methylprednisolone succinate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
prednisone and prednisolone derivatives	1771	2921-57-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: methylprednisolone succinate methylprednisolone hemisuccinate methylprednisolone sodium succinate	A water-soluble ester of METHYLPREDNISOLONE used for cardiac, allergic, and hypoxic emergencies. Molecular weight: 474.55 Formula: C26H34O8 CLOGP: 2.05 LIPINSKI: 0 HAC: 8 HDO: 3 TPSA: 138.20 ALOGS: -4.25 ROTB: 7 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

methylprednisolone succinate
methylprednisolone hemisuccinate
methylprednisolone sodium succinate

A water-soluble ester of METHYLPREDNISOLONE used for cardiac, allergic, and hypoxic emergencies.

Molecular weight: 474.55
Formula: C26H34O8
CLOGP: 2.05
LIPINSKI: 0
HAC: 8
HDO: 3
TPSA: 138.20
ALOGS: -4.25
ROTB: 7

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
S (Water solubility)	0.12 mg/mL	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
May 18, 1959	FDA	PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cytomegalovirus infection	837.98	9.78	674	243864	20278	63224206
Off label use	719.65	9.78	4743	239795	669719	62574765
Blood pressure fluctuation	591.73	9.78	808	243730	45509	63198975
Infusion related reaction	543.20	9.78	2124	242414	243397	63001087
Completed suicide	499.75	9.78	13	244525	145660	63098824
Product use in unapproved indication	411.01	9.78	1568	242970	177512	63066972
Oxygen saturation decreased	409.86	9.78	993	243545	87592	63156892
Blood pressure diastolic abnormal	407.62	9.78	382	244156	14160	63230324
Drug ineffective for unapproved indication	395.94	9.78	568	243970	33495	63210989
Blood pressure systolic abnormal	387.49	9.78	358	244180	13028	63231456

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Off label use	1167.31	10.72	4244	148747	415280	34388660
Cytomegalovirus infection	879.79	10.72	804	152187	25331	34778609
Drug ineffective for unapproved indication	522.51	10.72	580	152411	23135	34780805
Product use in unapproved indication	477.30	10.72	1358	151633	116141	34687799
Death	420.44	10.72	686	152305	397363	34406577
Infusion related reaction	408.05	10.72	788	152203	52269	34751671
Drug ineffective	385.24	10.72	3351	149640	453400	34350540
Transplant rejection	350.25	10.72	319	152672	9992	34793948
Drug abuse	346.67	10.72	22	152969	99074	34704866
Completed suicide	345.80	10.72	21	152970	98147	34705793

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Off label use	1781.45	9.53	8447	352260	898768	78484913
Cytomegalovirus infection	1502.77	9.53	1366	359341	41278	79342403
Completed suicide	967.76	9.53	32	360675	245735	79137946
Product use in unapproved indication	883.76	9.53	2814	357893	247545	79136136
Drug ineffective for unapproved indication	850.57	9.53	1103	359604	50135	79333546
Infusion related reaction	825.44	9.53	2602	358105	227635	79156046
Blood pressure fluctuation	699.23	9.53	1160	359547	65985	79317696
Toxicity to various agents	614.23	9.53	601	360106	420939	78962742
Transplant rejection	589.32	9.53	573	360134	18864	79364817
Drug ineffective	571.74	9.53	7416	353291	1073497	78310184

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
CHEBI has role	CHEBI:35472	anti-inflammatory drugs
CHEBI has role	CHEBI:35703	Xenobiotic
CHEBI has role	CHEBI:37962	adrenergic agents
CHEBI has role	CHEBI:50919	antiemetico
CHEBI has role	CHEBI:63726	neuroprotective agents
CHEBI has role	CHEBI:78298	environmental contaminants
FDA EPC	N0000175576	Corticosteroid
FDA MoA	N0000175450	Corticosteroid Hormone Receptor Agonists
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D000932	Antiemetics

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Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Nephrotic syndrome	indication	52254009	DOID:1184

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.23	acidic
pKa2	12.63	acidic
pKa3	13.35	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN	AGONIST				CHEMBL	CHEMBL

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External reference:

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ID	Source
002160	NDDF
002162	NDDF
005280	NDDF
1041	MMSL
116593003	SNOMEDCT_US
16923	PUBCHEM_CID
203189	RXNORM
2375-03-3	SECONDARY_CAS_RN
27242001	SNOMEDCT_US
4018068	VANDF

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Methylprednisolone Sodium Succinate	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9753	INJECTION, POWDER, FOR SOLUTION	40 mg	INTRAMUSCULAR	ANDA	20 sections
Methylprednisolone Sodium Succinate	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9754	INJECTION, POWDER, FOR SOLUTION	125 mg	INTRAMUSCULAR	ANDA	20 sections
Methylprednisolone Sodium Succinate	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9850	INJECTION, POWDER, FOR SOLUTION	500 mg	INTRAMUSCULAR	ANDA	22 sections
Methylprednisolone Sodium Succinate	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9851	INJECTION, POWDER, FOR SOLUTION	1 g	INTRAMUSCULAR	ANDA	22 sections
Methylprednisolone sodium succinate	HUMAN PRESCRIPTION DRUG LABEL	1	43598-127	INJECTION	40 mg	INTRAVENOUS	ANDA	19 sections
Methylprednisolone sodium succinate	HUMAN PRESCRIPTION DRUG LABEL	1	43598-128	INJECTION	500 mg	INTRAVENOUS	ANDA	19 sections
Methylprednisolone sodium succinate	HUMAN PRESCRIPTION DRUG LABEL	1	43598-129	INJECTION	125 mg	INTRAVENOUS	ANDA	19 sections
Methylprednisolone sodium succinate	HUMAN PRESCRIPTION DRUG LABEL	1	43598-130	INJECTION	1 g	INTRAVENOUS	ANDA	19 sections
SOLU-MEDROL	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0003	INJECTION, POWDER, FOR SOLUTION	500 mg	INTRAVENOUS	NDA	22 sections
SOLU-MEDROL	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0018	INJECTION, POWDER, FOR SOLUTION	1 g	INTRAVENOUS	NDA	22 sections

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