amiodarone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antiarrhythmics 176 1951-25-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • amiodarone
  • amidorone
  • sedacoron
  • amiodarone hydrochloride
  • amiodarone HCl
An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
  • Molecular weight: 645.32
  • Formula: C25H29I2NO3
  • CLOGP: 8.95
  • LIPINSKI: 2
  • HAC: 4
  • HDO: 0
  • TPSA: 42.68
  • ALOGS: -5.13
  • ROTB: 11
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.20 g O
0.20 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.72 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 41.37 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 60 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.90 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.00 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 820 hours Lombardo F, Berellini G, Obach RS
BA (Bioavailability) 0.50 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

DateAgencyCompanyOrphan
Dec. 24, 1985 FDA WYETH PHARMS INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug interaction 1228.21 12.53 1241 54489 227890 63205402
Bradycardia 840.93 12.53 615 55115 72612 63360680
Torsade de pointes 838.00 12.53 346 55384 13005 63420287
Electrocardiogram QT prolonged 752.19 12.53 530 55200 59000 63374292
Atrial fibrillation 701.50 12.53 674 55056 115962 63317330
Hyperthyroidism 683.39 12.53 308 55422 14365 63418927
Acute kidney injury 470.41 12.53 834 54896 262581 63170711
Interstitial lung disease 398.83 12.53 372 55358 61536 63371756
International normalised ratio increased 393.37 12.53 326 55404 46099 63387193
Myxoedema coma 364.12 12.53 83 55647 352 63432940
Pulmonary toxicity 351.87 12.53 170 55560 9285 63424007
Cardiac failure 348.31 12.53 410 55320 88732 63344560
Ventricular tachycardia 329.25 12.53 210 55520 19769 63413523
Sinus bradycardia 283.04 12.53 170 55560 14381 63418911
Hypothyroidism 262.63 12.53 250 55480 42382 63390910
Hyperkalaemia 241.55 12.53 267 55463 53936 63379356
Cardiogenic shock 236.29 12.53 164 55566 17768 63415524
Hyponatraemia 231.69 12.53 379 55351 111521 63321771
Syncope 222.28 12.53 382 55348 117003 63316289
Pain 213.82 12.53 202 55528 740426 62692866
Hypotension 212.79 12.53 622 55108 271982 63161310
Haematoma 210.29 12.53 202 55528 34618 63398674
Gastrointestinal haemorrhage 208.77 12.53 304 55426 80872 63352420
Ventricular fibrillation 201.14 12.53 127 55603 11740 63421552
Cardiac arrest 185.52 12.53 309 55421 92236 63341056
Joint swelling 173.27 12.53 38 55692 327628 63105664
Arthralgia 169.36 12.53 151 55579 569559 62863733
Renal failure 166.52 12.53 338 55392 117314 63315978
Tachyarrhythmia 165.52 12.53 80 55650 4370 63428922
Thyroiditis 154.94 12.53 64 55666 2402 63430890
Shock haemorrhagic 153.11 12.53 100 55630 9795 63423497
Cardiac failure congestive 147.08 12.53 279 55451 92154 63341138
Headache 146.48 12.53 206 55524 633035 62800257
Glossodynia 142.36 12.53 3 55727 178873 63254419
Arthropathy 142.12 12.53 19 55711 234773 63198519
Synovitis 141.85 12.53 5 55725 186913 63246379
Alopecia 139.38 12.53 61 55669 337475 63095817
Therapeutic product effect decreased 137.38 12.53 8 55722 193179 63240113
Sinus node dysfunction 135.41 12.53 71 55659 4614 63428678
Rash 135.16 12.53 177 55553 560694 62872598
Systemic lupus erythematosus 133.63 12.53 14 55716 208904 63224388
Drug intolerance 133.54 12.53 52 55678 308609 63124683
Infusion related reaction 132.75 12.53 27 55703 245494 63187798
Hypokalaemia 129.17 12.53 283 55447 103521 63329771
Rheumatoid arthritis 129.03 12.53 32 55698 253787 63179505
Sinusitis 120.31 12.53 26 55704 226627 63206665
Swelling 113.27 12.53 50 55680 275328 63157964
Atrial flutter 111.75 12.53 82 55648 9690 63423602
Lactic acidosis 106.62 12.53 149 55581 38138 63395154
Anaemia 104.93 12.53 522 55208 292908 63140384
Cerebral haemorrhage 104.68 12.53 132 55598 30597 63402695
Wound 101.70 12.53 12 55718 163251 63270041
Hypersensitivity 101.54 12.53 66 55664 292619 63140673
Multiple organ dysfunction syndrome 101.20 12.53 180 55550 56572 63376720
Melaena 101.16 12.53 129 55601 30236 63403056
Mitral valve incompetence 98.62 12.53 103 55627 19491 63413801
Long QT syndrome 98.51 12.53 51 55679 3228 63430064
Musculoskeletal stiffness 94.32 12.53 23 55707 184595 63248697
Arrhythmia 93.88 12.53 140 55590 38000 63395292
Alveolitis 92.38 12.53 47 55683 2868 63430424
Abdominal discomfort 91.63 12.53 88 55642 320797 63112495
Fall 89.61 12.53 620 55110 391714 63041578
Labelled drug-drug interaction medication error 89.04 12.53 82 55648 13317 63419975
Nasopharyngitis 88.63 12.53 57 55673 254200 63179092
Fatigue 87.20 12.53 443 55287 887585 62545707
Drug ineffective 87.11 12.53 550 55180 1044215 62389077
Atrioventricular block 87.06 12.53 64 55666 7583 63425709
Hypoxia 85.96 12.53 173 55557 59619 63373673
Ventricular extrasystoles 84.50 12.53 75 55655 11612 63421680
Rhabdomyolysis 83.03 12.53 143 55587 43808 63389484
Cardio-respiratory arrest 82.08 12.53 170 55560 59789 63373503
Cholestasis 81.13 12.53 114 55616 29320 63403972
Ventricular arrhythmia 80.37 12.53 47 55683 3781 63429511
Pericarditis 78.73 12.53 11 55719 131568 63301724
Hypersensitivity myocarditis 78.05 12.53 21 55709 195 63433097
Respiratory failure 77.85 12.53 231 55499 101627 63331665
Cerebral haematoma 76.75 12.53 45 55685 3638 63429654
Infection 71.22 12.53 58 55672 229115 63204177
Maternal exposure during pregnancy 70.52 12.53 54 55676 220008 63213284
Pulmonary hypertension 70.40 12.53 121 55609 37002 63396290
Cardioversion 70.13 12.53 30 55700 1230 63432062
Product use issue 69.54 12.53 55 55675 220465 63212827
Atrioventricular block complete 67.86 12.53 57 55673 8194 63425098
Renal injury 65.13 12.53 59 55671 9380 63423912
Pain in extremity 64.95 12.53 120 55610 331366 63101926
Injection site pain 64.68 12.53 17 55713 129783 63303509
Toxicity to various agents 63.14 12.53 402 55328 246848 63186444
Haematoma muscle 63.04 12.53 27 55703 1110 63432182
Haemorrhage 62.29 12.53 154 55576 60868 63372424
Neuromyopathy 61.62 12.53 23 55707 656 63432636
Psoriatic arthropathy 61.50 12.53 5 55725 91515 63341777
Arterial haemorrhage 61.24 12.53 30 55700 1687 63431605
Hypoaesthesia 61.08 12.53 36 55694 168357 63264935
Blood cholesterol increased 60.86 12.53 6 55724 94026 63339266
Discomfort 60.40 12.53 36 55694 167338 63265954
Coronary artery disease 59.39 12.53 104 55626 32273 63401019
Contraindicated product administered 58.31 12.53 63 55667 217585 63215707
Hepatocellular injury 58.28 12.53 94 55636 27287 63406005
Fibromyalgia 58.16 12.53 3 55727 80417 63352875
Brugada syndrome 57.75 12.53 19 55711 369 63432923
Blood thyroid stimulating hormone increased 57.73 12.53 49 55681 7145 63426147
Blood loss anaemia 57.71 12.53 54 55676 8947 63424345
Stomatitis 57.27 12.53 25 55705 138700 63294592
Migraine 56.57 12.53 11 55719 103335 63329957
Treatment failure 56.28 12.53 55 55675 198988 63234304
Therapeutic product effect incomplete 55.79 12.53 20 55710 125036 63308256
Rectal haemorrhage 55.71 12.53 129 55601 48901 63384391
Orthopnoea 55.13 12.53 45 55685 6216 63427076
Lymphatic fistula 54.86 12.53 22 55708 764 63432528
Infusion site phlebitis 54.63 12.53 13 55717 69 63433223
Femoral hernia incarcerated 53.42 12.53 22 55708 819 63432473
Acute respiratory distress syndrome 53.12 12.53 83 55647 23451 63409841
Urticaria 52.70 12.53 41 55689 165761 63267531
Arthritis 52.64 12.53 18 55712 115903 63317389
Mixed liver injury 52.49 12.53 39 55691 4696 63428596
Drug level increased 52.46 12.53 81 55649 22655 63410637
Weight increased 52.32 12.53 93 55637 260699 63172593
Muscle spasms 51.70 12.53 37 55693 156113 63277179
Ischaemic stroke 51.65 12.53 71 55659 17886 63415406
Faecaloma 51.60 12.53 48 55682 7893 63425399
Cardioactive drug level increased 51.50 12.53 29 55701 2171 63431121
Sudden death 50.92 12.53 54 55676 10395 63422897
Left ventricular dysfunction 49.84 12.53 57 55673 11931 63421361
Respiratory distress 49.70 12.53 99 55631 33852 63399440
Atrial tachycardia 49.43 12.53 36 55694 4204 63429088
Pancreatic steatosis 49.42 12.53 22 55708 994 63432298
Haemarthrosis 49.03 12.53 32 55698 3129 63430163
Hyperglobulinaemia 48.31 12.53 8 55722 0 63433292
Toxic skin eruption 48.14 12.53 58 55672 12827 63420465
Myocardial infarction 47.84 12.53 194 55536 99699 63333593
Urinary retention 47.57 12.53 91 55639 30210 63403082
Haematuria 47.55 12.53 89 55641 29068 63404224
Product dose omission issue 47.49 12.53 83 55647 234230 63199062
Acute respiratory failure 47.44 12.53 98 55632 34387 63398905
Cardiac ablation 47.22 12.53 24 55706 1461 63431831
Bradyarrhythmia 47.15 12.53 27 55703 2088 63431204
Wound infection pseudomonas 46.76 12.53 23 55707 1305 63431987
Dyspnoea 46.74 12.53 827 54903 660486 62772806
Nodal rhythm 46.38 12.53 25 55705 1718 63431574
Exposure during pregnancy 46.30 12.53 41 55689 155506 63277786
Back pain 46.26 12.53 102 55628 264043 63169249
Ill-defined disorder 46.25 12.53 8 55722 81747 63351545
Coagulopathy 45.74 12.53 72 55658 20472 63412820
Lung disorder 45.47 12.53 139 55591 62122 63371170
Injection site erythema 45.21 12.53 9 55721 83165 63350127
Septic shock 45.21 12.53 145 55585 66484 63366808
Pneumonitis 43.73 12.53 96 55634 35126 63398166
Pyrexia 42.99 12.53 240 55490 470238 62963054
Thyrotoxic crisis 42.71 12.53 19 55711 857 63432435
Pruritus 42.66 12.53 168 55562 361285 63072007
Irritable bowel syndrome 42.59 12.53 10 55720 82402 63350890
Tricuspid valve incompetence 42.34 12.53 58 55672 14563 63418729
Pulmonary fibrosis 42.25 12.53 102 55628 39707 63393585
Keratopathy 42.16 12.53 17 55713 599 63432693
Listless 42.05 12.53 28 55702 2832 63430460
Corneal deposits 41.98 12.53 14 55716 284 63433008
Diarrhoea 41.89 12.53 414 55316 714952 62718340
Acute hepatic failure 41.87 12.53 65 55665 18262 63415030
Ecchymosis 41.55 12.53 50 55680 11044 63422248
Cerebellar syndrome 41.14 12.53 30 55700 3509 63429783
Bundle branch block left 40.80 12.53 40 55690 7019 63426273
Off label use 40.03 12.53 389 55341 674073 62759219
Peripheral swelling 39.32 12.53 112 55618 265830 63167462
Spontaneous haematoma 39.20 12.53 18 55712 875 63432417
Hepatic cyst 39.11 12.53 34 55696 5120 63428172
Subdural haematoma 38.74 12.53 55 55675 14273 63419019
Hypoglycaemia 38.31 12.53 128 55602 59937 63373355
Reduced facial expression 38.30 12.53 23 55707 1943 63431349
Anuria 38.18 12.53 51 55679 12500 63420792
Cerebellar haematoma 38.12 12.53 14 55716 381 63432911
Overdose 37.71 12.53 200 55530 114878 63318414
Pleural effusion 37.69 12.53 172 55558 93038 63340254
Depression 37.67 12.53 72 55658 196420 63236872
Respiratory acidosis 36.87 12.53 37 55693 6678 63426614
Extravasation 36.76 12.53 24 55706 2348 63430944
Seroma 36.59 12.53 23 55707 2108 63431184
Intentional product use issue 36.52 12.53 35 55695 127857 63305435
Myalgia 36.43 12.53 45 55685 146484 63286808
Heparin-induced thrombocytopenia 36.34 12.53 31 55699 4551 63428741
Device stimulation issue 36.20 12.53 9 55721 59 63433233
Hepatic enzyme increased 35.51 12.53 78 55652 202250 63231042
Alveolar proteinosis 35.46 12.53 13 55717 352 63432940
Psoriasis 35.36 12.53 16 55714 86941 63346351
Hypomagnesaemia 35.30 12.53 78 55652 28659 63404633
Extrasystoles 35.10 12.53 32 55698 5128 63428164
Drug-induced liver injury 34.37 12.53 95 55635 40127 63393165
Hepatic failure 34.30 12.53 88 55642 35568 63397724
Acute pulmonary oedema 34.27 12.53 39 55691 8119 63425173
Oliguria 34.06 12.53 41 55689 9060 63424232
Asthma 34.05 12.53 37 55693 127524 63305768
Hepatitis acute 33.99 12.53 41 55689 9079 63424213
Aortic valve stenosis 33.97 12.53 26 55704 3273 63430019
Gastrooesophageal reflux disease 33.89 12.53 21 55709 95618 63337674
Pulmonary alveolar haemorrhage 33.83 12.53 30 55700 4638 63428654
Cornea verticillata 33.17 12.53 10 55720 144 63433148
Prothrombin time shortened 32.92 12.53 21 55709 1974 63431318
Craniocerebral injury 32.91 12.53 24 55706 2808 63430484
Inflammatory marker increased 32.72 12.53 35 55695 6804 63426488
Nausea 32.69 12.53 541 55189 853930 62579362
Muscle haemorrhage 32.61 12.53 25 55705 3154 63430138
Right ventricular failure 32.55 12.53 56 55674 17132 63416160
Head injury 32.13 12.53 73 55657 27323 63405969
Renal impairment 32.05 12.53 158 55572 88197 63345095
Organising pneumonia 32.03 12.53 32 55698 5744 63427548
Myxoedema 31.99 12.53 9 55721 100 63433192
Haemorrhagic stroke 31.96 12.53 32 55698 5760 63427532
Encephalopathy 31.80 12.53 90 55640 38530 63394762
Agranulocytosis 31.76 12.53 69 55661 25065 63408227
Pericardial haemorrhage 31.69 12.53 19 55711 1600 63431692
Insomnia 31.55 12.53 91 55639 215161 63218131
Knee arthroplasty 31.33 12.53 5 55725 54201 63379091
Abdominal wall haematoma 31.29 12.53 24 55706 3031 63430261
Cardiac disorder 31.26 12.53 107 55623 50709 63382583
Cardiac failure chronic 31.24 12.53 28 55702 4390 63428902
Glomerular filtration rate decreased 31.17 12.53 48 55682 13393 63419899
Arrhythmia supraventricular 31.10 12.53 16 55714 999 63432293
Type 2 diabetes mellitus 30.62 12.53 9 55721 63859 63369433
Acute generalised exanthematous pustulosis 30.59 12.53 43 55687 11056 63422236
Lower gastrointestinal haemorrhage 30.27 12.53 36 55694 7854 63425438
Oedema peripheral 30.20 12.53 276 55454 189235 63244057
Iodine overload 30.20 12.53 5 55725 0 63433292
Anticoagulation drug level increased 30.03 12.53 10 55720 202 63433090
Abdominal pain upper 29.73 12.53 88 55642 206356 63226936
White blood cell count decreased 29.34 12.53 48 55682 139056 63294236
Hypervolaemia 29.29 12.53 72 55658 28341 63404951
Haemorrhagic diathesis 29.29 12.53 27 55703 4388 63428904
Atrioventricular block first degree 29.26 12.53 34 55696 7239 63426053
Shock 29.18 12.53 64 55666 23399 63409893
Ventricular tachyarrhythmia 29.10 12.53 9 55721 142 63433150
Blister 29.09 12.53 43 55687 129771 63303521
Mediastinal haematoma 28.76 12.53 8 55722 85 63433207
Pericardial effusion 28.72 12.53 74 55656 29984 63403308
Drug hypersensitivity 28.59 12.53 158 55572 310529 63122763
Injection site reaction 28.51 12.53 8 55722 58516 63374776
Suicide attempt 28.45 12.53 9 55721 60909 63372383
Abortion spontaneous 28.09 12.53 4 55726 47191 63386101
Retroperitoneal haematoma 27.91 12.53 22 55708 2891 63430401
Cardiac arrest neonatal 27.80 12.53 8 55722 97 63433195
Blood creatinine increased 27.64 12.53 151 55579 87693 63345599
Rales 27.58 12.53 44 55686 12653 63420639
Goitre congenital 27.26 12.53 5 55725 4 63433288
Herpes zoster 26.68 12.53 20 55710 82442 63350850
Retroperitoneal haemorrhage 26.53 12.53 21 55709 2776 63430516
Diverticulum intestinal 26.37 12.53 31 55699 6682 63426610
Subarachnoid haemorrhage 26.34 12.53 46 55684 14237 63419055
Hepatic cytolysis 26.34 12.53 48 55682 15359 63417933
Nodal arrhythmia 26.33 12.53 15 55715 1148 63432144
Paraesthesia 26.33 12.53 62 55668 156904 63276388
Lower respiratory tract infection 25.77 12.53 48 55682 132259 63301033
Transaminases increased 25.73 12.53 73 55657 31294 63401998
Subcutaneous haematoma 25.69 12.53 17 55713 1701 63431591
Ejection fraction decreased 25.63 12.53 59 55671 22273 63411019
Oesophageal squamous cell carcinoma 25.42 12.53 8 55722 134 63433158
Asthenia 25.32 12.53 475 55255 383129 63050163
Coronary artery bypass 25.12 12.53 19 55711 2350 63430942
Thrombocytopenia 25.02 12.53 222 55508 150935 63282357
C-reactive protein abnormal 25.02 12.53 5 55725 46091 63387201
Central nervous system injury 24.94 12.53 8 55722 143 63433149
Cardiac failure acute 24.93 12.53 36 55694 9487 63423805
Lung consolidation 24.90 12.53 24 55706 4124 63429168
Myopathy 24.60 12.53 39 55691 11152 63422140
Medication error 24.59 12.53 101 55629 52183 63381109
Device capturing issue 24.45 12.53 6 55724 37 63433255
Sinoatrial block 24.36 12.53 13 55717 875 63432417
Electrocardiogram QRS complex prolonged 24.29 12.53 28 55702 5910 63427382
General physical health deterioration 24.27 12.53 277 55453 201125 63232167
Liver function test abnormal 24.20 12.53 95 55635 48086 63385206
Injection site bruising 23.92 12.53 4 55726 41906 63391386
Cardiac tamponade 23.84 12.53 25 55705 4750 63428542
Eosinophilia 23.81 12.53 58 55672 22698 63410594
Constipation 23.76 12.53 109 55621 224834 63208458
Adverse event 23.70 12.53 15 55715 67544 63365748
Aortic arteriosclerosis 23.28 12.53 28 55702 6181 63427111
Hypocoagulable state 23.20 12.53 14 55716 1193 63432099
Foreign body 23.14 12.53 18 55712 2320 63430972
Presyncope 23.12 12.53 65 55665 27720 63405572
Feeling abnormal 23.02 12.53 61 55669 148331 63284961
Death 22.81 12.53 458 55272 373923 63059369
Upper respiratory tract infection 22.79 12.53 23 55707 82024 63351268
Hepatitis fulminant 22.63 12.53 21 55709 3443 63429849
Intra-abdominal haematoma 22.58 12.53 16 55714 1789 63431503
Thyroxine increased 22.46 12.53 11 55719 618 63432674
Hypoxic-ischaemic encephalopathy 22.40 12.53 23 55707 4264 63429028
Splenic haemorrhage 22.31 12.53 8 55722 203 63433089
Musculoskeletal pain 22.24 12.53 29 55701 92248 63341044
Neck pain 22.19 12.53 17 55713 69301 63363991
Potentiating drug interaction 22.10 12.53 23 55707 4333 63428959
Splenic injury 21.99 12.53 8 55722 212 63433080
Pulmonary oedema 21.98 12.53 101 55629 54772 63378520
Osteoarthritis 21.93 12.53 31 55699 95312 63337980
Haemorrhage intracranial 21.92 12.53 41 55689 13378 63419914
Mitral valve disease mixed 21.92 12.53 4 55726 3 63433289
Influenza like illness 21.89 12.53 16 55714 66808 63366484
Hypochromasia 21.66 12.53 9 55721 343 63432949
Neovascular age-related macular degeneration 21.54 12.53 8 55722 225 63433067
Red blood cell sedimentation rate increased 21.45 12.53 6 55724 43976 63389316
Night sweats 21.43 12.53 8 55722 48806 63384486
Inappropriate antidiuretic hormone secretion 21.33 12.53 44 55686 15418 63417874
Chills 21.32 12.53 42 55688 113336 63319956
Prerenal failure 21.14 12.53 15 55715 1681 63431611
Gastrointestinal disorder 21.09 12.53 53 55677 131186 63302106
Ear infection 21.05 12.53 4 55726 38209 63395083
Cardioactive drug level above therapeutic 20.99 12.53 7 55723 142 63433150
Pelvic fracture 20.84 12.53 40 55690 13308 63419984
Cyanosis 20.84 12.53 46 55684 16889 63416403
Throat irritation 20.61 12.53 4 55726 37643 63395649
Prothrombin time prolonged 20.57 12.53 33 55697 9531 63423761
Injection site swelling 20.55 12.53 8 55722 47564 63385728
Oropharyngeal pain 20.49 12.53 32 55698 94455 63338837
Ischaemic hepatitis 20.31 12.53 16 55714 2100 63431192
Impaired healing 20.14 12.53 37 55693 102505 63330787
Tubulointerstitial nephritis 20.06 12.53 50 55680 19853 63413439
Pulmonary arterial hypertension 19.96 12.53 54 55676 22523 63410769
Anti-thyroid antibody positive 19.92 12.53 9 55721 421 63432871
Wound dehiscence 19.86 12.53 23 55707 4880 63428412
Propionibacterium infection 19.71 12.53 5 55725 36 63433256
Device pacing issue 19.62 12.53 6 55724 91 63433201
Dyschromatopsia 19.47 12.53 9 55721 444 63432848
Activated partial thromboplastin time prolonged 19.44 12.53 27 55703 6866 63426426
Myocardial ischaemia 19.42 12.53 38 55692 12821 63420471
Bone pain 19.35 12.53 12 55718 54629 63378663
Chronic kidney disease 19.26 12.53 85 55645 45313 63387979
Therapy non-responder 19.18 12.53 23 55707 75878 63357414
Thyroiditis acute 19.15 12.53 6 55724 99 63433193
Blood creatine increased 18.97 12.53 24 55706 5577 63427715
Thyroxine free increased 18.94 12.53 11 55719 873 63432419
Febrile neutropenia 18.90 12.53 48 55682 118401 63314891
Palpitations 18.85 12.53 166 55564 112604 63320688
Optic disc haemorrhage 18.82 12.53 6 55724 105 63433187
Local anaesthetic systemic toxicity 18.77 12.53 11 55719 888 63432404
Hypoglycaemic seizure 18.76 12.53 9 55721 483 63432809
Subdural haemorrhage 18.64 12.53 18 55712 3100 63430192
Prescription drug used without a prescription 18.63 12.53 16 55714 2370 63430922
Swelling face 18.55 12.53 17 55713 63458 63369834
Fear 18.47 12.53 42 55688 15724 63417568
Apathy 18.45 12.53 30 55700 8764 63424528
Memory impairment 18.44 12.53 40 55690 104218 63329074
Thyroglobulin increased 18.43 12.53 5 55725 48 63433244
Escherichia infection 18.43 12.53 37 55693 12717 63420575
Altered visual depth perception 18.41 12.53 8 55722 341 63432951
Conduction disorder 18.35 12.53 13 55717 1454 63431838
Head discomfort 18.30 12.53 38 55692 13377 63419915
Anisocytosis 18.27 12.53 10 55720 708 63432584
Electrocardiogram PR prolongation 18.20 12.53 10 55720 714 63432578
Tracheal compression 18.12 12.53 3 55727 0 63433292
Congenital hypothyroidism 17.97 12.53 7 55723 225 63433067
Cardiovascular disorder 17.95 12.53 35 55695 11777 63421515
Circulatory collapse 17.94 12.53 51 55679 21887 63411405
Pneumonitis chemical 17.85 12.53 7 55723 229 63433063
Goitre 17.79 12.53 24 55706 5937 63427355
Haemorrhagic thyroid cyst 17.73 12.53 4 55726 16 63433276
Dehydration 17.65 12.53 231 55499 173123 63260169
Congestive hepatopathy 17.62 12.53 17 55713 2925 63430367
Ear pain 17.48 12.53 5 55725 36113 63397179
Swollen joint count increased 17.43 12.53 5 55725 36049 63397243
Pharyngeal haematoma 17.42 12.53 5 55725 60 63433232
Petechiae 17.38 12.53 38 55692 13859 63419433
Ataxia 17.28 12.53 40 55690 15155 63418137
Anhedonia 17.27 12.53 33 55697 10941 63422351
Chorea 17.16 12.53 13 55717 1611 63431681
Electrocardiogram T wave inversion 16.98 12.53 18 55712 3463 63429829
Hypovolaemic shock 16.94 12.53 24 55706 6217 63427075
Drug level above therapeutic 16.93 12.53 21 55709 4784 63428508
Tri-iodothyronine increased 16.89 12.53 6 55724 148 63433144
Secondary hyperthyroidism 16.69 12.53 4 55726 22 63433270
Neutrophil count decreased 16.61 12.53 15 55715 56391 63376901
Haemoglobin decreased 16.58 12.53 198 55532 145287 63288005
Compensatory sweating 16.54 12.53 4 55726 23 63433269
Apnoea 16.33 12.53 27 55703 7995 63425297
Anticoagulation drug level above therapeutic 16.31 12.53 12 55718 1423 63431869
Dyspnoea at rest 16.29 12.53 19 55711 4060 63429232
Cardiovascular insufficiency 16.27 12.53 12 55718 1429 63431863
Kidney malrotation 16.25 12.53 4 55726 25 63433267
Pulseless electrical activity 16.25 12.53 26 55704 7495 63425797
Therapeutic response decreased 16.24 12.53 18 55712 61507 63371785
Coagulation time prolonged 16.21 12.53 12 55718 1436 63431856
Intentional overdose 16.18 12.53 25 55705 74127 63359165
Electrocardiogram QRS complex shortened 16.15 12.53 8 55722 461 63432831
Sedation 16.00 12.53 7 55723 38802 63394490
Drug clearance decreased 15.95 12.53 12 55718 1472 63431820
Loss of consciousness 15.84 12.53 166 55564 117955 63315337
Disease progression 15.79 12.53 55 55675 122703 63310589
Hepatitis 15.76 12.53 73 55657 39715 63393577
Gastroenteritis aeromonas 15.74 12.53 4 55726 29 63433263
Illness 15.74 12.53 12 55718 49047 63384245
Sopor 15.72 12.53 49 55681 22115 63411177
COVID-19 15.70 12.53 49 55681 113054 63320238
Infective pericardial effusion 15.62 12.53 4 55726 30 63433262
Eosinophilic pneumonia 15.61 12.53 14 55716 2197 63431095
Lip swelling 15.59 12.53 4 55726 31059 63402233
Endovenous ablation 15.58 12.53 3 55727 4 63433288
Lung infiltration 15.28 12.53 37 55693 14426 63418866
Electrocardiogram U wave present 15.25 12.53 5 55725 96 63433196
Atrioventricular block second degree 15.25 12.53 18 55712 3896 63429396
Optic atrophy 15.24 12.53 11 55719 1267 63432025
Mobility decreased 15.11 12.53 55 55675 121104 63312188
Hyperchloraemia 15.05 12.53 9 55721 754 63432538
Cerebrovascular accident 15.05 12.53 153 55577 107871 63325421
Cutaneous lupus erythematosus 14.99 12.53 15 55715 2697 63430595
Oesophageal adenocarcinoma recurrent 14.98 12.53 4 55726 36 63433256
Hypothyroidic goitre 14.83 12.53 3 55727 6 63433286
Splenic rupture 14.78 12.53 11 55719 1327 63431965
Bursitis 14.77 12.53 7 55723 37034 63396258
Ventricular asystole 14.74 12.53 5 55725 107 63433185
Anaphylactic reaction 14.70 12.53 22 55708 66078 63367214
Coagulation test abnormal 14.68 12.53 9 55721 789 63432503
Atrioventricular dissociation 14.66 12.53 6 55724 220 63433072
Optic neuropathy 14.61 12.53 13 55717 2019 63431273
Paroxysmal arrhythmia 14.60 12.53 4 55726 40 63433252
Adverse drug reaction 14.58 12.53 30 55700 79684 63353608
Hepatitis toxic 14.43 12.53 16 55714 3237 63430055
Electrocardiogram T wave alternans 14.42 12.53 4 55726 42 63433250
Electrocardiogram T wave abnormal 14.39 12.53 14 55716 2433 63430859
Extradural haematoma 14.37 12.53 12 55718 1710 63431582
Liver scan abnormal 14.34 12.53 4 55726 43 63433249
Oral mucosa haematoma 14.23 12.53 3 55727 8 63433284
Thyroid disorder 14.15 12.53 37 55693 15125 63418167
Feeling hot 14.11 12.53 14 55716 50340 63382952
Low cardiac output syndrome 13.96 12.53 7 55723 414 63432878
Cutaneous vasculitis 13.91 12.53 20 55710 5249 63428043
Eosinophilic pleural effusion 13.86 12.53 4 55726 49 63433243
Concomitant disease aggravated 13.85 12.53 27 55703 9085 63424207
Haemodynamic instability 13.69 12.53 27 55703 9163 63424129
Suicidal ideation 13.66 12.53 21 55709 62400 63370892
Dialysis 13.60 12.53 29 55701 10398 63422894
Eosinophilia myalgia syndrome 13.51 12.53 3 55727 11 63433281
Cardiomegaly 13.49 12.53 40 55690 17574 63415718
Photosensitivity reaction 13.39 12.53 36 55694 14958 63418334
Monoclonal gammopathy 13.37 12.53 8 55722 671 63432621
Jaundice 13.35 12.53 56 55674 29195 63404097
Aortic valve incompetence 13.35 12.53 21 55709 5967 63427325
Pancreatitis 13.34 12.53 14 55716 49041 63384251
Thyroiditis chronic 13.30 12.53 3 55727 12 63433280
Erythema 13.24 12.53 95 55635 175656 63257636
Respiratory alkalosis 13.23 12.53 14 55716 2687 63430605
Lymphocyte count decreased 13.21 12.53 5 55725 30252 63403040
Blood pressure decreased 13.17 12.53 100 55630 64922 63368370
Joint range of motion decreased 13.13 12.53 6 55724 32422 63400870
Cardiac output decreased 13.06 12.53 9 55721 963 63432329
Eructation 13.04 12.53 25 55705 8308 63424984
Supraventricular extrasystoles 12.98 12.53 18 55712 4571 63428721
Tachypnoea 12.97 12.53 39 55691 17263 63416029
Retinal vein thrombosis 12.96 12.53 7 55723 483 63432809
Abdominal wall haemorrhage 12.94 12.53 5 55725 157 63433135
Anticoagulation drug level below therapeutic 12.94 12.53 8 55722 712 63432580
Renal function test abnormal 12.93 12.53 16 55714 3637 63429655
Sciatica 12.92 12.53 7 55723 34317 63398975
Neoplasm progression 12.90 12.53 8 55722 36420 63396872
Groin pain 12.88 12.53 28 55702 10175 63423117
Dry mouth 12.85 12.53 31 55699 77832 63355460
Blood pressure fluctuation 12.84 12.53 13 55717 46304 63386988
Proctitis haemorrhagic 12.76 12.53 3 55727 15 63433277
Left ventricular failure 12.75 12.53 20 55710 5667 63427625
Electrocardiogram repolarisation abnormality 12.73 12.53 10 55720 1307 63431985
Nephrolithiasis 12.56 12.53 11 55719 41973 63391319
Ventricular enlargement 12.55 12.53 4 55726 70 63433222
Mesenteric artery stenosis 12.55 12.53 4 55726 70 63433222
Hypertensive heart disease 12.53 12.53 13 55717 2439 63430853

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperthyroidism 1996.08 11.67 792 79529 9774 34866836
Pulmonary toxicity 690.13 11.67 319 80002 5828 34870782
Drug interaction 563.92 11.67 1450 78871 224496 34652114
Interstitial lung disease 537.96 11.67 705 79616 64577 34812033
Ventricular tachycardia 526.85 11.67 458 79863 26121 34850489
Bradycardia 524.20 11.67 750 79571 74668 34801942
Cardiac failure 491.24 11.67 806 79515 90442 34786168
Thyroiditis 380.22 11.67 158 80163 2204 34874406
Electrocardiogram QT prolonged 369.70 11.67 463 79858 40489 34836121
Atrial fibrillation 349.22 11.67 828 79493 121565 34755045
Hypothyroidism 346.84 11.67 326 79995 20576 34856034
Torsade de pointes 335.09 11.67 208 80113 7001 34869609
Cardiogenic shock 311.80 11.67 344 79977 26274 34850336
Thyrotoxic crisis 297.67 11.67 85 80236 330 34876280
Pulmonary fibrosis 267.72 11.67 267 80054 18129 34858481
Ventricular fibrillation 235.49 11.67 277 80044 22677 34853933
International normalised ratio increased 191.01 11.67 369 79952 46958 34829652
Ejection fraction decreased 184.71 11.67 224 80097 18930 34857680
Cardiac failure congestive 182.96 11.67 511 79810 82759 34793851
Acute kidney injury 181.96 11.67 1260 79061 303728 34572882
Appendicolith 171.87 11.67 149 80172 8452 34868158
Hypotension 170.15 11.67 977 79344 220672 34655938
Multiple organ dysfunction syndrome 165.37 11.67 467 79854 76099 34800511
Pulmonary alveolar haemorrhage 155.92 11.67 133 80188 7379 34869231
Pyrexia 131.75 11.67 364 79957 332649 34543961
Ventricular arrhythmia 131.66 11.67 106 80215 5422 34871188
Completed suicide 127.46 11.67 34 80287 98134 34778476
Appendicitis 126.50 11.67 163 80158 14644 34861966
Atrial flutter 126.15 11.67 167 80154 15407 34861203
Myxoedema coma 120.39 11.67 39 80282 251 34876359
Cardiac failure chronic 113.93 11.67 114 80207 7765 34868845
Lung disorder 109.96 11.67 245 80076 34451 34842159
Sinus bradycardia 109.64 11.67 142 80179 12821 34863789
Acute respiratory distress syndrome 106.58 11.67 204 80117 25765 34850845
Atrioventricular block 106.31 11.67 111 80210 7952 34868658
Arthralgia 104.36 11.67 143 80178 169898 34706712
Syncope 103.18 11.67 450 79871 91001 34785609
Blood thyroid stimulating hormone increased 102.20 11.67 82 80239 4173 34872437
Cardiac arrest 100.84 11.67 463 79858 95696 34780914
Drug abuse 96.18 11.67 54 80267 99042 34777568
Febrile neutropenia 94.55 11.67 105 80216 136744 34739866
Thyroid disorder 93.22 11.67 69 80252 3113 34873497
Stress 90.27 11.67 209 80112 30138 34846472
Diarrhoea 89.05 11.67 529 79792 389383 34487227
Headache 88.66 11.67 207 80114 200428 34676182
Renal failure 86.23 11.67 554 79767 130003 34746607
N-terminal prohormone brain natriuretic peptide increased 84.35 11.67 61 80260 2654 34873956
Organising pneumonia 83.68 11.67 85 80236 5894 34870716
Cardiac failure acute 76.00 11.67 107 80214 10463 34866147
Seizure 74.01 11.67 79 80242 104778 34771832
Product dose omission issue 69.12 11.67 105 80216 119606 34757004
Corneal deposits 68.73 11.67 24 80297 200 34876410
Hyperkalaemia 68.22 11.67 328 79993 69061 34807549
Arrhythmia 67.29 11.67 208 80113 35600 34841010
Dyspnoea 66.42 11.67 1224 79097 375558 34501052
Hyperglobulinaemia 66.02 11.67 13 80308 0 34876610
Pericardial haemorrhage 65.71 11.67 56 80265 3102 34873508
Infusion site phlebitis 65.27 11.67 17 80304 42 34876568
Suicidal ideation 65.24 11.67 8 80313 40380 34836230
Blood phosphorus increased 64.39 11.67 84 80237 7637 34868973
Venous pressure jugular increased 64.10 11.67 33 80288 768 34875842
Dyspnoea exertional 64.09 11.67 232 80089 43047 34833563
Anticoagulation drug level increased 63.64 11.67 29 80292 511 34876099
Cornea verticillata 63.64 11.67 17 80304 48 34876562
Atrioventricular block complete 63.56 11.67 92 80229 9227 34867383
Shock haemorrhagic 63.20 11.67 102 80219 11252 34865358
Neutropenia 62.80 11.67 170 80151 156608 34720002
Cerebral haematoma 61.67 11.67 64 80257 4551 34872059
Nasopharyngitis 61.15 11.67 43 80278 69925 34806685
Rash 60.28 11.67 285 80036 222467 34654143
Malignant neoplasm progression 60.28 11.67 68 80253 87978 34788632
Neutrophil count decreased 58.64 11.67 22 80299 51082 34825528
Hyponatraemia 57.71 11.67 356 79965 82335 34794275
Pain in extremity 56.24 11.67 130 80191 126383 34750227
Palpitations 55.56 11.67 210 80111 39776 34836834
Ascites 55.41 11.67 233 80088 46338 34830272
Atrial tachycardia 55.03 11.67 54 80267 3591 34873019
BRASH syndrome 54.07 11.67 26 80295 520 34876090
Thyroxine free increased 53.51 11.67 21 80300 250 34876360
Gastrointestinal haemorrhage 52.66 11.67 366 79955 88111 34788499
Anhedonia 51.90 11.67 75 80246 7510 34869100
Pericardial effusion 51.77 11.67 149 80172 24513 34852097
Sinus node dysfunction 51.60 11.67 56 80265 4193 34872417
Haematuria 50.89 11.67 239 80082 49827 34826783
Ventricular extrasystoles 50.08 11.67 95 80226 11913 34864697
Atrioventricular block first degree 48.82 11.67 65 80256 6027 34870583
Tachycardia induced cardiomyopathy 48.74 11.67 16 80305 108 34876502
Labelled drug-drug interaction medication error 47.88 11.67 106 80215 14833 34861777
Cardioactive drug level increased 47.55 11.67 36 80285 1681 34874929
Exercise tolerance decreased 47.20 11.67 59 80262 5139 34871471
Fatigue 46.64 11.67 587 79734 370066 34506544
Jugular vein distension 46.37 11.67 25 80296 641 34875969
Off label use 45.77 11.67 684 79637 418840 34457770
Disease progression 45.69 11.67 114 80207 107963 34768647
Thyroxine increased 45.22 11.67 14 80307 76 34876534
Muscle spasms 45.01 11.67 64 80257 74937 34801673
Left ventricular failure 44.51 11.67 57 80264 5087 34871523
Injection site pain 44.40 11.67 17 80304 38988 34837622
Therapeutic product effect incomplete 42.93 11.67 32 80289 50509 34826101
Pain 42.76 11.67 285 80036 204390 34672220
Subdural haematoma 42.49 11.67 123 80198 20298 34856312
Coronary artery bypass 41.92 11.67 54 80267 4848 34871762
Phlebitis 41.83 11.67 48 80273 3822 34872788
Intentional product use issue 41.14 11.67 46 80275 59770 34816840
Bundle branch block left 40.74 11.67 59 80262 5920 34870690
Orthopnoea 40.21 11.67 54 80267 5049 34871561
Goitre 39.58 11.67 32 80289 1646 34874964
Electrocardiogram PR prolongation 39.51 11.67 25 80296 870 34875740
Rhabdomyolysis 39.39 11.67 280 80041 67883 34808727
Asthma 38.89 11.67 25 80296 42631 34833979
Deep vein thrombosis 38.83 11.67 56 80265 65192 34811418
Rectal haemorrhage 38.63 11.67 189 80132 40060 34836550
Drug dependence 38.61 11.67 5 80316 24212 34852398
Haematoma 38.52 11.67 138 80183 25467 34851143
Melaena 38.25 11.67 172 80149 35208 34841402
Potentiating drug interaction 38.20 11.67 52 80269 4925 34871685
Musculoskeletal stiffness 37.82 11.67 31 80290 46649 34829961
White blood cell count decreased 37.80 11.67 104 80217 95341 34781269
Nodal arrhythmia 37.45 11.67 24 80297 854 34875756
Rales 37.33 11.67 75 80246 9808 34866802
Drug-induced liver injury 37.25 11.67 148 80173 28684 34847926
Back pain 37.04 11.67 149 80172 121640 34754970
Acute respiratory failure 36.98 11.67 155 80166 30773 34845837
Insomnia 36.98 11.67 119 80202 103788 34772822
Sinusitis 36.75 11.67 25 80296 41377 34835233
Renal injury 36.51 11.67 80 80241 11115 34865495
Keratopathy 36.16 11.67 21 80300 624 34875986
Platelet count decreased 36.07 11.67 147 80174 119570 34757040
Cytomegalovirus infection 35.94 11.67 8 80313 26127 34850483
Cardiac tamponade 35.93 11.67 52 80269 5214 34871396
Rheumatoid arthritis 35.42 11.67 22 80299 38216 34838394
Hepatocellular injury 35.39 11.67 122 80199 22089 34854521
Myalgia 35.32 11.67 89 80232 84021 34792589
Aggression 35.30 11.67 23 80298 38941 34837669
Left atrial enlargement 34.36 11.67 23 80298 882 34875728
Pneumonitis 33.89 11.67 161 80160 33717 34842893
Myoclonus 33.89 11.67 92 80229 14633 34861977
Cardioversion 33.68 11.67 23 80298 912 34875698
Coagulopathy 33.56 11.67 111 80210 19678 34856932
Hypertransaminasaemia 33.46 11.67 52 80269 5554 34871056
Myelosuppression 33.20 11.67 3 80318 19262 34857348
Renal impairment 32.90 11.67 347 79974 94166 34782444
Stomatitis 32.30 11.67 30 80291 42484 34834126
Infusion related reaction 32.10 11.67 45 80276 53012 34823598
Pruritus 32.03 11.67 193 80128 141788 34734822
Activated partial thromboplastin time prolonged 31.67 11.67 65 80256 8630 34867980
Pacemaker generated rhythm 31.46 11.67 10 80311 60 34876550
Anticoagulation drug level above therapeutic 31.30 11.67 31 80290 2085 34874525
Gastrooesophageal reflux disease 30.95 11.67 25 80296 37899 34838711
Nodal rhythm 30.87 11.67 26 80295 1417 34875193
Mucosal inflammation 30.85 11.67 26 80295 38596 34838014
Death 30.77 11.67 689 79632 397360 34479250
Mitochondrial aspartate aminotransferase increased 30.71 11.67 7 80314 7 34876603
Accessory cardiac pathway 30.47 11.67 6 80315 0 34876610
Prothrombin time prolonged 30.43 11.67 67 80254 9339 34867271
Respiratory failure 30.34 11.67 382 79939 108190 34768420
Crepitations 30.18 11.67 37 80284 3159 34873451
Pleural effusion 30.09 11.67 303 80018 81243 34795367
Gravitational oedema 30.03 11.67 19 80302 661 34875949
Fear 29.88 11.67 71 80250 10405 34866205
Hypoaesthesia 29.88 11.67 60 80261 61384 34815226
Haemodynamic instability 29.87 11.67 67 80254 9456 34867154
Optic neuropathy 29.46 11.67 29 80292 1936 34874674
Low cardiac output syndrome 29.41 11.67 18 80303 590 34876020
Migraine 29.39 11.67 3 80318 17475 34859135
Depression 29.38 11.67 119 80202 96979 34779631
Spontaneous haematoma 28.98 11.67 17 80304 515 34876095
Hypersensitivity 28.50 11.67 61 80260 60974 34815636
Tachyarrhythmia 28.15 11.67 38 80283 3570 34873040
Heparin-induced thrombocytopenia 28.10 11.67 48 80273 5547 34871063
Device inappropriate shock delivery 28.02 11.67 8 80313 31 34876579
Cerebral haemorrhage 27.96 11.67 156 80165 34781 34841829
Intraocular haematoma 27.89 11.67 7 80314 14 34876596
Glomerular filtration rate decreased 27.87 11.67 79 80242 12882 34863728
Prostate cancer 27.80 11.67 30 80291 39619 34836991
Sedation 27.76 11.67 7 80314 20999 34855611
Herpes zoster 27.67 11.67 23 80298 34376 34842234
Traumatic lung injury 27.56 11.67 23 80298 1237 34875373
Long QT syndrome 27.36 11.67 33 80288 2770 34873840
Blood pressure increased 27.27 11.67 107 80214 87995 34788615
General physical health deterioration 27.27 11.67 430 79891 127839 34748771
Therapeutic product effect decreased 27.01 11.67 24 80297 34719 34841891
Asthenia 27 11.67 746 79575 244505 34632105
Influenza like illness 26.87 11.67 15 80306 27619 34848991
Urinary tract infection 26.74 11.67 101 80220 83980 34792630
Injury 26.57 11.67 106 80215 20581 34856029
Secondary hyperthyroidism 26.41 11.67 7 80314 19 34876591
Optic ischaemic neuropathy 26.26 11.67 28 80293 2054 34874556
Anastomotic infection 26.11 11.67 10 80311 111 34876499
Blood loss anaemia 26.09 11.67 58 80263 8136 34868474
Chills 26.00 11.67 97 80224 80946 34795664
Xyphoid retraction 25.92 11.67 11 80310 162 34876448
International normalised ratio abnormal 25.83 11.67 35 80286 3300 34873310
Acute pulmonary oedema 25.70 11.67 54 80267 7289 34869321
Blood pressure fluctuation 25.58 11.67 13 80308 25236 34851374
Pancreatitis 25.56 11.67 31 80290 38860 34837750
Blood glucose increased 25.44 11.67 74 80247 66644 34809966
Abdominal distension 25.39 11.67 225 80096 58267 34818343
Halo vision 25.33 11.67 11 80310 172 34876438
Cardiac output decreased 25.21 11.67 19 80302 881 34875729
Diaphragmatic paralysis 25.06 11.67 15 80306 472 34876138
Nephrolithiasis 24.74 11.67 20 80301 30313 34846297
Pulmonary embolism 24.70 11.67 114 80207 89632 34786978
Angiodysplasia 24.61 11.67 17 80304 687 34875923
Hypertension 24.60 11.67 198 80123 136245 34740365
Platelet distribution width increased 24.42 11.67 10 80311 134 34876476
Thyroid function test abnormal 24.20 11.67 17 80304 706 34875904
COVID-19 24.12 11.67 94 80227 77456 34799154
Antiacetylcholine receptor antibody positive 24.00 11.67 8 80313 57 34876553
Alopecia 24.00 11.67 13 80308 24342 34852268
Neuropathy peripheral 23.97 11.67 104 80217 83159 34793451
Presyncope 23.95 11.67 97 80224 18962 34857648
Hepatitis fulminant 23.81 11.67 38 80283 4152 34872458
Ecchymosis 23.78 11.67 50 80271 6753 34869857
Cardio-respiratory arrest 23.67 11.67 212 80109 55061 34821549
Puncture site haematoma 23.58 11.67 10 80311 147 34876463
Loss of personal independence in daily activities 23.38 11.67 25 80296 33154 34843456
Haemothorax 23.36 11.67 36 80285 3816 34872794
Electrocardiogram P wave abnormal 23.34 11.67 10 80311 151 34876459
Periorbital haemorrhage 23.25 11.67 9 80312 103 34876507
Toxic goitre 23.05 11.67 5 80316 3 34876607
Glomerular filtration rate 23.02 11.67 9 80312 106 34876504
Anuria 23.02 11.67 64 80257 10321 34866289
Colitis ulcerative 22.83 11.67 5 80316 16515 34860095
Dry skin 22.69 11.67 23 80298 31264 34845346
Femoral artery aneurysm 22.65 11.67 10 80311 163 34876447
Blood thyroid stimulating hormone decreased 22.56 11.67 25 80296 1916 34874694
Urticaria 22.48 11.67 71 80250 62306 34814304
Arteriosclerotic gangrene 22.47 11.67 8 80313 71 34876539
Urine iodine increased 22.46 11.67 5 80316 4 34876606
Joint swelling 22.42 11.67 67 80254 59823 34816787
Lymphocyte count decreased 22.40 11.67 12 80309 22610 34854000
Fall 21.99 11.67 616 79705 202269 34674341
Blood creatinine increased 21.95 11.67 323 79998 94653 34781957
Iodine uptake abnormal 21.94 11.67 5 80316 5 34876605
Oedema peripheral 21.92 11.67 392 79929 119420 34757190
Cardiorenal syndrome 21.90 11.67 16 80305 707 34875903
Gastrointestinal angiodysplasia 21.89 11.67 15 80306 598 34876012
Pulseless electrical activity 21.80 11.67 50 80271 7161 34869449
Pulmonary oedema 21.76 11.67 185 80136 47344 34829266
Neonatal pneumonia 21.62 11.67 9 80312 126 34876484
Cardiac ventricular disorder 21.60 11.67 11 80310 250 34876360
Atrial thrombosis 21.51 11.67 26 80295 2188 34874422
Myxoedema 21.28 11.67 6 80315 22 34876588
Hepatitis acute 21.13 11.67 51 80270 7550 34869060
Ventricular internal diameter abnormal 21.12 11.67 10 80311 193 34876417
Depressed mood 21.03 11.67 9 80312 19308 34857302
Respiratory distress 20.87 11.67 147 80174 35518 34841092
Infection 20.80 11.67 123 80198 90792 34785818
Product use issue 20.71 11.67 75 80246 63141 34813469
Acute interstitial pneumonitis 20.68 11.67 13 80308 447 34876163
Cholestasis 20.68 11.67 119 80202 26829 34849781
Orthostatic hypertension 20.62 11.67 11 80310 276 34876334
Left ventricular dysfunction 20.55 11.67 60 80261 9947 34866663
Foetal exposure during pregnancy 20.47 11.67 35 80286 38066 34838544
Dyspepsia 20.43 11.67 33 80288 36699 34839911
Drug withdrawal syndrome 20.41 11.67 10 80311 19824 34856786
Dissociation 20.39 11.67 22 80299 1636 34874974
Mitral valve incompetence 20.35 11.67 78 80243 14865 34861745
Abdominal discomfort 20.26 11.67 70 80251 59765 34816845
Cardiac murmur 20.11 11.67 51 80270 7786 34868824
Lupus pneumonitis 20.08 11.67 7 80314 58 34876552
Neonatal hypotension 20.04 11.67 9 80312 153 34876457
Ischaemic stroke 19.93 11.67 89 80232 18161 34858449
Decreased appetite 19.91 11.67 266 80055 166126 34710484
Rhinorrhoea 19.63 11.67 18 80303 25650 34850960
Helicobacter test false negative 19.57 11.67 7 80314 63 34876547
Accidental exposure to product 19.57 11.67 3 80318 12799 34863811
Dyspnoea at rest 19.43 11.67 33 80288 3795 34872815
Anaemia macrocytic 19.37 11.67 29 80292 2997 34873613
Sinoatrial block 19.34 11.67 13 80308 502 34876108
Lymphoid tissue hyperplasia 19.10 11.67 7 80314 68 34876542
Upper respiratory tract infection 19.05 11.67 29 80292 33030 34843580
Bundle branch block 18.90 11.67 16 80305 878 34875732
Drug resistance 18.87 11.67 19 80302 25908 34850702
Withdrawal syndrome 18.86 11.67 3 80318 12452 34864158
Papilloedema 18.82 11.67 27 80294 2686 34873924
Hyperglycaemia 18.81 11.67 39 80282 39441 34837169
Pemphigoid 18.80 11.67 53 80268 8613 34867997
Normocytic anaemia 18.77 11.67 25 80296 2319 34874291
Oropharyngeal pain 18.70 11.67 33 80288 35452 34841158
Myasthenia gravis 18.69 11.67 46 80275 6894 34869716
Bladder cancer 18.68 11.67 7 80314 16271 34860339
Porphyria acute 18.67 11.67 11 80310 336 34876274
Haemoptysis 18.60 11.67 141 80180 34865 34841745
Therapeutic response decreased 18.60 11.67 24 80297 29289 34847321
Cholestatic liver injury 18.60 11.67 25 80296 2339 34874271
Neuroleptic malignant syndrome 18.52 11.67 9 80312 17925 34858685
Abnormal behaviour 18.52 11.67 18 80303 24951 34851659
Osteonecrosis of jaw 18.44 11.67 9 80312 17880 34858730
Supine hypertension 18.32 11.67 11 80310 348 34876262
Influenza 18.27 11.67 56 80265 49610 34827000
Colitis 18.23 11.67 37 80284 37713 34838897
Coma uraemic 18.21 11.67 6 80315 41 34876569
Aerophagia 18.21 11.67 6 80315 41 34876569
Iodine overload 18.08 11.67 4 80317 3 34876607
Nausea 18.04 11.67 620 79701 339288 34537322
Lower respiratory tract infection 17.99 11.67 28 80293 31609 34845001
Injection site erythema 17.97 11.67 7 80314 15892 34860718
Ischaemic cardiomyopathy 17.90 11.67 43 80278 6346 34870264
Conjunctival haemorrhage 17.76 11.67 28 80293 3027 34873583
Angioedema 17.74 11.67 37 80284 37337 34839273
Serotonin syndrome 17.74 11.67 12 80309 19921 34856689
Diffuse vasculitis 17.71 11.67 7 80314 85 34876525
Device pacing issue 17.51 11.67 6 80315 47 34876563
Arteriosclerotic retinopathy 17.39 11.67 5 80316 20 34876590
Hydrops foetalis 17.28 11.67 15 80306 852 34875758
Oesophageal infection 17.16 11.67 10 80311 299 34876311
Lung diffusion test abnormal 17.08 11.67 6 80315 51 34876559
Irritability 16.96 11.67 19 80302 24671 34851939
Neuromyopathy 16.89 11.67 16 80305 1018 34875592
Left ventricular false tendon 16.78 11.67 6 80315 54 34876556
Scrotal haematocoele 16.66 11.67 5 80316 24 34876586
Cellulitis 16.57 11.67 64 80257 52887 34823723
Systemic inflammatory response syndrome 16.53 11.67 43 80278 6666 34869944
Eosinophilia 16.48 11.67 110 80211 26112 34850498
Lung infiltration 16.47 11.67 66 80255 12839 34863771
Hypervolaemia 16.43 11.67 89 80232 19620 34856990
Lymphadenopathy 16.37 11.67 25 80296 28438 34848172
Thyroiditis acute 16.32 11.67 7 80314 106 34876504
Pseudolymphoma 16.24 11.67 13 80308 659 34875951
Muscle haemorrhage 16.23 11.67 30 80291 3688 34872922
Cardiac arrest neonatal 16.17 11.67 5 80316 27 34876583
Haemorrhage intracranial 16.10 11.67 76 80245 15870 34860740
Cardiac pacemaker insertion 16.08 11.67 26 80295 2872 34873738
Inferior vena cava syndrome 16.05 11.67 6 80315 62 34876548
Inappropriate schedule of product administration 16.04 11.67 81 80240 62215 34814395
Ejection fraction abnormal 16.00 11.67 15 80306 942 34875668
Injection site reaction 16 11.67 5 80316 13028 34863582
Paranoia 15.99 11.67 4 80317 12064 34864546
Basal cell carcinoma 15.98 11.67 13 80308 19645 34856965
Neoplasm progression 15.93 11.67 18 80303 23282 34853328
Hospitalisation 15.81 11.67 72 80249 56830 34819780
Subarachnoid haematoma 15.79 11.67 9 80312 258 34876352
Subarachnoid haemorrhage 15.63 11.67 64 80257 12571 34864039
Hirsutism 15.51 11.67 8 80313 187 34876423
Product quality issue 15.50 11.67 10 80311 17025 34859585
Bradyarrhythmia 15.48 11.67 22 80299 2169 34874441
Analgesic therapy 15.47 11.67 15 80306 983 34875627
Heart rate abnormal 15.39 11.67 20 80301 1811 34874799
Osteoporosis 15.30 11.67 5 80316 12663 34863947
Orthostatic hypotension 15.26 11.67 107 80214 25812 34850798
Acute generalised exanthematous pustulosis 15.25 11.67 42 80279 6734 34869876
Systemic-pulmonary artery shunt 15.23 11.67 3 80318 0 34876610
Bone marrow granuloma 15.23 11.67 3 80318 0 34876610
Pseudarthrosis 15.03 11.67 6 80315 75 34876535
Epistaxis 15.02 11.67 202 80119 58049 34818561
Graft versus host disease 15.01 11.67 3 80318 10566 34866044
Dysphagia 15.01 11.67 83 80238 62298 34814312
Leukopenia 14.93 11.67 84 80237 62772 34813838
Acute hepatic failure 14.89 11.67 68 80253 14006 34862604
Musculoskeletal pain 14.87 11.67 32 80289 31931 34844679
Oesophageal achalasia 14.84 11.67 10 80311 388 34876222
Hypophonesis 14.80 11.67 4 80317 12 34876598
Bone marrow failure 14.71 11.67 28 80293 29225 34847385
Deposit eye 14.61 11.67 5 80316 39 34876571
Non-compaction cardiomyopathy 14.61 11.67 5 80316 39 34876571
Blood creatine increased 14.60 11.67 34 80287 4917 34871693
Thyroxine free decreased 14.57 11.67 9 80312 300 34876310
Axonal neuropathy 14.51 11.67 15 80306 1062 34875548
Feeling hot 14.32 11.67 14 80307 19358 34857252
Vascular purpura 14.29 11.67 19 80302 1759 34874851
Tumour lysis syndrome 14.22 11.67 11 80310 17048 34859562
Oedema 14.09 11.67 164 80157 45577 34831033
Erectile dysfunction 14.04 11.67 16 80305 20621 34855989
Emotional distress 14.01 11.67 70 80251 14956 34861654
Pericarditis fungal 13.91 11.67 7 80314 155 34876455
Viral infection 13.90 11.67 12 80309 17611 34858999
Ischaemic hepatitis 13.88 11.67 19 80302 1809 34874801
Hepatitis cholestatic 13.85 11.67 45 80276 7902 34868708
Amaurosis 13.85 11.67 12 80309 680 34875930
Generalised tonic-clonic seizure 13.78 11.67 17 80304 21157 34855453
Suicide attempt 13.76 11.67 45 80276 39071 34837539
Ilium fracture 13.75 11.67 7 80314 159 34876451
Amnesia 13.73 11.67 25 80296 26538 34850072
Chronotropic incompetence 13.72 11.67 4 80317 17 34876593
Abdominal pain upper 13.69 11.67 102 80219 71388 34805222
Illness 13.65 11.67 7 80314 13522 34863088
Mediastinal haemorrhage 13.61 11.67 5 80316 49 34876561
Hepatitis C 13.53 11.67 3 80318 9827 34866783
Ulcer haemorrhage 13.53 11.67 23 80298 2647 34873963
Atrioventricular block second degree 13.42 11.67 28 80293 3760 34872850
Sleep disorder therapy 13.33 11.67 14 80307 1009 34875601
Arthritis 13.28 11.67 33 80288 31313 34845297
Myoglobin urine present 13.25 11.67 7 80314 172 34876438
Osteonecrosis 13.20 11.67 9 80312 14881 34861729
Toxic nodular goitre 13.19 11.67 4 80317 20 34876590
Conduction disorder 13.19 11.67 20 80301 2090 34874520
Alveolitis necrotising 13.19 11.67 4 80317 20 34876590
Proteinuria 13.18 11.67 14 80307 18628 34857982
Ventricular pre-excitation 13.16 11.67 3 80318 3 34876607
Cognitive disorder 13.12 11.67 29 80292 28664 34847946
Psychomotor hyperactivity 13.12 11.67 3 80318 9619 34866991
Myopathy 13.11 11.67 57 80264 11497 34865113
Adrenal haematoma 13.09 11.67 5 80316 55 34876555
Flushing 13.07 11.67 35 80286 32385 34844225
Cardiomegaly 13.06 11.67 70 80251 15368 34861242
Blood pressure decreased 13.01 11.67 178 80143 51337 34825273
Cardiac dysfunction 13.00 11.67 21 80300 2317 34874293
Cell death 12.88 11.67 21 80300 2336 34874274
Fascial rupture 12.88 11.67 4 80317 22 34876588
Ventricular dysfunction 12.84 11.67 28 80293 3877 34872733
Vascular pseudoaneurysm 12.79 11.67 20 80301 2147 34874463
Psoriasis 12.74 11.67 46 80275 38766 34837844
Electrocardiogram QRS complex prolonged 12.71 11.67 32 80289 4862 34871748
Tri-iodothyronine free decreased 12.70 11.67 5 80316 60 34876550
Localised infection 12.67 11.67 13 80308 17574 34859036
Nephroangiosclerosis 12.66 11.67 7 80314 189 34876421
Palmar-plantar erythrodysaesthesia syndrome 12.58 11.67 12 80309 16783 34859827
Type 2 diabetes mellitus 12.55 11.67 11 80310 16021 34860589
Linear IgA disease 12.50 11.67 17 80304 1609 34875001
Hyponatraemic syndrome 12.49 11.67 7 80314 194 34876416
Pulmonary vascular resistance abnormality 12.42 11.67 5 80316 64 34876546
Tri-iodothyronine increased 12.35 11.67 5 80316 65 34876545
Body temperature increased 12.33 11.67 13 80308 17355 34859255
Prothrombin time shortened 12.32 11.67 16 80305 1448 34875162
Hot flush 12.30 11.67 14 80307 18052 34858558
Traumatic haemothorax 12.25 11.67 8 80313 294 34876316
Subdural haematoma evacuation 12.18 11.67 4 80317 27 34876583
Blood uric acid increased 12.10 11.67 49 80272 9575 34867035
Bone pain 12.06 11.67 18 80303 20668 34855942
Tooth disorder 11.96 11.67 5 80316 10877 34865733
Acute lung injury 11.93 11.67 16 80305 1494 34875116
Lymphoma 11.85 11.67 7 80314 12500 34864110
Optic nerve infarction 11.82 11.67 4 80317 30 34876580
Electrocardiogram low voltage 11.82 11.67 4 80317 30 34876580
Sinus arrhythmia 11.81 11.67 12 80309 832 34875778
Iron deficiency anaemia 11.75 11.67 51 80270 10278 34866332
Wolff-Parkinson-White syndrome 11.73 11.67 7 80314 219 34876391
Failure to suspend medication 11.72 11.67 9 80312 429 34876181
Bundle branch block right 11.72 11.67 41 80280 7475 34869135
Hepatic cirrhosis 11.72 11.67 74 80247 17240 34859370
Therapeutic drug monitoring analysis not performed 11.72 11.67 10 80311 555 34876055
Fasting 11.71 11.67 4 80317 31 34876579
Dry gangrene 11.71 11.67 9 80312 430 34876180

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperthyroidism 2561.45 11.00 1044 121989 21165 79600190
Drug interaction 1653.58 11.00 2568 120465 412615 79208740
Bradycardia 1287.40 11.00 1299 121734 134258 79487097
Torsade de pointes 1043.76 11.00 536 122497 18776 79602579
Electrocardiogram QT prolonged 1013.01 11.00 949 122084 89437 79531918
Pulmonary toxicity 998.50 11.00 458 122575 12456 79608899
Interstitial lung disease 949.72 11.00 1013 122020 111587 79509768
Atrial fibrillation 888.42 11.00 1297 121736 196589 79424766
Ventricular tachycardia 847.14 11.00 620 122413 41315 79580040
Cardiac failure 785.11 11.00 1076 121957 153766 79467589
Acute kidney injury 620.80 11.00 1983 121050 517421 79103934
Cardiogenic shock 557.61 11.00 485 122548 41429 79579926
Hypothyroidism 537.05 11.00 524 122509 51868 79569487
Thyroiditis 508.40 11.00 210 122823 4395 79616960
International normalised ratio increased 505.21 11.00 638 122395 84083 79537272
Myxoedema coma 444.94 11.00 121 122912 616 79620739
Ventricular fibrillation 444.05 11.00 379 122654 31547 79589808
Hypotension 328.11 11.00 1446 121587 438871 79182484
Sinus bradycardia 327.39 11.00 288 122745 24959 79596396
Arthralgia 314.82 11.00 253 122780 571550 79049805
Thyrotoxic crisis 309.95 11.00 104 122929 1180 79620175
Syncope 299.58 11.00 774 122259 178675 79442680
Multiple organ dysfunction syndrome 298.76 11.00 607 122426 119639 79501716
Headache 289.98 11.00 350 122683 653422 78967933
Cardiac failure congestive 270.09 11.00 645 122388 141757 79479598
Cardiac arrest 261.61 11.00 717 122316 171379 79449976
Pain 261.16 11.00 428 122605 703374 78917981
Hyperkalaemia 259.07 11.00 556 122477 113842 79507513
Renal failure 253.32 11.00 783 122250 200185 79421170
Pulmonary fibrosis 248.33 11.00 323 122710 43789 79577566
Hyponatraemia 245.92 11.00 716 122317 177132 79444223
Atrial flutter 230.35 11.00 221 122812 21404 79599951
Appendicolith 223.06 11.00 148 122885 8403 79612952
Alopecia 221.23 11.00 44 122989 231311 79390044
Joint swelling 216.79 11.00 87 122946 288559 79332796
Ventricular arrhythmia 206.75 11.00 143 122890 8697 79612658
Gastrointestinal haemorrhage 205.40 11.00 596 122437 147123 79474232
Pulmonary alveolar haemorrhage 194.96 11.00 153 122880 11304 79610051
Atrioventricular block 193.79 11.00 166 122867 13875 79607480
Haematoma 192.67 11.00 313 122720 51882 79569473
Nasopharyngitis 191.48 11.00 76 122957 253805 79367550
Shock haemorrhagic 185.84 11.00 190 122843 19870 79601485
Rheumatoid arthritis 180.74 11.00 49 122984 208421 79412934
Rash 179.72 11.00 391 122642 577967 79043388
Infusion related reaction 176.80 11.00 67 122966 230170 79391185
Therapeutic product effect decreased 174.90 11.00 23 123010 163840 79457515
Synovitis 173.93 11.00 16 123017 150718 79470637
Sinus node dysfunction 171.75 11.00 121 122912 7580 79613775
Sinusitis 169.39 11.00 46 122987 195455 79425900
Acute respiratory distress syndrome 165.01 11.00 266 122767 43801 79577554
Arthropathy 164.52 11.00 36 122997 177075 79444280
Tachyarrhythmia 159.02 11.00 111 122922 6851 79614504
Fatigue 153.50 11.00 827 122206 928900 78692455
Hypersensitivity 152.99 11.00 109 122924 262130 79359225
Pain in extremity 149.04 11.00 207 122826 364331 79257024
Pyrexia 144.66 11.00 549 122484 678160 78943195
Drug intolerance 143.59 11.00 118 122915 264001 79357354
Blood thyroid stimulating hormone increased 138.53 11.00 117 122916 9591 79611764
Rhabdomyolysis 138.40 11.00 411 122622 102720 79518635
Hand deformity 138.09 11.00 5 123028 103914 79517441
Arrhythmia 137.70 11.00 297 122736 60975 79560380
Musculoskeletal stiffness 137.58 11.00 49 122984 174959 79446396
Systemic lupus erythematosus 136.75 11.00 14 123019 121135 79500220
Labelled drug-drug interaction medication error 136.57 11.00 190 122843 27460 79593895
Completed suicide 135.84 11.00 108 122925 245659 79375696
Lung disorder 135.83 11.00 349 122684 80208 79541147
Cerebral haematoma 135 11.00 106 122927 7836 79613519
Melaena 133.25 11.00 292 122741 60598 79560757
Appendicitis 132.48 11.00 162 122871 20632 79600723
Pemphigus 131.60 11.00 5 123028 99577 79521778
Cardiac failure chronic 128.54 11.00 119 122914 11016 79610339
Glossodynia 124.66 11.00 9 123024 103328 79518027
Haematuria 123.13 11.00 305 122728 68531 79552824
Ventricular extrasystoles 123.09 11.00 152 122881 19552 79601803
Atrioventricular block complete 120.02 11.00 138 122895 16472 79604883
Ejection fraction decreased 119.06 11.00 201 122832 34376 79586979
Swelling 118.79 11.00 96 122937 216615 79404740
Organising pneumonia 118.78 11.00 113 122920 10826 79610529
Cerebral haemorrhage 117.71 11.00 269 122764 57404 79563951
Stomatitis 117.22 11.00 40 122993 146717 79474638
Diarrhoea 115.29 11.00 841 122192 879648 78741707
Maternal exposure during pregnancy 112.96 11.00 35 122998 136503 79484852
Hyperglobulinaemia 112.19 11.00 21 123012 3 79621352
Abdominal discomfort 111.03 11.00 134 122899 250593 79370762
Pericardial haemorrhage 108.15 11.00 74 122959 4421 79616934
Injection site pain 107.92 11.00 33 123000 129805 79491550
Long QT syndrome 106.70 11.00 82 122951 5873 79615482
Hypoaesthesia 105.28 11.00 74 122959 179278 79442077
Infusion site phlebitis 105.07 11.00 28 123005 130 79621225
Cardiac failure acute 104.01 11.00 137 122896 18792 79602563
Orthopnoea 103.61 11.00 101 122932 9972 79611383
Anaemia 102.45 11.00 1093 121940 443922 79177433
Migraine 101.68 11.00 9 123024 87484 79533871
Dyspnoea 97.11 11.00 1857 121176 855168 78766187
Therapeutic product effect incomplete 96.39 11.00 49 122984 141596 79479759
Back pain 95.63 11.00 204 122829 303976 79317379
Respiratory failure 95.10 11.00 539 122494 180372 79440983
Product dose omission issue 94.79 11.00 147 122886 247390 79373965
Rectal haemorrhage 94.78 11.00 296 122737 76004 79545351
Febrile neutropenia 94.49 11.00 131 122902 230868 79390487
Blood phosphorus increased 94.02 11.00 97 122936 10250 79611105
Cardioactive drug level increased 93.86 11.00 63 122970 3646 79617709
Corneal deposits 91.85 11.00 33 123000 465 79620890
Subdural haematoma 90.53 11.00 169 122864 31265 79590090
Cholestasis 89.11 11.00 227 122806 51882 79569473
Cornea verticillata 89.05 11.00 25 123008 146 79621209
Cardio-respiratory arrest 88.63 11.00 367 122666 108143 79513212
Product use issue 87.82 11.00 117 122916 209705 79411650
Hepatocellular injury 86.29 11.00 212 122821 47381 79573974
Renal injury 86.11 11.00 118 122915 16809 79604546
Fibromyalgia 85.81 11.00 3 123030 64337 79557018
Muscle spasms 85.46 11.00 86 122947 174644 79446711
Mitral valve incompetence 85.31 11.00 156 122877 28409 79592946
Anticoagulation drug level increased 84.56 11.00 35 122998 736 79620619
Asthma 84.34 11.00 52 122981 135043 79486312
Urticaria 84.09 11.00 97 122936 185104 79436251
Atrioventricular block first degree 83.95 11.00 100 122933 12391 79608964
Intentional product use issue 83.81 11.00 67 122966 152045 79469310
Lower respiratory tract infection 83.11 11.00 48 122985 129172 79492183
Wound 82.38 11.00 38 122995 116141 79505214
Cardioversion 82.00 11.00 47 122986 2051 79619304
Off label use 81.57 11.00 952 122081 906263 78715092
Hypokalaemia 80.93 11.00 437 122596 143603 79477752
Acute respiratory failure 80.52 11.00 238 122795 59303 79562052
Infection 80.29 11.00 157 122876 241555 79379800
Alveolitis 80.29 11.00 60 122973 4120 79617235
Pruritus 80.18 11.00 325 122708 394323 79227032
Pneumonitis 79.21 11.00 240 122793 60620 79560735
Respiratory distress 78.71 11.00 233 122800 58106 79563249
Coronary artery bypass 78.26 11.00 69 122964 5993 79615362
Lactic acidosis 76.62 11.00 261 122772 70098 79551257
Nausea 75.04 11.00 1034 121999 956162 78665193
Discomfort 74.80 11.00 51 122982 125566 79495789
Pleural effusion 74.49 11.00 430 122603 144832 79476523
Atrial tachycardia 74.26 11.00 72 122961 7061 79614294
Coagulopathy 73.52 11.00 168 122865 35838 79585517
N-terminal prohormone brain natriuretic peptide increased 73.44 11.00 60 122973 4695 79616660
Ascites 73.43 11.00 270 122763 75292 79546063
Arthritis 73.41 11.00 43 122990 114837 79506518
Insomnia 71.67 11.00 171 122862 244999 79376356
Myalgia 71.28 11.00 110 122923 185531 79435824
Fall 70.70 11.00 1100 121933 486529 79134826
Peripheral swelling 70.44 11.00 199 122834 269418 79351937
Injection site erythema 70.38 11.00 17 123016 78180 79543175
Drug-induced liver injury 70.02 11.00 243 122790 65874 79555481
Blood loss anaemia 69.90 11.00 102 122931 15396 79605959
Coronary artery disease 69.65 11.00 241 122792 65233 79556122
Renal impairment 69.47 11.00 449 122584 157334 79464021
Neuromyopathy 69.31 11.00 38 122995 1520 79619835
Bundle branch block left 69.01 11.00 87 122946 11426 79609929
Hypoxia 67.60 11.00 327 122706 102916 79518439
Keratopathy 66.97 11.00 34 122999 1160 79620195
Pericardial effusion 66.54 11.00 189 122844 46048 79575307
Psoriatic arthropathy 66.31 11.00 19 123014 77980 79543375
Folliculitis 66.28 11.00 5 123028 55375 79565980
Venous pressure jugular increased 66.09 11.00 35 122998 1305 79620050
Nodal arrhythmia 65.98 11.00 40 122993 1938 79619417
Ischaemic stroke 65.90 11.00 153 122880 32978 79588377
Drug abuse 65.77 11.00 93 122940 162598 79458757
Gastrooesophageal reflux disease 65.24 11.00 40 122993 104206 79517149
Neutrophil count decreased 64.67 11.00 32 123001 93927 79527428
Rales 64.56 11.00 113 122920 19888 79601467
Exposure during pregnancy 64.41 11.00 38 122995 101094 79520261
Anhedonia 64.24 11.00 96 122937 14802 79606553
Dyspnoea exertional 63.79 11.00 285 122748 86788 79534567
Tachycardia induced cardiomyopathy 63.64 11.00 20 123013 181 79621174
Left ventricular dysfunction 63.29 11.00 110 122923 19251 79602104
Potentiating drug interaction 63.26 11.00 73 122960 8746 79612609
Depression 61.94 11.00 153 122880 216637 79404718
Ill-defined disorder 61.93 11.00 13 123020 65862 79555493
Cardiac tamponade 61.91 11.00 74 122959 9202 79612153
Hypersensitivity myocarditis 61.90 11.00 21 123012 247 79621108
Spontaneous haematoma 61.38 11.00 34 122999 1388 79619967
Irritable bowel syndrome 61.22 11.00 11 123022 62230 79559125
Pericarditis 61.16 11.00 43 122990 104193 79517162
White blood cell count decreased 61.05 11.00 124 122909 188164 79433191
Heparin-induced thrombocytopenia 60.97 11.00 75 122958 9607 79611748
Abdominal pain upper 60.84 11.00 162 122871 223657 79397698
Anuria 60.73 11.00 113 122920 20850 79600505
Thyroxine free increased 60.26 11.00 32 123001 1200 79620155
Herpes zoster 59.25 11.00 35 122998 93048 79528307
Arterial haemorrhage 58.88 11.00 41 122992 2520 79618835
Ecchymosis 58.57 11.00 93 122940 15113 79606242
Thyroid disorder 58.26 11.00 89 122944 13990 79607365
Nodal rhythm 57.99 11.00 44 122989 3091 79618264
Electrocardiogram PR prolongation 57.98 11.00 34 122999 1549 79619806
BRASH syndrome 57.16 11.00 29 123004 988 79620367
Anticoagulation drug level above therapeutic 56.59 11.00 46 122987 3574 79617781
Oropharyngeal pain 55.57 11.00 52 122981 109301 79512054
Left ventricular failure 55.21 11.00 71 122962 9510 79611845
Activated partial thromboplastin time prolonged 54.77 11.00 87 122946 14141 79607214
General physical health deterioration 54.60 11.00 657 122376 274581 79346774
Injection site reaction 53.20 11.00 10 123023 54775 79566580
Thyroxine increased 52.79 11.00 25 123008 731 79620624
Suicidal ideation 52.54 11.00 26 123007 76314 79545041
Oedema peripheral 52.14 11.00 607 122426 251681 79369674
Influenza like illness 51.54 11.00 23 123010 71684 79549671
Bradyarrhythmia 51.16 11.00 46 122987 4100 79617255
Seizure 51.07 11.00 137 122896 188697 79432658
Palpitations 50.14 11.00 351 122682 126259 79495096
COVID-19 50.12 11.00 105 122928 157569 79463786
Acute pulmonary oedema 49.35 11.00 83 122950 14147 79607208
Eosinophilia 49.17 11.00 168 122865 45177 79576178
Hepatitis acute 49.12 11.00 87 122946 15455 79605900
Blood pressure fluctuation 49.11 11.00 21 123012 67124 79554231
C-reactive protein abnormal 48.78 11.00 8 123025 48359 79572996
Goitre 48.66 11.00 51 122982 5488 79615867
Blood creatinine increased 47.56 11.00 405 122628 154652 79466703
Glomerular filtration rate decreased 47.54 11.00 107 122926 22595 79598760
Haemorrhage 47.52 11.00 271 122762 90847 79530508
Sedation 47.25 11.00 11 123022 51884 79569471
Septic shock 47.21 11.00 338 122695 122463 79498892
Musculoskeletal pain 47.10 11.00 53 122980 102301 79519054
Presyncope 47.09 11.00 155 122878 40899 79580456
Cardiac ablation 47.02 11.00 34 122999 2219 79619136
Hepatitis fulminant 46.94 11.00 57 122976 7205 79614150
Pulmonary hypertension 46.87 11.00 172 122861 47908 79573447
Iodine overload 46.70 11.00 9 123024 3 79621352
Drug level increased 46.64 11.00 151 122882 39500 79581855
Haemarthrosis 46.63 11.00 51 122982 5761 79615594
Blister 46.61 11.00 70 122963 119406 79501949
Weight increased 46.44 11.00 245 122788 277141 79344214
Blood pressure increased 46.11 11.00 169 122864 211191 79410164
Exercise tolerance decreased 45.78 11.00 63 122970 9008 79612347
Malignant neoplasm progression 45.41 11.00 88 122945 135902 79485453
Prothrombin time prolonged 45.14 11.00 88 122945 16811 79604544
Rhinorrhoea 45.13 11.00 31 123002 76043 79545312
Haematoma muscle 44.65 11.00 35 122998 2580 79618775
Jugular vein distension 44.64 11.00 28 123005 1442 79619913
Toxic skin eruption 44.39 11.00 103 122930 22190 79599165
Knee arthroplasty 43.96 11.00 7 123026 43241 79578114
Haemorrhage intracranial 43.63 11.00 113 122920 26080 79595275
Myxoedema 43.58 11.00 14 123019 137 79621218
Subarachnoid haemorrhage 43.30 11.00 108 122925 24357 79596998
Type 2 diabetes mellitus 43.18 11.00 17 123016 57105 79564250
Drug dependence 42.82 11.00 6 123027 40763 79580592
Lymphatic fistula 42.53 11.00 22 123011 781 79620574
Acute hepatic failure 42.27 11.00 122 122911 29991 79591364
Prothrombin time shortened 42.19 11.00 37 122996 3191 79618164
Upper respiratory tract infection 42.17 11.00 47 122986 91121 79530234
Muscle haemorrhage 41.62 11.00 50 122983 6250 79615105
Femoral hernia incarcerated 41.55 11.00 22 123011 820 79620535
Neutropenia 41.29 11.00 267 122766 287443 79333912
Stress 41.00 11.00 236 122797 79376 79541979
Fear 40.98 11.00 99 122934 21887 79599468
Hip arthroplasty 40.68 11.00 4 123029 35752 79585603
Pulmonary oedema 40.59 11.00 254 122779 88000 79533355
Chills 40.55 11.00 120 122913 160114 79461241
Haemorrhagic stroke 40.41 11.00 66 122967 10980 79610375
Cerebellar syndrome 40.38 11.00 46 122987 5434 79615921
Mixed liver injury 40.33 11.00 54 122979 7524 79613831
Haemodynamic instability 39.89 11.00 85 122948 17297 79604058
Optic neuropathy 39.76 11.00 37 122996 3447 79617908
Low cardiac output syndrome 39.75 11.00 23 123010 1022 79620333
Lung infiltration 39.36 11.00 100 122933 22812 79598543
Tricuspid valve incompetence 39.16 11.00 91 122942 19621 79601734
Contraindicated product administered 39.13 11.00 119 122914 157419 79463936
Gravitational oedema 38.94 11.00 28 123005 1811 79619544
Myocardial infarction 38.91 11.00 445 122588 183684 79437671
Toxicity to various agents 38.53 11.00 886 122147 420654 79200701
Shock 38.50 11.00 151 122882 43397 79577958
Psoriasis 38.44 11.00 49 122984 89538 79531817
Osteoarthritis 38.25 11.00 47 122986 87262 79534093
Treatment failure 38.05 11.00 135 122898 170351 79451004
Asthenia 38.05 11.00 1046 121987 510643 79110712
Acute generalised exanthematous pustulosis 38.02 11.00 83 122950 17171 79604184
Myelosuppression 37.78 11.00 8 123025 40288 79581067
Disease progression 37.26 11.00 152 122881 184210 79437145
Feeling hot 37.26 11.00 23 123010 59711 79561644
Craniocerebral injury 37.25 11.00 43 122990 5153 79616202
Haemoptysis 37.09 11.00 178 122855 55821 79565534
Device pacing issue 36.77 11.00 12 123021 124 79621231
Left atrial enlargement 36.75 11.00 23 123010 1180 79620175
Mobility decreased 36.65 11.00 84 122949 122091 79499264
Adverse event 36.44 11.00 24 123009 60190 79561165
Loss of personal independence in daily activities 36.36 11.00 64 122969 102516 79518839
Brugada syndrome 36.14 11.00 23 123010 1215 79620140
Swelling face 36.01 11.00 34 122999 71178 79550177
Bursitis 35.99 11.00 6 123027 35838 79585517
Wheezing 35.98 11.00 79 122954 116585 79504770
Red blood cell sedimentation rate increased 35.85 11.00 13 123020 45929 79575426
Haemothorax 35.41 11.00 43 122990 5435 79615920
Hypervolaemia 35.32 11.00 145 122888 42545 79578810
Pancreatic steatosis 35.25 11.00 22 123011 1123 79620232
Wound infection pseudomonas 35.06 11.00 25 123008 1596 79619759
Head injury 35.02 11.00 132 122901 37237 79584118
Pacemaker generated rhythm 34.98 11.00 10 123023 63 79621292
Optic ischaemic neuropathy 34.86 11.00 32 123001 2929 79618426
Myopathy 34.54 11.00 89 122944 20474 79600881
Hepatic failure 34.54 11.00 186 122847 61026 79560329
Ischaemic hepatitis 34.47 11.00 35 122998 3629 79617726
Cardiac output decreased 34.45 11.00 26 123007 1812 79619543
Abdominal wall haematoma 34.38 11.00 40 122993 4833 79616522
Abortion spontaneous 34.37 11.00 3 123030 29504 79591851
Sinoatrial block 34.31 11.00 23 123010 1328 79620027
Dyspnoea at rest 34.30 11.00 49 122984 7253 79614102
Injection site swelling 34.05 11.00 15 123018 47117 79574238
Myoclonus 34.05 11.00 107 122926 27553 79593802
Phlebitis 34.00 11.00 54 122979 8776 79612579
Night sweats 33.99 11.00 19 123014 52076 79569279
Blood creatine increased 33.93 11.00 56 122977 9399 79611956
International normalised ratio abnormal 33.64 11.00 43 122990 5725 79615630
Cardiac murmur 33.60 11.00 75 122958 15749 79605606
Impaired healing 33.57 11.00 52 122981 87603 79533752
Mitochondrial aspartate aminotransferase increased 33.49 11.00 7 123026 7 79621348
Sudden death 33.35 11.00 93 122940 22418 79598937
Illness 33.29 11.00 15 123018 46496 79574859
Drug hypersensitivity 33.15 11.00 298 122735 298618 79322737
Throat irritation 32.96 11.00 11 123022 40935 79580420
Atrial thrombosis 32.72 11.00 34 122999 3622 79617733
Neck pain 32.61 11.00 41 122992 75376 79545979
Colitis ulcerative 32.36 11.00 7 123026 34735 79586620
Feeling abnormal 32.33 11.00 131 122902 159068 79462287
Osteoporosis 32.16 11.00 22 123011 54090 79567265
Secondary hyperthyroidism 32.14 11.00 9 123024 52 79621303
Extravasation 32.00 11.00 34 122999 3716 79617639
Cytomegalovirus infection 31.72 11.00 13 123020 42631 79578724
Oral herpes 31.42 11.00 3 123030 27451 79593904
Bone pain 31.39 11.00 24 123009 55718 79565637
Injection site bruising 31.32 11.00 12 123021 40990 79580365
Lymphocyte count decreased 31.21 11.00 17 123016 47272 79574083
Inappropriate schedule of product administration 31.04 11.00 104 122929 133524 79487831
Glomerular filtration rate 31.01 11.00 11 123022 149 79621206
Angiodysplasia 31.00 11.00 20 123013 1082 79620273
Ischaemic cardiomyopathy 30.93 11.00 48 122985 7647 79613708
Cardiac disorder 30.70 11.00 190 122843 65567 79555788
Deep vein thrombosis 30.27 11.00 91 122942 120828 79500527
Xyphoid retraction 30.17 11.00 11 123022 162 79621193
Ear infection 29.99 11.00 8 123025 34424 79586931
Anaemia macrocytic 29.96 11.00 40 122993 5557 79615798
Oliguria 29.93 11.00 73 122960 16236 79605119
Respiratory acidosis 29.52 11.00 58 122975 11142 79610213
Memory impairment 29.49 11.00 82 122951 111652 79509703
Neoplasm progression 29.42 11.00 22 123011 51660 79569695
Osteonecrosis of jaw 29.32 11.00 15 123018 43211 79578144
Hypertension 29.31 11.00 348 122685 330644 79290711
Blood thyroid stimulating hormone decreased 29.30 11.00 40 122993 5676 79615679
Hot flush 29.19 11.00 25 123008 54852 79566503
Suicide attempt 29.15 11.00 52 122981 82880 79538475
Acute interstitial pneumonitis 29.10 11.00 20 123013 1203 79620152
Fungal infection 29.05 11.00 14 123019 41734 79579621
Cardiovascular insufficiency 29.00 11.00 29 123004 2952 79618403
Pancreatitis 28.91 11.00 38 122995 68537 79552818
Hypoglycaemia 28.87 11.00 261 122772 101333 79520022
Pulseless electrical activity 28.83 11.00 66 122967 14094 79607261
Cataract 28.76 11.00 32 123001 62088 79559267
Nasal congestion 28.75 11.00 46 122987 76506 79544849
Influenza 28.67 11.00 103 122930 129503 79491852
Anastomotic infection 28.29 11.00 10 123023 134 79621221
Palmar-plantar erythrodysaesthesia syndrome 28.29 11.00 8 123025 33126 79588229
Therapeutic response decreased 28.23 11.00 37 122996 66816 79554539
Platelet distribution width increased 28.22 11.00 10 123023 135 79621220
Femoral artery aneurysm 28.20 11.00 11 123022 197 79621158
Intraocular haematoma 28.18 11.00 7 123026 23 79621332
Right ventricular failure 28.10 11.00 90 122943 23407 79597948
Cardiomegaly 28.02 11.00 97 122936 26255 79595100
Ear pain 27.95 11.00 8 123025 32861 79588494
Orthostatic hypotension 27.94 11.00 165 122868 55999 79565356
Mediastinal haematoma 27.65 11.00 11 123022 208 79621147
Epistaxis 27.49 11.00 278 122755 111237 79510118
Nephrolithiasis 27.47 11.00 25 123008 53266 79568089
Toxic goitre 27.31 11.00 7 123026 27 79621328
Ventricular tachyarrhythmia 26.93 11.00 13 123020 397 79620958
Urinary tract infection 26.92 11.00 282 122751 274230 79347125
Cerebellar haematoma 26.89 11.00 15 123018 621 79620734
Cystitis 26.87 11.00 25 123008 52707 79568648
Basal cell carcinoma 26.84 11.00 12 123021 37363 79583992
Gastrointestinal angiodysplasia 26.67 11.00 18 123015 1051 79620304
Papilloedema 26.64 11.00 40 122993 6193 79615162
Mouth ulceration 26.53 11.00 13 123020 38381 79582974
Traumatic lung injury 26.53 11.00 25 123008 2366 79618989
Gastrointestinal disorder 26.45 11.00 98 122935 122107 79499248
Neonatal hypotension 26.36 11.00 7 123026 32 79621323
Lower gastrointestinal haemorrhage 26.27 11.00 69 122964 16056 79605299
Tendonitis 26.25 11.00 3 123030 23827 79597528
Cardioactive drug level above therapeutic 25.99 11.00 11 123022 245 79621110
Hepatic enzyme increased 25.91 11.00 170 122863 182440 79438915
Depressed mood 25.89 11.00 22 123011 48458 79572897
Puncture site haematoma 25.85 11.00 10 123023 175 79621180
Antiacetylcholine receptor antibody positive 25.80 11.00 8 123025 69 79621286
Intentional overdose 25.63 11.00 81 122952 105879 79515476
Eosinophilic pneumonia 25.49 11.00 36 122997 5274 79616081
Seroma 25.43 11.00 24 123009 2276 79619079
Hepatitis cholestatic 25.41 11.00 62 122971 13790 79607565
Arteriosclerotic gangrene 25.40 11.00 8 123025 73 79621282
Periorbital haemorrhage 25.39 11.00 11 123022 260 79621095
Extrasystoles 25.36 11.00 43 122990 7376 79613979
Cellulitis 25.25 11.00 85 122948 108975 79512380
Drug withdrawal syndrome 25.16 11.00 11 123022 34707 79586648
Thyroiditis acute 25.05 11.00 10 123023 191 79621164
Platelet count decreased 24.79 11.00 187 122846 194477 79426878
Chronic kidney disease 24.78 11.00 181 122852 65973 79555382
Ilium fracture 24.78 11.00 11 123022 276 79621079
Intraventricular haemorrhage 24.75 11.00 34 122999 4853 79616502
Hypertransaminasaemia 24.74 11.00 56 122977 11868 79609487
Retroperitoneal haemorrhage 24.67 11.00 36 122997 5434 79615921
Flushing 24.64 11.00 63 122970 88205 79533150
Amnesia 24.53 11.00 37 122996 63020 79558335
Atrioventricular block second degree 24.50 11.00 42 122991 7270 79614085
Cholestatic liver injury 24.46 11.00 34 122999 4907 79616448
Intra-abdominal haematoma 24.30 11.00 26 123007 2865 79618490
Accidental exposure to product 24.21 11.00 9 123024 31313 79590042
Myasthenia gravis 24.03 11.00 51 122982 10348 79611007
Iodine uptake abnormal 23.92 11.00 5 123028 5 79621350
Urine iodine increased 23.92 11.00 5 123028 5 79621350
Acute coronary syndrome 23.53 11.00 79 122954 21054 79600301
Mucosal inflammation 23.45 11.00 51 122982 75529 79545826
Pemphigoid 23.41 11.00 64 122969 15251 79606104
Sciatica 23.34 11.00 11 123022 33211 79588144
Anaphylactic reaction 23.20 11.00 60 122973 83683 79537672
Device inappropriate shock delivery 23.15 11.00 7 123026 55 79621300
Haemorrhagic diathesis 23.14 11.00 37 122996 6047 79615308
Paraesthesia 23.11 11.00 168 122865 176155 79445200
Ventricular internal diameter abnormal 22.86 11.00 10 123023 242 79621113
Cell death 22.77 11.00 32 123001 4667 79616688
Body temperature increased 22.70 11.00 21 123012 44399 79576956
Skin disorder 22.69 11.00 12 123021 33931 79587424
Tri-iodothyronine increased 22.67 11.00 10 123023 247 79621108
Joint stiffness 22.45 11.00 18 123015 40812 79580543
Jaundice 22.35 11.00 150 122883 53199 79568156
Aortic valve incompetence 22.33 11.00 47 122986 9483 79611872
Helicobacter test false negative 22.31 11.00 7 123026 63 79621292
Vomiting 22.20 11.00 822 122211 665006 78956349
Erythema 22.04 11.00 229 122804 223061 79398294
Halo vision 21.94 11.00 13 123020 604 79620751
Supraventricular extrasystoles 21.93 11.00 39 122994 6948 79614407
Pharyngitis 21.90 11.00 4 123029 22371 79598984
Mitral valve disease mixed 21.90 11.00 4 123029 0 79621355
Dry skin 21.83 11.00 45 122988 67950 79553405
Neonatal pneumonia 21.83 11.00 6 123027 32 79621323
Progressive multifocal leukoencephalopathy 21.71 11.00 3 123030 20597 79600758
Cardiac pacemaker insertion 21.59 11.00 35 122998 5787 79615568
Alveolar proteinosis 21.41 11.00 14 123019 775 79620580
Myocardial ischaemia 21.36 11.00 87 122946 25432 79595923
Product quality issue 21.26 11.00 13 123020 33927 79587428
Vascular purpura 21.14 11.00 25 123008 3073 79618282
Inflammation 21.07 11.00 74 122959 93679 79527676
C-reactive protein increased 21.00 11.00 115 122918 128912 79492443
Conduction disorder 20.99 11.00 26 123007 3353 79618002
Accessory cardiac pathway 20.99 11.00 5 123028 13 79621342
Full blood count abnormal 20.85 11.00 19 123014 40455 79580900
Procedural pain 20.80 11.00 5 123028 23079 79598276
Supine hypertension 20.70 11.00 11 123022 413 79620942
Acne 20.70 11.00 8 123025 27182 79594173
Device capturing issue 20.70 11.00 6 123027 40 79621315
Lupus pneumonitis 20.66 11.00 7 123026 82 79621273
Swollen joint count increased 20.59 11.00 5 123028 22922 79598433
Analgesic therapy 20.54 11.00 15 123018 994 79620361
Orthostatic hypertension 20.54 11.00 14 123019 831 79620524
Coma uraemic 20.44 11.00 6 123027 42 79621313
Electrocardiogram QRS complex prolonged 20.42 11.00 49 122984 10784 79610571
Blood pressure decreased 20.37 11.00 239 122794 99227 79522128
Bundle branch block right 20.26 11.00 50 122983 11201 79610154
Bundle branch block 20.23 11.00 18 123015 1582 79619773
Viral infection 20.08 11.00 22 123011 42994 79578361
Hypophonesis 20.00 11.00 5 123028 17 79621338
Subcutaneous haematoma 19.94 11.00 23 123010 2754 79618601
Obesity 19.93 11.00 15 123018 35110 79586245
Central nervous system injury 19.93 11.00 8 123025 155 79621200
Retroperitoneal haematoma 19.85 11.00 32 123001 5265 79616090
Listless 19.76 11.00 27 123006 3834 79617521
Left ventricular false tendon 19.75 11.00 6 123027 48 79621307
Ventricular pre-excitation 19.67 11.00 4 123029 3 79621352
Aerophagia 19.64 11.00 6 123027 49 79621306
Cyanosis 19.63 11.00 84 122949 25098 79596257
Arrhythmia supraventricular 19.43 11.00 20 123013 2107 79619248
Gastroenteritis viral 19.42 11.00 7 123026 24824 79596531
Osteonecrosis 19.35 11.00 12 123021 31083 79590272
Thyroid function test abnormal 19.29 11.00 24 123009 3110 79618245
Photosensitivity reaction 19.27 11.00 74 122959 21053 79600302
Irritability 19.26 11.00 21 123012 41123 79580232
Abdominal distension 19.24 11.00 275 122758 119375 79501980
Diaphragmatic paralysis 19.24 11.00 15 123018 1097 79620258
Colitis 19.19 11.00 54 122979 73253 79548102
Hypocoagulable state 19.18 11.00 20 123013 2139 79619216
Live birth 19.12 11.00 3 123030 18741 79602614
Electrocardiogram P wave abnormal 19.05 11.00 10 123023 366 79620989
Injection site mass 18.94 11.00 4 123029 20180 79601175
Conjunctivitis 18.87 11.00 8 123025 25707 79595648
Hypoxic-ischaemic encephalopathy 18.83 11.00 39 122994 7781 79613574
Oral pain 18.80 11.00 13 123020 31785 79589570
Orchitis 18.80 11.00 16 123017 1325 79620030
Conjunctival haemorrhage 18.75 11.00 33 123000 5832 79615523
Withdrawal syndrome 18.69 11.00 9 123024 26845 79594510
Vascular pseudoaneurysm 18.66 11.00 25 123008 3485 79617870
Musculoskeletal disorder 18.65 11.00 5 123028 21443 79599912
Rash pruritic 18.58 11.00 53 122980 71576 79549779
Aortic valve stenosis 18.52 11.00 31 123002 5263 79616092
Injection site haemorrhage 18.42 11.00 10 123023 27860 79593495
Sopor 18.41 11.00 100 122933 32910 79588445
Respiratory disorder neonatal 18.38 11.00 6 123027 62 79621293
Sepsis 18.37 11.00 545 122488 268883 79352472
Neuropathy peripheral 18.34 11.00 135 122898 141170 79480185
Diffuse vasculitis 18.34 11.00 7 123026 118 79621237
Amaurosis 18.33 11.00 15 123018 1176 79620179
Subarachnoid haematoma 18.32 11.00 9 123024 286 79621069
Dysgeusia 18.22 11.00 38 122995 57139 79564216
Blood cholesterol increased 18.20 11.00 67 122966 83653 79537702
Pseudolymphoma 18.18 11.00 15 123018 1190 79620165
Concomitant disease aggravated 18.14 11.00 53 122980 13114 79608241
Sleep disorder therapy 18.13 11.00 14 123019 1010 79620345
Pain in jaw 18.03 11.00 27 123006 46124 79575231
Feeling cold 18.00 11.00 11 123022 28718 79592637
Normocytic anaemia 17.98 11.00 27 123006 4180 79617175
Paranoia 17.93 11.00 4 123029 19428 79601927
Bone erosion 17.89 11.00 3 123030 17844 79603511
Blood glucose increased 17.88 11.00 104 122929 114871 79506484
Burning sensation 17.83 11.00 40 122993 58592 79562763
Localised infection 17.78 11.00 19 123014 37556 79583799
Anxiety 17.74 11.00 273 122760 248239 79373116
Lung opacity 17.70 11.00 30 123003 5144 79616211
Thyroxine free decreased 17.62 11.00 14 123019 1053 79620302
Frequent bowel movements 17.57 11.00 12 123021 29527 79591828
Bone disorder 17.50 11.00 4 123029 19109 79602246
Unevaluable event 17.46 11.00 146 122887 55439 79565916
Lung consolidation 17.44 11.00 41 122992 8906 79612449
Heart transplant 17.43 11.00 16 123017 1465 79619890
Arteriosclerotic retinopathy 17.42 11.00 5 123028 32 79621323
Paraesthesia oral 17.37 11.00 5 123028 20466 79600889
Hepatotoxicity 17.27 11.00 137 122896 51215 79570140
Drug reaction with eosinophilia and systemic symptoms 17.22 11.00 163 122870 64081 79557274
Crying 17.18 11.00 7 123026 23036 79598319
Dyspepsia 17.07 11.00 98 122935 108589 79512766
Throat tightness 17.05 11.00 11 123022 27896 79593459
Atrioventricular dissociation 16.96 11.00 9 123024 337 79621018
Intentional self-injury 16.96 11.00 15 123018 32404 79588951
Medication error 16.85 11.00 171 122862 68471 79552884
Reduced facial expression 16.74 11.00 21 123012 2744 79618611
Eye pain 16.70 11.00 20 123013 37558 79583797
Non-compaction cardiomyopathy 16.57 11.00 5 123028 39 79621316
Scrotal oedema 16.50 11.00 16 123017 1569 79619786
Uveitis 16.49 11.00 3 123030 16827 79604528
Cardiorenal syndrome 16.47 11.00 16 123017 1573 79619782
Ventricular hypokinesia 16.46 11.00 41 122992 9238 79612117
Tracheal compression 16.43 11.00 3 123030 0 79621355
Endovenous ablation 16.43 11.00 3 123030 0 79621355
Congestive hepatopathy 16.41 11.00 27 123006 4520 79616835
Anti-thyroid antibody positive 16.37 11.00 10 123023 491 79620864
Hyperglycaemia 16.15 11.00 55 122978 70280 79551075
Pulmonary embolism 16.14 11.00 178 122855 171476 79449879
Toxic epidermal necrolysis 16.14 11.00 121 122912 44460 79576895
Electrocardiogram RR interval prolonged 16.14 11.00 4 123029 13 79621342
Ocular hyperaemia 16.06 11.00 12 123021 28194 79593161
Transplant rejection 16.03 11.00 5 123028 19432 79601923
Splenic injury 16.00 11.00 8 123025 264 79621091
Prescribed overdose 15.96 11.00 21 123012 37862 79583493
Lip swelling 15.92 11.00 24 123009 40887 79580468
Blood uric acid increased 15.82 11.00 51 122982 13309 79608046
Weight decreased 15.81 11.00 422 122611 354776 79266579
Mental disorder 15.76 11.00 15 123018 31287 79590068
Contusion 15.75 11.00 150 122883 148626 79472729
Toxic nodular goitre 15.74 11.00 5 123028 47 79621308
Grip strength decreased 15.73 11.00 7 123026 21862 79599493
Inferior vena cava syndrome 15.72 11.00 6 123027 101 79621254
Systemic inflammatory response syndrome 15.66 11.00 46 122987 11419 79609936
Local anaesthetic systemic toxicity 15.65 11.00 13 123020 1041 79620314
Blood pressure systolic increased 15.64 11.00 52 122981 66934 79554421
Swollen tongue 15.59 11.00 26 123007 42544 79578811
Hypovolaemic shock 15.58 11.00 48 122985 12228 79609127
Pericarditis fungal 15.58 11.00 7 123026 181 79621174
Paroxysmal arrhythmia 15.56 11.00 5 123028 49 79621306
Liver scan abnormal 15.56 11.00 5 123028 49 79621306
Inappropriate antidiuretic hormone secretion 15.56 11.00 81 122952 26232 79595123
Haemorrhagic thyroid cyst 15.49 11.00 4 123029 16 79621339
Traumatic haemothorax 15.45 11.00 10 123023 544 79620811
Crepitations 15.45 11.00 42 122991 9975 79611380
Brain natriuretic peptide increased 15.45 11.00 39 122994 8861 79612494
Eye swelling 15.41 11.00 11 123022 26457 79594898
Hepatic cyst 15.41 11.00 31 123002 6058 79615297
Malaise 15.37 11.00 609 122424 489260 79132095
Diabetic ketoacidosis 15.33 11.00 18 123015 34104 79587251
Pulmonary arterial hypertension 15.20 11.00 85 122948 28281 79593074
Therapy non-responder 15.16 11.00 82 122951 92223 79529132
Tooth disorder 15.15 11.00 11 123022 26222 79595133
Serotonin syndrome 15.14 11.00 29 123004 44998 79576357
Sinus arrest 15.13 11.00 23 123010 3599 79617756
Anticoagulation drug level below therapeutic 15.07 11.00 15 123018 1518 79619837
Dry eye 15.02 11.00 21 123012 36910 79584445
Bronchitis 15.01 11.00 129 122904 130515 79490840
Rash maculo-papular 14.89 11.00 142 122891 55936 79565419
Vascular graft 14.88 11.00 17 123016 2014 79619341
Lymphadenopathy 14.86 11.00 38 122995 53209 79568146
Device dislocation 14.85 11.00 11 123022 25959 79595396
Device issue 14.84 11.00 12 123021 27096 79594259
Treatment noncompliance 14.82 11.00 37 122996 52231 79569124
Ventricular remodelling 14.82 11.00 6 123027 119 79621236
Coagulation test abnormal 14.80 11.00 14 123019 1331 79620024
Road traffic accident 14.79 11.00 28 123005 43636 79577719
Alveolitis necrotising 14.77 11.00 4 123029 20 79621335
Tenosynovitis 14.76 11.00 3 123030 15551 79605804
Subdural haemorrhage 14.71 11.00 30 123003 5918 79615437
Haematotoxicity 14.71 11.00 3 123030 15516 79605839
Vascular stent thrombosis 14.71 11.00 23 123010 3687 79617668
Sneezing 14.64 11.00 6 123027 19677 79601678
Impaired work ability 14.64 11.00 6 123027 19675 79601680
Red blood cell sedimentation rate abnormal 14.63 11.00 7 123026 20956 79600399
Liver function test abnormal 14.59 11.00 158 122875 64317 79557038
Electrocardiogram T wave abnormal 14.59 11.00 23 123010 3715 79617640
Aphthous ulcer 14.56 11.00 4 123029 16885 79604470
Agranulocytosis 14.53 11.00 119 122914 44911 79576444
Faecaloma 14.48 11.00 45 122988 11519 79609836
Ventricular dysfunction 14.45 11.00 30 123003 5993 79615362
Fascial rupture 14.45 11.00 4 123029 22 79621333
Carpal tunnel syndrome 14.45 11.00 6 123027 19522 79601833
Foot fracture 14.36 11.00 8 123025 21973 79599382
Ulcer 14.36 11.00 15 123018 29957 79591398
Purpura 14.35 11.00 64 122969 19463 79601892
Hypothyroidic goitre 14.35 11.00 3 123030 3 79621352
Failure to suspend medication 14.32 11.00 9 123024 465 79620890
Thrombin time prolonged 14.28 11.00 8 123025 334 79621021
Hepatitis 14.25 11.00 140 122893 55587 79565768
Hypothermia 14.13 11.00 71 122962 22675 79598680
Mesenteric artery thrombosis 14.11 11.00 10 123023 632 79620723
Chorea 14.07 11.00 18 123015 2399 79618956
Limb discomfort 14.05 11.00 18 123015 32832 79588523
Hepatojugular reflux 14.03 11.00 10 123023 638 79620717
Hypoglycaemic seizure 14.01 11.00 11 123022 813 79620542
Amyloidosis 13.97 11.00 19 123014 2687 79618668
Dialysis 13.94 11.00 61 122972 18401 79602954
Pelvic fracture 13.92 11.00 46 122987 12158 79609197
Atrio-oesophageal fistula 13.89 11.00 3 123030 4 79621351
Bone marrow failure 13.86 11.00 37 122996 51070 79570285
Neutrophil count increased 13.76 11.00 15 123018 29381 79591974
Injection site warmth 13.76 11.00 3 123030 14804 79606551
Adrenal haematoma 13.73 11.00 6 123027 145 79621210
Oesophageal infection 13.68 11.00 10 123023 664 79620691
Tooth infection 13.59 11.00 6 123027 18826 79602529
Gastroenteritis aeromonas 13.51 11.00 4 123029 29 79621326
Laryngitis 13.46 11.00 4 123029 16035 79605320
Therapy partial responder 13.44 11.00 5 123028 17392 79603963
Hypochromasia 13.39 11.00 10 123023 686 79620669
Thyrotoxic periodic paralysis 13.36 11.00 6 123027 155 79621200
Tachypnoea 13.34 11.00 90 122943 31973 79589382
Renal function test abnormal 13.31 11.00 26 123007 4972 79616383
Splenic haemorrhage 13.26 11.00 10 123023 696 79620659
Transaminases increased 13.23 11.00 130 122903 51613 79569742
Thyroglobulin increased 13.22 11.00 5 123028 82 79621273
Diverticulum intestinal 13.19 11.00 36 122997 8569 79612786
Taste disorder 13.18 11.00 4 123029 15819 79605536
Altered visual depth perception 13.17 11.00 8 123025 389 79620966
Chest X-ray abnormal 13.12 11.00 34 122999 7849 79613506
Axonal neuropathy 13.08 11.00 16 123017 2038 79619317
Infective pericardial effusion 13.06 11.00 4 123029 33 79621322
Sleep disorder due to a general medical condition 13.05 11.00 3 123030 14274 79607081
Lymphoid tissue hyperplasia 13.05 11.00 7 123026 268 79621087
Neovascular age-related macular degeneration 13.04 11.00 8 123025 396 79620959
Foreign body 12.98 11.00 19 123014 2875 79618480
Neuroleptic malignant syndrome 12.97 11.00 14 123019 27545 79593810
Electrocardiogram QRS complex shortened 12.96 11.00 10 123023 720 79620635
Circulatory collapse 12.94 11.00 101 122932 37567 79583788
Kidney infection 12.83 11.00 9 123024 21842 79599513
Colonic haematoma 12.80 11.00 5 123028 90 79621265
Foot deformity 12.76 11.00 11 123022 24063 79597292
Electrocardiogram low voltage 12.75 11.00 4 123029 36 79621319
Oesophageal adenocarcinoma recurrent 12.75 11.00 4 123029 36 79621319
Sinus arrhythmia 12.73 11.00 16 123017 2094 79619261
Obstructive airways disorder 12.69 11.00 18 123015 31441 79589914
Hypernatraemia 12.68 11.00 50 122983 14401 79606954
Upper gastrointestinal haemorrhage 12.63 11.00 108 122925 41272 79580083
Leukopenia 12.53 11.00 117 122916 116396 79504959
Generalised tonic-clonic seizure 12.52 11.00 31 123002 43879 79577476
Cyst 12.47 11.00 3 123030 13837 79607518
Wolff-Parkinson-White syndrome 12.41 11.00 7 123026 296 79621059
Microcytic anaemia 12.34 11.00 26 123007 5248 79616107
Drug clearance decreased 12.34 11.00 20 123013 3307 79618048
Oedema genital 12.32 11.00 9 123024 597 79620758
Kounis syndrome 12.30 11.00 23 123010 4259 79617096
Intervertebral disc protrusion 12.27 11.00 11 123022 23610 79597745
Thrombotic microangiopathy 12.25 11.00 8 123025 20161 79601194
Angioedema 12.24 11.00 68 122965 75967 79545388
Oesophageal achalasia 12.22 11.00 10 123023 784 79620571
Metabolic acidosis 12.21 11.00 187 122846 82342 79539013
Optic atrophy 12.21 11.00 15 123018 1918 79619437
Therapeutic drug monitoring analysis not performed 12.20 11.00 15 123018 1921 79619434
Hyperphosphataemia 12.19 11.00 29 123004 6347 79615008
Pulmonary haemorrhage 12.18 11.00 50 122983 14667 79606688
Graft versus host disease 12.16 11.00 4 123029 15022 79606333
Secretion discharge 12.15 11.00 4 123029 15018 79606337
Coagulation time prolonged 12.10 11.00 17 123016 2478 79618877
Prerenal failure 12.07 11.00 21 123012 3677 79617678
Haemoperitoneum 12.07 11.00 23 123010 4320 79617035
Dissociation 12.05 11.00 22 123011 3999 79617356
Blood cyanide increased 12.03 11.00 4 123029 44 79621311
Toothache 12.03 11.00 8 123025 19962 79601393
Abdominal pain lower 12.03 11.00 19 123014 31763 79589592
Electrocardiogram T wave inversion 12.01 11.00 26 123007 5346 79616009
Product storage error 11.98 11.00 5 123028 16221 79605134
Ventricular flutter 11.96 11.00 5 123028 108 79621247
Wrong technique in product usage process 11.93 11.00 66 122967 73809 79547546
Blood triglycerides increased 11.92 11.00 9 123024 21031 79600324
Demyelinating polyneuropathy 11.90 11.00 14 123019 1712 79619643
Iron deficiency anaemia 11.87 11.00 74 122959 25598 79595757
Linear IgA disease 11.85 11.00 19 123014 3113 79618242
Thirst 11.85 11.00 7 123026 18612 79602743
Eosinophilia myalgia syndrome 11.82 11.00 3 123030 11 79621344
Intestinal obstruction 11.78 11.00 31 123002 42989 79578366
Tubulointerstitial nephritis 11.78 11.00 100 122933 38135 79583220
Hospitalisation 11.76 11.00 91 122942 94145 79527210
Panic attack 11.74 11.00 12 123021 24204 79597151
Hyperthermia 11.70 11.00 57 122976 17980 79603375
Cardiac dysfunction 11.66 11.00 22 123011 4102 79617253
Extradural haematoma 11.64 11.00 18 123015 2858 79618497
Therapy interrupted 11.61 11.00 19 123014 31322 79590033
Nodule 11.60 11.00 11 123022 22983 79598372
Dilatation ventricular 11.58 11.00 22 123011 4122 79617233
Wound dehiscence 11.55 11.00 29 123004 6566 79614789
Flatulence 11.54 11.00 31 123002 42693 79578662
Bladder cancer 11.52 11.00 8 123025 19518 79601837
Cardiomyopathy 11.51 11.00 80 122953 28694 79592661
Nephroangiosclerosis 11.49 11.00 7 123026 342 79621013
Adverse drug reaction 11.45 11.00 58 122975 66334 79555021
Intervertebral disc degeneration 11.44 11.00 5 123028 15780 79605575
Body temperature decreased 11.44 11.00 20 123013 32125 79589230
Postrenal failure 11.43 11.00 9 123024 668 79620687
Oesophageal squamous cell carcinoma 11.40 11.00 8 123025 498 79620857
Eye pruritus 11.40 11.00 9 123024 20561 79600794
Impaired quality of life 11.34 11.00 4 123029 14382 79606973
Gait disturbance 11.31 11.00 239 122794 207267 79414088
Encephalopathy 11.27 11.00 156 122877 67241 79554114
Petechiae 11.27 11.00 62 122971 20503 79600852
Fasting 11.22 11.00 4 123029 55 79621300
Acute myocardial infarction 11.19 11.00 174 122859 76862 79544493
Hepatic cytolysis 11.17 11.00 76 122957 27075 79594280
Tenderness 11.14 11.00 12 123021 23630 79597725
Electrocardiogram U wave present 11.10 11.00 5 123028 130 79621225
Fibrosis 11.09 11.00 25 123008 5284 79616071
Septic rash 11.08 11.00 3 123030 15 79621340
Sinus disorder 11.04 11.00 11 123022 22453 79598902
Hypertriglyceridaemia 11.02 11.00 3 123030 12737 79608618

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac arrest neonatal 41.28 40.06 11 86 83 89612

Pharmacologic Action:

SourceCodeDescription
ATC C01BD01 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
ANTIARRHYTHMICS, CLASS I AND III
Antiarrhythmics, class III
FDA EPC N0000175426 Antiarrhythmic
CHEBI has role CHEBI:35554 cardiovascular agent
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D065609 Cytochrome P-450 CYP1A2 Inhibitors
MeSH PA D065688 Cytochrome P-450 CYP2C9 Inhibitors
MeSH PA D065690 Cytochrome P-450 CYP2D6 Inhibitors
MeSH PA D065692 Cytochrome P-450 CYP3A Inhibitors
MeSH PA D065607 Cytochrome P-450 Enzyme Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
MeSH PA D026902 Potassium Channel Blockers
MeSH PA D026941 Sodium Channel Blockers
MeSH PA D014665 Vasodilator Agents
FDA MoA N0000182137 Cytochrome P450 2D6 Inhibitors
FDA MoA N0000182138 Cytochrome P450 1A2 Inhibitors
FDA MoA N0000182141 Cytochrome P450 3A4 Inhibitors
FDA MoA N0000185503 P-Glycoprotein Inhibitors
FDA MoA N0000185504 Cytochrome P450 2C9 Inhibitors
FDA MoA N0000190114 Cytochrome P450 3A Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ventricular fibrillation indication 71908006
Prevention of Ventricular Fibrillation indication
Life-Threatening Ventricular Tachycardia indication
Atrial fibrillation off-label use 49436004 DOID:0060224
Cardioversion of Atrial Fibrillation off-label use
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation off-label use
Complete atrioventricular block contraindication 27885002
Torsades de pointes contraindication 31722008
Hyperthyroidism contraindication 34486009 DOID:7998
Extrinsic allergic alveolitis contraindication 37471005 DOID:841
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Refractive keratoplasty by laser surgery contraindication 58076004
Sinus node dysfunction contraindication 60423000
Interstitial pneumonia contraindication 64667001
Optic neuritis contraindication 66760008 DOID:1210
Corneal deposit contraindication 74460005 DOID:11547
Disorder of optic nerve contraindication 77157004 DOID:1891
Pulmonary hemorrhage contraindication 78144005
Cardiogenic shock contraindication 89138009
Thyrotoxicosis contraindication 90739004 DOID:7997
Prolonged QT interval contraindication 111975006
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Second degree atrioventricular block contraindication 195042002
Disease of liver contraindication 235856003 DOID:409
Drug-induced hepatitis contraindication 235876009
Pregnancy, function contraindication 289908002
Peripheral nerve disease contraindication 302226006
Eosinophilic asthma contraindication 367542003 DOID:9498
Surgical procedure contraindication 387713003
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Congenital long QT syndrome contraindication 442917000
Syncope due to Bradycardia contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.72 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Potassium voltage-gated channel subfamily H member 2 Ion channel BLOCKER IC50 5 WOMBAT-PK CHEMBL
Sodium channel protein type 5 subunit alpha Ion channel BLOCKER IC50 7.10 WOMBAT-PK
Mu-type opioid receptor GPCR Ki 5.11 DRUG MATRIX
D(1A) dopamine receptor GPCR Ki 5.34 DRUG MATRIX
D(2) dopamine receptor GPCR Ki 5.18 DRUG MATRIX
Alpha-2A adrenergic receptor GPCR IC50 6.30 WOMBAT-PK
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 7 WOMBAT-PK
Thyroid hormone receptor alpha Nuclear hormone receptor IC50 5.64 WOMBAT-PK
Thyroid hormone receptor beta Nuclear hormone receptor IC50 6.22 WOMBAT-PK
Cytochrome P450 3A4 Enzyme Ki 6.22 WOMBAT-PK
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase Enzyme Ki 7.60 WOMBAT-PK
Multidrug resistance protein 1 Transporter Ki 5.30 WOMBAT-PK
Sodium-dependent serotonin transporter Transporter Ki 5.91 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.65 DRUG MATRIX
5-hydroxytryptamine receptor 2A GPCR Ki 5.99 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 6.23 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 6.67 DRUG MATRIX
5-hydroxytryptamine receptor 6 GPCR Ki 5.05 DRUG MATRIX
Alpha-2B adrenergic receptor GPCR Ki 5.23 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 6.39 DRUG MATRIX
Histamine H2 receptor GPCR Ki 4.98 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 6.20 DRUG MATRIX
Muscarinic acetylcholine receptor M2 GPCR Ki 5.74 DRUG MATRIX
Muscarinic acetylcholine receptor M3 GPCR Ki 6.17 DRUG MATRIX
Muscarinic acetylcholine receptor M4 GPCR Ki 6.30 DRUG MATRIX
Muscarinic acetylcholine receptor M5 GPCR Ki 5.97 DRUG MATRIX
Beta-3 adrenergic receptor GPCR Ki 4.50 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.70 DRUG MATRIX
Adenosine receptor A3 GPCR Ki 5.00 DRUG MATRIX
D(4) dopamine receptor GPCR Ki 5.21 DRUG MATRIX
Kappa-type opioid receptor GPCR Ki 5.18 DRUG MATRIX
Delta-type opioid receptor GPCR Ki 5.55 DRUG MATRIX
Cytochrome P450 2C9 Enzyme EC50 7.40 WOMBAT-PK
Voltage-dependent T-type calcium channel subunit alpha-1H Ion channel Ki 5.28 WOMBAT-PK
Endothelin-1 receptor GPCR Ki 4.79 DRUG MATRIX
Squalene monooxygenase Enzyme IC50 4.92 CHEMBL
Tyrosine-protein kinase Fyn Kinase IC50 6.09 DRUG MATRIX
Receptor tyrosine-protein kinase erbB-2 Kinase IC50 5.04 DRUG MATRIX
Squalene synthase Enzyme IC50 5.10 CHEMBL
C-C chemokine receptor type 2 GPCR Ki 5.37 DRUG MATRIX
Substance-K receptor GPCR Ki 5.19 DRUG MATRIX
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Ion channel IC50 5.35 WOMBAT-PK
Potassium voltage-gated channel subfamily A member 7 Ion channel IC50 6 WOMBAT-PK
B2 bradykinin receptor GPCR Ki 5.12 DRUG MATRIX
Melanocortin receptor 4 GPCR Ki 4.88 DRUG MATRIX
Melanocortin receptor 5 GPCR Ki 5.05 DRUG MATRIX
Melanocortin receptor 3 GPCR Ki 4.97 DRUG MATRIX
C-C chemokine receptor type 4 GPCR Ki 4.94 DRUG MATRIX
THAP domain-containing protein 1 Unclassified IC50 6.19 WOMBAT-PK
NAD-dependent deacetylase sirtuin 3 Enzyme EC50 5.49 CHEMBL
Lysine-specific demethylase PHF2 Enzyme IC50 4.08 CHEMBL
Lysine-specific demethylase 5A Enzyme IC50 4 CHEMBL
Beta-1 adrenergic receptor GPCR IC50 4.70 WOMBAT-PK
Lysine-specific demethylase 7A Enzyme IC50 4.10 CHEMBL
Androgen receptor Transcription factor Ki 4.55 DRUG MATRIX
Lethal factor Enzyme IC50 5.46 CHEMBL
5-hydroxytryptamine receptor 1B GPCR Ki 4.41 DRUG MATRIX
Membrane-associated progesterone receptor component 1 Membrane receptor IC50 6.93 DRUG MATRIX
C-8 sterol isomerase Enzyme Ki 7.21 CHEMBL
Cruzipain Enzyme IC50 5.40 CHEMBL
Sodium channel protein type 5 subunit alpha Ion channel BLOCKER IC50 5.70 IUPHAR

External reference:

IDSource
4019606 VUID
N0000147701 NUI
D00636 KEGG_DRUG
19774-82-4 SECONDARY_CAS_RN
203114 RXNORM
C0002598 UMLSCUI
CHEBI:2663 CHEBI
BBI PDB_CHEM_ID
CHEMBL633 ChEMBL_ID
CHEMBL1083993 ChEMBL_ID
D000638 MESH_DESCRIPTOR_UI
DB01118 DRUGBANK_ID
2566 IUPHAR_LIGAND_ID
2012 INN_ID
N3RQ532IUT UNII
2157 PUBCHEM_CID
13960 MMSL
4177 MMSL
d00002 MMSL
372821002 SNOMEDCT_US
52574003 SNOMEDCT_US
69236009 SNOMEDCT_US
4018065 VANDF
4019606 VANDF
000629 NDDF
004484 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9875 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 26 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9875 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 26 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0185-0144 TABLET 200 mg ORAL ANDA 27 sections
Pacerone HUMAN PRESCRIPTION DRUG LABEL 1 0245-0144 TABLET 100 mg ORAL ANDA 30 sections
Pacerone HUMAN PRESCRIPTION DRUG LABEL 1 0245-0144 TABLET 100 mg ORAL ANDA 30 sections
Pacerone HUMAN PRESCRIPTION DRUG LABEL 1 0245-0145 TABLET 400 mg ORAL ANDA 27 sections
Pacerone HUMAN PRESCRIPTION DRUG LABEL 1 0245-0145 TABLET 400 mg ORAL ANDA 27 sections
Pacerone HUMAN PRESCRIPTION DRUG LABEL 1 0245-0147 TABLET 200 mg ORAL ANDA 30 sections
Pacerone HUMAN PRESCRIPTION DRUG LABEL 1 0245-0147 TABLET 200 mg ORAL ANDA 30 sections
Pacerone HUMAN PRESCRIPTION DRUG LABEL 1 0245-1645 TABLET 400 mg ORAL ANDA 30 sections
Pacerone HUMAN PRESCRIPTION DRUG LABEL 1 0245-1645 TABLET 400 mg ORAL ANDA 30 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0404-9815 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 16 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0404-9815 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 16 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0404-9815 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 16 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8258 TABLET 200 mg ORAL ANDA 27 sections
Amiodarone hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6556 TABLET 200 mg ORAL ANDA 19 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6993 TABLET 200 mg ORAL ANDA 28 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 16714-843 TABLET 100 mg ORAL ANDA 28 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 16714-844 TABLET 200 mg ORAL ANDA 28 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 16714-845 TABLET 400 mg ORAL ANDA 28 sections
Amiodarone hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-796 TABLET 200 mg ORAL ANDA 25 sections
amiodarone hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 25021-302 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 28 sections
amiodarone hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 25021-302 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 28 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 29300-359 TABLET 200 mg ORAL ANDA 19 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 29300-359 TABLET 200 mg ORAL ANDA 19 sections
Amiodarone HCl HUMAN PRESCRIPTION DRUG LABEL 1 42494-307 TABLET 100 mg ORAL ANDA 29 sections
Amiodarone HCl HUMAN PRESCRIPTION DRUG LABEL 1 42494-307 TABLET 100 mg ORAL ANDA 29 sections
Amiodarone HCl HUMAN PRESCRIPTION DRUG LABEL 1 42494-308 TABLET 200 mg ORAL ANDA 29 sections
Amiodarone HCl HUMAN PRESCRIPTION DRUG LABEL 1 42494-308 TABLET 200 mg ORAL ANDA 29 sections
Amiodarone HCl HUMAN PRESCRIPTION DRUG LABEL 1 42494-309 TABLET 400 mg ORAL ANDA 29 sections