
Hypotension | 14.95 | 10.03 | 588 | 99443 | 234881 | 50270212 |
Stupor | 14.90 | 10.03 | 26 | 100005 | 3557 | 50501536 |
Faecaloma | 14.87 | 10.03 | 39 | 99992 | 7069 | 50498024 |
Therapeutic response decreased | 14.81 | 10.03 | 46 | 99985 | 47185 | 50457908 |
Loss of libido | 14.80 | 10.03 | 15 | 100016 | 1208 | 50503885 |
Pneumonia | 14.73 | 10.03 | 605 | 99426 | 377796 | 50127297 |
Neglect of personal appearance | 14.73 | 10.03 | 6 | 100025 | 93 | 50505000 |
Substance abuse | 14.71 | 10.03 | 28 | 100003 | 4096 | 50500997 |
Basophil count decreased | 14.62 | 10.03 | 6 | 100025 | 95 | 50504998 |
Product quality issue | 14.62 | 10.03 | 24 | 100007 | 30834 | 50474259 |
Palmar-plantar erythrodysaesthesia syndrome | 14.61 | 10.03 | 11 | 100020 | 20087 | 50485006 |
Enterococcus test positive | 14.53 | 10.03 | 14 | 100017 | 1060 | 50504033 |
Viral infection | 14.51 | 10.03 | 23 | 100008 | 29963 | 50475130 |
Granulocytopenia neonatal | 14.51 | 10.03 | 4 | 100027 | 16 | 50505077 |
Antidepressant drug level increased | 14.45 | 10.03 | 8 | 100023 | 253 | 50504840 |
Psychiatric decompensation | 14.44 | 10.03 | 15 | 100016 | 1243 | 50503850 |
Drug reaction with eosinophilia and systemic symptoms | 14.43 | 10.03 | 101 | 99930 | 28323 | 50476770 |
Dyspraxia | 14.39 | 10.03 | 8 | 100023 | 255 | 50504838 |
Vasodilatation | 14.32 | 10.03 | 20 | 100011 | 2259 | 50502834 |
Skull fracture | 14.32 | 10.03 | 13 | 100018 | 913 | 50504180 |
Mixed anxiety and depressive disorder | 14.29 | 10.03 | 7 | 100024 | 171 | 50504922 |
Spontaneous haemorrhage | 14.22 | 10.03 | 8 | 100023 | 261 | 50504832 |
No adverse event | 14.21 | 10.03 | 28 | 100003 | 33550 | 50471543 |
Balance disorder | 14.20 | 10.03 | 207 | 99824 | 70383 | 50434710 |
Vagus nerve disorder | 14.18 | 10.03 | 6 | 100025 | 103 | 50504990 |
Intrusive thoughts | 14.14 | 10.03 | 7 | 100024 | 175 | 50504918 |
Shared psychotic disorder | 14.13 | 10.03 | 4 | 100027 | 18 | 50505075 |
Developmental hip dysplasia | 14.12 | 10.03 | 15 | 100016 | 1276 | 50503817 |
Catatonia | 14.11 | 10.03 | 26 | 100005 | 3710 | 50501383 |
Refusal of treatment by patient | 14.10 | 10.03 | 31 | 100000 | 5022 | 50500071 |
Pulmonary vein occlusion | 14.07 | 10.03 | 6 | 100025 | 105 | 50504988 |
Productive cough | 14.05 | 10.03 | 55 | 99976 | 52639 | 50452454 |
Logorrhoea | 14.02 | 10.03 | 20 | 100011 | 2304 | 50502789 |
Sinus tachycardia | 14.01 | 10.03 | 81 | 99950 | 21273 | 50483820 |
Interstitial lung disease | 13.86 | 10.03 | 56 | 99975 | 53120 | 50451973 |
B-lymphocyte count increased | 13.82 | 10.03 | 6 | 100025 | 110 | 50504983 |
Blood pressure diastolic decreased | 13.80 | 10.03 | 8 | 100023 | 16773 | 50488320 |
Influenza | 13.76 | 10.03 | 112 | 99919 | 89426 | 50415667 |
Dystrophic calcification | 13.72 | 10.03 | 6 | 100025 | 112 | 50504981 |
Orthostatic intolerance | 13.71 | 10.03 | 13 | 100018 | 965 | 50504128 |
Flushing | 13.71 | 10.03 | 77 | 99954 | 66938 | 50438155 |
False positive investigation result | 13.69 | 10.03 | 10 | 100021 | 515 | 50504578 |
Stoma site hypergranulation | 13.69 | 10.03 | 8 | 100023 | 281 | 50504812 |
Indifference | 13.67 | 10.03 | 6 | 100025 | 113 | 50504980 |
Intestinal mucosal atrophy | 13.61 | 10.03 | 3 | 100028 | 3 | 50505090 |
Compulsive sexual behaviour | 13.51 | 10.03 | 5 | 100026 | 59 | 50505034 |
Congenital hand malformation | 13.48 | 10.03 | 8 | 100023 | 289 | 50504804 |
Dysdiadochokinesis | 13.48 | 10.03 | 6 | 100025 | 117 | 50504976 |
Retrograde amnesia | 13.46 | 10.03 | 9 | 100022 | 402 | 50504691 |
Diarrhoea | 13.42 | 10.03 | 992 | 99039 | 587484 | 49917609 |
Fluid retention | 13.42 | 10.03 | 53 | 99978 | 50596 | 50454497 |
Polydipsia psychogenic | 13.36 | 10.03 | 5 | 100026 | 61 | 50505032 |
Paranasal sinus inflammation | 13.34 | 10.03 | 9 | 100022 | 408 | 50504685 |
Basal cell carcinoma | 13.22 | 10.03 | 16 | 100015 | 23340 | 50481753 |
Optic nerve disorder | 13.20 | 10.03 | 11 | 100020 | 688 | 50504405 |
Hyperacusis | 13.12 | 10.03 | 17 | 100014 | 1787 | 50503306 |
Bronchitis | 13.11 | 10.03 | 137 | 99894 | 104022 | 50401071 |
Long QT syndrome | 12.95 | 10.03 | 22 | 100009 | 2945 | 50502148 |
Rabbit syndrome | 12.93 | 10.03 | 8 | 100023 | 312 | 50504781 |
Selective eating disorder | 12.91 | 10.03 | 17 | 100014 | 1815 | 50503278 |
Gait disturbance | 12.89 | 10.03 | 388 | 99643 | 149617 | 50355476 |
Maternal drugs affecting foetus | 12.89 | 10.03 | 30 | 100001 | 5047 | 50500046 |
Lower limb fracture | 12.89 | 10.03 | 6 | 100025 | 14240 | 50490853 |
Insomnia | 12.87 | 10.03 | 444 | 99587 | 174421 | 50330672 |
Systemic infection | 12.83 | 10.03 | 19 | 100012 | 2264 | 50502829 |
Essential tremor | 12.79 | 10.03 | 12 | 100019 | 879 | 50504214 |
Increased appetite | 12.78 | 10.03 | 41 | 99990 | 8320 | 50496773 |
Skin necrosis | 12.58 | 10.03 | 3 | 100028 | 10864 | 50494229 |
Nail avulsion | 12.57 | 10.03 | 6 | 100025 | 138 | 50504955 |
Dreamy state | 12.53 | 10.03 | 4 | 100027 | 29 | 50505064 |
Glassy eyes | 12.49 | 10.03 | 5 | 100026 | 74 | 50505019 |
Chemical burns of eye | 12.49 | 10.03 | 5 | 100026 | 74 | 50505019 |
Kussmaul respiration | 12.48 | 10.03 | 7 | 100024 | 227 | 50504866 |
Sinus congestion | 12.46 | 10.03 | 6 | 100025 | 13965 | 50491128 |
Gambling | 12.43 | 10.03 | 7 | 100024 | 229 | 50504864 |
Fibula agenesis | 12.40 | 10.03 | 3 | 100028 | 6 | 50505087 |
Phaeochromocytoma | 12.40 | 10.03 | 9 | 100022 | 459 | 50504634 |
Visual acuity reduced transiently | 12.38 | 10.03 | 6 | 100025 | 143 | 50504950 |
Transfusion | 12.36 | 10.03 | 5 | 100026 | 12900 | 50492193 |
Tendonitis | 12.32 | 10.03 | 9 | 100022 | 16696 | 50488397 |
Lipohypertrophy | 12.32 | 10.03 | 10 | 100021 | 603 | 50504490 |
Abdominal rigidity | 12.30 | 10.03 | 16 | 100015 | 1688 | 50503405 |
Injection site warmth | 12.30 | 10.03 | 6 | 100025 | 13860 | 50491233 |
Peripheral paralysis | 12.25 | 10.03 | 5 | 100026 | 78 | 50505015 |
Polyneuropathy | 12.23 | 10.03 | 52 | 99979 | 12079 | 50493014 |
Poor feeding infant | 12.21 | 10.03 | 7 | 100024 | 237 | 50504856 |
Bipolar I disorder | 12.14 | 10.03 | 15 | 100016 | 1503 | 50503590 |
Agoraphobia | 12.13 | 10.03 | 8 | 100023 | 349 | 50504744 |
Formication | 12.08 | 10.03 | 24 | 100007 | 3622 | 50501471 |
Dyspnoea at rest | 12.08 | 10.03 | 24 | 100007 | 3623 | 50501470 |
Tenosynovitis | 12.06 | 10.03 | 3 | 100028 | 10562 | 50494531 |
Haemoptysis | 12.01 | 10.03 | 20 | 100011 | 25553 | 50479540 |
Cerebellar haematoma | 11.97 | 10.03 | 8 | 100023 | 357 | 50504736 |
Motor dysfunction | 11.93 | 10.03 | 39 | 99992 | 7992 | 50497101 |
Extensor plantar response | 11.91 | 10.03 | 13 | 100018 | 1141 | 50503952 |
Inappropriate affect | 11.84 | 10.03 | 11 | 100020 | 796 | 50504297 |
Snake bite | 11.80 | 10.03 | 3 | 100028 | 8 | 50505085 |
Antiphospholipid antibodies | 11.77 | 10.03 | 6 | 100025 | 160 | 50504933 |
C-reactive protein increased | 11.72 | 10.03 | 80 | 99951 | 66394 | 50438699 |
Disseminated intravascular coagulation | 11.67 | 10.03 | 10 | 100021 | 17125 | 50487968 |
Staphylococcal infection | 11.66 | 10.03 | 34 | 99997 | 35582 | 50469511 |
Anticholinergic syndrome | 11.65 | 10.03 | 16 | 100015 | 1779 | 50503314 |
Migraine | 11.64 | 10.03 | 94 | 99937 | 75186 | 50429907 |
Macular degeneration | 11.63 | 10.03 | 7 | 100024 | 14381 | 50490712 |
Product confusion | 11.54 | 10.03 | 3 | 100028 | 9 | 50505084 |
Generalised anxiety disorder | 11.48 | 10.03 | 16 | 100015 | 1804 | 50503289 |
Freezing phenomenon | 11.47 | 10.03 | 12 | 100019 | 1003 | 50504090 |
Product complaint | 11.45 | 10.03 | 49 | 99982 | 11417 | 50493676 |
Failure to thrive | 11.43 | 10.03 | 33 | 99998 | 6325 | 50498768 |
Product monitoring error | 11.42 | 10.03 | 20 | 100011 | 2744 | 50502349 |
Tic | 11.34 | 10.03 | 13 | 100018 | 1204 | 50503889 |
Potentiating drug interaction | 11.32 | 10.03 | 24 | 100007 | 3792 | 50501301 |
Somnambulism | 11.32 | 10.03 | 28 | 100003 | 4896 | 50500197 |
Upper gastrointestinal haemorrhage | 11.30 | 10.03 | 62 | 99969 | 15973 | 50489120 |
Mucosal inflammation | 11.29 | 10.03 | 41 | 99990 | 40101 | 50464992 |
Injection site urticaria | 11.28 | 10.03 | 5 | 100026 | 12212 | 50492881 |
Central nervous system inflammation | 11.24 | 10.03 | 6 | 100025 | 176 | 50504917 |
Anaphylactic shock | 11.20 | 10.03 | 14 | 100017 | 20141 | 50484952 |
Paraesthesia | 11.15 | 10.03 | 314 | 99717 | 119929 | 50385164 |
Sinus disorder | 11.15 | 10.03 | 12 | 100019 | 18446 | 50486647 |
Bipolar disorder | 11.13 | 10.03 | 34 | 99997 | 6723 | 50498370 |
Heart rate decreased | 11.13 | 10.03 | 36 | 99995 | 36461 | 50468632 |
Infantile apnoea | 11.10 | 10.03 | 11 | 100020 | 862 | 50504231 |
Antipsychotic drug level below therapeutic | 11.02 | 10.03 | 7 | 100024 | 286 | 50504807 |
Pyrexia | 11.02 | 10.03 | 627 | 99404 | 379576 | 50125517 |
Rash pruritic | 10.89 | 10.03 | 53 | 99978 | 47793 | 50457300 |
Sleep terror | 10.89 | 10.03 | 10 | 100021 | 713 | 50504380 |
Somatic delusion | 10.88 | 10.03 | 9 | 100022 | 557 | 50504536 |
Post viral fatigue syndrome | 10.83 | 10.03 | 7 | 100024 | 295 | 50504798 |
Ear pain | 10.79 | 10.03 | 25 | 100006 | 28258 | 50476835 |
Blood pressure systolic increased | 10.78 | 10.03 | 35 | 99996 | 35414 | 50469679 |
Secretion discharge | 10.76 | 10.03 | 3 | 100028 | 9788 | 50495305 |
Creatinine renal clearance decreased | 10.75 | 10.03 | 5 | 100026 | 11876 | 50493217 |
Skin lesion | 10.71 | 10.03 | 23 | 100008 | 26704 | 50478389 |
Neuropsychiatric symptoms | 10.71 | 10.03 | 9 | 100022 | 570 | 50504523 |
Ear infection | 10.70 | 10.03 | 22 | 100009 | 25948 | 50479145 |
Adrenal cyst | 10.68 | 10.03 | 5 | 100026 | 110 | 50504983 |
Arachnoid cyst | 10.63 | 10.03 | 6 | 100025 | 197 | 50504896 |
Pulmonary haematoma | 10.60 | 10.03 | 4 | 100027 | 50 | 50505043 |
Hypernatraemia | 10.59 | 10.03 | 32 | 99999 | 6289 | 50498804 |
Acne | 10.49 | 10.03 | 14 | 100017 | 19581 | 50485512 |
Hyperphagia | 10.46 | 10.03 | 14 | 100017 | 1518 | 50503575 |
Pharyngeal erythema | 10.46 | 10.03 | 14 | 100017 | 1518 | 50503575 |
Exostosis | 10.40 | 10.03 | 5 | 100026 | 11648 | 50493445 |
Compulsions | 10.39 | 10.03 | 6 | 100025 | 206 | 50504887 |
Musculoskeletal stiffness | 10.37 | 10.03 | 185 | 99846 | 128296 | 50376797 |
Ocular hyperaemia | 10.36 | 10.03 | 15 | 100016 | 20277 | 50484816 |
Decreased interest | 10.36 | 10.03 | 20 | 100011 | 2956 | 50502137 |
Bradycardia | 10.35 | 10.03 | 182 | 99849 | 64244 | 50440849 |
Dyspnoea | 10.35 | 10.03 | 937 | 99094 | 546671 | 49958422 |
Poverty of thought content | 10.34 | 10.03 | 3 | 100028 | 15 | 50505078 |
Gamma-glutamyltransferase abnormal | 10.34 | 10.03 | 6 | 100025 | 208 | 50504885 |
Oropharyngeal pain | 10.34 | 10.03 | 101 | 99930 | 77700 | 50427393 |
Abdominal pain upper | 10.30 | 10.03 | 238 | 99793 | 159071 | 50346022 |
Glomerular filtration rate decreased | 10.28 | 10.03 | 48 | 99983 | 11604 | 50493489 |
Electrocardiogram T wave inversion | 10.25 | 10.03 | 21 | 100010 | 3240 | 50501853 |
Rash erythematous | 10.20 | 10.03 | 35 | 99996 | 34817 | 50470276 |
Acquired epidermolysis bullosa | 10.19 | 10.03 | 4 | 100027 | 56 | 50505037 |
Ataxia | 10.19 | 10.03 | 54 | 99977 | 13732 | 50491361 |
Communication disorder | 10.18 | 10.03 | 17 | 100014 | 2244 | 50502849 |
Postural tremor | 10.16 | 10.03 | 6 | 100025 | 215 | 50504878 |
Bifascicular block | 10.10 | 10.03 | 5 | 100026 | 125 | 50504968 |
Large for dates baby | 10.08 | 10.03 | 8 | 100023 | 467 | 50504626 |
Drug withdrawal headache | 10.07 | 10.03 | 4 | 100027 | 58 | 50505035 |
Granulocyte percentage | 10.07 | 10.03 | 4 | 100027 | 58 | 50505035 |
Arrhythmia | 10.06 | 10.03 | 105 | 99926 | 33027 | 50472066 |
HIV-associated neurocognitive disorder | 10.06 | 10.03 | 5 | 100026 | 126 | 50504967 |
Dissociative disorder | 10.06 | 10.03 | 6 | 100025 | 219 | 50504874 |
Blood pressure diastolic abnormal | 10.05 | 10.03 | 3 | 100028 | 9358 | 50495735 |
Crying | 10.04 | 10.03 | 72 | 99959 | 20344 | 50484749 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Toxicity to various agents | 460.59 | 10.57 | 1153 | 67984 | 172508 | 29332882 |
Intentional overdose | 429.51 | 10.57 | 489 | 68648 | 38039 | 29467351 |
Intentional self-injury | 356.29 | 10.57 | 268 | 68869 | 12193 | 29493197 |
Completed suicide | 333.15 | 10.57 | 684 | 68453 | 89562 | 29415828 |
Suicide attempt | 325.56 | 10.57 | 400 | 68737 | 33710 | 29471680 |
Agitation | 269.75 | 10.57 | 453 | 68684 | 50851 | 29454539 |
Serotonin syndrome | 243.60 | 10.57 | 250 | 68887 | 17262 | 29488128 |
Suicidal ideation | 238.84 | 10.57 | 347 | 68790 | 34369 | 29471021 |
Somnolence | 213.63 | 10.57 | 590 | 68547 | 93365 | 29412025 |
Confusional state | 203.46 | 10.57 | 709 | 68428 | 127168 | 29378222 |
Overdose | 203.44 | 10.57 | 523 | 68614 | 79296 | 29426094 |
Drug abuse | 177.92 | 10.57 | 498 | 68639 | 79385 | 29426005 |
Sopor | 175.92 | 10.57 | 169 | 68968 | 10765 | 29494625 |
Coma | 148.78 | 10.57 | 302 | 68835 | 39148 | 29466242 |
Restlessness | 147.39 | 10.57 | 218 | 68919 | 21927 | 29483463 |
Anxiety | 127.58 | 10.57 | 464 | 68673 | 84901 | 29420489 |
Extrapyramidal disorder | 111.36 | 10.57 | 132 | 69005 | 10699 | 29494691 |
Sedation | 108.21 | 10.57 | 166 | 68971 | 17239 | 29488151 |
Aggression | 106.49 | 10.57 | 248 | 68889 | 35293 | 29470097 |
Restless legs syndrome | 103.10 | 10.57 | 103 | 69034 | 6881 | 29498509 |
Fall | 102.07 | 10.57 | 736 | 68401 | 176442 | 29328948 |
Drug interaction | 98.64 | 10.57 | 793 | 68344 | 196592 | 29308798 |
Delirium | 95.96 | 10.57 | 254 | 68883 | 39143 | 29466247 |
Nightmare | 93.22 | 10.57 | 124 | 69013 | 11293 | 29494097 |
Hallucination, visual | 91.64 | 10.57 | 142 | 68995 | 14873 | 29490517 |
Drug withdrawal syndrome | 88.07 | 10.57 | 154 | 68983 | 17830 | 29487560 |
Neuroleptic malignant syndrome | 86.62 | 10.57 | 144 | 68993 | 16004 | 29489386 |
Accidental overdose | 86.61 | 10.57 | 151 | 68986 | 17442 | 29487948 |
Intrusive thoughts | 84.26 | 10.57 | 29 | 69108 | 226 | 29505164 |
Febrile neutropenia | 82.94 | 10.57 | 84 | 69053 | 112156 | 29393234 |
Depressed mood | 82.04 | 10.57 | 142 | 68995 | 16306 | 29489084 |
Electrocardiogram QT prolonged | 80.03 | 10.57 | 225 | 68912 | 35912 | 29469478 |
Mania | 78.40 | 10.57 | 99 | 69038 | 8564 | 29496826 |
Tremor | 77.51 | 10.57 | 359 | 68778 | 73179 | 29432211 |
Parkinsonism | 72.02 | 10.57 | 87 | 69050 | 7191 | 29498199 |
Wrong patient received product | 71.76 | 10.57 | 52 | 69085 | 2230 | 29503160 |
Withdrawal syndrome | 71.38 | 10.57 | 107 | 69030 | 10885 | 29494505 |
Insomnia | 68.99 | 10.57 | 398 | 68739 | 88363 | 29417027 |
Dyskinesia | 67.91 | 10.57 | 147 | 68990 | 19914 | 29485476 |
Logorrhoea | 67.12 | 10.57 | 50 | 69087 | 2238 | 29503152 |
Bradyphrenia | 65.64 | 10.57 | 64 | 69073 | 4150 | 29501240 |
Disorientation | 65.57 | 10.57 | 184 | 68953 | 29331 | 29476059 |
Depressed level of consciousness | 64.86 | 10.57 | 212 | 68925 | 36730 | 29468660 |
Abnormal behaviour | 63.45 | 10.57 | 156 | 68981 | 22971 | 29482419 |
Pneumonia aspiration | 61.10 | 10.57 | 207 | 68930 | 36530 | 29468860 |
Hallucination, auditory | 60.33 | 10.57 | 92 | 69045 | 9501 | 29495889 |
Myoclonus | 60.07 | 10.57 | 110 | 69027 | 13199 | 29492191 |
Muscle twitching | 59.21 | 10.57 | 83 | 69054 | 7943 | 29497447 |
Depression | 58.64 | 10.57 | 370 | 68767 | 84777 | 29420613 |
Paranoia | 58.31 | 10.57 | 92 | 69045 | 9785 | 29495605 |
Psychotic disorder | 56.58 | 10.57 | 138 | 68999 | 20216 | 29485174 |
Hallucination | 55.24 | 10.57 | 229 | 68908 | 44483 | 29460907 |
Psychomotor hyperactivity | 54.83 | 10.57 | 81 | 69056 | 8132 | 29497258 |
Akathisia | 54.69 | 10.57 | 73 | 69064 | 6669 | 29498721 |
Interstitial lung disease | 52.77 | 10.57 | 35 | 69102 | 57683 | 29447707 |
Apathy | 51.88 | 10.57 | 68 | 69069 | 6103 | 29499287 |
Delusion | 51.00 | 10.57 | 93 | 69044 | 11123 | 29494267 |
Homicidal ideation | 50.31 | 10.57 | 44 | 69093 | 2480 | 29502910 |
Tachycardia | 50.06 | 10.57 | 315 | 68822 | 72095 | 29433295 |
Antidepressant drug level above therapeutic | 49.93 | 10.57 | 18 | 69119 | 163 | 29505227 |
Panic attack | 49.76 | 10.57 | 78 | 69059 | 8248 | 29497142 |
Inappropriate antidiuretic hormone secretion | 48.89 | 10.57 | 90 | 69047 | 10842 | 29494548 |
Pruritus | 47.53 | 10.57 | 129 | 69008 | 116720 | 29388670 |
Tachyphrenia | 47.03 | 10.57 | 31 | 69106 | 1138 | 29504252 |
Muscle rigidity | 46.60 | 10.57 | 81 | 69056 | 9330 | 29496060 |
Sleep disorder | 46.50 | 10.57 | 144 | 68993 | 24242 | 29481148 |
Disturbance in attention | 46.06 | 10.57 | 132 | 69005 | 21292 | 29484098 |
Bradykinesia | 45.73 | 10.57 | 48 | 69089 | 3399 | 29501991 |
Poisoning | 45.61 | 10.57 | 83 | 69054 | 9910 | 29495480 |
Hypomania | 45.55 | 10.57 | 39 | 69098 | 2136 | 29503254 |
On and off phenomenon | 45.41 | 10.57 | 37 | 69100 | 1891 | 29503499 |
Platelet count decreased | 45.29 | 10.57 | 112 | 69025 | 104560 | 29400830 |
Loss of consciousness | 45.03 | 10.57 | 312 | 68825 | 73744 | 29431646 |
Myocardial infarction | 43.20 | 10.57 | 124 | 69013 | 110172 | 29395218 |
Illusion | 42.03 | 10.57 | 24 | 69113 | 678 | 29504712 |
Priapism | 41.74 | 10.57 | 52 | 69085 | 4436 | 29500954 |
Off label use | 40.66 | 10.57 | 479 | 68658 | 300321 | 29205069 |
Nasopharyngitis | 40.34 | 10.57 | 48 | 69089 | 59617 | 29445773 |
Illness anxiety disorder | 39.78 | 10.57 | 15 | 69122 | 156 | 29505234 |
Antipsychotic drug level above therapeutic | 39.04 | 10.57 | 27 | 69110 | 1074 | 29504316 |
Poisoning deliberate | 38.95 | 10.57 | 57 | 69080 | 5674 | 29499716 |
Disease progression | 38.36 | 10.57 | 84 | 69053 | 81832 | 29423558 |
Neuropathy peripheral | 38.31 | 10.57 | 67 | 69070 | 70960 | 29434430 |
Systemic infection | 36.70 | 10.57 | 34 | 69103 | 2067 | 29503323 |
Mood swings | 36.67 | 10.57 | 63 | 69074 | 7188 | 29498202 |
Altered state of consciousness | 36.58 | 10.57 | 116 | 69021 | 19773 | 29485617 |
Pulmonary congestion | 36.37 | 10.57 | 86 | 69051 | 12350 | 29493040 |
Cough | 36.00 | 10.57 | 163 | 68974 | 126564 | 29378826 |
Dystonia | 35.96 | 10.57 | 74 | 69063 | 9675 | 29495715 |
Anger | 35.94 | 10.57 | 79 | 69058 | 10811 | 29494579 |
Pneumonia | 35.89 | 10.57 | 530 | 68607 | 319642 | 29185748 |
Vestibular disorder | 35.40 | 10.57 | 25 | 69112 | 1029 | 29504361 |
Renal failure | 35.23 | 10.57 | 150 | 68987 | 118449 | 29386941 |
Pyrexia | 34.38 | 10.57 | 470 | 68667 | 287152 | 29218238 |
Hyponatraemic coma | 33.91 | 10.57 | 9 | 69128 | 24 | 29505366 |
Tardive dyskinesia | 33.87 | 10.57 | 51 | 69086 | 5207 | 29500183 |
Analgesic drug level above therapeutic | 33.81 | 10.57 | 15 | 69122 | 243 | 29505147 |
Hyponatraemia | 33.77 | 10.57 | 272 | 68865 | 67361 | 29438029 |
Miosis | 33.40 | 10.57 | 64 | 69073 | 7945 | 29497445 |
Atrial fibrillation | 33.01 | 10.57 | 131 | 69006 | 105515 | 29399875 |
Drug dependence | 32.93 | 10.57 | 116 | 69021 | 20865 | 29484525 |
Rheumatoid arthritis | 32.92 | 10.57 | 17 | 69120 | 32135 | 29473255 |
Urogenital haemorrhage | 32.73 | 10.57 | 18 | 69119 | 472 | 29504918 |
Accidental death | 32.67 | 10.57 | 32 | 69105 | 2086 | 29503304 |
Persecutory delusion | 32.38 | 10.57 | 32 | 69105 | 2109 | 29503281 |
Urinary retention | 32.30 | 10.57 | 154 | 68983 | 31744 | 29473646 |
Mental disorder | 32.21 | 10.57 | 84 | 69053 | 12821 | 29492569 |
Infusion related reaction | 32.20 | 10.57 | 33 | 69104 | 43853 | 29461537 |
Blood creatine phosphokinase increased | 32.02 | 10.57 | 183 | 68954 | 40461 | 29464929 |
Aptyalism | 31.60 | 10.57 | 15 | 69122 | 286 | 29505104 |
Cardiac failure congestive | 31.53 | 10.57 | 84 | 69053 | 76497 | 29428893 |
Rash | 31.42 | 10.57 | 288 | 68849 | 189531 | 29315859 |
Thrombocytopenia | 31.21 | 10.57 | 186 | 68951 | 134637 | 29370753 |
Respiratory arrest | 30.87 | 10.57 | 131 | 69006 | 25702 | 29479688 |
Decreased gait velocity | 30.75 | 10.57 | 12 | 69125 | 138 | 29505252 |
Arthralgia | 30.56 | 10.57 | 196 | 68941 | 139421 | 29365969 |
Substance abuse | 30.50 | 10.57 | 56 | 69081 | 6731 | 29498659 |
Product prescribing error | 30.50 | 10.57 | 102 | 69035 | 17874 | 29487516 |
Rhabdomyolysis | 30.05 | 10.57 | 244 | 68893 | 60564 | 29444826 |
Catatonia | 29.73 | 10.57 | 44 | 69093 | 4424 | 29500966 |
Drug hypersensitivity | 29.72 | 10.57 | 73 | 69064 | 68333 | 29437057 |
Irritability | 29.37 | 10.57 | 116 | 69021 | 22036 | 29483354 |
Selective eating disorder | 29.22 | 10.57 | 27 | 69110 | 1636 | 29503754 |
Injection site pain | 29.21 | 10.57 | 20 | 69117 | 32426 | 29472964 |
Cytomegalovirus infection | 29.11 | 10.57 | 9 | 69128 | 23206 | 29482184 |
Pleural effusion | 28.75 | 10.57 | 80 | 69057 | 71828 | 29433562 |
Loss of libido | 28.74 | 10.57 | 31 | 69106 | 2265 | 29503125 |
Asphyxia | 27.96 | 10.57 | 47 | 69090 | 5268 | 29500122 |
Respiratory depression | 27.79 | 10.57 | 82 | 69055 | 13441 | 29491949 |
Herpes zoster | 27.76 | 10.57 | 18 | 69119 | 30034 | 29475356 |
Platypnoea | 27.69 | 10.57 | 8 | 69129 | 32 | 29505358 |
Drug ineffective | 27.61 | 10.57 | 643 | 68494 | 362527 | 29142863 |
Diarrhoea | 27.58 | 10.57 | 581 | 68556 | 332117 | 29173273 |
Electrocardiogram abnormal | 27.50 | 10.57 | 56 | 69081 | 7266 | 29498124 |
Stomatitis | 27.12 | 10.57 | 28 | 69109 | 37085 | 29468305 |
Feelings of worthlessness | 27.10 | 10.57 | 13 | 69124 | 254 | 29505136 |
Alcohol use | 27.09 | 10.57 | 35 | 69102 | 3097 | 29502293 |
Oesophageal obstruction | 26.85 | 10.57 | 15 | 69122 | 406 | 29504984 |
General physical health deterioration | 26.66 | 10.57 | 362 | 68775 | 102495 | 29402895 |
Prescription drug used without a prescription | 26.53 | 10.57 | 23 | 69114 | 1281 | 29504109 |
Dysarthria | 26.22 | 10.57 | 142 | 68995 | 30769 | 29474621 |
Sarcopenia | 26.13 | 10.57 | 14 | 69123 | 348 | 29505042 |
Feeling jittery | 25.95 | 10.57 | 37 | 69100 | 3596 | 29501794 |
Hyperhidrosis | 25.70 | 10.57 | 247 | 68890 | 64293 | 29441097 |
Macrophages increased | 25.62 | 10.57 | 11 | 69126 | 164 | 29505226 |
Hyperreflexia | 25.59 | 10.57 | 32 | 69105 | 2740 | 29502650 |
Hallucinations, mixed | 25.58 | 10.57 | 30 | 69107 | 2403 | 29502987 |
Depersonalisation/derealisation disorder | 24.82 | 10.57 | 16 | 69121 | 565 | 29504825 |
Asthma | 24.21 | 10.57 | 26 | 69111 | 33823 | 29471567 |
Benign gastrointestinal neoplasm | 24.18 | 10.57 | 10 | 69127 | 135 | 29505255 |
Mucosal inflammation | 24.05 | 10.57 | 23 | 69114 | 31572 | 29473818 |
Dysphoria | 24.03 | 10.57 | 27 | 69110 | 2065 | 29503325 |
Congenital cerebrovascular anomaly | 23.80 | 10.57 | 6 | 69131 | 12 | 29505378 |
Sepsis | 23.80 | 10.57 | 216 | 68921 | 142466 | 29362924 |
Postictal state | 23.58 | 10.57 | 17 | 69120 | 723 | 29504667 |
Product monitoring error | 23.57 | 10.57 | 30 | 69107 | 2615 | 29502775 |
Dementia with Lewy bodies | 23.46 | 10.57 | 16 | 69121 | 622 | 29504768 |
Erythema | 23.44 | 10.57 | 94 | 69043 | 75512 | 29429878 |
Urticaria | 23.22 | 10.57 | 59 | 69078 | 54601 | 29450789 |
Depressive symptom | 22.94 | 10.57 | 24 | 69113 | 1693 | 29503697 |
Product prescribing issue | 22.57 | 10.57 | 20 | 69117 | 1147 | 29504243 |
Circulatory collapse | 22.55 | 10.57 | 95 | 69042 | 18578 | 29486812 |
Pleurothotonus | 22.53 | 10.57 | 19 | 69118 | 1019 | 29504371 |
Cold sweat | 22.52 | 10.57 | 58 | 69079 | 8784 | 29496606 |
Slow speech | 22.46 | 10.57 | 18 | 69119 | 898 | 29504492 |
IVth nerve disorder | 22.09 | 10.57 | 6 | 69131 | 18 | 29505372 |
Arthritis | 21.76 | 10.57 | 16 | 69121 | 25003 | 29480387 |
Suspected suicide | 21.75 | 10.57 | 36 | 69101 | 3984 | 29501406 |
Cogwheel rigidity | 21.49 | 10.57 | 20 | 69117 | 1223 | 29504167 |
Mood altered | 21.49 | 10.57 | 54 | 69083 | 8057 | 29497333 |
Cardiac failure | 21.30 | 10.57 | 104 | 69033 | 79183 | 29426207 |
Bipolar disorder | 21.28 | 10.57 | 32 | 69105 | 3263 | 29502127 |
Dysgraphia | 21.21 | 10.57 | 25 | 69112 | 2013 | 29503377 |
Septic shock | 21.20 | 10.57 | 75 | 69062 | 62485 | 29442905 |
Acute kidney injury | 21.14 | 10.57 | 466 | 68671 | 264801 | 29240589 |
Activation syndrome | 20.58 | 10.57 | 8 | 69129 | 91 | 29505299 |
Pressure of speech | 20.53 | 10.57 | 13 | 69124 | 445 | 29504945 |
Alcoholism | 20.35 | 10.57 | 28 | 69109 | 2633 | 29502757 |
Hypertonia | 20.33 | 10.57 | 34 | 69103 | 3795 | 29501595 |
Parkinsonian gait | 20.27 | 10.57 | 13 | 69124 | 455 | 29504935 |
Congenital hyperinsulinaemic hypoglycaemia | 20.24 | 10.57 | 4 | 69133 | 0 | 29505390 |
Postoperative respiratory failure | 20.19 | 10.57 | 8 | 69129 | 96 | 29505294 |
Homicide | 20.17 | 10.57 | 17 | 69120 | 911 | 29504479 |
Nervousness | 19.93 | 10.57 | 65 | 69072 | 11241 | 29494149 |
Bezoar | 19.89 | 10.57 | 16 | 69121 | 803 | 29504587 |
Acute psychosis | 19.76 | 10.57 | 22 | 69115 | 1665 | 29503725 |
Perforated ulcer | 19.68 | 10.57 | 9 | 69128 | 157 | 29505233 |
Neutropenia | 19.59 | 10.57 | 205 | 68932 | 131506 | 29373884 |
Urinary hesitation | 19.56 | 10.57 | 25 | 69112 | 2188 | 29503202 |
Feeling guilty | 19.32 | 10.57 | 11 | 69126 | 309 | 29505081 |
Respiratory disorder neonatal | 19.18 | 10.57 | 20 | 69117 | 1405 | 29503985 |
Seizure | 19.15 | 10.57 | 315 | 68822 | 92808 | 29412582 |
Helplessness | 18.99 | 10.57 | 7 | 69130 | 68 | 29505322 |
Verbal abuse | 18.89 | 10.57 | 9 | 69128 | 173 | 29505217 |
Sinusitis | 18.88 | 10.57 | 32 | 69105 | 34318 | 29471072 |
Psychomotor skills impaired | 18.86 | 10.57 | 27 | 69110 | 2634 | 29502756 |
Myelodysplastic syndrome | 18.83 | 10.57 | 9 | 69128 | 17785 | 29487605 |
Myelosuppression | 18.83 | 10.57 | 3 | 69134 | 12224 | 29493166 |
Hanging | 18.71 | 10.57 | 8 | 69129 | 118 | 29505272 |
Peripheral swelling | 18.67 | 10.57 | 81 | 69056 | 63658 | 29441732 |
Tubulointerstitial nephritis | 18.55 | 10.57 | 9 | 69128 | 17634 | 29487756 |
Joint swelling | 18.54 | 10.57 | 57 | 69080 | 49573 | 29455817 |
COVID-19 | 18.49 | 10.57 | 35 | 69102 | 35979 | 29469411 |
Upper respiratory tract infection | 18.48 | 10.57 | 22 | 69115 | 27327 | 29478063 |
Mental impairment | 18.37 | 10.57 | 55 | 69082 | 9086 | 29496304 |
Amnestic disorder | 18.17 | 10.57 | 9 | 69128 | 189 | 29505201 |
Eosinophilic myocarditis | 18.14 | 10.57 | 12 | 69125 | 443 | 29504947 |
Respiratory tract infection | 18.02 | 10.57 | 7 | 69130 | 15644 | 29489746 |
Hypervigilance | 17.95 | 10.57 | 8 | 69129 | 131 | 29505259 |
Back pain | 17.85 | 10.57 | 153 | 68984 | 102131 | 29403259 |
Acute myocardial infarction | 17.83 | 10.57 | 56 | 69081 | 48382 | 29457008 |
Arachnoid cyst | 17.79 | 10.57 | 9 | 69128 | 198 | 29505192 |
Derealisation | 17.76 | 10.57 | 13 | 69124 | 566 | 29504824 |
Tracheal pain | 17.75 | 10.57 | 6 | 69131 | 44 | 29505346 |
White blood cell count decreased | 17.72 | 10.57 | 118 | 69019 | 83244 | 29422146 |
Dry skin | 17.70 | 10.57 | 17 | 69120 | 23290 | 29482100 |
Sudden cardiac death | 17.63 | 10.57 | 29 | 69108 | 3193 | 29502197 |
Eosinophilic pleural effusion | 17.63 | 10.57 | 9 | 69128 | 202 | 29505188 |
Temperature regulation disorder | 17.62 | 10.57 | 13 | 69124 | 573 | 29504817 |
Malignant neoplasm progression | 17.54 | 10.57 | 101 | 69036 | 73758 | 29431632 |
Antipsychotic drug level increased | 17.49 | 10.57 | 29 | 69108 | 3214 | 29502176 |
Fear of weight gain | 17.48 | 10.57 | 4 | 69133 | 4 | 29505386 |
Hangover | 17.43 | 10.57 | 16 | 69121 | 961 | 29504429 |
Inappropriate schedule of product administration | 17.38 | 10.57 | 50 | 69087 | 44422 | 29460968 |
Electrocardiogram QRS complex prolonged | 17.33 | 10.57 | 33 | 69104 | 4077 | 29501313 |
Implant site extravasation | 17.25 | 10.57 | 11 | 69126 | 381 | 29505009 |
Haemoglobin decreased | 17.22 | 10.57 | 166 | 68971 | 108209 | 29397181 |
Posture abnormal | 17.22 | 10.57 | 22 | 69115 | 1925 | 29503465 |
Intentional product use issue | 17.19 | 10.57 | 47 | 69090 | 42451 | 29462939 |
Alcohol interaction | 17.10 | 10.57 | 26 | 69111 | 2677 | 29502713 |
Progressive multifocal leukoencephalopathy | 17.09 | 10.57 | 52 | 69085 | 8667 | 29496723 |
Gait disturbance | 16.93 | 10.57 | 253 | 68884 | 73096 | 29432294 |
Mastication disorder | 16.92 | 10.57 | 17 | 69120 | 1143 | 29504247 |
Anaemia | 16.57 | 10.57 | 351 | 68786 | 200600 | 29304790 |
Ejaculation failure | 16.57 | 10.57 | 14 | 69123 | 753 | 29504637 |
Ataxia | 16.54 | 10.57 | 64 | 69073 | 12039 | 29493351 |
Epilepsy | 16.54 | 10.57 | 86 | 69051 | 18346 | 29487044 |
Osteonecrosis of jaw | 16.50 | 10.57 | 9 | 69128 | 16501 | 29488889 |
Loose associations | 16.48 | 10.57 | 6 | 69131 | 56 | 29505334 |
Hypersomnia | 16.48 | 10.57 | 59 | 69078 | 10695 | 29494695 |
Nephrolithiasis | 16.46 | 10.57 | 21 | 69116 | 25313 | 29480077 |
Tumour lysis syndrome | 16.33 | 10.57 | 6 | 69131 | 13878 | 29491512 |
Intentional device misuse | 16.33 | 10.57 | 8 | 69129 | 164 | 29505226 |
Urine sodium decreased | 16.24 | 10.57 | 8 | 69129 | 166 | 29505224 |
Cellulitis | 16.17 | 10.57 | 54 | 69083 | 45786 | 29459604 |
Sleep deficit | 16.01 | 10.57 | 11 | 69126 | 433 | 29504957 |
Chest pain | 15.95 | 10.57 | 176 | 68961 | 111797 | 29393593 |
Rapid eye movements sleep abnormal | 15.94 | 10.57 | 8 | 69129 | 173 | 29505217 |
Blood creatinine increased | 15.90 | 10.57 | 125 | 69012 | 84977 | 29420413 |
Hyporesponsive to stimuli | 15.86 | 10.57 | 15 | 69122 | 936 | 29504454 |
Gout | 15.79 | 10.57 | 10 | 69127 | 16901 | 29488489 |
Tricuspid valve sclerosis | 15.65 | 10.57 | 5 | 69132 | 30 | 29505360 |
Ejaculation disorder | 15.64 | 10.57 | 15 | 69122 | 953 | 29504437 |
Hyperkinesia | 15.63 | 10.57 | 19 | 69118 | 1580 | 29503810 |
JC virus CSF test positive | 15.53 | 10.57 | 7 | 69130 | 118 | 29505272 |
Stupor | 15.42 | 10.57 | 25 | 69112 | 2719 | 29502671 |
Speech disorder | 15.42 | 10.57 | 101 | 69036 | 23415 | 29481975 |
Small for dates baby | 15.42 | 10.57 | 29 | 69108 | 3550 | 29501840 |
Loss of proprioception | 15.24 | 10.57 | 10 | 69127 | 364 | 29505026 |
Drug withdrawal syndrome neonatal | 15.24 | 10.57 | 28 | 69109 | 3367 | 29502023 |
Metabolic syndrome | 15.22 | 10.57 | 18 | 69119 | 1455 | 29503935 |
Abdominal discomfort | 15.20 | 10.57 | 59 | 69078 | 47844 | 29457546 |
Oesophageal haemorrhage | 15.19 | 10.57 | 16 | 69121 | 1137 | 29504253 |
Balance disorder | 15.17 | 10.57 | 140 | 68997 | 36030 | 29469360 |
Hyperbilirubinaemia | 15.13 | 10.57 | 8 | 69129 | 14926 | 29490464 |
Acute myeloid leukaemia | 15.10 | 10.57 | 10 | 69127 | 16503 | 29488887 |
Neonatal hyponatraemia | 15.07 | 10.57 | 6 | 69131 | 73 | 29505317 |
Incoherent | 15.02 | 10.57 | 31 | 69106 | 4061 | 29501329 |
Blood ethanol increased | 15.01 | 10.57 | 11 | 69126 | 480 | 29504910 |
Obsessive-compulsive disorder | 14.88 | 10.57 | 33 | 69104 | 4543 | 29500847 |
Palmar-plantar erythrodysaesthesia syndrome | 14.82 | 10.57 | 8 | 69129 | 14751 | 29490639 |
Sinus bradycardia | 14.77 | 10.57 | 60 | 69077 | 11543 | 29493847 |
Dementia | 14.61 | 10.57 | 60 | 69077 | 11598 | 29493792 |
Abnormal weight gain | 14.55 | 10.57 | 14 | 69123 | 893 | 29504497 |
Mumps | 14.51 | 10.57 | 6 | 69131 | 81 | 29505309 |
Self esteem decreased | 14.50 | 10.57 | 11 | 69126 | 506 | 29504884 |
Renal disorder | 14.40 | 10.57 | 19 | 69118 | 22576 | 29482814 |
Lung disorder | 14.31 | 10.57 | 31 | 69106 | 30331 | 29475059 |
Failure to thrive | 14.29 | 10.57 | 45 | 69092 | 7639 | 29497751 |
Pancytopenia | 14.24 | 10.57 | 125 | 69012 | 83043 | 29422347 |
Insulin resistance | 14.19 | 10.57 | 11 | 69126 | 523 | 29504867 |
Neonatal respiratory distress syndrome | 14.14 | 10.57 | 29 | 69108 | 3781 | 29501609 |
Multiple organ dysfunction syndrome | 14.09 | 10.57 | 88 | 69049 | 63028 | 29442362 |
Housebound | 14.07 | 10.57 | 8 | 69129 | 224 | 29505166 |
Thinking abnormal | 14.02 | 10.57 | 35 | 69102 | 5201 | 29500189 |
Major depression | 14.01 | 10.57 | 29 | 69108 | 3806 | 29501584 |
Sinus tachycardia | 14.00 | 10.57 | 71 | 69066 | 14998 | 29490392 |
Arthropathy | 13.87 | 10.57 | 18 | 69119 | 21536 | 29483854 |
Brain oedema | 13.85 | 10.57 | 61 | 69076 | 12159 | 29493231 |
Respiratory tract haemorrhage | 13.83 | 10.57 | 14 | 69123 | 950 | 29504440 |
Xanthoma | 13.82 | 10.57 | 6 | 69131 | 92 | 29505298 |
Sensory disturbance | 13.64 | 10.57 | 36 | 69101 | 5533 | 29499857 |
Splenomegaly | 13.62 | 10.57 | 7 | 69130 | 13272 | 29492118 |
Renal impairment | 13.60 | 10.57 | 123 | 69014 | 81210 | 29424180 |
Hepatic steatosis | 13.59 | 10.57 | 70 | 69067 | 14876 | 29490514 |
Sepsis neonatal | 13.55 | 10.57 | 8 | 69129 | 241 | 29505149 |
Spinal cord injury thoracic | 13.54 | 10.57 | 6 | 69131 | 97 | 29505293 |
Limited symptom panic attack | 13.52 | 10.57 | 5 | 69132 | 49 | 29505341 |
Rebound effect | 13.51 | 10.57 | 20 | 69117 | 2011 | 29503379 |
Stoma site infection | 13.50 | 10.57 | 12 | 69125 | 691 | 29504699 |
Consciousness fluctuating | 13.49 | 10.57 | 14 | 69123 | 978 | 29504412 |
Locked-in syndrome | 13.49 | 10.57 | 8 | 69129 | 243 | 29505147 |
Dyspnoea | 13.39 | 10.57 | 626 | 68511 | 326106 | 29179284 |
Potentiating drug interaction | 13.31 | 10.57 | 31 | 69106 | 4407 | 29500983 |
Abnormal dreams | 13.31 | 10.57 | 41 | 69096 | 6879 | 29498511 |
Psychiatric decompensation | 13.31 | 10.57 | 17 | 69120 | 1487 | 29503903 |
Alcohol poisoning | 13.27 | 10.57 | 25 | 69112 | 3064 | 29502326 |
Basal cell carcinoma | 13.23 | 10.57 | 12 | 69125 | 16898 | 29488492 |
Blood pressure increased | 13.05 | 10.57 | 110 | 69027 | 73693 | 29431697 |
Fungal infection | 12.91 | 10.57 | 8 | 69129 | 13677 | 29491713 |
Acute pulmonary oedema | 12.89 | 10.57 | 40 | 69097 | 6739 | 29498651 |
Rash erythematous | 12.88 | 10.57 | 19 | 69118 | 21543 | 29483847 |
Mitral valve sclerosis | 12.85 | 10.57 | 6 | 69131 | 110 | 29505280 |
Drug reaction with eosinophilia and systemic symptoms | 12.85 | 10.57 | 29 | 69108 | 27963 | 29477427 |
Erectile dysfunction | 12.83 | 10.57 | 79 | 69058 | 17930 | 29487460 |
Body temperature abnormal | 12.72 | 10.57 | 10 | 69127 | 485 | 29504905 |
Respiratory rate decreased | 12.72 | 10.57 | 19 | 69118 | 1926 | 29503464 |
Sexual dysfunction | 12.66 | 10.57 | 36 | 69101 | 5778 | 29499612 |
Neoplasm progression | 12.54 | 10.57 | 15 | 69122 | 18597 | 29486793 |
Infant irritability | 12.52 | 10.57 | 4 | 69133 | 24 | 29505366 |
Intentional product misuse | 12.50 | 10.57 | 130 | 69007 | 34531 | 29470859 |
Abulia | 12.44 | 10.57 | 10 | 69127 | 501 | 29504889 |
Electric shock | 12.43 | 10.57 | 6 | 69131 | 119 | 29505271 |
Oedema peripheral | 12.39 | 10.57 | 169 | 68968 | 103388 | 29402002 |
Bacteraemia | 12.28 | 10.57 | 12 | 69125 | 16311 | 29489079 |
Pseudomonas infection | 12.25 | 10.57 | 5 | 69132 | 10847 | 29494543 |
Light chain disease | 12.25 | 10.57 | 6 | 69131 | 123 | 29505267 |
Polypectomy | 12.22 | 10.57 | 10 | 69127 | 514 | 29504876 |
Cerebellar ataxia | 12.19 | 10.57 | 13 | 69124 | 937 | 29504453 |
Hyperthermia | 12.19 | 10.57 | 49 | 69088 | 9381 | 29496009 |
Gallbladder enlargement | 12.18 | 10.57 | 13 | 69124 | 938 | 29504452 |
Non-alcoholic steatohepatitis | 12.18 | 10.57 | 12 | 69125 | 788 | 29504602 |
Pelvic fracture | 12.10 | 10.57 | 20 | 69117 | 2211 | 29503179 |
Jealous delusion | 12.09 | 10.57 | 7 | 69130 | 203 | 29505187 |
Prostate cancer | 12.08 | 10.57 | 26 | 69111 | 25501 | 29479889 |
Suspiciousness | 12.01 | 10.57 | 8 | 69129 | 299 | 29505091 |
Inferior vena caval occlusion | 11.99 | 10.57 | 4 | 69133 | 28 | 29505362 |
Fear | 11.98 | 10.57 | 49 | 69088 | 9455 | 29495935 |
Dysaesthesia | 11.97 | 10.57 | 19 | 69118 | 2031 | 29503359 |
Bronchopulmonary aspergillosis | 11.95 | 10.57 | 7 | 69130 | 12337 | 29493053 |
Bladder dilatation | 11.91 | 10.57 | 15 | 69122 | 1293 | 29504097 |
Nasal congestion | 11.91 | 10.57 | 16 | 69121 | 18863 | 29486527 |
Pneumocystis jirovecii pneumonia | 11.87 | 10.57 | 13 | 69124 | 16766 | 29488624 |
Neuroblastoma | 11.86 | 10.57 | 6 | 69131 | 132 | 29505258 |
Wrong product administered | 11.83 | 10.57 | 30 | 69107 | 4501 | 29500889 |
Ascites | 11.68 | 10.57 | 45 | 69092 | 36574 | 29468816 |
Accidental poisoning | 11.67 | 10.57 | 10 | 69127 | 548 | 29504842 |
Respiratory acidosis | 11.66 | 10.57 | 29 | 69108 | 4299 | 29501091 |
Product dose omission issue | 11.63 | 10.57 | 157 | 68980 | 96226 | 29409164 |
Productive cough | 11.60 | 10.57 | 36 | 69101 | 31223 | 29474167 |
Hypotonia | 11.56 | 10.57 | 39 | 69098 | 6863 | 29498527 |
Feeling abnormal | 11.49 | 10.57 | 185 | 68952 | 54260 | 29451130 |
Formication | 11.47 | 10.57 | 16 | 69121 | 1524 | 29503866 |
Gastrointestinal disorder | 11.42 | 10.57 | 32 | 69105 | 28674 | 29476716 |
Panic disorder | 11.41 | 10.57 | 14 | 69123 | 1176 | 29504214 |
JC polyomavirus test positive | 11.40 | 10.57 | 10 | 69127 | 566 | 29504824 |
Agitated depression | 11.39 | 10.57 | 7 | 69130 | 227 | 29505163 |
Mutism | 11.37 | 10.57 | 11 | 69126 | 706 | 29504684 |
Contraindication to medical treatment | 11.37 | 10.57 | 9 | 69128 | 441 | 29504949 |
Initial insomnia | 11.36 | 10.57 | 22 | 69115 | 2753 | 29502637 |
Pneumonitis | 11.35 | 10.57 | 31 | 69106 | 28013 | 29477377 |
Rash maculo-papular | 11.28 | 10.57 | 25 | 69112 | 24264 | 29481126 |
Nasal discomfort | 11.20 | 10.57 | 14 | 69123 | 1198 | 29504192 |
Hepatic failure | 11.20 | 10.57 | 37 | 69100 | 31475 | 29473915 |
Hypersensitivity | 11.18 | 10.57 | 75 | 69062 | 52828 | 29452562 |
Fluid retention | 11.15 | 10.57 | 24 | 69113 | 23536 | 29481854 |
Pulmonary fibrosis | 11.11 | 10.57 | 12 | 69125 | 15570 | 29489820 |
Suprapubic pain | 11.06 | 10.57 | 8 | 69129 | 342 | 29505048 |
Psychotic symptom | 10.99 | 10.57 | 15 | 69122 | 1399 | 29503991 |
Fear of disease | 10.99 | 10.57 | 7 | 69130 | 242 | 29505148 |
Kidney congestion | 10.94 | 10.57 | 7 | 69130 | 244 | 29505146 |
Dysstasia | 10.91 | 10.57 | 51 | 69086 | 10423 | 29494967 |
Serum serotonin increased | 10.90 | 10.57 | 5 | 69132 | 88 | 29505302 |
Frequent bowel movements | 10.86 | 10.57 | 4 | 69133 | 9235 | 29496155 |
Product use issue | 10.84 | 10.57 | 73 | 69064 | 51371 | 29454019 |
Diabetes insipidus | 10.83 | 10.57 | 20 | 69117 | 2414 | 29502976 |
Shock | 10.81 | 10.57 | 21 | 69116 | 21383 | 29484007 |
Stoma site induration | 10.75 | 10.57 | 4 | 69133 | 40 | 29505350 |
Bronchitis | 10.70 | 10.57 | 47 | 69090 | 36821 | 29468569 |
Drug abuser | 10.69 | 10.57 | 26 | 69111 | 3801 | 29501589 |
Staphylococcal infection | 10.62 | 10.57 | 34 | 69103 | 29206 | 29476184 |
Hypertrophic scar | 10.59 | 10.57 | 3 | 69134 | 11 | 29505379 |
Tachypnoea | 10.58 | 10.57 | 66 | 69071 | 15049 | 29490341 |
Localised infection | 10.58 | 10.57 | 10 | 69127 | 13806 | 29491584 |
Bronchial aspiration procedure | 10.57 | 10.57 | 4 | 69133 | 42 | 29505348 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Toxicity to various agents | 870.98 | 9.95 | 2262 | 142188 | 361251 | 63993031 |
Intentional overdose | 728.38 | 9.95 | 951 | 143499 | 88993 | 64265289 |
Serotonin syndrome | 685.49 | 9.95 | 623 | 143827 | 38659 | 64315623 |
Suicide attempt | 674.05 | 9.95 | 813 | 143637 | 70194 | 64284088 |
Completed suicide | 626.52 | 9.95 | 1482 | 142968 | 222932 | 64131350 |
Intentional self-injury | 612.18 | 9.95 | 513 | 143937 | 28531 | 64325751 |
Drug abuse | 532.44 | 9.95 | 1015 | 143435 | 131359 | 64222923 |
Suicidal ideation | 531.40 | 9.95 | 699 | 143751 | 65843 | 64288439 |
Sopor | 516.60 | 9.95 | 470 | 143980 | 29191 | 64325091 |
Overdose | 447.23 | 9.95 | 1056 | 143394 | 158510 | 64195772 |
Agitation | 426.97 | 9.95 | 734 | 143716 | 87633 | 64266649 |
Somnolence | 415.01 | 9.95 | 1196 | 143254 | 202449 | 64151833 |
Drug interaction | 360.92 | 9.95 | 1685 | 142765 | 360398 | 63993884 |
Electrocardiogram QT prolonged | 351.52 | 9.95 | 635 | 143815 | 78813 | 64275469 |
Confusional state | 334.72 | 9.95 | 1312 | 143138 | 259832 | 64094450 |
Restlessness | 273.72 | 9.95 | 389 | 144061 | 39396 | 64314886 |
Coma | 269.64 | 9.95 | 602 | 143848 | 87013 | 64267269 |
Hyponatraemia | 262.14 | 9.95 | 829 | 143621 | 147510 | 64206772 |
Fall | 228.56 | 9.95 | 1656 | 142794 | 415170 | 63939112 |
Neuroleptic malignant syndrome | 228.51 | 9.95 | 281 | 144169 | 24715 | 64329567 |
Disorientation | 225.26 | 9.95 | 429 | 144021 | 55399 | 64298883 |
Tremor | 218.98 | 9.95 | 780 | 143670 | 147450 | 64206832 |
Restless legs syndrome | 218.78 | 9.95 | 229 | 144221 | 16887 | 64337395 |
Inappropriate antidiuretic hormone secretion | 196.41 | 9.95 | 246 | 144204 | 22043 | 64332239 |
Nightmare | 191.89 | 9.95 | 236 | 144214 | 20757 | 64333525 |
Delirium | 186.06 | 9.95 | 451 | 143999 | 68743 | 64285539 |
Depressed level of consciousness | 185.97 | 9.95 | 499 | 143951 | 80937 | 64273345 |
Muscle rigidity | 185.44 | 9.95 | 212 | 144238 | 17261 | 64337021 |
Anxiety | 184.69 | 9.95 | 920 | 143530 | 201729 | 64152553 |
Rheumatoid arthritis | 183.76 | 9.95 | 69 | 144381 | 164225 | 64190057 |
Infusion related reaction | 179.11 | 9.95 | 72 | 144378 | 164395 | 64189887 |
Disturbance in attention | 177.38 | 9.95 | 325 | 144125 | 40749 | 64313533 |
Aggression | 173.98 | 9.95 | 345 | 144105 | 45887 | 64308395 |
Synovitis | 166.65 | 9.95 | 15 | 144435 | 99075 | 64255207 |
Joint swelling | 165.90 | 9.95 | 143 | 144307 | 215239 | 64139043 |
Tachycardia | 158.05 | 9.95 | 709 | 143741 | 148870 | 64205412 |
Depressed mood | 157.89 | 9.95 | 309 | 144141 | 40703 | 64313579 |
Drug withdrawal syndrome | 157.69 | 9.95 | 265 | 144185 | 31026 | 64323256 |
Akathisia | 154.31 | 9.95 | 158 | 144292 | 11352 | 64342930 |
Dyskinesia | 151.92 | 9.95 | 297 | 144153 | 39091 | 64315191 |
Hallucination, visual | 151.42 | 9.95 | 244 | 144206 | 27590 | 64326692 |
Nasopharyngitis | 148.79 | 9.95 | 132 | 144318 | 195941 | 64158341 |
Rash | 148.57 | 9.95 | 528 | 143922 | 458021 | 63896261 |
Mania | 147.10 | 9.95 | 182 | 144268 | 16104 | 64338178 |
Extrapyramidal disorder | 143.13 | 9.95 | 197 | 144253 | 19355 | 64334927 |
Depersonalisation/derealisation disorder | 142.97 | 9.95 | 71 | 144379 | 1569 | 64352713 |
Arthropathy | 140.02 | 9.95 | 48 | 144402 | 120919 | 64233363 |
Dissociation | 139.70 | 9.95 | 86 | 144364 | 2925 | 64351357 |
Accidental overdose | 135.49 | 9.95 | 258 | 144192 | 33299 | 64320983 |
Sinusitis | 131.65 | 9.95 | 82 | 144368 | 145846 | 64208436 |
Withdrawal syndrome | 130.61 | 9.95 | 208 | 144242 | 23284 | 64330998 |
Arthralgia | 127.92 | 9.95 | 533 | 143917 | 441727 | 63912555 |
Psychotic disorder | 126.45 | 9.95 | 255 | 144195 | 34323 | 64319959 |
Systemic lupus erythematosus | 124.64 | 9.95 | 14 | 144436 | 77598 | 64276684 |
Parkinsonism | 124.03 | 9.95 | 157 | 144293 | 14216 | 64340066 |
Drug ineffective | 121.43 | 9.95 | 1251 | 143199 | 838996 | 63515286 |
Drug hypersensitivity | 119.32 | 9.95 | 219 | 144231 | 237596 | 64116686 |
Sedation | 118.72 | 9.95 | 277 | 144173 | 41185 | 64313097 |
Urinary retention | 116.87 | 9.95 | 306 | 144144 | 48895 | 64305387 |
Swelling | 116.63 | 9.95 | 112 | 144338 | 160106 | 64194176 |
Derealisation | 116.52 | 9.95 | 60 | 144390 | 1435 | 64352847 |
Cogwheel rigidity | 116.12 | 9.95 | 75 | 144375 | 2778 | 64351504 |
Hallucination | 115.15 | 9.95 | 392 | 144058 | 72396 | 64281886 |
Myoclonus | 111.29 | 9.95 | 201 | 144249 | 24917 | 64329365 |
Peripheral swelling | 110.90 | 9.95 | 186 | 144264 | 208967 | 64145315 |
General physical health deterioration | 110.40 | 9.95 | 810 | 143640 | 203615 | 64150667 |
Pemphigus | 108.24 | 9.95 | 7 | 144443 | 60694 | 64293588 |
Alopecia | 108.11 | 9.95 | 127 | 144323 | 165563 | 64188719 |
Dystonia | 107.59 | 9.95 | 169 | 144281 | 18696 | 64335586 |
Gastric pH decreased | 102.23 | 9.95 | 44 | 144406 | 691 | 64353591 |
Dysarthria | 102.05 | 9.95 | 329 | 144121 | 59077 | 64295205 |
Poisoning | 101.97 | 9.95 | 179 | 144271 | 21700 | 64332582 |
Mydriasis | 99.84 | 9.95 | 146 | 144304 | 15166 | 64339116 |
Treatment failure | 99.46 | 9.95 | 70 | 144380 | 116746 | 64237536 |
Feeling of despair | 98.39 | 9.95 | 65 | 144385 | 2503 | 64351779 |
Loss of consciousness | 98.04 | 9.95 | 618 | 143832 | 147747 | 64206535 |
Hyperhidrosis | 96.43 | 9.95 | 542 | 143908 | 124378 | 64229904 |
Psychomotor hyperactivity | 95.99 | 9.95 | 139 | 144311 | 14312 | 64339970 |
Injection site pain | 95.86 | 9.95 | 66 | 144384 | 111342 | 64242940 |
Hallucination, auditory | 95.57 | 9.95 | 151 | 144299 | 16788 | 64337494 |
Abdominal discomfort | 94.02 | 9.95 | 165 | 144285 | 182157 | 64172125 |
Glossodynia | 93.70 | 9.95 | 16 | 144434 | 64680 | 64289602 |
Intrusive thoughts | 93.39 | 9.95 | 34 | 144416 | 333 | 64353949 |
Urticaria | 92.83 | 9.95 | 116 | 144334 | 147201 | 64207081 |
Pain | 91.27 | 9.95 | 797 | 143653 | 552714 | 63801568 |
Cough | 91.11 | 9.95 | 358 | 144092 | 301790 | 64052492 |
Therapeutic product effect decreased | 89.46 | 9.95 | 76 | 144374 | 115275 | 64239007 |
Drug intolerance | 88.27 | 9.95 | 180 | 144270 | 187812 | 64166470 |
Mood swings | 86.76 | 9.95 | 147 | 144303 | 17321 | 64336961 |
Abnormal behaviour | 85.94 | 9.95 | 215 | 144235 | 33407 | 64320875 |
Seizure | 84.26 | 9.95 | 651 | 143799 | 166241 | 64188041 |
Contraindicated product administered | 82.46 | 9.95 | 72 | 144378 | 107757 | 64246525 |
Depression | 82.26 | 9.95 | 696 | 143754 | 182595 | 64171687 |
Feeling jittery | 82.15 | 9.95 | 110 | 144340 | 10525 | 64343757 |
Febrile neutropenia | 82.03 | 9.95 | 187 | 144263 | 187470 | 64166812 |
Drug dependence | 82.00 | 9.95 | 210 | 144240 | 33102 | 64321180 |
Tardive dyskinesia | 80.37 | 9.95 | 101 | 144349 | 9077 | 64345205 |
Hypersensitivity | 78.60 | 9.95 | 205 | 144245 | 196247 | 64158035 |
Delusion | 78.33 | 9.95 | 143 | 144307 | 17871 | 64336411 |
Pruritus | 78.01 | 9.95 | 397 | 144053 | 312003 | 64042279 |
Pleurothotonus | 78.01 | 9.95 | 54 | 144396 | 2248 | 64352034 |
Hypertonia | 77.93 | 9.95 | 83 | 144367 | 6242 | 64348040 |
Pneumonia aspiration | 77.45 | 9.95 | 300 | 144150 | 58971 | 64295311 |
Paranoia | 76.48 | 9.95 | 134 | 144316 | 16218 | 64338064 |
Logorrhoea | 75.93 | 9.95 | 67 | 144383 | 3992 | 64350290 |
Depressive symptom | 75.81 | 9.95 | 70 | 144380 | 4426 | 64349856 |
Off label use | 74.89 | 9.95 | 984 | 143466 | 631822 | 63722460 |
Sleep disorder | 74.61 | 9.95 | 298 | 144152 | 59411 | 64294871 |
Poisoning deliberate | 74.59 | 9.95 | 119 | 144331 | 13339 | 64340943 |
Altered state of consciousness | 72.56 | 9.95 | 218 | 144232 | 37684 | 64316598 |
Anger | 69.77 | 9.95 | 126 | 144324 | 15615 | 64338667 |
Hallucinations, mixed | 68.60 | 9.95 | 76 | 144374 | 5976 | 64348306 |
Rhabdomyolysis | 66.85 | 9.95 | 392 | 144058 | 91334 | 64262948 |
Product prescribing error | 66.71 | 9.95 | 202 | 144248 | 35067 | 64319215 |
Asphyxia | 66.45 | 9.95 | 94 | 144356 | 9472 | 64344810 |
Respiratory arrest | 65.85 | 9.95 | 264 | 144186 | 52721 | 64301561 |
Panic attack | 65.54 | 9.95 | 145 | 144305 | 20808 | 64333474 |
Arthritis | 65.25 | 9.95 | 55 | 144395 | 83759 | 64270523 |
Myocardial infarction | 64.83 | 9.95 | 175 | 144275 | 165646 | 64188636 |
Bradyphrenia | 64.71 | 9.95 | 92 | 144358 | 9314 | 64344968 |
Pericarditis | 63.84 | 9.95 | 30 | 144420 | 62486 | 64291796 |
Incontinence | 63.11 | 9.95 | 104 | 144346 | 11977 | 64342305 |
Abnormal dreams | 60.76 | 9.95 | 94 | 144356 | 10262 | 64344020 |
On and off phenomenon | 60.42 | 9.95 | 48 | 144402 | 2471 | 64351811 |
Impaired healing | 60.25 | 9.95 | 30 | 144420 | 60443 | 64293839 |
Product use issue | 60.15 | 9.95 | 159 | 144291 | 151556 | 64202726 |
Irritability | 59.94 | 9.95 | 200 | 144250 | 36546 | 64317736 |
Injection site erythema | 59.50 | 9.95 | 43 | 144407 | 70757 | 64283525 |
Homicidal ideation | 59.41 | 9.95 | 53 | 144397 | 3204 | 64351078 |
Wrong patient received product | 58.50 | 9.95 | 56 | 144394 | 3706 | 64350576 |
Injection site pruritus | 57.86 | 9.95 | 8 | 144442 | 37818 | 64316464 |
Insomnia | 57.60 | 9.95 | 687 | 143763 | 197149 | 64157133 |
Nasal congestion | 57.36 | 9.95 | 31 | 144419 | 59627 | 64294655 |
Miosis | 57.29 | 9.95 | 105 | 144345 | 13161 | 64341121 |
Illusion | 55.97 | 9.95 | 38 | 144412 | 1532 | 64352750 |
Interstitial lung disease | 55.46 | 9.95 | 83 | 144367 | 97649 | 64256633 |
Apathy | 55.09 | 9.95 | 94 | 144356 | 11138 | 64343144 |
Folliculitis | 55.04 | 9.95 | 3 | 144447 | 30074 | 64324208 |
Platelet count decreased | 54.88 | 9.95 | 192 | 144258 | 167519 | 64186763 |
Erythema | 54.21 | 9.95 | 225 | 144225 | 186845 | 64167437 |
Schizophrenia | 54.16 | 9.95 | 93 | 144357 | 11075 | 64343207 |
Bradykinesia | 53.99 | 9.95 | 70 | 144380 | 6490 | 64347792 |
H1N1 influenza | 53.97 | 9.95 | 43 | 144407 | 2223 | 64352059 |
Psychomotor retardation | 53.89 | 9.95 | 62 | 144388 | 5081 | 64349201 |
Drooling | 53.85 | 9.95 | 63 | 144387 | 5256 | 64349026 |
Respiratory depression | 53.82 | 9.95 | 144 | 144306 | 23299 | 64330983 |
Persecutory delusion | 53.79 | 9.95 | 56 | 144394 | 4102 | 64350180 |
Feeling of body temperature change | 53.78 | 9.95 | 60 | 144390 | 4754 | 64349528 |
Speech disorder | 52.88 | 9.95 | 232 | 144218 | 48209 | 64306073 |
Product administration error | 51.98 | 9.95 | 158 | 144292 | 27485 | 64326797 |
Antidepressant drug level above therapeutic | 51.41 | 9.95 | 25 | 144425 | 527 | 64353755 |
Parosmia | 50.42 | 9.95 | 57 | 144393 | 4583 | 64349699 |
Herpes zoster | 50.23 | 9.95 | 62 | 144388 | 79125 | 64275157 |
Major depression | 50.19 | 9.95 | 74 | 144376 | 7742 | 64346540 |
Pain in extremity | 49.99 | 9.95 | 436 | 144014 | 302649 | 64051633 |
Substance abuse | 49.90 | 9.95 | 81 | 144369 | 9211 | 64345071 |
Loss of libido | 49.67 | 9.95 | 42 | 144408 | 2362 | 64351920 |
Pneumonia | 49.24 | 9.95 | 920 | 143530 | 558656 | 63795626 |
Cardiac failure congestive | 48.66 | 9.95 | 141 | 144309 | 130439 | 64223843 |
Back pain | 48.64 | 9.95 | 344 | 144106 | 249827 | 64104455 |
Urinary hesitation | 48.53 | 9.95 | 49 | 144401 | 3461 | 64350821 |
Intentional product use issue | 48.50 | 9.95 | 87 | 144363 | 95277 | 64259005 |
Infection | 47.78 | 9.95 | 232 | 144218 | 184648 | 64169634 |
Intestinal pseudo-obstruction | 47.73 | 9.95 | 38 | 144412 | 1962 | 64352320 |
Tachyphrenia | 47.70 | 9.95 | 37 | 144413 | 1839 | 64352443 |
Asthma | 47.42 | 9.95 | 88 | 144362 | 95137 | 64259145 |
Helplessness | 46.94 | 9.95 | 20 | 144430 | 306 | 64353976 |
Systemic infection | 46.81 | 9.95 | 53 | 144397 | 4268 | 64350014 |
Stomatitis | 46.44 | 9.95 | 111 | 144339 | 109494 | 64244788 |
Neuropathy peripheral | 45.94 | 9.95 | 124 | 144326 | 117401 | 64236881 |
Acute psychosis | 45.81 | 9.95 | 49 | 144401 | 3703 | 64350579 |
Epilepsy | 45.67 | 9.95 | 172 | 144278 | 33359 | 64320923 |
Aptyalism | 45.17 | 9.95 | 25 | 144425 | 694 | 64353588 |
Duodenal ulcer perforation | 45.08 | 9.95 | 11 | 144439 | 34614 | 64319668 |
Cardiac arrest | 44.82 | 9.95 | 535 | 143915 | 153529 | 64200753 |
Injection site bruising | 44.62 | 9.95 | 13 | 144437 | 36360 | 64317922 |
Psoriatic arthropathy | 43.83 | 9.95 | 21 | 144429 | 43260 | 64311022 |
Fatigue | 43.40 | 9.95 | 1312 | 143138 | 747418 | 63606864 |
Mental disorder | 43.19 | 9.95 | 144 | 144306 | 26301 | 64327981 |
Irritable bowel syndrome | 42.92 | 9.95 | 15 | 144435 | 37354 | 64316928 |
Gastrointestinal disorder | 42.84 | 9.95 | 85 | 144365 | 89624 | 64264658 |
Galactorrhoea | 42.80 | 9.95 | 44 | 144406 | 3175 | 64351107 |
Discomfort | 42.75 | 9.95 | 72 | 144378 | 80806 | 64273476 |
Cytomegalovirus infection | 42.61 | 9.95 | 15 | 144435 | 37184 | 64317098 |
Hyperkinesia | 41.69 | 9.95 | 39 | 144411 | 2507 | 64351775 |
Hepatic enzyme increased | 41.67 | 9.95 | 150 | 144300 | 129793 | 64224489 |
Antipsychotic drug level above therapeutic | 41.54 | 9.95 | 34 | 144416 | 1827 | 64352455 |
Diarrhoea | 41.23 | 9.95 | 1269 | 143181 | 721435 | 63632847 |
Menstrual disorder | 41.18 | 9.95 | 44 | 144406 | 3321 | 64350961 |
Knee arthroplasty | 40.62 | 9.95 | 6 | 144444 | 26993 | 64327289 |
Injection site swelling | 40.47 | 9.95 | 21 | 144429 | 41332 | 64312950 |
Abulia | 40.20 | 9.95 | 25 | 144425 | 866 | 64353416 |
Priapism | 40.16 | 9.95 | 47 | 144403 | 3923 | 64350359 |
Pyrexia | 39.05 | 9.95 | 953 | 143497 | 557691 | 63796591 |
Intentional product misuse | 38.68 | 9.95 | 286 | 144164 | 72009 | 64282273 |
Bronchitis | 38.66 | 9.95 | 120 | 144330 | 108623 | 64245659 |
Thrombocytopenia | 38.65 | 9.95 | 318 | 144132 | 223483 | 64130799 |
Unresponsive to stimuli | 38.42 | 9.95 | 218 | 144232 | 50175 | 64304107 |
Maternal exposure during pregnancy | 38.36 | 9.95 | 100 | 144350 | 95784 | 64258498 |
Incoherent | 38.16 | 9.95 | 62 | 144388 | 7056 | 64347226 |
Blister | 37.57 | 9.95 | 78 | 144372 | 80889 | 64273393 |
Product dose omission issue | 37.25 | 9.95 | 269 | 144181 | 194478 | 64159804 |
Circulatory collapse | 37.16 | 9.95 | 162 | 144288 | 33570 | 64320712 |
Myelosuppression | 36.54 | 9.95 | 5 | 144445 | 23825 | 64330457 |
Abnormal weight gain | 36.43 | 9.95 | 34 | 144416 | 2179 | 64352103 |
Device expulsion | 36.07 | 9.95 | 3 | 144447 | 21133 | 64333149 |
Accidental death | 35.86 | 9.95 | 43 | 144407 | 3682 | 64350600 |
Polydipsia | 35.79 | 9.95 | 54 | 144396 | 5767 | 64348515 |
Osteoarthritis | 35.72 | 9.95 | 54 | 144396 | 63282 | 64291000 |
Fungal infection | 35.64 | 9.95 | 16 | 144434 | 34235 | 64320047 |
Upper respiratory tract infection | 35.59 | 9.95 | 68 | 144382 | 72717 | 64281565 |
Fracture | 35.07 | 9.95 | 107 | 144343 | 18648 | 64335634 |
Therapeutic product ineffective | 34.52 | 9.95 | 28 | 144422 | 1485 | 64352797 |
Septic shock | 34.28 | 9.95 | 121 | 144329 | 105316 | 64248966 |
Suspected suicide | 34.26 | 9.95 | 66 | 144384 | 8588 | 64345694 |
Hyponatraemic coma | 33.77 | 9.95 | 9 | 144441 | 26 | 64354256 |
Activation syndrome | 33.72 | 9.95 | 15 | 144435 | 256 | 64354026 |
Acute motor-sensory axonal neuropathy | 33.46 | 9.95 | 17 | 144433 | 395 | 64353887 |
Anaphylactic shock | 33.44 | 9.95 | 13 | 144437 | 30315 | 64323967 |
Muscle disorder | 33.43 | 9.95 | 48 | 144402 | 4903 | 64349379 |
Gestational diabetes | 33.16 | 9.95 | 51 | 144399 | 5539 | 64348743 |
Product monitoring error | 32.69 | 9.95 | 50 | 144400 | 5404 | 64348878 |
Hyperreflexia | 32.68 | 9.95 | 58 | 144392 | 7090 | 64347192 |
Lower respiratory tract infection | 32.51 | 9.95 | 106 | 144344 | 94508 | 64259774 |
Catatonia | 32.51 | 9.95 | 60 | 144390 | 7560 | 64346722 |
Progressive multifocal leukoencephalopathy | 32.23 | 9.95 | 102 | 144348 | 18130 | 64336152 |
Blood pressure increased | 32.20 | 9.95 | 240 | 144210 | 172312 | 64181970 |
Social avoidant behaviour | 31.98 | 9.95 | 45 | 144405 | 4512 | 64349770 |
Cognitive disorder | 31.83 | 9.95 | 222 | 144228 | 54865 | 64299417 |
Illness anxiety disorder | 31.74 | 9.95 | 14 | 144436 | 234 | 64354048 |
Muscle injury | 31.43 | 9.95 | 10 | 144440 | 26427 | 64327855 |
Sleep paralysis | 31.27 | 9.95 | 18 | 144432 | 540 | 64353742 |
Chest pain | 31.16 | 9.95 | 358 | 144092 | 235622 | 64118660 |
Impulsive behaviour | 31.15 | 9.95 | 34 | 144416 | 2629 | 64351653 |
Feelings of worthlessness | 30.81 | 9.95 | 17 | 144433 | 469 | 64353813 |
Cataract | 30.59 | 9.95 | 42 | 144408 | 51220 | 64303062 |
Decreased gait velocity | 30.21 | 9.95 | 12 | 144438 | 152 | 64354130 |
Headache | 30.05 | 9.95 | 930 | 143520 | 528537 | 63825745 |
Hypomania | 29.97 | 9.95 | 49 | 144401 | 5605 | 64348677 |
Analgesic drug level above therapeutic | 29.79 | 9.95 | 16 | 144434 | 418 | 64353864 |
Muscle twitching | 29.74 | 9.95 | 102 | 144348 | 18896 | 64335386 |
Pallor | 29.71 | 9.95 | 168 | 144282 | 38613 | 64315669 |
Hypoaesthesia oral | 29.53 | 9.95 | 74 | 144376 | 11506 | 64342776 |
Feeling guilty | 29.53 | 9.95 | 20 | 144430 | 803 | 64353479 |
Dysphagia | 29.35 | 9.95 | 367 | 144083 | 106445 | 64247837 |
Hyperthermia | 29.34 | 9.95 | 89 | 144361 | 15461 | 64338821 |
Coma scale abnormal | 29.21 | 9.95 | 58 | 144392 | 7716 | 64346566 |
COVID-19 | 29.18 | 9.95 | 64 | 144386 | 65076 | 64289206 |
Sarcopenia | 29.00 | 9.95 | 15 | 144435 | 362 | 64353920 |
Parkinsonian gait | 28.97 | 9.95 | 20 | 144430 | 829 | 64353453 |
Hypotonia | 28.96 | 9.95 | 72 | 144378 | 11140 | 64343142 |
Syncope | 28.90 | 9.95 | 505 | 143945 | 157130 | 64197152 |
Language disorder | 28.88 | 9.95 | 33 | 144417 | 2684 | 64351598 |
Blood creatine phosphokinase increased | 28.72 | 9.95 | 227 | 144223 | 58331 | 64295951 |
Sepsis | 28.66 | 9.95 | 354 | 144096 | 229987 | 64124295 |
Bipolar disorder | 28.55 | 9.95 | 53 | 144397 | 6708 | 64347574 |
Mental impairment | 28.49 | 9.95 | 91 | 144359 | 16252 | 64338030 |
Productive cough | 28.03 | 9.95 | 78 | 144372 | 73125 | 64281157 |
Platypnoea | 28.03 | 9.95 | 8 | 144442 | 32 | 64354250 |
Nephrolithiasis | 27.91 | 9.95 | 34 | 144416 | 43649 | 64310633 |
Disease progression | 27.91 | 9.95 | 194 | 144256 | 141486 | 64212796 |
Bradypnoea | 27.74 | 9.95 | 45 | 144405 | 5114 | 64349168 |
Osteoporosis | 27.69 | 9.95 | 32 | 144418 | 42048 | 64312234 |
Rhinorrhoea | 27.62 | 9.95 | 58 | 144392 | 59911 | 64294371 |
Pleural effusion | 27.62 | 9.95 | 168 | 144282 | 126391 | 64227891 |
Mucosal inflammation | 27.61 | 9.95 | 62 | 144388 | 62522 | 64291760 |
Posture abnormal | 27.49 | 9.95 | 36 | 144414 | 3370 | 64350912 |
Mutism | 27.40 | 9.95 | 28 | 144422 | 2006 | 64352276 |
Serum serotonin increased | 27.13 | 9.95 | 13 | 144437 | 265 | 64354017 |
Acute myeloid leukaemia | 26.79 | 9.95 | 14 | 144436 | 27449 | 64326833 |
Thrombotic microangiopathy | 26.74 | 9.95 | 3 | 144447 | 16652 | 64337630 |
Ejaculation failure | 26.73 | 9.95 | 14 | 144436 | 347 | 64353935 |
Blood prolactin increased | 26.50 | 9.95 | 36 | 144414 | 3492 | 64350790 |
Psoriasis | 26.28 | 9.95 | 78 | 144372 | 71625 | 64282657 |
Generalised tonic-clonic seizure | 26.27 | 9.95 | 166 | 144284 | 39691 | 64314591 |
Palmar-plantar erythrodysaesthesia syndrome | 26.24 | 9.95 | 16 | 144434 | 28803 | 64325479 |
Malignant neoplasm progression | 26.13 | 9.95 | 147 | 144303 | 112724 | 64241558 |
Dyspnoea | 26.09 | 9.95 | 1330 | 143120 | 717344 | 63636938 |
Pressure of speech | 26.01 | 9.95 | 20 | 144430 | 981 | 64353301 |
Multiple organ dysfunction syndrome | 25.75 | 9.95 | 128 | 144322 | 101285 | 64252997 |
Basal cell carcinoma | 25.55 | 9.95 | 19 | 144431 | 30819 | 64323463 |
Urogenital haemorrhage | 25.54 | 9.95 | 17 | 144433 | 663 | 64353619 |
Thinking abnormal | 25.54 | 9.95 | 70 | 144380 | 11486 | 64342796 |
Fluid retention | 25.53 | 9.95 | 60 | 144390 | 59546 | 64294736 |
Electrocardiogram abnormal | 25.29 | 9.95 | 77 | 144373 | 13404 | 64340878 |
Medication error | 25.22 | 9.95 | 195 | 144255 | 49771 | 64304511 |
Crush syndrome | 25.20 | 9.95 | 11 | 144439 | 179 | 64354103 |
Rash erythematous | 25.05 | 9.95 | 44 | 144406 | 48589 | 64305693 |
Ataxia | 25.04 | 9.95 | 107 | 144343 | 21977 | 64332305 |
Sudden death | 24.85 | 9.95 | 100 | 144350 | 19996 | 64334286 |
Formication | 24.80 | 9.95 | 39 | 144411 | 4318 | 64349964 |
Psychiatric decompensation | 24.65 | 9.95 | 29 | 144421 | 2434 | 64351848 |
Erectile dysfunction | 24.51 | 9.95 | 73 | 144377 | 12554 | 64341728 |
Ill-defined disorder | 24.42 | 9.95 | 38 | 144412 | 44014 | 64310268 |
Macrophages increased | 24.40 | 9.95 | 11 | 144439 | 194 | 64354088 |
Alcoholism | 24.36 | 9.95 | 34 | 144416 | 3383 | 64350899 |
Benign gastrointestinal neoplasm | 24.34 | 9.95 | 10 | 144440 | 139 | 64354143 |
Tonic clonic movements | 24.33 | 9.95 | 26 | 144424 | 1963 | 64352319 |
Pyroglutamic acidosis | 24.32 | 9.95 | 17 | 144433 | 719 | 64353563 |
Injection site haemorrhage | 24.25 | 9.95 | 12 | 144438 | 24266 | 64330016 |
Stoma site discharge | 24.21 | 9.95 | 24 | 144426 | 1658 | 64352624 |
Suicidal behaviour | 24.06 | 9.95 | 31 | 144419 | 2856 | 64351426 |
Bursitis | 24.04 | 9.95 | 9 | 144441 | 21476 | 64332806 |
Antipsychotic drug level increased | 24.03 | 9.95 | 42 | 144408 | 5073 | 64349209 |
Akinesia | 24.01 | 9.95 | 32 | 144418 | 3047 | 64351235 |
Blood pressure diastolic decreased | 23.87 | 9.95 | 10 | 144440 | 22291 | 64331991 |
Stupor | 23.86 | 9.95 | 46 | 144404 | 5989 | 64348293 |
Hip arthroplasty | 23.79 | 9.95 | 9 | 144441 | 21342 | 64332940 |
Balance disorder | 23.76 | 9.95 | 290 | 144160 | 83636 | 64270646 |
Transplant rejection | 23.71 | 9.95 | 5 | 144445 | 17396 | 64336886 |
Chemical burn of oral cavity | 23.40 | 9.95 | 8 | 144442 | 64 | 64354218 |
Premature labour | 23.01 | 9.95 | 52 | 144398 | 7568 | 64346714 |
Increased appetite | 22.96 | 9.95 | 62 | 144388 | 10084 | 64344198 |
Phagophobia | 22.94 | 9.95 | 7 | 144443 | 37 | 64354245 |
Panic reaction | 22.85 | 9.95 | 36 | 144414 | 3991 | 64350291 |
Oesophageal obstruction | 22.69 | 9.95 | 17 | 144433 | 802 | 64353480 |
Mood altered | 22.62 | 9.95 | 83 | 144367 | 15896 | 64338386 |
Norepinephrine increased | 22.57 | 9.95 | 8 | 144442 | 72 | 64354210 |
Rhonchi | 22.55 | 9.95 | 33 | 144417 | 3430 | 64350852 |
Chorea | 22.47 | 9.95 | 25 | 144425 | 1975 | 64352307 |
IVth nerve disorder | 22.35 | 9.95 | 6 | 144444 | 18 | 64354264 |
Cellulitis | 22.21 | 9.95 | 121 | 144329 | 93536 | 64260746 |
Histrionic personality disorder | 22.20 | 9.95 | 7 | 144443 | 42 | 64354240 |
Product prescribing issue | 22.17 | 9.95 | 26 | 144424 | 2175 | 64352107 |
Agranulocytosis | 22.04 | 9.95 | 154 | 144296 | 38075 | 64316207 |
Inappropriate schedule of product administration | 22.01 | 9.95 | 119 | 144331 | 92167 | 64262115 |
Atrial fibrillation | 22.01 | 9.95 | 261 | 144189 | 170828 | 64183454 |
Tumour lysis syndrome | 21.99 | 9.95 | 8 | 144442 | 19432 | 64334850 |
Potentiating drug interaction | 21.97 | 9.95 | 52 | 144398 | 7800 | 64346482 |
Alcohol use | 21.89 | 9.95 | 38 | 144412 | 4564 | 64349718 |
Sensory loss | 21.88 | 9.95 | 61 | 144389 | 10108 | 64344174 |
Inflammation | 21.85 | 9.95 | 74 | 144376 | 65226 | 64289056 |
Cardio-respiratory arrest | 21.68 | 9.95 | 325 | 144125 | 98068 | 64256214 |
Heart rate decreased | 21.59 | 9.95 | 58 | 144392 | 55009 | 64299273 |
Somnambulism | 21.33 | 9.95 | 40 | 144410 | 5101 | 64349181 |
Hallucination, synaesthetic | 21.28 | 9.95 | 7 | 144443 | 49 | 64354233 |
Glassy eyes | 21.22 | 9.95 | 9 | 144441 | 136 | 64354146 |
Hyporesponsive to stimuli | 21.12 | 9.95 | 23 | 144427 | 1774 | 64352508 |
Opisthotonus | 21.02 | 9.95 | 15 | 144435 | 656 | 64353626 |
Blood pressure systolic increased | 21.00 | 9.95 | 50 | 144400 | 49403 | 64304879 |
Influenza | 20.91 | 9.95 | 146 | 144304 | 106385 | 64247897 |
Gait disturbance | 20.87 | 9.95 | 519 | 143931 | 171636 | 64182646 |
Anaemia | 20.75 | 9.95 | 668 | 143782 | 378012 | 63976270 |
Acute myocardial infarction | 20.71 | 9.95 | 83 | 144367 | 69635 | 64284647 |
Merycism | 20.60 | 9.95 | 10 | 144440 | 210 | 64354072 |
Gastrooesophageal reflux disease | 20.51 | 9.95 | 106 | 144344 | 83037 | 64271245 |
Stoma site infection | 20.38 | 9.95 | 19 | 144431 | 1216 | 64353066 |
Myelodysplastic syndrome | 20.37 | 9.95 | 19 | 144431 | 27560 | 64326722 |
Thymus disorder | 20.22 | 9.95 | 10 | 144440 | 219 | 64354063 |
Hanging | 20.16 | 9.95 | 8 | 144442 | 101 | 64354181 |
Congenital cerebrovascular anomaly | 20.05 | 9.95 | 5 | 144445 | 10 | 64354272 |
Pulmonary congestion | 20.01 | 9.95 | 106 | 144344 | 23774 | 64330508 |
Sinus tachycardia | 19.95 | 9.95 | 132 | 144318 | 32056 | 64322226 |
Euphoric mood | 19.92 | 9.95 | 45 | 144405 | 6546 | 64347736 |
Oropharyngeal pain | 19.89 | 9.95 | 117 | 144333 | 88750 | 64265532 |
Ejaculation disorder | 19.81 | 9.95 | 13 | 144437 | 495 | 64353787 |
Vestibular disorder | 19.71 | 9.95 | 25 | 144425 | 2268 | 64352014 |
Bulimia nervosa | 19.69 | 9.95 | 10 | 144440 | 232 | 64354050 |
Faecaloma | 19.61 | 9.95 | 57 | 144393 | 9671 | 64344611 |
Obsessive-compulsive disorder | 19.39 | 9.95 | 37 | 144413 | 4781 | 64349501 |
Breast discomfort | 19.35 | 9.95 | 11 | 144439 | 322 | 64353960 |
Aspiration | 19.29 | 9.95 | 82 | 144368 | 16803 | 64337479 |
Osteomyelitis | 19.23 | 9.95 | 20 | 144430 | 27567 | 64326715 |
Alcohol interaction | 19.21 | 9.95 | 35 | 144415 | 4366 | 64349916 |
Injection site reaction | 19.17 | 9.95 | 48 | 144402 | 46616 | 64307666 |
Pseudomonas infection | 19.17 | 9.95 | 8 | 144442 | 17875 | 64336407 |
Hypophagia | 19.16 | 9.95 | 153 | 144297 | 39434 | 64314848 |
Postictal state | 19.15 | 9.95 | 21 | 144429 | 1632 | 64352650 |
Rapid eye movements sleep abnormal | 19.13 | 9.95 | 10 | 144440 | 247 | 64354035 |
Failure to thrive | 19.12 | 9.95 | 59 | 144391 | 10345 | 64343937 |
CYP3A4 polymorphism | 19.10 | 9.95 | 7 | 144443 | 70 | 64354212 |
White blood cell count decreased | 19.08 | 9.95 | 244 | 144206 | 157593 | 64196689 |
Sleep terror | 18.96 | 9.95 | 18 | 144432 | 1179 | 64353103 |
Bezoar | 18.90 | 9.95 | 24 | 144426 | 2179 | 64352103 |
Neutropenia | 18.87 | 9.95 | 401 | 144049 | 239223 | 64115059 |
Cold sweat | 18.87 | 9.95 | 80 | 144370 | 16375 | 64337907 |
Tendonitis | 18.83 | 9.95 | 11 | 144439 | 20271 | 64334011 |
Thirst | 18.82 | 9.95 | 72 | 144378 | 14065 | 64340217 |
Obsessive-compulsive personality disorder | 18.80 | 9.95 | 8 | 144442 | 122 | 64354160 |
Osteonecrosis of jaw | 18.78 | 9.95 | 38 | 144412 | 39787 | 64314495 |
Binge eating | 18.73 | 9.95 | 12 | 144438 | 438 | 64353844 |
Self-injurious ideation | 18.73 | 9.95 | 29 | 144421 | 3168 | 64351114 |
Amnestic disorder | 18.68 | 9.95 | 13 | 144437 | 546 | 64353736 |
Psychomotor skills impaired | 18.62 | 9.95 | 32 | 144418 | 3813 | 64350469 |
Wound | 18.58 | 9.95 | 98 | 144352 | 76379 | 64277903 |
Eosinophilic pleural effusion | 18.56 | 9.95 | 10 | 144440 | 263 | 64354019 |
Coronary artery disease | 18.55 | 9.95 | 71 | 144379 | 60362 | 64293920 |
Drug dose titration not performed | 18.53 | 9.95 | 14 | 144436 | 669 | 64353613 |
Anaphylactic reaction | 18.40 | 9.95 | 85 | 144365 | 68579 | 64285703 |
Stoma site inflammation | 18.37 | 9.95 | 13 | 144437 | 561 | 64353721 |
Therapeutic product effect incomplete | 18.32 | 9.95 | 146 | 144304 | 103336 | 64250946 |
Hypersomnia | 18.25 | 9.95 | 90 | 144360 | 19627 | 64334655 |
Dementia with Lewy bodies | 18.10 | 9.95 | 14 | 144436 | 693 | 64353589 |
Salivary hypersecretion | 18.07 | 9.95 | 64 | 144386 | 12049 | 64342233 |
Natural killer cell count decreased | 18.00 | 9.95 | 6 | 144444 | 44 | 64354238 |
Tracheal pain | 18.00 | 9.95 | 6 | 144444 | 44 | 64354238 |
Paralysis | 17.93 | 9.95 | 62 | 144388 | 11533 | 64342749 |
Skin necrosis | 17.80 | 9.95 | 5 | 144445 | 14324 | 64339958 |
Renal failure | 17.73 | 9.95 | 293 | 144157 | 181395 | 64172887 |
Tachypnoea | 17.72 | 9.95 | 111 | 144339 | 26460 | 64327822 |
Cyanosis | 17.65 | 9.95 | 97 | 144353 | 22058 | 64332224 |
Neglect of personal appearance | 17.65 | 9.95 | 8 | 144442 | 143 | 64354139 |
Haemoglobin decreased | 17.61 | 9.95 | 319 | 144131 | 194744 | 64159538 |
Conjunctivitis | 17.57 | 9.95 | 12 | 144438 | 20342 | 64333940 |
Sputum discoloured | 17.57 | 9.95 | 9 | 144441 | 17847 | 64336435 |
Electrocardiogram QRS complex prolonged | 17.53 | 9.95 | 53 | 144397 | 9191 | 64345091 |
Negative thoughts | 17.50 | 9.95 | 18 | 144432 | 1300 | 64352982 |
Emotional disorder | 17.44 | 9.95 | 65 | 144385 | 12542 | 64341740 |
Mitral valve incompetence | 17.26 | 9.95 | 19 | 144431 | 25519 | 64328763 |
Haemophagocytic lymphohistiocytosis | 17.14 | 9.95 | 9 | 144441 | 17600 | 64336682 |
Postoperative respiratory failure | 17.11 | 9.95 | 8 | 144442 | 154 | 64354128 |
Skin lesion | 17.04 | 9.95 | 35 | 144415 | 36447 | 64317835 |
Disinhibition | 17.02 | 9.95 | 23 | 144427 | 2220 | 64352062 |
Communication disorder | 16.85 | 9.95 | 30 | 144420 | 3676 | 64350606 |
Treatment noncompliance | 16.84 | 9.95 | 160 | 144290 | 43322 | 64310960 |
Blood osmolarity decreased | 16.83 | 9.95 | 17 | 144433 | 1201 | 64353081 |
Haemoptysis | 16.81 | 9.95 | 55 | 144395 | 48993 | 64305289 |
Antidepressant drug level decreased | 16.76 | 9.95 | 4 | 144446 | 6 | 64354276 |
Sensorimotor disorder | 16.68 | 9.95 | 14 | 144436 | 779 | 64353503 |
Stoma site erythema | 16.59 | 9.95 | 17 | 144433 | 1222 | 64353060 |
Facial nerve disorder | 16.55 | 9.95 | 13 | 144437 | 658 | 64353624 |
Wrong technique in product usage process | 16.50 | 9.95 | 82 | 144368 | 64892 | 64289390 |
Loose associations | 16.46 | 9.95 | 6 | 144444 | 59 | 64354223 |
Anorgasmia | 16.44 | 9.95 | 15 | 144435 | 934 | 64353348 |
Respiratory acidosis | 16.39 | 9.95 | 54 | 144396 | 9801 | 64344481 |
Swollen tongue | 16.32 | 9.95 | 134 | 144316 | 34820 | 64319462 |
Decreased interest | 16.32 | 9.95 | 28 | 144422 | 3332 | 64350950 |
Respiratory rate decreased | 16.27 | 9.95 | 33 | 144417 | 4458 | 64349824 |
Drug screen positive | 16.09 | 9.95 | 38 | 144412 | 5691 | 64348591 |
Status epilepticus | 16.04 | 9.95 | 93 | 144357 | 21570 | 64332712 |
Hypervigilance | 16.04 | 9.95 | 11 | 144439 | 451 | 64353831 |
Premature delivery | 15.99 | 9.95 | 11 | 144439 | 18578 | 64335704 |
Rash maculo-papular | 15.93 | 9.95 | 53 | 144397 | 46973 | 64307309 |
Dementia | 15.93 | 9.95 | 90 | 144360 | 20676 | 64333606 |
Staphylococcal infection | 15.91 | 9.95 | 59 | 144391 | 50619 | 64303663 |
Purple glove syndrome | 15.91 | 9.95 | 9 | 144441 | 261 | 64354021 |
Tricuspid valve sclerosis | 15.86 | 9.95 | 5 | 144445 | 30 | 64354252 |
Flushing | 15.82 | 9.95 | 107 | 144343 | 78541 | 64275741 |
Acne | 15.79 | 9.95 | 17 | 144433 | 23064 | 64331218 |
Homicide | 15.79 | 9.95 | 16 | 144434 | 1135 | 64353147 |
Circadian rhythm sleep disorder | 15.76 | 9.95 | 12 | 144438 | 580 | 64353702 |
Sensory disturbance | 15.76 | 9.95 | 65 | 144385 | 13143 | 64341139 |
Antidepressant drug level increased | 15.73 | 9.95 | 10 | 144440 | 360 | 64353922 |
Autonomic nervous system imbalance | 15.73 | 9.95 | 31 | 144419 | 4101 | 64350181 |
Hepatic steatosis | 15.64 | 9.95 | 121 | 144329 | 30886 | 64323396 |
Renal disorder | 15.63 | 9.95 | 35 | 144415 | 35330 | 64318952 |
Frequent bowel movements | 15.53 | 9.95 | 11 | 144439 | 18294 | 64335988 |
Gout | 15.53 | 9.95 | 15 | 144435 | 21398 | 64332884 |
Dyspraxia | 15.51 | 9.95 | 9 | 144441 | 274 | 64354008 |
Neoplasm progression | 15.42 | 9.95 | 44 | 144406 | 40920 | 64313362 |
Rash pruritic | 15.42 | 9.95 | 71 | 144379 | 57333 | 64296949 |
Haematemesis | 15.36 | 9.95 | 167 | 144283 | 46832 | 64307450 |
Bacterial infection | 15.33 | 9.95 | 20 | 144430 | 24930 | 64329352 |
Drowning | 15.30 | 9.95 | 13 | 144437 | 736 | 64353546 |
Cerebral mass effect | 15.30 | 9.95 | 19 | 144431 | 1687 | 64352595 |
Tachycardia paroxysmal | 15.21 | 9.95 | 10 | 144440 | 382 | 64353900 |
Postmortem blood drug level increased | 15.12 | 9.95 | 13 | 144437 | 748 | 64353534 |
Giant cell arteritis | 15.07 | 9.95 | 22 | 144428 | 2281 | 64352001 |
Self esteem decreased | 14.93 | 9.95 | 14 | 144436 | 903 | 64353379 |
Skin exfoliation | 14.93 | 9.95 | 51 | 144399 | 44834 | 64309448 |
Diverticulitis | 14.89 | 9.95 | 41 | 144409 | 38577 | 64315705 |
Neck pain | 14.86 | 9.95 | 79 | 144371 | 61454 | 64292828 |
Psychotic symptom | 14.84 | 9.95 | 21 | 144429 | 2117 | 64352165 |
Prostatism | 14.69 | 9.95 | 6 | 144444 | 82 | 64354200 |
Joint range of motion decreased | 14.68 | 9.95 | 13 | 144437 | 19330 | 64334952 |
Food craving | 14.64 | 9.95 | 17 | 144433 | 1407 | 64352875 |
Therapy non-responder | 14.62 | 9.95 | 87 | 144363 | 65812 | 64288470 |
Skin ulcer | 14.60 | 9.95 | 50 | 144400 | 43924 | 64310358 |
Immune reconstitution inflammatory syndrome | 14.59 | 9.95 | 61 | 144389 | 12409 | 64341873 |
Dissociative disorder | 14.56 | 9.95 | 10 | 144440 | 411 | 64353871 |
Hypothermia | 14.54 | 9.95 | 85 | 144365 | 19771 | 64334511 |
Hypervolaemia | 14.50 | 9.95 | 41 | 144409 | 38244 | 64316038 |
Epstein-Barr virus infection | 14.36 | 9.95 | 5 | 144445 | 12483 | 64341799 |
Disseminated intravascular coagulation | 14.30 | 9.95 | 32 | 144418 | 32316 | 64321966 |
Blood sodium decreased | 14.29 | 9.95 | 114 | 144336 | 29368 | 64324914 |
Thrombosis | 14.26 | 9.95 | 96 | 144354 | 70546 | 64283736 |
Blood osmolarity increased | 14.26 | 9.95 | 11 | 144439 | 542 | 64353740 |
JC virus CSF test positive | 14.16 | 9.95 | 7 | 144443 | 153 | 64354129 |
Somatic delusion | 14.14 | 9.95 | 12 | 144438 | 678 | 64353604 |
Ear infection | 14.14 | 9.95 | 19 | 144431 | 23385 | 64330897 |
Sexual dysfunction | 14.10 | 9.95 | 39 | 144411 | 6432 | 64347850 |
Second primary malignancy | 14.08 | 9.95 | 5 | 144445 | 12332 | 64341950 |
Violence-related symptom | 14.07 | 9.95 | 12 | 144438 | 683 | 64353599 |
Paresis | 14.06 | 9.95 | 27 | 144423 | 3505 | 64350777 |
Hyperthyroidism | 14.06 | 9.95 | 12 | 144438 | 18167 | 64336115 |
Somatic symptom disorder | 13.94 | 9.95 | 19 | 144431 | 1849 | 64352433 |
Fear | 13.91 | 9.95 | 85 | 144365 | 20086 | 64334196 |
Dry mouth | 13.87 | 9.95 | 201 | 144249 | 60217 | 64294065 |
Emotional poverty | 13.86 | 9.95 | 12 | 144438 | 697 | 64353585 |
Vertigo | 13.82 | 9.95 | 197 | 144253 | 58814 | 64295468 |
Decreased appetite | 13.80 | 9.95 | 766 | 143684 | 280523 | 64073759 |
Cardiac failure | 13.73 | 9.95 | 211 | 144239 | 132162 | 64222120 |
Limited symptom panic attack | 13.73 | 9.95 | 5 | 144445 | 49 | 64354233 |
Drop attacks | 13.72 | 9.95 | 14 | 144436 | 1001 | 64353281 |
Aspergillus infection | 13.69 | 9.95 | 10 | 144440 | 16369 | 64337913 |
Drug abuser | 13.66 | 9.95 | 36 | 144414 | 5772 | 64348510 |
Suspiciousness | 13.62 | 9.95 | 11 | 144439 | 580 | 64353702 |
Impaired self-care | 13.57 | 9.95 | 21 | 144429 | 2292 | 64351990 |
Hepatotoxicity | 13.57 | 9.95 | 45 | 144405 | 39917 | 64314365 |
Hypertension | 13.55 | 9.95 | 460 | 143990 | 258801 | 64095481 |
Cytokine release syndrome | 13.53 | 9.95 | 16 | 144434 | 20813 | 64333469 |
Wrong product administered | 13.47 | 9.95 | 43 | 144407 | 7677 | 64346605 |
Sinus congestion | 13.47 | 9.95 | 9 | 144441 | 15430 | 64338852 |
Orgasm abnormal | 13.46 | 9.95 | 7 | 144443 | 171 | 64354111 |
Panic disorder | 13.42 | 9.95 | 23 | 144427 | 2734 | 64351548 |
Oral herpes | 13.37 | 9.95 | 18 | 144432 | 22134 | 64332148 |
Pulmonary oedema | 13.33 | 9.95 | 249 | 144201 | 78425 | 64275857 |
Dysphoria | 13.31 | 9.95 | 30 | 144420 | 4358 | 64349924 |
Indifference | 13.29 | 9.95 | 8 | 144442 | 261 | 64354021 |
Sinus disorder | 13.27 | 9.95 | 11 | 144439 | 16897 | 64337385 |
Dependence | 13.26 | 9.95 | 20 | 144430 | 2135 | 64352147 |
Blood pressure systolic abnormal | 13.25 | 9.95 | 3 | 144447 | 9939 | 64344343 |
Blood creatinine increased | 13.23 | 9.95 | 219 | 144231 | 135563 | 64218719 |
Mass | 13.20 | 9.95 | 9 | 144441 | 15267 | 64339015 |
Vasodilatation | 13.17 | 9.95 | 24 | 144426 | 2994 | 64351288 |
Dysgraphia | 13.17 | 9.95 | 26 | 144424 | 3445 | 64350837 |
Kidney congestion | 13.16 | 9.95 | 8 | 144442 | 266 | 64354016 |
Lymphadenopathy | 12.98 | 9.95 | 57 | 144393 | 46629 | 64307653 |
Poverty of thought content | 12.98 | 9.95 | 5 | 144445 | 58 | 64354224 |
Personality disorder | 12.96 | 9.95 | 31 | 144419 | 4680 | 64349602 |
Compulsive shopping | 12.91 | 9.95 | 12 | 144438 | 765 | 64353517 |
Kussmaul respiration | 12.72 | 9.95 | 9 | 144441 | 388 | 64353894 |
Injection site rash | 12.66 | 9.95 | 10 | 144440 | 15732 | 64338550 |
Ballismus | 12.63 | 9.95 | 7 | 144443 | 195 | 64354087 |
Dyspnoea exertional | 12.60 | 9.95 | 105 | 144345 | 73625 | 64280657 |
Blood ethanol increased | 12.59 | 9.95 | 11 | 144439 | 647 | 64353635 |
Resuscitation | 12.57 | 9.95 | 19 | 144431 | 2032 | 64352250 |
Dystrophic calcification | 12.53 | 9.95 | 6 | 144444 | 122 | 64354160 |
Antiphospholipid antibodies | 12.53 | 9.95 | 6 | 144444 | 122 | 64354160 |
Spinal cord injury thoracic | 12.53 | 9.95 | 6 | 144444 | 122 | 64354160 |
Pneumocystis jirovecii pneumonia | 12.50 | 9.95 | 27 | 144423 | 27607 | 64326675 |
Polydipsia psychogenic | 12.44 | 9.95 | 7 | 144443 | 201 | 64354081 |
Surgery | 12.40 | 9.95 | 28 | 144422 | 28185 | 64326097 |
Visceral congestion | 12.34 | 9.95 | 12 | 144438 | 810 | 64353472 |
Oedema | 12.30 | 9.95 | 139 | 144311 | 91796 | 64262486 |
Drug resistance | 12.28 | 9.95 | 39 | 144411 | 35063 | 64319219 |
Loss of proprioception | 12.25 | 9.95 | 11 | 144439 | 671 | 64353611 |
Light chain disease | 12.22 | 9.95 | 7 | 144443 | 208 | 64354074 |
Hangover | 12.21 | 9.95 | 18 | 144432 | 1883 | 64352399 |
Agonal rhythm | 12.20 | 9.95 | 5 | 144445 | 69 | 64354213 |
Cellulitis orbital | 12.18 | 9.95 | 11 | 144439 | 676 | 64353606 |
Ascites | 12.15 | 9.95 | 85 | 144365 | 61916 | 64292366 |
Pulmonary vein occlusion | 12.15 | 9.95 | 6 | 144444 | 131 | 64354151 |
Reduced facial expression | 12.14 | 9.95 | 19 | 144431 | 2094 | 64352188 |
Generalised anxiety disorder | 12.11 | 9.95 | 18 | 144432 | 1897 | 64352385 |
Respiratory tract congestion | 12.10 | 9.95 | 11 | 144439 | 16154 | 64338128 |
Pulmonary fibrosis | 12.07 | 9.95 | 31 | 144419 | 29847 | 64324435 |
Ocular hyperaemia | 12.00 | 9.95 | 20 | 144430 | 22544 | 64331738 |
Injection site urticaria | 11.99 | 9.95 | 5 | 144445 | 11176 | 64343106 |
Eosinophilic myocarditis | 11.97 | 9.95 | 12 | 144438 | 840 | 64353442 |
Spontaneous haemorrhage | 11.97 | 9.95 | 9 | 144441 | 427 | 64353855 |
Increased tendency to bruise | 11.93 | 9.95 | 3 | 144447 | 9252 | 64345030 |
Post-traumatic stress disorder | 11.93 | 9.95 | 28 | 144422 | 4177 | 64350105 |
Arachnoid cyst | 11.93 | 9.95 | 8 | 144442 | 316 | 64353966 |
Sneezing | 11.87 | 9.95 | 10 | 144440 | 15241 | 64339041 |
Jealous delusion | 11.87 | 9.95 | 7 | 144443 | 220 | 64354062 |
Migraine | 11.76 | 9.95 | 87 | 144363 | 62590 | 64291692 |
Oxygen saturation decreased | 11.75 | 9.95 | 169 | 144281 | 107007 | 64247275 |
B-lymphocyte count increased | 11.75 | 9.95 | 6 | 144444 | 141 | 64354141 |
Foot fracture | 11.74 | 9.95 | 14 | 144436 | 18143 | 64336139 |
Blood pressure diastolic abnormal | 11.74 | 9.95 | 6 | 144444 | 11911 | 64342371 |
Haemolysis | 11.73 | 9.95 | 5 | 144445 | 11034 | 64343248 |
Repetitive speech | 11.73 | 9.95 | 8 | 144442 | 325 | 64353957 |
Pulmonary renal syndrome | 11.72 | 9.95 | 10 | 144440 | 569 | 64353713 |
Accidental exposure to product | 11.72 | 9.95 | 26 | 144424 | 26338 | 64327944 |
Oesophageal haemorrhage | 11.65 | 9.95 | 16 | 144434 | 1568 | 64352714 |
Localised infection | 11.65 | 9.95 | 32 | 144418 | 30129 | 64324153 |
Labelled drug-drug interaction medication error | 11.64 | 9.95 | 87 | 144363 | 21975 | 64332307 |
Libido decreased | 11.60 | 9.95 | 30 | 144420 | 4754 | 64349528 |
Abdominal rigidity | 11.60 | 9.95 | 21 | 144429 | 2606 | 64351676 |
Bacteraemia | 11.59 | 9.95 | 27 | 144423 | 26884 | 64327398 |
Inferior vena caval occlusion | 11.59 | 9.95 | 4 | 144446 | 33 | 64354249 |
Bronchial aspiration procedure | 11.59 | 9.95 | 7 | 144443 | 230 | 64354052 |
Alkalosis hypochloraemic | 11.54 | 9.95 | 9 | 144441 | 451 | 64353831 |
Injection site warmth | 11.54 | 9.95 | 8 | 144442 | 13454 | 64340828 |
Medulloblastoma | 11.48 | 9.95 | 5 | 144445 | 81 | 64354201 |
COVID-19 pneumonia | 11.46 | 9.95 | 12 | 144438 | 16492 | 64337790 |
Red blood cell sedimentation rate increased | 11.43 | 9.95 | 34 | 144416 | 31201 | 64323081 |
Rabbit syndrome | 11.41 | 9.95 | 8 | 144442 | 340 | 64353942 |
Implant site extravasation | 11.40 | 9.95 | 11 | 144439 | 735 | 64353547 |
Sudden cardiac death | 11.37 | 9.95 | 29 | 144421 | 4558 | 64349724 |
Pathogen resistance | 11.37 | 9.95 | 7 | 144443 | 12536 | 64341746 |
Cytomegalovirus viraemia | 11.36 | 9.95 | 5 | 144445 | 10823 | 64343459 |
Abscess | 11.33 | 9.95 | 16 | 144434 | 19288 | 64334994 |
Pulmonary arterial hypertension | 11.29 | 9.95 | 25 | 144425 | 25342 | 64328940 |
Sialoadenitis | 11.27 | 9.95 | 16 | 144434 | 1617 | 64352665 |
Gamma-glutamyltransferase abnormal | 11.22 | 9.95 | 9 | 144441 | 470 | 64353812 |
Drug withdrawal headache | 11.20 | 9.95 | 5 | 144445 | 86 | 64354196 |
Perforated ulcer | 11.20 | 9.95 | 10 | 144440 | 605 | 64353677 |
Disorganised speech | 11.14 | 9.95 | 16 | 144434 | 1634 | 64352648 |
Adrenal cyst | 11.10 | 9.95 | 5 | 144445 | 88 | 64354194 |
Insulin resistance | 11.09 | 9.95 | 13 | 144437 | 1087 | 64353195 |
Rebound effect | 11.08 | 9.95 | 30 | 144420 | 4887 | 64349395 |
Lung disorder | 11.04 | 9.95 | 85 | 144365 | 60615 | 64293667 |
Electroencephalogram abnormal | 10.99 | 9.95 | 31 | 144419 | 5172 | 64349110 |
Hypertriglyceridaemia | 10.98 | 9.95 | 52 | 144398 | 11153 | 64343129 |
Mood disorder due to a general medical condition | 10.91 | 9.95 | 4 | 144446 | 40 | 64354242 |
Immunodeficiency | 10.89 | 9.95 | 12 | 144438 | 16112 | 64338170 |
Verbal abuse | 10.89 | 9.95 | 7 | 144443 | 257 | 64354025 |
Memory impairment | 10.88 | 9.95 | 260 | 144190 | 85422 | 64268860 |
Peritonitis | 10.86 | 9.95 | 25 | 144425 | 24998 | 64329284 |
Enthesopathy | 10.84 | 9.95 | 4 | 144446 | 9634 | 64344648 |
Hypernatraemia | 10.83 | 9.95 | 55 | 144395 | 12134 | 64342148 |
Pharyngitis streptococcal | 10.81 | 9.95 | 3 | 144447 | 8665 | 64345617 |
Coagulopathy | 10.80 | 9.95 | 36 | 144414 | 31884 | 64322398 |
Tenderness | 10.78 | 9.95 | 17 | 144433 | 19585 | 64334697 |
Drug eruption | 10.74 | 9.95 | 43 | 144407 | 36093 | 64318189 |
Malignant melanoma | 10.72 | 9.95 | 8 | 144442 | 12956 | 64341326 |
Cachexia | 10.71 | 9.95 | 45 | 144405 | 9172 | 64345110 |
Wheezing | 10.71 | 9.95 | 122 | 144328 | 80457 | 64273825 |
Paraesthesia | 10.71 | 9.95 | 385 | 144065 | 134137 | 64220145 |
Carbon monoxide poisoning | 10.70 | 9.95 | 7 | 144443 | 265 | 64354017 |
Shared psychotic disorder | 10.66 | 9.95 | 4 | 144446 | 43 | 64354239 |
Haematotoxicity | 10.61 | 9.95 | 8 | 144442 | 12888 | 64341394 |
Creatinine renal clearance decreased | 10.58 | 9.95 | 10 | 144440 | 14411 | 64339871 |
Prescription drug used without a prescription | 10.50 | 9.95 | 20 | 144430 | 2580 | 64351702 |
Amnesia | 10.46 | 9.95 | 159 | 144291 | 48110 | 64306172 |
Nausea | 10.41 | 9.95 | 1573 | 142877 | 784227 | 63570055 |
Lower limb fracture | 10.40 | 9.95 | 9 | 144441 | 13536 | 64340746 |
Hyperprolactinaemia | 10.39 | 9.95 | 26 | 144424 | 4039 | 64350243 |
Skin infection | 10.37 | 9.95 | 11 | 144439 | 15026 | 64339256 |
Chemical burns of eye | 10.34 | 9.95 | 5 | 144445 | 104 | 64354178 |
Peripheral T-cell lymphoma unspecified recurrent | 10.34 | 9.95 | 4 | 144446 | 47 | 64354235 |
Fibromyalgia | 10.32 | 9.95 | 43 | 144407 | 35688 | 64318594 |
Gambling | 10.31 | 9.95 | 7 | 144443 | 282 | 64354000 |
Coordination abnormal | 10.28 | 9.95 | 63 | 144387 | 14901 | 64339381 |
Pericardial effusion | 10.28 | 9.95 | 49 | 144401 | 39205 | 64315077 |
Unemployment | 10.26 | 9.95 | 4 | 144446 | 48 | 64354234 |
Hyperuricaemia | 10.23 | 9.95 | 5 | 144445 | 10186 | 64344096 |
Hypokalaemia | 10.23 | 9.95 | 351 | 144099 | 121552 | 64232730 |
Melaena | 10.21 | 9.95 | 74 | 144376 | 53474 | 64300808 |
Gallbladder enlargement | 10.19 | 9.95 | 14 | 144436 | 1372 | 64352910 |
Viral infection | 10.13 | 9.95 | 44 | 144406 | 36096 | 64318186 |
Bladder cancer | 10.12 | 9.95 | 6 | 144444 | 10968 | 64343314 |
Autoscopy | 10.12 | 9.95 | 4 | 144446 | 50 | 64354232 |
Mixed anxiety and depressive disorder | 10.05 | 9.95 | 6 | 144444 | 193 | 64354089 |
Personality change | 10.03 | 9.95 | 42 | 144408 | 8551 | 64345731 |
Aspergillus test positive | 10.00 | 9.95 | 10 | 144440 | 698 | 64353584 |
Post viral fatigue syndrome | 9.99 | 9.95 | 7 | 144443 | 297 | 64353985 |
Resting tremor | 9.98 | 9.95 | 14 | 144436 | 1400 | 64352882 |
Feeling drunk | 9.97 | 9.95 | 26 | 144424 | 4141 | 64350141 |
Brain oedema | 9.97 | 9.95 | 84 | 144366 | 21991 | 64332291 |
Product confusion | 9.97 | 9.95 | 3 | 144447 | 15 | 64354267 |
Toxicologic test abnormal | 9.97 | 9.95 | 13 | 144437 | 1212 | 64353070 |
Flight of ideas | 9.97 | 9.95 | 10 | 144440 | 701 | 64353581 |
None
Source | Code | Description |
---|---|---|
ATC | N06AX11 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Other antidepressants |
MeSH PA | D018663 | Adrenergic Agents |
MeSH PA | D058669 | Adrenergic alpha-2 Receptor Antagonists |
MeSH PA | D000317 | Adrenergic alpha-Antagonists |
MeSH PA | D018674 | Adrenergic Antagonists |
MeSH PA | D014151 | Anti-Anxiety Agents |
MeSH PA | D000928 | Antidepressive Agents |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D018494 | Histamine Agents |
MeSH PA | D006633 | Histamine Antagonists |
MeSH PA | D006634 | Histamine H1 Antagonists |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D011619 | Psychotropic Drugs |
MeSH PA | D058830 | Serotonin 5-HT2 Receptor Antagonists |
MeSH PA | D058831 | Serotonin 5-HT3 Receptor Antagonists |
MeSH PA | D018490 | Serotonin Agents |
MeSH PA | D012702 | Serotonin Antagonists |
MeSH PA | D014149 | Tranquilizing Agents |
CHEBI has role | CHEBI:35474 | anti-anxiety agents |
CHEBI has role | CHEBI:37890 | alpha-adrenergic receptor blockaders |
CHEBI has role | CHEBI:37955 | H1 receptor antagonists |
CHEBI has role | CHEBI:37956 | antihistamines |
CHEBI has role | CHEBI:48279 | serotonin antagonists |
CHEBI has role | CHEBI:146270 | oneirogens |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Major depressive disorder | indication | 370143000 | |
Excessive vomiting in pregnancy | off-label use | 14094001 | |
Posttraumatic stress disorder | off-label use | 47505003 | DOID:2055 |
Suicidal thoughts | contraindication | 6471006 | |
Weight gain finding | contraindication | 8943002 | |
Hypercholesterolemia | contraindication | 13644009 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Hypovolemia | contraindication | 28560003 | |
Orthostatic hypotension | contraindication | 28651003 | |
Dehydration | contraindication | 34095006 | |
Low blood pressure | contraindication | 45007003 | |
Cerebrovascular disease | contraindication | 62914000 | DOID:6713 |
Hyponatremia | contraindication | 89627008 | |
Seizure disorder | contraindication | 128613002 | |
Liver function tests abnormal | contraindication | 166603001 | |
Bipolar affective disorder, current episode manic | contraindication | 191618007 | |
Angina pectoris | contraindication | 194828000 | |
Impaired renal function disorder | contraindication | 197663003 | |
Cerebrovascular accident | contraindication | 230690007 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Akathisia | contraindication | 285145004 | |
Hypertriglyceridemia | contraindication | 302870006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Serotonin syndrome | contraindication | 371089000 | |
Obesity | contraindication | 414916001 | DOID:9970 |
Acute Thromboembolic Stroke | contraindication |
Species | Use | Relation |
---|---|---|
Cats | Management of weight loss in cats | Indication |
Product | Applicant | Ingredients |
---|---|---|
Mirataz | Dechra, Ltd. | 1 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.67 | Basic |
pKa2 | 2.91 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
5-hydroxytryptamine receptor 2C | GPCR | ANTAGONIST | Ki | 7.41 | CHEMBL | CHEMBL | |||
5-hydroxytryptamine receptor 2A | GPCR | ANTAGONIST | Ki | 7.16 | CHEMBL | CHEMBL | |||
Alpha-2A adrenergic receptor | GPCR | ANTAGONIST | Ki | 7.70 | CHEMBL | ||||
Sodium-dependent noradrenaline transporter | Transporter | Ki | 5.34 | PDSP | |||||
5-hydroxytryptamine receptor 1A | GPCR | Kd | 5.30 | CHEMBL | |||||
5-hydroxytryptamine receptor 7 | GPCR | Ki | 6.58 | CHEMBL | |||||
Alpha-1A adrenergic receptor | GPCR | IC50 | 5.50 | CHEMBL | |||||
Alpha-2B adrenergic receptor | GPCR | ANTAGONIST | IC50 | 6.65 | CHEMBL | ||||
D(3) dopamine receptor | GPCR | Ki | 5.24 | CHEMBL | |||||
Histamine H1 receptor | GPCR | Ki | 8.80 | WOMBAT-PK | |||||
Muscarinic acetylcholine receptor M1 | GPCR | WOMBAT-PK | |||||||
Muscarinic acetylcholine receptor M2 | GPCR | WOMBAT-PK | |||||||
Alpha-2C adrenergic receptor | GPCR | ANTAGONIST | Ki | 7.74 | CHEMBL | ||||
5-hydroxytryptamine receptor 3A | Ion channel | Ki | 5.54 | CHEMBL | |||||
D(1A) dopamine receptor | GPCR | Ki | 5.38 | PDSP | |||||
D(2) dopamine receptor | GPCR | Ki | 5.26 | PDSP | |||||
D(2) dopamine receptor | GPCR | Ki | 5.84 | CHEMBL | |||||
5-hydroxytryptamine receptor 2A | GPCR | Ki | 8.70 | CHEMBL | |||||
Transporter | Transporter | Ki | 5.79 | CHEMBL | |||||
D(1A) dopamine receptor | GPCR | Ki | 5.38 | CHEMBL | |||||
5-hydroxytryptamine receptor 2C | GPCR | Ki | 8.26 | CHEMBL | |||||
Adrenergic receptor alpha-1 | GPCR | Ki | 6.22 | CHEMBL |
ID | Source |
---|---|
4020978 | VUID |
N0000148449 | NUI |
D00563 | KEGG_DRUG |
4020978 | VANDF |
C0049506 | UMLSCUI |
CHEBI:6950 | CHEBI |
CHEMBL654 | ChEMBL_ID |
DB00370 | DRUGBANK_ID |
D000078785 | MESH_DESCRIPTOR_UI |
4205 | PUBCHEM_CID |
7241 | IUPHAR_LIGAND_ID |
6481 | INN_ID |
A051Q2099Q | UNII |
15996 | RXNORM |
46110 | MMSL |
5120 | MMSL |
d04025 | MMSL |
006054 | NDDF |
108430001 | SNOMEDCT_US |
386847004 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
REMERON | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-0105 | TABLET, FILM COATED | 15 mg | ORAL | NDA | 31 sections |
REMERONSOLTAB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-0106 | TABLET, ORALLY DISINTEGRATING | 15 mg | ORAL | NDA | 31 sections |
REMERON | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-0107 | TABLET, FILM COATED | 30 mg | ORAL | NDA | 31 sections |
REMERONSOLTAB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-0108 | TABLET, ORALLY DISINTEGRATING | 30 mg | ORAL | NDA | 31 sections |
REMERON | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-0109 | TABLET, FILM COATED | 45 mg | ORAL | NDA | 31 sections |
REMERONSOLTAB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-0110 | TABLET, ORALLY DISINTEGRATING | 45 mg | ORAL | NDA | 31 sections |
REMERON | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-4364 | TABLET, FILM COATED | 15 mg | ORAL | NDA | 31 sections |
REMERON | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0052-4365 | TABLET, FILM COATED | 30 mg | ORAL | NDA | 31 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3515 | TABLET, FILM COATED | 15 mg | ORAL | ANDA | 29 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3530 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 29 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-3545 | TABLET, FILM COATED | 45 mg | ORAL | ANDA | 29 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8078 | TABLET | 7.50 mg | ORAL | ANDA | 25 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8268 | TABLET, FILM COATED | 15 mg | ORAL | ANDA | 25 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0615-8269 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 25 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6519 | TABLET, FILM COATED | 15 mg | ORAL | ANDA | 25 sections |
Mirtazapine | Human Prescription Drug Label | 1 | 13107-001 | TABLET, FILM COATED | 7.50 mg | ORAL | ANDA | 28 sections |
Mirtazapine | Human Prescription Drug Label | 1 | 13107-001 | TABLET, FILM COATED | 7.50 mg | ORAL | ANDA | 28 sections |
Mirtazapine | Human Prescription Drug Label | 1 | 13107-003 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 28 sections |
Mirtazapine | Human Prescription Drug Label | 1 | 13107-003 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 28 sections |
Mirtazapine | Human Prescription Drug Label | 1 | 13107-031 | TABLET, FILM COATED | 15 mg | ORAL | ANDA | 28 sections |
Mirtazapine | Human Prescription Drug Label | 1 | 13107-031 | TABLET, FILM COATED | 15 mg | ORAL | ANDA | 28 sections |
Mirtazapine | Human Prescription Drug Label | 1 | 13107-032 | TABLET, FILM COATED | 45 mg | ORAL | ANDA | 28 sections |
Mirtazapine | Human Prescription Drug Label | 1 | 13107-032 | TABLET, FILM COATED | 45 mg | ORAL | ANDA | 28 sections |
MIRTAZAPINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-153 | TABLET, FILM COATED | 15 mg | ORAL | ANDA | 26 sections |
MIRTAZAPINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-154 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 26 sections |
MIRTAZAPINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-155 | TABLET, FILM COATED | 45 mg | ORAL | ANDA | 26 sections |
Mirtazapine | Human Prescription Drug Label | 1 | 17856-0101 | TABLET, FILM COATED | 7.50 mg | ORAL | ANDA | 25 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-081 | TABLET, FILM COATED | 15 mg | ORAL | ANDA | 29 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-082 | TABLET, FILM COATED | 30 mg | ORAL | ANDA | 29 sections |
Mirtazapine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-083 | TABLET, FILM COATED | 45 mg | ORAL | ANDA | 29 sections |