mibefradil Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers acting as vasodilators 1797 116644-53-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mibefradil
  • mibefradil dihydrochloride
  • posicor
  • Ro 40-5967
A benzimidazoyl-substituted tetraline that selectively binds and inhibits CALCIUM CHANNELS, T-TYPE.
  • Molecular weight: 495.64
  • Formula: C29H38FN3O3
  • CLOGP: 6.36
  • LIPINSKI: 1
  • HAC: 6
  • HDO: 1
  • TPSA: 67.45
  • ALOGS: -5.68
  • ROTB: 12

Drug dosage:

DoseUnitRoute
75 mg O

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.88 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Hosey CM, Chan R, Benet LZ
BA (Bioavailability) 75 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 3.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 4 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 13 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Aug. 1, 1997 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C08CX01 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Other selective calcium channel blockers with mainly vascular effects
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D065609 Cytochrome P-450 CYP1A2 Inhibitors
MeSH PA D065607 Cytochrome P-450 Enzyme Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
MeSH PA D014665 Vasodilator Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Angina pectoris indication 194828000
Complete atrioventricular block contraindication 27885002
Sick sinus syndrome contraindication 36083008 DOID:13884
Disease of liver contraindication 235856003 DOID:409
Atrioventricular Conduction Defect contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.13 acidic
pKa2 9.13 Basic
pKa3 5.62 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-dependent T-type calcium channel subunit alpha-1H Ion channel BLOCKER IC50 6.60 WOMBAT-PK SCIENTIFIC LITERATURE
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel BLOCKER IC50 4.90 IUPHAR
Multidrug resistance protein 1 Transporter IC50 5.80 WOMBAT-PK
Cytochrome P450 3A4 Enzyme Ki 6.22 WOMBAT-PK
Cation channel sperm-associated protein 1 Ion channel BLOCKER IC50 4.50 IUPHAR
Cation channel sperm-associated protein 2 Ion channel BLOCKER IC50 4.50 IUPHAR
Cation channel sperm-associated protein 3 Ion channel BLOCKER IC50 4.50 IUPHAR
Cation channel sperm-associated protein 4 Ion channel BLOCKER IC50 4.50 IUPHAR
Voltage-dependent T-type calcium channel subunit alpha-1I Ion channel IC50 6.90 CHEMBL
Voltage-dependent T-type calcium channel subunit alpha-1G Ion channel IC50 6.70 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel Ki 6.72 CHEMBL
Voltage-dependent N-type calcium channel subunit alpha-1B Ion channel IC50 5.87 CHEMBL
Voltage-dependent P/Q-type calcium channel subunit alpha-1A Unclassified GATING INHIBITOR IC50 6.50 IUPHAR
Voltage-dependent R-type calcium channel subunit alpha-1E Unclassified GATING INHIBITOR IC50 6.40 IUPHAR

External reference:

IDSource
4024074 VUID
N0000022079 NUI
C0286185 UMLSCUI
D05024 KEGG_DRUG
27B90X776A UNII
7134 INN_ID
319318006 SNOMEDCT_US
421651006 SNOMEDCT_US
4024074 VANDF
83213 RXNORM
5111 MMSL
d04139 MMSL
006710 NDDF
116666-63-8 SECONDARY_CAS_RN
CHEMBL45816 ChEMBL_ID
DB01388 DRUGBANK_ID
CHEBI:6920 CHEBI
CHEMBL1534525 ChEMBL_ID
D020748 MESH_DESCRIPTOR_UI
60663 PUBCHEM_CID
2522 IUPHAR_LIGAND_ID

Pharmaceutical products:

None