metixene Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1780 4969-02-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methixene hydrochloride monohydrate
  • metixene
  • methixene
  • metixen
  • tremaril
  • tremonil
  • metixene hydrochloride
  • methixene hydrochloride
  • metixene HCl
  • methixene HCl
  • Molecular weight: 309.47
  • Formula: C20H23NS
  • CLOGP: 5.84
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 0
  • TPSA: 3.24
  • ALOGS: -6.48
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
40 mg O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N04AA03 NERVOUS SYSTEM
ANTI-PARKINSON DRUGS
ANTICHOLINERGIC AGENTS
Tertiary amines
CHEBI has role CHEBI:48407 antiparkinson drug
CHEBI has role CHEBI:48876 muscarinic antagonist
CHEBI has role CHEBI:37956 histamine antagonist

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Parkinsonism indication 32798002

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.34 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M1 GPCR ANTAGONIST CHEMBL CHEMBL
5-hydroxytryptamine receptor 2C GPCR ANTAGONIST CHEMBL CHEMBL
Cholinesterase Enzyme IC50 5.80 CHEMBL

External reference:

IDSource
C0066139 UMLSCUI
D01871 KEGG_DRUG
32VY6L26ZW UNII
1582 INN_ID
64558005 SNOMEDCT_US
387354009 SNOMEDCT_US
29682 RXNORM
004712 NDDF
7081-40-5 SECONDARY_CAS_RN
DB00340 DRUGBANK_ID
CHEMBL1200426 ChEMBL_ID
CHEBI:51024 CHEBI
4167 PUBCHEM_CID
CHEMBL1201342 ChEMBL_ID
7232 IUPHAR_LIGAND_ID
C005111 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None