metrizoic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1789 | 1949-45-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A diagnostic radiopaque that usually occurs as the sodium salt.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 14.64 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| Vd (Volume of distribution) | 0.17 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 2.70 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 1 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1.30 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Nov. 17, 1973 | FDA | GE HEALTHCARE |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | V08AA02 | VARIOUS CONTRAST MEDIA X-RAY CONTRAST MEDIA, IODINATED Watersoluble, nephrotropic, high osmolar X-ray contrast media |
| FDA MoA | N0000010258 | X-Ray Contrast Activity |
| MeSH PA | D003287 | Contrast Media |
| MeSH PA | D064907 | Diagnostic Uses of Chemicals |
| FDA EPC | N0000180185 | Radiographic Contrast Agent |
| CHEBI has role | CHEBI:37338 | contrast media |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.34 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| C4082771 | UMLSCUI |
| CHEBI:34847 | CHEBI |
| CHEMBL1736 | ChEMBL_ID |
| CHEMBL1200423 | ChEMBL_ID |
| D008794 | MESH_DESCRIPTOR_UI |
| DB09346 | DRUGBANK_ID |
| 20968-37-0 | SECONDARY_CAS_RN |
| 7225-61-8 | SECONDARY_CAS_RN |
| CM1N99QR1M | UNII |
| 2528 | PUBCHEM_CID |
| 000670 | NDDF |
| 000671 | NDDF |
| 354094002 | SNOMEDCT_US |
| 395792006 | SNOMEDCT_US |
| CHEMBL2068723 | ChEMBL_ID |
| CHEMBL1200353 | ChEMBL_ID |
| CHEMBL2364738 | ChEMBL_ID |
| 1378 | INN_ID |
Pharmaceutical products:
None