Stem definition | Drug id | CAS RN |
---|---|---|
1791 | 54-36-4 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Hosey CM, Chan R, Benet LZ |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 4, 1961 | FDA | HRA PHARMA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Cortisol increased | 132.30 | 47.35 | 18 | 599 | 376 | 56291074 |
Premature delivery | 77.79 | 47.35 | 23 | 594 | 27037 | 56264413 |
Cortisol free urine increased | 70.16 | 47.35 | 8 | 609 | 34 | 56291416 |
Pneumocystis jirovecii pneumonia | 56.89 | 47.35 | 16 | 601 | 15685 | 56275765 |
Adrenal insufficiency | 52.37 | 47.35 | 15 | 602 | 15682 | 56275768 |
None
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Cortisol increased | 118.24 | 47.06 | 17 | 871 | 464 | 70927092 |
Pneumocystis jirovecii pneumonia | 97.81 | 47.06 | 29 | 859 | 30053 | 70897503 |
Cortisol free urine increased | 86.26 | 47.06 | 10 | 878 | 43 | 70927513 |
Adrenal insufficiency | 76.26 | 47.06 | 23 | 865 | 25172 | 70902384 |
Premature delivery | 75.61 | 47.06 | 22 | 866 | 21282 | 70906274 |
None
Source | Code | Description |
---|---|---|
ATC | V04CD01 | VARIOUS DIAGNOSTIC AGENTS OTHER DIAGNOSTIC AGENTS Tests for pituitary function |
MeSH PA | D000963 | Antimetabolites |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D009676 | Noxae |
FDA MoA | N0000175921 | Adrenal Steroid Synthesis Inhibitors |
FDA EPC | N0000175928 | Adrenal Steroid Synthesis Inhibitor |
CHEBI has role | CHEBI:33295 | diagnostic aid |
CHEBI has role | CHEBI:35221 | antimetabolite |
CHEBI has role | CHEBI:76798 | cytochrome p450 XIB1 inhibitor |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Diagnostic Test for Secondary Adrenocortical Insufficiency | indication | ||
Hypercortisolism | off-label use | 47270006 | |
Primary adrenocortical insufficiency | contraindication | 373662000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.64 | Basic |
pKa2 | 1.71 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Cytochrome P450 11B1, mitochondrial | Enzyme | INHIBITOR | IC50 | 7.84 | CHEMBL | DRUG LABEL | |||
Cytochrome P450 3A4 | Enzyme | IC50 | 6.10 | DRUG MATRIX | |||||
Cytochrome P450 11B2, mitochondrial | Enzyme | IC50 | 7.38 | CHEMBL | |||||
Cytochrome P450 11B1 | Enzyme | Ki | 6.24 | CHEMBL | |||||
Cytochrome P450 11B1, mitochondrial | Enzyme | IC50 | 5.34 | CHEMBL |
ID | Source |
---|---|
4018788 | VUID |
N0000147091 | NUI |
D00410 | KEGG_DRUG |
4018788 | VANDF |
C0025876 | UMLSCUI |
CHEBI:44241 | CHEBI |
MYT | PDB_CHEM_ID |
CHEMBL934 | ChEMBL_ID |
DB01011 | DRUGBANK_ID |
D008797 | MESH_DESCRIPTOR_UI |
4174 | PUBCHEM_CID |
5224 | IUPHAR_LIGAND_ID |
1404 | INN_ID |
ZS9KD92H6V | UNII |
203002 | RXNORM |
10389 | MMSL |
5107 | MMSL |
d00592 | MMSL |
002120 | NDDF |
395794007 | SNOMEDCT_US |
53848009 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Metopirone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 76336-455 | CAPSULE, GELATIN COATED | 250 mg | ORAL | NDA | 32 sections |
Metopirone | HUMAN PRESCRIPTION DRUG LABEL | 1 | 76336-455 | CAPSULE, GELATIN COATED | 250 mg | ORAL | NDA | 32 sections |