methylprednisolone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 1768 83-43-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methylprednisolone
  • medralone
  • metilbetasone
A PREDNISOLONE derivative with similar anti-inflammatory action.
  • Molecular weight: 374.48
  • Formula: C22H30O5
  • CLOGP: 1.74
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.54
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
7.50 mg O
20 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ
S (Water solubility) 0.12 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 4.90 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 11.14 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 82 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.20 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 6.10 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.23 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.30 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Oct. 24, 1957 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 821.18 9.53 605 192476 20347 63275594
Off label use 578.67 9.53 3762 189319 670700 62625241
Glossodynia 405.53 9.53 38 193043 178838 63117103
Product use in unapproved indication 396.57 9.53 1322 191759 177758 63118183
Blood pressure fluctuation 389.33 9.53 585 192496 45732 63250209
Drug ineffective for unapproved indication 387.93 9.53 498 192583 33565 63262376
Completed suicide 374.35 9.53 16 193065 145657 63150284
Transplant rejection 340.69 9.53 274 192807 10506 63285435
Pemphigus 321.90 9.53 81 193000 183645 63112296
Abdominal discomfort 295.73 9.53 324 192757 320561 62975380
Infusion related reaction 267.70 9.53 1461 191620 244060 63051881
Alopecia 265.02 9.53 385 192696 337151 62958790
Hand deformity 261.20 9.53 80 193001 159377 63136564
Aspergillus infection 260.63 9.53 208 192873 7885 63288056
Throat irritation 257.75 9.53 433 192648 37214 63258727
Posterior reversible encephalopathy syndrome 252.05 9.53 287 192794 17058 63278883
Oxygen saturation decreased 247.94 9.53 710 192371 87875 63208066
Haemophagocytic lymphohistiocytosis 247.91 9.53 227 192854 10400 63285541
Systemic lupus erythematosus 245.78 9.53 167 192914 208751 63087190
Blood pressure diastolic abnormal 241.37 9.53 258 192823 14284 63281657
Wound 238.29 9.53 99 192982 163164 63132777
Contraindicated product administered 230.38 9.53 194 192887 217454 63078487
Blood pressure systolic abnormal 228.39 9.53 241 192840 13145 63282796
Cytomegalovirus viraemia 214.27 9.53 160 192921 5489 63290452
Multiple organ dysfunction syndrome 213.30 9.53 508 192573 56244 63239697
Swelling 209.34 9.53 321 192760 275057 63020884
Urine abnormality 204.14 9.53 170 192911 6849 63289092
Bronchopulmonary aspergillosis 202.50 9.53 185 192896 8450 63287491
Polyomavirus-associated nephropathy 202.21 9.53 103 192978 1745 63294196
Pericarditis 199.85 9.53 75 193006 131504 63164437
Discomfort 196.54 9.53 134 192947 167240 63128701
Rheumatoid factor positive 193.69 9.53 17 193064 84389 63211552
Duodenal ulcer perforation 193.68 9.53 20 193061 87189 63208752
Arthropathy 191.91 9.53 260 192821 234532 63061409
Pneumocystis jirovecii pneumonia 190.51 9.53 246 192835 16668 63279273
Synovitis 190.05 9.53 173 192908 186745 63109196
Death 187.10 9.53 553 192528 373828 62922113
Blood pressure increased 186.37 9.53 979 192102 161083 63134858
Drug intolerance 184.86 9.53 416 192665 308245 62987696
Thrombotic microangiopathy 181.71 9.53 191 192890 10370 63285571
Urine leukocyte esterase positive 181.34 9.53 121 192960 3458 63292483
Helicobacter infection 180.68 9.53 32 193049 92753 63203188
Kidney transplant rejection 177.88 9.53 128 192953 4143 63291798
Blood pressure systolic increased 174.58 9.53 421 192660 46976 63248965
BK virus infection 173.75 9.53 114 192967 3165 63292776
Toxicity to various agents 171.34 9.53 306 192775 246944 63048997
Cytomegalovirus infection reactivation 170.18 9.53 121 192960 3842 63292099
Irritable bowel syndrome 168.13 9.53 25 193056 82387 63213554
Mucormycosis 167.39 9.53 106 192975 2765 63293176
Blood pressure diastolic decreased 165.95 9.53 269 192812 22437 63273504
Lymphocyte count decreased 164.79 9.53 315 192766 29942 63265999
Klebsiella infection 160.16 9.53 162 192919 8404 63287537
Complications of transplanted kidney 153.02 9.53 95 192986 2391 63293550
Post transplant lymphoproliferative disorder 152.89 9.53 125 192956 4906 63291035
Heart rate decreased 152.32 9.53 390 192691 45170 63250771
Epstein-Barr virus infection 151.90 9.53 153 192928 7897 63288044
Muscle injury 150.36 9.53 13 193068 65332 63230609
Progressive multifocal leukoencephalopathy 149.77 9.53 191 192890 12780 63283161
Red blood cells urine positive 149.57 9.53 102 192979 3024 63292917
Nocardiosis 148.87 9.53 86 192995 1890 63294051
Product dose omission issue 148.35 9.53 306 192775 234007 63061934
Enterococcal infection 147.79 9.53 149 192932 7699 63288242
Pseudomonas infection 143.73 9.53 174 192907 11039 63284902
Confusional state 140.29 9.53 320 192761 236060 63059881
Respiratory failure 138.86 9.53 646 192435 101212 63194729
Anti-cyclic citrullinated peptide antibody positive 136.44 9.53 93 192988 116119 63179822
White blood cells urine positive 133.81 9.53 117 192964 5041 63290900
Sleep disorder due to general medical condition, insomnia type 133.21 9.53 6 193075 52211 63243730
Delayed graft function 131.59 9.53 65 193016 1028 63294913
COVID-19 129.77 9.53 683 192398 112420 63183521
Varicella zoster virus infection 129.28 9.53 88 192993 2601 63293340
Septic shock 123.23 9.53 464 192617 66165 63229776
Lymphopenia 121.72 9.53 208 192873 18119 63277822
Folliculitis 121.15 9.53 32 193049 70285 63225656
Intentional overdose 119.93 9.53 38 193043 74114 63221827
Drug ineffective 117.18 9.53 4070 189011 1040695 62255246
Cushingoid 115.88 9.53 136 192945 8349 63287592
Acinetobacter infection 114.24 9.53 67 193014 1516 63294425
Urinary sediment present 110.46 9.53 74 193007 2129 63293812
Fall 110.06 9.53 720 192361 391614 62904327
Heart rate increased 109.41 9.53 571 192510 93667 63202274
Erythema 108.03 9.53 908 192173 174843 63121098
Injection site pain 107.73 9.53 142 192939 129658 63166283
Steroid diabetes 106.80 9.53 60 193021 1248 63294693
Pneumomediastinum 104.22 9.53 61 193020 1375 63294566
Electric shock 103.59 9.53 59 193022 1261 63294680
Acute respiratory distress syndrome 103.21 9.53 224 192857 23310 63272631
Knee arthroplasty 102.72 9.53 20 193061 54186 63241755
Adverse event 100.08 9.53 40 193041 67519 63228422
Blister 99.79 9.53 150 192931 129664 63166277
Disease recurrence 98.97 9.53 245 192836 27785 63268156
Hospitalisation 98.64 9.53 69 193012 85012 63210929
Escherichia infection 98.55 9.53 155 192926 12599 63283342
Intervertebral discitis 97.66 9.53 80 193001 3148 63292793
Graft versus host disease in gastrointestinal tract 97.38 9.53 80 193001 3161 63292780
Acute graft versus host disease in skin 97.06 9.53 82 192999 3370 63292571
Fatigue 96.74 9.53 2015 191066 886013 62409928
Infective aneurysm 96.62 9.53 39 193042 370 63295571
Graft versus host disease 95.03 9.53 110 192971 6653 63289288
Premature delivery 93.84 9.53 252 192829 30029 63265912
Acute graft versus host disease in intestine 93.14 9.53 61 193020 1688 63294253
Human herpesvirus 6 infection 93.08 9.53 75 193006 2882 63293059
Blood urine present 92.24 9.53 165 192916 14904 63281037
Drug abuse 92.05 9.53 53 193028 72465 63223476
Adverse drug reaction 91.95 9.53 65 193016 79649 63216292
Pain 91.41 9.53 1645 191436 738983 62556958
Wrong technique in product usage process 90.57 9.53 38 193043 62302 63233639
Cytomegalovirus test positive 89.64 9.53 74 193007 2944 63292997
Osteonecrosis 89.36 9.53 217 192864 24313 63271628
Device expulsion 89.12 9.53 4 193077 34918 63261023
Stomatitis 88.72 9.53 180 192901 138545 63157396
Adenovirus infection 86.66 9.53 78 193003 3493 63292448
Reversible cerebral vasoconstriction syndrome 84.91 9.53 68 193013 2590 63293351
Therapeutic product effect decreased 84.75 9.53 302 192779 192885 63103056
Crystal urine present 83.99 9.53 56 193025 1598 63294343
Ear pruritus 83.45 9.53 80 193001 3885 63292056
Swollen joint count increased 83.41 9.53 7 193074 36047 63259894
Cardiac failure congestive 83.13 9.53 95 192986 92338 63203603
Diarrhoea 82.92 9.53 1606 191475 713760 62582181
Thrombocytopenia 82.02 9.53 760 192321 150397 63145544
Lupus nephritis 80.98 9.53 68 193013 2771 63293170
Candida infection 80.96 9.53 229 192852 28122 63267819
Pneumatosis intestinalis 79.80 9.53 63 193018 2350 63293591
Immunosuppressant drug level increased 79.61 9.53 75 193006 3563 63292378
Myopathy 78.28 9.53 130 192951 11061 63284880
Chorioretinopathy 78.20 9.53 42 193039 797 63295144
Sepsis 78.17 9.53 760 192321 152363 63143578
Peripheral swelling 77.58 9.53 482 192599 265460 63030481
Product use issue 77.30 9.53 376 192705 220144 63075797
Ureaplasma infection 76.26 9.53 38 193043 613 63295328
Lower respiratory tract infection 76.10 9.53 182 192899 132125 63163816
Vomiting 76.04 9.53 1221 191860 558396 62737545
Nausea 75.09 9.53 2003 191078 852468 62443473
Cytomegalovirus colitis 74.32 9.53 60 193021 2312 63293629
Fibromyalgia 74.13 9.53 81 193000 80339 63215602
Liver transplant rejection 73.87 9.53 49 193032 1386 63294555
Neutrophil count increased 73.26 9.53 158 192923 16369 63279572
Bacterial test 72.61 9.53 45 193036 1129 63294812
Strongyloidiasis 72.56 9.53 46 193035 1202 63294739
Infection reactivation 71.73 9.53 45 193036 1154 63294787
Leukopenia 71.66 9.53 441 192640 76849 63219092
Viral haemorrhagic cystitis 71.33 9.53 40 193041 829 63295112
Suicide attempt 71.14 9.53 49 193032 60869 63235072
Rebound effect 71.08 9.53 78 193003 4448 63291493
Rheumatic fever 69.87 9.53 22 193059 43089 63252852
Urine ketone body present 69.44 9.53 59 193022 2444 63293497
Systemic candida 69.30 9.53 66 193015 3179 63292762
Hip arthroplasty 69.28 9.53 29 193052 47617 63248324
Polyomavirus viraemia 69.13 9.53 37 193044 697 63295244
Pharyngeal paraesthesia 67.62 9.53 53 193028 1956 63293985
Pleocytosis 66.94 9.53 38 193043 807 63295134
COVID-19 pneumonia 66.64 9.53 139 192942 14070 63281871
Human herpesvirus 8 infection 65.80 9.53 26 193055 232 63295709
Demyelination 64.77 9.53 92 192989 6828 63289113
Gastrointestinal disorder 64.56 9.53 195 192886 131044 63164897
Drug resistance 64.28 9.53 184 192897 22749 63273192
Dehydration 64.01 9.53 290 192791 173064 63122877
Cytomegalovirus chorioretinitis 61.86 9.53 48 193033 1745 63294196
Herpes simplex 61.81 9.53 99 192982 8172 63287769
Psoriatic arthropathy 61.75 9.53 115 192966 91405 63204536
Hepatic enzyme increased 61.44 9.53 362 192719 201966 63093975
Pneumonia cytomegaloviral 61.04 9.53 52 193029 2162 63293779
Monocyte count increased 60.59 9.53 93 192988 7400 63288541
JC virus infection 60.32 9.53 50 193031 2001 63293940
Hypersensitivity 60.23 9.53 584 192497 292101 63003840
Graft versus host disease in skin 59.98 9.53 58 193023 2847 63293094
Constipation 59.38 9.53 420 192661 224523 63071418
Blood pressure diastolic increased 59.22 9.53 108 192973 9902 63286039
Status epilepticus 58.98 9.53 138 192943 15095 63280846
Disseminated intravascular coagulation 58.47 9.53 158 192923 18893 63277048
Serotonin syndrome 57.80 9.53 9 193072 28673 63267268
Decreased appetite 56.82 9.53 489 192592 250563 63045378
Accidental exposure to product 56.61 9.53 8 193073 27397 63268544
Injection site erythema 56.57 9.53 104 192977 83070 63212871
Urine analysis abnormal 56.55 9.53 73 193008 4943 63290998
Pulmonary mucormycosis 56.17 9.53 25 193056 308 63295633
Sedation 55.82 9.53 24 193057 38785 63257156
Loss of personal independence in daily activities 55.80 9.53 134 192947 97156 63198785
Red cell distribution width increased 55.37 9.53 108 192973 10416 63285525
Overdose 55.16 9.53 173 192908 114905 63181036
Vasculitis 54.87 9.53 150 192931 18059 63277882
Brain abscess 54.85 9.53 48 193033 2070 63293871
Contusion 54.80 9.53 252 192829 149792 63146149
Enterobacter infection 54.74 9.53 49 193032 2178 63293763
Rheumatoid arthritis 54.54 9.53 1079 192002 252740 63043201
Adrenal insufficiency 54.41 9.53 148 192933 17767 63278174
Granulomatosis with polyangiitis 54.03 9.53 49 193032 2216 63293725
Protein urine present 53.83 9.53 79 193002 6041 63289900
Herpes zoster 53.81 9.53 432 192649 82030 63213911
Partial seizures 53.70 9.53 77 193004 5765 63290176
Culture urine positive 53.54 9.53 61 193020 3626 63292315
Depressed level of consciousness 53.46 9.53 66 193015 62012 63233929
Lymphocyte percentage decreased 53.17 9.53 55 193026 2930 63293011
Immune thrombocytopenia 52.73 9.53 106 192975 10450 63285491
Acute graft versus host disease in liver 52.68 9.53 30 193051 641 63295300
Intensive care unit acquired weakness 52.12 9.53 32 193049 789 63295152
Mycoplasma infection 51.49 9.53 27 193054 487 63295454
Staphylococcal sepsis 51.03 9.53 90 192991 8038 63287903
Orthostatic hypotension 51 9.53 23 193058 36137 63259804
Stenotrophomonas infection 50.62 9.53 45 193036 1982 63293959
Flushing 50.43 9.53 396 192685 74691 63221250
Oedema peripheral 50.42 9.53 353 192728 189158 63106783
Rash 49.81 9.53 1312 191769 559559 62736382
Immunodeficiency 49.66 9.53 155 192926 20099 63275842
Cystitis haemorrhagic 49.64 9.53 62 193019 4061 63291880
Disseminated tuberculosis 49.58 9.53 52 193029 2815 63293126
Nephropathy toxic 49.54 9.53 97 192984 9382 63286559
Haemoglobin urine present 49.52 9.53 31 193050 792 63295149
Proteinuria 49.25 9.53 149 192932 18996 63276945
Bacterial test positive 48.85 9.53 70 193011 5237 63290704
Hypogammaglobulinaemia 48.56 9.53 82 192999 7073 63288868
Pulmonary alveolar haemorrhage 48.10 9.53 65 193016 4603 63291338
Temperature regulation disorder 48.04 9.53 75 193006 6057 63289884
Encephalitis 47.79 9.53 92 192989 8788 63287153
Drug effective for unapproved indication 47.74 9.53 55 193026 3309 63292632
Acute graft versus host disease 47.68 9.53 63 193018 4365 63291576
Dizziness 47.57 9.53 972 192109 428953 62866988
Alveolitis 47.11 9.53 51 193030 2864 63293077
General physical health deterioration 47.04 9.53 389 192692 201013 63094928
Neutrophil percentage increased 46.70 9.53 51 193030 2892 63293049
Pyrexia 46.46 9.53 1809 191272 468669 62827272
Mobility decreased 46.33 9.53 200 192881 120959 63174982
Substance-induced psychotic disorder 46.13 9.53 42 193039 1909 63294032
Product quality issue 45.81 9.53 26 193055 35839 63260102
Impaired healing 45.80 9.53 159 192922 102383 63193558
Pedal pulse abnormal 45.23 9.53 18 193063 164 63295777
Glomerulonephritis 44.92 9.53 40 193041 1766 63294175
Bacteraemia 44.62 9.53 135 192946 17213 63278728
Febrile bone marrow aplasia 44.56 9.53 80 193001 7245 63288696
Renal transplant failure 44.09 9.53 28 193053 734 63295207
Multiple sclerosis 43.61 9.53 168 192913 24204 63271737
Systemic mycosis 43.39 9.53 33 193048 1164 63294777
Staphylococcal infection 43.13 9.53 243 192838 41013 63254928
CSF oligoclonal band present 42.91 9.53 22 193059 378 63295563
Segmental diverticular colitis 42.51 9.53 17 193064 157 63295784
Post-traumatic stress disorder 42.22 9.53 65 193016 5186 63290755
Central nervous system infection 41.81 9.53 27 193054 729 63295212
Diffuse large B-cell lymphoma 41.73 9.53 74 193007 6638 63289303
Multiple-drug resistance 41.57 9.53 64 193017 5106 63290835
Chronic graft versus host disease 41.17 9.53 49 193032 3053 63292888
Pancytopenia 40.89 9.53 463 192618 96470 63199471
Intestinal perforation 40.58 9.53 103 192978 11860 63284081
Listeriosis 40.46 9.53 35 193046 1486 63294455
Immunosuppressant drug level decreased 40.42 9.53 29 193052 934 63295007
Macular degeneration 40.29 9.53 12 193069 24364 63271577
Chronic allograft nephropathy 40.26 9.53 26 193055 702 63295239
Blood calcium decreased 40.26 9.53 15 193066 26436 63269505
Mycobacterium abscessus infection 39.92 9.53 25 193056 639 63295302
Epstein-Barr virus associated lymphoproliferative disorder 39.46 9.53 38 193043 1856 63294085
Cytomegalovirus enterocolitis 39.34 9.53 25 193056 656 63295285
Calcium ionised decreased 39.07 9.53 19 193062 290 63295651
Feeding intolerance 38.81 9.53 26 193055 748 63295193
Parvovirus B19 infection 38.65 9.53 23 193058 535 63295406
Blood cholesterol increased 38.59 9.53 151 192930 93881 63202060
Therapy partial responder 38.51 9.53 94 192987 10564 63285377
Nephrotic syndrome 37.97 9.53 64 193017 5512 63290429
International normalised ratio increased 37.27 9.53 52 193029 46373 63249568
Quadriparesis 37.25 9.53 38 193043 1991 63293950
Pneumocystis jirovecii infection 37.17 9.53 33 193048 1451 63294490
Blood thyroid stimulating hormone decreased 37.16 9.53 57 193024 4533 63291408
Encephalitis autoimmune 37.13 9.53 33 193048 1453 63294488
C-reactive protein increased 37.12 9.53 446 192635 94261 63201680
Myocardial infarction 36.92 9.53 167 192914 99726 63196215
Symptom masked 36.87 9.53 25 193056 734 63295207
Herpes virus infection 36.81 9.53 63 193018 5493 63290448
Respiratory rate increased 36.80 9.53 108 192973 13540 63282401
Injection site bruising 36.68 9.53 44 193037 41866 63254075
Intra-abdominal pressure increased 36.65 9.53 17 193064 232 63295709
Necrotising herpetic retinopathy 36.64 9.53 13 193068 83 63295858
Pulmonary nocardiosis 36.47 9.53 19 193062 338 63295603
Pulmonary tuberculosis 36.44 9.53 56 193025 4461 63291480
Blood immunoglobulin A increased 36.31 9.53 25 193056 753 63295188
Malignant neoplasm progression 36.23 9.53 128 192953 81993 63213948
Hypertransaminasaemia 36.21 9.53 69 193012 6540 63289401
Coeliac disease 36.18 9.53 103 192978 12694 63283247
Encephalitis cytomegalovirus 35.96 9.53 22 193059 539 63295402
Accidental overdose 35.85 9.53 13 193068 23296 63272645
Hypoglycaemia 35.82 9.53 81 193000 59984 63235957
Nitrite urine present 35.61 9.53 28 193053 1038 63294903
Granulocyte count increased 35.58 9.53 26 193055 862 63295079
Transplant failure 35.30 9.53 33 193048 1552 63294389
Opportunistic infection 35.18 9.53 36 193045 1893 63294048
Therapy non-responder 34.98 9.53 369 192712 75532 63220409
Wheezing 34.62 9.53 161 192920 95434 63200507
Viraemia 34.44 9.53 30 193051 1286 63294655
Lung abscess 34.32 9.53 35 193046 1833 63294108
Proteus infection 34.22 9.53 28 193053 1100 63294841
Hypertension 34.21 9.53 1101 191980 278202 63017739
Drug tolerance decreased 34.06 9.53 6 193075 17467 63278474
Human bocavirus infection 33.87 9.53 19 193062 394 63295547
Intentional self-injury 33.71 9.53 18 193063 25669 63270272
Injection site swelling 33.68 9.53 58 193023 47514 63248427
Hyponatraemia 33.52 9.53 201 192880 111699 63184242
Cerebral aspergillosis 33.49 9.53 19 193062 403 63295538
Scedosporium infection 33.36 9.53 21 193060 542 63295399
Hypofibrinogenaemia 33.32 9.53 28 193053 1142 63294799
Perinephric abscess 33.06 9.53 15 193066 194 63295747
Central nervous system lymphoma 32.93 9.53 31 193050 1471 63294470
Atypical haemolytic uraemic syndrome 32.85 9.53 23 193058 712 63295229
C-reactive protein abnormal 32.82 9.53 56 193025 46040 63249901
Post cholecystectomy syndrome 32.79 9.53 19 193062 420 63295521
Hyperglycaemia 32.77 9.53 229 192852 41638 63254303
Feeling hot 32.41 9.53 263 192818 50091 63245850
Urinary tract candidiasis 32.29 9.53 21 193060 574 63295367
Memory impairment 31.91 9.53 186 192895 104072 63191869
Pregnancy 31.89 9.53 39 193042 36797 63259144
Cough 31.81 9.53 1138 191943 291605 63004336
Epstein-Barr virus infection reactivation 31.15 9.53 23 193058 775 63295166
Sedation complication 31.12 9.53 3 193078 13819 63282122
Multiple sclerosis relapse 31.09 9.53 253 192828 48225 63247716
Inappropriate schedule of product administration 31.01 9.53 187 192894 103778 63192163
Sleep disorder 30.96 9.53 135 192946 81431 63214510
Device dislocation 30.92 9.53 20 193061 25685 63270256
Aphthous ulcer 30.85 9.53 103 192978 13835 63282106
Gastroenteritis rotavirus 30.67 9.53 13 193068 141 63295800
Red blood cell sedimentation rate abnormal 30.48 9.53 11 193070 19771 63276170
Diabetes mellitus 30.43 9.53 281 192800 55529 63240412
Graft versus host disease in liver 30.40 9.53 21 193060 636 63295305
Cerebrovascular accident 30.31 9.53 198 192883 107826 63188115
Cytomegalovirus gastrointestinal infection 30.25 9.53 16 193065 294 63295647
Aspartate aminotransferase 30.24 9.53 18 193063 419 63295522
Dermatomyositis 29.87 9.53 40 193041 2808 63293133
Bacillus infection 29.79 9.53 23 193058 830 63295111
Escherichia urinary tract infection 29.75 9.53 92 192989 11870 63284071
Incorrect dose administered 29.55 9.53 89 192992 59879 63236062
Chest discomfort 29.40 9.53 484 192597 109485 63186456
Cytokine release syndrome 29.25 9.53 103 192978 14211 63281730
Temperature intolerance 29.19 9.53 76 193005 8888 63287053
Drug-induced liver injury 29.17 9.53 216 192865 40006 63255935
Full blood count abnormal 29.16 9.53 32 193049 31685 63264256
Aplasia 29.15 9.53 49 193032 4210 63291731
Device malfunction 29.14 9.53 9 193072 17848 63278093
West Nile viral infection 29.01 9.53 17 193064 384 63295557
Optic neuritis 29.00 9.53 73 193008 8362 63287579
Renal vein thrombosis 28.97 9.53 17 193064 385 63295556
Rhabdomyolysis 28.96 9.53 56 193025 43895 63252046
Joint swelling 28.86 9.53 767 192314 326899 62969042
Scleroderma renal crisis 28.86 9.53 16 193065 324 63295617
Smear cervix abnormal 28.81 9.53 40 193041 2906 63293035
B-lymphocyte count decreased 28.75 9.53 25 193056 1069 63294872
Prescribed overdose 28.69 9.53 37 193044 34116 63261825
Thunderclap headache 28.59 9.53 14 193067 217 63295724
Necrotising retinitis 28.59 9.53 17 193064 395 63295546
Chronic graft versus host disease in liver 28.49 9.53 15 193066 273 63295668
Red blood cells urine 28.38 9.53 19 193062 546 63295395
Incorrect route of product administration 28.35 9.53 25 193056 27427 63268514
Cytomegalovirus enteritis 28.34 9.53 15 193066 276 63295665
Central obesity 28.32 9.53 26 193055 1195 63294746
Gastrooesophageal reflux disease 28.01 9.53 173 192908 95466 63200475
Gastroenteritis norovirus 28.00 9.53 33 193048 2035 63293906
Obstructive airways disorder 27.91 9.53 14 193067 20685 63275256
Hyperammonaemia 27.90 9.53 54 193027 5178 63290763
Pyelonephritis fungal 27.85 9.53 12 193069 136 63295805
Chronic graft versus host disease in skin 27.83 9.53 21 193060 732 63295209
Neuropsychiatric lupus 27.73 9.53 13 193068 182 63295759
Lower limb fracture 27.59 9.53 20 193061 24201 63271740
Hepatic infarction 27.45 9.53 20 193061 660 63295281
Malignant catatonia 27.42 9.53 13 193068 187 63295754
Pyelonephritis 27.40 9.53 117 192964 17661 63278280
Shock haemorrhagic 27.35 9.53 79 193002 9816 63286125
Underdose 27.17 9.53 26 193055 27430 63268511
Q fever 27.17 9.53 12 193069 145 63295796
Hypophagia 27.16 9.53 33 193048 31226 63264715
Specific gravity urine decreased 27.12 9.53 21 193060 761 63295180
Central nervous system viral infection 27.10 9.53 11 193070 106 63295835
Laryngeal stenosis 27.06 9.53 24 193057 1054 63294887
Toxoplasmosis 27.01 9.53 28 193053 1495 63294446
Pneumonia klebsiella 26.95 9.53 35 193046 2384 63293557
Liver injury 26.91 9.53 94 192987 60426 63235515
Oral pruritus 26.86 9.53 34 193047 2257 63293684
Food allergy 26.80 9.53 86 192995 11315 63284626
Rhinocerebral mucormycosis 26.69 9.53 17 193064 448 63295493
Glomerular filtration rate increased 26.63 9.53 22 193059 876 63295065
Cataract 26.59 9.53 278 192803 56775 63239166
Rhodococcus infection 26.57 9.53 11 193070 112 63295829
Infection 26.53 9.53 514 192567 228659 63067282
Quadriplegia 26.51 9.53 30 193051 1770 63294171
Hepatosplenomegaly 26.33 9.53 36 193045 2578 63293363
Aspergillosis oral 26.27 9.53 9 193072 51 63295890
Glomerulosclerosis 26.26 9.53 16 193065 389 63295552
Meningoencephalitis viral 26.24 9.53 15 193066 323 63295618
Oral herpes 26.22 9.53 152 192929 25922 63270019
Clostridium difficile colitis 26.21 9.53 128 192953 20441 63275500
Cerebral artery stenosis 26.19 9.53 17 193064 463 63295478
Diffuse alveolar damage 26.19 9.53 22 193059 897 63295044
Factor XIII deficiency 26.15 9.53 10 193071 81 63295860
Device difficult to use 25.82 9.53 4 193077 12792 63283149
Poor venous access 25.71 9.53 101 192980 14684 63281257
Red blood cell count increased 25.69 9.53 39 193042 3073 63292868
Mitochondrial DNA mutation 25.65 9.53 16 193065 406 63295535
Candida sepsis 25.62 9.53 26 193055 1354 63294587
Pulmonary haemorrhage 25.59 9.53 63 193018 7118 63288823
Secondary immunodeficiency 25.57 9.53 26 193055 1357 63294584
Finger deformity 25.56 9.53 66 193015 7679 63288262
Anti-thyroid antibody positive 25.38 9.53 16 193065 414 63295527
Oedema 25.37 9.53 183 192898 97439 63198502
Device issue 25.36 9.53 21 193060 23760 63272181
Malacoplakia vesicae 25.30 9.53 9 193072 58 63295883
Myasthenia gravis crisis 25.20 9.53 17 193064 495 63295446
Injection site pruritus 25.18 9.53 63 193018 45053 63250888
Band sensation 25.09 9.53 21 193060 852 63295089
Bacterial sepsis 25.07 9.53 44 193037 3914 63292027
Urinary tract infection bacterial 25.07 9.53 51 193030 5071 63290870
Bronchiolitis obliterans syndrome 25.05 9.53 11 193070 131 63295810
Malacoplakia gastrointestinal 25.04 9.53 9 193072 60 63295881
Peritonitis 24.99 9.53 111 192970 17043 63278898
Malaise 24.93 9.53 1023 192058 414931 62881010
Lip dry 24.88 9.53 8 193073 15462 63280479
Thyroxine free increased 24.86 9.53 21 193060 863 63295078
Pyomyositis 24.79 9.53 15 193066 360 63295581
Hepatic necrosis 24.78 9.53 54 193027 5633 63290308
Rubella antibody positive 24.66 9.53 9 193072 63 63295878
Pneumonia bacterial 24.66 9.53 74 193007 9391 63286550
Bacterial vulvovaginitis 24.65 9.53 20 193061 776 63295165
Psoriasis 24.59 9.53 159 192922 86798 63209143
Haemoglobin urine 24.47 9.53 11 193070 139 63295802
Focal segmental glomerulosclerosis 24.28 9.53 26 193055 1442 63294499
Sinusitis 24.25 9.53 515 192566 226138 63069803
Full blood count decreased 24.21 9.53 26 193055 25998 63269943
Rheumatoid factor increased 24.20 9.53 29 193052 1820 63294121
Sleep disorder due to a general medical condition 24.16 9.53 4 193077 12184 63283757
Unresponsive to stimuli 24.15 9.53 41 193040 33775 63262166
Angiosarcoma metastatic 24.08 9.53 9 193072 68 63295873
Meningomyelitis herpes 24.01 9.53 8 193073 41 63295900
Interstitial lung disease 24.01 9.53 291 192790 61617 63234324
Corynebacterium infection 23.84 9.53 17 193064 542 63295399
Serum sickness 23.84 9.53 36 193045 2824 63293117
Pathogen resistance 23.73 9.53 57 193024 6341 63289600
Cryptococcosis 23.70 9.53 23 193058 1134 63294807
Complication associated with device 23.63 9.53 11 193070 16967 63278974
Intentional product misuse 23.62 9.53 100 192981 60817 63235124
Staphylococcal bacteraemia 23.52 9.53 52 193029 5478 63290463
Body temperature decreased 23.48 9.53 123 192958 20196 63275745
White blood cell count increased 23.28 9.53 238 192843 48323 63247618
Kaposi's sarcoma 23.28 9.53 11 193070 157 63295784
Gastropleural fistula 23.25 9.53 8 193073 46 63295895
Muir-Torre syndrome 23.25 9.53 7 193074 24 63295917
Klebsiella test positive 23.20 9.53 23 193058 1164 63294777
Joint tuberculosis 23.00 9.53 10 193071 116 63295825
Renal tubular atrophy 22.99 9.53 19 193062 757 63295184
Cervicitis 22.95 9.53 16 193065 492 63295449
Lethargy 22.93 9.53 90 192991 55917 63240024
Renal impairment 22.92 9.53 387 192694 87968 63207973
Meningoencephalitis bacterial 22.91 9.53 9 193072 79 63295862
Leukoencephalopathy 22.87 9.53 45 193036 4368 63291573
Pneumatosis 22.75 9.53 15 193066 420 63295521
Faecal volume decreased 22.73 9.53 11 193070 166 63295775
Cerebellar stroke 22.69 9.53 13 193068 281 63295660
Abdominal pain upper 22.69 9.53 467 192614 205977 63089964
Disseminated varicella zoster vaccine virus infection 22.69 9.53 8 193073 50 63295891
Hepatic cirrhosis 22.69 9.53 25 193056 24709 63271232
Gastrointestinal mucormycosis 22.61 9.53 12 193069 222 63295719
CSF protein increased 22.58 9.53 16 193065 505 63295436
Cytomegalovirus hepatitis 22.56 9.53 14 193067 352 63295589
Epstein-Barr viraemia 22.44 9.53 21 193060 989 63294952
Hepatitis B 22.39 9.53 41 193040 3771 63292170
Blood potassium increased 22.36 9.53 14 193067 18295 63277646
Escherichia sepsis 22.34 9.53 48 193033 4959 63290982
Sense of oppression 22.34 9.53 21 193060 995 63294946
Tuberculosis gastrointestinal 22.32 9.53 14 193067 359 63295582
Ultrasound ovary abnormal 22.06 9.53 9 193072 88 63295853
Neuromyelitis optica spectrum disorder 22.02 9.53 21 193060 1013 63294928
Ureteric stenosis 22.00 9.53 17 193064 614 63295327
Interleukin-2 receptor increased 21.97 9.53 9 193072 89 63295852
Steroid withdrawal syndrome 21.94 9.53 16 193065 529 63295412
Facet joint syndrome 21.92 9.53 5 193076 12133 63283808
Systemic inflammatory response syndrome 21.84 9.53 51 193030 5570 63290371
CSF measles antibody positive 21.80 9.53 8 193073 57 63295884
Myelitis 21.72 9.53 24 193057 1379 63294562
Autoimmune hepatitis 21.67 9.53 66 193015 8444 63287497
Treatment failure 21.66 9.53 451 192630 198592 63097349
Lip pruritus 21.64 9.53 20 193061 927 63295014
Acute respiratory failure 21.59 9.53 179 192902 34306 63261635
Biloma 21.57 9.53 8 193073 59 63295882
Haemolytic uraemic syndrome 21.57 9.53 32 193049 2471 63293470
Choroiditis 21.56 9.53 11 193070 187 63295754
Natural killer-cell leukaemia 21.54 9.53 9 193072 94 63295847
Breast cancer stage III 21.53 9.53 3 193078 10383 63285558
Tuberculosis 21.48 9.53 79 193002 11132 63284809
Blood pressure systolic decreased 21.36 9.53 60 193021 7337 63288604
Exostosis 21.34 9.53 14 193067 17848 63278093
Immunosuppression 21.19 9.53 67 193014 8747 63287194
Papilloma viral infection 21.17 9.53 25 193056 1545 63294396
Liver abscess 21.11 9.53 34 193047 2820 63293121
Osteomyelitis fungal 21.04 9.53 6 193075 16 63295925
Adjustment disorder with depressed mood 21.03 9.53 3 193078 10201 63285740
Birdshot chorioretinopathy 21.01 9.53 8 193073 64 63295877
Suspected COVID-19 21 9.53 32 193049 2530 63293411
Blood immunoglobulin M decreased 20.92 9.53 20 193061 968 63294973
Loss of consciousness 20.89 9.53 244 192837 117877 63178064
Hepatic cyst infection 20.81 9.53 9 193072 103 63295838
Unevaluable event 20.77 9.53 83 192998 51303 63244638
Swollen tongue 20.69 9.53 47 193034 34753 63261188
Engraftment syndrome 20.64 9.53 15 193066 493 63295448
Urine leukocyte esterase 20.60 9.53 10 193071 152 63295789
Throat tightness 20.59 9.53 138 192943 24749 63271192
Haemorrhagic varicella syndrome 20.54 9.53 5 193076 5 63295936
Renal tubular necrosis 20.54 9.53 81 193000 11797 63284144
Monoparesis 20.45 9.53 25 193056 1602 63294339
Gamma-glutamyltransferase increased 20.43 9.53 175 192906 33856 63262085
Product storage error 20.34 9.53 10 193071 14946 63280995
Osteoporosis 20.31 9.53 265 192816 57073 63238868
Butterfly rash 20.30 9.53 26 193055 1747 63294194
Neurological decompensation 20.30 9.53 32 193049 2606 63293335
Thrombocytopenic purpura 20.18 9.53 23 193058 1368 63294573
Monocyte percentage increased 20.17 9.53 21 193060 1127 63294814
Dural arteriovenous fistula 20.05 9.53 6 193075 20 63295921
Type 2 diabetes mellitus 20.04 9.53 113 192968 63755 63232186
Aeromonas infection 20.00 9.53 8 193073 74 63295867
Large intestine perforation 19.96 9.53 64 193017 8418 63287523
Haemolytic anaemia 19.95 9.53 72 193009 10053 63285888
Chronic graft versus host disease in eye 19.86 9.53 9 193072 116 63295825
Coronary artery disease 19.85 9.53 43 193038 32334 63263607
Graft loss 19.84 9.53 13 193068 360 63295581
Rash erythematous 19.74 9.53 207 192874 42303 63253638
Malacoplakia 19.60 9.53 10 193071 170 63295771
Bone marrow failure 19.40 9.53 154 192927 29136 63266805
Herpes simplex oesophagitis 19.34 9.53 10 193071 175 63295766
Hypertriglyceridaemia 19.30 9.53 52 193029 6207 63289734
Sputum discoloured 19.28 9.53 13 193068 16334 63279607
Band neutrophil percentage increased 19.23 9.53 11 193070 237 63295704
Coordination abnormal 19.22 9.53 88 192993 13685 63282256
Bronchostenosis 19.16 9.53 14 193067 464 63295477
Growth retardation 19.16 9.53 22 193059 1319 63294622
Pneumonia lipoid 19.14 9.53 9 193072 127 63295814
Blood creatinine decreased 19.08 9.53 48 193033 5497 63290444
Mean cell haemoglobin decreased 19.06 9.53 46 193035 5133 63290808
Type I hypersensitivity 19.02 9.53 33 193048 2909 63293032
Microangiopathy 19 9.53 21 193060 1207 63294734
Tri-iodothyronine free decreased 18.98 9.53 12 193069 312 63295629
Lichen sclerosus 18.97 9.53 20 193061 1089 63294852
Trichodysplasia spinulosa 18.94 9.53 15 193066 562 63295379
Tachycardia 18.93 9.53 482 192599 117674 63178267
Acute myeloid leukaemia recurrent 18.89 9.53 24 193057 1599 63294342
Poisoning 18.88 9.53 9 193072 13691 63282250
Drug level decreased 18.86 9.53 60 193021 7859 63288082
Hypotension 18.74 9.53 1011 192070 271593 63024348
Serum ferritin increased 18.70 9.53 51 193030 6131 63289810
Urine oxalate increased 18.67 9.53 11 193070 251 63295690
Product prescribing error 18.65 9.53 32 193049 26257 63269684
Intracranial infection 18.65 9.53 6 193075 27 63295914
Listeria encephalitis 18.60 9.53 11 193070 253 63295688
Cerebral venous thrombosis 18.57 9.53 27 193054 2047 63293894
Blood brain barrier defect 18.54 9.53 8 193073 91 63295850
Sebaceous carcinoma 18.47 9.53 6 193075 28 63295913
Osteoarthritis 18.42 9.53 193 192888 95150 63200791
Rheumatoid factor 18.39 9.53 12 193069 330 63295611
IgA nephropathy 18.32 9.53 15 193066 590 63295351
Chorioretinitis 18.32 9.53 15 193066 590 63295351
Fungaemia 18.28 9.53 29 193052 2374 63293567
Central nervous system lupus 18.26 9.53 14 193067 500 63295441
Immune reconstitution inflammatory syndrome 18.21 9.53 50 193031 6034 63289907
Product label confusion 18.21 9.53 25 193056 1797 63294144
Chronic graft versus host disease oral 18.18 9.53 9 193072 143 63295798
Disseminated aspergillosis 18.16 9.53 8 193073 96 63295845
Hepatocellular injury 18.15 9.53 144 192937 27237 63268704
Osteonecrosis of jaw 18.12 9.53 51 193030 35072 63260869
Emphysematous pyelonephritis 18.11 9.53 11 193070 266 63295675
Disseminated varicella zoster virus infection 18.11 9.53 11 193070 266 63295675
Leukocytosis 18.08 9.53 138 192943 25797 63270144
Bone pain 18.07 9.53 95 192986 54546 63241395
Anal erythema 18.06 9.53 10 193071 202 63295739
Torsade de pointes 18.05 9.53 9 193072 13342 63282599
Enterococcus test positive 18.05 9.53 20 193061 1153 63294788
Ureteral disorder 17.98 9.53 12 193069 343 63295598
Glomerulonephritis chronic 17.96 9.53 9 193072 147 63295794
Transient ischaemic attack 17.91 9.53 57 193024 37696 63258245
Low birth weight baby 17.88 9.53 55 193026 7074 63288867
Haemodynamic instability 17.81 9.53 65 193016 9125 63286816
Hallucination 17.74 9.53 96 192985 54721 63241220
Atrial fibrillation 17.63 9.53 249 192832 116387 63179554
Parainfluenzae virus infection 17.59 9.53 28 193053 2299 63293642
Blood thyroid stimulating hormone increased 17.58 9.53 55 193026 7139 63288802
Shock 17.58 9.53 127 192954 23336 63272605
Germ cell cancer 17.57 9.53 7 193074 64 63295877
Eye infection toxoplasmal 17.47 9.53 11 193070 284 63295657
Asymptomatic bacteriuria 17.43 9.53 11 193070 285 63295656
Myelopathy 17.37 9.53 31 193050 2795 63293146
Injury 17.29 9.53 141 192940 73106 63222835
Bone erosion 17.27 9.53 17 193064 17700 63278241
Syncope 17.25 9.53 252 192829 117133 63178808
Hepatitis 17.20 9.53 191 192890 39597 63256344
Graft versus host disease in lung 17.18 9.53 12 193069 370 63295571
Visceral leishmaniasis 17.13 9.53 14 193067 549 63295392
Transaminases increased 17.13 9.53 158 192923 31209 63264732
Mycobacterial infection 17.12 9.53 24 193057 1759 63294182
Pain in jaw 17.11 9.53 71 193010 43425 63252516
Moyamoya disease 17.02 9.53 7 193074 70 63295871
Blood uric acid increased 16.96 9.53 45 193036 5322 63290619
Injection site mass 16.95 9.53 19 193062 18637 63277304
Nightmare 16.95 9.53 20 193061 19174 63276767
Pneumonia acinetobacter 16.95 9.53 6 193075 38 63295903
Eosinopenia 16.95 9.53 6 193075 38 63295903
Obliterative bronchiolitis 16.94 9.53 26 193055 2069 63293872
Cytopenia 16.85 9.53 75 193006 11526 63284415
Band neutrophil count increased 16.82 9.53 12 193069 383 63295558
Stress cardiomyopathy 16.79 9.53 65 193016 9385 63286556
Suicidal ideation 16.71 9.53 116 192965 62305 63233636
Hepatitis toxic 16.65 9.53 33 193048 3220 63292721
Blood gases abnormal 16.62 9.53 16 193065 781 63295160
Pneumonia cryptococcal 16.62 9.53 16 193065 781 63295160
Tendon rupture 16.59 9.53 59 193022 8180 63287761
Transient hypogammaglobulinaemia of infancy 16.57 9.53 6 193075 41 63295900
Orbital apex syndrome 16.57 9.53 6 193075 41 63295900
Passenger lymphocyte syndrome 16.51 9.53 7 193074 76 63295865
Plasma cell myeloma 16.48 9.53 55 193026 35850 63260091
Biliary anastomosis complication 16.44 9.53 6 193075 42 63295899
Hepatitis acute 16.43 9.53 63 193018 9057 63286884
Tardive dyskinesia 16.40 9.53 3 193078 8499 63287442
Oral pain 16.36 9.53 39 193042 28355 63267586
Thyroid stimulating immunoglobulin increased 16.35 9.53 7 193074 78 63295863
Diabetic macroangiopathy 16.28 9.53 8 193073 125 63295816
Tubulointerstitial nephritis 16.25 9.53 110 192971 19793 63276148
Aspergilloma 16.24 9.53 10 193071 248 63295693
Granuloma skin 16.22 9.53 3 193078 8434 63287507
Dyspnoea 16.14 9.53 1763 191318 659550 62636391
Medication error 16.14 9.53 93 192988 52191 63243750
Penicillium infection 16.11 9.53 8 193073 128 63295813
Renal graft infection 16.10 9.53 10 193071 252 63295689
Encephalitis Japanese B 16.09 9.53 6 193075 45 63295896
Premenstrual syndrome 16.07 9.53 15 193066 704 63295237
Wound infection bacterial 16.07 9.53 14 193067 600 63295341
Spinal cord infarction 16.03 9.53 10 193071 254 63295687
Epstein-Barr virus associated lymphoma 16.01 9.53 13 193068 505 63295436
Aortitis salmonella 16.01 9.53 5 193076 20 63295921
Delayed engraftment 16.00 9.53 8 193073 130 63295811
Injection site haemorrhage 16.00 9.53 31 193050 24283 63271658
Foetal growth restriction 16.00 9.53 55 193026 7498 63288443
Interleukin level increased 15.98 9.53 12 193069 415 63295526
Toxic neuropathy 15.96 9.53 12 193069 416 63295525
Allergy test positive 15.95 9.53 14 193067 606 63295335
Renal artery stenosis 15.87 9.53 24 193057 1885 63294056
Creatinine urine decreased 15.86 9.53 9 193072 191 63295750
Blood parathyroid hormone decreased 15.86 9.53 5 193076 9786 63286155
Globulins decreased 15.85 9.53 10 193071 259 63295682
Steroid dependence 15.85 9.53 23 193058 1741 63294200
Influenza 15.83 9.53 438 192643 108284 63187657
Pseudomonal bacteraemia 15.76 9.53 22 193059 1606 63294335
Coronavirus infection 15.74 9.53 38 193043 4240 63291701
Menstruation irregular 15.71 9.53 52 193029 6952 63288989
Breast cancer female 15.70 9.53 11 193070 13548 63282393
Serratia infection 15.68 9.53 17 193064 956 63294985
Pulmonary hypertension 15.62 9.53 59 193022 37064 63258877
Excessive skin 15.58 9.53 8 193073 138 63295803
Blood lactate dehydrogenase increased 15.56 9.53 122 192959 22994 63272947
Aplastic anaemia 15.54 9.53 64 193017 9505 63286436
Sinus polyp degeneration 15.54 9.53 6 193075 50 63295891
Amnesia 15.53 9.53 102 192979 55483 63240458
Mouth ulceration 15.50 9.53 161 192920 32823 63263118
Refractory anaemia with an excess of blasts 15.49 9.53 12 193069 435 63295506
Parathyroid hyperplasia 15.47 9.53 8 193073 140 63295801
Bacterial infection 15.46 9.53 107 192974 19392 63276549
Fusarium infection 15.46 9.53 14 193067 632 63295309
Allergy to plants 15.43 9.53 15 193066 741 63295200
Product dispensing error 15.42 9.53 6 193075 10299 63285642
Organic brain syndrome 15.41 9.53 9 193072 202 63295739
Prescribed underdose 15.40 9.53 43 193038 29646 63266295
Abscess 15.37 9.53 95 192986 16573 63279368
Erythrosis 15.34 9.53 6 193075 52 63295889
Normal newborn 15.34 9.53 58 193023 8283 63287658
Pyometra 15.33 9.53 7 193074 92 63295849
Dengue fever 15.29 9.53 14 193067 641 63295300
Seroconversion test positive 15.28 9.53 5 193076 24 63295917
Pharyngeal disorder 15.27 9.53 24 193057 1949 63293992
Vitamin B12 increased 15.27 9.53 18 193063 1110 63294831
Cestode infection 15.26 9.53 10 193071 277 63295664
Infective pulmonary exacerbation of cystic fibrosis 15.21 9.53 4 193077 8813 63287128
Hypokalaemia 15.20 9.53 223 192858 103581 63192360
Blood immunoglobulin G decreased 15.15 9.53 27 193054 2431 63293510
Ovarian fibroma 15.06 9.53 7 193074 96 63295845
Monocyte count decreased 15.04 9.53 25 193056 2128 63293813
Vascular rupture 15.03 9.53 22 193059 1678 63294263
Ulcer 15.02 9.53 133 192948 25974 63269967
Dystonia 14.99 9.53 12 193069 13807 63282134
Japanese spotted fever 14.95 9.53 5 193076 26 63295915
Infected varicose vein 14.95 9.53 5 193076 26 63295915
Polyglandular disorder 14.95 9.53 5 193076 26 63295915
Nasal septum disorder 14.93 9.53 8 193073 151 63295790
Chest pain 14.93 9.53 522 192559 215437 63080504
Vesicoureteric reflux 14.91 9.53 9 193072 215 63295726
Mucous stools 14.85 9.53 37 193044 4211 63291730
Escherichia bacteraemia 14.84 9.53 35 193046 3848 63292093
Blood beta-D-glucan increased 14.80 9.53 9 193072 218 63295723
Adenoviral haemorrhagic cystitis 14.75 9.53 8 193073 155 63295786
Mucocutaneous leishmaniasis 14.74 9.53 11 193070 377 63295564
Poikiloderma 14.73 9.53 9 193072 220 63295721
Meningitis chemical 14.70 9.53 8 193073 156 63295785
Respiratory distress 14.68 9.53 163 192918 33788 63262153
Inflammatory marker increased 14.66 9.53 50 193031 6789 63289152
Nail bed inflammation 14.64 9.53 11 193070 381 63295560
Intestinal infarction 14.62 9.53 17 193064 1033 63294908
Impaired work ability 14.61 9.53 19 193062 17456 63278485
Lung transplant rejection 14.60 9.53 16 193065 911 63295030
Hypoproteinaemia 14.60 9.53 24 193057 2025 63293916
Injection site reaction 14.59 9.53 111 192970 58413 63237528
Onychomycosis 14.46 9.53 55 193026 7877 63288064
Lymphocele 14.45 9.53 15 193066 802 63295139
Venous thrombosis 14.39 9.53 40 193041 4862 63291079
Paralysis 14.37 9.53 64 193017 9836 63286105
Spinal disorder 14.37 9.53 64 193017 9838 63286103
Neuralgia 14.36 9.53 131 192950 25795 63270146
Type IIb hyperlipidaemia 14.36 9.53 5 193076 30 63295911
Injection site warmth 14.34 9.53 15 193066 15180 63280761
Complications of transplanted liver 14.32 9.53 11 193070 394 63295547
Type 1 diabetes mellitus 14.31 9.53 34 193047 3756 63292185
Paraparesis 14.25 9.53 25 193056 2223 63293718
Autoimmune thyroiditis 14.24 9.53 35 193046 3951 63291990
Central nervous system vasculitis 14.22 9.53 16 193065 938 63295003
Hepatic artery aneurysm 14.21 9.53 4 193077 10 63295931
Nodular regenerative hyperplasia 14.19 9.53 12 193069 494 63295447
Hyperpyrexia 14.17 9.53 33 193048 3599 63292342
Dementia 14.16 9.53 22 193059 18772 63277169
Oropharyngeal pain 14.14 9.53 382 192699 94105 63201836
Spinal cord paralysis 14.08 9.53 5 193076 32 63295909
Hairy cell leukaemia 14.08 9.53 6 193075 66 63295875
Diffuse large B-cell lymphoma refractory 14.02 9.53 18 193063 1212 63294729
Immune effector cell-associated neurotoxicity syndrome 14.02 9.53 25 193056 2252 63293689
Haemostasis 14.00 9.53 9 193072 241 63295700
Human polyomavirus infection 13.99 9.53 10 193071 320 63295621
Blood urea increased 13.97 9.53 132 192949 26247 63269694
Enteritis 13.92 9.53 56 193025 8230 63287711
Blood loss anaemia 13.87 9.53 5 193076 8996 63286945
Cortisol decreased 13.86 9.53 18 193063 1226 63294715
Fungal skin infection 13.85 9.53 38 193043 4584 63291357
Cryptococcal cutaneous infection 13.85 9.53 6 193075 69 63295872
Propofol infusion syndrome 13.83 9.53 16 193065 967 63294974
Necrosis ischaemic 13.82 9.53 15 193066 845 63295096
Thrombosis 13.80 9.53 128 192953 64627 63231314
Angiocentric lymphoma 13.79 9.53 13 193068 618 63295323
Osteogenesis imperfecta 13.76 9.53 13 193068 620 63295321
Pyelonephritis acute 13.75 9.53 38 193043 4603 63291338
Therapy cessation 13.75 9.53 47 193034 30410 63265531
Heliotrope rash 13.72 9.53 8 193073 179 63295762
Laryngeal mass 13.70 9.53 5 193076 35 63295906
Mean cell haemoglobin concentration increased 13.68 9.53 12 193069 519 63295422
Chromoblastomycosis 13.58 9.53 5 193076 36 63295905
Mental status changes 13.57 9.53 68 193013 39531 63256410
Toxic epidermal necrolysis 13.53 9.53 127 192954 25207 63270734
Varicose ulceration 13.49 9.53 12 193069 529 63295412
Otitis media 13.47 9.53 39 193042 4852 63291089
Subcutaneous haematoma 13.44 9.53 21 193060 1697 63294244
Treatment noncompliance 13.43 9.53 63 193018 37262 63258679
Locked-in syndrome 13.42 9.53 11 193070 433 63295508
Nosocomial infection 13.41 9.53 21 193060 1700 63294241
Live birth 13.38 9.53 37 193044 25593 63270348
Dyskinesia 13.37 9.53 51 193030 31951 63263990
Moraxella infection 13.36 9.53 11 193070 436 63295505
Creatinine renal clearance decreased 13.36 9.53 18 193063 16290 63279651
Hepatic artery thrombosis 13.33 9.53 6 193075 76 63295865
Pneumonia pseudomonal 13.33 9.53 26 193055 2507 63293434
Therapeutic response decreased 13.33 9.53 262 192819 61263 63234678
Disability 13.33 9.53 22 193059 18325 63277616
Meningitis listeria 13.31 9.53 13 193068 646 63295295
Candida test positive 13.31 9.53 15 193066 881 63295060
Cutaneous lupus erythematosus 13.27 9.53 27 193054 2685 63293256
Muscle hypertrophy 13.26 9.53 6 193075 77 63295864
Jaundice cholestatic 13.26 9.53 3 193078 7321 63288620
Herpes simplex encephalitis 13.24 9.53 10 193071 349 63295592
Occult blood 13.23 9.53 18 193063 1283 63294658
Body temperature increased 13.21 9.53 172 192909 37020 63258921
Hypomagnesaemia 13.21 9.53 44 193037 28693 63267248
Oropharyngeal plaque 13.19 9.53 9 193072 267 63295674
Leukocyturia 13.17 9.53 19 193062 1430 63294511
Vasculitis necrotising 13.17 9.53 12 193069 546 63295395
Inflammatory pain 13.09 9.53 15 193066 897 63295044
Pseudomonal sepsis 13.07 9.53 25 193056 2376 63293565
Right ventricular failure 13.06 9.53 20 193061 17168 63278773
Encephalopathy 13.05 9.53 177 192904 38443 63257498
Encephalitis brain stem 13.02 9.53 7 193074 133 63295808
Capillaritis 13.02 9.53 7 193074 133 63295808
Bone loss 13.02 9.53 29 193052 3070 63292871
Varicella 13.01 9.53 22 193059 1899 63294042
Extremity necrosis 13.01 9.53 20 193061 1593 63294348
Pain in extremity 13.00 9.53 851 192230 330635 62965306
Thrombotic thrombocytopenic purpura 12.98 9.53 33 193048 3803 63292138
Myelocyte count increased 12.97 9.53 10 193071 360 63295581
Neurosarcoidosis 12.97 9.53 8 193073 199 63295742
Reticulocytopenia 12.93 9.53 6 193075 82 63295859
Urinoma 12.92 9.53 5 193076 42 63295899
Musculoskeletal pain 12.90 9.53 200 192881 92077 63203864
Labelled drug-drug interaction medication error 12.90 9.53 13 193068 13386 63282555
Asthenia 12.89 9.53 998 192083 382606 62913335
Product complaint 12.83 9.53 12 193069 12797 63283144
Flatulence 12.82 9.53 58 193023 34644 63261297
Injection site induration 12.80 9.53 6 193075 9220 63286721
Evans syndrome 12.79 9.53 8 193073 204 63295737
Myelocyte percentage increased 12.72 9.53 8 193073 206 63295735
Blindness 12.72 9.53 111 192970 21588 63274353
Retinal depigmentation 12.70 9.53 9 193072 284 63295657
Body temperature fluctuation 12.70 9.53 24 193057 2261 63293680
Device leakage 12.66 9.53 3 193078 7093 63288848
Lip swelling 12.66 9.53 50 193031 31013 63264928
Cells in urine 12.65 9.53 8 193073 208 63295733
Wrist deformity 12.62 9.53 23 193058 2107 63293834
Bacillus bacteraemia 12.61 9.53 6 193075 87 63295854
Influenza like illness 12.61 9.53 136 192945 66688 63229253
Microsporidia infection 12.59 9.53 9 193072 288 63295653
Joint effusion 12.59 9.53 92 192989 16968 63278973
Acarodermatitis 12.58 9.53 16 193065 1067 63294874
Ecthyma 12.57 9.53 9 193072 289 63295652
Therapeutic product effect incomplete 12.54 9.53 287 192794 124769 63171172
Brain oedema 12.52 9.53 80 193001 14115 63281826
Cancer in remission 12.52 9.53 5 193076 46 63295895
Specific gravity urine increased 12.52 9.53 8 193073 212 63295729
Beta 2 microglobulin increased 12.49 9.53 7 193074 145 63295796
Intestine transplant rejection 12.43 9.53 5 193076 47 63295894
Diffuse large B-cell lymphoma stage III 12.43 9.53 5 193076 47 63295894
Adult T-cell lymphoma/leukaemia 12.36 9.53 8 193073 217 63295724
Breast cancer metastatic 12.34 9.53 11 193070 12007 63283934
Cryptococcal fungaemia 12.34 9.53 5 193076 48 63295893
Tri-iodothyronine free increased 12.32 9.53 8 193073 218 63295723
Coloboma 12.25 9.53 6 193075 93 63295848
Mean cell volume decreased 12.21 9.53 33 193048 3945 63291996
Nodal osteoarthritis 12.16 9.53 14 193067 842 63295099
Mean cell haemoglobin concentration decreased 12.15 9.53 31 193050 3581 63292360
Procedural pain 12.13 9.53 30 193051 21539 63274402
Neonatal pneumonia 12.09 9.53 4 193077 20 63295921
Microangiopathic haemolytic anaemia 12.05 9.53 12 193069 611 63295330
Kidney fibrosis 12.03 9.53 21 193060 1860 63294081
Complication of device insertion 12.01 9.53 4 193077 7560 63288381
Lymphocyte count increased 11.97 9.53 30 193051 3428 63292513
Encephalitis viral 11.95 9.53 20 193061 1712 63294229
Skin haemorrhage 11.94 9.53 8 193073 10086 63285855
Haemoperitoneum 11.91 9.53 26 193055 2715 63293226
Fracture pain 11.85 9.53 13 193068 741 63295200
Low cardiac output syndrome 11.84 9.53 10 193071 411 63295530
Urinary casts 11.84 9.53 13 193068 742 63295199
Ureteral necrosis 11.82 9.53 5 193076 54 63295887
Hypertensive encephalopathy 11.81 9.53 12 193069 626 63295315
Hypertrichosis 11.78 9.53 16 193065 1138 63294803
Genital herpes 11.78 9.53 20 193061 1732 63294209
Anti-cyclic citrullinated peptide antibody 11.78 9.53 3 193078 6755 63289186
Coagulation factor VIII level increased 11.77 9.53 4 193077 22 63295919
Peripheral venous disease 11.77 9.53 18 193063 15459 63280482
Pyuria 11.77 9.53 21 193060 1893 63294048
Product contamination 11.76 9.53 13 193068 747 63295194
Rectal haemorrhage 11.75 9.53 94 192987 48936 63247005
Throat clearing 11.74 9.53 24 193057 2395 63293546
Hallucination, auditory 11.72 9.53 13 193068 12811 63283130
Nose deformity 11.72 9.53 7 193074 164 63295777
Haematuria 11.72 9.53 138 192943 29019 63266922
Escherichia pyelonephritis 11.71 9.53 10 193071 417 63295524
Eosinophil percentage increased 11.64 9.53 15 193066 1014 63294927
Schizophrenia 11.62 9.53 8 193073 9944 63285997
Monocyte percentage decreased 11.62 9.53 8 193073 241 63295700
Aplasia pure red cell 11.61 9.53 35 193046 4452 63291489
Respiratory tract infection 11.61 9.53 184 192897 41299 63254642
Dry throat 11.59 9.53 46 193035 6719 63289222
Hepatic haemorrhage 11.58 9.53 11 193070 528 63295413
Abnormal dreams 11.57 9.53 9 193072 10507 63285434
Paraesthesia ear 11.50 9.53 8 193073 245 63295696
Tuberculosis of genitourinary system 11.48 9.53 4 193077 24 63295917
Hepatic failure 11.48 9.53 162 192919 35494 63260447
Nasal herpes 11.43 9.53 10 193071 431 63295510
Alopecia scarring 11.40 9.53 6 193075 109 63295832
Dislocation of vertebra 11.40 9.53 6 193075 8629 63287312
Angiosarcoma 11.39 9.53 8 193073 249 63295692
Pneumocephalus 11.39 9.53 7 193074 173 63295768
Noninfective encephalitis 11.37 9.53 10 193071 434 63295507
Coma 11.36 9.53 133 192948 64231 63231710
Mycoplasma test positive 11.35 9.53 5 193076 60 63295881
Cerebral venous sinus thrombosis 11.32 9.53 21 193060 1951 63293990
Morganella infection 11.30 9.53 12 193069 659 63295282
Hypercalcaemia 11.28 9.53 46 193035 28276 63267665
Needle issue 11.27 9.53 9 193072 10367 63285574
Complications of transplant surgery 11.25 9.53 7 193074 177 63295764
Peripheral sensorimotor neuropathy 11.24 9.53 18 193063 1485 63294456
Aspergillus test positive 11.23 9.53 9 193072 343 63295598
Gastrointestinal pain 11.23 9.53 8 193073 9768 63286173
Cerebral vasoconstriction 11.22 9.53 16 193065 1192 63294749
Pneumonia legionella 11.21 9.53 19 193062 1643 63294298
Acute motor axonal neuropathy 11.21 9.53 4 193077 26 63295915
Intestinal obstruction 11.20 9.53 52 193029 30847 63265094
Akathisia 11.16 9.53 7 193074 9139 63286802
Haematemesis 11.14 9.53 51 193030 30361 63265580
Pneumonia necrotising 11.12 9.53 10 193071 447 63295494
Hypoxia 11.12 9.53 249 192832 59543 63236398
Osseous cryptococcosis 11.12 9.53 3 193078 6 63295935
Haemangioma-thrombocytopenia syndrome 11.12 9.53 3 193078 6 63295935
Erectile dysfunction 11.12 9.53 3 193078 6 63295935
Osteoarthropathy 11.12 9.53 3 193078 6 63295935
B-lymphocyte count increased 11.07 9.53 6 193075 116 63295825
Thyroid stimulating immunoglobulin 11.06 9.53 5 193076 64 63295877
Acid base balance abnormal 11.06 9.53 8 193073 261 63295680
Enterocolitis viral 11.06 9.53 8 193073 261 63295680
Injection site urticaria 11.06 9.53 16 193065 14057 63281884
Focal nodular hyperplasia 11.04 9.53 11 193070 560 63295381
Adjusted calcium decreased 11.04 9.53 7 193074 183 63295758
Lower respiratory tract congestion 11.01 9.53 26 193055 2860 63293081
Fear of injection 11.01 9.53 4 193077 7160 63288781
Lupus endocarditis 11.01 9.53 8 193073 263 63295678
Microscopic polyangiitis 11.01 9.53 7 193074 184 63295757
Metastases to liver 11.00 9.53 36 193045 23603 63272338
Zinc deficiency 11.00 9.53 5 193076 65 63295876
Oesophageal candidiasis 10.93 9.53 40 193041 5623 63290318
Pneumonia fungal 10.93 9.53 39 193042 5416 63290525
Arteriovenous fistula 10.93 9.53 8 193073 266 63295675
Magnetic resonance imaging abnormal 10.92 9.53 27 193054 3058 63292883
Fungal infection 10.87 9.53 165 192916 36709 63259232
Enterobacter pneumonia 10.84 9.53 4 193077 29 63295912
Hepatitis C 10.82 9.53 38 193043 5236 63290705
Histiocytic sarcoma 10.80 9.53 5 193076 68 63295873
Polychondritis 10.79 9.53 10 193071 465 63295476
Skin striae 10.79 9.53 17 193064 1384 63294557
Gastroenteritis salmonella 10.78 9.53 12 193069 695 63295246
Transplant dysfunction 10.78 9.53 36 193045 4836 63291105
Lower respiratory tract infection bacterial 10.78 9.53 10 193071 466 63295475
Eosinophil count abnormal 10.77 9.53 11 193070 577 63295364
Carcinoma in situ 10.76 9.53 6 193075 123 63295818
Hemivertebra 10.76 9.53 6 193075 123 63295818
Bile duct stenosis 10.74 9.53 16 193065 1240 63294701
Fluorosis 10.73 9.53 5 193076 69 63295872
Vaginal haemorrhage 10.73 9.53 45 193036 27442 63268499
Glomerular filtration rate abnormal 10.72 9.53 13 193068 826 63295115
Magnesium deficiency 10.71 9.53 11 193070 581 63295360
Pterygium 10.68 9.53 7 193074 194 63295747
Joint stiffness 10.63 9.53 79 193002 41790 63254151
Hydronephrosis 10.62 9.53 62 193019 10600 63285341
Hepatic artery stenosis 10.61 9.53 4 193077 31 63295910
Head injury 10.60 9.53 45 193036 27351 63268590
Mycobacterium kansasii infection 10.59 9.53 6 193075 127 63295814
Ingrown hair 10.57 9.53 11 193070 590 63295351
CD4 lymphocytes decreased 10.55 9.53 17 193064 1410 63294531
Secondary adrenocortical insufficiency 10.54 9.53 17 193064 1411 63294530
Severe myoclonic epilepsy of infancy 10.54 9.53 5 193076 72 63295869
Lung neoplasm malignant 10.51 9.53 28 193053 19605 63276336
Dysphagia 10.51 9.53 348 192733 88237 63207704
Paralogism 10.50 9.53 4 193077 32 63295909
Salmonella test positive 10.50 9.53 4 193077 32 63295909
Haematoma muscle 10.47 9.53 15 193066 1122 63294819
Hyperferritinaemia 10.46 9.53 7 193074 201 63295740
Glomerulonephritis membranous 10.44 9.53 11 193070 599 63295342
Fracture 10.43 9.53 28 193053 19556 63276385
Therapy interrupted 10.41 9.53 57 193024 32398 63263543
Nitrite urine 10.40 9.53 4 193077 33 63295908
Epilepsy 10.40 9.53 127 192954 26938 63269003
Ocular procedural complication 10.37 9.53 9 193072 384 63295557
Endometrial disorder 10.35 9.53 12 193069 727 63295214
Acute disseminated encephalomyelitis 10.34 9.53 7 193074 205 63295736
Normochromic anaemia 10.33 9.53 8 193073 290 63295651
Complement factor C3 decreased 10.33 9.53 8 193073 290 63295651
Thrombocytosis 10.32 9.53 40 193041 5778 63290163
Histoplasmosis disseminated 10.30 9.53 17 193064 1439 63294502
Eosinophilic myocarditis 10.29 9.53 11 193070 609 63295332
Jaundice 10.27 9.53 135 192946 29116 63266825
Enterovirus infection 10.27 9.53 14 193067 1000 63294941
Visual tracking test abnormal 10.26 9.53 3 193078 9 63295932
Myocardiac abscess 10.26 9.53 3 193078 9 63295932
Bilirubin conjugated increased 10.24 9.53 25 193056 2809 63293132
Cholecystitis acute 10.24 9.53 51 193030 8209 63287732
Liver disorder 10.24 9.53 109 192972 53578 63242363
Urobilinogen urine increased 10.24 9.53 8 193073 294 63295647
Ophthalmoplegia 10.23 9.53 17 193064 1447 63294494
Waxy flexibility 10.22 9.53 6 193075 136 63295805
Spinal stroke 10.19 9.53 4 193077 35 63295906
Factor XIII Inhibition 10.19 9.53 4 193077 35 63295906
Acid fast bacilli infection 10.18 9.53 5 193076 78 63295863
Disseminated cytomegaloviral infection 10.16 9.53 7 193074 211 63295730
Reticulocytosis 10.14 9.53 6 193075 138 63295803
Sopor 10.14 9.53 34 193047 22130 63273811
Premature baby 10.12 9.53 102 192979 20633 63275308
Hepatic function abnormal 10.11 9.53 164 192917 36978 63258963
Cystitis klebsiella 10.10 9.53 7 193074 213 63295728
Oesophageal adenocarcinoma recurrent 10.09 9.53 4 193077 36 63295905
Bone marrow reticulin fibrosis 10.08 9.53 7 193074 214 63295727
Euthyroid sick syndrome 10.07 9.53 5 193076 80 63295861
Diverticulum 10.06 9.53 13 193068 11978 63283963
Central nervous system lesion 10.05 9.53 61 193020 10574 63285367
Leishmaniasis 10.02 9.53 5 193076 81 63295860
Joint injury 10.01 9.53 51 193030 29521 63266420
Skin infection 10.00 9.53 79 193002 14923 63281018
Erythema migrans 10.00 9.53 4 193077 37 63295904
Surgery 9.98 9.53 66 193015 35846 63260095
Impaired gastric emptying 9.97 9.53 10 193071 10322 63285619
Multiple fractures 9.97 9.53 7 193074 8611 63287330
T-lymphocyte count decreased 9.92 9.53 8 193073 308 63295633
Plasma cells decreased 9.90 9.53 4 193077 38 63295903
Immature granulocyte count increased 9.89 9.53 9 193072 409 63295532
Herpes simplex hepatitis 9.89 9.53 9 193072 409 63295532
Post procedural bile leak 9.88 9.53 6 193075 145 63295796
Respiratory tract congestion 9.87 9.53 25 193056 17807 63278134
Road traffic accident 9.84 9.53 68 193013 36564 63259377
Neoplasm malignant 9.82 9.53 52 193029 29809 63266132
Gait disturbance 9.81 9.53 456 192625 182722 63113219
Pancreas transplant rejection 9.81 9.53 6 193075 147 63295794
Crystalluria 9.80 9.53 9 193072 414 63295527
Blastomycosis 9.76 9.53 8 193073 315 63295626
Tuberous sclerosis complex 9.75 9.53 5 193076 86 63295855
Haemophilia 9.75 9.53 5 193076 86 63295855
Benign mediastinal neoplasm 9.72 9.53 4 193077 40 63295901
Drug withdrawal syndrome 9.72 9.53 46 193035 27148 63268793
CSF test abnormal 9.70 9.53 8 193073 318 63295623
Organising pneumonia 9.67 9.53 39 193042 5737 63290204
Epiglottic erythema 9.64 9.53 4 193077 41 63295900
Meningitis cryptococcal 9.64 9.53 16 193065 1361 63294580
Respiratory tract oedema 9.63 9.53 10 193071 535 63295406
Multiple allergies 9.61 9.53 17 193064 13785 63282156
Cytomegalovirus duodenitis 9.60 9.53 3 193078 12 63295929
Limbic encephalitis 9.59 9.53 8 193073 323 63295618
Injection site discolouration 9.58 9.53 6 193075 7842 63288099
Mediastinal cyst 9.55 9.53 4 193077 42 63295899

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 1078.85 10.36 3583 119988 415941 34417419
Cytomegalovirus infection 885.45 10.36 736 122835 25399 34807961
Product use in unapproved indication 523.39 10.36 1230 122341 116269 34717091
Drug ineffective for unapproved indication 517.28 10.36 522 123049 23193 34810167
Drug ineffective 443.84 10.36 2940 120631 453811 34379549
Aspergillus infection 351.60 10.36 314 123257 11940 34821420
Pneumocystis jirovecii pneumonia 348.35 10.36 388 123183 19322 34814038
Death 335.92 10.36 558 123013 397491 34435869
Bronchopulmonary aspergillosis 329.37 10.36 328 123243 14331 34819029
Post transplant lymphoproliferative disorder 324.39 10.36 231 123340 6297 34827063
Transplant rejection 323.50 10.36 278 123293 10033 34823327
Mucormycosis 322.63 10.36 222 123349 5720 34827640
Kidney transplant rejection 302.36 10.36 234 123337 7263 34826097
Multiple organ dysfunction syndrome 294.23 10.36 758 122813 75808 34757552
Strongyloidiasis 283.32 10.36 154 123417 2557 34830803
Graft versus host disease 268.48 10.36 253 123318 10316 34823044
Completed suicide 262.03 10.36 23 123548 98145 34735215
Drug abuse 257.11 10.36 26 123545 99070 34734290
Posterior reversible encephalopathy syndrome 248.50 10.36 236 123335 9718 34823642
Respiratory failure 245.97 10.36 893 122678 107679 34725681
Epstein-Barr virus infection 237.93 10.36 205 123366 7423 34825937
Fatigue 225.27 10.36 624 122947 370029 34463331
Septic shock 211.75 10.36 646 122925 71188 34762172
Cytomegalovirus viraemia 208.40 10.36 188 123383 7242 34826118
Cytomegalovirus infection reactivation 202.58 10.36 158 123413 4960 34828400
Fall 194.23 10.36 260 123311 202625 34630735
Graft versus host disease in gastrointestinal tract 189.16 10.36 133 123438 3550 34829810
Dizziness 186.80 10.36 303 123268 218218 34615142
Thrombotic microangiopathy 185.62 10.36 208 123363 10422 34822938
Pneumatosis intestinalis 183.88 10.36 134 123437 3789 34829571
Adenovirus infection 179.82 10.36 149 123422 5108 34828252
Nocardiosis 178.51 10.36 132 123439 3819 34829541
Polyomavirus-associated nephropathy 174.97 10.36 129 123442 3715 34829645
Acute graft versus host disease in skin 160.63 10.36 139 123432 5062 34828298
Product dose omission issue 160.04 10.36 114 123457 119597 34713763
Nausea 155.93 10.36 646 122925 339262 34494098
Candida infection 150.61 10.36 244 123327 17471 34815889
Complications of transplanted kidney 150.13 10.36 127 123444 4482 34828878
Infusion related reaction 149.65 10.36 470 123101 52587 34780773
BK virus infection 141.23 10.36 135 123436 5603 34827757
Haemophagocytic lymphohistiocytosis 137.57 10.36 198 123373 12775 34820585
Pneumonia cytomegaloviral 135.66 10.36 101 123470 2953 34830407
Enterococcal infection 134.04 10.36 165 123406 9141 34824219
Cystitis haemorrhagic 132.97 10.36 130 123441 5549 34827811
Cardiac failure congestive 132.91 10.36 64 123507 83206 34750154
Toxicity to various agents 131.48 10.36 324 123247 200038 34633322
Pseudomonas infection 126.96 10.36 186 123385 12196 34821164
Pneumomediastinum 122.77 10.36 86 123485 2281 34831079
Klebsiella infection 122.46 10.36 151 123420 8380 34824980
Graft versus host disease in skin 121.42 10.36 105 123466 3820 34829540
Acute graft versus host disease in liver 120.84 10.36 73 123498 1493 34831867
Parvovirus B19 infection 116.39 10.36 58 123513 797 34832563
Human herpesvirus 6 infection 115.92 10.36 79 123492 2002 34831358
Disseminated mucormycosis 115.19 10.36 50 123521 490 34832870
Myocardial infarction 112.86 10.36 158 123413 120927 34712433
Acute graft versus host disease 111.40 10.36 126 123445 6377 34826983
Syncope 110.93 10.36 96 123475 91355 34742005
Rebound effect 110.32 10.36 92 123479 3182 34830178
Steroid diabetes 109.79 10.36 78 123493 2117 34831243
Asthenia 108.61 10.36 472 123099 244779 34588581
Blood pressure fluctuation 108.44 10.36 261 123310 24988 34808372
Acute graft versus host disease in intestine 105.87 10.36 83 123488 2625 34830735
Constipation 101.62 10.36 207 123364 136775 34696585
Dehydration 100.20 10.36 192 123379 129777 34703583
Vomiting 97.04 10.36 498 123073 247123 34586237
Cerebrovascular accident 96.95 10.36 94 123477 84717 34748643
Cytomegalovirus test positive 96.72 10.36 92 123479 3794 34829566
Immunosuppressant drug level increased 91.50 10.36 110 123461 5945 34827415
Drug resistance 89.63 10.36 247 123324 25680 34807680
Infection reactivation 88.54 10.36 59 123512 1439 34831921
Hospitalisation 87.38 10.36 46 123525 56856 34776504
Cytomegalovirus colitis 87.18 10.36 75 123496 2709 34830651
Overdose 86.65 10.36 117 123454 90942 34742418
Intentional overdose 82.14 10.36 26 123545 43648 34789712
Progressive multifocal leukoencephalopathy 80.97 10.36 133 123438 9631 34823729
Chronic graft versus host disease 80.53 10.36 88 123483 4285 34829075
Cushingoid 78.73 10.36 70 123501 2644 34830716
Blood pressure diastolic abnormal 78.55 10.36 91 123480 4727 34828633
Delayed graft function 78.15 10.36 64 123507 2157 34831203
Nephropathy toxic 78.04 10.36 151 123420 12437 34820923
Acute respiratory distress syndrome 77.78 10.36 235 123336 25734 34807626
Therapy non-responder 76.93 10.36 308 123263 38838 34794522
Focal segmental glomerulosclerosis 76.87 10.36 61 123510 1964 34831396
Disseminated intravascular coagulation 76.56 10.36 209 123362 21607 34811753
Renal tubular atrophy 73.74 10.36 48 123523 1124 34832236
Chronic allograft nephropathy 73.07 10.36 49 123522 1208 34832152
Pulmonary nocardiosis 71.80 10.36 43 123528 865 34832495
Herpes simplex 71.24 10.36 93 123478 5466 34827894
Lymphopenia 70.28 10.36 169 123402 16166 34817194
Depression 70.05 10.36 149 123422 96949 34736411
Hypoglycaemia 67.89 10.36 56 123515 54584 34778776
Confusional state 67.69 10.36 271 123300 143889 34689471
Pulmonary mucormycosis 66.95 10.36 39 123532 744 34832616
COVID-19 66.60 10.36 486 123085 77064 34756296
Pneumocystis jirovecii infection 66.51 10.36 53 123518 1717 34831643
Coronary artery disease 64.49 10.36 46 123525 48259 34785101
Rhinocerebral mucormycosis 64.21 10.36 34 123537 534 34832826
Liver transplant rejection 64.16 10.36 56 123515 2063 34831297
Decreased appetite 63.75 10.36 337 123234 166055 34667305
Oxygen saturation decreased 63.20 10.36 365 123206 53453 34779907
Bacterial sepsis 62.92 10.36 85 123486 5165 34828195
Cytomegalovirus oesophagitis 62.09 10.36 32 123539 474 34832886
Cryptococcosis 61.60 10.36 58 123513 2361 34830999
Fungal infection 61.33 10.36 158 123413 15777 34817583
Dyspnoea 60.81 10.36 952 122619 375830 34457530
Blood pressure systolic abnormal 60.10 10.36 72 123499 3876 34829484
Enterobacter infection 59.47 10.36 57 123514 2373 34830987
Transplant failure 59.43 10.36 68 123503 3485 34829875
Myopathy 59.09 10.36 128 123443 11426 34821934
COVID-19 pneumonia 58.00 10.36 161 123410 16806 34816554
Escherichia infection 57.47 10.36 104 123467 8141 34825219
Lymphocyte count decreased 57.07 10.36 193 123378 22429 34810931
Disseminated strongyloidiasis 56.93 10.36 23 123548 185 34833175
Injection site pain 56.32 10.36 34 123537 38971 34794389
Malaise 55.79 10.36 406 123165 185419 34647941
Leukopenia 55.73 10.36 397 123174 62459 34770901
Feeling abnormal 55.46 10.36 86 123485 63149 34770211
Wrong technique in product usage process 55.37 10.36 29 123542 35957 34797403
Hyperglycaemia 55.30 10.36 281 123290 39199 34794161
Mycobacterium chelonae infection 55.29 10.36 35 123536 780 34832580
Kidney fibrosis 54.03 10.36 52 123519 2176 34831184
Cardiac disorder 53.82 10.36 44 123527 43082 34790278
Cytomegalovirus enteritis 53.53 10.36 29 123542 478 34832882
Phaeohyphomycosis 53.42 10.36 35 123536 829 34832531
Rhabdomyolysis 53.09 10.36 100 123471 68063 34765297
Large intestine perforation 52.71 10.36 102 123469 8401 34824959
Anxiety 52.49 10.36 178 123393 99250 34734110
Pneumonia pseudomonal 52.43 10.36 67 123504 3855 34829505
Cytomegalovirus chorioretinitis 52.27 10.36 64 123507 3525 34829835
Stress 52.06 10.36 21 123550 30326 34803034
Blood pressure systolic increased 52.01 10.36 189 123382 22763 34810597
Pain 51.90 10.36 468 123103 204207 34629153
Muscle spasms 51.69 10.36 118 123453 74883 34758477
Mycobacterium abscessus infection 51.62 10.36 29 123542 515 34832845
Acinetobacter infection 51.57 10.36 39 123532 1168 34832192
Somnolence 50.81 10.36 211 123360 110905 34722455
Skin striae 50.38 10.36 30 123541 597 34832763
Renal transplant failure 50.07 10.36 37 123534 1069 34832291
Prostate cancer 50.04 10.36 40 123531 39609 34793751
Transplant dysfunction 49.99 10.36 54 123517 2595 34830765
Suicide attempt 49.95 10.36 39 123532 39077 34794283
Disease recurrence 49.58 10.36 178 123393 21312 34812048
Oliguria 48.89 10.36 98 123473 8282 34825078
Epstein-Barr viraemia 48.69 10.36 39 123532 1273 34832087
Aplasia 48.60 10.36 70 123501 4518 34828842
Amoebic colitis 48.55 10.36 17 123554 87 34833273
Central nervous system fungal infection 48.40 10.36 24 123547 326 34833034
Insomnia 47.69 10.36 197 123374 103710 34729650
Symptom masked 47.37 10.36 29 123542 608 34832752
Pneumonia cryptococcal 47.25 10.36 33 123538 871 34832489
JC virus infection 47 10.36 48 123523 2160 34831200
Necrotising retinitis 46.98 10.36 32 123539 810 34832550
Systemic mycosis 46.48 10.36 41 123530 1532 34831828
Pneumoretroperitoneum 46.33 10.36 18 123553 129 34833231
Diffuse large B-cell lymphoma 45.18 10.36 88 123483 7282 34826078
Disseminated cryptococcosis 44.75 10.36 38 123533 1348 34832012
Sepsis 44.71 10.36 832 122739 165729 34667631
Penicillium infection 44.59 10.36 17 123554 115 34833245
Fungaemia 44.39 10.36 50 123521 2518 34830842
Osmotic demyelination syndrome 44.19 10.36 31 123540 824 34832536
Dry skin 44.16 10.36 28 123543 31259 34802101
Diarrhoea 43.63 10.36 1048 122523 388864 34444496
Diffuse alveolar damage 43.36 10.36 47 123524 2267 34831093
Graft versus host disease in liver 43.09 10.36 36 123535 1248 34832112
Serotonin syndrome 42.96 10.36 9 123562 19924 34813436
Osteonecrosis 42.95 10.36 133 123438 14757 34818603
Corynebacterium infection 42.80 10.36 27 123544 598 34832762
Product prescribing error 42.48 10.36 14 123557 22913 34810447
Pneumonia acinetobacter 42.38 10.36 16 123555 105 34833255
Epstein-Barr virus associated lymphoproliferative disorder 42.36 10.36 43 123528 1921 34831439
Fusarium infection 42.02 10.36 34 123537 1126 34832234
Varicella zoster virus infection 41.64 10.36 41 123530 1765 34831595
Gastroenteritis norovirus 41.58 10.36 38 123533 1488 34831872
Atrial fibrillation 41.40 10.36 258 123313 122135 34711225
Loss of personal independence in daily activities 41.21 10.36 34 123537 33145 34800215
Subcutaneous emphysema 41.16 10.36 34 123537 1160 34832200
Systemic candida 41.16 10.36 58 123513 3668 34829692
Human herpesvirus 8 infection 40.54 10.36 31 123540 944 34832416
Condition aggravated 40.40 10.36 926 122645 191270 34642090
Staphylococcal sepsis 40.38 10.36 100 123471 9744 34823616
Glomerulonephritis 40.30 10.36 42 123529 1936 34831424
Glomerulosclerosis 40.28 10.36 29 123542 804 34832556
Pneumonia fungal 40.19 10.36 82 123489 7018 34826342
Proteinuria 40.13 10.36 151 123420 18491 34814869
Viraemia 40.09 10.36 34 123537 1204 34832156
Blood pressure increased 40.07 10.36 482 123089 87620 34745740
Back pain 40.02 10.36 259 123312 121530 34711830
Balance disorder 39.91 10.36 51 123520 40603 34792757
Cytomegalovirus hepatitis 39.42 10.36 23 123548 440 34832920
Lung abscess 39.30 10.36 48 123523 2637 34830723
Apoptosis 39.24 10.36 22 123549 389 34832971
Incision site pain 39.20 10.36 40 123531 1798 34831562
Full blood count abnormal 39.07 10.36 9 123562 18659 34814701
Intentional product misuse 39.07 10.36 63 123508 45548 34787812
Staphylococcal infection 38.98 10.36 223 123348 32537 34800823
Plasma cell myeloma 38.97 10.36 55 123516 41982 34791378
Pyrexia 38.94 10.36 1491 122080 331522 34501838
Drug effective for unapproved indication 38.87 10.36 47 123524 2555 34830805
Dural arteriovenous fistula 38.56 10.36 12 123559 39 34833321
Chorioretinopathy 38.40 10.36 36 123535 1457 34831903
Pneumoperitoneum 38.26 10.36 39 123532 1751 34831609
Product quality issue 38.17 10.36 7 123564 17028 34816332
Cutaneous mucormycosis 38.10 10.36 17 123554 179 34833181
Aplastic anaemia 38.07 10.36 97 123474 9619 34823741
Renal tubular necrosis 37.99 10.36 132 123439 15548 34817812
Tremor 37.63 10.36 157 123414 82430 34750930
Pathogen resistance 37.50 10.36 95 123476 9387 34823973
Pneumothorax 37.32 10.36 150 123421 18942 34814418
Hypoalbuminaemia 37.23 10.36 111 123460 12063 34821297
Cytokine release syndrome 37.21 10.36 170 123401 22707 34810653
Polychondritis 37.14 10.36 18 123553 232 34833128
Headache 37.13 10.36 493 123078 200142 34633218
Granulomatosis with polyangiitis 36.79 10.36 32 123539 1173 34832187
International normalised ratio increased 36.35 10.36 70 123501 47257 34786103
Suicidal ideation 36.30 10.36 54 123517 40334 34793026
Inappropriate schedule of product administration 36.04 10.36 107 123464 62189 34771171
Central nervous system infection 35.95 10.36 25 123546 655 34832705
Transient ischaemic attack 35.93 10.36 27 123544 27586 34805774
Oedema peripheral 35.32 10.36 263 123308 119549 34713811
Aggression 35.11 10.36 52 123519 38912 34794448
Intensive care unit acquired weakness 34.89 10.36 29 123542 998 34832362
Skin necrosis 34.81 10.36 69 123502 5784 34827576
Pulmonary alveolar haemorrhage 34.79 10.36 80 123491 7432 34825928
Myalgia 34.64 10.36 166 123405 83944 34749416
Osteomyelitis fungal 33.96 10.36 17 123554 236 34833124
Cytomegalovirus enterocolitis 33.63 10.36 28 123543 966 34832394
Opportunistic infection 33.41 10.36 35 123536 1623 34831737
Hallucination 33.11 10.36 84 123487 51414 34781946
Human ehrlichiosis 33.06 10.36 19 123552 353 34833007
Antineutrophil cytoplasmic antibody positive 32.76 10.36 25 123546 759 34832601
Red blood cells urine positive 32.61 10.36 36 123535 1773 34831587
Bradycardia 32.15 10.36 147 123424 75271 34758089
Arrhythmia 32.06 10.36 48 123523 35760 34797600
Heart rate decreased 32.00 10.36 207 123364 31538 34801822
Unevaluable event 31.87 10.36 41 123530 32549 34800811
Rheumatoid arthritis 31.86 10.36 238 123333 38000 34795360
Extrapyramidal disorder 31.81 10.36 4 123567 12876 34820484
Restlessness 31.79 10.36 26 123545 25456 34807904
Pseudomonal bacteraemia 31.75 10.36 32 123539 1417 34831943
Human polyomavirus infection 31.70 10.36 24 123547 720 34832640
Cerebral fungal infection 31.66 10.36 17 123554 275 34833085
Chest pain 31.58 10.36 291 123280 126471 34706889
Lethargy 31.42 10.36 61 123510 41061 34792299
Gait disturbance 31.14 10.36 175 123396 84965 34748395
Haemolytic uraemic syndrome 30.47 10.36 39 123532 2247 34831113
Disseminated varicella zoster virus infection 30.15 10.36 17 123554 304 34833056
Dysphagia 30.04 10.36 116 123455 62265 34771095
Perinephric abscess 29.96 10.36 10 123561 43 34833317
Immunosuppressant drug level decreased 29.91 10.36 29 123542 1225 34832135
Erectile dysfunction 29.77 10.36 18 123553 20619 34812741
Hyperhidrosis 29.67 10.36 152 123419 75540 34757820
Parvovirus infection 29.60 10.36 19 123552 434 34832926
Protein urine present 29.15 10.36 60 123511 5168 34828192
Epstein-Barr virus infection reactivation 29.13 10.36 27 123544 1077 34832283
Fungal skin infection 29.09 10.36 41 123530 2593 34830767
Immunosuppression 29.05 10.36 67 123504 6237 34827123
Renal graft infection 28.94 10.36 16 123555 275 34833085
Respiratory arrest 28.77 10.36 34 123537 28009 34805351
Peripheral swelling 28.72 10.36 156 123415 76385 34756975
Pemphigus 28.61 10.36 32 123539 1599 34831761
Nightmare 28.08 10.36 8 123563 14383 34818977
Bacteraemia 28.07 10.36 141 123430 19576 34813784
Low birth weight baby 27.99 10.36 76 123495 7829 34825531
Contraindicated product administered 27.95 10.36 21 123550 21460 34811900
Pain in extremity 27.93 10.36 299 123272 126214 34707146
Respiratory tract infection fungal 27.81 10.36 22 123549 705 34832655
Dyskinesia 27.79 10.36 23 123548 22390 34810970
Pneumocephalus 27.79 10.36 13 123558 154 34833206
Depressed mood 27.66 10.36 17 123554 19300 34814060
Osteoporosis 27.59 10.36 103 123468 12565 34820795
Bronchopneumopathy 27.48 10.36 19 123552 493 34832867
Escherichia sepsis 27.43 10.36 55 123516 4649 34828711
Quadriplegia 27.29 10.36 33 123538 1794 34831566
Accidental exposure to product 27.14 10.36 6 123565 12796 34820564
Accidental overdose 27.11 10.36 19 123552 20121 34813239
Abdominal discomfort 27.09 10.36 114 123457 59721 34773639
Wheezing 27.03 10.36 67 123504 41335 34792025
Growth retardation 26.99 10.36 33 123538 1815 34831545
Treatment noncompliance 26.81 10.36 36 123535 28064 34805296
Gastrointestinal candidiasis 26.72 10.36 13 123558 169 34833191
Polyomavirus viraemia 26.67 10.36 24 123547 921 34832439
Intentional product use issue 26.63 10.36 326 123245 59490 34773870
Pruritus 26.56 10.36 348 123223 141633 34691727
Laboratory test abnormal 26.45 10.36 20 123551 20371 34812989
Mobility decreased 26.38 10.36 41 123530 30087 34803273
Angiosarcoma 26.27 10.36 15 123556 275 34833085
Scopulariopsis infection 26.25 10.36 11 123560 98 34833262
Obliterative bronchiolitis 26.24 10.36 27 123544 1226 34832134
Enterococcus test positive 26.02 10.36 25 123546 1044 34832316
Alveolar proteinosis 25.97 10.36 18 123553 469 34832891
Ureteric stenosis 25.82 10.36 26 123545 1150 34832210
Full blood count decreased 25.78 10.36 16 123555 18072 34815288
Abdominal abscess 25.77 10.36 50 123521 4125 34829235
Viral haemorrhagic cystitis 25.75 10.36 26 123545 1154 34832206
Splenic embolism 25.62 10.36 13 123558 186 34833174
Viral sepsis 25.59 10.36 11 123560 105 34833255
Agitation 25.59 10.36 110 123461 57289 34776071
Leukocytosis 25.54 10.36 159 123412 23906 34809454
Hepatic failure 25.49 10.36 209 123362 34322 34799038
Pneumonia bacterial 25.42 10.36 96 123475 11776 34821584
Staphylococcal mediastinitis 25.40 10.36 9 123562 48 34833312
Poisoning 25.38 10.36 6 123565 12220 34821140
Lupus nephritis 25.26 10.36 16 123555 357 34833003
American trypanosomiasis 25.20 10.36 14 123557 243 34833117
Limbic encephalitis 25.11 10.36 17 123554 426 34832934
Hypogammaglobulinaemia 25.03 10.36 72 123499 7668 34825692
Disseminated blastomycosis 24.80 10.36 12 123559 154 34833206
Cholelithiasis 24.66 10.36 23 123548 21125 34812235
Dry mouth 24.60 10.36 43 123528 30122 34803238
Graft infection 24.46 10.36 17 123554 445 34832915
Bifidobacterium infection 24.43 10.36 8 123563 32 34833328
Gastroenteritis Escherichia coli 24.34 10.36 16 123555 381 34832979
Injection site erythema 24.18 10.36 13 123558 15886 34817474
Medication error 24.14 10.36 33 123538 25532 34807828
Graft loss 24.08 10.36 22 123549 861 34832499
Reticulocytosis 24.08 10.36 14 123557 266 34833094
Cutaneous malacoplakia 24.07 10.36 10 123561 87 34833273
Neuroleptic malignant syndrome 24.03 10.36 17 123554 17917 34815443
Lymphocytosis 23.97 10.36 37 123534 2540 34830820
Enterovirus infection 23.89 10.36 23 123548 963 34832397
Dyspnoea exertional 23.84 10.36 76 123495 43203 34790157
Herpes zoster 23.70 10.36 205 123366 34194 34799166
Cryptococcal meningoencephalitis 23.69 10.36 11 123560 128 34833232
Unresponsive to stimuli 23.68 10.36 38 123533 27531 34805829
Swollen tongue 23.63 10.36 11 123560 14594 34818766
Contusion 23.62 10.36 59 123512 36305 34797055
Lymphangitis 23.57 10.36 18 123553 547 34832813
Tuberculosis 23.26 10.36 75 123496 8502 34824858
Blood beta-D-glucan increased 23.22 10.36 16 123555 413 34832947
Incorrect dose administered 23.13 10.36 70 123501 40445 34792915
B-cell lymphoma 23.07 10.36 49 123522 4314 34829046
Herpes simplex hepatitis 23.04 10.36 10 123561 98 34833262
Epstein-Barr virus associated lymphoma 22.98 10.36 19 123552 649 34832711
Product substitution issue 22.94 10.36 4 123567 10091 34823269
Hepatic artery thrombosis 22.93 10.36 13 123558 235 34833125
Diabetes mellitus 22.87 10.36 260 123311 46613 34786747
Venoocclusive liver disease 22.83 10.36 71 123500 7895 34825465
Adverse event 22.64 10.36 20 123551 18857 34814503
Herpes virus infection 22.60 10.36 38 123533 2804 34830556
Hyperkalaemia 22.55 10.36 148 123423 69241 34764119
Sideroblastic anaemia 22.41 10.36 13 123558 246 34833114
Malignant neoplasm progression 22.40 10.36 201 123370 87845 34745515
Dysgeusia 22.31 10.36 37 123534 26460 34806900
Hypersomnia 22.25 10.36 8 123563 12399 34820961
Herpes zoster meningoencephalitis 22.23 10.36 14 123557 309 34833051
Drug interaction 22.06 10.36 619 122952 225327 34608033
Hypertension 22.05 10.36 635 122936 135808 34697552
Drug intolerance 22.02 10.36 122 123449 59448 34773912
Adverse drug reaction 22.01 10.36 44 123527 29298 34804062
Mycobacterial infection 21.96 10.36 34 123537 2340 34831020
Intestinal ischaemia 21.90 10.36 69 123502 7725 34825635
Monocytopenia 21.90 10.36 9 123562 76 34833284
Herpes simplex viraemia 21.90 10.36 9 123562 76 34833284
Blood creatine phosphokinase increased 21.86 10.36 83 123488 44774 34788586
Hypophagia 21.70 10.36 32 123539 23990 34809370
Enterococcal bacteraemia 21.66 10.36 30 123541 1867 34831493
Intra-abdominal haemorrhage 21.64 10.36 34 123537 2370 34830990
Exposure during pregnancy 21.52 10.36 3 123568 8931 34824429
B-lymphocyte count decreased 21.52 10.36 18 123553 625 34832735
Klebsiella sepsis 21.46 10.36 31 123540 2006 34831354
Asthma 21.39 10.36 78 123493 42578 34790782
Dyspepsia 21.30 10.36 63 123508 36669 34796691
Necrosis 21.25 10.36 56 123515 5667 34827693
Multiple-drug resistance 21.25 10.36 53 123518 5186 34828174
Multi-organ disorder 21.24 10.36 24 123547 1213 34832147
Haemodynamic instability 21.22 10.36 78 123493 9445 34823915
Epstein-Barr virus test positive 21.19 10.36 17 123554 556 34832804
Miosis 21.18 10.36 4 123567 9531 34823829
Glomerulonephritis rapidly progressive 21.16 10.36 18 123553 640 34832720
Orthostatic hypotension 21.08 10.36 37 123534 25882 34807478
Listeriosis 21.07 10.36 22 123549 1016 34832344
Bladder cancer 21.07 10.36 16 123555 16262 34817098
Blood sodium decreased 21.00 10.36 16 123555 16235 34817125
Vaccination failure 20.99 10.36 23 123548 1123 34832237
Diaphragmatic injury 20.83 10.36 10 123561 126 34833234
Injection site reaction 20.80 10.36 10 123561 13023 34820337
Psoriasis 20.79 10.36 69 123502 38743 34794617
Torulopsis infection 20.72 10.36 6 123565 14 34833346
Abdominal pain 20.70 10.36 431 123140 163187 34670173
Cystitis escherichia 20.59 10.36 11 123560 176 34833184
Dermatophytosis 20.55 10.36 12 123559 230 34833130
Cavernous sinus thrombosis 20.48 10.36 11 123560 178 34833182
Shock haemorrhagic 20.45 10.36 87 123484 11267 34822093
Red blood cell schistocytes present 20.41 10.36 12 123559 233 34833127
Mycotic endophthalmitis 20.40 10.36 9 123562 92 34833268
Irritability 20.31 10.36 35 123536 24655 34808705
Trichophytosis 20.25 10.36 13 123558 297 34833063
Cytomegalovirus gastritis 20.23 10.36 12 123559 237 34833123
Rhinovirus infection 20.15 10.36 46 123525 4253 34829107
Graft complication 20.09 10.36 14 123557 368 34832992
Encephalitis 20.06 10.36 64 123507 7213 34826147
Loss of consciousness 20.04 10.36 191 123380 82476 34750884
Atypical mycobacterial pneumonia 20.03 10.36 10 123561 138 34833222
Cerebral aspergillosis 19.99 10.36 25 123546 1407 34831953
Tumefactive multiple sclerosis 19.96 10.36 7 123564 36 34833324
Sedation 19.95 10.36 27 123544 20979 34812381
Amoebiasis 19.95 10.36 8 123563 63 34833297
Toxic epidermal necrolysis 19.92 10.36 138 123433 21508 34811852
Pneumonia klebsiella 19.74 10.36 39 123532 3261 34830099
Cardiac arrest 19.73 10.36 231 123340 95928 34737432
Immune reconstitution inflammatory syndrome 19.73 10.36 72 123499 8687 34824673
Mixed liver injury 19.72 10.36 36 123535 2837 34830523
White blood cell count decreased 19.70 10.36 229 123342 95216 34738144
Tularaemia 19.59 10.36 9 123562 102 34833258
Fluid retention 19.58 10.36 41 123530 26846 34806514
Endocarditis 19.56 10.36 59 123512 6452 34826908
Lymphoproliferative disorder 19.48 10.36 35 123536 2724 34830636
Neutrophil percentage increased 19.46 10.36 28 123543 1805 34831555
Lymphocele 19.44 10.36 24 123547 1333 34832027
Bordetella infection 19.43 10.36 9 123562 104 34833256
Disturbance in attention 19.38 10.36 39 123532 25906 34807454
Blood pressure decreased 19.31 10.36 105 123466 51410 34781950
Kidney rupture 19.30 10.36 11 123560 201 34833159
Glycosylated haemoglobin increased 19.25 10.36 8 123563 11352 34822008
West Nile viral infection 19.19 10.36 18 123553 729 34832631
Electrocardiogram QT prolonged 19.17 10.36 77 123494 40875 34792485
Vasculitis 19.16 10.36 85 123486 11211 34822149
Adenoviral haemorrhagic cystitis 19.08 10.36 14 123557 400 34832960
Urine abnormality 19.02 10.36 29 123542 1970 34831390
Hepatitis A 18.90 10.36 15 123556 483 34832877
Secondary immunodeficiency 18.90 10.36 14 123557 406 34832954
Akathisia 18.90 10.36 3 123568 8106 34825254
Demodicidosis 18.87 10.36 11 123560 210 34833150
Gastrointestinal perforation 18.85 10.36 42 123529 3821 34829539
Bronchopleural fistula 18.77 10.36 15 123556 488 34832872
Complications of transplant surgery 18.58 10.36 15 123556 495 34832865
Pharyngeal paraesthesia 18.55 10.36 17 123554 668 34832692
Hypoaesthesia 18.51 10.36 134 123437 61310 34772050
Necrosis ischaemic 18.47 10.36 12 123559 280 34833080
Inflammatory marker increased 18.47 10.36 49 123522 4979 34828381
Salivary hypersecretion 18.43 10.36 4 123567 8640 34824720
Cytomegalovirus gastrointestinal infection 18.42 10.36 11 123560 220 34833140
Bursitis infective 18.38 10.36 16 123555 587 34832773
Pyelonephritis acute 18.37 10.36 29 123542 2030 34831330
Therapy partial responder 18.35 10.36 75 123496 9541 34823819
Coma 18.31 10.36 91 123480 45587 34787773
Gonococcal infection 18.28 10.36 7 123564 48 34833312
Psoriatic arthropathy 18.25 10.36 26 123545 19772 34813588
Cytomegalovirus nephritis 18.23 10.36 9 123562 121 34833239
Cryptitis 18.21 10.36 11 123560 225 34833135
Listeria sepsis 18.18 10.36 10 123561 170 34833190
Injection site swelling 18.16 10.36 9 123562 11518 34821842
Heart transplant rejection 18.00 10.36 22 123549 1209 34832151
General physical health deterioration 18.00 10.36 332 123239 127937 34705423
Superinfection bacterial 18.00 10.36 19 123552 889 34832471
Central nervous system lesion 17.96 10.36 57 123514 6406 34826954
Gastritis fungal 17.95 10.36 8 123563 84 34833276
Smooth muscle cell neoplasm 17.93 10.36 10 123561 175 34833185
Peritonitis 17.91 10.36 109 123462 16256 34817104
Fungal endocarditis 17.85 10.36 13 123558 367 34832993
Device related sepsis 17.84 10.36 36 123535 3057 34830303
Adenoviral hepatitis 17.74 10.36 15 123556 529 34832831
Disseminated trichosporonosis 17.69 10.36 7 123564 53 34833307
Episcleritis 17.68 10.36 10 123561 180 34833180
Blastomycosis 17.66 10.36 14 123557 450 34832910
Treatment failure 17.64 10.36 247 123324 46450 34786910
Encephalitis fungal 17.63 10.36 10 123561 181 34833179
Vision blurred 17.61 10.36 93 123478 45870 34787490
Urine analysis abnormal 17.60 10.36 28 123543 1973 34831387
Seronegative arthritis 17.57 10.36 20 123551 1019 34832341
IgA nephropathy 17.55 10.36 22 123549 1241 34832119
Blindness cortical 17.46 10.36 13 123558 380 34832980
Blood pressure diastolic decreased 17.41 10.36 71 123500 9023 34824337
Marrow hyperplasia 17.36 10.36 21 123550 1142 34832218
Neck pain 17.36 10.36 40 123531 25309 34808051
Intentional self-injury 17.24 10.36 14 123557 13757 34819603
Thrombosis 17.23 10.36 106 123465 50352 34783008
Necrotising oesophagitis 17.22 10.36 15 123556 551 34832809
Arterial spasm 17.16 10.36 8 123563 94 34833266
Blood immunoglobulin M decreased 17.14 10.36 14 123557 470 34832890
Lower gastrointestinal haemorrhage 17.11 10.36 6 123565 9446 34823914
Thrombocytopenia 17.10 10.36 695 122876 155552 34677808
Leishmaniasis 17.07 10.36 12 123559 320 34833040
Aplasia pure red cell 16.97 10.36 54 123517 6078 34827282
Therapy cessation 16.96 10.36 21 123550 16952 34816408
Cardio-respiratory arrest 16.91 10.36 120 123451 55153 34778207
Herpes simplex colitis 16.88 10.36 5 123566 13 34833347
Skin discolouration 16.88 10.36 23 123548 17822 34815538
Post procedural urine leak 16.85 10.36 9 123562 144 34833216
Urinary tract infection bacterial 16.78 10.36 27 123544 1921 34831439
Viral cardiomyopathy 16.78 10.36 6 123565 33 34833327
Renal impairment 16.70 10.36 445 123126 94068 34739292
Oesophageal carcinoma 16.68 10.36 6 123565 9298 34824062
Atrial septal defect 16.64 10.36 3 123568 7389 34825971
Chemotherapeutic drug level above therapeutic 16.62 10.36 5 123566 14 34833346
Subcapsular renal haematoma 16.58 10.36 13 123558 411 34832949
Stenotrophomonas infection 16.50 10.36 28 123543 2082 34831278
Brain abscess 16.41 10.36 35 123536 3090 34830270
Injection site haemorrhage 16.36 10.36 7 123564 9761 34823599
Respiratory depression 16.34 10.36 20 123551 16225 34817135
Ageusia 16.31 10.36 8 123563 10300 34823060
Herpes oesophagitis 16.26 10.36 9 123562 155 34833205
Meningitis fungal 16.24 10.36 8 123563 107 34833253
Morganella infection 16.22 10.36 14 123557 508 34832852
Visceral leishmaniasis 16.21 10.36 15 123556 597 34832763
Intestine transplant rejection 16.21 10.36 6 123565 37 34833323
Bacterial translocation 16.20 10.36 12 123559 348 34833012
Cutaneous nocardiosis 16.11 10.36 9 123562 158 34833202
Sarcopenia 16.05 10.36 13 123558 431 34832929
Accelerated idioventricular rhythm 15.96 10.36 9 123562 161 34833199
Organising pneumonia 15.95 10.36 52 123519 5927 34827433
Neuromyotonia 15.94 10.36 6 123565 39 34833321
Stupor 15.90 10.36 33 123538 2858 34830502
Haematopoietic stem cell mobilisation 15.81 10.36 9 123562 164 34833196
Amnesia 15.81 10.36 45 123526 26518 34806842
Seizure 15.79 10.36 268 123303 104589 34728771
Pleural mass 15.75 10.36 7 123564 73 34833287
Hepatic cirrhosis 15.70 10.36 23 123548 17291 34816069
Haemolytic anaemia 15.67 10.36 76 123495 10403 34822957
Febrile bone marrow aplasia 15.64 10.36 64 123507 8145 34825215
Disseminated tuberculosis 15.60 10.36 28 123543 2177 34831183
Pulmonary haemorrhage 15.60 10.36 75 123496 10229 34823131
Nephrotic syndrome 15.59 10.36 59 123512 7244 34826116
Pseudomonal sepsis 15.58 10.36 37 123534 3510 34829850
Urobilinogen urine increased 15.57 10.36 12 123559 370 34832990
Palmar-plantar erythrodysaesthesia syndrome 15.54 10.36 22 123549 16773 34816587
Drug withdrawal syndrome 15.52 10.36 29 123542 19805 34813555
Herpes zoster cutaneous disseminated 15.48 10.36 9 123562 171 34833189
Megacolon 15.47 10.36 25 123546 1785 34831575
Peritoneal candidiasis 15.47 10.36 5 123566 19 34833341
Hepatitis E 15.42 10.36 27 123544 2059 34831301
Chimerism 15.41 10.36 10 123561 233 34833127
Cerebral venous thrombosis 15.34 10.36 16 123555 738 34832622
Steroid withdrawal syndrome 15.29 10.36 10 123561 236 34833124
Respiratory distress 15.28 10.36 193 123378 35472 34797888
Palpitations 15.26 10.36 81 123490 39905 34793455
Arteriosclerosis coronary artery 15.25 10.36 13 123558 12472 34820888
Abnormal dreams 15.18 10.36 4 123567 7574 34825786
Enteritis 15.14 10.36 63 123508 8079 34825281
Gastrointestinal ulcer 15.13 10.36 24 123547 1687 34831673
Abdominal infection 15.12 10.36 25 123546 1820 34831540
C-reactive protein increased 15.09 10.36 272 123299 53826 34779534
Encephalopathy 15.07 10.36 191 123380 35128 34798232
Chronic obstructive pulmonary disease 15.06 10.36 106 123465 48812 34784548
Lymphocyte percentage decreased 14.99 10.36 27 123544 2105 34831255
Ureteric anastomosis complication 14.99 10.36 6 123565 47 34833313
Respiratory disorder 14.98 10.36 118 123453 19146 34814214
Neuromyelitis optica spectrum disorder 14.98 10.36 8 123563 128 34833232
Spermatozoa progressive motility decreased 14.98 10.36 8 123563 128 34833232
Product storage error 14.97 10.36 5 123566 8117 34825243
Jejunal perforation 14.97 10.36 10 123561 245 34833115
Venoocclusive disease 14.93 10.36 32 123539 2835 34830525
Encephalitis brain stem 14.88 10.36 7 123564 84 34833276
Disseminated varicella zoster vaccine virus infection 14.88 10.36 6 123565 48 34833312
Activated partial thromboplastin time shortened 14.87 10.36 13 123558 480 34832880
Pancreas transplant rejection 14.86 10.36 9 123562 185 34833175
Crystal urine present 14.82 10.36 13 123558 482 34832878
Lung transplant rejection 14.69 10.36 16 123555 776 34832584
Uraemic encephalopathy 14.67 10.36 11 123560 325 34833035
Vasculitis gastrointestinal 14.67 10.36 6 123565 50 34833310
Angina pectoris 14.66 10.36 59 123512 31304 34802056
Herpes simplex oesophagitis 14.65 10.36 9 123562 190 34833170
Nocturia 14.60 10.36 9 123562 10201 34823159
Sleep disorder 14.57 10.36 60 123511 31628 34801732
Chronic papillomatous dermatitis 14.56 10.36 6 123565 51 34833309
Arteritis coronary 14.56 10.36 6 123565 51 34833309
Liver function test 14.56 10.36 6 123565 51 34833309
Diastolic hypotension 14.56 10.36 6 123565 51 34833309
Gynaecomastia 14.52 10.36 9 123562 10171 34823189
Optic atrophy 14.46 10.36 17 123554 897 34832463
Arterial rupture 14.42 10.36 13 123558 500 34832860
Acute myocardial infarction 14.38 10.36 121 123450 53598 34779762
Eschar 14.29 10.36 15 123556 697 34832663
Candida sepsis 14.26 10.36 20 123551 1259 34832101
Faeces discoloured 14.25 10.36 19 123552 14859 34818501
Anti-neutrophil cytoplasmic antibody positive vasculitis 14.24 10.36 17 123554 912 34832448
Abdominal distension 14.24 10.36 135 123436 58357 34775003
Optic nerve compression 14.23 10.36 4 123567 8 34833352
Paranoia 14.22 10.36 13 123558 12055 34821305
Coronary artery dilatation 14.21 10.36 5 123566 26 34833334
Acne fulminans 14.20 10.36 9 123562 201 34833159
Encephalitis cytomegalovirus 14.19 10.36 14 123557 604 34832756
Arthritis fungal 14.19 10.36 7 123564 94 34833266
Systemic inflammatory response syndrome 14.15 10.36 54 123517 6655 34826705
Cardiac failure 14.14 10.36 232 123339 91016 34742344
Haemoperitoneum 14.11 10.36 24 123547 1788 34831572
Bacterial infection 14.09 10.36 106 123465 16957 34816403
Femoral nerve palsy 14.08 10.36 6 123565 56 34833304
Muscle rigidity 14.05 10.36 10 123561 10508 34822852
Therapeutic product effect decreased 14.04 10.36 69 123502 34674 34798686
Rash 14.02 10.36 644 122927 222108 34611252
Foetal growth restriction 14 10.36 39 123532 4078 34829282
Panic attack 13.93 10.36 8 123563 9424 34823936
Eye luxation 13.91 10.36 4 123567 9 34833351
Meningitis cryptococcal 13.89 10.36 28 123543 2376 34830984
Ophthalmoplegia 13.84 10.36 24 123547 1816 34831544
Pneumonia escherichia 13.84 10.36 12 123559 438 34832922
Dehiscence 13.68 10.36 7 123564 102 34833258
Pericarditis fungal 13.67 10.36 8 123563 154 34833206
Glomerulonephropathy 13.67 10.36 9 123562 215 34833145
Renal haemorrhage 13.67 10.36 21 123550 1436 34831924
Wolff-Parkinson-White syndrome 13.60 10.36 9 123562 217 34833143
Pneumonia adenoviral 13.55 10.36 11 123560 366 34832994
Chronic graft versus host disease in eye 13.50 10.36 7 123564 105 34833255
Blood immunoglobulin G decreased 13.49 10.36 21 123550 1452 34831908
Peliosis hepatis 13.46 10.36 6 123565 63 34833297
Pleuropericarditis 13.42 10.36 9 123562 222 34833138
Immune thrombocytopenia 13.41 10.36 66 123505 9086 34824274
Empyema 13.40 10.36 33 123538 3203 34830157
Eye abscess 13.40 10.36 8 123563 160 34833200
Growth disorder 13.35 10.36 5 123566 32 34833328
Herpes simplex meningoencephalitis 13.35 10.36 4 123567 11 34833349
Arteriovenous fistula 13.33 10.36 18 123553 1093 34832267
Intestinal intraepithelial lymphocytes increased 13.31 10.36 8 123563 162 34833198
Flatulence 13.30 10.36 35 123536 21163 34812197
Scedosporium infection 13.29 10.36 16 123555 866 34832494
Hospice care 13.28 10.36 4 123567 6936 34826424
Memory impairment 13.27 10.36 94 123477 43224 34790136
Kaposi's sarcoma 13.27 10.36 16 123555 867 34832493
Pneumonia necrotising 13.26 10.36 15 123556 759 34832601
Oral bacterial infection 13.22 10.36 5 123566 33 34833327
Human herpesvirus 6 infection reactivation 13.18 10.36 8 123563 165 34833195
Biopsy lymph gland 13.14 10.36 6 123565 67 34833293
Hypocalcaemia 13.13 10.36 43 123528 24246 34809114
Cardiogenic shock 13.13 10.36 49 123522 26569 34806791
Neuropathy peripheral 13.13 10.36 211 123360 83052 34750308
Atypical mycobacterial infection 13.13 10.36 16 123555 877 34832483
Prescribed overdose 13.11 10.36 11 123560 10636 34822724
Appendicitis 13.11 10.36 20 123551 14787 34818573
Urinary fistula 13.10 10.36 7 123564 112 34833248
Acute endocarditis 13.09 10.36 5 123566 34 34833326
Ovarian cancer metastatic 13.09 10.36 4 123567 12 34833348
Fungal abscess central nervous system 13.05 10.36 7 123564 113 34833247
Post procedural bile leak 13.01 10.36 10 123561 307 34833053
Exophthalmos 13.01 10.36 13 123558 570 34832790
Nephrolithiasis 12.99 10.36 59 123512 30274 34803086
Haemorrhagic necrotic pancreatitis 12.97 10.36 8 123563 170 34833190
Swelling 12.95 10.36 92 123479 42274 34791086
Myoclonus 12.93 10.36 20 123551 14705 34818655
Ventricular extrasystoles 12.92 10.36 14 123557 11994 34821366
Pneumonia influenzal 12.92 10.36 21 123550 1507 34831853
Infection masked 12.91 10.36 6 123565 70 34833290
Hyponatraemia 12.89 10.36 210 123361 82481 34750879
Capillaritis 12.89 10.36 7 123564 116 34833244
Gastric disorder 12.85 10.36 15 123556 12426 34820934
Dizziness postural 12.84 10.36 3 123568 6161 34827199
Blood pressure diastolic increased 12.78 10.36 43 123528 4982 34828378
Conus medullaris syndrome 12.73 10.36 5 123566 37 34833323
Infective tenosynovitis 12.68 10.36 6 123565 73 34833287
Fear 12.68 10.36 11 123560 10465 34822895
Meconium peritonitis 12.63 10.36 4 123567 14 34833346
Palatal ulcer 12.62 10.36 5 123566 38 34833322
Central nervous system vasculitis 12.57 10.36 12 123559 497 34832863
Amoebic dysentery 12.51 10.36 5 123566 39 34833321
Lymphocytic infiltration 12.49 10.36 14 123557 701 34832659
Vitamin B1 decreased 12.44 10.36 10 123561 328 34833032
Shock symptom 12.42 10.36 7 123564 125 34833235
Serum sickness 12.40 10.36 24 123547 1976 34831384
Toxoplasmosis 12.39 10.36 19 123552 1297 34832063
Granulomatous liver disease 12.39 10.36 13 123558 604 34832756
Drug eruption 12.37 10.36 33 123538 19865 34813495
Erosive duodenitis 12.34 10.36 22 123549 1702 34831658
Disseminated toxoplasmosis 12.33 10.36 6 123565 78 34833282
Diarrhoea haemorrhagic 12.31 10.36 52 123519 6712 34826648
Acute kidney injury 12.31 10.36 920 122651 304068 34529292
Epididymitis 12.30 10.36 27 123544 2432 34830928
Pyelonephritis 12.28 10.36 49 123522 6166 34827194
Bronchomalacia 12.28 10.36 7 123564 128 34833232
Granuloma 12.26 10.36 32 123539 3219 34830141
Muscle twitching 12.24 10.36 11 123560 10287 34823073
Infectious pleural effusion 12.21 10.36 27 123544 2443 34830917
Renal artery perforation 12.21 10.36 4 123567 16 34833344
Carotid artery insufficiency 12.21 10.36 4 123567 16 34833344
Inadequate aseptic technique in use of product 12.21 10.36 4 123567 16 34833344
Porphyria acute 12.21 10.36 10 123561 337 34833023
Trichosporon infection 12.19 10.36 14 123557 720 34832640
Ventricular fibrillation 12.16 10.36 41 123530 22913 34810447
Hepatitis cholestatic 12.14 10.36 58 123513 7889 34825471
Congenital cardiovascular anomaly 12.12 10.36 8 123563 192 34833168
Electrocardiogram abnormal 12.08 10.36 9 123562 9238 34824122
Nodular regenerative hyperplasia 12.04 10.36 16 123555 957 34832403
Hypergammaglobulinaemia 12.03 10.36 9 123562 265 34833095
Serratia sepsis 12.00 10.36 6 123565 83 34833277
Viral load abnormal 12.00 10.36 6 123565 83 34833277
Radiotherapy to brain 11.99 10.36 5 123566 44 34833316
Semen volume decreased 11.99 10.36 10 123561 346 34833014
Pollakiuria 11.95 10.36 33 123538 19641 34813719
Gastroenteritis rotavirus 11.94 10.36 8 123563 197 34833163
Fungal sepsis 11.93 10.36 15 123556 849 34832511
Renal tubular injury 11.91 10.36 16 123555 967 34832393
Autoimmune haemolytic anaemia 11.91 10.36 39 123532 4457 34828903
Neonatal multi-organ failure 11.88 10.36 3 123568 3 34833357
Community acquired infection 11.88 10.36 3 123568 3 34833357
Papillary muscle rupture 11.88 10.36 3 123568 3 34833357
Galactosaemia 11.88 10.36 3 123568 3 34833357
Subdural haematoma 11.86 10.36 35 123536 20386 34812974
Osteomyelitis blastomyces 11.84 10.36 4 123567 18 34833342
Phaeohyphomycotic brain abscess 11.79 10.36 5 123566 46 34833314
Aortic pseudoaneurysm 11.79 10.36 5 123566 46 34833314
Rash maculo-papular 11.78 10.36 153 123418 28298 34805062
Mucosal ulceration 11.76 10.36 16 123555 979 34832381
Gait inability 11.75 10.36 36 123535 20722 34812638
Brain herniation 11.74 10.36 36 123535 3972 34829388
Reversible cerebral vasoconstriction syndrome 11.72 10.36 11 123560 446 34832914
Tardive dyskinesia 11.71 10.36 3 123568 5787 34827573
Acute disseminated encephalomyelitis 11.69 10.36 6 123565 88 34833272
Inhibin B 11.67 10.36 4 123567 19 34833341
Lip haemorrhage 11.65 10.36 14 123557 756 34832604
Arthralgia 11.64 10.36 487 123084 169554 34663806
Acinetobacter test positive 11.64 10.36 7 123564 142 34833218
ADAMTS13 activity decreased 11.63 10.36 6 123565 89 34833271
Septic pulmonary embolism 11.61 10.36 5 123566 48 34833312
Thyroiditis subacute 11.61 10.36 5 123566 48 34833312
Neutrophil count decreased 11.58 10.36 120 123451 50984 34782376
Haptoglobin decreased 11.57 10.36 12 123559 550 34832810
Vitritis 11.56 10.36 15 123556 876 34832484
Autoimmune colitis 11.52 10.36 16 123555 998 34832362
Angioedema 11.50 10.36 81 123490 37293 34796067
Interferon gamma release assay positive 11.50 10.36 4 123567 20 34833340
Infective aortitis 11.50 10.36 4 123567 20 34833340
Escherichia urinary tract infection 11.48 10.36 33 123538 3513 34829847
Cold sweat 11.48 10.36 11 123560 9976 34823384
Fungal peritonitis 11.46 10.36 14 123557 769 34832591
Colorectal adenocarcinoma 11.46 10.36 8 123563 211 34833149
Bacillus infection 11.44 10.36 9 123562 286 34833074
Corneal endotheliitis 11.43 10.36 5 123566 50 34833310
Sexual dysfunction 11.41 10.36 4 123567 6299 34827061
Fibrin D dimer increased 11.41 10.36 37 123534 4207 34829153
Splenic infection fungal 11.40 10.36 6 123565 93 34833267
Clostridium colitis 11.39 10.36 18 123553 1261 34832099
Angiocentric lymphoma 11.39 10.36 9 123562 288 34833072
Head injury 11.38 10.36 30 123541 18130 34815230
Delirium 11.37 10.36 100 123471 43891 34789469
Skin exfoliation 11.37 10.36 54 123517 27378 34805982
Microscopic polyangiitis 11.36 10.36 8 123563 214 34833146
Body temperature decreased 11.35 10.36 82 123489 12952 34820408
Hypertensive encephalopathy 11.33 10.36 10 123561 374 34832986
Blood potassium increased 11.31 10.36 26 123545 16469 34816891
Rib fracture 11.31 10.36 21 123550 14379 34818981
Anuria 11.26 10.36 69 123502 10316 34823044
Vitello-intestinal duct remnant 11.26 10.36 7 123564 151 34833209
Actinomycosis 11.24 10.36 11 123560 470 34832890
Nephritis 11.24 10.36 26 123545 2425 34830935
Adenomatous polyposis coli 11.18 10.36 7 123564 153 34833207
Oral herpes 11.17 10.36 44 123527 5503 34827857
Hemianopia 11.13 10.36 13 123558 681 34832679
Eosinophil percentage decreased 11.12 10.36 6 123565 98 34833262
Autoimmune thyroiditis 11.12 10.36 17 123554 1157 34832203
Complication of device removal 11.09 10.36 5 123566 54 34833306
Restless legs syndrome 11.09 10.36 8 123563 8346 34825014
Optic nerve operation 11.07 10.36 11 123560 479 34832881
Lipoma 11.06 10.36 21 123550 1705 34831655
Anaemia 11.04 10.36 694 122877 232641 34600719
Small intestinal perforation 11.04 10.36 24 123547 2147 34831213
Myocarditis infectious 11.04 10.36 4 123567 23 34833337
Pseudopolyposis 11.01 10.36 5 123566 55 34833305
Needle issue 11.01 10.36 4 123567 6161 34827199
Mouth ulceration 11.00 10.36 76 123495 11834 34821526
Urinary retention 10.99 10.36 79 123492 36209 34797151
Abdominal pain upper 10.99 10.36 182 123389 71308 34762052
Acinetobacter bacteraemia 10.98 10.36 7 123564 158 34833202
Chest wall abscess 10.98 10.36 7 123564 158 34833202
Obstructive airways disorder 10.97 10.36 24 123547 15470 34817890
Sputum purulent 10.95 10.36 11 123560 485 34832875
Injury 10.93 10.36 37 123534 20650 34812710
Underdose 10.91 10.36 20 123551 13760 34819600
Platelet count decreased 10.90 10.36 331 123240 119386 34713974
Abscess sterile 10.90 10.36 4 123567 24 34833336
Periventricular haemorrhage neonatal 10.90 10.36 4 123567 24 34833336
Adrenal insufficiency 10.90 10.36 86 123485 13961 34819399
Hepatic cancer 10.88 10.36 8 123563 8267 34825093
Osteitis 10.88 10.36 20 123551 1584 34831776
Hyperplasia 10.85 10.36 12 123559 592 34832768
Retinal scar 10.85 10.36 9 123562 309 34833051
Infective aneurysm 10.84 10.36 12 123559 593 34832767
Dental caries 10.81 10.36 38 123533 4501 34828859
Torsade de pointes 10.81 10.36 6 123565 7203 34826157
Gastrooesophageal reflux disease 10.80 10.36 84 123487 37840 34795520
Epistaxis 10.79 10.36 143 123428 58108 34775252
Tooth injury 10.79 10.36 17 123554 1188 34832172
Status epilepticus 10.78 10.36 79 123492 12535 34820825
Cerebellar ataxia 10.77 10.36 16 123555 1062 34832298
Hypocomplementaemia 10.76 10.36 4 123567 25 34833335
Body height below normal 10.74 10.36 8 123563 234 34833126
Erythema infectiosum 10.71 10.36 7 123564 165 34833195
Clostridium difficile infection 10.69 10.36 108 123463 18790 34814570
Pancreatitis 10.68 10.36 87 123484 38804 34794556
Acute pulmonary histoplasmosis 10.68 10.36 7 123564 166 34833194
Pharyngeal oedema 10.67 10.36 4 123567 6043 34827317
Corynebacterium bacteraemia 10.67 10.36 3 123568 6 34833354
Herpes simplex sepsis 10.67 10.36 3 123568 6 34833354
Blood glucose decreased 10.67 10.36 19 123552 13218 34820142
Chorioretinal folds 10.67 10.36 3 123568 6 34833354
Diffuse mesangial sclerosis 10.63 10.36 5 123566 60 34833300
Acanthamoeba infection 10.58 10.36 10 123561 409 34832951
Norovirus infection 10.57 10.36 7 123564 169 34833191
Pancytopenia 10.57 10.36 424 123147 94733 34738627
Substance abuse 10.56 10.36 7 123564 7634 34825726
Premature baby 10.54 10.36 111 123460 19522 34813838
Blood creatinine increased 10.50 10.36 423 123148 94553 34738807
Meningioma malignant 10.50 10.36 4 123567 27 34833333
Cytomegalovirus duodenitis 10.49 10.36 5 123566 62 34833298
Coombs direct test positive 10.49 10.36 9 123562 324 34833036
Bundle branch block left 10.48 10.36 4 123567 5975 34827385
Hypercapnia 10.46 10.36 36 123535 4219 34829141
Tubulointerstitial nephritis 10.42 10.36 117 123454 20907 34812453
Pelvic venous thrombosis 10.41 10.36 12 123559 620 34832740
Investigation abnormal 10.40 10.36 11 123560 516 34832844
Aspergilloma 10.39 10.36 9 123562 328 34833032
Subperiosteal abscess 10.38 10.36 4 123567 28 34833332

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 1604.26 9.44 7000 281815 900215 78555358
Cytomegalovirus infection 1520.34 9.44 1250 287565 41394 79414179
Product use in unapproved indication 956.85 9.44 2510 286305 247849 79207724
Drug ineffective for unapproved indication 830.84 9.44 976 287839 50262 79405311
Completed suicide 730.38 9.44 39 288776 245728 79209845
Drug ineffective 690.61 9.44 6438 282377 1074475 78381098
Aspergillus infection 609.15 9.44 526 288289 18635 79436938
Bronchopulmonary aspergillosis 567.27 9.44 540 288275 21754 79433819
Transplant rejection 552.91 9.44 501 288314 18936 79436637
Pneumocystis jirovecii pneumonia 491.97 9.44 598 288217 31910 79423663
Mucormycosis 491.96 9.44 333 288482 8136 79447437
Posterior reversible encephalopathy syndrome 443.25 9.44 511 288304 25770 79429803
Multiple organ dysfunction syndrome 442.69 9.44 1190 287625 119056 79336517
Blood pressure fluctuation 437.63 9.44 834 287981 66311 79389262
Infusion related reaction 430.63 9.44 1813 287002 228424 79227149
Cytomegalovirus viraemia 421.86 9.44 359 288456 12462 79443111
Kidney transplant rejection 406.68 9.44 320 288495 9926 79445647
Post transplant lymphoproliferative disorder 401.96 9.44 333 288482 11131 79444442
Respiratory failure 360.52 9.44 1453 287362 179458 79276115
Drug abuse 355.99 9.44 77 288738 162614 79292959
Toxicity to various agents 353.97 9.44 615 288200 420925 79034648
Haemophagocytic lymphohistiocytosis 350.58 9.44 414 288401 21423 79434150
Death 350.39 9.44 979 287836 565535 78890038
Polyomavirus-associated nephropathy 335.80 9.44 225 288590 5402 79450171
Strongyloidiasis 333.79 9.44 196 288619 3702 79451871
Epstein-Barr virus infection 332.64 9.44 331 288484 14085 79441488
Cytomegalovirus infection reactivation 324.11 9.44 262 288553 8454 79447119
Thrombotic microangiopathy 323.16 9.44 382 288433 19787 79435786
BK virus infection 305.06 9.44 254 288561 8550 79447023
Fall 303.35 9.44 840 287975 486789 78968784
Nocardiosis 289.28 9.44 206 288609 5473 79450100
Septic shock 287.95 9.44 1039 287776 121762 79333811
Blood pressure diastolic abnormal 275.62 9.44 344 288471 18858 79436715
Klebsiella infection 269.01 9.44 308 288507 15412 79440161
Graft versus host disease in gastrointestinal tract 268.53 9.44 206 288609 6150 79449423
Graft versus host disease 266.64 9.44 300 288515 14726 79440847
Enterococcal infection 264.91 9.44 305 288510 15355 79440218
Complications of transplanted kidney 259.52 9.44 202 288613 6164 79449409
Pneumatosis intestinalis 258.65 9.44 202 288613 6195 79449378
Product dose omission issue 254.74 9.44 313 288502 247224 79208349
Oxygen saturation decreased 253.40 9.44 1032 287783 128015 79327558
Glossodynia 249.54 9.44 38 288777 103299 79352274
Pseudomonas infection 248.04 9.44 341 288474 20562 79435011
Blood pressure systolic abnormal 247.58 9.44 309 288506 16938 79438635
Adenovirus infection 230.98 9.44 213 288602 8234 79447339
Throat irritation 226.43 9.44 475 288340 40471 79415102
Candida infection 222.71 9.44 453 288362 37761 79417812
Progressive multifocal leukoencephalopathy 210.53 9.44 313 288502 20287 79435286
Nausea 209.99 9.44 2338 286477 954858 78500715
Human herpesvirus 6 infection 209.42 9.44 166 288649 5204 79450369
Pneumomediastinum 207.78 9.44 142 288673 3525 79452048
Intentional overdose 205.31 9.44 64 288751 105896 79349677
Urine abnormality 205.11 9.44 197 288618 8022 79447551
Steroid diabetes 203.97 9.44 138 288677 3368 79452205
Blood pressure increased 201.19 9.44 1383 287432 209977 79245596
Cardiac failure congestive 198.71 9.44 136 288679 142266 79313307
Fatigue 195.61 9.44 2292 286523 927435 78528138
Confusional state 194.36 9.44 552 288263 317445 79138128
Dizziness 192.93 9.44 1118 287697 525323 78930250
Synovitis 191.04 9.44 159 288656 150575 79304998
Vomiting 185.35 9.44 1533 287282 664295 78791278
Blood pressure systolic increased 185.21 9.44 599 288216 66387 79389186
Delayed graft function 185.08 9.44 130 288685 3377 79452196
COVID-19 184.21 9.44 1087 287728 156587 79298986
Abdominal discomfort 182.23 9.44 398 288417 250329 79205244
Lymphocyte count decreased 181.99 9.44 476 288339 46813 79408760
Contraindicated product administered 177.46 9.44 185 288630 157353 79298220
Hand deformity 177.34 9.44 77 288738 103842 79351731
Pneumonia cytomegaloviral 175.58 9.44 145 288670 4824 79450749
Graft versus host disease in skin 175.57 9.44 158 288657 5915 79449658
Duodenal ulcer perforation 170.20 9.44 20 288795 66191 79389382
Cystitis haemorrhagic 169.39 9.44 187 288628 8985 79446588
Immunosuppressant drug level increased 168.37 9.44 185 288630 8842 79446731
Overdose 167.20 9.44 255 288560 183951 79271622
Injection site pain 164.48 9.44 137 288678 129701 79325872
Rebound effect 161.35 9.44 163 288652 7063 79448510
Dehydration 160.46 9.44 419 288396 247768 79207805
Lymphopenia 160.31 9.44 347 288468 30210 79425363
Heart rate decreased 158.04 9.44 587 288228 69729 79385844
Acute graft versus host disease in skin 157.00 9.44 165 288650 7493 79448080
Cytomegalovirus test positive 156.89 9.44 147 288668 5800 79449773
Drug intolerance 156.58 9.44 465 288350 263654 79191919
Red blood cells urine positive 155.20 9.44 135 288680 4828 79450745
Alopecia 154.65 9.44 384 288431 230971 79224602
Pericarditis 154.36 9.44 93 288722 104143 79351430
Urine leukocyte esterase positive 154.28 9.44 124 288691 3967 79451606
Rheumatoid factor positive 151.54 9.44 19 288796 59820 79395753
Cytomegalovirus colitis 149.66 9.44 129 288686 4556 79451017
Blood pressure diastolic decreased 149.32 9.44 335 288480 29881 79425692
Acute respiratory distress syndrome 149.02 9.44 423 288392 43644 79411929
Constipation 148.58 9.44 526 288289 282524 79173049
Escherichia infection 148.43 9.44 248 288567 17769 79437804
Varicella zoster virus infection 145.37 9.44 124 288691 4317 79451256
Acinetobacter infection 144.37 9.44 102 288713 2675 79452898
Wound 144.20 9.44 125 288690 116054 79339519
Swelling 143.82 9.44 361 288454 216350 79239223
Irritable bowel syndrome 141.19 9.44 27 288788 62214 79393359
Parvovirus B19 infection 138.92 9.44 79 288736 1401 79454172
Discomfort 138.68 9.44 150 288665 125467 79330106
Myocardial infarction 136.47 9.44 289 288526 183840 79271733
Cushingoid 135.28 9.44 170 288645 9382 79446191
Helicobacter infection 135.20 9.44 42 288773 69662 79385911
Infection reactivation 134.45 9.44 96 288719 2561 79453012
Hospitalisation 134.13 9.44 88 288727 94148 79361425
Diarrhoea 129.98 9.44 2327 286488 878162 78577411
Muscle injury 129.06 9.44 13 288802 48548 79407025
Sleep disorder due to general medical condition, insomnia type 128.98 9.44 7 288808 43549 79412024
Pemphigus 128.70 9.44 103 288712 99479 79356094
Myopathy 128.49 9.44 251 288564 20312 79435261
Liver transplant rejection 127.94 9.44 101 288714 3147 79452426
Disseminated intravascular coagulation 127.04 9.44 350 288465 35492 79420081
Secondary immunodeficiency 126.18 9.44 100 288715 3134 79452439
Wrong technique in product usage process 125.63 9.44 55 288760 73820 79381753
Anti-cyclic citrullinated peptide antibody positive 124.77 9.44 73 288742 83070 79372503
White blood cells urine positive 124.73 9.44 131 288684 5944 79449629
Cytomegalovirus chorioretinitis 124.71 9.44 125 288690 5365 79450208
Disease recurrence 123.33 9.44 396 288419 43713 79411860
Mycobacterium chelonae infection 122.59 9.44 88 288727 2368 79453205
Decreased appetite 119.02 9.44 739 288076 341679 79113894
Drug resistance 118.96 9.44 380 288435 41833 79413740
Arthropathy 118.30 9.44 294 288521 176817 79278756
Suicide attempt 117.28 9.44 78 288737 82854 79372719
Acute graft versus host disease in intestine 114.59 9.44 104 288711 3937 79451636
Pulmonary mucormycosis 114.25 9.44 64 288751 1101 79454472
Hypoglycaemia 113.60 9.44 120 288695 101474 79354099
Enterobacter infection 113.18 9.44 109 288706 4453 79451120
Herpes simplex 112.99 9.44 177 288638 12010 79443563
Leukopenia 111.70 9.44 764 288051 115749 79339824
COVID-19 pneumonia 111.61 9.44 291 288524 28558 79427015
Cerebrovascular accident 110.71 9.44 249 288566 155043 79300530
Osteonecrosis 109.57 9.44 303 288512 30792 79424781
Acute graft versus host disease 108.97 9.44 158 288657 10009 79445564
Nephropathy toxic 107.24 9.44 232 288583 20187 79435386
Adverse event 106.95 9.44 42 288773 60172 79395401
Drug effective for unapproved indication 106.78 9.44 120 288695 5881 79449692
Syncope 106.24 9.44 316 288499 179133 79276440
Serotonin syndrome 105.44 9.44 18 288797 45009 79410564
Chorioretinopathy 104.68 9.44 77 288738 2154 79453419
Pulmonary nocardiosis 102.06 9.44 62 288753 1249 79454324
Systemic lupus erythematosus 101.21 9.44 177 288638 120972 79334601
Rheumatoid arthritis 100.89 9.44 1177 287638 207293 79248280
Systemic candida 100.84 9.44 123 288692 6583 79448990
Chronic allograft nephropathy 98.71 9.44 67 288748 1644 79453929
Disseminated mucormycosis 98.48 9.44 50 288765 698 79454875
Pain 96.84 9.44 1882 286933 701920 78753653
Therapy non-responder 96.78 9.44 619 288196 91686 79363887
Urinary sediment present 95.94 9.44 77 288738 2458 79453115
Peripheral swelling 95.67 9.44 578 288237 269039 79186534
Sepsis 94.98 9.44 1436 287379 267992 79187581
Asthenia 93.54 9.44 1298 287517 510391 78945182
Focal segmental glomerulosclerosis 93.25 9.44 85 288730 3236 79452337
JC virus infection 93.04 9.44 91 288724 3790 79451783
Renal transplant failure 92.15 9.44 67 288748 1840 79453733
Lupus nephritis 90.41 9.44 80 288735 2928 79452645
Rhabdomyolysis 89.52 9.44 147 288668 102984 79352589
Crystal urine present 89.05 9.44 69 288746 2091 79453482
Pneumocystis jirovecii infection 89.04 9.44 78 288737 2816 79452757
Acute graft versus host disease in liver 89.03 9.44 66 288749 1869 79453704
Oedema peripheral 88.90 9.44 542 288273 251746 79203827
Electric shock 88.65 9.44 58 288757 1336 79454237
Injection site erythema 87.83 9.44 92 288723 78105 79377468
Rhinocerebral mucormycosis 87.45 9.44 52 288763 1006 79454567
Infective aneurysm 87.14 9.44 51 288764 957 79454616
Renal tubular atrophy 86.95 9.44 64 288751 1792 79453781
Dyspnoea 86.48 9.44 2404 286411 854621 78600952
Systemic mycosis 86.37 9.44 74 288741 2592 79452981
Viraemia 85.62 9.44 76 288739 2793 79452780
Mycobacterium abscessus infection 85.51 9.44 54 288761 1168 79454405
Diffuse alveolar damage 85.45 9.44 84 288731 3520 79452053
Reversible cerebral vasoconstriction syndrome 85.36 9.44 78 288737 2979 79452594
Transplant failure 84.63 9.44 94 288721 4547 79451026
Folliculitis 83.97 9.44 48 288767 55332 79400241
Knee arthroplasty 83.97 9.44 26 288789 43222 79412351
Staphylococcal sepsis 83.93 9.44 173 288642 14553 79441020
Proteinuria 83.89 9.44 284 288531 32218 79423355
Opportunistic infection 83.80 9.44 76 288739 2874 79452699
Malaise 83.44 9.44 1260 287555 488609 78966964
Loss of personal independence in daily activities 82.87 9.44 153 288662 102427 79353146
Hyperglycaemia 82.13 9.44 485 288330 69850 79385723
Sedation 81.56 9.44 43 288772 51852 79403721
Premature delivery 81.03 9.44 227 288588 23240 79432333
Cytomegalovirus enteritis 80.60 9.44 45 288770 769 79454804
Adverse drug reaction 80.48 9.44 73 288742 66319 79389254
Orthostatic hypotension 79.17 9.44 53 288762 56111 79399462
International normalised ratio increased 79.04 9.44 115 288700 84606 79370967
Aplasia 78.73 9.44 118 288697 7702 79447871
Intensive care unit acquired weakness 78.06 9.44 61 288754 1872 79453701
Bacterial test 78.06 9.44 51 288764 1172 79454401
Polyomavirus viraemia 78.03 9.44 58 288757 1649 79453924
Ear pruritus 77.90 9.44 85 288730 4030 79451543
Pharyngeal paraesthesia 77.10 9.44 70 288745 2651 79452922
Device expulsion 77.06 9.44 4 288811 25857 79429716
Stomatitis 76.74 9.44 273 288542 146484 79309089
Viral haemorrhagic cystitis 76.72 9.44 62 288753 1999 79453574
Cryptococcosis 76.54 9.44 78 288737 3415 79452158
Protein urine present 76.46 9.44 134 288681 9978 79445595
Intentional product misuse 75.93 9.44 143 288672 95022 79360551
Bacterial sepsis 75.91 9.44 119 288696 8079 79447494
Granulomatosis with polyangiitis 75.82 9.44 71 288744 2799 79452774
Blister 75.41 9.44 204 288611 119272 79336301
Staphylococcal infection 75.31 9.44 413 288402 57882 79397691
Ureaplasma infection 74.98 9.44 47 288768 1003 79454570
Accidental exposure to product 74.50 9.44 12 288803 31310 79424263
Thrombocytopenia 74.38 9.44 1362 287453 263897 79191676
Diffuse large B-cell lymphoma 74.33 9.44 147 288668 12002 79443571
Human herpesvirus 8 infection 73.32 9.44 49 288766 1171 79454402
Central nervous system infection 72.56 9.44 51 288764 1326 79454247
Coronary artery disease 72.45 9.44 78 288737 65396 79390177
Contusion 72.42 9.44 285 288530 148491 79307082
Necrotising retinitis 72.41 9.44 49 288766 1196 79454377
Heart rate increased 71.57 9.44 710 288105 120014 79335559
Psoriatic arthropathy 70.70 9.44 108 288707 77891 79377682
Pseudomonal sepsis 70.66 9.44 99 288716 6075 79449498
Glomerulonephritis 70.43 9.44 74 288741 3359 79452214
Urine ketone body present 69.87 9.44 75 288740 3490 79452083
Hyponatraemia 69.13 9.44 370 288445 177478 79278095
Therapeutic product effect decreased 68.17 9.44 333 288482 163530 79292043
Immunosuppressant drug level decreased 67.74 9.44 57 288758 1947 79453626
Vasculitis 67.14 9.44 222 288593 24880 79430693
Large intestine perforation 66.99 9.44 157 288658 14410 79441163
Epstein-Barr virus associated lymphoproliferative disorder 66.94 9.44 73 288742 3459 79452114
Wheezing 66.49 9.44 209 288606 116455 79339118
Accidental overdose 66.45 9.44 30 288785 39551 79416022
Lung abscess 66.06 9.44 78 288737 4034 79451539
General physical health deterioration 65.30 9.44 659 288156 274579 79180994
Pulmonary alveolar haemorrhage 64.60 9.44 134 288681 11323 79444250
Cytomegalovirus enterocolitis 64.19 9.44 51 288764 1604 79453969
Herpes zoster 63.97 9.44 565 288250 92518 79363055
Intervertebral discitis 63.76 9.44 83 288732 4745 79450828
Urine analysis abnormal 63.67 9.44 97 288718 6423 79449150
Bacterial infection 63.60 9.44 253 288562 31027 79424546
Hip arthroplasty 63.40 9.44 25 288790 35731 79419842
Mobility decreased 63.39 9.44 228 288587 121947 79333626
Fibromyalgia 63.36 9.44 84 288731 64256 79391317
Pneumonia cryptococcal 63.20 9.44 49 288766 1486 79454087
Bacteraemia 63.17 9.44 261 288554 32563 79423010
Stenotrophomonas infection 62.99 9.44 73 288742 3700 79451873
Depressed level of consciousness 62.53 9.44 163 288652 96489 79359084
C-reactive protein abnormal 62.51 9.44 50 288765 48317 79407256
Product prescribing error 62.21 9.44 43 288772 44770 79410803
Pathogen resistance 62.10 9.44 151 288664 14191 79441382
Cytomegalovirus oesophagitis 61.90 9.44 37 288778 723 79454850
Atrial fibrillation 61.68 9.44 441 288374 197445 79258128
Fungal infection 61.67 9.44 307 288508 41441 79414132
Graft versus host disease in liver 61.59 9.44 51 288764 1703 79453870
Product quality issue 61.39 9.44 23 288792 33917 79421656
Blood urine present 61.17 9.44 193 288622 21104 79434469
Neutrophil percentage increased 60.98 9.44 80 288735 4609 79450964
Multiple-drug resistance 60.57 9.44 112 288703 8696 79446877
Dural arteriovenous fistula 60.30 9.44 18 288797 47 79455526
Glomerulosclerosis 60.16 9.44 42 288773 1080 79454493
Full blood count abnormal 60.06 9.44 36 288779 40438 79415135
Pleocytosis 59.39 9.44 46 288769 1393 79454180
Neutrophil count increased 59.15 9.44 237 288578 29159 79426414
Swollen joint count increased 58.73 9.44 7 288808 22920 79432653
Symptom masked 58.61 9.44 45 288770 1345 79454228
Encephalitis 58.24 9.44 150 288665 14610 79440963
Chronic graft versus host disease 58.08 9.44 95 288720 6686 79448887
Corynebacterium infection 57.92 9.44 44 288771 1294 79454279
Pneumonia pseudomonal 57.81 9.44 88 288727 5823 79449750
Pyrexia 57.70 9.44 3007 285808 675702 78779871
Demyelination 57.68 9.44 104 288711 7919 79447654
Perinephric abscess 57.64 9.44 25 288790 238 79455335
Injection site bruising 57.38 9.44 39 288776 40963 79414610
Lymphocyte percentage decreased 57.26 9.44 80 288735 4896 79450677
Poisoning 57.23 9.44 11 288804 25261 79430312
Epstein-Barr viraemia 57.20 9.44 54 288761 2151 79453422
Diabetes mellitus 57.09 9.44 482 288333 77908 79377665
Disseminated tuberculosis 56.95 9.44 73 288742 4110 79451463
Kidney fibrosis 56.69 9.44 67 288748 3468 79452105
Blood pressure diastolic increased 56.57 9.44 147 288668 14395 79441178
Device malfunction 56.32 9.44 6 288809 21442 79434131
Brain abscess 56.27 9.44 79 288736 4857 79450716
Penicillium infection 55.71 9.44 25 288790 260 79455313
Mycoplasma infection 55.55 9.44 35 288780 754 79454819
Herpes virus infection 55.37 9.44 95 288720 6954 79448619
Inappropriate schedule of product administration 55.32 9.44 272 288543 133356 79322217
Gastroenteritis norovirus 55.08 9.44 62 288753 3044 79452529
Hypertension 55.03 9.44 1579 287236 329413 79126160
Disseminated strongyloidiasis 54.93 9.44 24 288791 233 79455340
Transient ischaemic attack 54.80 9.44 66 288749 52629 79402944
Injection site swelling 54.57 9.44 54 288761 47078 79408495
Listeriosis 54.39 9.44 53 288762 2197 79453376
Epstein-Barr virus infection reactivation 54.25 9.44 49 288766 1843 79453730
Pneumonia acinetobacter 54.14 9.44 22 288793 175 79455398
Erythema 53.60 9.44 1120 287695 222170 79233403
Culture urine positive 53.59 9.44 73 288742 4362 79451211
Immune thrombocytopenia 53.59 9.44 164 288651 17641 79437932
Fungaemia 53.12 9.44 74 288741 4517 79451056
Hypogammaglobulinaemia 52.53 9.44 133 288682 12818 79442755
Lower respiratory tract infection 52.36 9.44 265 288550 128955 79326618
Ureteric stenosis 52.08 9.44 42 288773 1350 79454223
Unresponsive to stimuli 51.77 9.44 76 288739 55712 79399861
Temperature regulation disorder 51.49 9.44 83 288732 5770 79449803
Renal tubular necrosis 51.29 9.44 203 288612 24836 79430737
Phaeohyphomycosis 51.01 9.44 39 288776 1158 79454415
Neuroleptic malignant syndrome 50.99 9.44 18 288797 27541 79428032
Loss of consciousness 50.53 9.44 378 288437 167565 79288008
Status epilepticus 50.47 9.44 202 288613 24839 79430734
Swollen tongue 50.19 9.44 48 288767 42522 79413051
Cytokine release syndrome 49.87 9.44 260 288555 35738 79419835
Medication error 49.77 9.44 109 288706 68533 79387040
Haemoglobin urine present 49.47 9.44 35 288780 920 79454653
Hypophagia 49.14 9.44 55 288760 45312 79410261
Chest pain 49.05 9.44 723 288092 281581 79173992
Osmotic demyelination syndrome 49.02 9.44 42 288773 1471 79454102
Febrile bone marrow aplasia 49.00 9.44 130 288685 12890 79442683
Osteomyelitis fungal 48.44 9.44 23 288792 275 79455298
Cytomegalovirus hepatitis 48.35 9.44 32 288783 752 79454821
Hypersensitivity 48.24 9.44 664 288151 261575 79193998
Lethargy 48.19 9.44 143 288672 81149 79374424
Respiratory arrest 48.12 9.44 84 288731 57466 79398107
Fusarium infection 47.78 9.44 45 288770 1787 79453786
Disseminated cryptococcosis 47.74 9.44 45 288770 1789 79453784
Tuberculosis 47.63 9.44 142 288673 15056 79440517
Human bocavirus infection 47.38 9.44 31 288784 714 79454859
Rheumatic fever 47.30 9.44 22 288793 28503 79427070
Partial seizures 47.14 9.44 102 288713 8876 79446697
Aplastic anaemia 46.68 9.44 157 288658 17748 79437825
Cerebral aspergillosis 46.62 9.44 44 288771 1752 79453821
Haemolytic uraemic syndrome 46.03 9.44 68 288747 4381 79451192
Malignant neoplasm progression 45.87 9.44 296 288519 135694 79319879
Hallucination 45.82 9.44 158 288657 85587 79369986
Intentional self-injury 45.14 9.44 31 288784 32388 79423185
Gastrointestinal disorder 44.88 9.44 259 288556 121946 79333627
Human polyomavirus infection 44.88 9.44 35 288780 1071 79454502
Red cell distribution width increased 44.58 9.44 139 288676 15103 79440470
Cytomegalovirus gastrointestinal infection 44.51 9.44 26 288789 486 79455087
Central nervous system fungal infection 44.38 9.44 25 288790 435 79455138
Disseminated varicella zoster virus infection 44.37 9.44 28 288787 605 79454968
Immunosuppression 44.35 9.44 124 288691 12679 79442894
Substance-induced psychotic disorder 44.35 9.44 58 288757 3331 79452242
Pneumonia fungal 44.31 9.44 114 288701 11096 79444477
Apoptosis 44.14 9.44 26 288789 494 79455079
Obstructive airways disorder 43.92 9.44 30 288785 31429 79424144
Pulmonary haemorrhage 43.77 9.44 135 288680 14582 79440991
Encephalitis cytomegalovirus 43.67 9.44 35 288780 1115 79454458
Nephrotic syndrome 43.51 9.44 113 288702 11061 79444512
Prostate cancer 43.49 9.44 34 288781 33234 79422339
West Nile viral infection 43.48 9.44 33 288782 969 79454604
B-lymphocyte count decreased 43.28 9.44 38 288777 1376 79454197
Quadriplegia 43.19 9.44 57 288758 3303 79452270
Epstein-Barr virus associated lymphoma 43.19 9.44 34 288781 1055 79454518
Skin striae 42.91 9.44 43 288772 1845 79453728
Escherichia sepsis 42.78 9.44 95 288720 8413 79447160
Amoebic colitis 42.52 9.44 16 288799 101 79455472
Pneumoretroperitoneum 42.38 9.44 18 288797 162 79455411
Pneumothorax 42.34 9.44 209 288606 28114 79427459
Coma 42.15 9.44 204 288611 100445 79355128
Red blood cell sedimentation rate abnormal 41.79 9.44 12 288803 20951 79434622
Adrenal insufficiency 41.73 9.44 209 288606 28278 79427295
Monocyte count increased 41.71 9.44 108 288707 10553 79445020
Polychondritis 41.51 9.44 26 288789 554 79455019
Obliterative bronchiolitis 41.47 9.44 53 288762 2975 79452598
Pneumonia bacterial 41.44 9.44 159 288656 19172 79436401
Shock haemorrhagic 41.38 9.44 163 288652 19897 79435676
Oral herpes 41.34 9.44 203 288612 27251 79428322
Multiple sclerosis 41.17 9.44 175 288640 22107 79433466
Incision site pain 41.09 9.44 51 288764 2779 79452794
Pedal pulse abnormal 41.08 9.44 18 288797 176 79455397
Immunodeficiency 41.03 9.44 172 288643 21596 79433977
Plasma cell myeloma 40.77 9.44 82 288733 53177 79402396
Pseudomonal bacteraemia 40.73 9.44 53 288762 3029 79452544
Muscle spasms 40.32 9.44 421 288394 174309 79281264
Renal graft infection 40.24 9.44 25 288790 525 79455048
Graft loss 40.15 9.44 32 288783 1011 79454562
Scedosporium infection 39.89 9.44 37 288778 1441 79454132
Clostridium difficile colitis 39.88 9.44 226 288589 32057 79423516
Sleep disorder 39.87 9.44 167 288648 85510 79370063
Injection site pruritus 39.82 9.44 57 288758 42226 79413347
Nightmare 39.80 9.44 22 288793 25839 79429734
Segmental diverticular colitis 39.65 9.44 17 288798 157 79455416
Sedation complication 39.61 9.44 5 288810 15664 79439909
Peritonitis 39.19 9.44 203 288612 27833 79427740
Alveolitis 39.15 9.44 61 288754 4119 79451454
Incorrect dose administered 39.08 9.44 144 288671 76486 79379087
Enterococcus test positive 39.03 9.44 43 288772 2061 79453512
Pneumocephalus 39.00 9.44 21 288794 333 79455240
Therapy partial responder 38.87 9.44 145 288670 17252 79438321
Pneumoperitoneum 38.84 9.44 52 288763 3056 79452517
Prescribed overdose 38.80 9.44 48 288767 37835 79417738
Blood calcium decreased 38.54 9.44 35 288780 31784 79423789
Drug interaction 38.32 9.44 1178 287637 414005 79041568
Memory impairment 38.30 9.44 242 288573 111492 79344081
Gastroenteritis rotavirus 38.25 9.44 22 288793 399 79455174
CSF oligoclonal band present 38.25 9.44 22 288793 399 79455174
Pneumonia klebsiella 38.25 9.44 67 288748 4987 79450586
Full blood count decreased 38.21 9.44 25 288790 26794 79428779
Acute kidney injury 38.00 9.44 1517 287298 517887 78937686
Thymus hypoplasia 37.77 9.44 30 288785 943 79454630
Dyskinesia 37.75 9.44 65 288750 44708 79410865
Cardio-respiratory arrest 37.72 9.44 234 288581 108276 79347297
C-reactive protein increased 37.70 9.44 667 288148 128360 79327213
Intra-abdominal pressure increased 37.69 9.44 19 288796 261 79455312
Sleep disorder due to a general medical condition 37.48 9.44 4 288811 14273 79441300
Kaposi's sarcoma 37.44 9.44 27 288788 732 79454841
Feeling abnormal 37.38 9.44 382 288433 158817 79296756
Post-traumatic stress disorder 37.32 9.44 65 288750 4816 79450757
Bacterial test positive 37.26 9.44 83 288732 7366 79448207
Pain in extremity 37.23 9.44 1020 287795 363518 79092055
Blood thyroid stimulating hormone decreased 37.21 9.44 71 288744 5645 79449928
Rash 37.15 9.44 1714 287101 576644 78878929
Respiratory rate increased 37.13 9.44 166 288649 21434 79434139
Intestinal perforation 37.09 9.44 143 288672 17283 79438290
Abdominal infection 36.87 9.44 55 288760 3574 79451999
Multiple sclerosis relapse 36.50 9.44 291 288524 46242 79409331
Cutaneous mucormycosis 36.50 9.44 17 288798 194 79455379
Serum sickness 36.45 9.44 55 288760 3611 79451962
Mycobacterial infection 36.43 9.44 55 288760 3613 79451960
Aggression 36.05 9.44 82 288733 50876 79404697
Hepatic cirrhosis 35.99 9.44 44 288771 34862 79420711
Osteoporosis 35.91 9.44 326 288489 53786 79401787
Leukocytosis 35.88 9.44 275 288540 43180 79412393
Haemodynamic instability 35.66 9.44 141 288674 17241 79438332
Renal impairment 35.45 9.44 784 288031 156999 79298574
Suicidal ideation 35.40 9.44 149 288666 76191 79379382
Pulmonary tuberculosis 35.33 9.44 84 288731 7781 79447792
Cardiac disorder 35.25 9.44 121 288694 65636 79389937
Torsade de pointes 35.07 9.44 13 288802 19299 79436274
Device issue 35.06 9.44 28 288787 27080 79428493
Toxoplasmosis 35.05 9.44 46 288769 2651 79452922
Psoriasis 35.00 9.44 186 288629 89401 79366172
Pancytopenia 34.88 9.44 816 287999 164929 79290644
Lymphoid tissue hypoplasia 34.67 9.44 28 288787 902 79454671
Disseminated varicella zoster vaccine virus infection 34.60 9.44 14 288801 110 79455463
Blood potassium increased 34.52 9.44 33 288782 29242 79426331
Transplant dysfunction 34.49 9.44 79 288736 7142 79448431
Cardiac arrest 34.48 9.44 428 288387 171668 79283905
Candida sepsis 34.44 9.44 44 288771 2469 79453104
Injection site mass 34.35 9.44 15 288800 20169 79435404
Blood cholesterol increased 34.30 9.44 171 288644 83549 79372024
Dermatomyositis 34.11 9.44 53 288762 3570 79452003
Gastrooesophageal reflux disease 34.09 9.44 229 288586 104017 79351556
Oliguria 34.03 9.44 133 288682 16176 79439397
Immune reconstitution inflammatory syndrome 34.02 9.44 119 288696 13722 79441851
Proteus infection 33.73 9.44 40 288775 2078 79453495
Rhinovirus infection 33.65 9.44 83 288732 7870 79447703
Oesophageal candidiasis 33.64 9.44 91 288724 9127 79446446
Urinary tract infection bacterial 33.50 9.44 73 288742 6383 79449190
Treatment noncompliance 33.15 9.44 89 288726 52179 79403394
Underdose 32.92 9.44 43 288772 33108 79422465
Unevaluable event 32.78 9.44 98 288717 55487 79400086
Coeliac disease 32.72 9.44 103 288712 11248 79444325
Parvovirus infection 32.70 9.44 24 288791 669 79454904
Lower limb fracture 32.59 9.44 22 288793 23193 79432380
IgA nephropathy 32.57 9.44 36 288779 1732 79453841
Bone pain 32.36 9.44 99 288716 55643 79399930
Injection site haemorrhage 32.19 9.44 32 288783 27838 79427735
Fungal skin infection 32.17 9.44 69 288746 5967 79449606
Hepatic artery thrombosis 32.17 9.44 18 288797 309 79455264
Enteritis 32.13 9.44 121 288694 14462 79441111
Nitrite urine present 32.11 9.44 30 288785 1179 79454394
Systemic inflammatory response syndrome 32.10 9.44 103 288712 11362 79444211
Steroid withdrawal syndrome 31.85 9.44 24 288791 697 79454876
Meningoencephalitis viral 31.82 9.44 20 288795 429 79455144
Serum ferritin increased 31.81 9.44 93 288722 9754 79445819
Respiratory depression 31.59 9.44 32 288783 27598 79427975
Somnolence 31.52 9.44 643 288172 238338 79217235
Myalgia 31.00 9.44 479 288336 185162 79270411
Device dislocation 30.94 9.44 29 288786 25941 79429632
Necrotising herpetic retinopathy 30.90 9.44 13 288802 114 79455459
Pyelonephritis 30.87 9.44 151 288664 20237 79435336
Abscess bacterial 30.86 9.44 25 288790 809 79454764
Injury 30.78 9.44 160 288655 77336 79378237
Stress 30.71 9.44 166 288649 79446 79376127
Granulocyte count increased 30.56 9.44 30 288785 1255 79454318
Infective pulmonary exacerbation of cystic fibrosis 30.39 9.44 5 288810 12846 79442727
Cryptococcal meningoencephalitis 30.27 9.44 16 288799 244 79455329
Oedema 30.14 9.44 282 288533 119298 79336275
Atypical haemolytic uraemic syndrome 30.13 9.44 27 288788 1005 79454568
Blood immunoglobulin M decreased 30.09 9.44 30 288785 1279 79454294
Device difficult to use 29.94 9.44 6 288809 13379 79442194
Haemolytic anaemia 29.92 9.44 136 288679 17684 79437889
Escherichia urinary tract infection 29.87 9.44 114 288701 13711 79441862
Cerebral venous thrombosis 29.82 9.44 43 288772 2710 79452863
Blood beta-D-glucan increased 29.81 9.44 21 288794 548 79455025
Limbic encephalitis 29.81 9.44 25 288790 850 79454723
Growth retardation 29.80 9.44 36 288779 1907 79453666
Herpes simplex oesophagitis 29.79 9.44 18 288797 359 79455214
Asthma 29.75 9.44 329 288486 134766 79320807
Specific gravity urine decreased 29.73 9.44 25 288790 853 79454720
Lung transplant rejection 29.64 9.44 32 288783 1499 79454074
Hyperkalaemia 29.60 9.44 268 288547 114130 79341443
Reticulocytosis 29.53 9.44 20 288795 489 79455084
Bacillus infection 29.42 9.44 28 288787 1127 79454446
Cerebral fungal infection 29.41 9.44 19 288796 428 79455145
Aplasia pure red cell 29.41 9.44 78 288737 7732 79447841
Calcium ionised decreased 29.22 9.44 21 288794 566 79455007
Anxiety 29.21 9.44 681 288134 247831 79207742
Aphthous ulcer 29.19 9.44 130 288685 16759 79438814
Neurological decompensation 29.10 9.44 61 288754 5192 79450381
Dry skin 28.94 9.44 137 288678 67858 79387715
Laryngeal stenosis 28.90 9.44 27 288788 1061 79454512
Necrosis ischaemic 28.86 9.44 27 288788 1063 79454510
Tremor 28.69 9.44 438 288377 169645 79285928
Injection site reaction 28.56 9.44 102 288713 54683 79400890
Rectal haemorrhage 28.39 9.44 161 288654 76139 79379434
Intestine transplant rejection 28.27 9.44 11 288804 77 79455496
Hepatic enzyme increased 28.22 9.44 478 288337 182132 79273441
Visceral leishmaniasis 28.18 9.44 27 288788 1096 79454477
Angiosarcoma 28.18 9.44 19 288796 461 79455112
Urinary tract candidiasis 28.13 9.44 23 288792 754 79454819
Enterovirus infection 28.13 9.44 35 288780 1912 79453661
Cardiac failure 28.12 9.44 393 288422 154449 79301124
Encephalitis autoimmune 28.08 9.44 38 288777 2256 79453317
Smear cervix abnormal 28.04 9.44 40 288775 2496 79453077
Intentional product use issue 27.87 9.44 735 288080 151377 79304196
Flushing 27.84 9.44 462 288353 87806 79367767
Musculoskeletal pain 27.71 9.44 237 288578 102117 79353456
Monocytopenia 27.71 9.44 13 288802 151 79455422
Product storage error 27.71 9.44 12 288803 16214 79439359
Scopulariopsis infection 27.60 9.44 12 288803 115 79455458
Respiratory distress 27.56 9.44 328 288487 58011 79397562
Amnesia 27.46 9.44 126 288689 62931 79392642
Sputum discoloured 27.45 9.44 23 288792 21720 79433853
Labelled drug-drug interaction medication error 27.32 9.44 36 288779 27614 79427959
Bifidobacterium infection 27.27 9.44 9 288806 36 79455537
Quadriparesis 27.26 9.44 47 288768 3454 79452119
Hepatitis B 27.21 9.44 79 288736 8253 79447320
Lymphocele 27.19 9.44 32 288783 1649 79453924
Gastrointestinal mucormycosis 27.16 9.44 18 288797 424 79455149
Gait disturbance 27.15 9.44 559 288256 206947 79248626
Therapy cessation 26.93 9.44 60 288755 37502 79418071
Viral sepsis 26.84 9.44 13 288802 163 79455410
Hepatic infarction 26.83 9.44 24 288791 891 79454682
Post cholecystectomy syndrome 26.63 9.44 17 288798 375 79455198
Disseminated aspergillosis 26.40 9.44 26 288789 1092 79454481
Venoocclusive disease 26.39 9.44 54 288761 4519 79451054
Malacoplakia gastrointestinal 26.35 9.44 13 288802 170 79455403
Cerebral artery stenosis 26.35 9.44 22 288793 743 79454830
Coronavirus infection 26.35 9.44 73 288742 7424 79448149
Joint swelling 26.35 9.44 820 287995 287826 79167747
Central nervous system lesion 26.27 9.44 107 288708 13261 79442312
Vaccination failure 26.27 9.44 33 288782 1820 79453753
Hypoalbuminaemia 26.25 9.44 149 288666 21148 79434425
Extrapyramidal disorder 26.24 9.44 26 288789 22653 79432920
Device leakage 26.18 9.44 4 288811 10852 79444721
Abdominal pain upper 26.12 9.44 614 288201 223205 79232368
Feeding intolerance 26.10 9.44 23 288792 837 79454736
Neuromyelitis optica spectrum disorder 26.04 9.44 25 288790 1017 79454556
Herpes simplex hepatitis 26.00 9.44 19 288796 526 79455047
Pyelonephritis fungal 25.83 9.44 14 288801 225 79455348
Band sensation 25.79 9.44 22 288793 766 79454807
Body temperature decreased 25.75 9.44 202 288613 31943 79423630
Product dispensing error 25.70 9.44 8 288807 13255 79442318
Human ehrlichiosis 25.63 9.44 19 288796 538 79455035
Red blood cells urine 25.60 9.44 21 288794 692 79454881
American trypanosomiasis 25.59 9.44 16 288799 340 79455233
Nodular regenerative hyperplasia 25.57 9.44 28 288787 1333 79454240
Finger deformity 25.51 9.44 72 288743 7402 79448171
Pregnancy 25.48 9.44 36 288779 26815 79428758
Neuropsychiatric lupus 25.45 9.44 13 288802 184 79455389
Lip dry 25.39 9.44 12 288803 15406 79440167
Palmar-plantar erythrodysaesthesia syndrome 25.37 9.44 51 288764 33083 79422490
Drug withdrawal syndrome 25.27 9.44 55 288760 34663 79420910
Breast cancer stage III 25.17 9.44 3 288812 9823 79445750
Central nervous system lymphoma 25.16 9.44 36 288779 2253 79453320
Mycotic endophthalmitis 25.14 9.44 13 288802 189 79455384
Staphylococcal mediastinitis 25.03 9.44 9 288806 49 79455524
Exostosis 25.00 9.44 15 288800 16843 79438730
Klebsiella test positive 24.93 9.44 31 288784 1692 79453881
Incorrect route of product administration 24.88 9.44 56 288759 34873 79420700
Heart transplant rejection 24.85 9.44 29 288786 1481 79454092
Drug tolerance decreased 24.84 9.44 8 288807 12970 79442603
Antineutrophil cytoplasmic antibody positive 24.76 9.44 27 288788 1279 79454294
Haemoglobin urine 24.73 9.44 12 288803 151 79455422
Oesophageal carcinoma 24.73 9.44 5 288810 11079 79444494
Aspergillosis oral 24.73 9.44 9 288806 51 79455522
Delirium 24.72 9.44 192 288623 84435 79371138
Abscess 24.71 9.44 155 288660 22796 79432777
Graft complication 24.69 9.44 21 288794 728 79454845
Impaired healing 24.62 9.44 201 288614 87454 79368119
Hepatic failure 24.60 9.44 334 288481 60878 79394695
Splenic embolism 24.55 9.44 13 288802 199 79455374
Complications of transplant surgery 24.50 9.44 21 288794 736 79454837
Central nervous system viral infection 24.46 9.44 11 288804 115 79455458
Factor XIII deficiency 24.46 9.44 10 288805 81 79455492
Morganella infection 24.39 9.44 25 288790 1102 79454471
Neutrophil count decreased 24.36 9.44 220 288595 93739 79361834
Acute myocardial infarction 24.31 9.44 171 288644 76865 79378708
Serratia infection 24.19 9.44 31 288784 1745 79453828
Epstein-Barr virus test positive 24.17 9.44 25 288790 1114 79454459
Osteoarthritis 24.16 9.44 201 288614 87108 79368465
Pain in jaw 24.01 9.44 86 288729 46065 79409508
Food allergy 24.00 9.44 90 288725 10734 79444839
Akathisia 23.95 9.44 9 288806 13250 79442323
Restlessness 23.95 9.44 87 288728 46405 79409168
Electrocardiogram QRS complex prolonged 23.94 9.44 5 288810 10828 79444745
Toxic epidermal necrolysis 23.93 9.44 257 288558 44324 79411249
Abnormal dreams 23.75 9.44 6 288809 11406 79444167
Sideroblastic anaemia 23.72 9.44 14 288801 267 79455306
Abdominal abscess 23.68 9.44 68 288747 7059 79448514
Trichodysplasia spinulosa 23.68 9.44 21 288794 771 79454802
Cystitis bacterial 23.60 9.44 20 288795 690 79454883
Graft infection 23.57 9.44 20 288795 691 79454882
Rubella antibody positive 23.51 9.44 9 288806 60 79455513
Blood immunoglobulin A increased 23.47 9.44 23 288792 960 79454613
Capillaritis 23.45 9.44 14 288801 273 79455300
Facet joint syndrome 23.41 9.44 6 288809 11296 79444277
Endocarditis 23.41 9.44 88 288727 10509 79445064
Malacoplakia 23.40 9.44 19 288796 617 79454956
Staphylococcal bacteraemia 23.39 9.44 97 288718 12121 79443452
Therapeutic response decreased 23.38 9.44 356 288459 66497 79389076
Herpes simplex colitis 23.31 9.44 8 288807 37 79455536
Electrocardiogram QT prolonged 23.27 9.44 212 288603 90174 79365399
Hepatosplenomegaly 23.25 9.44 61 288754 6008 79449565
Klebsiella sepsis 23.18 9.44 42 288773 3210 79452363
Lymphoproliferative disorder 23.13 9.44 58 288757 5557 79450016
Viral infection 23.10 9.44 248 288567 42768 79412805
Agitation 23.10 9.44 240 288575 99475 79356098
Angiocentric lymphoma 23.08 9.44 22 288793 887 79454686
Atypical mycobacterial infection 23.07 9.44 30 288785 1713 79453860
Renal vein thrombosis 23.02 9.44 18 288797 553 79455020
Blood parathyroid hormone decreased 23.00 9.44 5 288810 10531 79445042
Tuberculosis gastrointestinal 22.93 9.44 18 288797 556 79455017
Creatinine renal clearance decreased 22.90 9.44 21 288794 18981 79436592
Osteonecrosis of jaw 22.85 9.44 80 288735 43146 79412427
Lung neoplasm malignant 22.84 9.44 41 288774 27751 79427822
Pulmonary hypertension 22.81 9.44 93 288722 47987 79407586
Lip swelling 22.80 9.44 74 288741 40837 79414736
Kidney rupture 22.79 9.44 13 288802 232 79455341
Steroid dependence 22.74 9.44 37 288778 2593 79452980
Mitochondrial DNA mutation 22.73 9.44 16 288799 417 79455156
Adjustment disorder with depressed mood 22.72 9.44 3 288812 9083 79446490
Pruritus 22.67 9.44 1183 287632 393465 79062108
Joint injury 22.51 9.44 50 288765 31285 79424288
Enthesopathy 22.49 9.44 7 288808 11601 79443972
Blood brain barrier defect 22.49 9.44 11 288804 141 79455432
Bone erosion 22.38 9.44 19 288796 17828 79437745
B-cell lymphoma 22.33 9.44 61 288754 6154 79449419
Urobilinogen urine increased 22.21 9.44 19 288796 664 79454909
Angina pectoris 22.15 9.44 104 288711 51628 79403945
Adenoviral haemorrhagic cystitis 22.14 9.44 17 288798 508 79455065
Autoimmune thyroiditis 22.12 9.44 48 288767 4185 79451388
Bacterial vulvovaginitis 22.10 9.44 18 288797 587 79454986
Rheumatoid factor increased 22.04 9.44 30 288785 1791 79453782
Malacoplakia vesicae 22.00 9.44 9 288806 73 79455500
Pancreas transplant rejection 21.84 9.44 14 288801 311 79455262
Haematemesis 21.84 9.44 106 288709 52158 79403415
Multi-organ disorder 21.82 9.44 36 288779 2552 79453021
Optic neuritis 21.82 9.44 80 288735 9440 79446133
Leishmaniasis 21.72 9.44 15 288800 379 79455194
Parainfluenzae virus infection 21.65 9.44 57 288758 5625 79449948
Papilloma viral infection 21.65 9.44 29 288786 1705 79453868
Acute respiratory failure 21.57 9.44 319 288496 59222 79396351
Dengue fever 21.56 9.44 21 288794 870 79454703
Blindness cortical 21.55 9.44 22 288793 965 79454608
Herpes oesophagitis 21.54 9.44 15 288800 384 79455189
Dementia 21.53 9.44 35 288780 24624 79430949
Insomnia 21.53 9.44 700 288115 244470 79211103
Microangiopathy 21.49 9.44 30 288785 1835 79453738
Complication associated with device 21.48 9.44 19 288796 17477 79438096
Cutaneous malacoplakia 21.48 9.44 10 288805 114 79455459
Pulmonary arterial hypertension 21.43 9.44 44 288771 28322 79427251
Poikiloderma 21.41 9.44 15 288800 388 79455185
Venoocclusive liver disease 21.40 9.44 92 288723 11679 79443894
Blastomycosis 21.37 9.44 19 288796 700 79454873
Autoimmune hepatitis 21.35 9.44 92 288723 11691 79443882
Thunderclap headache 21.34 9.44 15 288800 390 79455183
Thrombosis 21.33 9.44 198 288617 83902 79371671
Atypical mycobacterial pneumonia 21.33 9.44 11 288804 159 79455414
Flatulence 21.32 9.44 81 288734 42643 79412930
Haemoperitoneum 21.28 9.44 48 288767 4295 79451278
Head injury 21.24 9.44 67 288748 37302 79418271
Eosinopenia 21.20 9.44 8 288807 51 79455522
Impaired work ability 21.16 9.44 24 288791 19657 79435916
Product use issue 21.16 9.44 588 288227 209234 79246339
Lip pruritus 21.15 9.44 21 288794 891 79454682
Respiratory tract infection fungal 21.15 9.44 24 288791 1189 79454384
Dysgeusia 21.08 9.44 121 288694 57056 79398517
Dystonia 21.00 9.44 28 288787 21371 79434202
Mental status changes 20.95 9.44 149 288666 66810 79388763
Lymphocytosis 20.95 9.44 50 288765 4643 79450930
Pneumonia necrotising 20.92 9.44 24 288791 1203 79454370
Blindness 20.91 9.44 175 288640 28208 79427365
Right ventricular failure 20.84 9.44 33 288782 23464 79432109
Granuloma skin 20.76 9.44 4 288811 9170 79446403
Condition aggravated 20.71 9.44 2095 286720 499029 78956544
Norovirus test positive 20.68 9.44 18 288797 644 79454929
Anti-thyroid antibody positive 20.64 9.44 16 288799 485 79455088
Intracranial infection 20.63 9.44 9 288806 87 79455486
Diaphragmatic injury 20.60 9.44 10 288805 126 79455447
Aspartate aminotransferase 20.57 9.44 17 288798 566 79455007
Oral pruritus 20.57 9.44 34 288781 2414 79453159
Bradycardia 20.56 9.44 356 288459 135201 79320372
Ultrasound ovary abnormal 20.54 9.44 9 288806 88 79455485
Sinusitis 20.46 9.44 545 288270 194956 79260617
CSF measles antibody positive 20.44 9.44 8 288807 57 79455516
Herpes zoster meningoencephalitis 20.44 9.44 19 288796 742 79454831
Post procedural bile leak 20.41 9.44 15 288800 419 79455154
Fear 20.35 9.44 30 288785 21956 79433617
Inflammatory marker increased 20.35 9.44 85 288730 10655 79444918
Cytopenia 20.32 9.44 135 288680 20248 79435325
Organising pneumonia 20.28 9.44 86 288729 10853 79444720
Oral pain 20.27 9.44 54 288761 31744 79423829
Vesicoureteric reflux 20.19 9.44 10 288805 132 79455441
Reticulocytopenia 20.14 9.44 12 288803 233 79455340
Microsporidia infection 20.13 9.44 21 288794 945 79454628
Listeria encephalitis 20.00 9.44 13 288802 296 79455277
Mouth ulceration 19.99 9.44 220 288595 38174 79417399
Gastropleural fistula 19.98 9.44 8 288807 61 79455512
Urine oxalate increased 19.96 9.44 12 288803 237 79455336
Herpes simplex viraemia 19.89 9.44 15 288800 436 79455137
Irritability 19.89 9.44 79 288736 41065 79414508
Intestinal ischaemia 19.89 9.44 98 288717 13172 79442401
Toxic neuropathy 19.88 9.44 21 288794 959 79454614
Tubulointerstitial nephritis 19.87 9.44 219 288596 38016 79417557
Hypocalcaemia 19.86 9.44 103 288712 49821 79405752
Natural killer-cell leukaemia 19.86 9.44 9 288806 96 79455477
Central nervous system vasculitis 19.84 9.44 25 288790 1383 79454190
Poor venous access 19.81 9.44 123 288692 18026 79437547
Varicella 19.81 9.44 37 288778 2895 79452678
Central obesity 19.80 9.44 28 288787 1733 79453840
Meningitis fungal 19.75 9.44 11 288804 187 79455386
Angiosarcoma metastatic 19.73 9.44 10 288805 139 79455434
Marrow hyperplasia 19.72 9.44 27 288788 1621 79453952
Monocyte percentage increased 19.71 9.44 31 288784 2110 79453463
Haemorrhagic varicella syndrome 19.68 9.44 5 288810 5 79455568
Tumefactive multiple sclerosis 19.61 9.44 9 288806 99 79455474
Urine leukocyte esterase 19.60 9.44 11 288804 190 79455383
Headache 19.59 9.44 2071 286744 651701 78803872
Birdshot chorioretinopathy 19.54 9.44 8 288807 65 79455508
Pyomyositis 19.54 9.44 17 288798 608 79454965
Encephalopathy 19.53 9.44 348 288467 67049 79388524
Cytomegalovirus gastritis 19.49 9.44 15 288800 450 79455123
Aspergilloma 19.47 9.44 17 288798 611 79454962
Necrosis 19.47 9.44 77 288738 9416 79446157
Hypokalaemia 19.44 9.44 386 288429 143654 79311919
Post procedural urine leak 19.42 9.44 10 288805 144 79455429
Subcutaneous emphysema 19.40 9.44 28 288787 1766 79453807
Bone marrow failure 19.38 9.44 276 288539 50831 79404742
Blood immunoglobulin G decreased 19.37 9.44 40 288775 3369 79452204
Leukoencephalopathy 19.34 9.44 68 288747 7861 79447712
Night sweats 19.34 9.44 110 288705 51985 79403588
Arterial rupture 19.31 9.44 19 288796 797 79454776
Salivary hypersecretion 19.28 9.44 14 288801 14210 79441363
Biloma 19.24 9.44 10 288805 147 79455426
Tularaemia 19.23 9.44 9 288806 104 79455469
Urinary retention 19.22 9.44 123 288692 56507 79399066
Coma scale abnormal 19.19 9.44 4 288811 8674 79446899
Myoclonus 19.17 9.44 45 288770 27615 79427958
Road traffic accident 19.16 9.44 87 288728 43577 79411996
Bordetella infection 19.15 9.44 9 288806 105 79455468
Cytomegalovirus nephritis 19.12 9.44 10 288805 149 79455424
Muscle twitching 19.06 9.44 38 288777 24726 79430847
CSF protein increased 19.06 9.44 23 288792 1217 79454356
Blood creatinine decreased 18.99 9.44 67 288748 7758 79447815
Q fever 18.94 9.44 12 288803 261 79455312
Bronchiolitis obliterans syndrome 18.91 9.44 13 288802 326 79455247
Injection site induration 18.89 9.44 6 288809 9813 79445760
Metastases to liver 18.88 9.44 47 288768 28267 79427306
Needle issue 18.87 9.44 12 288803 13056 79442517
Arteriosclerosis coronary artery 18.86 9.44 22 288793 17794 79437779
Gastroenteritis Escherichia coli 18.85 9.44 17 288798 638 79454935
Tendonitis 18.83 9.44 36 288779 23794 79431779
Blood loss anaemia 18.83 9.44 17 288798 15481 79440092
Microscopic polyangiitis 18.81 9.44 14 288801 399 79455174
Depression 18.78 9.44 620 288195 216170 79239403
Joint tuberculosis 18.77 9.44 10 288805 155 79455418
Menstruation irregular 18.66 9.44 50 288765 4986 79450587
Hilar lymphadenopathy 18.64 9.44 28 288787 1831 79453742
Pyelonephritis acute 18.61 9.44 56 288759 5967 79449606
Erosive duodenitis 18.60 9.44 30 288785 2087 79453486
Chronic graft versus host disease in liver 18.59 9.44 17 288798 650 79454923
Passenger lymphocyte syndrome 18.57 9.44 9 288806 113 79455460
Temperature intolerance 18.54 9.44 77 288738 9628 79445945
Renal haemorrhage 18.51 9.44 31 288784 2225 79453348
Product label confusion 18.50 9.44 26 288789 1600 79453973
Paranoia 18.49 9.44 26 288789 19406 79436167
Liver abscess 18.44 9.44 56 288759 5998 79449575
Blood lactate dehydrogenase increased 18.40 9.44 220 288595 38950 79416623
Amoebiasis 18.36 9.44 9 288806 116 79455457
Bronchopleural fistula 18.33 9.44 17 288798 662 79454911
Blood urea increased 18.31 9.44 263 288552 48527 79407046
Superinfection bacterial 18.29 9.44 25 288790 1499 79454074
Injection site warmth 18.28 9.44 16 288799 14791 79440782
Disability 18.27 9.44 21 288794 17099 79438474
Glomerulonephritis rapidly progressive 18.23 9.44 26 288789 1622 79453951
Subcapsular renal haematoma 18.22 9.44 18 288797 759 79454814
Nosocomial infection 18.22 9.44 35 288780 2797 79452776
Delayed engraftment 18.21 9.44 12 288803 280 79455293
Hypersomnia 18.14 9.44 35 288780 23051 79432522
Skin irritation 18.13 9.44 9 288806 11231 79444342
Meningomyelitis herpes 18.10 9.44 8 288807 80 79455493
Scleroderma renal crisis 18.09 9.44 16 288799 585 79454988
Cataract 18.09 9.44 321 288494 61799 79393774
Suspected COVID-19 18.08 9.44 37 288778 3096 79452477
Fracture 18.06 9.44 32 288783 21769 79433804
Dyspnoea exertional 18.02 9.44 215 288600 86858 79368715
Hepatic necrosis 18.01 9.44 73 288742 9027 79446546
Demodicidosis 18.00 9.44 11 288804 224 79455349
Muir-Torre syndrome 17.99 9.44 7 288808 49 79455524
Infectious pleural effusion 17.93 9.44 41 288774 3703 79451870
Type 2 diabetes mellitus 17.92 9.44 127 288688 56995 79398578
Bronchopneumopathy 17.91 9.44 18 288797 775 79454798
Lichen sclerosus 17.90 9.44 20 288795 974 79454599
Red blood cell count increased 17.89 9.44 44 288771 4164 79451409
Moyamoya disease 17.85 9.44 8 288807 83 79455490
Dehiscence 17.80 9.44 10 288805 173 79455400
Fungal endocarditis 17.80 9.44 16 288799 598 79454975
Immune effector cell-associated neurotoxicity syndrome 17.72 9.44 54 288761 5794 79449779
Jejunal perforation 17.69 9.44 13 288802 363 79455210
Atrial flutter 17.68 9.44 32 288783 21593 79433980
Wound infection bacterial 17.67 9.44 19 288796 886 79454687
Butterfly rash 17.66 9.44 26 288789 1670 79453903
Hepatic cancer 17.64 9.44 8 288807 10521 79445052
Histoplasmosis disseminated 17.55 9.44 31 288784 2322 79453251
Pericarditis fungal 17.55 9.44 10 288805 178 79455395
Cytomegalovirus duodenitis 17.52 9.44 8 288807 87 79455486
Swelling face 17.49 9.44 169 288646 71043 79384530
Meningitis cryptococcal 17.46 9.44 39 288776 3467 79452106
Arteriovenous fistula 17.45 9.44 23 288792 1331 79454242
Acute disseminated encephalomyelitis 17.45 9.44 12 288803 301 79455272
Device related sepsis 17.42 9.44 56 288759 6184 79449389
Encephalitis brain stem 17.34 9.44 11 288804 240 79455333
Atrioventricular block first degree 17.32 9.44 12 288803 12479 79443094
Specific gravity urine increased 17.31 9.44 14 288801 452 79455121
Leukocyturia 17.28 9.44 28 288787 1955 79453618
Breast cancer female 17.28 9.44 10 288805 11451 79444122
Trichophytosis 17.27 9.44 13 288802 377 79455196
Cervicitis 17.26 9.44 11 288804 242 79455331
Peliosis hepatis 17.22 9.44 9 288806 134 79455439
Brain oedema 17.17 9.44 153 288662 25110 79430463
Herpes simplex encephalitis 17.16 9.44 17 288798 719 79454854
Cerebellar stroke 17.07 9.44 15 288800 544 79455029
Heliotrope rash 16.88 9.44 10 288805 192 79455381
Cryptococcal cutaneous infection 16.88 9.44 10 288805 192 79455381
Hypoproteinaemia 16.88 9.44 42 288773 4004 79451569
Cerebral venous sinus thrombosis 16.86 9.44 30 288785 2261 79453312
Jaundice cholestatic 16.79 9.44 10 288805 11274 79444299
Microangiopathic haemolytic anaemia 16.76 9.44 24 288791 1503 79454070
B-lymphocyte count increased 16.75 9.44 9 288806 142 79455431
Diffuse large B-cell lymphoma stage III 16.75 9.44 8 288807 97 79455476
Rash pruritic 16.75 9.44 172 288643 71457 79384116
Transaminases increased 16.75 9.44 272 288543 51471 79404102
Engraftment syndrome 16.73 9.44 23 288792 1386 79454187
Meningitis bacterial 16.65 9.44 33 288782 2699 79452874
Abdominal distension 16.64 9.44 319 288496 119331 79336242
Escherichia bacteraemia 16.63 9.44 57 288758 6505 79449068
Blood sodium decreased 16.62 9.44 63 288752 33192 79422381
Drug level decreased 16.60 9.44 99 288716 14303 79441270
Arrhythmia 16.53 9.44 142 288673 61130 79394443
Listeria sepsis 16.48 9.44 17 288798 755 79454818
Coccidioidomycosis 16.47 9.44 22 288793 1290 79454283
Peripheral venous disease 16.46 9.44 20 288795 15889 79439684
Surgery 16.43 9.44 62 288753 32704 79422869
Hypertensive encephalopathy 16.39 9.44 19 288796 963 79454610
Red blood cell schistocytes present 16.39 9.44 15 288800 574 79454999
Anaemia 16.39 9.44 1388 287427 443627 79011946
Aspergillus test positive 16.37 9.44 17 288798 761 79454812
Central nervous system lupus 16.37 9.44 14 288801 489 79455084
Cutaneous nocardiosis 16.35 9.44 10 288805 204 79455369
Electrocardiogram abnormal 16.32 9.44 22 288793 16715 79438858
Sexual dysfunction 16.32 9.44 4 288811 7759 79447814
Perineal ulceration 16.29 9.44 7 288808 65 79455508
Glomerular filtration rate increased 16.28 9.44 21 288794 1190 79454383
Uraemic encephalopathy 16.27 9.44 16 288799 671 79454902
Haematopoietic stem cell mobilisation 16.26 9.44 10 288805 206 79455367
Hepatitis 16.24 9.44 288 288527 55439 79400134
Erythema infectiosum 16.22 9.44 10 288805 207 79455366
Myocarditis infectious 16.20 9.44 7 288808 66 79455507
Interleukin level increased 16.20 9.44 15 288800 583 79454990
Band neutrophil percentage increased 16.17 9.44 13 288802 416 79455157
Dermatitis acneiform 16.12 9.44 8 288807 9985 79445588
Herpes simplex meningoencephalitis 16.11 9.44 7 288808 67 79455506
Myasthenia gravis crisis 16.09 9.44 20 288795 1091 79454482
Polyglandular disorder 16.06 9.44 6 288809 37 79455536
Arterial spasm 16.06 9.44 9 288806 155 79455418
Prescribed underdose 16.02 9.44 54 288761 29460 79426113
Gonococcal infection 16.02 9.44 7 288808 68 79455505
Thyroxine free increased 15.99 9.44 21 288794 1211 79454362
Osteogenesis imperfecta 15.95 9.44 14 288801 507 79455066
Coronary artery dilatation 15.93 9.44 6 288809 38 79455535
Torulopsis infection 15.93 9.44 6 288809 38 79455535
Therapy interrupted 15.91 9.44 59 288756 31282 79424291
Hemianopia 15.88 9.44 25 288790 1703 79453870
Intestinal obstruction 15.88 9.44 91 288724 42929 79412644
Anti-neutrophil cytoplasmic antibody positive vasculitis 15.87 9.44 39 288776 3690 79451883
Exophthalmos 15.86 9.44 25 288790 1705 79453868
Feeling hot 15.77 9.44 304 288511 59430 79396143
Pneumonia lipoid 15.76 9.44 9 288806 161 79455412
Hypertransaminasaemia 15.75 9.44 85 288730 11839 79443734
Meningitis exserohilum 15.74 9.44 4 288811 4 79455569
Chimerism 15.68 9.44 11 288804 285 79455288
Glomerulonephritis membranoproliferative 15.67 9.44 15 288800 608 79454965
Viral cardiomyopathy 15.67 9.44 6 288809 40 79455533
Orbital apex syndrome 15.67 9.44 7 288808 72 79455501
Product substitution issue 15.66 9.44 31 288784 20225 79435348
Drug eruption 15.65 9.44 94 288721 43841 79411732
Cryptitis 15.62 9.44 11 288804 287 79455286
Encephalomyelitis 15.57 9.44 10 288805 223 79455350
Transient hypogammaglobulinaemia of infancy 15.55 9.44 6 288809 41 79455532
Product administration error 15.49 9.44 61 288754 31785 79423788
Fear of injection 15.42 9.44 4 288811 7470 79448103
Empyema 15.39 9.44 42 288773 4234 79451339
Acarodermatitis 15.38 9.44 22 288793 1376 79454197
Nephropathy 15.38 9.44 73 288742 9665 79445908
Tri-iodothyronine free decreased 15.36 9.44 12 288803 368 79455205
Peritoneal candidiasis 15.35 9.44 5 288810 19 79455554
Parathyroid hyperplasia 15.32 9.44 9 288806 170 79455403
Meningoencephalitis bacterial 15.30 9.44 10 288805 230 79455343
Episcleritis 15.30 9.44 19 288796 1036 79454537
Pyometra 15.26 9.44 7 288808 77 79455496
Malignant catatonia 15.25 9.44 13 288802 452 79455121
Metabolic encephalopathy 15.25 9.44 7 288808 9140 79446433
Eye infection toxoplasmal 15.25 9.44 14 288801 538 79455035
Ophthalmoplegia 15.19 9.44 33 288782 2879 79452694
Miosis 15.15 9.44 21 288794 15768 79439805
Double stranded DNA antibody positive 15.11 9.44 13 288802 458 79455115
Vasculitis necrotising 15.11 9.44 21 288794 1279 79454294
Thyroid gland abscess 15.10 9.44 7 288808 79 79455494
Radiotherapy to brain 15.07 9.44 6 288809 45 79455528
Seroconversion test positive 15.07 9.44 6 288809 45 79455528
Throat tightness 15.04 9.44 161 288654 27746 79427827
Gastroenteritis salmonella 15.03 9.44 19 288796 1055 79454518
Bladder cancer 15.00 9.44 30 288785 19496 79436077
Breast cancer stage I 15.00 9.44 3 288812 6697 79448876
Dermatophytosis 14.97 9.44 13 288802 464 79455109
Sopor 14.95 9.44 65 288750 32945 79422628
Premenstrual syndrome 14.95 9.44 14 288801 552 79455021
Pleural mass 14.94 9.44 7 288808 81 79455492
Ovarian fibroma 14.94 9.44 7 288808 81 79455492
Rheumatoid factor 14.93 9.44 12 288803 384 79455189
Herpes simplex reactivation 14.92 9.44 13 288802 466 79455107
Creatinine urine increased 14.89 9.44 14 288801 555 79455018
Eschar 14.88 9.44 21 288794 1297 79454276
Acute allograft nephropathy 14.85 9.44 6 288809 47 79455526
Crying 14.79 9.44 39 288776 23004 79432569
Encephalitis fungal 14.78 9.44 9 288806 182 79455391
Intra-abdominal haemorrhage 14.78 9.44 43 288772 4497 79451076
Nephritis 14.78 9.44 41 288774 4173 79451400
Haemostasis 14.77 9.44 12 288803 390 79455183
Skin haemorrhage 14.73 9.44 13 288802 11968 79443605
Myelitis 14.71 9.44 29 288786 2362 79453211
Granulomatous liver disease 14.70 9.44 21 288794 1312 79454261
Arthritis bacterial 14.68 9.44 69 288746 9097 79446476
Chemotherapeutic drug level above therapeutic 14.65 9.44 7 288808 85 79455488
Propofol infusion syndrome 14.63 9.44 26 288789 1957 79453616
Aortitis salmonella 14.59 9.44 5 288810 23 79455550
Erectile dysfunction 14.58 9.44 19 288796 14645 79440928
Disseminated blastomycosis 14.57 9.44 9 288806 187 79455386
Multiple allergies 14.57 9.44 10 288805 10450 79445123
Seizure 14.53 9.44 548 288267 188286 79267287
Sinus polyp degeneration 14.53 9.44 6 288809 50 79455523
Arthritis fungal 14.52 9.44 8 288807 133 79455440
Porokeratosis 14.50 9.44 10 288805 252 79455321
Acinetobacter test positive 14.47 9.44 10 288805 253 79455320
Thyroid stimulating immunoglobulin increased 14.43 9.44 7 288808 88 79455485
Lupus myocarditis 14.43 9.44 7 288808 88 79455485
Renal hypertrophy 14.42 9.44 6 288809 51 79455522
Skin lesion inflammation 14.42 9.44 6 288809 51 79455522
Alveolar proteinosis 14.42 9.44 16 288799 773 79454800
Hepatitis C 14.41 9.44 83 288732 11842 79443731
Secretion discharge 14.39 9.44 20 288795 15002 79440571
Band neutrophil count increased 14.38 9.44 15 288800 675 79454898
Renal artery stenosis 14.37 9.44 36 288779 3446 79452127
Nocturia 14.37 9.44 17 288798 13664 79441909
Complications of transplanted liver 14.36 9.44 12 288803 406 79455167
Activated partial thromboplastin time shortened 14.35 9.44 17 288798 882 79454691
Accident 14.35 9.44 7 288808 8824 79446749
Glomerulonephritis membranous 14.33 9.44 23 288792 1593 79453980
Injection site rash 14.30 9.44 27 288788 17927 79437646
Neoplasm progression 14.29 9.44 119 288696 51563 79404010
Rhodococcus infection 14.26 9.44 11 288804 331 79455242
Community acquired infection 14.25 9.44 5 288810 25 79455548
Blood glucose decreased 14.24 9.44 48 288767 26186 79429387
Respiratory disorder 14.22 9.44 235 288580 44621 79410952
Hospice care 14.20 9.44 10 288805 10314 79445259
Respiratory tract congestion 14.20 9.44 32 288783 19922 79435651
Blood pressure decreased 14.20 9.44 264 288551 99202 79356371
Macular degeneration 14.20 9.44 12 288803 11284 79444289
White blood cell count decreased 14.14 9.44 548 288267 187740 79267833
Arteritis coronary 14.13 9.44 6 288809 54 79455519
Bacteroides infection 14.12 9.44 11 288804 336 79455237
Amoebic dysentery 14.09 9.44 5 288810 26 79455547
Japanese spotted fever 14.09 9.44 5 288810 26 79455547
Meningitis aseptic 14.05 9.44 56 288759 6872 79448701
Haemorrhoids 14.03 9.44 56 288759 29072 79426501
Venous thrombosis 14.02 9.44 57 288758 7059 79448514
Emphysematous pyelonephritis 14.01 9.44 11 288804 340 79455233
Cestode infection 13.97 9.44 10 288805 268 79455305
Thirst 13.97 9.44 29 288786 18590 79436983
Gastrointestinal candidiasis 13.96 9.44 12 288803 422 79455151
Diabetic macroangiopathy 13.96 9.44 8 288807 144 79455429
Hepatitis cholestatic 13.96 9.44 92 288723 13760 79441813
Infected varicose vein 13.94 9.44 5 288810 27 79455546
Adenoviral hepatitis 13.93 9.44 17 288798 910 79454663
Drug tolerance 13.91 9.44 7 288808 8668 79446905
Reticuloendothelial dysfunction 13.87 9.44 3 288812 0 79455573
Cytokine storm 13.84 9.44 18 288797 1028 79454545
Pyuria 13.84 9.44 28 288787 2324 79453249
Onychomycosis 13.83 9.44 63 288752 8198 79447375
Heart rate irregular 13.83 9.44 180 288635 32499 79423074
Personality change 13.80 9.44 10 288805 10160 79445413
Cholelithiasis 13.78 9.44 123 288692 52541 79403032
Ureteral necrosis 13.77 9.44 7 288808 98 79455475
Transfusion 13.77 9.44 36 288779 21294 79434279
Abscess fungal 13.76 9.44 11 288804 349 79455224
Bradyphrenia 13.75 9.44 11 288804 10629 79444944
Drug-induced liver injury 13.74 9.44 325 288490 65792 79389781
Cystitis viral 13.72 9.44 15 288800 713 79454860
Mycobacterium kansasii infection 13.71 9.44 11 288804 351 79455222
Pelvic venous thrombosis 13.71 9.44 27 288788 2198 79453375
Viral vasculitis 13.67 9.44 8 288807 150 79455423
Urine bilirubin decreased 13.67 9.44 8 288807 150 79455423
Retinal detachment 13.65 9.44 68 288747 9179 79446394
Dizziness postural 13.64 9.44 13 288802 11536 79444037
Blood gases abnormal 13.62 9.44 19 288796 1161 79454412
Peripheral vascular disorder 13.61 9.44 6 288809 8024 79447549
Inadequate aseptic technique in use of product 13.58 9.44 7 288808 101 79455472
Acne fulminans 13.58 9.44 9 288806 212 79455361
Hepatitis E 13.53 9.44 32 288783 2954 79452619
Myocardiac abscess 13.50 9.44 5 288810 30 79455543
Type IIb hyperlipidaemia 13.50 9.44 5 288810 30 79455543
Sense of oppression 13.49 9.44 22 288793 1544 79454029
Oral bacterial infection 13.49 9.44 6 288809 61 79455512
Body temperature increased 13.46 9.44 231 288584 44189 79411384
Acid base balance abnormal 13.45 9.44 11 288804 361 79455212
Hepatitis A 13.44 9.44 17 288798 944 79454629
Respiratory gas exchange disorder 13.43 9.44 16 288799 835 79454738
Hypomagnesaemia 13.43 9.44 107 288708 46804 79408769
Small intestinal obstruction 13.41 9.44 52 288763 27220 79428353
Injection site urticaria 13.40 9.44 16 288799 12810 79442763
Foetal growth restriction 13.40 9.44 26 288789 2093 79453480
Extremity necrosis 13.39 9.44 33 288782 3128 79452445
Neuralgia 13.35 9.44 182 288633 33202 79422371
Aeromonas infection 13.34 9.44 11 288804 365 79455208
Meningitis chemical 13.32 9.44 9 288806 219 79455354
Neurosarcoidosis 13.29 9.44 11 288804 367 79455206
Bone loss 13.29 9.44 29 288786 2538 79453035
Chronic hepatitis C 13.26 9.44 14 288801 639 79454934
Ureteric anastomosis complication 13.23 9.44 5 288810 32 79455541
Allergy to plants 13.20 9.44 15 288800 744 79454829
Encephalitis viral 13.20 9.44 29 288786 2550 79453023
Hypofibrinogenaemia 13.20 9.44 25 288790 1977 79453596
Parkinsonism 13.15 9.44 25 288790 16559 79439014
Urinary casts 13.15 9.44 19 288796 1200 79454373
Obesity 13.13 9.44 74 288741 35051 79420522
Lower gastrointestinal haemorrhage 13.06 9.44 24 288791 16101 79439472
Neutropenic sepsis 13.06 9.44 52 288763 27012 79428561
Candida test positive 13.05 9.44 18 288797 1088 79454485
Accelerated idioventricular rhythm 13.01 9.44 9 288806 228 79455345
Eye luxation 13.00 9.44 4 288811 12 79455561
Gastrointestinal pain 12.97 9.44 10 288805 9845 79445728
Tooth injury 12.97 9.44 25 288790 2003 79453570
Dysstasia 12.96 9.44 54 288761 27692 79427881
Coronary arterial stent insertion 12.93 9.44 3 288812 6041 79449532
Mucocutaneous leishmaniasis 12.92 9.44 12 288803 468 79455105
Encephalitis Japanese B 12.92 9.44 6 288809 68 79455505
Autoimmune colitis 12.91 9.44 22 288793 1601 79453972
Intestinal ulcer 12.88 9.44 25 288790 2013 79453560
Hepatic cyst infection 12.88 9.44 8 288807 168 79455405
Pneumatosis 12.87 9.44 16 288799 873 79454700
Haemolysis 12.86 9.44 85 288730 12727 79442846
Coinfection 12.84 9.44 6 288809 69 79455504
Human herpesvirus 6 encephalitis 12.83 9.44 14 288801 664 79454909
Burning sensation 12.82 9.44 143 288672 58489 79397084
Cavernous sinus thrombosis 12.80 9.44 11 288804 387 79455186
Therapeutic product effect incomplete 12.76 9.44 403 288412 141242 79314331
Alternaria infection 12.76 9.44 14 288801 668 79454905
Cryptococcal fungaemia 12.75 9.44 8 288807 171 79455402
Splenic necrosis 12.75 9.44 8 288807 171 79455402
Glomerulonephropathy 12.74 9.44 10 288805 309 79455264
Chronic obstructive pulmonary disease 12.73 9.44 225 288590 85194 79370379
Lupus-like syndrome 12.73 9.44 19 288796 13838 79441735
Unmasking of previously unidentified disease 12.72 9.44 25 288790 2032 79453541
Intestinal intraepithelial lymphocytes increased 12.71 9.44 8 288807 172 79455401
Cerebellar ataxia 12.68 9.44 24 288791 1897 79453676
Mean cell haemoglobin concentration increased 12.67 9.44 16 288799 887 79454686
Hyperoxaluria 12.63 9.44 10 288805 313 79455260
Gynaecomastia 12.62 9.44 6 288809 7675 79447898
Acute endocarditis 12.62 9.44 5 288810 37 79455536
Pathergy reaction 12.62 9.44 5 288810 37 79455536
Bronchostenosis 12.61 9.44 14 288801 677 79454896
Epididymitis 12.60 9.44 24 288791 1906 79453667
Interleukin-2 receptor increased 12.58 9.44 9 288806 241 79455332
Optic atrophy 12.57 9.44 24 288791 1909 79453664
Hallucination, auditory 12.55 9.44 36 288779 20657 79434916
Carotid artery occlusion 12.52 9.44 6 288809 7641 79447932
Thrombotic thrombocytopenic purpura 12.50 9.44 51 288764 6325 79449248
Chronic papillomatous dermatitis 12.47 9.44 6 288809 74 79455499
Myelocyte percentage increased 12.45 9.44 9 288806 245 79455328
Lymphangitis 12.43 9.44 20 288795 1388 79454185
Hepatitis toxic 12.43 9.44 44 288771 5103 79450470
Subdural haematoma 12.42 9.44 65 288750 31369 79424204
Clostridium colitis 12.41 9.44 30 288785 2809 79452764
Anti-cyclic citrullinated peptide antibody 12.33 9.44 3 288812 5849 79449724
Interstitial lung disease 12.32 9.44 512 288303 112088 79343485
Optic nerve compression 12.32 9.44 4 288811 15 79455558
Germ cell cancer 12.31 9.44 8 288807 182 79455391
Excessive skin 12.27 9.44 7 288808 125 79455448
Fungal sepsis 12.25 9.44 23 288792 1807 79453766
Gastroduodenal ulcer 12.22 9.44 12 288803 502 79455071
Febrile neutropenia 12.21 9.44 698 288117 230301 79225272
Pallor 12.21 9.44 119 288696 49943 79405630
Diarrhoea haemorrhagic 12.21 9.44 86 288729 13148 79442425
Paradoxical drug reaction 12.19 9.44 55 288760 7130 79448443
Cancer in remission 12.18 9.44 5 288810 41 79455532
Sensitivity to weather change 12.16 9.44 7 288808 8040 79447533
Creatinine urine decreased 12.14 9.44 9 288806 255 79455318
Eye abscess 12.12 9.44 10 288805 332 79455241
Carotid artery insufficiency 12.12 9.44 4 288811 16 79455557
Renal artery perforation 12.12 9.44 4 288811 16 79455557
Multiple fractures 12.10 9.44 7 288808 8019 79447554
Monocyte count decreased 12.08 9.44 32 288783 3169 79452404
Chronic graft versus host disease in skin 12.08 9.44 21 288794 1553 79454020
White blood cell count increased 12.08 9.44 355 288460 74278 79381295
Haematuria traumatic 12.05 9.44 8 288807 189 79455384
Paraplegia 12.04 9.44 43 288772 5010 79450563
Panic attack 12.02 9.44 46 288769 24170 79431403
Spinal cord infarction 12.02 9.44 13 288802 610 79454963
Gastritis fungal 12.01 9.44 8 288807 190 79455383
Allergy test positive 12.01 9.44 14 288801 714 79454859
Complication of device insertion 12.00 9.44 4 288811 6346 79449227
Femoral nerve palsy 12.00 9.44 6 288809 81 79455492
Lactic acidosis 11.92 9.44 181 288634 70178 79385395
Abdominal pain 11.91 9.44 1232 287583 388337 79067236
Epistaxis 11.89 9.44 310 288505 111205 79344368
Hepatic artery aneurysm 11.87 9.44 5 288810 44 79455529
Mucosal ulceration 11.87 9.44 23 288792 1850 79453723
Viral load abnormal 11.87 9.44 6 288809 83 79455490
Hyperferritinaemia 11.84 9.44 14 288801 725 79454848
Muscle abscess 11.79 9.44 17 288798 1071 79454502
Vaginal haemorrhage 11.79 9.44 40 288775 21777 79433796
Anastomotic haemorrhage 11.78 9.44 9 288806 267 79455306
Hypoaesthesia 11.78 9.44 530 288285 178822 79276751
Multisystem inflammatory syndrome in children 11.77 9.44 5 288810 45 79455528
Citrobacter infection 11.77 9.44 16 288799 954 79454619
Retroperitoneal haematoma 11.71 9.44 44 288771 5253 79450320
Dislocation of vertebra 11.70 9.44 7 288808 7873 79447700
Mycobacterium avium complex infection 11.70 9.44 40 288775 4560 79451013
Aortic pseudoaneurysm 11.68 9.44 5 288810 46 79455527
Pneumonia 11.64 9.44 2630 286185 657616 78797957
Fibrin D dimer increased 11.64 9.44 62 288753 8592 79446981
Cytomegalovirus mucocutaneous ulcer 11.62 9.44 6 288809 87 79455486
Eye pruritus 11.61 9.44 37 288778 20533 79435040
Product complaint 11.60 9.44 19 288796 13330 79442243
Mean cell haemoglobin decreased 11.59 9.44 49 288766 6175 79449398
Stomatitis necrotising 11.59 9.44 8 288807 202 79455371
X-ray limb abnormal 11.57 9.44 4 288811 19 79455554
Withdrawal syndrome 11.49 9.44 54 288761 26800 79428773
Perinephric collection 11.46 9.44 10 288805 359 79455214
Dysarthria 11.44 9.44 174 288641 67448 79388125
Pneumonia aspiration 11.44 9.44 172 288643 66795 79388778
Chromoblastomycosis 11.44 9.44 6 288809 90 79455483
Nephrogenic systemic fibrosis 11.44 9.44 4 288811 6156 79449417
Acinetobacter bacteraemia 11.41 9.44 9 288806 280 79455293
Mixed liver injury 11.38 9.44 56 288759 7522 79448051
Chest discomfort 11.33 9.44 610 288205 137434 79318139
Genital herpes 11.31 9.44 24 288791 2060 79453513
Complement factor C3 decreased 11.25 9.44 10 288805 368 79455205
Bone marrow disorder 11.21 9.44 32 288783 3311 79452262
Bacterial pyelonephritis 11.20 9.44 12 288803 557 79455016
Blood creatine phosphokinase increased 11.20 9.44 170 288645 65920 79389653
Pancreatic carcinoma 11.18 9.44 20 288795 13557 79442016
Substance abuse 11.14 9.44 13 288802 10513 79445060
Hypocomplementaemia 11.12 9.44 8 288807 216 79455357
Cells in urine 11.12 9.44 8 288807 216 79455357
Angioedema 11.11 9.44 201 288614 75834 79379739
Disseminated trichosporonosis 11.10 9.44 7 288808 151 79455422
Live birth 11.09 9.44 33 288782 18711 79436862
Refractory anaemia with an excess of blasts 11.08 9.44 15 288800 891 79454682
Thrombosis in device 11.06 9.44 3 288812 5439 79450134
Haemorrhagic necrotic pancreatitis 11.06 9.44 7 288808 152 79455421
Conus medullaris syndrome 11.06 9.44 5 288810 53 79455520
Vascular rupture 11.06 9.44 21 288794 1664 79453909
Wrist deformity 11.05 9.44 24 288791 2093 79453480
Muscle rigidity 11.05 9.44 36 288779 19846 79435727
Hairy cell leukaemia 11.04 9.44 6 288809 97 79455476
Wolff-Parkinson-White syndrome 11.04 9.44 9 288806 294 79455279
Dental caries 11.01 9.44 77 288738 11743 79443830
Injection site discolouration 10.98 9.44 7 288808 7607 79447966
Tuberculosis of genitourinary system 10.98 9.44 5 288810 54 79455519
Type I hypersensitivity 10.97 9.44 38 288777 4360 79451213
Urinoma 10.96 9.44 8 288807 221 79455352
Blood creatinine increased 10.96 9.44 676 288139 154381 79301192
Central pain syndrome 10.96 9.44 9 288806 297 79455276
Shock 10.94 9.44 220 288595 43328 79412245
Monocyte percentage decreased 10.93 9.44 9 288806 298 79455275
Alopecia scarring 10.93 9.44 6 288809 99 79455474
Pneumonia influenzal 10.93 9.44 29 288786 2875 79452698
Enterococcal bacteraemia 10.91 9.44 30 288785 3038 79452535
Dry throat 10.91 9.44 56 288759 7650 79447923
Chorioretinitis 10.91 9.44 16 288799 1024 79454549
Nephrolithiasis 10.86 9.44 132 288683 53159 79402414
Optic nerve operation 10.84 9.44 11 288804 479 79455094
Asphyxia 10.84 9.44 16 288799 11704 79443869
Rash erythematous 10.82 9.44 280 288535 57489 79398084
Eosinophil percentage decreased 10.81 9.44 9 288806 303 79455270
Schizophrenia 10.80 9.44 25 288790 15415 79440158
Ageusia 10.79 9.44 28 288787 16604 79438969
Vitello-intestinal duct remnant 10.78 9.44 7 288808 159 79455414
Pancreatitis 10.75 9.44 179 288636 68396 79387177
Obsessive-compulsive disorder 10.75 9.44 4 288811 5923 79449650
Phaeohyphomycotic brain abscess 10.74 9.44 5 288810 57 79455516
Bronchial anastomosis complication 10.74 9.44 5 288810 57 79455516
Hereditary angioedema 10.74 9.44 3 288812 5332 79450241
Hepatitis viral 10.70 9.44 16 288799 1042 79454531
Bile duct stenosis 10.69 9.44 23 288792 1993 79453580
Thrombocytopenic purpura 10.69 9.44 26 288789 2443 79453130
Oropharyngeal plaque 10.68 9.44 10 288805 394 79455179
Adrenal atrophy 10.66 9.44 5 288810 58 79455515
Castleman's disease 10.66 9.44 4 288811 25 79455548
Neuromyotonia 10.62 9.44 6 288809 105 79455468
Hyperpyrexia 10.61 9.44 47 288768 6045 79449528
Osseous cryptococcosis 10.60 9.44 3 288812 6 79455567
Glomerulonephritis proliferative 10.60 9.44 10 288805 398 79455175
Haemangioma-thrombocytopenia syndrome 10.60 9.44 3 288812 6 79455567
Blood magnesium decreased 10.56 9.44 28 288787 16484 79439089
Laboratory test abnormal 10.53 9.44 59 288756 27989 79427584
Platelet count decreased 10.51 9.44 587 288228 194077 79261496
Hepatitis acute 10.49 9.44 94 288721 15448 79440125
Cardiogenic shock 10.49 9.44 99 288716 41815 79413758
Retinal depigmentation 10.49 9.44 9 288806 316 79455257
Stupor 10.48 9.44 51 288764 6821 79448752
Scrotal infection 10.47 9.44 12 288803 601 79454972
Behaviour disorder 10.46 9.44 48 288767 6265 79449308
Tick-borne viral encephalitis 10.45 9.44 7 288808 168 79455405
Familial periodic paralysis 10.45 9.44 7 288808 168 79455405
Cardiac pacemaker insertion 10.44 9.44 4 288811 5818 79449755
Gastrointestinal perforation 10.42 9.44 47 288768 6090 79449483
Atrioventricular block 10.42 9.44 22 288793 14019 79441554
Nose deformity 10.41 9.44 7 288808 169 79455404
Endometrial disorder 10.41 9.44 12 288803 605 79454968
Abnormal loss of weight 10.40 9.44 9 288806 8367 79447206
Oral discomfort 10.39 9.44 12 288803 9748 79445825
Bundle branch block left 10.37 9.44 16 288799 11497 79444076
Arterial thrombosis 10.37 9.44 27 288788 2647 79452926
Influenza like illness 10.33 9.44 190 288625 71517 79384056
Splenic infection fungal 10.33 9.44 6 288809 111 79455462
Hypoxia 10.30 9.44 465 288350 102778 79352795
Depressed mood 10.30 9.44 119 288696 48361 79407212
Magnesium deficiency 10.30 9.44 12 288803 612 79454961
Acute myeloid leukaemia (in remission) 10.28 9.44 4 288811 28 79455545
Back pain 10.27 9.44 955 287860 303225 79152348
Fracture pain 10.26 9.44 13 288802 723 79454850
Presyncope 10.26 9.44 97 288718 40957 79414616
Blood pressure systolic decreased 10.23 9.44 72 288743 11004 79444569
Second primary malignancy 10.22 9.44 23 288792 14327 79441246
Syringe issue 10.22 9.44 5 288810 6293 79449280
Retinal scar 10.19 9.44 10 288805 418 79455155
Granuloma 10.19 9.44 58 288757 8239 79447334
Biliary anastomosis complication 10.16 9.44 7 288808 176 79455397
Catheterisation cardiac 10.16 9.44 4 288811 5724 79449849
Faciobrachial dystonic seizure 10.16 9.44 5 288810 65 79455508
White coat hypertension 10.16 9.44 14 288801 846 79454727
Retching 10.15 9.44 31 288784 17436 79438137
Haemorrhoidal haemorrhage 10.14 9.44 6 288809 6789 79448784
Squamous cell carcinoma of the cervix 10.14 9.44 8 288807 249 79455324
Biopsy lymph gland 10.14 9.44 6 288809 115 79455458
Coombs direct test positive 10.13 9.44 10 288805 421 79455152
Groin pain 10.13 9.44 20 288795 13060 79442513
Device failure 10.12 9.44 5 288810 6256 79449317
Pterygium 10.11 9.44 9 288806 332 79455241
Diffuse mesangial sclerosis 10.10 9.44 5 288810 66 79455507
Moraxella infection 10.09 9.44 12 288803 625 79454948
Leiomyoma 10.09 9.44 9 288806 333 79455240
Necrotising oesophagitis 10.09 9.44 16 288799 1097 79454476
Eosinophil percentage increased 10.06 9.44 19 288796 1499 79454074
Renal tubular injury 10.05 9.44 19 288796 1500 79454073
Sebaceous carcinoma 10.00 9.44 6 288809 118 79455455
Pneumonitis 9.99 9.44 290 288525 60570 79395003
Salivary gland mass 9.96 9.44 5 288810 68 79455505
Thyroid stimulating immunoglobulin 9.96 9.44 5 288810 68 79455505
Anuria 9.96 9.44 118 288697 20845 79434728
SARS-CoV-2 RNA 9.93 9.44 4 288811 31 79455542
Oral fungal infection 9.92 9.44 33 288782 3710 79451863
Sinus node dysfunction 9.90 9.44 8 288807 7693 79447880
Tri-iodothyronine free increased 9.90 9.44 8 288807 258 79455315
Renal atrophy 9.89 9.44 21 288794 1804 79453769
Drug hypersensitivity 9.87 9.44 940 287875 297976 79157597
ADAMTS13 activity decreased 9.86 9.44 7 288808 185 79455388
Spinal cord abscess 9.83 9.44 10 288805 437 79455136
Paralogism 9.83 9.44 4 288811 32 79455541
CD8 lymphocytes decreased 9.82 9.44 8 288807 261 79455312
Vein disorder 9.81 9.44 41 288774 5141 79450432
Neuropathy peripheral 9.80 9.44 415 288400 140890 79314683
Breast cancer metastatic 9.79 9.44 10 288805 8592 79446981
Nail bed inflammation 9.79 9.44 11 288804 539 79455034
Histiocytic sarcoma 9.77 9.44 5 288810 71 79455502
Lymphocyte count increased 9.76 9.44 45 288770 5887 79449686
Bacterial translocation 9.72 9.44 12 288803 650 79454923
Respiratory tract infection 9.71 9.44 238 288577 48451 79407122
Immunoglobulins decreased 9.69 9.44 19 288796 1541 79454032
Bulbar palsy 9.69 9.44 8 288807 266 79455307
Tooth disorder 9.68 9.44 141 288674 26092 79429481
Laryngeal mass 9.65 9.44 5 288810 73 79455500
Blood 1,25-dihydroxycholecalciferol increased 9.62 9.44 4 288811 34 79455539
Normochromic anaemia 9.61 9.44 10 288805 449 79455124
Urinary tract infection enterococcal 9.59 9.44 30 288785 3265 79452308
Linear IgA disease 9.57 9.44 29 288786 3103 79452470
Glomerulonephritis chronic 9.56 9.44 8 288807 271 79455302
Joint stiffness 9.56 9.44 98 288717 40732 79414841
Aspiration 9.56 9.44 39 288776 20119 79435454
Donor specific antibody present 9.54 9.44 8 288807 272 79455301
Occult blood 9.54 9.44 20 288795 1703 79453870
Hepatic encephalopathy 9.53 9.44 50 288765 24116 79431457
Cytomegalovirus gastroenteritis 9.52 9.44 10 288805 454 79455119
Spinal stroke 9.52 9.44 4 288811 35 79455538
Lower motor neurone lesion 9.52 9.44 4 288811 35 79455538
Haematochezia 9.51 9.44 243 288572 87402 79368171
Lower respiratory tract congestion 9.51 9.44 34 288781 3963 79451610
Panniculitis 9.51 9.44 19 288796 12352 79443221
Bursitis infective 9.50 9.44 17 288798 1287 79454286
Liver disorder 9.49 9.44 195 288620 72222 79383351
Haemoglobin abnormal 9.49 9.44 7 288808 7047 79448526
Cardiovascular insufficiency 9.48 9.44 28 288787 2953 79452620
Asymptomatic bacteriuria 9.48 9.44 9 288806 361 79455212
Expired product administered 9.48 9.44 7 288808 7044 79448529
Tenosynovitis 9.48 9.44 27 288788 15527 79440046
Waxy flexibility 9.46 9.44 8 288807 275 79455298
Eosinophilic granulomatosis with polyangiitis 9.46 9.44 32 288783 3628 79451945
Diabetic hyperosmolar coma 9.45 9.44 13 288802 784 79454789

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D07AA01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, weak (group I)
ATC D07CA02 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, weak, combinations with antibiotics
ATC D10AA02 DERMATOLOGICALS
ANTI-ACNE PREPARATIONS
ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Corticosteroids, combinations for treatment of acne
ATC H02AB04 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
ATC H02BX01 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, COMBINATIONS
Corticosteroids for systemic use, combinations
ATC S01CA08 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S03CA07 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000932 Antiemetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D018696 Neuroprotective Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:37962 adrenergic agents
CHEBI has role CHEBI:50919 antiemetico
CHEBI has role CHEBI:63726 neuroprotective agents
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Cerebral edema indication 2032001
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Tendinitis indication 34840004 DOID:971
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Miliary tuberculosis indication 47604008 DOID:9861
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Seborrheic dermatitis indication 50563003 DOID:8741
Edema of larynx indication 51599000
Nephrotic syndrome indication 52254009 DOID:1184
Lichen simplex chronicus indication 53891004
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Löffler's syndrome indication 64936001 DOID:9503
Pemphigus indication 65172003 DOID:9182
Granuloma annulare indication 65508009 DOID:3777
Tenosynovitis indication 67801009 DOID:970
Rheumatoid arthritis indication 69896004 DOID:7148
Transfusion reaction due to serum protein reaction indication 72284000
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Thyroiditis indication 82119001 DOID:7166
Bursitis indication 84017003 DOID:2965
Autoimmune disease indication 85828009
Infection by larvae of Trichinella spiralis indication 88264003
Congenital hypoplastic anemia indication 88854002 DOID:1339
Pruritus ani indication 90446007
Acute lymphoid leukemia indication 91857003 DOID:9952
Disorder of skin indication 95320005 DOID:37
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Mycosis fungoides indication 118618005
Aspiration pneumonitis indication 155597006
Asthma indication 195967001 DOID:2841
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Transplanted organ rejection indication 213148006
Congenital adrenal hyperplasia indication 237751000
Scalp psoriasis indication 238608008
Adrenogenital disorder indication 267395000 DOID:0050811
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Exacerbation of asthma indication 281239006
Follicular non-Hodgkin's lymphoma indication 308121000
Disorder of eye indication 371405004 DOID:5614
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Juvenile rheumatoid arthritis indication 410795001
Autoimmune hemolytic anemia indication 413603009 DOID:718
Synovitis indication 416209007 DOID:2703
Post traumatic osteoarthritis indication 699262001
Systemic Dermatomyositis indication
Diagnostic Test for Cushing's Syndrome indication
Synovitis due to Osteoarthritis indication
Transfusion Reaction Urticaria indication
Progressive Diffuse Large B-Cell Lymphoma indication
Erythroblastic Anemia indication
Pericarditis off-label use 3238004 DOID:1787
Chronic obstructive lung disease off-label use 13645005 DOID:3083
Pulmonary edema off-label use 19242006 DOID:11396
Shock off-label use 27942005
West syndrome off-label use 28055006
Vasculitis off-label use 31996006 DOID:865
Bronchitis off-label use 32398004 DOID:6132
Anaphylaxis off-label use 39579001
Eczema off-label use 43116000
Respiratory distress syndrome in the newborn off-label use 46775006
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Polymyalgia rheumatica off-label use 65323003 DOID:853
Chronic hepatitis off-label use 76783007 DOID:2237
Pemphigoid off-label use 86142006
Hepatic necrosis off-label use 87248009
Multiple myeloma off-label use 109989006 DOID:9538
Polyarteritis nodosa off-label use 155441006 DOID:9810
Coronavirus infection off-label use 186747009
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Giant cell arteritis off-label use 414341000 DOID:13375
Neonatal Bronchopulmonary Dysplasia off-label use
Prevention of Post-Extubation Laryngeal Edema off-label use
Metastatic Prostate Carcinoma off-label use
Hypercalcemia associated with Sarcoidosis off-label use
Neuroendocrine Prostate Carcinoma off-label use
Prevention of Lung Transplant Rejection off-label use
Prevention of Cardiac Transplant Rejection off-label use
Infection by Strongyloides contraindication 1214006 DOID:10955
Mycosis contraindication 3218000 DOID:1564
Gastritis contraindication 4556007 DOID:4029
Inactive tuberculosis contraindication 11999007
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Congenital hyperammonemia, type I contraindication 62522004
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Hyperglycemia contraindication 80394007 DOID:4195
Ornithine Carbamyltransferase Deficiency contraindication 80908008 DOID:9271
Open-angle glaucoma contraindication 84494001 DOID:1067
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Bilateral cataracts contraindication 95722004
Seizure disorder contraindication 128613002
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Skin striae contraindication 201066002
Anastomosis of intestine contraindication 235407009
Telangiectasia disorder contraindication 247479008
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Pregnancy, function contraindication 289908002
Varicella-zoster virus infection contraindication 309465005
Osteopenia contraindication 312894000
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Atrophoderma contraindication 399979006
Traumatic rupture of tendon contraindication 415749005
Exposure to varicella contraindication 444453009
Arginosuccinate Lyase Deficiency contraindication




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Inflammation and related disorders Indication
Cats Allergic and dermatologic disorders Indication
Cats Supportive therapy to antibacterial treatment of severe infections Indication
Dogs Inflammation and related disorders Indication
Dogs Allergic and dermatologic disorders Indication
Dogs Supportive therapy to antibacterial treatment of severe infections Indication
Horses Inflammation and related disorders Indication

🐶 Veterinary products

ProductApplicantIngredients
Medrol Tablets Zoetis Inc. 1
Cortaba Tablets Zoetis Inc. 2
Methylprednisolene Tablets Cronus Pharma Specialities India Private Limited 1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.18 acidic
pKa2 12.89 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST EC50 8.50 WOMBAT-PK CHEMBL
Annexin A1 Cytosolic other WOMBAT-PK
Short transient receptor potential channel 5 Ion channel ACTIVATOR EC50 4.92 IUPHAR
Androgen receptor Transcription factor Ki 4.75 DRUG MATRIX

External reference:

IDSource
4018068 VUID
N0000146409 NUI
D00407 KEGG_DRUG
4018068 VANDF
C0025815 UMLSCUI
CHEBI:6888 CHEBI
CHEMBL1201081 ChEMBL_ID
CHEMBL650 ChEMBL_ID
DB00959 DRUGBANK_ID
D008775 MESH_DESCRIPTOR_UI
6741 PUBCHEM_CID
7088 IUPHAR_LIGAND_ID
732 INN_ID
X4W7ZR7023 UNII
6902 RXNORM
1041 MMSL
5093 MMSL
7130 MMSL
d00293 MMSL
002160 NDDF
116593003 SNOMEDCT_US
27242001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0020 TABLET 2 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0020 TABLET 2 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0022 TABLET 8 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0022 TABLET 8 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0049 TABLET 2 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0049 TABLET 2 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0056 TABLET 4 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0056 TABLET 4 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0073 TABLET 16 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0073 TABLET 16 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0176 TABLET 32 mg ORAL NDA 16 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 0009-0176 TABLET 32 mg ORAL NDA 16 sections
MethylPREDNISolone HUMAN PRESCRIPTION DRUG LABEL 1 0603-4593 TABLET 4 mg ORAL ANDA 13 sections
MethylPREDNISolone HUMAN PRESCRIPTION DRUG LABEL 1 0603-4593 TABLET 4 mg ORAL ANDA 13 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 0781-5022 TABLET 4 mg ORAL ANDA 15 sections
methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 0904-6914 TABLET 4 mg ORAL ANDA 13 sections
METHYLPREDNISOLONE HUMAN PRESCRIPTION DRUG LABEL 1 16590-149 TABLET 4 mg ORAL ANDA 11 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 16590-879 TABLET 4 mg ORAL NDA 11 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 21695-080 TABLET 4 mg ORAL ANDA 12 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 33261-335 TABLET 4 mg ORAL ANDA 12 sections
METHYLPREDNISOLONE HUMAN PRESCRIPTION DRUG LABEL 1 42549-522 TABLET 4 mg ORAL ANDA 12 sections
METHYLPREDNISOLONE HUMAN PRESCRIPTION DRUG LABEL 1 42806-400 TABLET 4 mg ORAL ANDA 15 sections
METHYLPREDNISOLONE HUMAN PRESCRIPTION DRUG LABEL 1 42806-400 TABLET 4 mg ORAL ANDA 15 sections
METHYLPREDNISOLONE HUMAN PRESCRIPTION DRUG LABEL 1 42806-400 TABLET 4 mg ORAL ANDA 15 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 45865-104 TABLET 4 mg ORAL ANDA 15 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 45865-417 TABLET 4 mg ORAL ANDA 12 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 49999-153 TABLET 4 mg ORAL NDA 14 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 49999-153 TABLET 4 mg ORAL NDA 14 sections
Methylprednisolone HUMAN PRESCRIPTION DRUG LABEL 1 49999-153 TABLET 4 mg ORAL NDA 14 sections
Medrol HUMAN PRESCRIPTION DRUG LABEL 1 50090-0092 TABLET 4 mg ORAL NDA 15 sections