methylprednisolone succinate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 1771 2921-57-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methylprednisolone succinate
  • methylprednisolone hemisuccinate
  • methylprednisolone sodium succinate
A water-soluble ester of METHYLPREDNISOLONE used for cardiac, allergic, and hypoxic emergencies.
  • Molecular weight: 474.55
  • Formula: C26H34O8
  • CLOGP: 2.05
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 3
  • TPSA: 138.20
  • ALOGS: -4.25
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
May 18, 1959 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 769.74 9.44 614 211362 18682 56061409
Off label use 557.33 9.44 3787 208189 552393 55527698
Infusion related reaction 493.98 9.44 1818 210158 207113 55872978
Blood pressure fluctuation 466.21 9.44 663 211313 39697 56040394
Completed suicide 443.99 9.44 13 211963 133820 55946271
Product use in unapproved indication 431.24 9.44 1337 210639 139485 55940606
Oxygen saturation decreased 373.29 9.44 881 211095 78186 56001905
Lymphocyte count decreased 370.95 9.44 491 211485 27448 56052643
Blood pressure diastolic abnormal 343.35 9.44 311 211665 11287 56068804
Drug ineffective for unapproved indication 341.83 9.44 452 211524 25241 56054850
Glossodynia 340.99 9.44 78 211898 152380 55927711
Urine abnormality 317.02 9.44 236 211740 6463 56073628
Blood pressure systolic abnormal 314.93 9.44 275 211701 9502 56070589
Alopecia 304.89 9.44 395 211581 293063 55787028
Product dose omission issue 300.57 9.44 201 211775 204552 55875539
Transplant rejection 299.23 9.44 269 211707 9665 56070426
Pemphigus 290.75 9.44 114 211862 157098 55922993
Blood pressure increased 290.36 9.44 1199 210777 143977 55936114
Throat irritation 259.34 9.44 452 211524 32231 56047860
Death 256.54 9.44 566 211410 340860 55739231
Posterior reversible encephalopathy syndrome 253.91 9.44 307 211669 15653 56064438
Toxicity to various agents 251.41 9.44 285 211691 224279 55855812
Abdominal discomfort 248.08 9.44 414 211562 276860 55803231
Blood pressure systolic increased 245.99 9.44 502 211474 40334 56039757
Haemophagocytic lymphohistiocytosis 243.60 9.44 236 211740 9336 56070755
Aspergillus infection 238.48 9.44 209 211767 7256 56072835
Urine leukocyte esterase positive 230.83 9.44 145 211831 2983 56077108
Swelling 224.80 9.44 347 211629 239424 55840667
Multiple organ dysfunction syndrome 224.43 9.44 565 211411 52205 56027886
Cytomegalovirus viraemia 223.74 9.44 172 211804 4948 56075143
Thrombotic microangiopathy 222.70 9.44 223 211753 9188 56070903
Urinary sediment present 217.88 9.44 121 211855 1963 56078128
Arthropathy 216.80 9.44 261 211715 200014 55880077
Kidney transplant rejection 216.49 9.44 156 211820 4057 56076034
Wound 216.38 9.44 127 211849 138677 55941414
Erythema 211.59 9.44 1151 210825 154788 55925303
Red blood cells urine positive 208.09 9.44 133 211843 2823 56077268
Heart rate decreased 207.81 9.44 466 211510 39961 56040130
Contraindicated product administered 204.58 9.44 240 211736 186046 55894045
White blood cells urine positive 202.62 9.44 158 211818 4644 56075447
Bronchopulmonary aspergillosis 201.43 9.44 199 211777 8065 56072026
Systemic lupus erythematosus 199.90 9.44 230 211746 179848 55900243
Synovitis 198.18 9.44 189 211787 161116 55918975
Multiple sclerosis relapse 190.13 9.44 480 211496 44423 56035668
Hand deformity 184.20 9.44 142 211834 134350 55945741
Heart rate increased 183.36 9.44 709 211267 82564 55997527
Drug abuse 178.85 9.44 22 211954 67588 56012503
Pneumocystis jirovecii pneumonia 178.39 9.44 256 211720 15445 56064646
Blood pressure diastolic decreased 178.34 9.44 286 211690 19037 56061054
Graft versus host disease 177.86 9.44 170 211806 6611 56073480
Polyomavirus-associated nephropathy 174.32 9.44 97 211879 1580 56078511
Intentional overdose 171.12 9.44 26 211950 68091 56012000
Crystal urine present 170.68 9.44 94 211882 1499 56078592
Confusional state 170.58 9.44 328 211648 207827 55872264
Fall 167.92 9.44 734 211242 356776 55723315
Injection site pain 166.38 9.44 119 211857 116999 55963092
Cytomegalovirus test positive 164.64 9.44 113 211863 2713 56077378
Drug intolerance 163.24 9.44 485 211491 264333 55815758
Flushing 161.86 9.44 606 211370 69494 56010597
Irritable bowel syndrome 161.25 9.44 31 211945 68427 56011664
Complications of transplanted kidney 157.06 9.44 102 211874 2227 56077864
Pericarditis 155.61 9.44 110 211866 108813 55971278
Discomfort 155.20 9.44 183 211793 141578 55938513
Muscle injury 155.00 9.44 11 211965 52489 56027602
Lymphopenia 148.99 9.44 244 211732 16530 56063561
Acute graft versus host disease in skin 147.48 9.44 111 211865 3091 56077000
Epstein-Barr virus infection 146.43 9.44 160 211816 7303 56072788
Respiratory failure 144.94 9.44 725 211251 94337 55985754
BK virus infection 142.87 9.44 107 211869 2957 56077134
Blood urine present 140.97 9.44 212 211764 13343 56066748
Nocardiosis 136.41 9.44 85 211891 1723 56078368
Mucormycosis 136.36 9.44 100 211876 2674 56077417
Hospitalisation 134.32 9.44 57 211919 74943 56005148
Sleep disorder due to general medical condition, insomnia type 134.21 9.44 7 211969 43331 56036760
Cytomegalovirus infection reactivation 132.92 9.44 104 211872 3072 56077019
Neutrophil percentage increased 132.78 9.44 99 211877 2717 56077374
Post transplant lymphoproliferative disorder 131.87 9.44 122 211854 4550 56075541
Lymphocyte percentage decreased 131.59 9.44 99 211877 2755 56077336
Cushingoid 130.65 9.44 150 211826 7234 56072857
Graft versus host disease in gastrointestinal tract 129.01 9.44 99 211877 2840 56077251
Wrong technique in product usage process 127.51 9.44 31 211945 58137 56021954
Enterococcal infection 127.22 9.44 146 211830 7038 56073053
Urine analysis abnormal 127.04 9.44 120 211856 4597 56075494
Red cell distribution width increased 126.80 9.44 166 211810 9174 56070917
Folliculitis 125.11 9.44 27 211949 54952 56025139
Steroid diabetes 123.69 9.44 66 211910 985 56079106
Pseudomonas infection 121.50 9.44 169 211807 9902 56070189
Delayed graft function 119.52 9.44 63 211913 916 56079175
Graft versus host disease in skin 116.23 9.44 90 211886 2617 56077474
Duodenal ulcer perforation 116.04 9.44 56 211920 68286 56011805
Progressive multifocal leukoencephalopathy 115.25 9.44 181 211795 11832 56068259
Acute respiratory distress syndrome 111.82 9.44 252 211724 21674 56058417
Diarrhoea 110.37 9.44 1717 210259 636790 55443301
Injection site erythema 109.57 9.44 79 211897 77369 56002722
Anti-cyclic citrullinated peptide antibody positive 108.19 9.44 127 211849 98473 55981618
Klebsiella infection 107.09 9.44 139 211837 7617 56072474
Pain 103.56 9.44 1817 210159 661367 55418724
Varicella zoster virus infection 102.52 9.44 82 211894 2502 56077589
Helicobacter infection 102.01 9.44 76 211900 73192 56006899
Ear pruritus 101.69 9.44 86 211890 2842 56077249
Pneumomediastinum 101.32 9.44 63 211913 1272 56078819
Acute graft versus host disease in intestine 101.10 9.44 69 211907 1641 56078450
Bacterial test positive 100.07 9.44 108 211868 4860 56075231
Overdose 98.24 9.44 154 211822 105676 55974415
Device expulsion 97.27 9.44 4 211972 30445 56049646
Rheumatoid factor positive 96.97 9.44 71 211905 68989 56011102
Chest discomfort 96.81 9.44 671 211305 98186 55981905
Liver transplant rejection 96.08 9.44 61 211915 1279 56078812
Bacterial test 95.77 9.44 58 211918 1115 56078976
Urine ketone body present 95.52 9.44 76 211900 2301 56077790
Feeling hot 95.39 9.44 360 211616 41427 56038664
Pneumatosis intestinalis 95.35 9.44 74 211902 2159 56077932
Peripheral swelling 94.87 9.44 508 211468 234218 55845873
Suicide attempt 92.82 9.44 51 211925 57785 56022306
Psoriasis 91.75 9.44 129 211847 92563 55987528
Stomatitis 91.54 9.44 199 211777 120611 55959480
Adenovirus infection 88.55 9.44 85 211891 3323 56076768
Septic shock 88.50 9.44 458 211518 60377 56019714
Cardiac failure congestive 87.91 9.44 121 211855 87599 55992492
Human herpesvirus 6 infection 87.50 9.44 76 211900 2606 56077485
Reversible cerebral vasoconstriction syndrome 87.07 9.44 72 211904 2305 56077786
Fatigue 86.60 9.44 2286 209690 786266 55293825
Culture urine positive 86.06 9.44 85 211891 3443 56076648
Pyrexia 85.91 9.44 2123 209853 416650 55663441
Loss of personal independence in daily activities 85.88 9.44 108 211868 81261 55998830
Haemoglobin urine present 84.54 9.44 47 211929 764 56079327
Acute graft versus host disease 84.52 9.44 91 211885 4084 56076007
COVID-19 84.11 9.44 527 211449 74531 56005560
Osteonecrosis 82.88 9.44 233 211743 22982 56057109
Immunodeficiency 82.73 9.44 186 211790 15971 56064120
Acinetobacter infection 80.08 9.44 57 211919 1453 56078638
Lupus nephritis 80.00 9.44 73 211903 2674 56077417
Dehydration 79.39 9.44 318 211658 158507 55921584
Blood pressure diastolic increased 79.38 9.44 127 211849 8434 56071657
Temperature regulation disorder 77.76 9.44 90 211886 4378 56075713
Neutrophil count increased 76.31 9.44 172 211804 14793 56065298
Lower respiratory tract infection 75.96 9.44 203 211773 114591 55965500
Respiratory rate increased 75.52 9.44 152 211824 12085 56068006
Immunosuppressant drug level increased 74.98 9.44 76 211900 3177 56076914
Protein urine present 74.15 9.44 99 211877 5577 56074514
Vomiting 73.19 9.44 1379 210597 496849 55583242
Myopathy 71.77 9.44 131 211845 9681 56070410
Serotonin syndrome 71.59 9.44 8 211968 26482 56053609
Psoriatic arthropathy 71.27 9.44 105 211871 73903 56006188
Acute graft versus host disease in liver 70.15 9.44 39 211937 634 56079457
Pulmonary alveolar haemorrhage 69.41 9.44 83 211893 4181 56075910
Electric shock 69.08 9.44 46 211930 1049 56079042
Disseminated intravascular coagulation 68.31 9.44 184 211792 17701 56062390
Vasculitis 67.87 9.44 164 211812 14759 56065332
Accidental exposure to product 67.74 9.44 7 211969 24640 56055451
Encephalitis autoimmune 67.41 9.44 50 211926 1361 56078730
Escherichia infection 67.11 9.44 141 211835 11558 56068533
Viral haemorrhagic cystitis 66.69 9.44 40 211936 755 56079336
Drug resistance 66.43 9.44 199 211777 20343 56059748
Disease recurrence 66.01 9.44 219 211757 23641 56056450
Myocardial infarction 65.48 9.44 159 211817 92711 55987380
Hyponatraemia 65.05 9.44 184 211792 101955 55978136
Injection site swelling 64.90 9.44 42 211934 43536 56036555
Immune thrombocytopenia 64.78 9.44 124 211852 9501 56070590
Nephrotic syndrome 64.03 9.44 89 211887 5211 56074880
Gastrointestinal disorder 63.98 9.44 214 211762 112488 55967603
Multiple sclerosis 63.84 9.44 240 211736 27562 56052529
Specific gravity urine decreased 63.84 9.44 38 211938 707 56079384
Blister 63.72 9.44 204 211772 108683 55971408
Intervertebral discitis 63.64 9.44 65 211911 2742 56077349
Pneumonia cytomegaloviral 63.55 9.44 56 211920 1958 56078133
Cytomegalovirus colitis 63.45 9.44 57 211919 2045 56078046
Sepsis 63.43 9.44 805 211171 139035 55941056
Cytomegalovirus chorioretinitis 63.38 9.44 52 211924 1646 56078445
Adverse drug reaction 63.11 9.44 92 211884 65040 56015051
Enterobacter infection 62.65 9.44 56 211920 1996 56078095
Chorioretinopathy 62.39 9.44 39 211937 795 56079296
Impaired healing 61.76 9.44 148 211828 86693 55993398
Injection site pruritus 61.65 9.44 41 211935 41890 56038201
Knee arthroplasty 61.48 9.44 46 211930 44213 56035878
Orthostatic hypotension 61.43 9.44 24 211952 33175 56046916
Herpes simplex 60.95 9.44 105 211871 7413 56072678
Infective aneurysm 60.90 9.44 30 211946 375 56079716
Premature delivery 60.82 9.44 232 211744 26828 56053263
Epstein-Barr virus associated lymphoproliferative disorder 60.66 9.44 52 211924 1751 56078340
Leukopenia 60.53 9.44 466 211510 70474 56009617
Candida infection 60.13 9.44 223 211753 25444 56054647
Nitrite urine present 59.60 9.44 41 211935 988 56079103
Oedema peripheral 59.40 9.44 389 211587 170865 55909226
Systemic candida 59.32 9.44 65 211911 2976 56077115
Chronic graft versus host disease 59.05 9.44 67 211909 3189 56076902
Thrombocytopenia 58.76 9.44 777 211199 135447 55944644
Sedation 58.49 9.44 29 211947 34825 56045266
Rebound effect 57.60 9.44 72 211904 3798 56076293
Pharyngeal paraesthesia 57.46 9.44 49 211927 1638 56078453
Staphylococcal sepsis 57.45 9.44 101 211875 7248 56072843
Status epilepticus 57.05 9.44 155 211821 14986 56065105
Cystitis haemorrhagic 56.62 9.44 72 211904 3865 56076226
Cytokine release syndrome 56.58 9.44 126 211850 10749 56069342
Substance-induced psychotic disorder 56.15 9.44 49 211927 1691 56078400
Human herpesvirus 8 infection 56.09 9.44 24 211952 211 56079880
Hypoglycaemia 55.90 9.44 77 211899 55738 56024353
Blood thyroid stimulating hormone decreased 55.72 9.44 75 211901 4258 56075833
Plasma cell myeloma 55.67 9.44 56 211920 46590 56033501
Product quality issue 55.42 9.44 25 211951 31711 56048380
Intentional self-injury 55.39 9.44 13 211963 24979 56055112
Therapeutic product effect decreased 55.25 9.44 392 211584 169060 55911031
Monocyte percentage increased 54.75 9.44 40 211936 1063 56079028
Product use issue 54.69 9.44 443 211533 185598 55894493
Decreased appetite 54 9.44 546 211430 218685 55861406
General physical health deterioration 53.64 9.44 397 211579 169613 55910478
Strongyloidiasis 53.61 9.44 41 211935 1170 56078921
Nausea 53.33 9.44 2345 209631 761833 55318258
Systemic mycosis 53.05 9.44 40 211936 1117 56078974
Monocyte count increased 52.95 9.44 89 211887 6159 56073932
C-reactive protein abnormal 52.77 9.44 37 211939 36772 56043319
Body temperature decreased 52.60 9.44 169 211807 17939 56062152
Ureaplasma infection 52.11 9.44 30 211946 523 56079568
Anaphylactic shock 51.86 9.44 190 211786 21550 56058541
Tachycardia 51.68 9.44 618 211358 105258 55974833
Granulomatosis with polyangiitis 51.67 9.44 51 211925 2064 56078027
Constipation 51.38 9.44 499 211477 201444 55878647
Intentional product use issue 51.27 9.44 588 211388 99145 55980946
Osteonecrosis of jaw 51.26 9.44 31 211945 33327 56046764
Red blood cells urine 50.97 9.44 29 211947 494 56079597
Febrile bone marrow aplasia 50.95 9.44 90 211886 6482 56073609
Joint swelling 50.94 9.44 776 211200 289024 55791067
Serum sickness 50.72 9.44 56 211920 2586 56077505
COVID-19 pneumonia 50.48 9.44 122 211854 10980 56069111
Hypogammaglobulinaemia 49.82 9.44 88 211888 6338 56073753
Pleocytosis 49.66 9.44 32 211944 689 56079402
Optic neuritis 49.43 9.44 98 211878 7706 56072385
Thyroxine free increased 49.36 9.44 34 211942 821 56079270
Contusion 49.07 9.44 283 211693 128147 55951944
Syncope 48.92 9.44 225 211751 107974 55972117
Hepatic enzyme increased 48.59 9.44 412 211564 170972 55909119
Interstitial lung disease 47.65 9.44 373 211603 56690 56023401
Cerebrovascular accident 47.56 9.44 202 211774 99068 55981023
Urticaria 47.04 9.44 786 211190 143890 55936201
Central nervous system viral infection 46.87 9.44 17 211959 91 56080000
Therapy cessation 46.79 9.44 22 211954 27242 56052849
Therapy interrupted 46.63 9.44 19 211957 25606 56054485
Adverse event 46.39 9.44 86 211890 55290 56024801
Injection site bruising 46.25 9.44 46 211930 38475 56041616
Macular degeneration 45.72 9.44 8 211968 18900 56061191
Pulmonary mucormycosis 44.91 9.44 21 211955 232 56079859
Pedal pulse abnormal 44.81 9.44 19 211957 163 56079928
Feeding intolerance 44.65 9.44 28 211948 574 56079517
Intensive care unit acquired weakness 44.60 9.44 30 211946 696 56079395
Intra-abdominal pressure increased 44.60 9.44 20 211956 199 56079892
Food allergy 44.52 9.44 101 211875 8723 56071368
Poor venous access 44.40 9.44 124 211852 12182 56067909
Hypertension 44.30 9.44 1219 210757 243059 55837032
Listeriosis 44.08 9.44 39 211937 1371 56078720
Demyelination 43.79 9.44 82 211894 6180 56073911
Bacteraemia 43.71 9.44 144 211832 15487 56064604
Mean cell haemoglobin decreased 43.51 9.44 67 211909 4305 56075786
Drug hypersensitivity 43.35 9.44 752 211224 274453 55805638
Malignant neoplasm progression 42.94 9.44 138 211838 73449 56006642
Dizziness 42.74 9.44 1084 210892 375056 55705035
Blood calcium decreased 42.65 9.44 18 211958 23751 56056340
Injection site reaction 42.59 9.44 85 211891 53162 56026929
Surgery 42.31 9.44 36 211940 32450 56047641
Segmental diverticular colitis 42.29 9.44 18 211958 156 56079935
Proteinuria 42.29 9.44 154 211822 17416 56062675
Intentional product misuse 42.25 9.44 81 211895 51423 56028668
West Nile viral infection 42.25 9.44 23 211953 358 56079733
Colitis ulcerative 42.19 9.44 193 211783 24198 56055893
Hip arthroplasty 42.08 9.44 50 211926 38573 56041518
JC virus infection 41.11 9.44 43 211933 1866 56078225
International normalised ratio increased 40.93 9.44 64 211912 43977 56036114
Toxoplasmosis 40.92 9.44 38 211938 1424 56078667
Hepatocellular injury 40.92 9.44 203 211773 26311 56053780
Mycoplasma infection 40.49 9.44 24 211952 443 56079648
Bone pain 40.24 9.44 80 211896 50105 56029986
Drug interaction 40.21 9.44 552 211424 209203 55870888
Encephalitis 40.16 9.44 92 211884 7998 56072093
Neuromyelitis optica spectrum disorder 39.89 9.44 33 211943 1057 56079034
Red blood cell count increased 39.88 9.44 52 211924 2862 56077229
Human bocavirus infection 39.72 9.44 22 211954 355 56079736
Herpes zoster 39.71 9.44 449 211527 75440 56004651
Central nervous system infection 39.64 9.44 28 211948 705 56079386
Pneumatosis 39.60 9.44 23 211953 408 56079683
Systemic inflammatory response syndrome 39.28 9.44 71 211905 5207 56074884
Accidental overdose 39.18 9.44 14 211962 20447 56059644
Pregnancy 39.03 9.44 40 211936 32993 56047098
Red blood cell sedimentation rate abnormal 38.92 9.44 11 211965 18662 56061429
Encephalitis cytomegalovirus 38.85 9.44 25 211951 537 56079554
Calcium ionised decreased 38.36 9.44 20 211956 284 56079807
Infection reactivation 38.26 9.44 32 211944 1041 56079050
Candida sepsis 38.24 9.44 35 211941 1287 56078804
Stenotrophomonas infection 38.14 9.44 40 211936 1741 56078350
Coeliac disease 38.12 9.44 105 211871 10234 56069857
Dermatomyositis 37.92 9.44 49 211927 2673 56077418
Device issue 37.84 9.44 16 211960 21090 56059001
Necrotising herpetic retinopathy 37.55 9.44 14 211962 82 56080009
Haemolytic anaemia 37.35 9.44 100 211876 9585 56070506
Adrenal insufficiency 37.29 9.44 137 211839 15560 56064531
Depressed level of consciousness 37.16 9.44 100 211876 56333 56023758
Mycobacterium abscessus infection 36.96 9.44 26 211950 650 56079441
Hyperglycaemia 36.95 9.44 259 211717 38022 56042069
Chronic allograft nephropathy 36.93 9.44 26 211950 651 56079440
Hypofibrinogenaemia 36.65 9.44 32 211944 1105 56078986
Device malfunction 36.55 9.44 8 211968 16128 56063963
Breast cancer 36.50 9.44 81 211895 48752 56031339
Swollen joint count increased 36.43 9.44 23 211953 24161 56055930
Laryngeal stenosis 36.28 9.44 29 211947 884 56079207
Bronchospasm 35.75 9.44 135 211841 15534 56064557
Lower limb fracture 35.70 9.44 11 211965 17644 56062447
C-reactive protein increased 35.67 9.44 453 211523 78231 56001860
Cells in urine 35.49 9.44 17 211959 199 56079892
Full blood count decreased 35.46 9.44 22 211954 23327 56056764
Mobility decreased 35.25 9.44 223 211753 98768 55981323
Choroiditis 35.01 9.44 16 211960 167 56079924
Product prescribing error 35.00 9.44 22 211954 23164 56056927
Symptom masked 34.89 9.44 25 211951 644 56079447
Rash erythematous 34.86 9.44 250 211726 36971 56043120
Cerebral aspergillosis 34.80 9.44 21 211955 401 56079690
Glomerulonephritis 34.62 9.44 37 211939 1646 56078445
Breast cancer metastatic 34.37 9.44 8 211968 15461 56064630
Cataract 34.35 9.44 319 211657 50928 56029163
Rhabdomyolysis 34.18 9.44 63 211913 40595 56039496
Pancytopenia 34.16 9.44 496 211480 88219 55991872
Engraftment syndrome 34.12 9.44 21 211955 416 56079675
Vaginal flatulence 34.10 9.44 25 211951 668 56079423
Urine leukocyte esterase 34.10 9.44 15 211961 142 56079949
Oral pruritus 34.05 9.44 38 211938 1776 56078315
Band sensation 34.02 9.44 26 211950 741 56079350
Nephropathy toxic 33.85 9.44 89 211887 8438 56071653
Gastroenteritis norovirus 33.65 9.44 38 211938 1799 56078292
Drug effective for unapproved indication 33.62 9.44 45 211931 2541 56077550
Partial seizures 33.32 9.44 67 211909 5323 56074768
Hepatitis 33.16 9.44 238 211738 35203 56044888
Epstein-Barr virus infection reactivation 33.04 9.44 24 211952 632 56079459
Haemolytic uraemic syndrome 33.00 9.44 43 211933 2365 56077726
Transient ischaemic attack 32.94 9.44 47 211929 33530 56046561
Urinary casts 32.94 9.44 25 211951 705 56079386
Sleep disorder 32.82 9.44 137 211839 67526 56012565
Disseminated tuberculosis 32.53 9.44 46 211930 2737 56077354
Secondary immunodeficiency 32.35 9.44 31 211945 1209 56078882
Drug ineffective 32.32 9.44 3940 208036 915049 55165042
Osteoarthritis 32.26 9.44 174 211802 80122 55999969
Neuroleptic malignant syndrome 32.22 9.44 3 211973 11475 56068616
Steroid dependence 32.15 9.44 21 211955 463 56079628
Gastrooesophageal reflux disease 32.04 9.44 183 211793 83074 55997017
Blood immunoglobulin M decreased 31.96 9.44 26 211950 813 56079278
Hypophagia 31.86 9.44 37 211939 28839 56051252
Diffuse large B-cell lymphoma 31.79 9.44 77 211899 6939 56073152
Renal transplant failure 31.71 9.44 24 211952 674 56079417
Herpes virus infection 31.64 9.44 64 211912 5106 56074985
Shock haemorrhagic 31.59 9.44 90 211886 8943 56071148
Thunderclap headache 31.59 9.44 15 211961 172 56079919
Aplasia 31.34 9.44 55 211921 3941 56076150
Hepatic function abnormal 31.15 9.44 230 211746 34328 56045763
Oral herpes 31.00 9.44 169 211807 22721 56057370
Temperature intolerance 30.99 9.44 83 211893 7957 56072134
Myelitis 30.97 9.44 31 211945 1276 56078815
Graft versus host disease in liver 30.82 9.44 21 211955 498 56079593
Diabetes mellitus 30.82 9.44 319 211657 52416 56027675
Memory impairment 30.81 9.44 195 211781 86362 55993729
Rash 30.45 9.44 1532 210444 491515 55588576
Injection site warmth 30.42 9.44 8 211968 14235 56065856
Pyelonephritis fungal 30.31 9.44 13 211963 115 56079976
Immunosuppressant drug level decreased 30.22 9.44 26 211950 880 56079211
Brain abscess 30.20 9.44 37 211939 1912 56078179
Rheumatoid arthritis 30.17 9.44 1157 210819 381447 55698644
Monocyte count decreased 30.03 9.44 37 211939 1923 56078168
Central nervous system lymphoma 29.95 9.44 33 211943 1520 56078571
Suicidal ideation 29.85 9.44 114 211862 57628 56022463
Intestinal perforation 29.79 9.44 100 211876 10859 56069232
Cytomegalovirus enterocolitis 29.78 9.44 22 211954 595 56079496
Poisoning 29.75 9.44 6 211970 12807 56067284
Device difficult to use 29.72 9.44 3 211973 10758 56069333
Cough 29.67 9.44 1229 210747 258732 55821359
Incorrect dose administered 29.65 9.44 100 211876 52447 56027644
Pain in extremity 29.64 9.44 873 211103 296558 55783533
Smear cervix abnormal 29.64 9.44 44 211932 2737 56077354
Gastroenteritis rotavirus 29.47 9.44 13 211963 124 56079967
Abdominal pain upper 29.43 9.44 483 211493 177830 55902261
Product storage error 29.03 9.44 7 211969 13206 56066885
Mean cell volume decreased 28.86 9.44 49 211927 3419 56076672
Neuralgia 28.83 9.44 170 211806 23525 56056566
Acute myeloid leukaemia recurrent 28.66 9.44 32 211944 1496 56078595
Unresponsive to stimuli 28.63 9.44 47 211929 31678 56048413
Opportunistic infection 28.49 9.44 34 211942 1709 56078382
Band neutrophil percentage increased 28.40 9.44 15 211961 219 56079872
Infection 28.39 9.44 557 211419 199649 55880442
Treatment failure 28.30 9.44 461 211515 169931 55910160
Chills 28.22 9.44 543 211433 102061 55978030
Aspergillosis oral 28.13 9.44 10 211966 50 56080041
Staphylococcal bacteraemia 27.83 9.44 61 211915 5148 56074943
Multiple-drug resistance 27.74 9.44 52 211924 3922 56076169
Dural arteriovenous fistula 27.63 9.44 8 211968 17 56080074
Blood thyroid stimulating hormone increased 27.60 9.44 70 211906 6493 56073598
Quadriparesis 27.55 9.44 34 211942 1770 56078321
Herpes simplex colitis 27.51 9.44 6 211970 0 56080091
Oropharyngeal pain 27.50 9.44 456 211520 83332 55996759
CSF protein increased 27.40 9.44 19 211957 464 56079627
Bacterial sepsis 27.35 9.44 50 211926 3699 56076392
Glomerulosclerosis 27.35 9.44 17 211959 343 56079748
Diffuse alveolar damage 27.31 9.44 24 211952 836 56079255
Transplant failure 27.28 9.44 31 211945 1478 56078613
Pulmonary haemorrhage 27.13 9.44 71 211905 6712 56073379
Oral candidiasis 27.09 9.44 141 211835 18622 56061469
Mean cell haemoglobin concentration increased 27.01 9.44 19 211957 475 56079616
Full blood count abnormal 27.00 9.44 36 211940 26426 56053665
Respiratory distress 26.99 9.44 208 211768 31459 56048632
Pharyngeal dyskinesia 26.92 9.44 9 211967 36 56080055
Haemoglobin urine 26.88 9.44 12 211964 118 56079973
Bacillus infection 26.85 9.44 22 211954 695 56079396
Throat tightness 26.77 9.44 160 211816 22247 56057844
Leukoencephalopathy 26.75 9.44 52 211924 4030 56076061
Unevaluable event 26.74 9.44 91 211885 47596 56032495
Listeria encephalitis 26.70 9.44 15 211961 249 56079842
Injection site mass 26.66 9.44 15 211961 16778 56063313
Staphylococcal infection 26.65 9.44 237 211739 37381 56042710
Alveolitis 26.65 9.44 41 211935 2632 56077459
Escherichia sepsis 26.63 9.44 55 211921 4454 56075637
Body temperature fluctuation 26.58 9.44 36 211940 2056 56078035
Pulmonary hypertension 26.55 9.44 60 211916 35884 56044207
Endocrine ophthalmopathy 26.53 9.44 19 211957 489 56079602
Coronary artery disease 26.53 9.44 47 211929 30749 56049342
Lip pruritus 26.44 9.44 23 211953 790 56079301
Q fever 26.39 9.44 11 211965 90 56080001
Lethargy 26.31 9.44 102 211874 51339 56028752
Blood albumin increased 26.19 9.44 24 211952 884 56079207
Injection site haemorrhage 26.09 9.44 27 211949 22174 56057917
Tri-iodothyronine free increased 26.06 9.44 14 211962 212 56079879
IgA nephropathy 25.72 9.44 19 211957 514 56079577
Immune effector cell-associated neurotoxicity syndrome 25.68 9.44 31 211945 1577 56078514
Perinephric abscess 25.67 9.44 13 211963 173 56079918
Underdose 25.61 9.44 31 211945 23726 56056365
Viraemia 25.49 9.44 26 211950 1095 56078996
Necrotising retinitis 25.40 9.44 17 211959 391 56079700
Steroid withdrawal syndrome 25.37 9.44 19 211957 525 56079566
Quadriplegia 25.33 9.44 32 211944 1706 56078385
Drug level decreased 25.31 9.44 71 211905 6993 56073098
Chronic graft versus host disease in liver 25.30 9.44 15 211961 277 56079814
Malignant catatonia 25.22 9.44 13 211963 180 56079911
Leukocyturia 25.22 9.44 26 211950 1109 56078982
Arterial occlusive disease 25.19 9.44 60 211916 5350 56074741
Engraft failure 25.05 9.44 16 211960 339 56079752
Anti-thyroid antibody positive 24.99 9.44 17 211959 402 56079689
Urobilinogen urine increased 24.92 9.44 15 211961 285 56079806
Neuropsychiatric lupus 24.91 9.44 13 211963 185 56079906
Device dislocation 24.91 9.44 29 211947 22577 56057514
White blood cell count increased 24.86 9.44 268 211708 44491 56035600
Skin fissures 24.83 9.44 86 211890 9487 56070604
Blood creatinine decreased 24.82 9.44 58 211918 5108 56074983
Mean cell haemoglobin concentration decreased 24.81 9.44 44 211932 3179 56076912
Torsade de pointes 24.71 9.44 8 211968 12432 56067659
Sense of oppression 24.69 9.44 24 211952 953 56079138
Escherichia urinary tract infection 24.58 9.44 94 211882 10881 56069210
Anorectal ulcer 24.54 9.44 9 211967 50 56080041
Polyomavirus viraemia 24.46 9.44 18 211958 484 56079607
Chronic graft versus host disease in skin 24.45 9.44 21 211955 709 56079382
Cerebral artery stenosis 24.41 9.44 17 211959 418 56079673
Breast cancer female 24.39 9.44 8 211968 12330 56067761
Cerebellar stroke 24.37 9.44 14 211962 243 56079848
Abscess 24.37 9.44 117 211859 14964 56065127
Drug tolerance decreased 24.31 9.44 10 211966 13401 56066690
Natural killer-cell leukaemia 24.31 9.44 11 211965 112 56079979
Faecal volume decreased 24.22 9.44 12 211964 152 56079939
Specific gravity urine increased 24.19 9.44 13 211963 197 56079894
Non-consummation 24.10 9.44 9 211967 53 56080038
Factor XIII deficiency 24.08 9.44 10 211966 81 56080010
Joint tuberculosis 24.05 9.44 11 211965 115 56079976
Injection site urticaria 24.05 9.44 9 211967 12774 56067317
Acute pulmonary oedema 24.00 9.44 73 211903 7524 56072567
Enterococcus test positive 23.97 9.44 25 211951 1081 56079010
Malacoplakia vesicae 23.82 9.44 9 211967 55 56080036
Parvovirus B19 infection 23.58 9.44 18 211958 512 56079579
CSF oligoclonal band present 23.54 9.44 14 211962 260 56079831
Birdshot chorioretinopathy 23.46 9.44 10 211966 87 56080004
Pain in jaw 23.41 9.44 75 211901 39961 56040130
Urinary tract candidiasis 23.38 9.44 18 211958 519 56079572
Inappropriate schedule of product administration 23.37 9.44 201 211775 83186 55996905
Type I hypersensitivity 23.30 9.44 37 211939 2441 56077650
Pneumocystis jirovecii infection 23.30 9.44 27 211949 1315 56078776
Magnetic resonance imaging abnormal 23.20 9.44 40 211936 2826 56077265
Liver function test abnormal 23.07 9.44 91 211885 45580 56034511
Injection site rash 23.07 9.44 18 211958 16940 56063151
Cestode infection 22.94 9.44 14 211962 273 56079818
Pyelonephritis 22.85 9.44 120 211856 15904 56064187
Mean cell haemoglobin increased 22.80 9.44 36 211940 2364 56077727
Rubella antibody positive 22.79 9.44 9 211967 63 56080028
Right ventricular failure 22.77 9.44 17 211959 16362 56063729
Needle issue 22.72 9.44 3 211973 8735 56071356
Creatinine urine decreased 22.67 9.44 12 211964 176 56079915
Orbital apex syndrome 22.67 9.44 8 211968 39 56080052
Bacterial vulvovaginitis 22.65 9.44 20 211956 701 56079390
Eosinophil percentage increased 22.31 9.44 23 211953 981 56079110
Encephalopathy 22.24 9.44 217 211759 35108 56044983
Corynebacterium infection 22.23 9.44 17 211959 485 56079606
Schizophrenia 22.23 9.44 6 211970 10493 56069598
Cytomegalovirus enteritis 22.22 9.44 13 211963 234 56079857
Aphthous ulcer 22.21 9.44 97 211879 11922 56068169
Renal tubular atrophy 22.18 9.44 20 211956 721 56079370
Hyperammonaemia 22.15 9.44 54 211922 4886 56075205
Band neutrophil count increased 22.00 9.44 15 211961 356 56079735
Rhinocerebral mucormycosis 21.87 9.44 14 211962 298 56079793
Epstein-Barr virus associated lymphoma 21.85 9.44 17 211959 498 56079593
Product substitution issue 21.83 9.44 14 211962 14585 56065506
Muir-Torre syndrome 21.77 9.44 7 211969 24 56080067
Lichen sclerosus 21.71 9.44 23 211953 1013 56079078
Hypertransaminasaemia 21.69 9.44 52 211924 4655 56075436
Ulcer 21.62 9.44 152 211824 22333 56057758
Tri-iodothyronine free decreased 21.58 9.44 14 211962 305 56079786
Blood glucose decreased 21.56 9.44 24 211952 19063 56061028
Perforation 21.53 9.44 23 211953 1023 56079068
Bone marrow failure 21.50 9.44 181 211795 28105 56051986
Myelopathy 21.49 9.44 37 211939 2611 56077480
Cerebral venous thrombosis 21.45 9.44 31 211945 1882 56078209
Muscular weakness 21.44 9.44 530 211446 103922 55976169
Central obesity 21.41 9.44 24 211952 1127 56078964
Metastases to liver 21.39 9.44 30 211946 21556 56058535
Focal segmental glomerulosclerosis 21.38 9.44 27 211949 1439 56078652
Central nervous system lesion 21.35 9.44 84 211892 9854 56070237
Autoimmune hepatitis 21.28 9.44 72 211904 7849 56072242
Acute kidney injury 21.23 9.44 718 211258 240045 55840046
Gangrene 21.16 9.44 57 211919 5483 56074608
Haematocrit decreased 21.15 9.44 222 211754 36607 56043484
Disseminated varicella zoster vaccine virus infection 21.03 9.44 8 211968 50 56080041
Product complaint 20.95 9.44 9 211967 11751 56068340
Neurosarcoidosis 20.91 9.44 12 211964 208 56079883
Post-traumatic stress disorder 20.77 9.44 50 211926 4488 56075603
Muscle spasms 20.75 9.44 378 211598 136993 55943098
Femur fracture 20.69 9.44 77 211899 39218 56040873
Therapeutic product effect incomplete 20.67 9.44 278 211698 105753 55974338
Osteomyelitis fungal 20.65 9.44 6 211970 13 56080078
Clostridium difficile colitis 20.62 9.44 131 211845 18607 56061484
Herpes simplex oesophagitis 20.51 9.44 11 211965 166 56079925
Coma 20.41 9.44 136 211840 59519 56020572
Thrombotic thrombocytopenic purpura 20.40 9.44 44 211932 3673 56076418
Shock 20.38 9.44 146 211830 21582 56058509
Rhesus antigen positive 20.37 9.44 10 211966 124 56079967
Fungaemia 20.37 9.44 32 211944 2092 56077999
Tardive dyskinesia 20.31 9.44 3 211973 8028 56072063
Nightmare 20.30 9.44 20 211956 16806 56063285
Ultrasound ovary abnormal 20.29 9.44 9 211967 87 56080004
Hepatic infarction 20.29 9.44 18 211958 635 56079456
Pathogen resistance 20.23 9.44 59 211917 5941 56074150
Product dispensing error 20.17 9.44 5 211971 9259 56070832
Oedema 20.15 9.44 204 211772 81716 55998375
Sinusitis 20.14 9.44 578 211398 197003 55883088
CSF measles antibody positive 20.14 9.44 8 211968 57 56080034
Drug withdrawal syndrome 20.06 9.44 42 211934 25815 56054276
Dementia 20.01 9.44 21 211955 17137 56062954
Graft versus host disease in lung 20.01 9.44 14 211962 347 56079744
Immunoglobulins decreased 19.95 9.44 23 211953 1114 56078977
Body temperature increased 19.94 9.44 207 211769 34035 56046056
Paralysis 19.93 9.44 77 211899 8955 56071136
Drug-induced liver injury 19.91 9.44 208 211768 34254 56045837
Biloma 19.91 9.44 8 211968 59 56080032
Treatment noncompliance 19.86 9.44 60 211916 32563 56047528
Blood brain barrier defect 19.86 9.44 9 211967 92 56079999
Hepatitis toxic 19.83 9.44 38 211938 2914 56077177
Hypersensitivity 19.82 9.44 777 211199 255631 55824460
Cryptococcosis 19.78 9.44 22 211954 1024 56079067
Proctitis 19.77 9.44 35 211941 2525 56077566
Coordination abnormal 19.74 9.44 97 211879 12524 56067567
Cytomegalovirus gastrointestinal infection 19.73 9.44 13 211963 291 56079800
Myelocyte count increased 19.70 9.44 14 211962 356 56079735
Blood immunoglobulin G decreased 19.68 9.44 32 211944 2154 56077937
Antinuclear antibody 19.68 9.44 16 211960 500 56079591
Peritonitis 19.55 9.44 116 211860 16086 56064005
Hypotension 19.49 9.44 1141 210835 249367 55830724
Haemorrhagic varicella syndrome 19.48 9.44 5 211971 5 56080086
Toxic epidermal necrolysis 19.46 9.44 146 211830 21896 56058195
Klebsiella test positive 19.42 9.44 21 211955 947 56079144
Premenstrual syndrome 19.39 9.44 18 211958 674 56079417
Capillary leak syndrome 19.38 9.44 30 211946 1936 56078155
Meningoencephalitis viral 19.35 9.44 13 211963 301 56079790
Neuropathy peripheral 19.26 9.44 272 211704 102621 55977470
B-lymphocyte count decreased 19.24 9.44 21 211955 957 56079134
Urine oxalate increased 19.22 9.44 12 211964 244 56079847
Pulmonary nocardiosis 19.20 9.44 11 211965 190 56079901
Meningoencephalitis bacterial 19.14 9.44 8 211968 66 56080025
Microscopic polyangiitis 19.10 9.44 11 211965 192 56079899
Therapy non-responder 19.07 9.44 331 211645 61024 56019067
Serratia infection 18.99 9.44 20 211956 875 56079216
Vein collapse 18.97 9.44 20 211956 876 56079215
Heart transplant rejection 18.91 9.44 15 211961 452 56079639
Acute respiratory failure 18.83 9.44 189 211787 30805 56049286
Meningomyelitis herpes 18.79 9.44 6 211970 20 56080071
Biliary anastomosis complication 18.78 9.44 7 211969 41 56080050
Necrosis ischaemic 18.63 9.44 19 211957 800 56079291
Hepatic necrosis 18.62 9.44 53 211923 5263 56074828
Anaphylactic reaction 18.60 9.44 319 211657 58676 56021415
Hepatic cyst infection 18.59 9.44 9 211967 108 56079983
Myelocyte percentage increased 18.56 9.44 11 211965 203 56079888
Therapy partial responder 18.53 9.44 68 211908 7717 56072374
Hypertriglyceridaemia 18.48 9.44 56 211920 5760 56074331
Hypoproteinaemia 18.42 9.44 29 211947 1899 56078192
Type 1 diabetes mellitus 18.42 9.44 40 211936 3354 56076737
Emphysematous pyelonephritis 18.42 9.44 11 211965 206 56079885
Crystalluria 18.38 9.44 14 211962 397 56079694
Haemodynamic instability 18.38 9.44 71 211905 8258 56071833
Complications of transplant surgery 18.35 9.44 10 211966 156 56079935
Rheumatic fever 18.29 9.44 52 211924 28775 56051316
Enthesopathy 18.26 9.44 4 211972 8059 56072032
Neurological decompensation 18.25 9.44 33 211943 2421 56077670
Kaposi's sarcoma 18.24 9.44 10 211966 158 56079933
Pneumonia bacterial 18.18 9.44 69 211907 7959 56072132
Sleep apnoea syndrome 18.06 9.44 45 211931 26016 56054075
Gastropleural fistula 17.98 9.44 7 211969 47 56080044
Sensory loss 17.97 9.44 74 211902 8861 56071230
Relapsing-remitting multiple sclerosis 17.95 9.44 16 211960 568 56079523
Proteus infection 17.93 9.44 19 211957 837 56079254
Hallucination 17.86 9.44 110 211866 49039 56031052
Butterfly rash 17.76 9.44 25 211951 1481 56078610
Gastrointestinal mucormycosis 17.69 9.44 11 211965 222 56079869
Tuberculosis gastrointestinal 17.68 9.44 13 211963 349 56079742
Complication associated with device 17.67 9.44 19 211957 15331 56064760
Atrial fibrillation 17.61 9.44 296 211680 108601 55971490
Normal newborn 17.58 9.44 65 211911 7405 56072686
Red cell distribution width decreased 17.56 9.44 26 211950 1613 56078478
Metastases to bone 17.51 9.44 29 211947 19479 56060612
Prescribed overdose 17.48 9.44 36 211940 22260 56057831
Bilirubin urine present 17.46 9.44 8 211968 84 56080007
Pulmonary arterial hypertension 17.42 9.44 47 211929 26456 56053635
Diverticulum 17.40 9.44 10 211966 11056 56069035
Pyomyositis 17.40 9.44 13 211963 358 56079733
Adrenal atrophy 17.39 9.44 6 211970 27 56080064
Breast cancer stage III 17.39 9.44 3 211973 7160 56072931
Meningitis chemical 17.37 9.44 9 211967 126 56079965
Mucous stools 17.37 9.44 39 211937 3345 56076746
Conjunctivitis 17.31 9.44 122 211854 17938 56062153
Pneumonia lipoid 17.31 9.44 9 211967 127 56079964
Sebaceous carcinoma 17.21 9.44 6 211970 28 56080063
Microangiopathy 17.20 9.44 21 211955 1081 56079010
Allergy to chemicals 17.19 9.44 32 211944 2401 56077690
Heart rate irregular 17.16 9.44 135 211841 20544 56059547
Fusarium infection 17.15 9.44 16 211960 603 56079488
Monoparesis 17.13 9.44 25 211951 1531 56078560
Thrombocytopenic purpura 17.12 9.44 23 211953 1303 56078788
Loss of consciousness 17.11 9.44 299 211677 109050 55971041
Blood loss anaemia 17.08 9.44 5 211971 8292 56071799
Menstruation irregular 17.06 9.44 58 211918 6338 56073753
Histoplasmosis disseminated 17.04 9.44 23 211953 1309 56078782
Pseudomonal sepsis 17.03 9.44 30 211946 2156 56077935
Granuloma skin 17.01 9.44 3 211973 7048 56073043
Renal impairment 16.99 9.44 411 211565 80302 55999789
Eosinophilic granulomatosis with polyangiitis 16.99 9.44 29 211947 2032 56078059
Liver abscess 16.99 9.44 34 211942 2692 56077399
Abortion spontaneous 16.92 9.44 96 211880 43657 56036434
Swollen tongue 16.91 9.44 58 211918 30266 56049825
Rhodococcus infection 16.90 9.44 8 211968 91 56080000
Urinary tract infection bacterial 16.89 9.44 46 211930 4454 56075637
Medication error 16.85 9.44 92 211884 42243 56037848
Bradycardia 16.80 9.44 352 211624 67152 56012939
Renal tubular necrosis 16.77 9.44 83 211893 10745 56069346
Thrombosis 16.76 9.44 143 211833 59284 56020807
Anal erythema 16.75 9.44 10 211966 187 56079904
Coronavirus infection 16.68 9.44 38 211938 3291 56076800
Infective pulmonary exacerbation of cystic fibrosis 16.64 9.44 5 211971 8152 56071939
Gastrointestinal mucosa hyperaemia 16.61 9.44 10 211966 190 56079901
Dysmenorrhoea 16.60 9.44 39 211937 3447 56076644
Bacterial infection 16.57 9.44 117 211859 17213 56062878
Ureteral disorder 16.52 9.44 12 211964 316 56079775
Vaginal haemorrhage 16.52 9.44 46 211930 25627 56054464
Lip dry 16.50 9.44 8 211968 9732 56070359
CD4 lymphocytes decreased 16.47 9.44 23 211953 1352 56078739
Eosinophil count increased 16.47 9.44 76 211900 9561 56070530
Thyroid stimulating immunoglobulin 16.32 9.44 7 211969 62 56080029
Malacoplakia gastrointestinal 16.32 9.44 7 211969 62 56080029
Granulocyte count increased 16.31 9.44 15 211961 555 56079536
Joint effusion 16.30 9.44 104 211872 14794 56065297
Premature baby 16.28 9.44 126 211850 19079 56061012
Allergy test positive 16.24 9.44 13 211963 397 56079694
Central nervous system lupus 16.16 9.44 13 211963 400 56079691
Labelled drug-drug interaction medication error 16.14 9.44 12 211964 11574 56068517
Renal vein thrombosis 16.10 9.44 12 211964 329 56079762
Asymptomatic bacteriuria 16.10 9.44 11 211965 262 56079829
Paraparesis 16.07 9.44 29 211947 2124 56077967
Scleritis 16.04 9.44 40 211936 3671 56076420
Central nervous system vasculitis 16.01 9.44 18 211958 848 56079243
Brain oedema 16.00 9.44 95 211881 13176 56066915
Cytopenia 15.99 9.44 76 211900 9679 56070412
Acute disseminated encephalomyelitis 15.99 9.44 10 211966 204 56079887
Female genital tract fistula 15.95 9.44 45 211931 4447 56075644
Autoimmune thyroiditis 15.93 9.44 39 211937 3539 56076552
Growth retardation 15.85 9.44 21 211955 1174 56078917
Colitis 15.79 9.44 233 211743 41578 56038513
Multiple allergies 15.78 9.44 10 211966 10486 56069605
Blindness cortical 15.76 9.44 14 211962 495 56079596
Colitis microscopic 15.76 9.44 5 211971 7870 56072221
Lymphocyte count increased 15.70 9.44 36 211940 3131 56076960
Chronic graft versus host disease in eye 15.70 9.44 8 211968 108 56079983
Globulins decreased 15.70 9.44 10 211966 211 56079880
Dysphagia 15.69 9.44 412 211564 81535 55998556
Sensitivity to weather change 15.67 9.44 3 211973 6646 56073445
Vaginal discharge 15.67 9.44 55 211921 6108 56073983
Hairy cell leukaemia 15.67 9.44 7 211969 69 56080022
Tubulointerstitial nephritis 15.64 9.44 112 211864 16553 56063538
Basal cell carcinoma 15.63 9.44 46 211930 25175 56054916
Night sweats 15.63 9.44 91 211885 41122 56038969
Immune reconstitution inflammatory syndrome 15.62 9.44 52 211924 5622 56074469
Sinus bradycardia 15.59 9.44 96 211880 13490 56066601
Tenosynovitis stenosans 15.57 9.44 32 211944 2582 56077509
Blood parathyroid hormone decreased 15.55 9.44 6 211970 8358 56071733
JC polyomavirus test positive 15.54 9.44 21 211955 1197 56078894
Lung abscess 15.50 9.44 25 211951 1671 56078420
Hepatic haemorrhage 15.45 9.44 14 211962 508 56079583
Lymphocele 15.38 9.44 17 211959 786 56079305
White blood cells urine 15.38 9.44 12 211964 353 56079738
Transient hypogammaglobulinaemia of infancy 15.32 9.44 6 211970 41 56080050
Hepatic cirrhosis 15.30 9.44 36 211940 21227 56058864
Oesophageal candidiasis 15.28 9.44 49 211927 5196 56074895
Dry throat 15.26 9.44 54 211922 6020 56074071
Encephalitis brain stem 15.26 9.44 8 211968 115 56079976
Fibromyalgia 15.25 9.44 147 211829 59456 56020635
Venoocclusive disease 15.23 9.44 27 211949 1950 56078141
Obstructive airways disorder 15.23 9.44 26 211950 17256 56062835
Uterine perforation 15.20 9.44 3 211973 6502 56073589
Low birth weight baby 15.18 9.44 55 211921 6203 56073888
Gastroduodenal ulcer 15.14 9.44 9 211967 167 56079924
Allergy to plants 15.14 9.44 15 211961 610 56079481
Gamma-glutamyltransferase increased 15.12 9.44 181 211795 30824 56049267
Injection site extravasation 15.08 9.44 66 211910 8118 56071973
Pulmonary tuberculosis 15.08 9.44 44 211932 4432 56075659
Magnesium deficiency 15.02 9.44 14 211962 527 56079564
Aspergilloma 15.00 9.44 9 211967 170 56079921
Interleukin-2 receptor increased 15.00 9.44 7 211969 77 56080014
Nasal septum disorder 14.96 9.44 8 211968 120 56079971
Thyroid stimulating immunoglobulin increased 14.92 9.44 7 211969 78 56080013
Nodular regenerative hyperplasia 14.89 9.44 13 211963 449 56079642
Malaise 14.85 9.44 1188 210788 366672 55713419
Encephalitis Japanese B 14.84 9.44 6 211970 45 56080046
Aeromonas infection 14.84 9.44 7 211969 79 56080012
Myasthenia gravis crisis 14.81 9.44 13 211963 452 56079639
Neoplasm progression 14.80 9.44 66 211910 31950 56048141
Papilloma viral infection 14.80 9.44 22 211954 1370 56078721
Blood pressure systolic decreased 14.76 9.44 55 211921 6288 56073803
pH urine increased 14.73 9.44 12 211964 376 56079715
Intestine transplant rejection 14.73 9.44 6 211970 46 56080045
Diabetic macroangiopathy 14.73 9.44 8 211968 124 56079967
Dystonia 14.72 9.44 15 211961 12406 56067685
Lipaemic index score 14.68 9.44 7 211969 81 56080010
Hyperthermia 14.65 9.44 66 211910 8219 56071872
Angiocentric lymphoma 14.64 9.44 15 211961 635 56079456
Hysterectomy 14.64 9.44 7 211969 8584 56071507
Nail bed inflammation 14.62 9.44 12 211964 380 56079711
Lung neoplasm malignant 14.58 9.44 27 211949 17369 56062722
Thyroxine free decreased 14.57 9.44 15 211961 639 56079452
Epstein-Barr viraemia 14.54 9.44 18 211958 940 56079151
Hypokalaemia 14.53 9.44 259 211717 94178 55985913
Chorioretinitis 14.53 9.44 14 211962 550 56079541
Arteriovenous fistula 14.39 9.44 10 211966 245 56079846
Jaundice neonatal 14.38 9.44 17 211959 846 56079245
Anaphylactoid reaction 14.33 9.44 37 211939 3469 56076622
Aplastic anaemia 14.23 9.44 69 211907 8859 56071232
Fracture 14.20 9.44 29 211947 17989 56062102
Chronic graft versus host disease oral 14.18 9.44 8 211968 134 56079957
Pancreas transplant rejection 14.13 9.44 8 211968 135 56079956
Fungal infection 14.12 9.44 188 211788 32805 56047286
Product contamination 14.11 9.44 14 211962 570 56079521
Multiple fractures 14.10 9.44 5 211971 7336 56072755
Anaemia 14.09 9.44 844 211132 266667 55813424
Excessive skin 14.02 9.44 8 211968 137 56079954
Hemiparesis 14.01 9.44 133 211843 21357 56058734
Limbic encephalitis 13.98 9.44 10 211966 257 56079834
Enterocolitis bacterial 13.96 9.44 9 211967 194 56079897
Poikiloderma 13.96 9.44 9 211967 194 56079897
Leukocytosis 13.94 9.44 144 211832 23647 56056444
Head injury 13.94 9.44 48 211928 25018 56055073
Lung transplant rejection 13.93 9.44 16 211960 772 56079319
Facet joint syndrome 13.92 9.44 4 211972 6713 56073378
Polyglandular disorder 13.90 9.44 5 211971 26 56080065
Infected varicose vein 13.90 9.44 5 211971 26 56080065
Parathyroid hyperplasia 13.87 9.44 8 211968 140 56079951
Obesity 13.87 9.44 41 211935 22407 56057684
Pneumocephalus 13.87 9.44 8 211968 140 56079951
Myelitis transverse 13.86 9.44 19 211957 1098 56078993
Herpes simplex encephalitis 13.85 9.44 11 211965 332 56079759
Product administration error 13.84 9.44 37 211939 20892 56059199
H3N2 influenza 13.76 9.44 3 211973 0 56080091
Urogenital disorder 13.71 9.44 6 211970 56 56080035
Enteritis 13.70 9.44 60 211916 7383 56072708
Meningitis cryptococcal 13.68 9.44 20 211956 1227 56078864
Viral myelitis 13.66 9.44 4 211972 9 56080082
Rhinovirus infection 13.64 9.44 39 211937 3883 56076208
Ovarian fibroma 13.64 9.44 7 211969 96 56079995
Passenger lymphocyte syndrome 13.62 9.44 6 211970 57 56080034
Escherichia bacteraemia 13.62 9.44 36 211940 3424 56076667
Pneumonia fungal 13.61 9.44 45 211931 4848 56075243
Trichodysplasia spinulosa 13.59 9.44 13 211963 506 56079585
Delayed engraftment 13.58 9.44 7 211969 97 56079994
Palmar erythema 13.55 9.44 23 211953 1604 56078487
Weight increased 13.52 9.44 1022 210954 228681 55851410
Blood lactate dehydrogenase increased 13.50 9.44 128 211848 20547 56059544
Glomerulonephritis chronic 13.48 9.44 8 211968 148 56079943
Gait disturbance 13.48 9.44 491 211485 162830 55917261
Microsporidia infection 13.46 9.44 10 211966 273 56079818
Extrapyramidal disorder 13.45 9.44 16 211960 12340 56067751
Mycoplasma test positive 13.44 9.44 6 211970 59 56080032
Abnormal dreams 13.43 9.44 10 211966 9639 56070452
Graft loss 13.41 9.44 11 211965 348 56079743
Vesicoureteric reflux 13.41 9.44 9 211967 208 56079883
Polymenorrhoea 13.39 9.44 19 211957 1134 56078957
Visceral leishmaniasis 13.36 9.44 13 211963 517 56079574
Hypocapnia 13.28 9.44 11 211965 353 56079738
Glomerular filtration rate abnormal 13.27 9.44 15 211961 711 56079380
T-lymphocyte count decreased 13.27 9.44 10 211966 279 56079812
Acute myocardial infarction 13.26 9.44 64 211912 30329 56049762
Injection site induration 13.24 9.44 8 211968 8607 56071484
Infusion site pain 13.21 9.44 93 211883 13669 56066422
Transfusion 13.19 9.44 19 211957 13501 56066590
Skin striae 13.18 9.44 19 211957 1151 56078940
Atypical haemolytic uraemic syndrome 13.15 9.44 14 211962 620 56079471
Vascular rupture 13.13 9.44 22 211954 1518 56078573
Parainfluenzae virus infection 13.12 9.44 26 211950 2044 56078047
Cytomegalovirus duodenitis 13.10 9.44 4 211972 11 56080080
Paraesthesia mucosal 13.10 9.44 4 211972 11 56080080
Coagulation factor VIII level increased 13.10 9.44 4 211972 11 56080080
Synovial fluid analysis 13.08 9.44 25 211951 1913 56078178
Feeling abnormal 13.07 9.44 393 211583 133209 55946882
Stenotrophomonas sepsis 13.04 9.44 5 211971 32 56080059
Low cardiac output syndrome 13.03 9.44 10 211966 287 56079804
Pneumonia klebsiella 13.02 9.44 27 211949 2192 56077899
Flatulence 13.01 9.44 67 211909 31221 56048870
CD8 lymphocytes decreased 12.98 9.44 8 211968 159 56079932
Pneumonia cryptococcal 12.95 9.44 15 211961 730 56079361
Tachypnoea 12.95 9.44 101 211875 15329 56064762
Ankylosing spondylitis 12.94 9.44 11 211965 9919 56070172
Cytokine storm 12.91 9.44 10 211966 291 56079800
Renal artery stenosis 12.91 9.44 24 211952 1799 56078292
Hepatitis acute 12.90 9.44 64 211912 8293 56071798
Foetal growth restriction 12.89 9.44 57 211919 7042 56073049
Oral pain 12.89 9.44 53 211923 26240 56053851
Ependymoma 12.85 9.44 6 211970 66 56080025
Device leakage 12.84 9.44 4 211972 6371 56073720
Hyperoxaluria 12.80 9.44 8 211968 163 56079928
Breast cancer stage II 12.75 9.44 3 211973 5755 56074336
Central venous pressure increased 12.74 9.44 7 211969 111 56079980
Epidural lipomatosis 12.74 9.44 7 211969 111 56079980
Intestinal obstruction 12.73 9.44 58 211918 27913 56052178
B-lymphocyte count increased 12.69 9.44 7 211969 112 56079979
Complications of transplanted liver 12.67 9.44 11 211965 377 56079714
Laryngeal mass 12.66 9.44 5 211971 35 56080056
Peripheral vascular disorder 12.64 9.44 3 211973 5722 56074369
Venous thrombosis 12.63 9.44 42 211934 4538 56075553
Hepatic artery thrombosis 12.62 9.44 6 211970 69 56080022
Meningitis listeria 12.62 9.44 13 211963 554 56079537
Psychiatric decompensation 12.61 9.44 20 211956 1318 56078773
Enterocolitis viral 12.59 9.44 9 211967 231 56079860
Asthenia 12.58 9.44 1116 210860 341857 55738234
Mental status changes 12.57 9.44 86 211890 37415 56042676
Hepatitis B 12.57 9.44 36 211940 3588 56076503
Blood cholesterol increased 12.49 9.44 195 211781 72384 56007707
Adjusted calcium decreased 12.47 9.44 8 211968 171 56079920
Kidney fibrosis 12.42 9.44 23 211953 1719 56078372
Amnesia 12.38 9.44 113 211863 46209 56033882
Proctitis haemorrhagic 12.38 9.44 4 211972 14 56080077
Pneumoperitoneum 12.36 9.44 20 211956 1341 56078750
Arteriosclerosis coronary artery 12.35 9.44 7 211969 7798 56072293
Interleukin level increased 12.34 9.44 10 211966 311 56079780
Antiphospholipid syndrome 12.31 9.44 22 211954 1599 56078492
Haematemesis 12.29 9.44 61 211915 28697 56051394
Haemostasis 12.26 9.44 9 211967 241 56079850
Paraesthesia ear 12.22 9.44 8 211968 177 56079914
Pharyngeal disorder 12.22 9.44 23 211953 1740 56078351
Penicillium infection 12.21 9.44 7 211969 121 56079970
Secondary progressive multiple sclerosis 12.21 9.44 20 211956 1355 56078736
Electrocardiogram QT prolonged 12.18 9.44 139 211837 54449 56025642
Hypertensive encephalopathy 12.17 9.44 13 211963 578 56079513
Creatinine urine increased 12.16 9.44 9 211967 244 56079847
Influenza 12.16 9.44 456 211520 94805 55985286
Sputum discoloured 12.14 9.44 22 211954 14270 56065821
Hypoxia 12.12 9.44 277 211699 53620 56026471
Bronchiolitis obliterans syndrome 12.11 9.44 7 211969 123 56079968
Muscle hypertrophy 12.11 9.44 6 211970 76 56080015
Rash maculo-papular 12.08 9.44 164 211812 28743 56051348
Otitis externa 12.05 9.44 22 211954 1626 56078465
Glucose urine present 12.03 9.44 14 211962 685 56079406
Eosinophil count abnormal 12.03 9.44 12 211964 492 56079599
Akathisia 12.00 9.44 9 211967 8643 56071448
Anti-cyclic citrullinated peptide antibody 11.97 9.44 36 211940 3687 56076404
Hyperkalaemia 11.96 9.44 128 211848 50737 56029354
Disability 11.93 9.44 26 211950 15754 56064337
Metastases to central nervous system 11.89 9.44 17 211959 12119 56067972
Cytomegalovirus hepatitis 11.89 9.44 10 211966 328 56079763
Therapeutic response shortened 11.84 9.44 68 211908 9318 56070773
Nephrolithiasis 11.84 9.44 87 211889 37248 56042843
Perineal ulceration 11.78 9.44 5 211971 43 56080048
Chromoblastomycosis 11.77 9.44 4 211972 17 56080074
Meningitis staphylococcal 11.77 9.44 4 211972 17 56080074
Adult T-cell lymphoma/leukaemia 11.76 9.44 10 211966 333 56079758
Tumour lysis syndrome 11.76 9.44 60 211916 7863 56072228
Limb mass 11.75 9.44 31 211945 2945 56077146
Malacoplakia 11.72 9.44 7 211969 131 56079960
Blood catecholamines abnormal 11.69 9.44 3 211973 3 56080088
Aspergillus test positive 11.68 9.44 10 211966 336 56079755
Evans syndrome 11.66 9.44 8 211968 192 56079899
Poor quality sleep 11.63 9.44 110 211866 17645 56062446
Fungal test positive 11.62 9.44 12 211964 513 56079578
Obliterative bronchiolitis 11.61 9.44 24 211952 1944 56078147
Refractory anaemia with an excess of blasts 11.61 9.44 11 211965 423 56079668
Immunosuppression 11.60 9.44 60 211916 7904 56072187
Wound infection bacterial 11.60 9.44 12 211964 514 56079577
Gastrointestinal scarring 11.55 9.44 9 211967 264 56079827
Complement factor C4 decreased 11.55 9.44 9 211967 264 56079827
Organic brain syndrome 11.55 9.44 8 211968 195 56079896
Idiopathic pneumonia syndrome 11.53 9.44 10 211966 342 56079749
Tuberous sclerosis complex 11.52 9.44 6 211970 85 56080006
Blindness 11.51 9.44 113 211863 18308 56061783
Muscle strain 11.50 9.44 7 211969 7501 56072590
Foetal exposure during delivery 11.49 9.44 5 211971 46 56080045
Breast abscess 11.48 9.44 21 211955 1554 56078537
Monocyte percentage decreased 11.48 9.44 8 211968 197 56079894
Oropharyngeal discomfort 11.47 9.44 40 211936 4428 56075663
Respiratory arrest 11.41 9.44 68 211908 30557 56049534
Beta 2 microglobulin increased 11.40 9.44 7 211969 138 56079953
Capillaritis 11.40 9.44 7 211969 138 56079953
Organising pneumonia 11.38 9.44 45 211931 5290 56074801
Vogt-Koyanagi-Harada disease 11.36 9.44 7 211969 139 56079952
Hepatosplenomegaly 11.34 9.44 27 211949 2406 56077685
Viral myocarditis 11.33 9.44 9 211967 272 56079819
Vasculitis necrotising 11.32 9.44 12 211964 529 56079562
Enteritis infectious 11.32 9.44 24 211952 1980 56078111
Anogenital warts 11.29 9.44 11 211965 438 56079653
Acute lymphocytic leukaemia recurrent 11.27 9.44 26 211950 2271 56077820
Thrombocytosis 11.26 9.44 45 211931 5317 56074774
Neonatal pneumonia 11.25 9.44 4 211972 20 56080071
Mucocutaneous leishmaniasis 11.24 9.44 10 211966 354 56079737
Occult blood 11.21 9.44 18 211958 1199 56078892
Device breakage 11.20 9.44 13 211963 10134 56069957
Pre-existing condition improved 11.19 9.44 7 211969 7391 56072700
Polychondritis 11.17 9.44 11 211965 444 56079647
Eye infection toxoplasmal 11.16 9.44 9 211967 278 56079813
Viral pharyngitis 11.15 9.44 10 211966 358 56079733
Serum ferritin increased 11.12 9.44 46 211930 5519 56074572
Candida test positive 11.11 9.44 15 211961 854 56079237
Bulbar palsy 11.09 9.44 4 211972 21 56080070
Suspected COVID-19 11.08 9.44 24 211952 2009 56078082
Bone erosion 11.06 9.44 25 211951 14949 56065142
Hepatic steatosis 10.97 9.44 56 211920 26158 56053933
Complement factor C3 decreased 10.97 9.44 9 211967 285 56079806
Meningitis aseptic 10.96 9.44 39 211937 4360 56075731
Moraxella infection 10.94 9.44 10 211966 367 56079724
Pulse pressure increased 10.93 9.44 6 211970 95 56079996
Irritability 10.86 9.44 66 211910 29522 56050569
Dyspnoea 10.86 9.44 2016 209960 590561 55489530
Toxic neuropathy 10.83 9.44 10 211966 372 56079719
Hyperferritinaemia 10.81 9.44 7 211969 152 56079939
Injection site discolouration 10.80 9.44 7 211969 7252 56072839
Corynebacterium sepsis 10.79 9.44 4 211972 23 56080068
Enterobacter pneumonia 10.79 9.44 4 211972 23 56080068
Breast cancer stage I 10.73 9.44 5 211971 6225 56073866
Heliotrope rash 10.73 9.44 7 211969 154 56079937
Transaminases increased 10.73 9.44 160 211816 28610 56051481
Ageusia 10.73 9.44 19 211957 12432 56067659
Ophthalmoplegia 10.70 9.44 19 211957 1374 56078717
Dysaesthesia 10.70 9.44 37 211939 4079 56076012
Respiratory tract oedema 10.69 9.44 11 211965 468 56079623
Hypercholesterolaemia 10.67 9.44 92 211884 14381 56065710
Large intestine perforation 10.65 9.44 58 211918 7793 56072298
Hypocalcaemia 10.64 9.44 64 211912 28696 56051395
Adenoviral haemorrhagic cystitis 10.61 9.44 7 211969 157 56079934
Somnambulism 10.61 9.44 3 211973 5089 56075002
Skin erosion 10.60 9.44 26 211950 2362 56077729
Procedural pain 10.58 9.44 29 211947 16242 56063849
Cardiac disorder 10.58 9.44 116 211860 45771 56034320
Calcium ionised increased 10.56 9.44 6 211970 102 56079989
Intestinal infarction 10.54 9.44 16 211960 1015 56079076
Bursitis 10.53 9.44 154 211822 27428 56052663
Calcification of muscle 10.51 9.44 4 211972 25 56080066
Lower respiratory tract infection bacterial 10.50 9.44 10 211966 387 56079704
Haemangioma-thrombocytopenia syndrome 10.48 9.44 3 211973 6 56080085
Osseous cryptococcosis 10.48 9.44 3 211973 6 56080085
Ear neoplasm malignant 10.48 9.44 3 211973 6 56080085
Monocytopenia 10.48 9.44 5 211971 58 56080033
Enterovirus infection 10.47 9.44 15 211961 903 56079188
Hallucination, auditory 10.47 9.44 17 211959 11507 56068584
Panniculitis 10.44 9.44 13 211963 9829 56070262
Road traffic accident 10.41 9.44 62 211914 27865 56052226
Germ cell cancer 10.40 9.44 5 211971 59 56080032
Migraine 10.40 9.44 248 211728 86549 55993542
Salmonella test positive 10.38 9.44 4 211972 26 56080065
Acute motor axonal neuropathy 10.38 9.44 4 211972 26 56080065
Nerve injury 10.35 9.44 11 211965 8926 56071165
Tendon rupture 10.32 9.44 56 211920 7514 56072577
Herpes simplex reactivation 10.30 9.44 11 211965 489 56079602
Neurological symptom 10.30 9.44 41 211935 4835 56075256
Tuberculosis of eye 10.25 9.44 4 211972 27 56080064
Ureteric obstruction 10.25 9.44 21 211955 1691 56078400
Glomerulonephritis proliferative 10.24 9.44 7 211969 167 56079924
Subcutaneous emphysema 10.21 9.44 14 211962 809 56079282
Hyperuricaemia 10.19 9.44 42 211934 5031 56075060
Pneumothorax 10.19 9.44 93 211883 14774 56065317
Pulseless electrical activity 10.15 9.44 7 211969 7017 56073074
Microcytosis 10.09 9.44 7 211969 171 56079920
Back disorder 10.07 9.44 14 211962 10099 56069992
Joint injury 10.07 9.44 56 211920 25598 56054493
Cholecystectomy 10.06 9.44 13 211963 9671 56070420
Infusion site extravasation 10.05 9.44 59 211917 8151 56071940
Incision site pain 10.04 9.44 16 211960 1059 56079032
Feeling cold 10.03 9.44 123 211853 21064 56059027
Stem cell transplant 9.98 9.44 21 211955 1723 56078368
Eschar 9.96 9.44 11 211965 508 56079583
Chest pain 9.95 9.44 599 211377 189198 55890893
Pseudomonal bacteraemia 9.94 9.44 18 211958 1322 56078769
Deafness bilateral 9.93 9.44 18 211958 1323 56078768
Moyamoya disease 9.91 9.44 5 211971 66 56080025
Vessel puncture site bruise 9.90 9.44 10 211966 416 56079675
Finger deformity 9.89 9.44 50 211926 6527 56073564
Acid base balance abnormal 9.89 9.44 8 211968 248 56079843
Listeria test positive 9.89 9.44 3 211973 8 56080083
Body height decreased 9.89 9.44 12 211964 9173 56070918
Gastrointestinal hypermotility 9.88 9.44 7 211969 177 56079914
Withdrawal syndrome 9.83 9.44 36 211940 18426 56061665
Complication of device insertion 9.83 9.44 6 211970 6418 56073673
Hepatitis cholestatic 9.82 9.44 49 211927 6365 56073726
Chronic kidney disease 9.82 9.44 106 211870 41950 56038141
Hepatic failure 9.81 9.44 179 211797 33307 56046784
Antibody test abnormal 9.79 9.44 11 211965 518 56079573
Larynx irritation 9.79 9.44 6 211970 118 56079973
Administration site oedema 9.78 9.44 4 211972 31 56080060
Pneumonia acinetobacter 9.78 9.44 4 211972 31 56080060
Spinal stroke 9.78 9.44 4 211972 31 56080060
Spinal operation 9.77 9.44 8 211968 7348 56072743
Haemorrhagic cyst 9.75 9.44 7 211969 181 56079910
Parkinsonism 9.73 9.44 13 211963 9533 56070558
Paraplegia 9.72 9.44 26 211950 2491 56077600
Drug level below therapeutic 9.71 9.44 37 211939 4276 56075815
Acne 9.70 9.44 122 211854 21014 56059077
Respiratory gas exchange disorder 9.70 9.44 9 211967 337 56079754
Cytomegalovirus gastritis 9.68 9.44 7 211969 183 56079908
Paralogism 9.67 9.44 4 211972 32 56080059
Glomerulonephritis membranous 9.67 9.44 12 211964 628 56079463
Hepatic vein occlusion 9.65 9.44 5 211971 70 56080021
Agranulocytosis 9.65 9.44 129 211847 22530 56057561
Pneumonia pseudomonal 9.64 9.44 24 211952 2200 56077891
Visual tracking test abnormal 9.63 9.44 3 211973 9 56080082
Myocardiac abscess 9.63 9.44 3 211973 9 56080082
Angioedema 9.62 9.44 214 211762 41239 56038852
Hypomagnesaemia 9.61 9.44 55 211921 24960 56055131
Acarodermatitis 9.60 9.44 15 211961 976 56079115
Incorrect product administration duration 9.60 9.44 15 211961 10311 56069780
Angina unstable 9.59 9.44 7 211969 6814 56073277
Carcinoma in situ 9.57 9.44 6 211970 123 56079968
Nitrite urine 9.57 9.44 4 211972 33 56080058
Drug specific antibody present 9.53 9.44 33 211943 3639 56076452
Oropharyngeal plaque 9.47 9.44 8 211968 264 56079827
Hepatic vein stenosis 9.47 9.44 4 211972 34 56080057
Exostosis 9.45 9.44 27 211949 14916 56065175

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 971.85 10.55 3540 136275 343734 31213795
Cytomegalovirus infection 812.94 10.55 753 139062 23954 31533575
Product use in unapproved indication 487.57 10.55 1236 138579 97935 31459594
Drug ineffective for unapproved indication 461.12 10.55 476 139339 17314 31540215
Death 413.02 10.55 596 139219 359973 31197556
Transplant rejection 403.44 10.55 338 139477 9370 31548159
Infusion related reaction 391.88 10.55 735 139080 47320 31510209
Graft versus host disease 332.98 10.55 313 139502 10134 31547395
Kidney transplant rejection 324.42 10.55 264 139551 7018 31550511
Completed suicide 321.11 10.55 21 139794 91493 31466036
Pneumocystis jirovecii pneumonia 315.73 10.55 396 139419 17855 31539674
Drug abuse 314.35 10.55 18 139797 87740 31469789
Bronchopulmonary aspergillosis 295.62 10.55 332 139483 13302 31544227
Multiple organ dysfunction syndrome 286.13 10.55 802 139013 67401 31490128
Aspergillus infection 278.23 10.55 297 139518 11231 31546298
Mucormycosis 258.85 10.55 207 139608 5363 31552166
Cytomegalovirus viraemia 254.63 10.55 222 139593 6503 31551026
Drug ineffective 253.76 10.55 2759 137056 392814 31164715
Epstein-Barr virus infection 248.23 10.55 222 139593 6731 31550798
Product dose omission issue 231.61 10.55 88 139727 105498 31452031
Thrombotic microangiopathy 225.81 10.55 241 139574 9110 31548419
Posterior reversible encephalopathy syndrome 220.19 10.55 238 139577 9129 31548400
Toxicity to various agents 219.05 10.55 288 139527 181199 31376330
Fall 216.83 10.55 303 139512 185786 31371743
Respiratory failure 214.33 10.55 951 138864 100498 31457031
Strongyloidiasis 213.50 10.55 136 139679 2430 31555099
Post transplant lymphoproliferative disorder 209.03 10.55 190 139625 5886 31551643
Acute graft versus host disease in skin 194.08 10.55 165 139650 4667 31552862
Acute graft versus host disease 191.57 10.55 182 139633 5971 31551558
Pneumatosis intestinalis 189.91 10.55 146 139669 3565 31553964
Complications of transplanted kidney 189.49 10.55 155 139660 4150 31553379
Fatigue 186.39 10.55 804 139011 334402 31223127
Cytomegalovirus test positive 176.15 10.55 138 139677 3467 31554062
Graft versus host disease in gastrointestinal tract 176.13 10.55 136 139679 3343 31554186
Adenovirus infection 176.09 10.55 155 139660 4599 31552930
Septic shock 175.88 10.55 666 139149 65492 31492037
Dizziness 173.43 10.55 389 139426 198758 31358771
Blood pressure diastolic abnormal 170.40 10.55 141 139674 3838 31553691
Blood pressure fluctuation 163.52 10.55 330 139485 22406 31535123
Syncope 158.85 10.55 89 139726 85093 31472436
Polyomavirus-associated nephropathy 156.06 10.55 128 139687 3440 31554089
Nausea 153.66 10.55 768 139047 307179 31250350
Acute graft versus host disease in intestine 150.76 10.55 109 139706 2417 31555112
Haemophagocytic lymphohistiocytosis 138.13 10.55 211 139604 11467 31546062
Oxygen saturation decreased 137.63 10.55 503 139312 48612 31508917
Myocardial infarction 136.75 10.55 180 139635 113274 31444255
Intentional overdose 135.32 10.55 13 139802 41376 31516153
Graft versus host disease in skin 134.67 10.55 118 139697 3479 31554050
Cardiac failure congestive 134.11 10.55 93 139722 79294 31478235
Cytomegalovirus infection reactivation 133.46 10.55 122 139693 3807 31553722
BK virus infection 133.17 10.55 137 139678 4958 31552571
Disseminated intravascular coagulation 132.38 10.55 285 139530 20252 31537277
Pneumonia cytomegaloviral 128.54 10.55 104 139711 2740 31554789
Asthenia 126.51 10.55 536 139279 224219 31333310
Acute graft versus host disease in liver 125.60 10.55 78 139737 1330 31556199
Cystitis haemorrhagic 125.37 10.55 135 139680 5154 31552375
Steroid diabetes 124.98 10.55 87 139728 1813 31555716
Blood pressure systolic abnormal 119.06 10.55 103 139712 2984 31554545
Chronic graft versus host disease 116.42 10.55 119 139696 4273 31553256
Candida infection 115.73 10.55 235 139580 16023 31541506
Hospitalisation 115.14 10.55 38 139777 49769 31507760
Overdose 108.61 10.55 128 139687 84536 31472993
Cerebrovascular accident 107.61 10.55 115 139700 79369 31478160
Dehydration 104.88 10.55 231 139584 118880 31438649
Acute respiratory distress syndrome 104.16 10.55 290 139525 24250 31533279
Nocardiosis 104.00 10.55 101 139714 3406 31554123
Enterococcal infection 102.19 10.55 157 139658 8574 31548955
Coronary artery disease 99.99 10.55 39 139776 46048 31511481
Pseudomonas infection 99.88 10.55 180 139635 11221 31546308
Lymphocyte count decreased 96.65 10.55 253 139562 20396 31537133
Blood pressure systolic increased 95.71 10.55 243 139572 19227 31538302
Constipation 93.13 10.55 261 139554 123730 31433799
Human herpesvirus 6 infection 91.50 10.55 73 139742 1884 31555645
Pneumomediastinum 91.45 10.55 76 139739 2081 31555448
Parvovirus B19 infection 90.32 10.55 51 139764 723 31556806
Focal segmental glomerulosclerosis 89.40 10.55 72 139743 1884 31555645
Disseminated mucormycosis 89.29 10.55 43 139772 429 31557100
Suicide attempt 86.82 10.55 28 139787 37220 31520309
Intentional product use issue 86.82 10.55 439 139376 48908 31508621
Plasma cell myeloma 83.16 10.55 76 139739 56455 31501074
Hypoglycaemia 81.70 10.55 63 139752 50883 31506646
Depression 81.67 10.55 174 139641 90641 31466888
Klebsiella infection 79.89 10.55 132 139683 7671 31549858
Delayed graft function 79.28 10.55 70 139745 2085 31555444
Bacterial sepsis 79.10 10.55 102 139713 4726 31552803
Immunosuppressant drug level increased 77.87 10.55 106 139709 5179 31552350
Vomiting 76.32 10.55 627 139188 223346 31334183
Drug interaction 76.08 10.55 573 139242 207970 31349559
Wrong technique in product usage process 76.07 10.55 26 139789 33317 31524212
Blood pressure increased 72.73 10.55 600 139215 79033 31478496
Heart rate decreased 72.11 10.55 281 139534 27985 31529544
Psoriasis 70.89 10.55 61 139754 46658 31510871
Central nervous system fungal infection 70.53 10.55 34 139781 340 31557189
Pyrexia 70.42 10.55 1795 138020 302045 31255484
Rebound effect 70.10 10.55 70 139745 2443 31555086
Drug resistance 69.75 10.55 245 139570 23208 31534321
Systemic mycosis 69.45 10.55 55 139760 1404 31556125
Liver transplant rejection 69.25 10.55 63 139752 1953 31555576
Injection site pain 69.25 10.55 33 139782 34601 31522928
Progressive multifocal leukoencephalopathy 68.95 10.55 136 139679 9077 31548452
Infection reactivation 68.90 10.55 53 139762 1295 31556234
Cytomegalovirus colitis 68.15 10.55 70 139745 2528 31555001
Feeling abnormal 67.03 10.55 92 139723 56910 31500619
Anaphylactic shock 66.89 10.55 174 139641 13971 31543558
Cryptococcosis 66.84 10.55 66 139749 2272 31555257
Lymphopenia 66.47 10.55 175 139640 14154 31543375
Fungal infection 64.76 10.55 175 139640 14376 31543153
Mycobacterium chelonae infection 63.36 10.55 40 139775 703 31556826
Decreased appetite 63.20 10.55 406 139409 152811 31404718
Epstein-Barr virus associated lymphoproliferative disorder 63.14 10.55 57 139758 1749 31555780
Cytomegalovirus enteritis 63.12 10.55 34 139781 437 31557092
International normalised ratio increased 62.79 10.55 64 139751 45159 31512370
Nephropathy toxic 62.49 10.55 148 139667 11205 31546324
Therapy non-responder 62.43 10.55 305 139510 33506 31524023
Hyperglycaemia 61.70 10.55 321 139494 36155 31521374
Diarrhoea 61.57 10.55 1140 138675 351269 31206260
Cushingoid 61.20 10.55 65 139750 2442 31555087
Pulmonary mucormycosis 61.08 10.55 38 139777 650 31556879
Confusional state 60.39 10.55 343 139472 132991 31424538
Cytomegalovirus oesophagitis 58.80 10.55 33 139782 462 31557067
Condition aggravated 58.39 10.55 1032 138783 162977 31394552
Prostate cancer 58.39 10.55 48 139767 37553 31519976
Intentional product misuse 58.25 10.55 49 139766 37902 31519627
Pneumocystis jirovecii infection 56.33 10.55 51 139764 1571 31555958
Transplant dysfunction 56.20 10.55 61 139754 2350 31555179
Pulmonary alveolar haemorrhage 55.70 10.55 104 139711 6662 31550867
Myalgia 55.49 10.55 166 139649 77092 31480437
Renal tubular necrosis 55.46 10.55 167 139648 14592 31542937
Herpes simplex 54.06 10.55 89 139726 5156 31552373
Serotonin syndrome 53.85 10.55 9 139806 18764 31538765
Granulomatosis with polyangiitis 53.27 10.55 42 139773 1065 31556464
Orthostatic hypotension 52.99 10.55 20 139795 24099 31533430
Leukopenia 52.93 10.55 436 139379 57392 31500137
Staphylococcal sepsis 52.35 10.55 121 139694 9016 31548513
Suicidal ideation 52.29 10.55 50 139765 36356 31521173
Enterobacter infection 51.87 10.55 56 139759 2144 31555385
Oedema peripheral 51.67 10.55 279 139536 109560 31447969
Cardiac disorder 51.64 10.55 58 139757 39156 31518373
Lymphocyte percentage decreased 51.62 10.55 54 139761 1993 31555536
Chronic allograft nephropathy 51.48 10.55 42 139773 1120 31556409
Renal tubular atrophy 51.46 10.55 41 139774 1056 31556473
Rhabdomyolysis 51.35 10.55 129 139686 63452 31494077
Cytomegalovirus chorioretinitis 50.88 10.55 69 139746 3359 31554170
Red blood cells urine positive 49.95 10.55 49 139766 1673 31555856
Muscle spasms 49.63 10.55 146 139669 68172 31489357
Chorioretinopathy 49.49 10.55 45 139770 1394 31556135
Renal transplant failure 49.39 10.55 39 139776 991 31556538
Amoebic colitis 48.18 10.55 18 139797 88 31557441
Disseminated cryptococcosis 47.70 10.55 43 139772 1317 31556212
Cytomegalovirus enterocolitis 47.49 10.55 36 139779 860 31556669
COVID-19 47.34 10.55 408 139407 54413 31503116
Product prescribing error 47.14 10.55 14 139801 19628 31537901
Aggression 47.12 10.55 57 139758 37234 31520295
Graft versus host disease in liver 47.08 10.55 40 139775 1130 31556399
Neutrophil percentage increased 46.56 10.55 48 139767 1741 31555788
Aplastic anaemia 46.41 10.55 116 139699 9087 31548442
Pneumoretroperitoneum 45.83 10.55 19 139796 128 31557401
Peripheral swelling 45.09 10.55 151 139664 67714 31489815
Myopathy 44.81 10.55 127 139688 10725 31546804
COVID-19 pneumonia 44.58 10.55 140 139675 12515 31545014
Corynebacterium infection 44.55 10.55 28 139787 488 31557041
Pemphigus 44.22 10.55 42 139773 1377 31556152
Intentional self-injury 44.00 10.55 4 139811 13311 31544218
Disease recurrence 43.97 10.55 181 139634 18480 31539049
Dyspnoea 43.89 10.55 1167 138648 342312 31215217
Lethargy 43.79 10.55 64 139751 38577 31518952
Oliguria 42.90 10.55 101 139714 7616 31549913
Psoriatic arthropathy 42.83 10.55 17 139798 19866 31537663
Drug effective for unapproved indication 42.67 10.55 47 139768 1841 31555688
Adenoviral hepatitis 42.50 10.55 27 139788 480 31557049
Gastroenteritis norovirus 42.42 10.55 41 139774 1374 31556155
Accidental overdose 42.39 10.55 14 139801 18336 31539193
Pneumonia fungal 42.12 10.55 89 139726 6240 31551289
Pneumonia pseudomonal 42.06 10.55 64 139751 3465 31554064
Kidney fibrosis 41.70 10.55 49 139766 2061 31555468
Necrotising retinitis 41.49 10.55 32 139783 785 31556744
Acinetobacter infection 41.35 10.55 36 139779 1052 31556477
Sepsis 41.26 10.55 918 138897 151011 31406518
Transient ischaemic attack 40.83 10.55 28 139787 24028 31533501
Pneumonia cryptococcal 40.57 10.55 32 139783 812 31556717
Erectile dysfunction 40.53 10.55 17 139798 19218 31538311
Dural arteriovenous fistula 40.48 10.55 13 139802 36 31557493
Hypoalbuminaemia 39.77 10.55 123 139692 10905 31546624
Sedation 39.58 10.55 17 139798 18948 31538581
Balance disorder 39.53 10.55 65 139750 37357 31520172
Rhinocerebral mucormycosis 39.33 10.55 24 139791 396 31557133
Urine analysis abnormal 39.08 10.55 45 139770 1852 31555677
Viral haemorrhagic cystitis 38.95 10.55 34 139781 997 31556532
Serum sickness 38.85 10.55 44 139771 1778 31555751
Somnolence 38.71 10.55 268 139547 99177 31458352
Treatment noncompliance 38.39 10.55 34 139781 25650 31531879
Staphylococcal infection 38.38 10.55 249 139566 30383 31527146
Loss of personal independence in daily activities 38.17 10.55 41 139774 28247 31529282
Blood pressure diastolic increased 38.11 10.55 68 139747 4205 31553324
Viraemia 38.05 10.55 35 139780 1101 31556428
Intestinal ischaemia 37.86 10.55 91 139724 6954 31550575
Back pain 37.76 10.55 305 139510 109108 31448421
Transplant failure 37.69 10.55 57 139758 3069 31554460
Full blood count decreased 37.55 10.55 13 139802 16527 31541002
Cytokine release syndrome 37.32 10.55 159 139656 16483 31541046
Urine abnormality 36.99 10.55 43 139772 1788 31555741
Pneumonia acinetobacter 36.90 10.55 14 139801 72 31557457
Pulmonary nocardiosis 36.83 10.55 27 139788 612 31556917
Pain 36.71 10.55 591 139224 186168 31371361
Diffuse alveolar damage 36.66 10.55 46 139769 2073 31555456
Epstein-Barr viraemia 36.62 10.55 33 139782 1010 31556519
Malignant neoplasm progression 36.39 10.55 202 139613 78796 31478733
Diabetes mellitus 36.35 10.55 316 139499 42240 31515289
Phaeohyphomycosis 36.17 10.55 30 139785 819 31556710
Pneumothorax 35.96 10.55 159 139656 16751 31540778
Escherichia infection 35.72 10.55 91 139724 7213 31550316
Incision site pain 35.27 10.55 42 139773 1792 31555737
Gait disturbance 35.24 10.55 199 139616 77296 31480233
Immunosuppressant drug level decreased 35.24 10.55 34 139781 1137 31556392
Large intestine perforation 35.15 10.55 93 139722 7543 31549986
Glomerulonephritis 35.14 10.55 42 139773 1799 31555730
American trypanosomiasis 35.08 10.55 19 139796 247 31557282
Atrial fibrillation 34.91 10.55 327 139488 113456 31444073
Intensive care unit acquired weakness 34.89 10.55 31 139784 931 31556598
Pain in extremity 34.78 10.55 336 139479 115867 31441662
Product quality issue 34.33 10.55 14 139801 16097 31541432
Skin necrosis 34.14 10.55 76 139739 5522 31552007
Necrosis ischaemic 34.06 10.55 18 139797 222 31557307
Chest pain 33.82 10.55 341 139474 116616 31440913
Mycobacterium abscessus infection 33.49 10.55 25 139790 583 31556946
Cutaneous mucormycosis 33.36 10.55 16 139799 158 31557371
Adverse event 33.26 10.55 16 139799 16689 31540840
Anxiety 33.16 10.55 250 139565 90783 31466746
Interstitial lung disease 33.01 10.55 415 139400 60988 31496541
Extrapyramidal disorder 33.01 10.55 6 139809 11772 31545757
Abdominal discomfort 32.72 10.55 117 139698 51450 31506079
JC virus infection 32.46 10.55 42 139773 1952 31555577
Ureteric stenosis 32.39 10.55 32 139783 1102 31556427
Vasculitis 32.36 10.55 97 139718 8453 31549076
Dyspnoea exertional 31.97 10.55 78 139737 38759 31518770
Bacteraemia 31.78 10.55 158 139657 17476 31540053
Multiple sclerosis relapse 31.72 10.55 121 139694 11926 31545603
Skin striae 31.69 10.55 23 139792 513 31557016
Fusarium infection 31.68 10.55 31 139784 1055 31556474
Contusion 31.61 10.55 61 139754 32967 31524562
Perinephric abscess 31.60 10.55 11 139804 42 31557487
Human herpesvirus 8 infection 31.54 10.55 28 139787 840 31556689
Insomnia 31.52 10.55 267 139548 94569 31462960
Pyelonephritis acute 31.47 10.55 40 139775 1826 31555703
Haemolytic anaemia 31.45 10.55 105 139710 9691 31547838
Intra-abdominal haemorrhage 31.24 10.55 43 139772 2123 31555406
Renal tubular injury 31.12 10.55 27 139788 785 31556744
Crystal urine present 31.08 10.55 21 139794 416 31557113
Varicella zoster virus infection 31.07 10.55 37 139778 1579 31555950
Hallucination 31.00 10.55 103 139712 46307 31511222
Disseminated strongyloidiasis 31.00 10.55 14 139801 119 31557410
Injection site swelling 30.86 10.55 4 139811 10083 31547446
Diffuse large B-cell lymphoma 30.81 10.55 96 139719 8545 31548984
Porphyria acute 30.75 10.55 19 139796 321 31557208
Osteonecrosis 30.63 10.55 132 139683 13752 31543777
Engraftment syndrome 30.43 10.55 28 139787 881 31556648
Protein urine present 30.24 10.55 67 139748 4853 31552676
Penicillium infection 29.68 10.55 13 139802 102 31557427
Malaise 29.63 10.55 544 139271 167967 31389562
Memory impairment 29.52 10.55 79 139736 38051 31519478
Neuroleptic malignant syndrome 29.48 10.55 19 139796 16850 31540679
Cytomegalovirus hepatitis 29.44 10.55 20 139795 400 31557129
Haemodynamic instability 29.41 10.55 94 139721 8481 31549048
Proteinuria 29.36 10.55 149 139666 16614 31540915
Pneumonia bacterial 29.27 10.55 106 139709 10190 31547339
Acute myocardial infarction 29.22 10.55 120 139695 50703 31506826
Depressed mood 29.11 10.55 21 139794 17554 31539975
Hypophagia 28.58 10.55 33 139782 22009 31535520
Fungaemia 28.28 10.55 43 139772 2326 31555203
Product substitution issue 28.24 10.55 4 139811 9428 31548101
Osteomyelitis fungal 28.14 10.55 16 139799 230 31557299
Parvovirus infection 28.11 10.55 20 139795 432 31557097
Renal impairment 28.09 10.55 536 139279 85813 31471716
Neuropathy peripheral 27.90 10.55 207 139608 75442 31482087
Febrile bone marrow aplasia 27.82 10.55 87 139728 7759 31549770
Blood beta-D-glucan increased 27.79 10.55 19 139796 384 31557145
Opportunistic infection 27.75 10.55 34 139781 1495 31556034
Disseminated varicella zoster virus infection 27.72 10.55 16 139799 237 31557292
Systemic candida 27.52 10.55 50 139765 3136 31554393
Blood creatine phosphokinase increased 27.46 10.55 94 139721 41880 31515649
Glomerulosclerosis 27.43 10.55 24 139791 706 31556823
Headache 27.18 10.55 610 139205 183042 31374487
Bronchopleural fistula 27.14 10.55 20 139795 457 31557072
Toxic epidermal necrolysis 27.14 10.55 163 139652 19361 31538168
Blood pressure diastolic decreased 26.72 10.55 87 139728 7926 31549603
Disseminated blastomycosis 26.67 10.55 12 139803 101 31557428
Drug withdrawal syndrome 26.63 10.55 26 139789 18724 31538805
Full blood count abnormal 26.47 10.55 20 139795 16327 31541202
Respiratory arrest 26.45 10.55 47 139768 26210 31531319
Tremor 26.36 10.55 213 139602 76207 31481322
Monocyte percentage increased 26.33 10.55 26 139789 895 31556634
Nephrotic syndrome 26.08 10.55 79 139736 6924 31550605
Anaphylactic reaction 26.05 10.55 221 139594 29332 31528197
Hyperkalaemia 25.73 10.55 172 139643 64179 31493350
Red blood cell schistocytes present 25.71 10.55 15 139800 227 31557302
Obliterative bronchiolitis 25.58 10.55 29 139786 1173 31556356
Symptom masked 25.52 10.55 21 139794 567 31556962
Low birth weight baby 25.37 10.55 78 139737 6892 31550637
Lymphoproliferative disorder 25.24 10.55 43 139772 2562 31554967
Encephalitis autoimmune 25.23 10.55 22 139793 644 31556885
Respiratory distress 25.03 10.55 242 139573 33311 31524218
Gastrointestinal candidiasis 24.98 10.55 13 139802 155 31557374
Drug intolerance 24.53 10.55 132 139683 51901 31505628
Dry mouth 24.44 10.55 44 139771 24414 31533115
Dry skin 24.43 10.55 47 139768 25434 31532095
Cholelithiasis 24.37 10.55 30 139785 19449 31538080
Injection site erythema 24.32 10.55 17 139798 14445 31543084
Cryptococcal meningoencephalitis 24.22 10.55 12 139803 128 31557401
Erythema 24.10 10.55 493 139322 79912 31477617
Sleep disorder 24.06 10.55 50 139765 26298 31531231
Reticulocytosis 24.04 10.55 15 139800 258 31557271
Pulmonary haemorrhage 24.04 10.55 95 139720 9520 31548009
Antineutrophil cytoplasmic antibody positive 23.99 10.55 21 139794 618 31556911
Hepatic failure 23.97 10.55 235 139580 32467 31525062
Hypertension 23.96 10.55 737 139078 127363 31430166
Peritonitis 23.94 10.55 132 139683 15195 31542334
Angiosarcoma 23.90 10.55 16 139799 312 31557217
Respiratory tract infection fungal 23.86 10.55 22 139793 694 31556835
Pseudomonal sepsis 23.70 10.55 47 139768 3149 31554380
Complications of transplant surgery 23.69 10.55 19 139796 494 31557035
Specific gravity urine increased 23.67 10.55 12 139803 135 31557394
Therapy cessation 23.64 10.55 19 139796 15036 31542493
Nightmare 23.60 10.55 12 139803 12125 31545404
General physical health deterioration 23.60 10.55 355 139460 113080 31444449
Sideroblastic anaemia 23.59 10.55 14 139801 219 31557310
Renal graft infection 23.54 10.55 15 139800 268 31557261
Laboratory test abnormal 23.51 10.55 29 139786 18785 31538744
Encephalitis fungal 23.48 10.55 13 139802 177 31557352
Staphylococcal mediastinitis 23.45 10.55 9 139806 48 31557481
Chills 23.34 10.55 458 139357 73692 31483837
Cytomegalovirus gastritis 23.32 10.55 14 139801 224 31557305
Apoptosis 23.32 10.55 14 139801 224 31557305
Neck pain 23.08 10.55 41 139774 22869 31534660
Hypogammaglobulinaemia 23.05 10.55 73 139742 6554 31550975
Anaemia 23.03 10.55 742 139073 212780 31344749
Systemic inflammatory response syndrome 22.97 10.55 70 139745 6155 31551374
Viral cardiomyopathy 22.89 10.55 8 139807 31 31557498
Neuromyelitis optica spectrum disorder 22.85 10.55 12 139803 146 31557383
Adenoviral haemorrhagic cystitis 22.75 10.55 17 139798 397 31557132
Thrombosis 22.72 10.55 112 139703 45039 31512490
Leukocytosis 22.56 10.55 171 139644 21943 31535586
Graft complication 22.55 10.55 16 139799 344 31557185
Palmar-plantar erythrodysaesthesia syndrome 22.54 10.55 21 139794 15462 31542067
Herpes zoster 22.53 10.55 228 139587 31765 31525764
Haemolytic uraemic syndrome 22.47 10.55 36 139779 2038 31555491
Acute haemorrhagic leukoencephalitis 22.44 10.55 6 139809 6 31557523
Hepatic cytolysis 22.44 10.55 101 139714 10722 31546807
Immunosuppression 22.43 10.55 65 139750 5558 31551971
Poisoning 22.19 10.55 9 139806 10382 31547147
Respiratory disorder 22.11 10.55 145 139670 17755 31539774
Enterococcal bacteraemia 22.11 10.55 32 139783 1656 31555873
Adverse drug reaction 22.04 10.55 49 139766 25152 31532377
Human polyomavirus infection 21.92 10.55 21 139794 696 31556833
Dysgeusia 21.88 10.55 44 139771 23422 31534107
Red cell distribution width increased 21.86 10.55 63 139752 5371 31552158
Lung abscess 21.85 10.55 39 139776 2412 31555117
Quadriplegia 21.77 10.55 31 139784 1580 31555949
Unevaluable event 21.72 10.55 66 139749 30509 31527020
C-reactive protein abnormal 21.68 10.55 4 139811 7765 31549764
Viral sepsis 21.65 10.55 10 139805 90 31557439
Cold type haemolytic anaemia 21.56 10.55 10 139805 91 31557438
Hypocalcaemia 21.55 10.55 40 139775 21938 31535591
Gastric disorder 21.53 10.55 12 139803 11516 31546013
Bronchopneumopathy 21.50 10.55 17 139798 433 31557096
Fungal skin infection 21.49 10.55 39 139776 2444 31555085
Dyskinesia 21.45 10.55 37 139778 20873 31536656
Abnormal dreams 21.32 10.55 3 139812 7105 31550424
Thrombocytopenia 21.31 10.55 800 139015 141947 31415582
Therapeutic response decreased 21.17 10.55 194 139621 26315 31531214
Coronary artery dilatation 21.14 10.55 7 139808 22 31557507
Unresponsive to stimuli 21.09 10.55 52 139763 25748 31531781
Agitation 21.05 10.55 146 139669 54023 31503506
Osteoporosis 21.02 10.55 104 139711 11479 31546050
Diarrhoea haemorrhagic 21.00 10.55 67 139748 6039 31551490
Subdural haematoma 20.93 10.55 32 139783 18939 31538590
Accelerated idioventricular rhythm 20.92 10.55 10 139805 98 31557431
Candida sepsis 20.87 10.55 26 139789 1163 31556366
Polychondritis 20.86 10.55 13 139802 223 31557306
Injection site haemorrhage 20.86 10.55 7 139808 9078 31548451
Amoebiasis 20.83 10.55 9 139806 68 31557461
Atypical mycobacterial pneumonia 20.79 10.55 11 139804 136 31557393
Cardiac failure 20.73 10.55 261 139554 85692 31471837
Splenic embolism 20.72 10.55 12 139803 179 31557350
Pneumonia klebsiella 20.69 10.55 42 139773 2862 31554667
Wound evisceration 20.66 10.55 10 139805 101 31557428
Graft loss 20.66 10.55 22 139793 829 31556700
Oesophageal carcinoma 20.65 10.55 5 139810 8028 31549501
Systemic lupus erythematosus 20.64 10.55 43 139772 2985 31554544
Scopulariopsis infection 20.57 10.55 10 139805 102 31557427
Central nervous system infection 20.50 10.55 18 139797 532 31556997
Device issue 20.44 10.55 6 139809 8478 31549051
Injection site bruising 20.43 10.55 5 139810 7970 31549559
Pulmonary embolism 20.42 10.55 246 139569 81400 31476129
Herpes simplex viraemia 20.40 10.55 9 139806 72 31557457
Feeling hot 20.36 10.55 132 139683 16101 31541428
Immune effector cell-associated neurotoxicity syndrome 20.27 10.55 38 139777 2441 31555088
Osmotic demyelination syndrome 20.26 10.55 20 139795 688 31556841
Foetal growth restriction 20.20 10.55 49 139766 3766 31553763
Abdominal pain upper 20.01 10.55 183 139632 63819 31493710
Enterococcal sepsis 19.99 10.55 29 139786 1504 31556025
Hyponatraemia 19.76 10.55 219 139596 73580 31483949
Akathisia 19.68 10.55 4 139811 7249 31550280
Fluid retention 19.49 10.55 51 139764 24751 31532778
Meningitis cryptococcal 19.49 10.55 36 139779 2287 31555242
Torulopsis infection 19.41 10.55 6 139809 14 31557515
Pathogen resistance 19.41 10.55 83 139732 8618 31548911
Autoimmune haemolytic anaemia 19.39 10.55 51 139764 4121 31553408
Engraft failure 19.35 10.55 16 139799 435 31557094
Bradycardia 19.26 10.55 204 139611 69123 31488406
Electrocardiogram QT prolonged 19.24 10.55 94 139721 37893 31519636
Cystitis escherichia 19.23 10.55 11 139804 160 31557369
Haematemesis 19.22 10.55 54 139761 25599 31531930
Injection site reaction 19.19 10.55 14 139801 11637 31545892
Septic pulmonary embolism 19.12 10.55 6 139809 15 31557514
Lung transplant rejection 19.10 10.55 20 139795 739 31556790
Cerebral aspergillosis 19.04 10.55 27 139788 1371 31556158
Immune reconstitution inflammatory syndrome 19.01 10.55 79 139736 8099 31549430
Hepatocellular injury 18.93 10.55 161 139654 21383 31536146
Periumbilical abscess 18.92 10.55 8 139807 57 31557472
Neurological decompensation 18.72 10.55 38 139777 2589 31554940
Alveolar proteinosis 18.58 10.55 15 139800 394 31557135
Urinary retention 18.54 10.55 81 139734 33644 31523885
Encephalopathy 18.53 10.55 222 139593 32252 31525277
Megacolon 18.48 10.55 29 139786 1613 31555916
Pneumoperitoneum 18.46 10.55 29 139786 1614 31555915
Meningitis fungal 18.41 10.55 9 139806 93 31557436
Incorrect dose administered 18.38 10.55 88 139727 35664 31521865
Peritoneal candidiasis 18.33 10.55 6 139809 18 31557511
Vitritis infective 18.33 10.55 6 139809 18 31557511
Pharyngeal paraesthesia 18.32 10.55 17 139798 541 31556988
Paranoia 18.29 10.55 12 139803 10543 31546986
Lupus nephritis 18.18 10.55 13 139802 283 31557246
Cerebral fungal infection 18.15 10.55 12 139803 229 31557300
Bladder cancer 18.08 10.55 23 139792 14702 31542827
Blood glucose decreased 18.05 10.55 17 139798 12454 31545075
Dyspepsia 18.01 10.55 78 139737 32475 31525054
Prescribed overdose 18.00 10.55 9 139806 9183 31548346
Salivary hypersecretion 17.90 10.55 6 139809 7786 31549743
Labelled drug-drug interaction medication error 17.84 10.55 19 139796 13144 31544385
Hepatic artery thrombosis 17.84 10.55 12 139803 236 31557293
Bursitis infective 17.78 10.55 17 139798 562 31556967
White blood cells urine positive 17.76 10.55 24 139791 1164 31556365
Heart transplant rejection 17.75 10.55 24 139791 1165 31556364
Fungal sepsis 17.72 10.55 20 139795 805 31556724
Road traffic accident 17.72 10.55 28 139787 16353 31541176
Myelocyte present 17.71 10.55 4 139811 0 31557529
Blood sodium decreased 17.71 10.55 25 139790 15290 31542239
Urticaria 17.67 10.55 354 139461 57163 31500366
Contraindicated product administered 17.65 10.55 38 139777 19734 31537795
Organising pneumonia 17.64 10.55 59 139756 5451 31552078
Bordetella infection 17.54 10.55 9 139806 104 31557425
Hypersomnia 17.50 10.55 14 139801 11105 31546424
Respiratory depression 17.47 10.55 23 139792 14487 31543042
Epstein-Barr virus infection reactivation 17.47 10.55 20 139795 818 31556711
Pneumonia escherichia 17.43 10.55 14 139801 365 31557164
Disseminated trichosporonosis 17.42 10.55 7 139808 43 31557486
Gonococcal infection 17.42 10.55 7 139808 43 31557486
Cerebral venous thrombosis 17.41 10.55 18 139797 655 31556874
Underdose 17.31 10.55 18 139797 12589 31544940
Irritability 17.28 10.55 48 139767 22841 31534688
Diabetic ketoacidosis 17.26 10.55 30 139785 16875 31540654
Immune-mediated lung disease 17.25 10.55 23 139792 1101 31556428
Herpes oesophagitis 17.22 10.55 10 139805 150 31557379
Listeriosis 17.22 10.55 21 139794 919 31556610
Throat irritation 17.17 10.55 84 139731 9230 31548299
Hepatitis A 17.15 10.55 15 139800 441 31557088
Dysphagia 17.14 10.55 167 139648 57509 31500020
IgA nephropathy 17.13 10.55 23 139792 1109 31556420
Product storage error 17.02 10.55 5 139810 7061 31550468
Disturbance in attention 17.01 10.55 47 139768 22403 31535126
Bacterial test 16.99 10.55 10 139805 154 31557375
Mobility decreased 16.97 10.55 63 139752 27406 31530123
Monocytopenia 16.86 10.55 8 139807 77 31557452
Haptoglobin decreased 16.86 10.55 16 139799 524 31557005
Abdominal abscess 16.83 10.55 47 139768 3935 31553594
Disorientation 16.80 10.55 74 139741 30670 31526859
Diastolic hypotension 16.78 10.55 7 139808 48 31557481
Prostatic specific antigen increased 16.77 10.55 21 139794 13517 31544012
Venoocclusive liver disease 16.76 10.55 71 139744 7341 31550188
Infective pulmonary exacerbation of cystic fibrosis 16.73 10.55 4 139811 6480 31551049
Henoch-Schonlein purpura 16.73 10.55 27 139788 1538 31555991
Pulmonary hypertension 16.69 10.55 40 139775 20001 31537528
Skin discolouration 16.59 10.55 29 139786 16278 31541251
Mean cell haemoglobin increased 16.54 10.55 25 139790 1345 31556184
Lymphangitis 16.53 10.55 16 139799 537 31556992
Escherichia sepsis 16.46 10.55 48 139767 4119 31553410
Faeces discoloured 16.45 10.55 22 139793 13764 31543765
Gynaecomastia 16.42 10.55 10 139805 9144 31548385
Injection site mass 16.41 10.55 3 139812 5861 31551668
Intravascular haemolysis 16.40 10.55 14 139801 398 31557131
Aspiration 16.33 10.55 14 139801 10732 31546797
Sudden death 16.32 10.55 24 139791 14433 31543096
Autoimmune hepatitis 16.30 10.55 46 139769 3874 31553655
Gastritis fungal 16.26 10.55 8 139807 84 31557445
Bacterial infection 16.19 10.55 110 139705 13629 31543900
Body temperature decreased 16.19 10.55 98 139717 11672 31545857
Shock haemorrhagic 16.13 10.55 88 139727 10089 31547440
Glucose-6-phosphate dehydrogenase deficiency 16.10 10.55 9 139806 125 31557404
Exposure during pregnancy 15.98 10.55 9 139806 8589 31548940
Meningitis bacterial 15.98 10.55 23 139792 1184 31556345
Diaphragmatic injury 15.97 10.55 9 139806 127 31557402
Cutaneous malacoplakia 15.97 10.55 7 139808 55 31557474
Morganella infection 15.96 10.55 15 139800 485 31557044
Dystonia 15.93 10.55 13 139802 10212 31547317
Immune thrombocytopenia 15.92 10.55 77 139738 8421 31549108
Subcutaneous emphysema 15.89 10.55 22 139793 1092 31556437
Klebsiella sepsis 15.88 10.55 29 139786 1826 31555703
B-lymphocyte count decreased 15.87 10.55 16 139799 565 31556964
Herpes simplex hepatitis 15.86 10.55 8 139807 89 31557440
Blood lactate dehydrogenase increased 15.81 10.55 148 139667 20191 31537338
Angina pectoris 15.80 10.55 72 139743 29569 31527960
Withdrawal syndrome 15.79 10.55 17 139798 11700 31545829
Total lung capacity abnormal 15.73 10.55 9 139806 131 31557398
Cutaneous nocardiosis 15.67 10.55 9 139806 132 31557397
Mucosal ulceration 15.65 10.55 20 139795 918 31556611
Ageusia 15.65 10.55 11 139804 9320 31548209
Status asthmaticus 15.64 10.55 12 139803 292 31557237
Injection site pruritus 15.64 10.55 4 139811 6190 31551339
Epstein-Barr virus associated lymphoma 15.64 10.55 17 139798 656 31556873
Lymphocele 15.60 10.55 24 139791 1312 31556217
Eosinophil percentage decreased 15.55 10.55 8 139807 93 31557436
Stress 15.54 10.55 57 139758 24884 31532645
Arrhythmia 15.54 10.55 84 139731 32993 31524536
Flushing 15.49 10.55 202 139613 29926 31527603
Thyrotoxic periodic paralysis 15.48 10.55 8 139807 94 31557435
Urobilinogen urine increased 15.46 10.55 13 139802 362 31557167
Haemolysis 15.45 10.55 68 139747 7148 31550381
Mean cell haemoglobin concentration decreased 15.41 10.55 22 139793 1124 31556405
Stenotrophomonas infection 15.38 10.55 29 139786 1871 31555658
Urinoma 15.35 10.55 10 139805 186 31557343
Nocturia 15.34 10.55 11 139804 9224 31548305
Multi-organ disorder 15.31 10.55 22 139793 1131 31556398
Middle insomnia 15.28 10.55 4 139811 6095 31551434
Cystitis viral 15.27 10.55 15 139800 513 31557016
Cytomegalovirus gastrointestinal infection 15.25 10.55 10 139805 188 31557341
Microscopic polyangiitis 15.25 10.55 10 139805 188 31557341
Tardive dyskinesia 15.22 10.55 3 139812 5556 31551973
Encephalitis 15.19 10.55 65 139750 6750 31550779
Eczema 15.16 10.55 28 139787 15389 31542140
Fungal endocarditis 15.16 10.55 12 139803 306 31557223
Necrosis 15.08 10.55 54 139761 5162 31552367
Angiocentric lymphoma 15.06 10.55 12 139803 309 31557220
Arterial spasm 15.04 10.55 8 139807 100 31557429
Exophthalmos 15.03 10.55 15 139800 523 31557006
Stupor 15.00 10.55 36 139779 2748 31554781
Post procedural urine leak 14.99 10.55 9 139806 144 31557385
Urine leukocyte esterase positive 14.92 10.55 14 139801 452 31557077
Muscle rigidity 14.91 10.55 13 139802 9884 31547645
Presyncope 14.90 10.55 34 139781 17294 31540235
Glomerulonephritis minimal lesion 14.89 10.55 14 139801 453 31557076
Medication error 14.89 10.55 51 139764 22721 31534808
Venoocclusive disease 14.88 10.55 35 139780 2637 31554892
Cataract subcapsular 14.87 10.55 13 139802 382 31557147
Bifidobacterium infection 14.81 10.55 5 139810 17 31557512
Pleural mass 14.79 10.55 7 139808 67 31557462
Intestine transplant rejection 14.78 10.55 6 139809 38 31557491
Nervous system neoplasm 14.78 10.55 9 139806 148 31557381
Microsporidia infection 14.75 10.55 16 139799 616 31556913
Retinal detachment 14.74 10.55 52 139763 4934 31552595
Product administration error 14.72 10.55 28 139787 15219 31542310
Therapy interrupted 14.69 10.55 15 139800 10581 31546948
Heart rate increased 14.69 10.55 259 139556 40851 31516678
Pulmonary arterial hypertension 14.68 10.55 13 139802 9808 31547721
Device leakage 14.66 10.55 3 139812 5410 31552119
Pseudopolyposis 14.65 10.55 6 139809 39 31557490
Neuromyotonia 14.65 10.55 6 139809 39 31557490
Pneumonia influenzal 14.64 10.55 24 139791 1385 31556144
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids 14.59 10.55 5 139810 18 31557511
Neutrophil count increased 14.59 10.55 119 139696 15612 31541917
Urinary fistula 14.51 10.55 8 139807 108 31557421
Drug dependence 14.47 10.55 51 139764 22528 31535001
Intestinal ulcer 14.47 10.55 18 139797 804 31556725
Bilirubin urine present 14.46 10.55 9 139806 154 31557375
IVth nerve paralysis 14.44 10.55 8 139807 109 31557420
Uraemic encephalopathy 14.43 10.55 11 139804 265 31557264
Dermatomyositis 14.43 10.55 22 139793 1193 31556336
Graft infection 14.42 10.55 13 139802 398 31557131
Endocarditis 14.31 10.55 59 139756 6026 31551503
Pseudomonal bacteraemia 14.31 10.55 22 139793 1202 31556327
Wolff-Parkinson-White syndrome 14.30 10.55 10 139805 210 31557319
Arteriosclerosis coronary artery 14.29 10.55 17 139798 11191 31546338
Arterial rupture 14.25 10.55 14 139801 479 31557050
Treatment failure 14.22 10.55 256 139559 40536 31516993
Gastrointestinal ulcer 14.21 10.55 26 139789 1639 31555890
Herpes zoster meningoencephalitis 14.19 10.55 11 139804 272 31557257
Mycotic endophthalmitis 14.18 10.55 7 139808 74 31557455
Pleuropericarditis 14.13 10.55 10 139805 214 31557315
Epistaxis 14.13 10.55 160 139655 53547 31503982
Needle issue 14.12 10.55 3 139812 5270 31552259
Hepatic cirrhosis 14.10 10.55 30 139785 15644 31541885
Marrow hyperplasia 14.08 10.55 20 139795 1017 31556512
Blood immunoglobulin M decreased 14.08 10.55 13 139802 411 31557118
Head injury 14.07 10.55 33 139782 16625 31540904
Pneumonia necrotising 14.03 10.55 15 139800 568 31556961
Atrioventricular block first degree 13.93 10.55 4 139811 5733 31551796
Splenic necrosis 13.93 10.55 6 139809 45 31557484
Haematopoietic stem cell mobilisation 13.88 10.55 9 139806 166 31557363
Abnormal behaviour 13.86 10.55 56 139759 23772 31533757
Trichophytosis 13.85 10.55 11 139804 282 31557247
Abdominal compartment syndrome 13.84 10.55 18 139797 841 31556688
Cytomegalovirus nephritis 13.83 10.55 8 139807 119 31557410
Smooth muscle cell neoplasm 13.83 10.55 9 139806 167 31557362
Lung neoplasm malignant 13.83 10.55 32 139783 16198 31541331
Reversible cerebral vasoconstriction syndrome 13.80 10.55 12 139803 350 31557179
Haemoglobinuria 13.79 10.55 15 139800 579 31556950
Alopecia 13.77 10.55 46 139769 20649 31536880
Heart rate irregular 13.74 10.55 109 139706 14180 31543349
Limbic encephalitis 13.74 10.55 13 139802 424 31557105
Disseminated varicella zoster vaccine virus infection 13.71 10.55 6 139809 47 31557482
Eye luxation 13.70 10.55 4 139811 7 31557522
Anuria 13.68 10.55 82 139733 9732 31547797
Blood immunoglobulin G decreased 13.63 10.55 22 139793 1253 31556276
Abscess sterile 13.63 10.55 5 139810 23 31557506
Encephalitis cytomegalovirus 13.57 10.55 14 139801 508 31557021
Hepatitis cholestatic 13.57 10.55 65 139750 7081 31550448
Hepatic artery occlusion 13.56 10.55 7 139808 82 31557447
Gastrointestinal perforation 13.55 10.55 41 139774 3591 31553938
Pneumocephalus 13.55 10.55 8 139807 124 31557405
Type 2 diabetes mellitus 13.54 10.55 28 139787 14756 31542773
Epstein-Barr virus test positive 13.53 10.55 14 139801 510 31557019
Seronegative arthritis 13.51 10.55 19 139796 957 31556572
Nephritis 13.50 10.55 30 139785 2177 31555352
Brain herniation 13.50 10.55 42 139773 3735 31553794
Knee arthroplasty 13.49 10.55 6 139809 6552 31550977
Acinetobacter test positive 13.49 10.55 8 139807 125 31557404
Cardiomegaly 13.49 10.55 27 139788 14398 31543131
Loss of consciousness 13.48 10.55 250 139565 77105 31480424
Back disorder 13.47 10.55 5 139810 6088 31551441
Vision blurred 13.47 10.55 119 139696 41796 31515733
Trichosporon infection 13.47 10.55 16 139799 681 31556848
Kaposi's sarcoma 13.46 10.55 18 139797 864 31556665
Hypocomplementaemia 13.46 10.55 5 139810 24 31557505
Aplasia 13.45 10.55 45 139770 4158 31553371
Necrotising oesophagitis 13.44 10.55 14 139801 514 31557015
Muscle twitching 13.41 10.55 10 139805 8220 31549309
Therapeutic product effect decreased 13.41 10.55 83 139732 31539 31525990
Chimerism 13.40 10.55 10 139805 233 31557296
Steroid withdrawal syndrome 13.40 10.55 10 139805 233 31557296
Urine ketone body present 13.40 10.55 20 139795 1064 31556465
Papillitis 13.39 10.55 6 139809 50 31557479
Flatulence 13.38 10.55 41 139774 18907 31538622
Colitis 13.38 10.55 217 139598 33670 31523859
Bacterial test positive 13.37 10.55 36 139779 2950 31554579
Optic nerve compression 13.35 10.55 4 139811 8 31557521
Pulmonary fibrosis 13.34 10.55 122 139693 16538 31540991
Enterococcus test positive 13.33 10.55 17 139798 779 31556750
Spermatozoa progressive motility decreased 13.32 10.55 8 139807 128 31557401
Arteritis coronary 13.29 10.55 6 139809 51 31557478
Liver function test 13.29 10.55 6 139809 51 31557478
Chronic papillomatous dermatitis 13.29 10.55 6 139809 51 31557478
Blood potassium increased 13.28 10.55 30 139785 15315 31542214
Familial periodic paralysis 13.27 10.55 7 139808 86 31557443
Rib fracture 13.26 10.55 24 139791 13292 31544237
Hepatic cancer 13.26 10.55 9 139806 7766 31549763
Secondary immunodeficiency 13.22 10.55 12 139803 371 31557158
Surgery 13.19 10.55 22 139793 12577 31544952
Bundle branch block left 13.12 10.55 4 139811 5514 31552015
Bacterial pyelonephritis 13.08 10.55 10 139805 242 31557287
Therapeutic product effect prolonged 13.08 10.55 10 139805 242 31557287
Nephrolithiasis 13.08 10.55 69 139746 27270 31530259
Specific gravity urine decreased 13.06 10.55 7 139808 89 31557440
Campylobacter gastroenteritis 13.06 10.55 17 139798 795 31556734
Glycosylated haemoglobin increased 13.02 10.55 16 139799 10384 31547145
Sexual dysfunction 13.02 10.55 5 139810 5963 31551566
Hypoxia 12.99 10.55 302 139513 50011 31507518
Deep vein thrombosis 12.99 10.55 189 139626 60547 31496982
Eschar 12.88 10.55 15 139800 625 31556904
Acute hepatic failure 12.87 10.55 99 139716 12760 31544769
Arthritis fungal 12.86 10.55 7 139808 92 31557437
Bacterial translocation 12.85 10.55 11 139804 314 31557215
Type I hypersensitivity 12.80 10.55 20 139795 1108 31556421
Electrocardiogram abnormal 12.79 10.55 10 139805 8026 31549503
Dermatophytosis 12.77 10.55 10 139805 251 31557278
Central nervous system vasculitis 12.76 10.55 13 139802 465 31557064
Glomerulonephritis rapidly progressive 12.74 10.55 14 139801 547 31556982
Fungal disease carrier 12.74 10.55 10 139805 252 31557277
Coma 12.71 10.55 118 139697 41032 31516497
Kidney rupture 12.71 10.55 9 139806 193 31557336
Hip fracture 12.64 10.55 18 139797 10968 31546561
Demyelination 12.61 10.55 35 139780 2920 31554609
Donor specific antibody present 12.60 10.55 7 139808 96 31557433
Biopsy lymph gland 12.53 10.55 6 139809 59 31557470
Capnocytophaga infection 12.53 10.55 6 139809 59 31557470
Diffuse mesangial sclerosis 12.53 10.55 6 139809 59 31557470
Syringe issue 12.52 10.55 3 139812 4853 31552676
Paraplegia 12.49 10.55 33 139782 2674 31554855
Tularaemia 12.47 10.55 7 139808 98 31557431
Panic attack 12.44 10.55 12 139803 8691 31548838
Leishmaniasis 12.42 10.55 11 139804 329 31557200
Lower gastrointestinal haemorrhage 12.39 10.55 12 139803 8677 31548852
Seizure 12.39 10.55 340 139475 99428 31458101
Acanthamoeba keratitis 12.35 10.55 7 139808 100 31557429
Glomerulonephropathy 12.31 10.55 9 139806 203 31557326
Restlessness 12.30 10.55 57 139758 23304 31534225
Bilirubin conjugated increased 12.23 10.55 36 139779 3105 31554424
Capillaritis 12.23 10.55 7 139808 102 31557427
Acute kidney injury 12.22 10.55 1065 138750 278649 31278880
Schizophrenia 12.21 10.55 18 139797 10812 31546717
Device related sepsis 12.20 10.55 33 139782 2711 31554818
Peliosis hepatis 12.19 10.55 6 139809 63 31557466
Renal necrosis 12.18 10.55 8 139807 151 31557378
Adenomatous polyposis coli 12.18 10.55 8 139807 151 31557378
Malacoplakia gastrointestinal 12.17 10.55 7 139808 103 31557426
Removal of renal transplant 12.15 10.55 5 139810 33 31557496
Scedosporium infection 12.14 10.55 17 139798 853 31556676
Rectal haemorrhage 12.14 10.55 102 139713 36202 31521327
Emotional disorder 12.13 10.55 4 139811 5245 31552284
Pericarditis fungal 12.13 10.55 8 139807 152 31557377
Mood swings 12.13 10.55 9 139806 7415 31550114
Retching 12.11 10.55 6 139809 6155 31551374
Band neutrophil percentage increased 12.11 10.55 7 139808 104 31557425
Hepatic function abnormal 12.09 10.55 252 139563 40970 31516559
Perforation 12.09 10.55 9 139806 209 31557320
Dysarthria 12.09 10.55 87 139728 31930 31525599
Toxoplasmosis 12.03 10.55 21 139794 1276 31556253
Conus medullaris syndrome 12.02 10.55 5 139810 34 31557495
Pneumonia adenoviral 12.01 10.55 11 139804 344 31557185
Erythema infectiosum 11.99 10.55 8 139807 155 31557374
Inadequate aseptic technique in use of product 11.98 10.55 4 139811 13 31557516
Herpes simplex meningoencephalitis 11.98 10.55 4 139811 13 31557516
Blindness cortical 11.96 10.55 11 139804 346 31557183
Infective tenosynovitis 11.95 10.55 6 139809 66 31557463
Throat tightness 11.94 10.55 66 139749 7603 31549926
Norovirus infection 11.87 10.55 6 139809 67 31557462
Viral load abnormal 11.87 10.55 6 139809 67 31557462
Autoimmune colitis 11.86 10.55 18 139797 972 31556557
Tachypnoea 11.86 10.55 118 139697 16365 31541164
Aspergillus test positive 11.85 10.55 12 139803 426 31557103
Substance-induced psychotic disorder 11.85 10.55 23 139792 1517 31556012
Retinal pigment epitheliopathy 11.84 10.55 9 139806 216 31557313
Lipoma 11.81 10.55 23 139792 1520 31556009
Post procedural bile leak 11.81 10.55 10 139805 281 31557248
Haemoperitoneum 11.81 10.55 24 139791 1637 31555892
Multiple-drug resistance 11.80 10.55 45 139770 4435 31553094
Muscle abscess 11.79 10.55 13 139802 510 31557019
Retinal scar 11.78 10.55 10 139805 282 31557247
Acne fulminans 11.77 10.55 9 139806 218 31557311
Herpes simplex colitis 11.76 10.55 4 139811 14 31557515
Human ehrlichiosis 11.73 10.55 9 139806 219 31557310
Infection masked 11.72 10.55 6 139809 69 31557460
Coombs positive haemolytic anaemia 11.72 10.55 16 139799 784 31556745
Vitamin B1 decreased 11.69 10.55 10 139805 285 31557244
Cavernous sinus thrombosis 11.69 10.55 8 139807 162 31557367
Chronic kidney disease 11.68 10.55 109 139706 37866 31519663
Meningoencephalitis herpetic 11.67 10.55 16 139799 787 31556742
Hypoacusis 11.66 10.55 31 139784 14968 31542561
Poikiloderma 11.65 10.55 8 139807 163 31557366
Growth retardation 11.60 10.55 24 139791 1658 31555871
Haemodialysis 11.58 10.55 80 139735 9965 31547564
Palatal ulcer 11.55 10.55 5 139810 38 31557491
Parkinsonism 11.54 10.55 10 139805 7626 31549903
Herpes zoster cutaneous disseminated 11.52 10.55 8 139807 166 31557363
Sarcopenia 11.52 10.55 11 139804 363 31557166
Dehiscence 11.50 10.55 6 139809 72 31557457
Cardiac arrest 11.45 10.55 302 139513 88760 31468769
Arterial thrombosis 11.43 10.55 22 139793 1442 31556087
Visceral leishmaniasis 11.42 10.55 13 139802 528 31557001
Coombs direct test positive 11.41 10.55 10 139805 295 31557234
Anti-neutrophil cytoplasmic antibody positive vasculitis 11.39 10.55 16 139799 805 31556724
Phaeochromocytoma 11.36 10.55 8 139807 170 31557359
Carotid artery insufficiency 11.35 10.55 4 139811 16 31557513
Cerebral venous sinus thrombosis 11.34 10.55 12 139803 449 31557080
Radiotherapy to brain 11.33 10.55 5 139810 40 31557489
Tongue fungal infection 11.33 10.55 5 139810 40 31557489
Arteriovenous fistula 11.33 10.55 18 139797 1012 31556517
Hepatitis B 11.28 10.55 53 139762 5728 31551801
Inappropriate schedule of product administration 11.27 10.55 157 139658 50666 31506863
Body height below normal 11.26 10.55 9 139806 233 31557296
Macrophage activation 11.22 10.55 3 139812 3 31557526
Neonatal multi-organ failure 11.22 10.55 3 139812 3 31557526
Renal haemorrhage 11.20 10.55 21 139794 1349 31556180
Lymphocytic infiltration 11.19 10.55 14 139801 629 31556900
Right ventricular failure 11.17 10.55 12 139803 8270 31549259
Band neutrophil count increased 11.16 10.55 9 139806 236 31557293
Impaired work ability 11.14 10.55 6 139809 5871 31551658
Drug level below therapeutic 11.14 10.55 48 139767 5000 31552529
Retinal vasculitis 11.13 10.55 11 139804 379 31557150
Idiopathic pneumonia syndrome 11.13 10.55 9 139806 237 31557292
Amoebic dysentery 11.12 10.55 5 139810 42 31557487
Polyomavirus viraemia 11.11 10.55 15 139800 727 31556802
pH urine increased 11.08 10.55 6 139809 78 31557451
C-reactive protein increased 11.05 10.55 287 139528 48363 31509166
Pancreas transplant rejection 11.04 10.55 8 139807 178 31557351
Inflammatory marker increased 11.03 10.55 42 139773 4136 31553393
Aortic pseudoaneurysm 11.02 10.55 5 139810 43 31557486
Glucose tolerance impaired 10.98 10.55 33 139782 2879 31554650
Osteomyelitis blastomyces 10.97 10.55 4 139811 18 31557511
Nodular regenerative hyperplasia 10.97 10.55 17 139798 935 31556594
Gastrooesophageal reflux disease 10.95 10.55 96 139719 33775 31523754
Hepatitis 10.95 10.55 147 139668 21919 31535610
Libido decreased 10.94 10.55 3 139812 4433 31553096
Product dispensing error 10.90 10.55 6 139809 5798 31551731
Pulmonary cavitation 10.89 10.55 16 139799 839 31556690
Second primary malignancy 10.88 10.55 9 139806 7023 31550506
Abdominal infection 10.86 10.55 22 139793 1497 31556032
Computerised tomogram thorax abnormal 10.85 10.55 14 139801 649 31556880
Citrobacter infection 10.83 10.55 12 139803 473 31557056
Candida pneumonia 10.83 10.55 10 139805 316 31557213
Joint swelling 10.83 10.55 168 139647 53263 31504266
Cholestasis 10.82 10.55 163 139652 24912 31532617
Bradyphrenia 10.82 10.55 3 139812 4401 31553128
Inhibin B 10.80 10.55 4 139811 19 31557510
Atypical mycobacterial infection 10.78 10.55 15 139800 748 31556781
Vena cava thrombosis 10.78 10.55 18 139797 1055 31556474
Self-induced vomiting 10.76 10.55 3 139812 4 31557525
Delusion 10.76 10.55 23 139792 11974 31545555
Palpitations 10.75 10.55 99 139716 34484 31523045
Protein urine 10.74 10.55 16 139799 850 31556679
Urinary sediment present 10.74 10.55 8 139807 186 31557343
Diabetic hyperosmolar coma 10.74 10.55 11 139804 396 31557133
Hypoaesthesia 10.73 10.55 178 139637 55844 31501685
Rash papulosquamous 10.73 10.55 5 139810 46 31557483
Investigation abnormal 10.71 10.55 12 139803 479 31557050
Osteonecrosis of jaw 10.65 10.55 39 139776 17032 31540497
Hilar lymphadenopathy 10.64 10.55 16 139799 857 31556672
Infective aortitis 10.63 10.55 4 139811 20 31557509
Fungal peritonitis 10.63 10.55 15 139800 758 31556771
Encephalitis brain stem 10.63 10.55 6 139809 85 31557444
ADAMTS13 activity decreased 10.63 10.55 6 139809 85 31557444
Urinary tract infection bacterial 10.62 10.55 22 139793 1521 31556008
Aspergilloma 10.60 10.55 10 139805 325 31557204
Gastroenteritis rotavirus 10.59 10.55 8 139807 190 31557339
Mental impairment 10.59 10.55 16 139799 9516 31548013

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 1455.29 9.45 6889 312201 736171 69873183
Cytomegalovirus infection 1380.54 9.45 1260 317830 38498 70570856
Product use in unapproved indication 921.19 9.45 2521 316569 204957 70404397
Completed suicide 880.53 9.45 32 319058 227103 70382251
Infusion related reaction 774.21 9.45 2295 316795 195239 70414115
Drug ineffective for unapproved indication 754.81 9.45 899 318191 37639 70571715
Transplant rejection 636.63 9.45 579 318511 17592 70591762
Blood pressure fluctuation 559.64 9.45 975 318115 58037 70551317
Toxicity to various agents 545.73 9.45 549 318541 381623 70227731
Death 527.65 9.45 930 318160 509131 70100223
Drug abuse 513.62 9.45 39 319051 147217 70462137
Bronchopulmonary aspergillosis 499.59 9.45 542 318548 20460 70588894
Aspergillus infection 494.56 9.45 500 318590 17368 70591986
Kidney transplant rejection 453.95 9.45 369 318721 9592 70599762
Blood pressure diastolic abnormal 449.63 9.45 445 318645 15059 70594295
Cytomegalovirus viraemia 446.33 9.45 391 318699 11294 70598060
Pneumocystis jirovecii pneumonia 445.69 9.45 611 318479 29471 70579883
Product dose omission issue 432.45 9.45 219 318871 217249 70392105
Multiple organ dysfunction syndrome 417.19 9.45 1253 317837 107262 70502092
Posterior reversible encephalopathy syndrome 414.49 9.45 530 318560 23872 70585482
Oxygen saturation decreased 413.80 9.45 1308 317782 115121 70494233
Mucormycosis 403.96 9.45 315 318775 7699 70601655
Lymphocyte count decreased 400.63 9.45 710 318380 42829 70566525
Drug ineffective 395.82 9.45 6169 312921 933583 69675771
Blood pressure systolic abnormal 386.42 9.45 377 318713 12532 70596822
Fall 382.88 9.45 899 318191 443197 70166157
Graft versus host disease 373.66 9.45 397 318693 14626 70594728
Thrombotic microangiopathy 372.07 9.45 430 318660 17418 70591936
Haemophagocytic lymphohistiocytosis 337.88 9.45 429 318661 19183 70590171
Urine abnormality 325.20 9.45 275 318815 7563 70601791
Blood pressure increased 324.45 9.45 1690 317400 186827 70422527
Epstein-Barr virus infection 323.35 9.45 346 318744 12852 70596502
Respiratory failure 319.47 9.45 1554 317536 167181 70442173
Intentional overdose 309.34 9.45 39 319051 98396 70510958
Polyomavirus-associated nephropathy 294.91 9.45 219 318871 4964 70604390
Complications of transplanted kidney 292.08 9.45 230 318860 5704 70603650
Graft versus host disease in gastrointestinal tract 287.45 9.45 228 318862 5716 70603638
Blood pressure systolic increased 287.31 9.45 729 318361 56530 70552824
Pneumatosis intestinalis 270.19 9.45 219 318871 5668 70603686
Post transplant lymphoproliferative disorder 268.18 9.45 282 318808 10263 70599091
BK virus infection 257.43 9.45 243 318847 7746 70601608
Heart rate decreased 252.44 9.45 731 318359 61284 70548070
Cytomegalovirus test positive 238.32 9.45 198 318892 5310 70604044
Steroid diabetes 234.59 9.45 154 318936 2843 70606511
Strongyloidiasis 233.83 9.45 167 318923 3556 70605798
Overdose 233.78 9.45 251 318839 169494 70439860
Red blood cells urine positive 232.81 9.45 183 318907 4526 70604828
Throat irritation 232.41 9.45 500 318590 34804 70574550
Cytomegalovirus infection reactivation 227.62 9.45 211 318879 6570 70602784
Adenovirus infection 225.30 9.45 223 318867 7545 70601809
Urine leukocyte esterase positive 223.19 9.45 161 318929 3484 70605870
Injection site pain 222.59 9.45 126 318964 117493 70491861
Septic shock 217.47 9.45 1041 318049 111217 70498137
Confusional state 211.69 9.45 619 318471 283779 70325575
Cardiac failure congestive 211.39 9.45 179 318911 135278 70474076
Glossodynia 209.74 9.45 64 319026 86423 70522931
Enterococcal infection 209.69 9.45 292 318798 14290 70595064
Synovitis 208.83 9.45 165 318925 129063 70480291
White blood cells urine positive 207.95 9.45 185 318905 5455 70603899
Pseudomonas infection 206.86 9.45 334 318756 18660 70590694
Nocardiosis 206.74 9.45 177 318913 4952 70604402
Urinary sediment present 201.95 9.45 128 318962 2219 70607135
Graft versus host disease in skin 196.40 9.45 179 318911 5451 70603903
Multiple sclerosis relapse 193.65 9.45 526 318564 42491 70566863
Lymphopenia 192.30 9.45 398 318692 26961 70582393
Syncope 190.66 9.45 281 318809 165428 70443926
Alopecia 187.86 9.45 381 318709 198109 70411245
Acute graft versus host disease in skin 187.11 9.45 194 318896 6943 70602411
Myocardial infarction 187.02 9.45 302 318788 171343 70438011
Hospitalisation 186.45 9.45 69 319021 82499 70526855
Crystal urine present 183.80 9.45 115 318975 1947 70607407
Acute graft versus host disease 178.86 9.45 218 318872 9344 70600010
Nausea 178.61 9.45 2730 316360 849358 69759996
Klebsiella infection 177.50 9.45 267 318823 14025 70595329
Lymphocyte percentage decreased 176.68 9.45 157 318933 4622 70604732
Dehydration 175.75 9.45 482 318608 225660 70383694
Suicide attempt 175.28 9.45 69 319021 79441 70529913
Dizziness 174.92 9.45 1296 317794 462845 70146509
Neutrophil percentage increased 173.48 9.45 152 318938 4390 70604964
Delayed graft function 173.02 9.45 133 318957 3180 70606174
Pneumonia cytomegaloviral 172.93 9.45 152 318938 4409 70604945
Acute respiratory distress syndrome 172.43 9.45 491 318599 40763 70568591
Blood pressure diastolic decreased 171.85 9.45 367 318723 25413 70583941
Wrong technique in product usage process 169.92 9.45 49 319041 68649 70540705
Vomiting 169.76 9.45 1778 317312 591333 70018021
Progressive multifocal leukoencephalopathy 168.61 9.45 307 318783 18907 70590447
Diarrhoea 167.07 9.45 2501 316589 780840 69828514
Pneumomediastinum 166.68 9.45 131 318959 3239 70606115
Disseminated intravascular coagulation 164.61 9.45 424 318666 33174 70576180
Candida infection 163.72 9.45 430 318660 34043 70575311
Human herpesvirus 6 infection 162.72 9.45 151 318939 4708 70604646
Erythema 162.16 9.45 1488 317602 198075 70411279
Abdominal discomfort 159.07 9.45 468 318622 214190 70395164
Urine analysis abnormal 157.25 9.45 165 318925 5989 70603365
Acute graft versus host disease in intestine 156.49 9.45 133 318957 3683 70605671
Fatigue 154.46 9.45 2696 316394 821623 69787731
Liver transplant rejection 153.20 9.45 120 318970 2952 70606402
Cystitis haemorrhagic 152.82 9.45 191 318899 8402 70600952
Heart rate increased 152.67 9.45 907 318183 105241 70504113
Drug intolerance 151.81 9.45 514 318576 225173 70384181
Sleep disorder due to general medical condition, insomnia type 145.85 9.45 3 319087 35729 70573625
Immunosuppressant drug level increased 145.84 9.45 179 318911 7728 70601626
Contraindicated product administered 145.52 9.45 238 318852 134374 70474980
Wound 145.00 9.45 138 318952 98594 70510760
Hypoglycaemia 144.40 9.45 127 318963 94237 70515117
Swelling 143.38 9.45 406 318684 188133 70421221
Arthropathy 142.83 9.45 287 318803 149770 70459584
Cerebrovascular accident 140.35 9.45 270 318820 143200 70466154
Injection site erythema 139.56 9.45 77 319013 72847 70536507
Irritable bowel syndrome 137.88 9.45 30 319060 50820 70558534
Muscle injury 137.60 9.45 9 319081 38485 70570869
Cytomegalovirus chorioretinitis 135.28 9.45 142 318948 5156 70604198
Cushingoid 134.33 9.45 177 318913 8211 70601143
Flushing 132.52 9.45 724 318366 81448 70527906
Serotonin syndrome 131.52 9.45 17 319073 42097 70567257
Mycobacterium chelonae infection 128.07 9.45 97 318993 2267 70607087
Constipation 127.86 9.45 642 318448 251796 70357558
Orthostatic hypotension 127.79 9.45 37 319053 51706 70557648
Red cell distribution width increased 127.25 9.45 224 318866 13433 70595921
Drug interaction 126.11 9.45 1103 317987 380338 70229016
Hand deformity 125.69 9.45 122 318968 86360 70522994
COVID-19 123.93 9.45 858 318232 104899 70504455
Peripheral swelling 123.62 9.45 595 318495 235968 70373386
Intentional product use issue 120.94 9.45 940 318150 119202 70490152
Rebound effect 119.67 9.45 141 318949 5830 70603524
Cytomegalovirus colitis 118.28 9.45 119 318971 4107 70605247
Pericarditis 116.84 9.45 125 318965 84580 70524774
Secondary immunodeficiency 115.02 9.45 99 318991 2790 70606564
Psoriasis 114.07 9.45 166 318924 98267 70511087
Oedema peripheral 113.27 9.45 584 318506 227507 70381847
Loss of personal independence in daily activities 113.05 9.45 129 318961 84781 70524573
Varicella zoster virus infection 111.64 9.45 114 318976 4006 70605348
Discomfort 111.55 9.45 189 318901 105247 70504107
International normalised ratio increased 110.38 9.45 120 318970 80606 70528748
Anti-cyclic citrullinated peptide antibody positive 110.37 9.45 92 318998 70093 70539261
Decreased appetite 109.92 9.45 861 318229 303919 70305435
Systemic mycosis 109.82 9.45 91 318999 2431 70606923
Intentional product misuse 109.18 9.45 118 318972 79477 70529877
Sedation 109.00 9.45 37 319053 46694 70562660
Bacterial test 108.49 9.45 68 319022 1155 70608199
Blood urine present 108.29 9.45 257 318833 19096 70590258
Hyponatraemia 108.01 9.45 364 318726 159723 70449631
Chorioretinopathy 106.84 9.45 85 319005 2140 70607214
Drug resistance 106.56 9.45 396 318694 37794 70571560
Pemphigus 106.43 9.45 130 318960 82906 70526448
Myopathy 105.06 9.45 248 318842 18364 70590990
Pain 104.04 9.45 2100 316990 626716 69982638
Enterobacter infection 103.99 9.45 109 318981 3951 70605403
Acinetobacter infection 103.20 9.45 89 319001 2515 70606839
Coronary artery disease 102.71 9.45 79 319011 62657 70546697
Blood pressure diastolic increased 102.46 9.45 193 318897 12198 70597156
Leukopenia 102.45 9.45 825 318265 105735 70503619
Duodenal ulcer perforation 102.19 9.45 51 319039 51061 70558293
Asthenia 102.17 9.45 1447 317643 456219 70153135
Pyrexia 101.91 9.45 3506 315584 603446 70005908
Osteonecrosis 101.09 9.45 325 318765 28835 70580519
Focal segmental glomerulosclerosis 100.46 9.45 96 318994 3108 70606246
Acute graft versus host disease in liver 100.35 9.45 75 319015 1717 70607637
Parvovirus B19 infection 99.98 9.45 67 319023 1282 70608072
Feeling hot 99.05 9.45 458 318632 48212 70561142
Pulmonary mucormycosis 98.51 9.45 59 319031 920 70608434
Bacterial test positive 98.42 9.45 139 318951 6892 70602462
Plasma cell myeloma 97.68 9.45 111 318979 73090 70536264
Protein urine present 97.38 9.45 162 318928 9278 70600076
Pulmonary alveolar haemorrhage 96.51 9.45 170 318920 10199 70599155
Accidental exposure to product 96.15 9.45 8 319082 28043 70581311
Drug effective for unapproved indication 95.47 9.45 111 318979 4524 70604830
Vasculitis 94.95 9.45 246 318844 19312 70590042
Urine ketone body present 94.30 9.45 95 318995 3284 70606070
Injection site swelling 94.21 9.45 38 319052 43119 70566235
Intentional self-injury 93.65 9.45 15 319075 31635 70577719
Chronic graft versus host disease 92.05 9.45 132 318958 6638 70602716
Staphylococcal sepsis 91.63 9.45 193 318897 13234 70596120
Rhabdomyolysis 91.22 9.45 183 318907 95577 70513777
Disease recurrence 91.16 9.45 373 318717 37230 70572124
Diffuse alveolar damage 91.02 9.45 93 318997 3270 70606084
Epstein-Barr virus associated lymphoproliferative disorder 90.93 9.45 92 318998 3197 70606157
Herpes simplex 90.47 9.45 173 318917 11059 70598295
Helicobacter infection 89.95 9.45 71 319019 55585 70553769
Anaphylactic shock 89.90 9.45 336 318754 32154 70577200
Escherichia infection 89.36 9.45 215 318875 16116 70593238
Granulomatosis with polyangiitis 89.34 9.45 82 319008 2520 70606834
Reversible cerebral vasoconstriction syndrome 89.06 9.45 83 319007 2602 70606752
Product prescribing error 88.86 9.45 32 319058 38920 70570434
Ear pruritus 88.78 9.45 88 319002 2982 70606372
Hyperglycaemia 88.75 9.45 546 318544 64126 70545228
Nephropathy toxic 87.97 9.45 231 318859 18283 70591071
Psoriatic arthropathy 86.66 9.45 98 318992 64673 70544681
Stomatitis 86.13 9.45 293 318797 128218 70481136
Accidental overdose 85.11 9.45 26 319064 35095 70574259
General physical health deterioration 84.95 9.45 667 318423 235364 70373990
Haemoglobin urine present 84.01 9.45 51 319039 816 70608538
Device expulsion 83.22 9.45 4 319086 22242 70587112
Cytomegalovirus enteritis 83.18 9.45 48 319042 696 70608658
Culture urine positive 83.17 9.45 99 318991 4138 70605216
COVID-19 pneumonia 82.74 9.45 252 318838 21717 70587637
Bacterial sepsis 82.62 9.45 134 318956 7513 70601841
Encephalitis autoimmune 82.46 9.45 73 319017 2138 70607216
Rheumatoid factor positive 81.74 9.45 59 319031 48341 70561013
Renal transplant failure 81.62 9.45 66 319024 1702 70607652
Monocyte percentage increased 81.26 9.45 70 319020 1975 70607379
Lupus nephritis 81.04 9.45 81 319009 2773 70606581
Diabetes mellitus 79.62 9.45 575 318515 71249 70538105
Chronic allograft nephropathy 79.47 9.45 62 319028 1516 70607838
C-reactive protein abnormal 79.40 9.45 37 319053 38542 70570812
Injection site pruritus 78.57 9.45 39 319051 39171 70570183
Infection reactivation 78.02 9.45 73 319017 2300 70607054
Viral haemorrhagic cystitis 77.51 9.45 65 319025 1766 70607588
Serum sickness 77.31 9.45 85 319005 3256 70606098
Pseudomonal sepsis 76.82 9.45 109 318981 5428 70603926
Injection site bruising 75.95 9.45 38 319052 37994 70571360
Disseminated mucormycosis 75.33 9.45 43 319047 610 70608744
Therapy non-responder 75.28 9.45 598 318492 76317 70533037
Transient ischaemic attack 75.02 9.45 58 319032 45886 70563468
Viraemia 74.99 9.45 73 319017 2419 70606935
Sepsis 74.74 9.45 1529 317561 243016 70366338
Cryptococcosis 74.50 9.45 83 319007 3227 70606127
Sopor 74.25 9.45 24 319066 31243 70578111
Neutrophil count increased 74.05 9.45 277 318813 26518 70582836
Adverse event 73.94 9.45 68 319022 49393 70559961
Systemic candida 73.89 9.45 111 318979 5823 70603531
Contusion 73.44 9.45 311 318779 127725 70481629
Pneumocystis jirovecii infection 72.52 9.45 73 319017 2521 70606833
Temperature regulation disorder 71.51 9.45 94 318996 4350 70605004
Intensive care unit acquired weakness 71.14 9.45 61 319029 1710 70607644
Cytokine release syndrome 70.98 9.45 271 318819 26196 70583158
Proteinuria 70.91 9.45 291 318799 29083 70580271
Nephrotic syndrome 70.36 9.45 151 318939 10489 70598865
Specific gravity urine decreased 70.21 9.45 45 319045 796 70608558
Fungal infection 70.01 9.45 344 318746 37123 70572231
Product quality issue 69.89 9.45 25 319065 30536 70578818
Cytomegalovirus enterocolitis 69.82 9.45 56 319034 1427 70607927
Dural arteriovenous fistula 69.70 9.45 21 319069 42 70609312
Immunodeficiency 69.54 9.45 205 318885 17350 70592004
Opportunistic infection 69.27 9.45 73 319017 2663 70606691
Febrile bone marrow aplasia 69.01 9.45 161 318929 11830 70597524
Pharyngeal paraesthesia 68.32 9.45 66 319024 2166 70607188
Hypertension 67.60 9.45 1777 317313 294256 70315098
Dyspnoea 67.20 9.45 2808 316282 767252 69842102
Renal tubular atrophy 65.93 9.45 58 319032 1684 70607670
Mycobacterium abscessus infection 65.58 9.45 51 319039 1241 70608113
Staphylococcal infection 65.35 9.45 438 318652 52966 70556388
Immunosuppressant drug level decreased 64.61 9.45 59 319031 1801 70607553
Necrotising retinitis 64.08 9.45 49 319041 1162 70608192
Systemic lupus erythematosus 63.84 9.45 239 318851 101663 70507691
Therapy cessation 63.79 9.45 36 319054 33640 70575714
Chest discomfort 63.40 9.45 846 318244 123535 70485819
Lethargy 63.29 9.45 154 318936 75096 70534258
JC virus infection 63.26 9.45 79 319011 3472 70605882
Folliculitis 63.07 9.45 59 319031 42511 70566843
Bacterial infection 62.80 9.45 261 318829 26231 70583123
Malignant neoplasm progression 62.49 9.45 308 318782 121431 70487923
Poisoning 62.03 9.45 13 319077 22609 70586745
Bacteraemia 62.00 9.45 279 318811 29030 70580324
Injection site reaction 61.84 9.45 80 319010 49772 70559582
Osteonecrosis of jaw 61.73 9.45 56 319034 40946 70568408
Respiratory rate increased 61.72 9.45 212 318878 19460 70589894
Human herpesvirus 8 infection 61.55 9.45 46 319044 1053 70608301
Device malfunction 61.32 9.45 7 319083 19077 70590277
Acute kidney injury 61.27 9.45 1646 317444 472978 70136376
Gastroenteritis norovirus 59.78 9.45 69 319021 2790 70606564
Device issue 59.65 9.45 17 319073 24008 70585346
Rhinocerebral mucormycosis 59.54 9.45 39 319051 717 70608637
Graft versus host disease in liver 59.50 9.45 53 319037 1565 70607789
Renal tubular necrosis 59.48 9.45 234 318856 22937 70586417
Immune thrombocytopenia 59.38 9.45 185 318905 16139 70593215
Nitrite urine present 58.92 9.45 46 319044 1126 70608228
Pain in extremity 58.87 9.45 1080 318010 327002 70282352
Hypophagia 58.83 9.45 60 319030 41510 70567844
Glomerulonephritis 58.70 9.45 72 319018 3106 70606248
Neuroleptic malignant syndrome 58.25 9.45 22 319068 25985 70583369
Depressed level of consciousness 58.12 9.45 200 318890 87231 70522123
Drug hypersensitivity 57.68 9.45 832 318258 261627 70347727
Knee arthroplasty 57.68 9.45 42 319048 34259 70575095
Systemic inflammatory response syndrome 57.51 9.45 140 318950 10572 70598782
Unresponsive to stimuli 56.86 9.45 91 318999 51840 70557514
Central nervous system infection 56.60 9.45 46 319044 1195 70608159
Corynebacterium infection 56.08 9.45 44 319046 1085 70608269
Adverse drug reaction 56.06 9.45 96 318994 53248 70556106
Suicidal ideation 55.76 9.45 146 318944 69450 70539904
Mobility decreased 55.54 9.45 256 318834 102743 70506611
Therapy interrupted 55.52 9.45 21 319069 24781 70584573
Haemolytic anaemia 55.35 9.45 184 318906 16610 70592744
Thrombocytopenia 55.33 9.45 1438 317652 237672 70371682
Full blood count abnormal 55.02 9.45 43 319047 33835 70575519
Multiple sclerosis 54.47 9.45 242 318848 25043 70584311
Cytomegalovirus oesophagitis 54.30 9.45 36 319054 676 70608678
Lower respiratory tract infection 54.12 9.45 289 318801 111624 70497730
Blister 54.12 9.45 250 318840 100276 70509078
Ureaplasma infection 54.01 9.45 37 319053 735 70608619
Electric shock 53.88 9.45 44 319046 1151 70608203
Premature delivery 53.77 9.45 214 318876 21090 70588264
Pneumonia cryptococcal 53.48 9.45 47 319043 1363 70607991
Specific gravity urine increased 53.15 9.45 30 319060 416 70608938
Listeriosis 52.84 9.45 55 319035 1977 70607377
Hypogammaglobulinaemia 52.83 9.45 142 318948 11396 70597958
Transplant failure 52.82 9.45 78 319012 4029 70605325
Prostate cancer 52.60 9.45 38 319052 31125 70578229
Pulmonary nocardiosis 52.41 9.45 38 319052 829 70608525
Perinephric abscess 51.61 9.45 24 319066 215 70609139
Atrial fibrillation 51.54 9.45 555 318535 183793 70425561
Respiratory arrest 51.41 9.45 103 318987 53830 70555524
Body temperature decreased 51.27 9.45 260 318830 28412 70580942
Candida sepsis 51.20 9.45 58 319032 2297 70607057
Red blood cell sedimentation rate abnormal 51.10 9.45 12 319078 19291 70590063
Neuromyelitis optica spectrum disorder 50.97 9.45 41 319049 1049 70608305
Infective aneurysm 50.62 9.45 38 319052 876 70608478
Dermatomyositis 50.58 9.45 70 319020 3405 70605949
Muscle spasms 50.54 9.45 446 318644 153600 70455754
Diffuse large B-cell lymphoma 50.48 9.45 153 318937 13149 70596205
Central nervous system fungal infection 50.47 9.45 29 319061 417 70608937
Herpes zoster 50.38 9.45 596 318494 84639 70524715
Substance-induced psychotic disorder 50.29 9.45 65 319025 2958 70606396
Blood thyroid stimulating hormone decreased 50.22 9.45 89 319001 5365 70603989
Pulmonary haemorrhage 49.78 9.45 155 318935 13518 70595836
Coma 49.68 9.45 228 318862 91616 70517738
Interstitial lung disease 49.66 9.45 703 318387 103982 70505372
Stenotrophomonas infection 49.55 9.45 68 319022 3281 70606073
Hyperkalaemia 49.49 9.45 279 318811 106312 70503042
Disseminated cryptococcosis 49.43 9.45 50 319040 1737 70607617
Malaise 48.90 9.45 1529 317561 431403 70177951
Gastrointestinal disorder 48.38 9.45 277 318813 105150 70504204
Sedation complication 48.33 9.45 3 319087 13407 70595947
Anaemia 47.96 9.45 1415 317675 402008 70207346
Amoebic colitis 47.83 9.45 18 319072 88 70609266
Bone pain 47.64 9.45 98 318992 50724 70558630
Full blood count decreased 47.60 9.45 24 319066 23894 70585460
Memory impairment 47.18 9.45 235 318855 92406 70516948
Human bocavirus infection 47.09 9.45 31 319059 575 70608779
Pleocytosis 46.96 9.45 42 319048 1247 70608107
Drug withdrawal syndrome 46.54 9.45 47 319043 32668 70576686
Toxoplasmosis 46.39 9.45 58 319032 2552 70606802
Glomerulosclerosis 46.22 9.45 37 319053 940 70608414
Joint swelling 46.19 9.45 831 318259 252380 70356974
Treatment noncompliance 46.08 9.45 87 319003 46487 70562867
Injection site haemorrhage 45.94 9.45 29 319061 25498 70583856
Demyelination 45.92 9.45 101 318989 7135 70602219
Kidney fibrosis 45.83 9.45 65 319025 3235 70606119
Aggression 45.77 9.45 93 318997 48353 70561001
Encephalitis cytomegalovirus 45.77 9.45 38 319052 1018 70608336
Therapeutic product effect decreased 45.64 9.45 417 318673 142601 70466753
Aplastic anaemia 45.52 9.45 172 318918 16544 70592810
Necrosis ischaemic 45.33 9.45 37 319053 967 70608387
Surgery 45.09 9.45 41 319049 29948 70579406
Pneumonia fungal 45.07 9.45 122 318968 9831 70599523
Sleep disorder 44.99 9.45 162 318928 69710 70539644
Acute myocardial infarction 44.96 9.45 172 318918 72715 70536639
Intra-abdominal pressure increased 44.80 9.45 22 319068 225 70609129
Large intestine perforation 44.77 9.45 146 318944 13049 70596305
Chest pain 44.45 9.45 829 318261 250431 70358923
Red blood cells urine 44.39 9.45 31 319059 636 70608718
Myalgia 44.33 9.45 512 318578 167380 70441974
Pulmonary hypertension 44.25 9.45 89 319001 46447 70562907
Haemolytic uraemic syndrome 44.12 9.45 72 319018 4058 70605296
Extrapyramidal disorder 44.11 9.45 19 319071 20731 70588623
Engraftment syndrome 43.72 9.45 40 319050 1224 70608130
Oral herpes 43.72 9.45 220 318870 23966 70585388
Intervertebral discitis 43.72 9.45 72 319018 4089 70605265
Injection site mass 43.69 9.45 14 319076 18329 70591025
Food allergy 43.22 9.45 109 318981 8415 70600939
Osteoarthritis 43.19 9.45 179 318911 73968 70535386
Impaired healing 43.04 9.45 180 318910 74194 70535160
Epstein-Barr virus infection reactivation 43.00 9.45 43 319047 1473 70607881
Feeling abnormal 42.83 9.45 421 318669 141898 70467456
Hepatocellular injury 42.73 9.45 354 318736 45737 70563617
Hallucination 42.63 9.45 187 318903 76073 70533281
Pneumonia pseudomonal 42.49 9.45 81 319009 5165 70604189
Encephalitis 42.27 9.45 146 318944 13439 70595915
Osteomyelitis fungal 42.04 9.45 22 319068 260 70609094
Pneumoretroperitoneum 41.76 9.45 19 319071 161 70609193
Urticaria 41.69 9.45 994 318096 162055 70447299
Pulmonary arterial hypertension 41.50 9.45 52 319038 32803 70576551
Pneumonia acinetobacter 41.44 9.45 18 319072 135 70609219
Epstein-Barr viraemia 41.20 9.45 47 319043 1876 70607478
West Nile viral infection 41.13 9.45 34 319056 905 70608449
Loss of consciousness 41.06 9.45 475 318615 155241 70454113
Product substitution issue 40.90 9.45 16 319074 18497 70590857
Mycoplasma infection 40.73 9.45 30 319060 671 70608683
Abdominal pain upper 40.68 9.45 619 318471 192983 70416371
Cardiac failure 40.57 9.45 431 318659 143110 70466244
Pedal pulse abnormal 40.40 9.45 19 319071 175 70609179
Central nervous system viral infection 40.25 9.45 16 319074 93 70609261
Labelled drug-drug interaction medication error 39.97 9.45 30 319060 24097 70585257
Respiratory distress 39.61 9.45 398 318692 54252 70555102
Lower limb fracture 39.60 9.45 13 319077 16759 70592595
Chills 39.59 9.45 891 318199 143895 70465459
Abscess bacterial 39.56 9.45 31 319059 763 70608591
Cerebral aspergillosis 39.47 9.45 44 319046 1712 70607642
Medication error 39.32 9.45 128 318962 56784 70552570
Blood calcium decreased 39.29 9.45 43 319047 28803 70580551
Segmental diverticular colitis 39.22 9.45 18 319072 156 70609198
Optic neuritis 39.21 9.45 108 318982 8792 70600562
Aplasia 39.18 9.45 95 318995 7156 70602198
Pathogen resistance 38.98 9.45 140 318950 13139 70596215
Gastrooesophageal reflux disease 38.87 9.45 244 318846 90595 70518759
Product storage error 38.57 9.45 9 319081 14532 70594822
Haemodynamic instability 38.48 9.45 156 318934 15502 70593852
Fusarium infection 38.24 9.45 43 319047 1689 70607665
Urinary casts 38.12 9.45 36 319054 1148 70608206
Band sensation 38.10 9.45 29 319061 683 70608671
Penicillium infection 38.02 9.45 20 319070 239 70609115
Pneumonia bacterial 37.93 9.45 162 318928 16479 70592875
Thyroxine free increased 37.89 9.45 36 319054 1157 70608197
Blood immunoglobulin M decreased 37.88 9.45 35 319055 1085 70608269
Disseminated tuberculosis 37.87 9.45 67 319023 4033 70605321
Pneumothorax 37.86 9.45 222 318868 25624 70583730
Steroid withdrawal syndrome 37.84 9.45 29 319061 690 70608664
Injection site warmth 37.79 9.45 8 319082 13817 70595537
Incision site pain 37.78 9.45 54 319036 2707 70606647
IgA nephropathy 37.55 9.45 41 319049 1558 70607796
Bilirubin urine present 37.53 9.45 22 319068 329 70609025
Ureteric stenosis 37.52 9.45 37 319053 1246 70608108
Poor venous access 37.47 9.45 150 318940 14821 70594533
Herpes virus infection 37.45 9.45 88 319002 6496 70602858
Device difficult to use 37.44 9.45 3 319087 10846 70598508
Cardiac disorder 37.43 9.45 139 318951 59276 70550078
Nightmare 37.42 9.45 27 319063 22129 70587225
Phaeohyphomycosis 37.32 9.45 35 319055 1106 70608248
Peritonitis 37.24 9.45 223 318867 25936 70583418
Lung abscess 36.96 9.45 63 319027 3681 70605673
Monocyte count increased 36.92 9.45 108 318982 9101 70600253
Epstein-Barr virus associated lymphoma 36.90 9.45 34 319056 1050 70608304
Miosis 36.87 9.45 9 319081 14092 70595262
Fungaemia 36.80 9.45 66 319024 4016 70605338
Underdose 36.60 9.45 47 319043 29336 70580018
Injection site rash 36.55 9.45 14 319076 16396 70592958
Steroid dependence 36.51 9.45 28 319062 667 70608687
Symptom masked 36.49 9.45 36 319054 1213 70608141
Coeliac disease 36.27 9.45 106 318984 8927 70600427
Oesophageal candidiasis 36.27 9.45 102 318988 8405 70600949
Skin striae 35.97 9.45 40 319050 1552 70607802
Sleep disorder due to a general medical condition 35.87 9.45 3 319087 10473 70598881
Neuralgia 35.83 9.45 236 318854 28367 70580987
Clostridium difficile colitis 35.58 9.45 238 318852 28758 70580596
Cardio-respiratory arrest 35.48 9.45 286 318804 100391 70508963
Prescribed overdose 35.41 9.45 42 319048 27139 70582215
Pain in jaw 35.34 9.45 88 319002 42581 70566773
Right ventricular failure 35.26 9.45 29 319061 22245 70587109
American trypanosomiasis 35.20 9.45 21 319069 325 70609029
Blood glucose decreased 35.18 9.45 34 319056 24125 70585229
Multiple-drug resistance 35.17 9.45 92 318998 7263 70602091
Shock haemorrhagic 35.09 9.45 168 318922 17938 70591416
Urobilinogen urine increased 35.00 9.45 27 319063 649 70608705
Abdominal infection 34.88 9.45 56 319034 3113 70606241
Status epilepticus 34.86 9.45 209 318881 24317 70585037
Complications of transplant surgery 34.86 9.45 28 319062 715 70608639
Torsade de pointes 34.84 9.45 19 319071 18097 70591257
Hip arthroplasty 34.77 9.45 45 319045 27995 70581359
Escherichia sepsis 34.70 9.45 93 318997 7450 70601904
Renal impairment 34.54 9.45 870 318220 143067 70466287
Quadriplegia 34.39 9.45 55 319035 3047 70606307
Gastroenteritis rotavirus 34.38 9.45 22 319068 388 70608966
Neurological decompensation 34.37 9.45 70 319020 4686 70604668
Rash erythematous 34.34 9.45 370 318720 51348 70558006
Hepatitis 34.32 9.45 360 318730 49620 70559734
Haematemesis 34.23 9.45 109 318981 48688 70560666
Immune effector cell-associated neurotoxicity syndrome 34.19 9.45 63 319027 3915 70605439
Necrotising herpetic retinopathy 34.14 9.45 15 319075 116 70609238
Cerebral venous thrombosis 34.14 9.45 49 319041 2466 70606888
Band neutrophil percentage increased 34.14 9.45 22 319068 393 70608961
Gait disturbance 33.89 9.45 607 318483 184499 70424855
Adenoviral hepatitis 33.73 9.45 29 319061 816 70608538
Tardive dyskinesia 33.57 9.45 3 319087 9926 70599428
Intestinal ischaemia 33.57 9.45 125 318965 11939 70597415
Pyelonephritis fungal 33.29 9.45 15 319075 124 70609230
Immune reconstitution inflammatory syndrome 33.19 9.45 131 318959 12859 70596495
Rectal haemorrhage 32.94 9.45 168 318922 65663 70543691
Feeding intolerance 32.90 9.45 26 319064 648 70608706
Pregnancy 32.89 9.45 35 319055 23746 70585608
Coronavirus infection 32.81 9.45 81 319009 6171 70603183
Mean cell haemoglobin concentration decreased 32.80 9.45 63 319027 4040 70605314
Brain abscess 32.76 9.45 67 319023 4499 70604855
Needle issue 32.68 9.45 5 319085 10910 70598444
Heart transplant rejection 32.68 9.45 35 319055 1301 70608053
Hepatic cirrhosis 32.57 9.45 55 319035 30676 70578678
Herpes simplex colitis 32.55 9.45 10 319080 22 70609332
Cutaneous mucormycosis 32.55 9.45 16 319074 164 70609190
Mean cell haemoglobin increased 32.50 9.45 58 319032 3515 70605839
Enthesopathy 32.50 9.45 5 319085 10864 70598490
Incorrect dose administered 32.41 9.45 172 318918 66547 70542807
Electrocardiogram QT prolonged 32.39 9.45 231 318859 83286 70526068
Hypocalcaemia 32.32 9.45 99 318991 44760 70564594
C-reactive protein increased 32.07 9.45 686 318404 109831 70499523
Cells in urine 32.04 9.45 17 319073 207 70609147
Kaposi's sarcoma 32.03 9.45 27 319063 739 70608615
Dystonia 32.01 9.45 25 319065 19681 70589673
Hypoalbuminaemia 31.83 9.45 170 318920 18952 70590402
Disseminated varicella zoster vaccine virus infection 31.79 9.45 14 319076 109 70609245
Cytomegalovirus gastrointestinal infection 31.60 9.45 22 319068 449 70608905
Oedema 31.33 9.45 306 318784 103275 70506079
Infective pulmonary exacerbation of cystic fibrosis 31.32 9.45 8 319082 12150 70597204
Urine leukocyte esterase 31.26 9.45 16 319074 180 70609174
Neuropathy peripheral 31.19 9.45 393 318697 126503 70482851
B-lymphocyte count decreased 31.13 9.45 33 319057 1212 70608142
Depression 31.12 9.45 670 318420 198304 70411050
Blood beta-D-glucan increased 31.09 9.45 23 319067 518 70608836
Toxic epidermal necrolysis 31.08 9.45 293 318797 39264 70570090
Graft loss 31.04 9.45 30 319060 985 70608369
Swollen tongue 31.00 9.45 76 319014 36970 70572384
Obliterative bronchiolitis 30.78 9.45 50 319040 2807 70606547
Enterococcus test positive 30.70 9.45 39 319051 1744 70607610
Metastases to liver 30.60 9.45 43 319047 25835 70583519
Breast cancer 30.35 9.45 66 319024 33483 70575871
Somnolence 30.34 9.45 738 318352 214868 70394486
Microscopic polyangiitis 30.24 9.45 20 319070 374 70608980
Autoimmune hepatitis 30.21 9.45 112 318978 10674 70598680
Unevaluable event 30.12 9.45 126 318964 51937 70557417
Heart rate irregular 30.05 9.45 233 318857 29510 70579844
Lung transplant rejection 30.03 9.45 34 319056 1346 70608008
Red blood cell count increased 29.85 9.45 59 319031 3865 70605489
Cryptococcal meningoencephalitis 29.79 9.45 17 319073 241 70609113
Intestinal perforation 29.75 9.45 147 318943 15897 70593457
Respiratory depression 29.62 9.45 41 319049 24790 70584564
Transplant dysfunction 29.61 9.45 83 319007 6826 70602528
Laryngeal stenosis 29.57 9.45 28 319062 896 70608458
Disseminated varicella zoster virus infection 29.53 9.45 21 319069 444 70608910
Palmar-plantar erythrodysaesthesia syndrome 29.49 9.45 57 319033 30190 70579164
Malacoplakia gastrointestinal 29.36 9.45 15 319075 168 70609186
Pneumoperitoneum 29.28 9.45 49 319041 2820 70606534
Urinary retention 29.22 9.45 129 318961 52391 70556963
Device dislocation 29.08 9.45 35 319055 22472 70586882
Intestine transplant rejection 29.07 9.45 12 319078 78 70609276
Central nervous system lesion 28.98 9.45 122 318968 12331 70597023
Perforation 28.95 9.45 32 319058 1233 70608121
Product dispensing error 28.90 9.45 9 319081 11999 70597355
Apoptosis 28.81 9.45 18 319072 304 70609050
Cytomegalovirus hepatitis 28.79 9.45 25 319065 713 70608641
Smear cervix abnormal 28.67 9.45 44 319046 2352 70607002
Adrenal insufficiency 28.66 9.45 203 318887 24992 70584362
Eosinophil percentage increased 28.66 9.45 34 319056 1416 70607938
Dyskinesia 28.64 9.45 92 318998 40982 70568372
Monocyte count decreased 28.51 9.45 50 319040 2989 70606365
Human polyomavirus infection 28.44 9.45 29 319061 1017 70608337
Mean cell haemoglobin decreased 28.44 9.45 69 319021 5199 70604155
Pneumocephalus 28.39 9.45 17 319073 265 70609089
Leukocytosis 28.32 9.45 288 318802 39380 70569974
Disorientation 28.32 9.45 149 318941 57774 70551580
Therapeutic response decreased 28.30 9.45 394 318696 58059 70551295
Venoocclusive disease 28.23 9.45 60 319030 4140 70605214
Partial seizures 28.03 9.45 91 318999 8114 70601240
Dyspnoea exertional 28.01 9.45 222 318868 78208 70531146
Inappropriate schedule of product administration 27.99 9.45 329 318761 107226 70502128
Oliguria 27.98 9.45 138 318952 14913 70594441
Bronchopleural fistula 27.74 9.45 23 319067 615 70608739
Bacillus infection 27.67 9.45 28 319062 973 70608381
Body temperature fluctuation 27.66 9.45 54 319036 3505 70605849
Atrioventricular block first degree 27.64 9.45 9 319081 11664 70597690
Product administration error 27.61 9.45 57 319033 29466 70579888
Calcium ionised decreased 27.55 9.45 22 319068 557 70608797
Thunderclap headache 27.49 9.45 16 319074 236 70609118
Disseminated strongyloidiasis 27.39 9.45 14 319076 157 70609197
Abnormal dreams 27.27 9.45 7 319083 10596 70598758
Encephalopathy 27.22 9.45 409 318681 61252 70548102
Arteriosclerosis coronary artery 27.07 9.45 20 319070 16195 70593159
Head injury 27.05 9.45 72 319018 34069 70575285
Listeria encephalitis 26.96 9.45 17 319073 292 70609062
Herpes simplex oesophagitis 26.83 9.45 18 319072 345 70609009
Breast cancer female 26.82 9.45 7 319083 10479 70598875
Haemoglobin urine 26.72 9.45 13 319077 130 70609224
Magnetic resonance imaging abnormal 26.65 9.45 50 319040 3150 70606204
Hepatic artery thrombosis 26.61 9.45 17 319073 299 70609055
Band neutrophil count increased 26.55 9.45 23 319067 654 70608700
Akathisia 26.54 9.45 11 319079 12282 70597072
Acute disseminated encephalomyelitis 26.51 9.45 17 319073 301 70609053
Oesophageal carcinoma 26.48 9.45 5 319085 9361 70599993
Lung neoplasm malignant 26.48 9.45 44 319046 24698 70584656
Aspergillosis oral 26.39 9.45 10 319080 50 70609304
Pneumatosis 26.37 9.45 25 319065 801 70608553
Device leakage 26.25 9.45 5 319085 9303 70600051
Blood potassium increased 26.20 9.45 52 319038 27274 70582080
Polychondritis 26.15 9.45 21 319069 536 70608818
Bronchospasm 26.14 9.45 184 318906 22608 70586746
Coronary artery dilatation 25.96 9.45 9 319081 33 70609321
Parvovirus infection 25.92 9.45 22 319068 608 70608746
Reticulocytosis 25.81 9.45 20 319070 484 70608870
Injection site urticaria 25.80 9.45 10 319080 11628 70597726
Antineutrophil cytoplasmic antibody positive 25.77 9.45 28 319062 1058 70608296
Blood immunoglobulin G decreased 25.68 9.45 47 319043 2905 70606449
Lip pruritus 25.66 9.45 24 319066 756 70608598
Thymus hypoplasia 25.65 9.45 22 319068 617 70608737
Obstructive airways disorder 25.64 9.45 49 319041 26064 70583290
Leukocyturia 25.38 9.45 34 319056 1603 70607751
Natural killer-cell leukaemia 25.29 9.45 12 319078 113 70609241
Monocytopenia 25.26 9.45 13 319077 148 70609206
Neoplasm progression 25.22 9.45 111 318979 45117 70564237
Adenoviral haemorrhagic cystitis 25.19 9.45 20 319070 502 70608852
Angiocentric lymphoma 25.15 9.45 26 319064 927 70608427
Femur fracture 25.14 9.45 81 319009 36051 70573303
Renal tubular injury 25.11 9.45 30 319060 1259 70608095
Polyomavirus viraemia 25.07 9.45 30 319060 1261 70608093
Colitis microscopic 25.05 9.45 5 319085 9000 70600354
Nodular regenerative hyperplasia 25.03 9.45 30 319060 1263 70608091
Leukoencephalopathy 25.01 9.45 81 319009 7213 70602141
Pancytopenia 24.98 9.45 872 318218 150235 70459119
Erectile dysfunction 24.97 9.45 15 319075 13547 70595807
Cataract 24.92 9.45 370 318720 55275 70554079
Central nervous system lymphoma 24.89 9.45 40 319050 2225 70607129
Hepatic infarction 24.89 9.45 25 319065 861 70608493
Myelitis 24.73 9.45 40 319050 2237 70607117
Oral pruritus 24.73 9.45 37 319053 1934 70607420
Sense of oppression 24.73 9.45 32 319058 1458 70607896
Type I hypersensitivity 24.72 9.45 53 319037 3679 70605675
Mean cell haemoglobin concentration increased 24.68 9.45 24 319066 794 70608560
Road traffic accident 24.66 9.45 77 319013 34605 70574749
Acute haemorrhagic leukoencephalitis 24.54 9.45 8 319082 23 70609331
Condition aggravated 24.36 9.45 2237 316853 425398 70183956
Pneumonia klebsiella 24.32 9.45 59 319031 4445 70604909
Pancreas transplant rejection 24.25 9.45 16 319074 298 70609056
Granuloma skin 24.23 9.45 3 319087 7679 70601675
Withdrawal syndrome 24.22 9.45 47 319043 24857 70584497
Rhinovirus infection 24.21 9.45 76 319014 6657 70602697
Aphthous ulcer 24.20 9.45 130 318960 14526 70594828
Throat tightness 24.17 9.45 194 318896 24828 70584526
Weight increased 24.13 9.45 1327 317763 241004 70368350
Blood lactate dehydrogenase increased 24.11 9.45 253 318837 34874 70574480
Meningitis cryptococcal 24.07 9.45 49 319041 3279 70606075
CSF protein increased 24.03 9.45 28 319062 1144 70608210
Hospice care 24.03 9.45 4 319086 8201 70601153
Neutropenic sepsis 24.02 9.45 47 319043 24783 70584571
Immunosuppression 24.01 9.45 109 318981 11383 70597971
Presyncope 23.97 9.45 87 319003 37351 70572003
Schizophrenia 23.95 9.45 24 319066 16744 70592610
Cardiac arrest 23.90 9.45 542 318548 159292 70450062
pH urine increased 23.86 9.45 18 319072 418 70608936
Cerebral artery stenosis 23.86 9.45 22 319068 680 70608674
Subdural haematoma 23.82 9.45 61 319029 29237 70580117
Graft complication 23.81 9.45 22 319068 682 70608672
Breast cancer metastatic 23.72 9.45 8 319082 10138 70599216
Urinary tract candidiasis 23.68 9.45 22 319068 687 70608667
Limbic encephalitis 23.60 9.45 23 319067 763 70608591
Colitis ulcerative 23.60 9.45 245 318845 33678 70575676
Thrombosis 23.55 9.45 221 318869 75184 70534170
Atypical mycobacterial pneumonia 23.44 9.45 12 319078 135 70609219
Eosinophil percentage decreased 23.42 9.45 15 319075 265 70609089
Central nervous system vasculitis 23.41 9.45 29 319061 1264 70608090
Staphylococcal mediastinitis 23.13 9.45 9 319081 49 70609305
Blood parathyroid hormone decreased 23.13 9.45 6 319084 9018 70600336
Tendonitis 23.07 9.45 40 319050 22082 70587272
Organising pneumonia 23.03 9.45 98 318992 9952 70599402
Anorectal ulcer 22.98 9.45 9 319081 50 70609304
Non-consummation 22.98 9.45 9 319081 50 70609304
Lymphoid tissue hypoplasia 22.87 9.45 20 319070 576 70608778
Lymphoproliferative disorder 22.82 9.45 64 319026 5265 70604089
Dementia 22.81 9.45 41 319049 22324 70587030
Swollen joint count increased 22.74 9.45 17 319073 13683 70595671
Parainfluenzae virus infection 22.73 9.45 62 319028 5018 70604336
Fungal skin infection 22.73 9.45 65 319025 5407 70603947
Immunoglobulins decreased 22.73 9.45 30 319060 1394 70607960
Biloma 22.70 9.45 12 319078 145 70609209
Enteritis 22.69 9.45 116 318974 12715 70596639
Serratia infection 22.66 9.45 32 319058 1586 70607768
Urine bilirubin decreased 22.63 9.45 12 319078 146 70609208
Blood albumin increased 22.63 9.45 30 319060 1400 70607954
Blood loss anaemia 22.61 9.45 19 319071 14422 70594932
Transfusion 22.57 9.45 31 319059 18805 70590549
Autoimmune thyroiditis 22.56 9.45 52 319038 3790 70605564
Drug tolerance decreased 22.56 9.45 8 319082 9825 70599529
Arteriovenous fistula 22.52 9.45 28 319062 1225 70608129
Hepatitis B 22.51 9.45 84 319006 8030 70601324
Hypokalaemia 22.51 9.45 435 318655 130753 70478601
Viral infection 22.48 9.45 268 318822 38123 70571231
Bacterial vulvovaginitis 22.45 9.45 19 319071 523 70608831
Factor XIII deficiency 22.37 9.45 10 319080 81 70609273
Scopulariopsis infection 22.36 9.45 11 319079 113 70609241
Sideroblastic anaemia 22.32 9.45 14 319076 238 70609116
Temperature intolerance 22.31 9.45 88 319002 8635 70600719
Meningoencephalitis viral 22.27 9.45 17 319073 402 70608952
Anaphylactic reaction 22.27 9.45 467 318623 74507 70534847
Hepatocellular carcinoma 22.26 9.45 9 319081 10199 70599155
Haemolysis 22.25 9.45 107 318983 11444 70597910
Lymphocele 22.20 9.45 32 319058 1617 70607737
Poikiloderma 22.07 9.45 16 319074 349 70609005
Eschar 22.02 9.45 27 319063 1164 70608190
Blood creatinine decreased 22.02 9.45 78 319012 7271 70602083
Hepatic cancer 22.01 9.45 8 319082 9675 70599679
Endocrine ophthalmopathy 21.94 9.45 19 319071 540 70608814
Product complaint 21.87 9.45 14 319076 12217 70597137
Parkinsonism 21.82 9.45 22 319068 15303 70594051
Tri-iodothyronine free increased 21.78 9.45 14 319076 249 70609105
Peripheral vascular disorder 21.74 9.45 4 319086 7628 70601726
Cystitis bacterial 21.62 9.45 18 319072 484 70608870
Rubella antibody positive 21.61 9.45 9 319081 60 70609294
Periumbilical abscess 21.61 9.45 9 319081 60 70609294
Body temperature increased 21.56 9.45 274 318816 39560 70569794
Wheezing 21.55 9.45 296 318794 93874 70515480
White blood cell count increased 21.53 9.45 436 318654 69137 70540217
Viral cardiomyopathy 21.45 9.45 8 319082 38 70609316
Hepatic function abnormal 21.34 9.45 427 318663 67569 70541785
Myoclonus 21.32 9.45 55 319035 26300 70583054
Klebsiella test positive 21.28 9.45 29 319061 1390 70607964
Pyelonephritis 21.18 9.45 148 318942 18141 70591213
Cestode infection 21.07 9.45 14 319076 264 70609090
Microsporidia infection 21.04 9.45 23 319067 875 70608479
Oral pain 21.04 9.45 64 319026 29002 70580352
Engraft failure 21.02 9.45 20 319070 644 70608710
Birdshot chorioretinopathy 21.00 9.45 10 319080 95 70609259
Mental status changes 20.99 9.45 182 318908 62919 70546435
Lipaemic index score 20.95 9.45 11 319079 131 70609223
Herpes simplex viraemia 20.93 9.45 14 319076 267 70609087
Neuropsychiatric lupus 20.92 9.45 12 319078 172 70609182
Meningitis fungal 20.92 9.45 12 319078 172 70609182
Epistaxis 20.90 9.45 330 318760 102297 70507057
Sensitivity to weather change 20.84 9.45 4 319086 7401 70601953
Serum ferritin increased 20.78 9.45 88 319002 8917 70600437
Orbital apex syndrome 20.78 9.45 9 319081 67 70609287
Lip dry 20.74 9.45 9 319081 9776 70599578
Drug level below therapeutic 20.72 9.45 86 319004 8637 70600717
Urinary tract infection bacterial 20.69 9.45 63 319027 5428 70603926
Alveolitis 20.66 9.45 50 319040 3761 70605593
Infusion site extravasation 20.66 9.45 81 319009 7927 70601427
Renal graft infection 20.65 9.45 17 319073 450 70608904
Thrombotic thrombocytopenic purpura 20.64 9.45 68 319022 6109 70603245
Tachycardia 20.56 9.45 891 318199 157655 70451699
Menstruation irregular 20.54 9.45 56 319034 4532 70604822
Retinal detachment 20.53 9.45 84 319006 8383 70600971
Blindness cortical 20.53 9.45 23 319067 900 70608454
Pyelonephritis acute 20.51 9.45 63 319027 5454 70603900
Porphyria acute 20.50 9.45 27 319063 1252 70608102
Night sweats 20.45 9.45 114 318976 43570 70565784
Malacoplakia vesicae 20.44 9.45 9 319081 70 70609284
Morganella infection 20.41 9.45 25 319065 1077 70608277
Cytokine storm 20.36 9.45 23 319067 908 70608446
Chronic kidney disease 20.35 9.45 176 318914 60881 70548473
CSF oligoclonal band present 20.31 9.45 14 319076 281 70609073
Urine oxalate increased 20.28 9.45 13 319077 230 70609124
Salivary hypersecretion 20.24 9.45 17 319073 12908 70596446
Blood brain barrier defect 20.24 9.45 11 319079 141 70609213
Angina unstable 20.23 9.45 25 319065 15868 70593486
Osmotic demyelination syndrome 20.20 9.45 27 319063 1270 70608084
Drug level decreased 20.18 9.45 111 318979 12513 70596841
Premenstrual syndrome 20.17 9.45 18 319072 533 70608821
Staphylococcal bacteraemia 20.17 9.45 101 318989 10981 70598373
Lichen sclerosus 20.16 9.45 23 319067 918 70608436
Viral sepsis 20.11 9.45 11 319079 143 70609211
Exophthalmos 20.11 9.45 30 319060 1564 70607790
Anti-thyroid antibody positive 20.05 9.45 17 319073 469 70608885
Visceral leishmaniasis 20.01 9.45 24 319066 1011 70608343
Pseudomonal bacteraemia 19.96 9.45 39 319051 2533 70606821
Flatulence 19.92 9.45 96 318994 38085 70571269
Hepatic failure 19.83 9.45 367 318723 57258 70552096
Splenic embolism 19.77 9.45 12 319078 192 70609162
Bradyphrenia 19.76 9.45 10 319080 9936 70599418
Blindness 19.74 9.45 175 318915 23052 70586302
Norovirus test positive 19.72 9.45 17 319073 480 70608874
Red cell distribution width decreased 19.61 9.45 30 319060 1599 70607755
Red blood cell schistocytes present 19.53 9.45 18 319072 556 70608798
Respiratory tract infection fungal 19.51 9.45 25 319065 1128 70608226
Colitis 19.45 9.45 399 318691 63415 70545939
Agitation 19.44 9.45 299 318791 93076 70516278
Sudden death 19.42 9.45 41 319049 21023 70588331
Capillary leak syndrome 19.39 9.45 46 319044 3416 70605938
Histoplasmosis disseminated 19.37 9.45 34 319056 2034 70607320
Abscess 19.34 9.45 159 318931 20495 70588859
Meningitis bacterial 19.32 9.45 38 319052 2480 70606874
Neurosarcoidosis 19.29 9.45 15 319075 365 70608989
Electrocardiogram QRS complex prolonged 19.28 9.45 10 319080 9796 70599558
Joint tuberculosis 19.27 9.45 11 319079 156 70609198
Vesicoureteric reflux 19.27 9.45 10 319080 116 70609238
Pulmonary tuberculosis 19.15 9.45 78 319012 7767 70601587
Cytomegalovirus gastritis 19.07 9.45 16 319074 435 70608919
Hypoacusis 19.06 9.45 61 319029 27208 70582146
Hepatic enzyme increased 19.01 9.45 549 318541 156441 70452913
Joint injury 19 9.45 60 319030 26872 70582482
Atypical mycobacterial infection 18.88 9.45 28 319062 1452 70607902
Cholelithiasis 18.81 9.45 130 318960 47210 70562144
Nephrolithiasis 18.78 9.45 130 318960 47193 70562161
Gastrointestinal mucormycosis 18.77 9.45 15 319075 380 70608974
CSF measles antibody positive 18.77 9.45 8 319082 57 70609297
Ultrasound ovary abnormal 18.76 9.45 9 319081 87 70609267
Cystitis viral 18.76 9.45 19 319071 661 70608693
Antinuclear antibody 18.70 9.45 16 319074 447 70608907
Rhesus antigen positive 18.69 9.45 10 319080 124 70609230
Wound evisceration 18.69 9.45 10 319080 124 70609230
Pharyngeal dyskinesia 18.65 9.45 8 319082 58 70609296
Metastases to bone 18.64 9.45 46 319044 22330 70587024
Haemorrhagic varicella syndrome 18.60 9.45 5 319085 5 70609349
Depressed mood 18.59 9.45 118 318972 43702 70565652
Shock 18.57 9.45 270 318820 40155 70569199
Blood sodium decreased 18.57 9.45 74 319016 30924 70578430
Capillaritis 18.56 9.45 13 319077 268 70609086
Eye infection toxoplasmal 18.51 9.45 17 319073 523 70608831
Angiosarcoma 18.51 9.45 17 319073 523 70608831
White blood cells urine 18.48 9.45 15 319075 389 70608965
Aspergilloma 18.42 9.45 17 319073 526 70608828
Biliary anastomosis complication 18.34 9.45 11 319079 172 70609182
Second primary malignancy 18.28 9.45 19 319071 13032 70596322
Ageusia 18.27 9.45 24 319066 14838 70594516
Epstein-Barr virus test positive 18.25 9.45 23 319067 1020 70608334
Peliosis hepatis 18.25 9.45 9 319081 93 70609261
Vitritis infective 18.21 9.45 6 319084 18 70609336
Peritoneal candidiasis 18.21 9.45 6 319084 18 70609336
Bacterial pyelonephritis 18.21 9.45 17 319073 534 70608820
Kidney rupture 18.21 9.45 12 319078 223 70609131
Deep vein thrombosis 18.20 9.45 371 318719 110671 70498683
Brain oedema 18.17 9.45 173 318917 23245 70586109
Q fever 18.16 9.45 12 319078 224 70609130
Torulopsis infection 18.16 9.45 7 319083 37 70609317
Bone erosion 18.15 9.45 25 319065 15148 70594206
Hepatitis cholestatic 18.11 9.45 108 318982 12542 70596812
Mean cell volume decreased 18.09 9.45 52 319038 4338 70605016
Tuberculosis gastrointestinal 18.08 9.45 17 319073 539 70608815
Therapeutic product effect incomplete 18.06 9.45 406 318684 119476 70489878
Creatinine renal clearance decreased 18.03 9.45 31 319059 17169 70592185
Basal cell carcinoma 18.01 9.45 84 319006 33614 70575740
Perineal ulceration 17.98 9.45 8 319082 64 70609290
Nocturia 17.98 9.45 17 319073 12187 70597167
Herpes zoster meningoencephalitis 17.96 9.45 19 319071 696 70608658
Thrombocytopenic purpura 17.96 9.45 35 319055 2269 70607085
Coma scale abnormal 17.95 9.45 7 319083 8109 70601245
Herpes simplex hepatitis 17.95 9.45 16 319074 473 70608881
Intestinal obstruction 17.81 9.45 102 318988 38723 70570631
Fibromyalgia 17.80 9.45 134 318956 47740 70561614
Diabetic ketoacidosis 17.77 9.45 77 319013 31435 70577919
Aplasia pure red cell 17.75 9.45 73 319017 7301 70602053
Cerebral fungal infection 17.75 9.45 14 319076 348 70609006
Osteoporosis 17.72 9.45 314 318776 48593 70560761
Renal artery stenosis 17.71 9.45 43 319047 3241 70606113
Back disorder 17.68 9.45 13 319077 10551 70598803
Creatinine urine decreased 17.67 9.45 12 319078 235 70609119
Tremor 17.66 9.45 549 318541 155075 70454279
B-lymphocyte count increased 17.57 9.45 10 319080 141 70609213
Paraplegia 17.57 9.45 54 319036 4676 70604678
Bifidobacterium infection 17.52 9.45 6 319084 21 70609333
Glomerulonephritis membranous 17.51 9.45 28 319062 1551 70607803
Blood thyroid stimulating hormone increased 17.40 9.45 80 319010 8399 70600955
Tri-iodothyronine free decreased 17.38 9.45 14 319076 359 70608995
Myelocyte percentage increased 17.36 9.45 12 319078 242 70609112
Delayed engraftment 17.28 9.45 12 319078 244 70609110
Melaena 17.24 9.45 166 318924 56189 70553165
Antiphospholipid syndrome 17.24 9.45 29 319061 1676 70607678
Injury 17.20 9.45 199 318891 65046 70544308
Hyperoxaluria 17.19 9.45 13 319077 303 70609051
Bundle branch block left 17.14 9.45 13 319077 10386 70598968
Bordetella infection 17.08 9.45 9 319081 108 70609246
Injection site induration 17.08 9.45 10 319080 9158 70600196
Hyperthermia 17.07 9.45 131 318959 16540 70592814
Monocyte percentage decreased 17.07 9.45 12 319078 249 70609105
Post-traumatic stress disorder 17.01 9.45 51 319039 4356 70604998
Escherichia urinary tract infection 17.01 9.45 106 318984 12501 70596853
Scleritis 17.01 9.45 45 319045 3577 70605777
Hairy cell leukaemia 16.98 9.45 8 319082 74 70609280
Hypoproteinaemia 16.98 9.45 45 319045 3581 70605773
Oropharyngeal pain 16.98 9.45 560 318530 95750 70513604
Uterine perforation 16.97 9.45 3 319087 5888 70603466
Dysmenorrhoea 16.92 9.45 37 319053 2603 70606751
Fungal test positive 16.92 9.45 22 319068 1007 70608347
Accelerated idioventricular rhythm 16.92 9.45 10 319080 152 70609202
Bronchopneumopathy 16.87 9.45 18 319072 666 70608688
Injection site extravasation 16.84 9.45 81 319009 8665 70600689
Rash 16.76 9.45 2026 317064 508536 70100818
Disseminated blastomycosis 16.72 9.45 9 319081 113 70609241
Amoebiasis 16.72 9.45 9 319081 113 70609241
Intestinal ulcer 16.69 9.45 29 319061 1721 70607633
Complications of transplanted liver 16.61 9.45 14 319076 383 70608971
Post procedural bile leak 16.61 9.45 14 319076 383 70608971
Renal necrosis 16.58 9.45 12 319078 261 70609093
Enterococcal sepsis 16.58 9.45 36 319054 2521 70606833
Muir-Torre syndrome 16.52 9.45 7 319083 49 70609305
Tuberculosis 16.52 9.45 119 318971 14729 70594625
Herpes simplex encephalitis 16.51 9.45 18 319072 683 70608671
IVth nerve paralysis 16.47 9.45 10 319080 160 70609194
Diastolic hypotension 16.31 9.45 10 319080 163 70609191
Klebsiella sepsis 16.28 9.45 38 319052 2793 70606561
Cytomegalovirus duodenitis 16.27 9.45 8 319082 82 70609272
Acne 16.23 9.45 178 318912 24811 70584543
Amnesia 16.22 9.45 153 318937 52002 70557352
Eosinophilic granulomatosis with polyangiitis 16.20 9.45 41 319049 3172 70606182
Proteus infection 16.17 9.45 28 319062 1657 70607697
Encephalitis fungal 16.15 9.45 10 319080 166 70609188
Hypofibrinogenaemia 16.14 9.45 30 319060 1877 70607477
Colorectal cancer 16.12 9.45 9 319081 8461 70600893
Intravascular haemolysis 16.11 9.45 18 319072 702 70608652
Hot flush 16.10 9.45 313 318777 49271 70560083
Pericarditis fungal 16.10 9.45 10 319080 167 70609187
Vaginal haemorrhage 16.06 9.45 43 319047 20309 70589045
Faeces discoloured 16.06 9.45 64 319026 26745 70582609
Hepatic artery occlusion 16.03 9.45 8 319082 85 70609269
Hepatic cytolysis 16.00 9.45 144 318946 19048 70590306
Obesity 15.98 9.45 64 319026 26707 70582647
Respiratory disorder 15.93 9.45 256 318834 38867 70570487
Central obesity 15.86 9.45 27 319063 1576 70607778
Acute respiratory failure 15.85 9.45 334 318756 53331 70556023
Gastroduodenal ulcer 15.81 9.45 15 319075 481 70608873
Diaphragmatic injury 15.81 9.45 9 319081 127 70609227
Facet joint syndrome 15.79 9.45 4 319086 6109 70603245
Hypertensive encephalopathy 15.78 9.45 20 319070 892 70608462
Wolff-Parkinson-White syndrome 15.75 9.45 12 319078 283 70609071
Breast cancer stage I 15.75 9.45 4 319086 6098 70603256
Adrenal atrophy 15.73 9.45 7 319083 56 70609298
Gonococcal infection 15.73 9.45 7 319083 56 70609298
Scedosporium infection 15.71 9.45 25 319065 1379 70607975
Blood creatine phosphokinase increased 15.70 9.45 188 318902 61075 70548279
Trichodysplasia spinulosa 15.69 9.45 18 319072 723 70608631
Tumour lysis syndrome 15.69 9.45 156 318934 21204 70588150
Pyomyositis 15.65 9.45 16 319074 563 70608791
Cutaneous nocardiosis 15.65 9.45 10 319080 176 70609178
Haemoperitoneum 15.61 9.45 47 319043 4024 70605330
Cerebellar stroke 15.56 9.45 15 319075 491 70608863
Tachypnoea 15.50 9.45 197 318893 28441 70580913
Passenger lymphocyte syndrome 15.48 9.45 8 319082 92 70609262
Bone marrow failure 15.45 9.45 308 318782 48702 70560652
Coombs positive haemolytic anaemia 15.42 9.45 20 319070 913 70608441
Haemorrhoids 15.38 9.45 61 319029 25527 70583827
Atrial flutter 15.26 9.45 44 319046 20283 70589071
Gastropleural fistula 15.22 9.45 7 319083 61 70609293
Haematocrit decreased 15.21 9.45 351 318739 56907 70552447
Immune-mediated lung disease 15.21 9.45 27 319063 1630 70607724
Venoocclusive liver disease 15.18 9.45 91 318999 10587 70598767
Hepatic necrosis 15.17 9.45 78 319012 8568 70600786
Liver function test abnormal 15.16 9.45 189 318901 60957 70548397
Multi-organ disorder 15.15 9.45 33 319057 2316 70607038
Listeria sepsis 15.13 9.45 17 319073 667 70608687
Chronic graft versus host disease in liver 15.13 9.45 16 319074 586 70608768
Multiple allergies 15.13 9.45 8 319082 7752 70601602
Abdominal compartment syndrome 15.12 9.45 25 319065 1424 70607930
Fracture 15.10 9.45 43 319047 19901 70589453
Atrioventricular block 15.08 9.45 21 319069 12667 70596687
Mycobacterial infection 15.04 9.45 42 319048 3446 70605908
Musculoskeletal pain 15.04 9.45 301 318789 90026 70519328
Splenic necrosis 15.04 9.45 8 319082 98 70609256
Meningitis aseptic 15.02 9.45 63 319027 6356 70602998
Anxiety 15.02 9.45 824 318266 219506 70389848
Papilloma viral infection 15.01 9.45 26 319064 1539 70607815
Chorioretinitis 14.99 9.45 20 319070 939 70608415
Aspiration 14.99 9.45 36 319054 17639 70591715
Glucose urine present 14.97 9.45 27 319063 1650 70607704
Interleukin level increased 14.94 9.45 14 319076 442 70608912
Cyanosis 14.93 9.45 165 318925 23041 70586313
Thyrotoxic periodic paralysis 14.90 9.45 8 319082 100 70609254
Erythema infectiosum 14.89 9.45 10 319080 192 70609162
Meningitis exserohilum 14.88 9.45 4 319086 4 70609350
Muscle abscess 14.88 9.45 20 319070 946 70608408
Marrow hyperplasia 14.87 9.45 25 319065 1444 70607910
Pulmonary embolism 14.87 9.45 562 318528 155305 70454049
Electrocardiogram abnormal 14.85 9.45 27 319063 14637 70594717
Infusion site pain 14.84 9.45 96 318994 11468 70597886
Paranoia 14.83 9.45 35 319055 17253 70592101
Cholecystectomy 14.82 9.45 10 319080 8487 70600867
Arterial rupture 14.81 9.45 18 319072 769 70608585
Lip swelling 14.81 9.45 91 318999 33963 70575391
Polyglandular disorder 14.80 9.45 6 319084 37 70609317
Herpes simplex reactivation 14.79 9.45 13 319077 377 70608977
Quadriparesis 14.79 9.45 39 319051 3094 70606260
Post procedural urine leak 14.77 9.45 9 319081 145 70609209
Sputum discoloured 14.75 9.45 40 319050 18811 70590543
Thyroid stimulating immunoglobulin 14.74 9.45 7 319083 66 70609288
Herpes simplex meningoencephalitis 14.74 9.45 7 319083 66 70609288
Fungal endocarditis 14.74 9.45 15 319075 525 70608829
Syringe issue 14.74 9.45 3 319087 5325 70604029
Multiple fractures 14.69 9.45 6 319084 6759 70602595
Cytomegalovirus nephritis 14.66 9.45 9 319081 147 70609207
Cold type haemolytic anaemia 14.66 9.45 12 319078 315 70609039
Wound infection bacterial 14.63 9.45 18 319072 779 70608575
Pneumonia necrotising 14.60 9.45 20 319070 963 70608391
Oral discomfort 14.60 9.45 11 319079 8820 70600534
Seizure 14.57 9.45 653 318437 177309 70432045
Gastrointestinal candidiasis 14.56 9.45 13 319077 385 70608969
Encephalomyelitis 14.54 9.45 10 319080 200 70609154
Anti-neutrophil cytoplasmic antibody positive vasculitis 14.52 9.45 40 319050 3257 70606097
Catheterisation cardiac 14.48 9.45 3 319087 5260 70604094
Central nervous system lupus 14.45 9.45 13 319077 389 70608965
Dizziness postural 14.32 9.45 15 319075 10253 70599101
Pleural mass 14.30 9.45 7 319083 71 70609283
Lactic acidosis 14.30 9.45 206 318884 64818 70544536
Injection site discolouration 14.29 9.45 7 319083 7085 70602269
Transient hypogammaglobulinaemia of infancy 14.29 9.45 6 319084 41 70609313
Radiotherapy to brain 14.29 9.45 6 319084 41 70609313
Muscle rigidity 14.27 9.45 40 319050 18610 70590744
Beta 2 microglobulin increased 14.25 9.45 12 319078 328 70609026
Diarrhoea haemorrhagic 14.22 9.45 96 318994 11634 70597720
Microangiopathic haemolytic anaemia 14.21 9.45 24 319066 1392 70607962
Haematopoietic stem cell mobilisation 14.20 9.45 10 319080 208 70609146
Heliotrope rash 14.20 9.45 9 319081 156 70609198
Aspergillus test positive 14.16 9.45 17 319073 717 70608637
Vessel puncture site bruise 14.16 9.45 14 319076 473 70608881
Renal vein thrombosis 14.13 9.45 14 319076 474 70608880
Disseminated aspergillosis 14.13 9.45 18 319072 807 70608547
Femoral neck fracture 14.13 9.45 12 319078 9061 70600293
Skin fissures 14.12 9.45 93 318997 11177 70598177
Graft infection 14.12 9.45 16 319074 634 70608720
Autoimmune colitis 14.08 9.45 25 319065 1509 70607845
Encephalitis brain stem 14.08 9.45 10 319080 211 70609143
Emphysematous pyelonephritis 14.06 9.45 11 319079 270 70609084
Meningitis chemical 14.04 9.45 10 319080 212 70609142
Sinusitis 14.02 9.45 620 318470 168575 70440779
Paraparesis 14.01 9.45 42 319048 3587 70605767
Exostosis 14.01 9.45 27 319063 14318 70595036
Myelocyte present 14.00 9.45 4 319086 6 70609348
Vein collapse 13.98 9.45 19 319071 908 70608446
Product use issue 13.97 9.45 664 318426 179273 70430081
Enterococcal bacteraemia 13.97 9.45 35 319055 2691 70606663
Pneumonia lipoid 13.95 9.45 9 319081 161 70609193
Bladder cancer 13.94 9.45 36 319054 17206 70592148
Magnesium deficiency 13.91 9.45 15 319075 562 70608792
Familial periodic paralysis 13.91 9.45 9 319081 162 70609192
Alcohol abuse 13.87 9.45 3 319087 5104 70604250
Prophylaxis against transplant rejection 13.86 9.45 8 319082 116 70609238
Hemianopia 13.85 9.45 26 319064 1639 70607715
Parathyroid hyperplasia 13.81 9.45 9 319081 164 70609190
Body height decreased 13.79 9.45 9 319081 7774 70601580
Therapeutic response shortened 13.77 9.45 102 318988 12736 70596618
Red blood cell elliptocytes present 13.76 9.45 9 319081 165 70609189
Nephrogenic systemic fibrosis 13.75 9.45 5 319085 6047 70603307
Double stranded DNA antibody positive 13.75 9.45 13 319077 415 70608939
Haemoglobinuria 13.74 9.45 17 319073 740 70608614
Irritability 13.73 9.45 108 318982 38117 70571237
Glomerulonephritis membranoproliferative 13.72 9.45 15 319075 571 70608783
Nephropathy 13.71 9.45 77 319013 8748 70600606
Blood 1,25-dihydroxycholecalciferol increased 13.71 9.45 5 319085 22 70609332
Septic pulmonary embolism 13.70 9.45 6 319084 46 70609308
Chimerism 13.69 9.45 11 319079 281 70609073
Hip fracture 13.65 9.45 73 319017 28190 70581164
Acinetobacter test positive 13.64 9.45 10 319080 222 70609132
Skin cancer 13.64 9.45 25 319065 13511 70595843
Leishmaniasis 13.62 9.45 12 319078 349 70609005
Polymenorrhoea 13.62 9.45 19 319071 931 70608423
Mucosal ulceration 13.60 9.45 27 319063 1774 70607580
Sensory loss 13.57 9.45 93 318997 11326 70598028
Internal haemorrhage 13.56 9.45 10 319080 8106 70601248
Hypoxia 13.56 9.45 531 318559 92813 70516541
Uraemic encephalopathy 13.55 9.45 15 319075 579 70608775
Neurological symptom 13.52 9.45 68 319022 7405 70601949
Arthritis fungal 13.51 9.45 8 319082 122 70609232
Embolic stroke 13.51 9.45 8 319082 7281 70602073
Ovarian fibroma 13.50 9.45 7 319083 81 70609273
Dry throat 13.45 9.45 63 319027 6665 70602689
Expired product administered 13.43 9.45 6 319084 6407 70602947
Cutaneous malacoplakia 13.43 9.45 7 319083 82 70609272
Acute myeloid leukaemia recurrent 13.40 9.45 37 319053 3017 70606337
Hepatic steatosis 13.36 9.45 93 318997 33720 70575634
Transaminases increased 13.36 9.45 291 318799 46727 70562627
Gynaecomastia 13.35 9.45 7 319083 6816 70602538
Complication associated with device 13.33 9.45 32 319058 15681 70593673
Allergy to plants 13.32 9.45 15 319075 590 70608764
Tubulointerstitial nephritis 13.31 9.45 216 318874 32860 70576494
Allergy test positive 13.30 9.45 13 319077 433 70608921
Jaundice cholestatic 13.29 9.45 13 319077 9171 70600183
Middle insomnia 13.25 9.45 27 319063 14026 70595328
Ophthalmoplegia 13.25 9.45 35 319055 2780 70606574
H3N2 influenza 13.23 9.45 3 319087 0 70609354
Malignant catatonia 13.20 9.45 13 319077 437 70608917
Diverticulum 13.18 9.45 26 319064 13667 70595687
Coronary arterial stent insertion 13.15 9.45 5 319085 5882 70603472
Disability 13.12 9.45 30 319060 14953 70594401
Spinal stenosis 13.11 9.45 29 319061 14624 70594730
Red blood cell sedimentation rate 13.10 9.45 3 319087 4907 70604447
Sinus node dysfunction 13.10 9.45 8 319082 7161 70602193
Brain herniation 13.09 9.45 64 319026 6892 70602462
Renal haemorrhage 13.03 9.45 29 319061 2065 70607289
Anastomotic haemorrhage 13.01 9.45 10 319080 239 70609115
Immune-mediated myocarditis 13.01 9.45 16 319074 692 70608662
Arterial occlusive disease 13.00 9.45 69 319021 7673 70601681
Thyroid stimulating immunoglobulin increased 13.00 9.45 7 319083 88 70609266
Lupus myocarditis 13.00 9.45 7 319083 88 70609266
Haemostasis 12.96 9.45 11 319079 304 70609050
Reticulocytopenia 12.96 9.45 9 319081 183 70609171
Macular degeneration 12.94 9.45 9 319081 7519 70601835
Infected varicose vein 12.88 9.45 5 319085 27 70609327
Arteritis coronary 12.88 9.45 6 319084 54 70609300
Rash maculo-papular 12.86 9.45 308 318782 50237 70559117
Campylobacter gastroenteritis 12.84 9.45 21 319069 1186 70608168
Intra-abdominal haemorrhage 12.83 9.45 45 319045 4173 70605181
Allergy to chemicals 12.82 9.45 28 319062 1968 70607386
Oral candidiasis 12.82 9.45 170 318920 24782 70584572
Stridor 12.82 9.45 51 319039 5025 70604329
Dysarthria 12.81 9.45 200 318890 62113 70547241
Porokeratosis 12.80 9.45 10 319080 245 70609109
Blastomycosis 12.78 9.45 14 319076 534 70608820
Varicella 12.77 9.45 34 319056 2713 70606641
Hepatosplenomegaly 12.77 9.45 55 319035 5615 70603739
Butterfly rash 12.74 9.45 23 319067 1407 70607947
Faecaloma 12.72 9.45 17 319073 10434 70598920
Paraesthesia ear 12.71 9.45 9 319081 189 70609165
Drug dependence 12.70 9.45 107 318983 37214 70572140
Coccidioidomycosis 12.69 9.45 21 319069 1197 70608157
Abdominal distension 12.68 9.45 366 318724 104303 70505051
Eye luxation 12.67 9.45 4 319086 10 70609344
Large intestine polyp 12.66 9.45 20 319070 11456 70597898
Geotrichum infection 12.66 9.45 19 319071 996 70608358
Diabetic macroangiopathy 12.61 9.45 8 319082 139 70609215
Renal cancer 12.60 9.45 21 319069 11775 70597579
Status asthmaticus 12.57 9.45 19 319071 1002 70608352
CD8 lymphocytes decreased 12.56 9.45 10 319080 252 70609102
Meningoencephalitis bacterial 12.55 9.45 9 319081 193 70609161
Application site erythema 12.52 9.45 3 319087 4758 70604596
Granulomatous liver disease 12.52 9.45 21 319069 1211 70608143
International normalised ratio abnormal 12.51 9.45 4 319086 5243 70604111
Hypercapnia 12.50 9.45 72 319018 8257 70601097
Abnormal loss of weight 12.49 9.45 10 319080 7774 70601580
Abscess fungal 12.46 9.45 10 319080 255 70609099
Amoebic dysentery 12.45 9.45 5 319085 30 70609324
Hallucination, visual 12.44 9.45 79 319011 29258 70580096
Microangiopathy 12.43 9.45 25 319065 1658 70607696
Urine bilirubin increased 12.41 9.45 8 319082 143 70609211
Inadequate aseptic technique in use of product 12.41 9.45 7 319083 97 70609257
Anaphylactoid reaction 12.40 9.45 50 319040 4957 70604397
Atypical haemolytic uraemic syndrome 12.38 9.45 17 319073 821 70608533
Enterocolitis bacterial 12.37 9.45 14 319076 554 70608800
Growth retardation 12.34 9.45 25 319065 1667 70607687
Meningomyelitis herpes 12.33 9.45 6 319084 60 70609294
Viral test positive 12.32 9.45 12 319078 398 70608956
Tularaemia 12.28 9.45 7 319083 99 70609255
Thrombosis in device 12.24 9.45 4 319086 5171 70604183
Fungal sepsis 12.23 9.45 25 319065 1678 70607676
Dyspepsia 12.22 9.45 306 318784 88771 70520583
Hysterectomy 12.15 9.45 5 319085 5607 70603747
Breast abscess 12.15 9.45 21 319069 1241 70608113
Encephalitis viral 12.15 9.45 31 319059 2411 70606943
Creatinine urine increased 12.14 9.45 13 319077 483 70608871
Oral fungal infection 12.14 9.45 37 319053 3189 70606165
Myelitis transverse 12.12 9.45 25 319065 1689 70607665
Necrosis 12.12 9.45 73 319017 8508 70600846
Hypomagnesaemia 12.08 9.45 121 318969 40643 70568711
Hepatic vein stenosis 12.08 9.45 6 319084 63 70609291
Pulmonary necrosis 12.08 9.45 13 319077 486 70608868
Hypocomplementaemia 12.04 9.45 9 319081 206 70609148
Clumsiness 12.04 9.45 34 319056 2808 70606546
Dry skin 12.02 9.45 178 318912 55753 70553601
Gait inability 12.00 9.45 145 318945 47030 70562324
Myelocyte count increased 12.00 9.45 16 319074 751 70608603
Hepatitis A 11.99 9.45 17 319073 846 70608508
Respiratory gas exchange disorder 11.98 9.45 16 319074 752 70608602
Expanded disability status scale score increased 11.97 9.45 14 319076 574 70608780
Delusion 11.96 9.45 45 319045 19120 70590234
Diffuse mesangial sclerosis 11.92 9.45 6 319084 65 70609289
Inflammatory marker increased 11.91 9.45 77 319013 9197 70600157
Craniocerebral injury 11.87 9.45 3 319087 4588 70604766
Pneumonia influenzal 11.83 9.45 32 319058 2578 70606776
Ulcer 11.82 9.45 172 318918 25582 70583772
Drug eruption 11.80 9.45 117 318973 39379 70569975
Pneumonia aspiration 11.79 9.45 203 318887 62086 70547268
Atrioventricular block second degree 11.79 9.45 8 319082 6770 70602584
Viral load abnormal 11.76 9.45 6 319084 67 70609287
Pseudopolyposis 11.76 9.45 6 319084 67 70609287
Urogenital disorder 11.76 9.45 6 319084 67 70609287
Evans syndrome 11.74 9.45 12 319078 422 70608932
Activated partial thromboplastin time shortened 11.72 9.45 17 319073 864 70608490
Henoch-Schonlein purpura 11.72 9.45 31 319059 2464 70606890
Terminal ileitis 11.72 9.45 15 319075 676 70608678
Hiatus hernia 11.70 9.45 52 319038 21082 70588272
Retching 11.70 9.45 35 319055 15944 70593410
Cytomegalovirus gastroenteritis 11.70 9.45 12 319078 424 70608930
Lower gastrointestinal haemorrhage 11.69 9.45 31 319059 14689 70594665
Encephalitis Japanese B 11.68 9.45 6 319084 68 70609286
Therapy partial responder 11.66 9.45 96 318994 12378 70596976
Autoimmune haemolytic anaemia 11.65 9.45 67 319023 7679 70601675
JC polyomavirus test positive 11.65 9.45 21 319069 1283 70608071
Liver abscess 11.62 9.45 53 319037 5546 70603808
Arrhythmia 11.61 9.45 180 318910 55963 70553391
Pre-existing condition improved 11.59 9.45 4 319086 4998 70604356
Eosinophil count increased 11.58 9.45 112 318978 15110 70594244
Pathergy reaction 11.57 9.45 5 319085 37 70609317
Therapy change 11.56 9.45 8 319082 6701 70602653
Acarodermatitis 11.56 9.45 21 319069 1291 70608063
Arterial spasm 11.55 9.45 8 319082 162 70609192
Trichophytosis 11.54 9.45 11 319079 355 70608999
Gastrointestinal oedema 11.54 9.45 30 319060 2360 70606994
Acanthamoeba keratitis 11.53 9.45 7 319083 112 70609242
Haptoglobin decreased 11.50 9.45 21 319069 1296 70608058
Groin pain 11.47 9.45 23 319067 12019 70597335
Optic nerve compression 11.47 9.45 4 319086 15 70609339
Skin test positive 11.46 9.45 19 319071 1085 70608269
Muscle twitching 11.46 9.45 48 319042 19779 70589575
Asthma late onset 11.45 9.45 5 319085 38 70609316
Fear of injection 11.44 9.45 8 319082 6664 70602690
Conjunctival oedema 11.43 9.45 19 319071 1087 70608267
Alternaria infection 11.43 9.45 14 319076 603 70608751
Thyroxine free decreased 11.43 9.45 18 319072 984 70608370
Viral myocarditis 11.42 9.45 12 319078 436 70608918
Herpes oesophagitis 11.41 9.45 11 319079 360 70608994
Panniculitis 11.41 9.45 19 319071 10657 70598697
Necrotising oesophagitis 11.35 9.45 15 319075 698 70608656
Hepatic cyst infection 11.34 9.45 8 319082 167 70609187
Rheumatic fever 11.33 9.45 41 319049 17619 70591735
Disseminated cytomegaloviral infection 11.31 9.45 12 319078 441 70608913
Chronic papillomatous dermatitis 11.31 9.45 6 319084 73 70609281
Granulocyte percentage 11.31 9.45 6 319084 73 70609281
Foetal growth restriction 11.30 9.45 26 319064 1893 70607461
Cardiac pacemaker insertion 11.29 9.45 5 319085 5367 70603987
Cardiac operation 11.28 9.45 3 319087 4436 70604918
Obsessive-compulsive disorder 11.28 9.45 5 319085 5365 70603989
Gastrointestinal haemorrhage 11.28 9.45 504 318586 136904 70472450
Subcutaneous emphysema 11.27 9.45 24 319066 1658 70607696
Carotid artery insufficiency 11.27 9.45 4 319086 16 70609338
Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids 11.27 9.45 4 319086 16 70609338
Mycobacterium kansasii infection 11.24 9.45 11 319079 367 70608987
Finger deformity 11.22 9.45 56 319034 6080 70603274
Endocarditis 11.20 9.45 80 319010 9874 70599480
Urinary fistula 11.17 9.45 6 319084 75 70609279
Pelvic fracture 11.17 9.45 21 319069 11240 70598114
Normal newborn 11.17 9.45 57 319033 6243 70603111
Clostridium colitis 11.17 9.45 31 319059 2535 70606819
Acne fulminans 11.17 9.45 9 319081 231 70609123
Osteoarthropathy 11.16 9.45 3 319087 3 70609351
Catheter site necrosis 11.16 9.45 3 319087 3 70609351
Blood catecholamines abnormal 11.16 9.45 3 319087 3 70609351
Meningitis listeria 11.16 9.45 17 319073 903 70608451
Abnormal behaviour 11.15 9.45 101 318989 34608 70574746
Infective myositis 11.11 9.45 7 319083 120 70609234
Dengue fever 11.09 9.45 16 319074 809 70608545
Glomerulonephritis proliferative 11.07 9.45 11 319079 374 70608980
Cytopenia 11.07 9.45 123 318967 17200 70592154
Tricuspid valve incompetence 11.01 9.45 42 319048 17775 70591579
Larynx irritation 11.01 9.45 7 319083 122 70609232
Feeling drunk 11.01 9.45 3 319087 4364 70604990
Infertility 11.00 9.45 14 319076 627 70608727
Anuria 10.98 9.45 136 318954 19517 70589837
Sodium retention 10.98 9.45 8 319082 176 70609178
Capnocytophaga infection 10.97 9.45 6 319084 78 70609276
Myelopathy 10.97 9.45 43 319047 4208 70605146
Bone disorder 10.96 9.45 41 319049 17449 70591905
Cryptococcal cutaneous infection 10.94 9.45 8 319082 177 70609177
Malacoplakia 10.93 9.45 10 319080 306 70609048
Aortic pseudoaneurysm 10.93 9.45 5 319085 43 70609311
Human herpes virus 8 test positive 10.93 9.45 5 319085 43 70609311
Meningoencephalitis herpetic 10.92 9.45 25 319065 1814 70607540
Diffuse large B-cell lymphoma stage III 10.91 9.45 7 319083 124 70609230
Nephritis 10.88 9.45 40 319050 3796 70605558
Excessive skin 10.86 9.45 7 319083 125 70609229
Acute pulmonary oedema 10.86 9.45 100 318990 13312 70596042
Ketoacidosis 10.85 9.45 10 319080 7259 70602095
Pelvic venous thrombosis 10.80 9.45 25 319065 1827 70607527
Coombs direct test positive 10.78 9.45 11 319079 386 70608968
Eye infection fungal 10.78 9.45 12 319078 466 70608888
Eye pruritus 10.78 9.45 32 319058 14615 70594739
Oxygen saturation abnormal 10.78 9.45 40 319050 3814 70605540
Megacolon 10.78 9.45 35 319055 3121 70606233
Glomerulonephropathy 10.77 9.45 10 319080 312 70609042
Idiopathic pneumonia syndrome 10.76 9.45 13 319077 552 70608802
Glomerulonephritis minimal lesion 10.75 9.45 15 319075 735 70608619
Cystitis 10.74 9.45 282 318808 46659 70562695
Bilirubin conjugated increased 10.72 9.45 49 319041 5132 70604222
Total lung capacity abnormal 10.71 9.45 8 319082 183 70609171
Urinoma 10.71 9.45 8 319082 183 70609171
Balance disorder 10.70 9.45 316 318774 89812 70519542
Gangrene 10.68 9.45 69 319021 8240 70601114
Granulocyte count increased 10.67 9.45 17 319073 939 70608415
Epidural lipomatosis 10.65 9.45 17 319073 940 70608414
Gastritis fungal 10.63 9.45 8 319082 185 70609169
Protein urine 10.63 9.45 21 319069 1375 70607979
Central venous pressure increased 10.63 9.45 7 319083 130 70609224
Abdominal abscess 10.62 9.45 58 319032 6520 70602834
Diabetic hyperosmolar coma 10.62 9.45 15 319075 744 70608610
Hyperammonaemia 10.60 9.45 81 319009 10212 70599142
Retinal scar 10.60 9.45 11 319079 394 70608960
Disseminated trichosporonosis 10.58 9.45 7 319083 131 70609223
Dysstasia 10.58 9.45 68 319022 25111 70584243
Hepatic haemorrhage 10.56 9.45 17 319073 947 70608407
Urine uric acid increased 10.55 9.45 5 319085 47 70609307
Blood cholesterol increased 10.54 9.45 216 318874 64388 70544966
Asphyxia 10.51 9.45 19 319071 10323 70599031
Jejunal perforation 10.51 9.45 10 319080 322 70609032
Migraine 10.50 9.45 246 318844 71992 70537362
Vasculitis necrotising 10.49 9.45 19 319071 1165 70608189
Pulse pressure increased 10.49 9.45 7 319083 133 70609221
Suspected COVID-19 10.48 9.45 29 319061 2367 70606987
Bulbar palsy 10.47 9.45 9 319081 253 70609101
Oral bacterial infection 10.45 9.45 5 319085 48 70609306
Carotid artery stenosis 10.44 9.45 13 319077 8223 70601131
Hepatitis viral 10.43 9.45 17 319073 957 70608397
Pancreatic carcinoma 10.39 9.45 27 319063 12877 70596477
Mean platelet volume decreased 10.38 9.45 28 319062 2251 70607103
Generalised oedema 10.37 9.45 146 318944 21562 70587792
Myocarditis infectious 10.37 9.45 5 319085 49 70609305
Human herpesvirus 6 encephalitis 10.36 9.45 12 319078 487 70608867
Acid base balance abnormal 10.36 9.45 10 319080 328 70609026
Glomerulonephritis rapidly progressive 10.35 9.45 21 319069 1402 70607952
Tuberous sclerosis complex 10.34 9.45 6 319084 88 70609266
Escherichia bacteraemia 10.34 9.45 53 319037 5816 70603538
Toxic neuropathy 10.33 9.45 16 319074 862 70608492
Cerebral venous sinus thrombosis 10.33 9.45 26 319064 2005 70607349
Adenomatous polyposis coli 10.31 9.45 8 319082 194 70609160
Tracheobronchitis 10.29 9.45 24 319066 1763 70607591
Cytomegalovirus test 10.28 9.45 5 319085 50 70609304
Ureteral necrosis 10.28 9.45 6 319084 89 70609265
Conus medullaris syndrome 10.28 9.45 5 319085 50 70609304
Eosinopenia 10.28 9.45 5 319085 50 70609304
Cavernous sinus thrombosis 10.26 9.45 10 319080 332 70609022
Metastases to central nervous system 10.25 9.45 34 319056 15000 70594354
Acute myeloid leukaemia (in remission) 10.25 9.45 4 319086 22 70609332
Metamyelocyte percentage increased 10.25 9.45 4 319086 22 70609332
Enterovirus infection 10.24 9.45 23 319067 1648 70607706
Coronary artery aneurysm 10.22 9.45 7 319083 139 70609215
Hallucination, auditory 10.21 9.45 45 319045 18283 70591071
Sexual dysfunction 10.20 9.45 9 319081 6672 70602682
Anti-cyclic citrullinated peptide antibody 10.20 9.45 36 319054 3349 70606005
Gastrointestinal scarring 10.18 9.45 9 319081 263 70609091
Palmar erythema 10.15 9.45 24 319066 1779 70607575
Mycotic endophthalmitis 10.13 9.45 7 319083 141 70609213
Glycosylated haemoglobin increased 10.11 9.45 42 319048 17349 70592005
Tongue fungal infection 10.11 9.45 5 319085 52 70609302
Chronic hepatitis C 10.05 9.45 13 319077 592 70608762
Viral myositis 10.03 9.45 5 319085 53 70609301
Viral vasculitis 10.01 9.45 7 319083 144 70609210
Papillitis 9.99 9.45 6 319084 94 70609260
Tenosynovitis stenosans 9.97 9.45 28 319062 2305 70607049
Haemangioma-thrombocytopenia syndrome 9.96 9.45 3 319087 6 70609348
Osseous cryptococcosis 9.96 9.45 3 319087 6 70609348
Renal tubular disorder 9.95 9.45 54 319036 6056 70603298
Glucose-6-phosphate dehydrogenase deficiency 9.94 9.45 10 319080 345 70609009
Alanine aminotransferase abnormal 9.92 9.45 13 319077 8046 70601308
Type 2 diabetes mellitus 9.92 9.45 139 318951 43941 70565413
Adjusted calcium decreased 9.90 9.45 8 319082 206 70609148
Hepatitis toxic 9.89 9.45 44 319046 4555 70604799
Biopsy lymph gland 9.88 9.45 6 319084 96 70609258
Diverticulum intestinal 9.87 9.45 13 319077 8028 70601326
Chronic graft versus host disease in skin 9.87 9.45 21 319069 1450 70607904
Cardiovascular disorder 9.86 9.45 40 319050 16630 70592724
Blood magnesium decreased 9.82 9.45 34 319056 14807 70594547
Normochromic anaemia 9.81 9.45 11 319079 431 70608923
Meniscus injury 9.80 9.45 8 319082 6159 70603195
Gastrointestinal perforation 9.79 9.45 51 319039 5630 70603724
Cerebellar ataxia 9.79 9.45 24 319066 1820 70607534
Impaired work ability 9.79 9.45 39 319051 16301 70593053
Pancreatitis 9.79 9.45 211 318879 62457 70546897
Pulmonary cavitation 9.78 9.45 21 319069 1459 70607895
Moraxella infection 9.78 9.45 12 319078 518 70608836
Wrong product administered 9.75 9.45 14 319076 8337 70601017
Retinal vasculitis 9.74 9.45 19 319071 1233 70608121
Laboratory test abnormal 9.73 9.45 72 319018 25751 70583603
Gastric haemorrhage 9.73 9.45 32 319058 14153 70595201
Nosocomial infection 9.72 9.45 30 319060 2603 70606751
Epstein-Barr virus antibody positive 9.72 9.45 13 319077 612 70608742
Blood urea increased 9.71 9.45 273 318817 45636 70563718
Angina pectoris 9.71 9.45 156 318934 48227 70561127
Hypovolaemia 9.69 9.45 38 319052 15955 70593399
Biliary ischaemia 9.69 9.45 4 319086 26 70609328
Complications of transplanted pancreas 9.69 9.45 4 319086 26 70609328
Libido decreased 9.68 9.45 5 319085 4911 70604443
Complication of device insertion 9.67 9.45 6 319084 5326 70604028
Panic attack 9.67 9.45 59 319031 22060 70587294
Haemodialysis 9.63 9.45 120 318970 17246 70592108
Vascular rupture 9.63 9.45 21 319069 1475 70607879
Blood calcium increased 9.62 9.45 16 319074 8977 70600377
Interleukin-2 receptor increased 9.61 9.45 8 319082 215 70609139
Spinal fusion surgery 9.61 9.45 3 319087 3994 70605360
Superinfection bacterial 9.61 9.45 19 319071 1245 70608109
Stent placement 9.59 9.45 8 319082 6093 70603261
Synovial fluid analysis 9.58 9.45 24 319066 1845 70607509
Castleman's disease 9.57 9.45 4 319086 27 70609327
Liver function test 9.57 9.45 7 319083 155 70609199
Mucocutaneous leishmaniasis 9.54 9.45 11 319079 444 70608910
Complement factor C3 decreased 9.53 9.45 10 319080 363 70608991
Nose deformity 9.53 9.45 7 319083 156 70609198
Meningitis 9.51 9.45 70 319020 8723 70600631
Type 1 diabetes mellitus 9.51 9.45 54 319036 6160 70603194
Nail bed inflammation 9.49 9.45 12 319078 534 70608820
Bundle branch block right 9.49 9.45 21 319069 10589 70598765
Tooth loss 9.48 9.45 9 319081 6441 70602913
Exercise tolerance decreased 9.46 9.45 14 319076 8234 70601120

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000932 Antiemetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D018696 Neuroprotective Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D020011 Protective Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018931 Antineoplastic Agents, Hormonal
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:37962 adrenergic agents
CHEBI has role CHEBI:50919 antiemetico
CHEBI has role CHEBI:63726 neuroprotective agents
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Nephrotic syndrome indication 52254009 DOID:1184




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.23 acidic
pKa2 12.63 acidic
pKa3 13.35 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL

External reference:

IDSource
4018069 VUID
N0000179635 NUI
D00751 KEGG_DRUG
2375-03-3 SECONDARY_CAS_RN
4018068 VANDF
4018069 VANDF
C0025819 UMLSCUI
CHEBI:135765 CHEBI
CHEBI:6888 CHEBI
CHEMBL1201265 ChEMBL_ID
CHEMBL1201081 ChEMBL_ID
DB14644 DRUGBANK_ID
23680530 PUBCHEM_CID
DB00959 DRUGBANK_ID
203189 RXNORM
1041 MMSL
4854 MMSL
5093 MMSL
5095 MMSL
d00293 MMSL
002160 NDDF
002162 NDDF
005280 NDDF
116593003 SNOMEDCT_US
27242001 SNOMEDCT_US
412248005 SNOMEDCT_US
734654003 SNOMEDCT_US
D008776 MESH_DESCRIPTOR_UI
C0025815 UMLSCUI
732 INN_ID
D008775 MESH_DESCRIPTOR_UI
6741 PUBCHEM_CID
5GMR90S4KN UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
SOLU-MEDROL HUMAN PRESCRIPTION DRUG LABEL 1 0009-0003 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS NDA 22 sections
SOLU-MEDROL HUMAN PRESCRIPTION DRUG LABEL 1 0009-0018 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS NDA 22 sections
SOLU-MEDROL HUMAN PRESCRIPTION DRUG LABEL 1 0009-0039 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS NDA 22 sections
SOLU-MEDROL HUMAN PRESCRIPTION DRUG LABEL 1 0009-0039 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS NDA 22 sections
SOLU-MEDROL HUMAN PRESCRIPTION DRUG LABEL 1 0009-0047 INJECTION, POWDER, FOR SOLUTION 125 mg INTRAVENOUS NDA 22 sections
SOLU-MEDROL HUMAN PRESCRIPTION DRUG LABEL 1 0009-0047 INJECTION, POWDER, FOR SOLUTION 125 mg INTRAVENOUS NDA 22 sections
SOLU-MEDROL HUMAN PRESCRIPTION DRUG LABEL 1 0009-0698 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS NDA 22 sections
SOLU-MEDROL HUMAN PRESCRIPTION DRUG LABEL 1 0009-0698 INJECTION, POWDER, FOR SOLUTION 1 g INTRAVENOUS NDA 22 sections
SOLU-MEDROL HUMAN PRESCRIPTION DRUG LABEL 1 0009-0758 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAVENOUS NDA 22 sections
SOLU-MEDROL HUMAN PRESCRIPTION DRUG LABEL 1 0009-0850 INJECTION, POWDER, FOR SOLUTION 2 g INTRAVENOUS NDA 22 sections
Methylprednisolone Sodium Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9850 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAMUSCULAR ANDA 22 sections
Methylprednisolone Sodium Succinate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9851 INJECTION, POWDER, FOR SOLUTION 1 g INTRAMUSCULAR ANDA 22 sections
Solu-Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0404-9957 INJECTION, POWDER, FOR SOLUTION 125 mg INTRAVENOUS NDA 13 sections
Solu-Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0404-9957 INJECTION, POWDER, FOR SOLUTION 125 mg INTRAVENOUS NDA 13 sections
Solu-Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0404-9958 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS NDA 13 sections
Solu-Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0404-9958 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS NDA 13 sections
Methylprednisolone sodium succinate HUMAN PRESCRIPTION DRUG LABEL 1 43598-127 INJECTION 40 mg INTRAVENOUS ANDA 19 sections
Methylprednisolone sodium succinate HUMAN PRESCRIPTION DRUG LABEL 1 43598-128 INJECTION 500 mg INTRAVENOUS ANDA 19 sections
Methylprednisolone sodium succinate HUMAN PRESCRIPTION DRUG LABEL 1 43598-129 INJECTION 125 mg INTRAVENOUS ANDA 19 sections
Methylprednisolone sodium succinate HUMAN PRESCRIPTION DRUG LABEL 1 43598-130 INJECTION 1 g INTRAVENOUS ANDA 19 sections
SOLU-MEDROL HUMAN PRESCRIPTION DRUG LABEL 1 50090-0271 INJECTION, POWDER, FOR SOLUTION 125 mg INTRAVENOUS NDA 22 sections
SOLU-MEDROL HUMAN PRESCRIPTION DRUG LABEL 1 50090-2253 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS NDA 22 sections
SOLU-MEDROL HUMAN PRESCRIPTION DRUG LABEL 1 51662-1263 INJECTION, POWDER, FOR SOLUTION 125 mg INTRAMUSCULAR NDA 13 sections
SOLU-MEDROL HUMAN PRESCRIPTION DRUG LABEL 1 51662-1264 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAMUSCULAR NDA 13 sections
SOLU-MEDROL(R) METHYLPREDNISOLONE SODIUM SUCCINAT HUMAN PRESCRIPTION DRUG LABEL 1 51662-1483 INJECTION, POWDER, FOR SOLUTION 500 mg INTRAMUSCULAR NDA 13 sections
Solu-Medrol HUMAN PRESCRIPTION DRUG LABEL 1 52584-039 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS NDA 13 sections
Solu-Medrol HUMAN PRESCRIPTION DRUG LABEL 1 52584-047 INJECTION, POWDER, FOR SOLUTION 125 mg INTRAVENOUS NDA 14 sections
Solu-Medrol HUMAN PRESCRIPTION DRUG LABEL 1 52584-047 INJECTION, POWDER, FOR SOLUTION 125 mg INTRAVENOUS NDA 14 sections
Methylprednisolone Sodium Succinate Human Prescription Drug Label 1 55150-262 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 40 mg INTRAMUSCULAR ANDA 20 sections
Methylprednisolone Sodium Succinate Human Prescription Drug Label 1 55150-263 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 125 mg INTRAMUSCULAR ANDA 20 sections