methylprednisolone acetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
prednisone and prednisolone derivatives	1770	53-36-1

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: methylprednisolone acetate depo-methylprednisolone medrol acetate	Methylprednisolone derivative that is used as an anti-inflammatory agent for the treatment of ALLERGY and ALLERGIC RHINITIS; ASTHMA; and BURSITIS; and for the treatment of ADRENAL INSUFFICIENCY. Molecular weight: 416.51 Formula: C24H32O6 CLOGP: 2.28 LIPINSKI: 0 HAC: 6 HDO: 2 TPSA: 100.90 ALOGS: -4.33 ROTB: 4 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

methylprednisolone acetate
depo-methylprednisolone
medrol acetate

Methylprednisolone derivative that is used as an anti-inflammatory agent for the treatment of ALLERGY and ALLERGIC RHINITIS; ASTHMA; and BURSITIS; and for the treatment of ADRENAL INSUFFICIENCY.

Molecular weight: 416.51
Formula: C24H32O6
CLOGP: 2.28
LIPINSKI: 0
HAC: 6
HDO: 2
TPSA: 100.90
ALOGS: -4.33
ROTB: 4

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
S (Water solubility)	0.12 mg/mL	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
May 27, 1959	FDA	PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Temperature regulation disorder	449.74	19.23	141	22391	5991	63460499
Bursitis	394.28	19.23	213	22319	36828	63429662
Food allergy	367.71	19.23	142	22390	11259	63455231
Coeliac disease	341.49	19.23	139	22393	12658	63453832
Immunodeficiency	298.24	19.23	145	22387	20109	63446381
Synovial cyst	287.55	19.23	116	22416	10317	63456173
Upper respiratory tract infection	269.16	19.23	227	22305	81820	63384670
Rheumatoid arthritis	243.15	19.23	369	22163	253450	63213040
Pulmonary toxicity	216.16	19.23	92	22440	9363	63457127
Rash erythematous	207.72	19.23	149	22383	42361	63424129
Tenderness	202.29	19.23	116	22416	22462	63444028
Crepitations	189.67	19.23	80	22452	7960	63458530
Tenosynovitis	185.88	19.23	93	22439	13702	63452788
Bone density decreased	177.93	19.23	92	22440	14520	63451970
Tenosynovitis stenosans	176.30	19.23	60	22472	3304	63463186
Dry eye	170.21	19.23	130	22402	40631	63425859
Allergy to chemicals	162.34	19.23	55	22477	2987	63463503
Synovial fluid analysis	162.02	19.23	52	22480	2381	63464109
Joint effusion	159.12	19.23	90	22442	16970	63449520
Scleritis	156.55	19.23	59	22473	4369	63462121
Fluid retention	153.52	19.23	144	22388	59542	63406948
Erythema	153.31	19.23	245	22287	175506	63290984
Joint range of motion decreased	147.78	19.23	109	22423	32319	63434171
Rheumatoid nodule	129.69	19.23	79	22453	17076	63449414
Musculoskeletal stiffness	128.75	19.23	233	22299	184385	63282105
Pleuritic pain	125.76	19.23	60	22472	7969	63458521
Joint swelling	124.22	19.23	323	22209	327343	63139147
Cushingoid	116.65	19.23	58	22474	8427	63458063
Fibromyalgia	116.28	19.23	143	22389	80277	63386213
Musculoskeletal pain	115.93	19.23	153	22379	92124	63374366
Hyperhidrosis	108.92	19.23	161	22371	107675	63358815
Conjunctivitis	106.38	19.23	75	22457	20721	63445769
Antinuclear antibody positive	105.02	19.23	53	22479	7946	63458544
Rash maculo-papular	103.92	19.23	88	22444	31808	63434682
Gangrene	102.78	19.23	48	22484	6075	63460415
Treatment failure	102.21	19.23	221	22311	198822	63267668
Arterial occlusive disease	100.92	19.23	47	22485	5911	63460579
Rheumatoid lung	99.88	19.23	41	22491	3807	63462683
Spinal stenosis	98.36	19.23	63	22469	14862	63451628
Photophobia	98.18	19.23	67	22465	17568	63448922
Back pain	94.50	19.23	255	22277	263890	63202600
Feeling jittery	94.38	19.23	59	22473	13344	63453146
Asthma	87.57	19.23	160	22372	127401	63339089
Impaired work ability	87.01	19.23	62	22470	17413	63449077
Pain	86.29	19.23	501	22031	740127	62726363
Deformity	86.24	19.23	53	22479	11631	63454859
Cataract	84.95	19.23	103	22429	56950	63409540
Flank pain	83.51	19.23	59	22473	16351	63450139
Atelectasis	79.86	19.23	64	22468	21419	63445071
Viral upper respiratory tract infection	75.41	19.23	42	22490	7682	63458808
Arthritis	74.04	19.23	141	22391	115780	63350710
Drug hypersensitivity	72.08	19.23	258	22274	310429	63156061
Nodule	70.52	19.23	59	22473	20967	63445523
Death	69.80	19.23	23	22509	374358	63092132
Ocular hyperaemia	69.12	19.23	63	22469	25081	63441409
Rash pruritic	68.73	19.23	95	22437	59704	63406786
Meningitis fungal	67.69	19.23	13	22519	61	63466429
Eye irritation	66.24	19.23	58	22474	21913	63444577
Ulcer	63.29	19.23	61	22471	26046	63440444
Alopecia	60.72	19.23	22	22510	337514	63128976
Muscular weakness	58.36	19.23	132	22400	122221	63344269
Product contamination	57.89	19.23	18	22514	742	63465748
Grip strength decreased	57.69	19.23	54	22478	22233	63444257
Hepatic enzyme increased	57.49	19.23	180	22352	202148	63264342
Rotator cuff repair	56.28	19.23	23	22509	2111	63464379
Lung disorder	53.06	19.23	86	22446	62175	63404315
C-reactive protein increased	52.98	19.23	109	22423	94598	63371892
Neoplasm malignant	52.95	19.23	59	22473	29802	63436688
Eye pain	51.81	19.23	62	22470	33792	63432698
Acute kidney injury	51.18	19.23	15	22517	263400	63203090
Arthritis bacterial	49.44	19.23	30	22502	6433	63460057
Glossodynia	48.50	19.23	4	22528	178872	63287618
Systemic lupus erythematosus	48.43	19.23	8	22524	208910	63257580
Neurologic neglect syndrome	47.75	19.23	22	22510	2699	63463791
Pemphigus	47.44	19.23	5	22527	183721	63282769
Carotid artery thrombosis	47.19	19.23	22	22510	2772	63463718
Foetal death	45.75	19.23	35	22497	10945	63455545
Prescribed overdose	44.97	19.23	58	22474	34095	63432395
Drug interaction	42.79	19.23	14	22518	229117	63237373
Product dose omission issue	42.57	19.23	15	22517	234298	63232192
Toxicity to various agents	41.34	19.23	18	22514	247232	63219258
Anaemia	40.82	19.23	27	22505	293403	63173087
Angina pectoris	39.47	19.23	51	22481	30027	63436463
Lip and/or oral cavity cancer	39.28	19.23	14	22518	884	63465606
Vomiting	39.25	19.23	88	22444	559529	62906961
Interstitial lung disease	39.12	19.23	75	22457	61833	63404657
Peripheral swelling	38.94	19.23	192	22340	265750	63200740
Osteoarthritis	38.03	19.23	96	22436	95247	63371243
Visual impairment	37.92	19.23	89	22443	84357	63382133
Vaginal haematoma	37.66	19.23	9	22523	134	63466356
Sensory loss	36.98	19.23	30	22502	10208	63456282
Constipation	36.26	19.23	167	22365	224776	63241714
Maternal exposure during pregnancy	35.26	19.23	17	22515	220045	63246445
Joint noise	35.18	19.23	21	22511	4371	63462119
Pain in extremity	34.96	19.23	219	22313	331267	63135223
Alanine aminotransferase abnormal	34.69	19.23	21	22511	4483	63462007
Bone density abnormal	34.60	19.23	19	22513	3379	63463111
Synovial disorder	34.22	19.23	16	22516	2029	63464461
Parapsoriasis	33.73	19.23	8	22524	115	63466375
Drug intolerance	32.59	19.23	204	22328	308457	63158033
Contraindicated product administered	32.46	19.23	158	22374	217490	63249000
Decreased appetite	32.42	19.23	25	22507	251027	63215463
Personality disorder	32.15	19.23	22	22510	5789	63460701
Psoriasis	32.05	19.23	85	22447	86872	63379618
Hypotension	31.72	19.23	30	22502	272574	63193916
Somnolence	31.50	19.23	12	22520	178673	63287817
Dry mouth	30.63	19.23	78	22454	77785	63388705
Disease progression	30.05	19.23	4	22528	122754	63343736
Blister	30.00	19.23	5	22527	129809	63336681
Middle lobe syndrome	29.86	19.23	6	22526	37	63466453
Gastric disorder	29.65	19.23	50	22482	37319	63429171
Incorrect route of product administration	29.13	19.23	42	22490	27410	63439080
Abdominal discomfort	29.11	19.23	43	22489	320842	63145648
Carpal tunnel syndrome	28.42	19.23	36	22496	20781	63445709
Myalgia	28.36	19.23	115	22417	146414	63320076
Malaise	27.98	19.23	247	22285	415707	63050783
Connective tissue inflammation	27.97	19.23	6	22526	53	63466437
Skin haemorrhage	27.16	19.23	25	22507	10069	63456421
Hemiplegia	26.87	19.23	24	22508	9299	63457191
Liver disorder	26.78	19.23	59	22473	53628	63412862
Fatigue	26.21	19.23	451	22081	887577	62578913
Neutropenia	25.85	19.23	15	22517	174990	63291500
Thrombosis	25.60	19.23	65	22467	64690	63401800
Swelling face	25.39	19.23	64	22468	63411	63403079
Liver function test abnormal	25.23	19.23	54	22478	48127	63418363
Osteopenia	25.11	19.23	33	22499	19752	63446738
Stomatitis	24.98	19.23	9	22523	138716	63327774
Paraplegia	24.64	19.23	14	22518	2658	63463832
Dehydration	24.02	19.23	16	22516	173338	63293152
Hypersensitivity	23.52	19.23	181	22351	292504	63173986
Affect lability	23.23	19.23	24	22508	11127	63455363
Cardiac failure congestive	22.65	19.23	3	22529	92430	63374060
Adjustment disorder	22.39	19.23	14	22518	3164	63463326
Diverticulum oesophageal	22.36	19.23	6	22526	145	63466345
Coordination abnormal	22.35	19.23	26	22506	13747	63452743
Feeling abnormal	22.30	19.23	108	22424	148284	63318206
Wrong product administered	22.19	19.23	18	22514	6123	63460367
Motor dysfunction	22.12	19.23	23	22509	10738	63455752
Red blood cell count decreased	21.79	19.23	46	22486	40599	63425891
Cardiac failure	21.59	19.23	3	22529	89139	63377351
Arachnoiditis	21.51	19.23	7	22525	335	63466155
Impaired healing	21.49	19.23	5	22527	102537	63363953
Headache	21.37	19.23	329	22203	632912	62833578
Mandibular mass	21.25	19.23	6	22526	176	63466314
Febrile neutropenia	20.79	19.23	8	22524	118441	63348049
Benign neoplasm	20.57	19.23	9	22523	978	63465512
Blood pressure abnormal	20.30	19.23	26	22506	15172	63451318
Injection site infection	20.16	19.23	11	22521	1932	63464558
Product contamination microbial	20.16	19.23	6	22526	213	63466277
Dyspnoea	20.05	19.23	145	22387	661168	62805322
Anaphylactic reaction	19.84	19.23	60	22472	66040	63400450
Disability	19.36	19.23	28	22504	18319	63448171
Thalassaemia minor	19.35	19.23	4	22528	29	63466461
Poor venous access	19.29	19.23	25	22507	14760	63451730

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Joint swelling	200.32	19.40	118	4925	59772	34892116
Musculoskeletal stiffness	158.64	19.40	93	4950	46587	34905301
Vitamin D deficiency	118.11	19.40	42	5001	6566	34945322
Arthralgia	105.75	19.40	126	4917	169915	34781973
C-reactive protein decreased	86.87	19.40	25	5018	1977	34949911
Gastrointestinal disorder	80.75	19.40	54	4989	33894	34917994
Synovitis	78.45	19.40	39	5004	14027	34937861
Drug ineffective	71.21	19.40	183	4860	456568	34495320
Drug intolerance	59.67	19.40	57	4986	59513	34892375
Dental caries	59.56	19.40	23	5020	4516	34947372
Rash vesicular	54.76	19.40	19	5024	2758	34949130
Muscle strain	51.64	19.40	20	5023	3956	34947932
Colitis	51.44	19.40	43	5000	37707	34914181
Haematochezia	51.34	19.40	47	4996	46487	34905401
Cutaneous symptom	50.12	19.40	11	5032	285	34951603
Peripheral swelling	49.47	19.40	58	4985	76483	34875405
Diabetes mellitus inadequate control	48.72	19.40	28	5015	13436	34938452
Drug hypersensitivity	48.72	19.40	59	4984	80470	34871418
Febrile bone marrow aplasia	46.46	19.40	23	5020	8186	34943702
Rheumatoid arthritis	42.91	19.40	39	5004	38199	34913689
Incorrect route of product administration	41.11	19.40	26	5017	14819	34937069
Meningitis tuberculous	40.95	19.40	11	5032	674	34951214
Spinal pain	40.92	19.40	19	5024	5870	34946018
Meningitis	37.97	19.40	17	5026	4830	34947058
Arthritis bacterial	37.12	19.40	17	5026	5089	34946799
Pain	34.71	19.40	85	4958	204590	34747298
Pain in extremity	32.26	19.40	62	4981	126451	34825437
Myocardial oedema	30.38	19.40	7	5036	227	34951661
Herpes simplex	29.75	19.40	15	5028	5544	34946344
Chorioretinopathy	28.60	19.40	10	5033	1483	34950405
Pulmonary fibrosis	27.22	19.40	22	5021	18374	34933514
Pulmonary mass	27.15	19.40	19	5024	12793	34939095
Off label use	26.60	19.40	125	4918	419399	34532489
Psoriasis	26.02	19.40	30	5013	38782	34913106
Joint range of motion decreased	25.89	19.40	15	5028	7297	34944591
Sacroiliitis	24.79	19.40	9	5034	1489	34950399
Swelling	23.90	19.40	30	5013	42336	34909552
Meningitis fungal	23.56	19.40	5	5038	110	34951778
Mycobacterium kansasii infection	23.02	19.40	6	5037	327	34951561
Joint effusion	22.05	19.40	12	5031	5181	34946707
Wrong product administered	21.75	19.40	12	5031	5322	34946566
Blood pressure fluctuation	21.24	19.40	22	5021	25227	34926661
Condition aggravated	20.89	19.40	68	4975	192128	34759760
Arthritis infective	20.60	19.40	10	5033	3409	34948479
Weight increased	20.58	19.40	43	5000	92990	34858898
Paralysis	20.28	19.40	12	5031	6070	34945818
Injection site infection	20.15	19.40	7	5036	1019	34950869

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Temperature regulation disorder	448.16	17.67	134	23940	5719	79714595
Bursitis	397.86	17.67	201	23873	35643	79684671
Food allergy	370.99	17.67	135	23939	10689	79709625
Coeliac disease	357.39	17.67	133	23941	11218	79709096
Rheumatoid arthritis	355.69	17.67	373	23701	208097	79512217
Immunodeficiency	289.07	17.67	138	23936	21630	79698684
Joint swelling	242.26	17.67	362	23712	288284	79432030
Synovial cyst	238.70	17.67	96	23978	9969	79710345
Musculoskeletal stiffness	217.73	17.67	266	23808	174742	79545572
Upper respiratory tract infection	216.88	17.67	196	23878	90972	79629342
Tenderness	206.48	17.67	113	23961	23529	79696785
Rash erythematous	186.29	17.67	148	23926	57621	79662693
Tenosynovitis stenosans	178.63	17.67	57	24017	3021	79717293
Pain	167.20	17.67	528	23546	703274	79017040
Joint effusion	165.36	17.67	89	23985	17925	79702389
Synovial fluid analysis	163.34	17.67	50	24024	2309	79718005
Pulmonary toxicity	159.71	17.67	78	23996	12836	79707478
Scleritis	159.22	17.67	57	24017	4299	79716015
Tenosynovitis	154.49	17.67	81	23993	15473	79704841
Bone density decreased	151.36	17.67	76	23998	13271	79707043
Dry eye	141.81	17.67	105	23969	36826	79683488
Joint range of motion decreased	140.00	17.67	100	23974	33182	79687132
Fluid retention	137.07	17.67	135	23939	69674	79650640
Drug hypersensitivity	130.33	17.67	282	23792	298634	79421680
Erythema	130.25	17.67	238	23836	223052	79497262
Fibromyalgia	129.25	17.67	126	23948	64214	79656100
Crepitations	128.37	17.67	62	24012	9955	79710359
Pleuritic pain	115.68	17.67	58	24016	10094	79710220
Allergy to chemicals	114.11	17.67	39	24035	2563	79717751
Cushingoid	113.06	17.67	56	24018	9496	79710818
Antinuclear antibody positive	107.69	17.67	51	24023	7839	79712475
Spinal stenosis	104.47	17.67	63	24011	15728	79704586
Treatment failure	103.53	17.67	185	23889	170301	79550013
Feeling jittery	100.16	17.67	57	24017	12784	79707530
Musculoskeletal pain	99.66	17.67	138	23936	102216	79618098
Conjunctivitis	96.21	17.67	72	24002	25643	79694671
Rheumatoid lung	95.52	17.67	39	24035	4206	79716108
Photophobia	94.04	17.67	65	24009	20463	79699851
Back pain	93.75	17.67	251	23823	303929	79416385
Rheumatoid nodule	91.33	17.67	60	24014	17378	79702936
Gangrene	89.91	17.67	47	24027	8917	79711397
Arterial occlusive disease	89.60	17.67	46	24028	8410	79711904
Asthma	87.70	17.67	151	23923	134944	79585370
Cataract	86.27	17.67	100	23974	62020	79658294
Death	85.79	17.67	32	24042	566482	79153832
Hyperhidrosis	82.64	17.67	157	23917	151335	79568979
Arthritis	82.01	17.67	134	23940	114746	79605568
Contraindicated product administered	81.94	17.67	160	23914	157378	79562936
Drug intolerance	80.39	17.67	217	23857	263902	79456412
Impaired work ability	80.15	17.67	58	24016	19623	79700691
Hepatic enzyme increased	79.12	17.67	172	23902	182438	79537876
Flank pain	77.46	17.67	57	24017	19787	79700527
Acute kidney injury	75.88	17.67	31	24043	519373	79200941
Eye irritation	73.15	17.67	56	24018	20625	79699689
Viral upper respiratory tract infection	72.91	17.67	41	24033	8985	79711329
Peripheral swelling	72.69	17.67	212	23862	269405	79450909
Toxicity to various agents	70.49	17.67	20	24054	421520	79298794
Arthritis bacterial	69.64	17.67	40	24034	9126	79711188
C-reactive protein decreased	68.65	17.67	27	24047	2641	79717673
Nodule	67.91	17.67	56	24018	22938	79697376
Ocular hyperaemia	67.68	17.67	61	24013	28145	79692169
Ulcer	66.43	17.67	62	24012	29910	79690404
Grip strength decreased	66.14	17.67	54	24020	21815	79698499
Atelectasis	64.42	17.67	63	24011	32194	79688120
Meningitis fungal	62.45	17.67	14	24060	184	79720130
Deformity	60.14	17.67	37	24037	9568	79710746
Pain in extremity	59.11	17.67	242	23832	364296	79356018
Drug interaction	58.65	17.67	26	24048	415157	79305157
Rash maculo-papular	58.16	17.67	78	23996	56000	79664314
Neoplasm malignant	57.77	17.67	59	24015	31751	79688563
Osteoarthritis	55.85	17.67	97	23977	87212	79633102
Product contamination	55.70	17.67	19	24055	1241	79719073
Rotator cuff repair	55.52	17.67	21	24053	1849	79718465
Synovitis	54.24	17.67	132	23942	150602	79569712
Vitamin D deficiency	53.45	17.67	40	24034	14239	79706075
Eye pain	51.33	17.67	60	24014	37518	79682796
Foetal death	50.40	17.67	31	24043	8013	79712301
Rash pruritic	49.00	17.67	82	23992	71547	79648767
Neurologic neglect syndrome	46.56	17.67	21	24053	2886	79717428
Incorrect route of product administration	46.43	17.67	55	24019	34874	79685440
Carotid artery thrombosis	45.58	17.67	21	24053	3032	79717282
Synovial disorder	43.87	17.67	18	24056	1965	79718349
Psoriasis	41.77	17.67	87	23987	89500	79630814
Arthralgia	41.60	17.67	305	23769	571498	79148816
Anaemia	41.40	17.67	44	24030	444971	79275343
Prescribed overdose	41.29	17.67	54	24020	37829	79682485
Visual impairment	41.25	17.67	88	23986	92043	79628271
Bone density abnormal	39.38	17.67	19	24055	3041	79717273
Hypersensitivity	39.26	17.67	170	23904	262069	79458245
Vaginal haematoma	39.17	17.67	9	24065	133	79720181
Sensory loss	39.11	17.67	32	24042	12959	79707355
Vomiting	38.95	17.67	90	23984	665738	79054576
Ankylosing spondylitis	38.73	17.67	31	24043	12174	79708140
Drug ineffective	38.60	17.67	496	23578	1080417	78639897
Lip and/or oral cavity cancer	38.56	17.67	14	24060	1099	79719215
Spinal pain	38.33	17.67	34	24040	15358	79704956
Decreased appetite	37.63	17.67	29	24045	342389	79377925
Neutropenia	37.58	17.67	20	24054	287690	79432624
Hypotension	37.22	17.67	47	24027	440270	79280044
Product dose omission issue	35.72	17.67	15	24059	247522	79472792
Gastric disorder	35.69	17.67	50	24024	37383	79682931
Somnolence	35.26	17.67	14	24060	238967	79481347
Joint noise	34.69	17.67	19	24055	3955	79716359
Muscular weakness	34.60	17.67	117	23957	160612	79559702
Headache	34.30	17.67	324	23750	653448	79066866
Dehydration	34.30	17.67	16	24058	248171	79472143
Meningitis	34.00	17.67	26	24048	9556	79710758
Febrile neutropenia	33.32	17.67	14	24060	230985	79489329
Osteopenia	33.23	17.67	34	24040	18330	79701984
Disease progression	32.19	17.67	8	24066	184354	79535960
Hand deformity	32.16	17.67	86	23988	103833	79616481
Personality disorder	31.82	17.67	21	24053	6125	79714189
Middle lobe syndrome	30.97	17.67	6	24068	36	79720278
Alopecia	30.33	17.67	16	24058	231339	79488975
Fatigue	29.96	17.67	419	23655	929308	78791006
Dry mouth	29.44	17.67	75	23999	87944	79632370
Injection site infection	29.27	17.67	14	24060	2198	79718116
Febrile bone marrow aplasia	28.97	17.67	27	24047	12993	79707321
Swelling face	28.46	17.67	65	24009	71147	79649167
Motor dysfunction	27.97	17.67	28	24046	14705	79705609
Interstitial lung disease	27.87	17.67	86	23988	112514	79607800
Constipation	27.84	17.67	163	23911	282887	79437427
Lung disorder	27.32	17.67	69	24005	80488	79639826
Meningitis tuberculous	26.87	17.67	11	24063	1194	79719120
Angina pectoris	26.19	17.67	52	24022	51680	79668634
Product use issue	26.18	17.67	129	23945	209693	79510621
C-reactive protein increased	26.08	17.67	92	23982	128935	79591379
Paraplegia	25.52	17.67	17	24057	5036	79715278
Insomnia	25.38	17.67	22	24052	245148	79475166
Cardiac failure congestive	25.20	17.67	6	24068	142396	79577918
Alanine aminotransferase abnormal	24.94	17.67	21	24053	8846	79711468
Platelet count decreased	24.73	17.67	14	24060	194650	79525664
Systemic lupus erythematosus	23.74	17.67	4	24070	121145	79599169
Dyspnoea	23.52	17.67	157	23917	856868	78863446
Malaise	23.30	17.67	238	23836	489631	79230683
Chorioretinopathy	23.24	17.67	12	24062	2219	79718095
Skin haemorrhage	23.17	17.67	23	24051	11958	79708356
Carpal tunnel syndrome	23.11	17.67	29	24045	19499	79700815
Disability	22.82	17.67	27	24047	17093	79703221
Therapeutic product effect decreased	22.81	17.67	104	23970	163759	79556555
Diverticulum oesophageal	22.80	17.67	6	24068	159	79720155
Affect lability	22.49	17.67	22	24052	11237	79709077
Wound	22.41	17.67	4	24070	116175	79604139
Hemiplegia	22.33	17.67	25	24049	14914	79705400
Sacroiliitis	22.33	17.67	14	24060	3740	79716574
Renal impairment	22.05	17.67	10	24064	157773	79562541
Off label use	22.01	17.67	390	23684	906825	78813489
Hyperkalaemia	21.93	17.67	4	24070	114394	79605920
Anaphylactic reaction	21.70	17.67	65	24009	83678	79636636
Myocardial oedema	21.63	17.67	7	24067	388	79719926
Blood creatinine increased	21.40	17.67	10	24064	155047	79565267
Cardiac failure	21.35	17.67	10	24064	154832	79565482
Conjunctival ulcer	21.33	17.67	5	24069	81	79720233
Crystal arthropathy	21.23	17.67	6	24068	209	79720105
Glossodynia	21.19	17.67	3	24071	103334	79616980
Benign neoplasm	21.17	17.67	9	24065	1074	79719240
Mandibular mass	21.04	17.67	6	24068	216	79720098
Stomatitis	20.99	17.67	9	24065	146748	79573566
Oedema peripheral	20.19	17.67	28	24046	252260	79468054
Pemphigus	20.16	17.67	3	24071	99579	79620735
Feeling abnormal	19.94	17.67	98	23976	159101	79561213
Sneezing	19.82	17.67	27	24047	19656	79700658
Dental caries	19.80	17.67	21	24053	11799	79708515
Gastrointestinal haemorrhage	19.67	17.67	10	24064	147709	79572605
Renal failure	19.65	17.67	19	24055	200949	79519365
Thalassaemia minor	19.64	17.67	4	24070	32	79720282
Injection site joint infection	19.54	17.67	4	24070	33	79720281
Illness	19.18	17.67	43	24031	46468	79673846
Adjustment disorder	19.10	17.67	13	24061	3987	79716327
Product contamination microbial	18.95	17.67	8	24066	938	79719376
Rhabdomyolysis	18.94	17.67	4	24070	103127	79617187
Abdominal pain upper	18.77	17.67	24	24050	223795	79496519
Hypoglycaemia	18.54	17.67	4	24070	101590	79618724
Hyponatraemia	18.35	17.67	16	24058	177832	79542482
Mycobacterium kansasii infection	18.14	17.67	6	24068	356	79719958
Blood pressure abnormal	17.97	17.67	24	24050	17145	79703169
Thrombosis	17.89	17.67	61	24013	84039	79636275
Joint space narrowing	17.83	17.67	7	24067	681	79719633
Electrocardiogram QT prolonged	17.68	17.67	3	24071	90383	79629931

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
FDA MoA	N0000175450	Corticosteroid Hormone Receptor Agonists
FDA EPC	N0000175576	Corticosteroid
MeSH PA	D000893	Anti-Inflammatory Agents
MeSH PA	D000932	Antiemetics
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D005765	Gastrointestinal Agents
MeSH PA	D005938	Glucocorticoids
MeSH PA	D006728	Hormones
MeSH PA	D018696	Neuroprotective Agents
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D020011	Protective Agents
CHEBI has role	CHEBI:35472	anti-inflammatory drugs
CHEBI has role	CHEBI:35703	Xenobiotic
CHEBI has role	CHEBI:37962	adrenergic agents
CHEBI has role	CHEBI:50919	antiemetico
CHEBI has role	CHEBI:63726	neuroprotective agents
CHEBI has role	CHEBI:78298	environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Atopic dermatitis	indication	24079001	DOID:3310
Erythema multiforme	indication	36715001
Contact dermatitis	indication	40275004	DOID:2773
Humoral hypercalcemia of malignancy	indication	47709007
Pemphigus	indication	65172003	DOID:9182
Transfusion reaction due to serum protein reaction	indication	72284000
Dermatitis herpetiformis	indication	111196000	DOID:8505
Mycosis fungoides	indication	118618005
Congenital adrenal hyperplasia	indication	237751000
Seasonal allergic rhinitis	indication	367498001
Adrenal cortical hypofunction	indication	386584007	DOID:10493
Perennial allergic rhinitis	indication	446096008
Transfusion Reaction Urticaria	indication
Exfoliative Erythroderma	indication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

Product	Applicant	Ingredients
Depo-Medrol	Zoetis Inc.	1
Methylprednisolone Acetate Inj.	Cronus Pharma Specialities India Private Limited	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	12.63	acidic
pKa2	13.35	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN	AGONIST				DRUG LABEL	DRUG LABEL

External reference:

ID	Source
4018070	VUID
N0000179565	NUI
D00979	KEGG_DRUG
4018068	VANDF
4018070	VANDF
C0600901	UMLSCUI
CHEBI:6889	CHEBI
CHEBI:6888	CHEBI
CHEMBL1200844	ChEMBL_ID
CHEMBL1364144	ChEMBL_ID
D000077555	MESH_DESCRIPTOR_UI
5877	PUBCHEM_CID
43502P7F0P	UNII
DB00959	DRUGBANK_ID
155323	RXNORM
1041	MMSL
4853	MMSL
5093	MMSL
5094	MMSL
d00293	MMSL
002160	NDDF
002161	NDDF
116593003	SNOMEDCT_US
27242001	SNOMEDCT_US
80959009	SNOMEDCT_US
C0025815	UMLSCUI
732	INN_ID
6741	PUBCHEM_CID
D008775	MESH_DESCRIPTOR_UI

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Depo-Medrol	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0274	INJECTION, SUSPENSION	20 mg	INTRAMUSCULAR	NDA	22 sections
Depo-Medrol	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0280	INJECTION, SUSPENSION	40 mg	INTRAMUSCULAR	NDA	22 sections
Depo-Medrol	HUMAN PRESCRIPTION DRUG LABEL	1	0009-0306	INJECTION, SUSPENSION	80 mg	INTRAMUSCULAR	NDA	22 sections
Depo-Medrol	HUMAN PRESCRIPTION DRUG LABEL	1	0009-3073	INJECTION, SUSPENSION	40 mg	INTRAMUSCULAR	NDA	22 sections
Depo-Medrol	HUMAN PRESCRIPTION DRUG LABEL	1	0009-3073	INJECTION, SUSPENSION	40 mg	INTRAMUSCULAR	NDA	22 sections
Depo-Medrol	HUMAN PRESCRIPTION DRUG LABEL	1	0009-3073	INJECTION, SUSPENSION	40 mg	INTRAMUSCULAR	NDA	22 sections
Depo-Medrol	HUMAN PRESCRIPTION DRUG LABEL	1	0009-3475	INJECTION, SUSPENSION	80 mg	INTRAMUSCULAR	NDA	22 sections
Depo-Medrol	HUMAN PRESCRIPTION DRUG LABEL	1	0009-3475	INJECTION, SUSPENSION	80 mg	INTRAMUSCULAR	NDA	22 sections
Depo-Medrol	HUMAN PRESCRIPTION DRUG LABEL	1	0009-3475	INJECTION, SUSPENSION	80 mg	INTRAMUSCULAR	NDA	22 sections
Methylprednisolone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	0703-0031	INJECTION, SUSPENSION	40 mg	INTRA-ARTICULAR	ANDA	12 sections
Methylprednisolone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	0703-0043	INJECTION, SUSPENSION	40 mg	INTRALESIONAL	ANDA	20 sections
Methylprednisolone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	0703-0045	INJECTION, SUSPENSION	40 mg	INTRALESIONAL	ANDA	20 sections
Methylprednisolone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	0703-0051	INJECTION, SUSPENSION	80 mg	INTRA-ARTICULAR	ANDA	12 sections
Methylprednisolone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	0703-0063	INJECTION, SUSPENSION	80 mg	INTRALESIONAL	ANDA	20 sections
METHYLPREDNISOLONE ACETATE	Human Prescription Drug Label	1	0781-3516	INJECTION, SUSPENSION	80 mg	INTRAMUSCULAR	ANDA	20 sections
Methylprednisolone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	16714-088	INJECTION, SUSPENSION	40 mg	INTRA-ARTICULAR	ANDA	12 sections
Methylprednisolone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	16714-089	INJECTION, SUSPENSION	40 mg	INTRALESIONAL	ANDA	20 sections
Methylprednisolone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	16714-090	INJECTION, SUSPENSION	40 mg	INTRALESIONAL	ANDA	20 sections
Methylprednisolone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	16714-472	INJECTION, SUSPENSION	80 mg	INTRA-ARTICULAR	ANDA	12 sections
Methylprednisolone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	16714-473	INJECTION, SUSPENSION	80 mg	INTRALESIONAL	ANDA	20 sections
Methylprednisolone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	21695-849	INJECTION, SUSPENSION	40 mg	INTRA-ARTICULAR	ANDA	17 sections
Methylprednisolone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	21695-850	INJECTION, SUSPENSION	80 mg	INTRA-ARTICULAR	ANDA	17 sections
Depo-Medrol	HUMAN PRESCRIPTION DRUG LABEL	1	21695-952	INJECTION, SUSPENSION	40 mg	INTRAMUSCULAR	NDA	22 sections
methylprednisolone acetate	HUMAN PRESCRIPTION DRUG LABEL	1	25021-820	INJECTION, SUSPENSION	40 mg	INTRA-ARTICULAR	ANDA	21 sections
methylprednisolone acetate	HUMAN PRESCRIPTION DRUG LABEL	1	25021-821	INJECTION, SUSPENSION	80 mg	INTRA-ARTICULAR	ANDA	21 sections
METHYLPREDNISOLONE ACETATE	HUMAN PRESCRIPTION DRUG LABEL	1	42023-239	INJECTION, SUSPENSION	40 mg	INTRA-ARTICULAR	ANDA	18 sections
Methylprednisolone Acetate	HUMAN PRESCRIPTION DRUG LABEL	1	42023-240	INJECTION, SUSPENSION	80 mg	INTRA-ARTERIAL	ANDA	18 sections
Depo-Medrol	HUMAN PRESCRIPTION DRUG LABEL	1	50090-0312	INJECTION, SUSPENSION	40 mg	INTRAMUSCULAR	NDA	21 sections
Depo-Medrol	HUMAN PRESCRIPTION DRUG LABEL	1	50090-0312	INJECTION, SUSPENSION	40 mg	INTRAMUSCULAR	NDA	21 sections
Depo-Medrol	HUMAN PRESCRIPTION DRUG LABEL	1	50090-0436	INJECTION, SUSPENSION	80 mg	INTRAMUSCULAR	NDA	21 sections