methylprednisolone aceponate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| prednisone and prednisolone derivatives | 1769 | 86401-95-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 0.12 mg/mL | Bocci G, Oprea TI, Benet LZ |
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Steroid withdrawal syndrome | 74.15 | 43.24 | 11 | 552 | 534 | 63487925 |
| Coagulation test abnormal | 62.63 | 43.24 | 10 | 553 | 788 | 63487671 |
| Euphoric mood | 61.34 | 43.24 | 13 | 550 | 4874 | 63483585 |
| Pelvic venous thrombosis | 61.29 | 43.24 | 11 | 552 | 1744 | 63486715 |
| Erythrodermic psoriasis | 60.20 | 43.24 | 10 | 553 | 1008 | 63487451 |
| Stupor | 51.52 | 43.24 | 11 | 552 | 4264 | 63484195 |
| Pulmonary embolism | 43.61 | 43.24 | 21 | 542 | 116663 | 63371796 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Steroid withdrawal syndrome | 39.42 | 32.88 | 6 | 437 | 240 | 34956248 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Steroid withdrawal syndrome | 67.94 | 29.50 | 11 | 925 | 710 | 79742742 |
| Coagulation test abnormal | 54.58 | 29.50 | 10 | 926 | 1335 | 79742117 |
| Erythrodermic psoriasis | 51.91 | 29.50 | 10 | 926 | 1748 | 79741704 |
| Euphoric mood | 51.73 | 29.50 | 13 | 923 | 7713 | 79735739 |
| Pelvic venous thrombosis | 49.56 | 29.50 | 10 | 926 | 2215 | 79741237 |
| Stupor | 43.21 | 29.50 | 11 | 925 | 6861 | 79736591 |
| Pulmonary embolism | 32.82 | 29.50 | 22 | 914 | 171632 | 79571820 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D07AC14 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, potent (group III) |
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175576 | Corticosteroid |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D000932 | Antiemetics |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D005765 | Gastrointestinal Agents |
| MeSH PA | D005938 | Glucocorticoids |
| MeSH PA | D006728 | Hormones |
| MeSH PA | D018696 | Neuroprotective Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D020011 | Protective Agents |
| CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
| CHEBI has role | CHEBI:35703 | Xenobiotic |
| CHEBI has role | CHEBI:37962 | adrenergic agents |
| CHEBI has role | CHEBI:50919 | antiemetico |
| CHEBI has role | CHEBI:63726 | neuroprotective agents |
| CHEBI has role | CHEBI:78298 | environmental contaminants |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.17 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D07203 | KEGG_DRUG |
| 4018068 | VANDF |
| C0174938 | UMLSCUI |
| CHEBI:135762 | CHEBI |
| CHEBI:6888 | CHEBI |
| CHEMBL1697782 | ChEMBL_ID |
| DB14643 | DRUGBANK_ID |
| C078007 | MESH_SUPPLEMENTAL_RECORD_UI |
| 5524 | INN_ID |
| ET54W9J4U2 | UNII |
| 63019 | PUBCHEM_CID |
| DB00959 | DRUGBANK_ID |
| 62136 | RXNORM |
| 1041 | MMSL |
| 5093 | MMSL |
| d00293 | MMSL |
| 002160 | NDDF |
| 006227 | NDDF |
| 116593003 | SNOMEDCT_US |
| 27242001 | SNOMEDCT_US |
| 708199003 | SNOMEDCT_US |
| C0025815 | UMLSCUI |
| 732 | INN_ID |
| 6741 | PUBCHEM_CID |
| D008775 | MESH_DESCRIPTOR_UI |
Pharmaceutical products:
None