mimosine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1811 500-44-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mimosine
  • L-Mimosine
  • leucaenine
  • leucaenol
  • leucenine
  • leucenol
  • mimosin
3-Hydroxy-4-oxo-1(4H)-pyridinealanine. An antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca.
  • Molecular weight: 198.18
  • Formula: C8H10N2O4
  • CLOGP: -4.07
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 3
  • TPSA: 103.86
  • ALOGS: -1.18
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

None

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.03 acidic
pKa2 9.0 acidic
pKa3 6.51 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Tyrosinase Enzyme IC50 5.43 WOMBAT-PK
Serine hydroxymethyltransferase, cytosolic Enzyme WOMBAT-PK
Ribonucleoside-diphosphate reductase large subunit Enzyme IC50 4.39 WOMBAT-PK
Polyphenol oxidase 2 Enzyme IC50 5.43 CHEMBL

External reference:

IDSource
87931005 SNOMEDCT_US
3862 PUBCHEM_CID
CHEBI:77689 CHEBI
CHEMBL245416 ChEMBL_ID
CHEMBL251433 ChEMBL_ID
DB01055 DRUGBANK_ID
CHEMBL502477 ChEMBL_ID
MMS PDB_CHEM_ID
Z46B1LUI5N UNII
D008898 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None