Stem definition | Drug id | CAS RN |
---|---|---|
1767 | 113-45-1 |
Dose | Unit | Route |
---|---|---|
30 | mg | O |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 4.29 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 22 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 2.20 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 9.42 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.85 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 4.80 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 5, 1955 | FDA | NOVARTIS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Suicidal ideation | 287.47 | 10.90 | 272 | 33243 | 56110 | 46596437 |
Product quality issue | 229.06 | 10.90 | 196 | 33319 | 35452 | 46617095 |
Agitation | 186.31 | 10.90 | 214 | 33301 | 55201 | 46597346 |
Anxiety | 186.18 | 10.90 | 406 | 33109 | 181551 | 46470996 |
Product substitution issue | 177.62 | 10.90 | 119 | 33396 | 14912 | 46637635 |
Depression | 166.56 | 10.90 | 373 | 33142 | 169731 | 46482816 |
Aggression | 158.31 | 10.90 | 131 | 33384 | 22613 | 46629934 |
Tachycardia | 156.81 | 10.90 | 267 | 33248 | 99355 | 46553192 |
Disturbance in attention | 145.19 | 10.90 | 144 | 33371 | 31416 | 46621131 |
No adverse event | 137.17 | 10.90 | 145 | 33370 | 34086 | 46618461 |
Abnormal behaviour | 131.59 | 10.90 | 114 | 33401 | 20944 | 46631603 |
Drug abuse | 124.46 | 10.90 | 188 | 33327 | 63220 | 46589327 |
Attention deficit hyperactivity disorder | 121.53 | 10.90 | 49 | 33466 | 2123 | 46650424 |
Tic | 117.07 | 10.90 | 41 | 33474 | 1195 | 46651352 |
Precocious puberty | 112.11 | 10.90 | 27 | 33488 | 192 | 46652355 |
Irritability | 111.35 | 10.90 | 120 | 33395 | 28826 | 46623721 |
Cataplexy | 107.94 | 10.90 | 38 | 33477 | 1125 | 46651422 |
Intentional overdose | 107.35 | 10.90 | 178 | 33337 | 64766 | 46587781 |
Mydriasis | 95.51 | 10.90 | 71 | 33444 | 10482 | 46642065 |
Rheumatoid arthritis | 92.05 | 10.90 | 29 | 33486 | 240186 | 46412361 |
Suicide attempt | 91.15 | 10.90 | 151 | 33364 | 54885 | 46597662 |
Application site erythema | 86.22 | 10.90 | 50 | 33465 | 4854 | 46647693 |
Hallucination, auditory | 85.54 | 10.90 | 67 | 33448 | 10689 | 46641858 |
Pre-existing condition improved | 84.53 | 10.90 | 55 | 33460 | 6557 | 46645990 |
Psychotic disorder | 78.73 | 10.90 | 89 | 33426 | 22532 | 46630015 |
Tremor | 76.73 | 10.90 | 219 | 33296 | 115420 | 46537127 |
Intentional self-injury | 75.60 | 10.90 | 90 | 33425 | 24076 | 46628471 |
Wrong technique in product usage process | 70.36 | 10.90 | 134 | 33381 | 54288 | 46598259 |
Apathy | 68.25 | 10.90 | 50 | 33465 | 7218 | 46645329 |
Product administered at inappropriate site | 66.39 | 10.90 | 33 | 33482 | 2350 | 46650197 |
Therapeutic response unexpected | 64.04 | 10.90 | 67 | 33448 | 15549 | 46636998 |
Overdose | 63.66 | 10.90 | 189 | 33326 | 101790 | 46550757 |
Toxicity to various agents | 63.29 | 10.90 | 310 | 33205 | 211456 | 46441091 |
Rapid eye movement sleep behaviour disorder | 62.62 | 10.90 | 16 | 33499 | 149 | 46652398 |
Acute kidney injury | 62.30 | 10.90 | 47 | 33468 | 235808 | 46416739 |
Application site irritation | 62.23 | 10.90 | 29 | 33486 | 1790 | 46650757 |
Psychomotor hyperactivity | 59.95 | 10.90 | 52 | 33463 | 9561 | 46642986 |
Obsessive-compulsive disorder | 59.78 | 10.90 | 34 | 33481 | 3181 | 46649366 |
Diarrhoea | 58.05 | 10.90 | 207 | 33308 | 559395 | 46093152 |
Insomnia | 57.02 | 10.90 | 252 | 33263 | 164672 | 46487875 |
Somnambulism | 55.02 | 10.90 | 38 | 33477 | 4999 | 46647548 |
Bruxism | 53.68 | 10.90 | 31 | 33484 | 2986 | 46649561 |
Anaemia | 53.44 | 10.90 | 63 | 33452 | 255716 | 46396831 |
Hallucination | 52.65 | 10.90 | 113 | 33402 | 49838 | 46602709 |
Enuresis | 50.75 | 10.90 | 26 | 33489 | 1974 | 46650573 |
Feeling abnormal | 50.16 | 10.90 | 200 | 33315 | 124860 | 46527687 |
Product administration error | 49.91 | 10.90 | 66 | 33449 | 19615 | 46632932 |
Educational problem | 49.73 | 10.90 | 15 | 33500 | 268 | 46652279 |
Drug dependence | 49.33 | 10.90 | 66 | 33449 | 19835 | 46632712 |
Dystonia | 49.23 | 10.90 | 50 | 33465 | 11207 | 46641340 |
Product colour issue | 48.19 | 10.90 | 18 | 33497 | 633 | 46651914 |
Sleep apnoea syndrome | 46.63 | 10.90 | 68 | 33447 | 22133 | 46630414 |
Impulsive behaviour | 45.25 | 10.90 | 22 | 33493 | 1493 | 46651054 |
Social anxiety disorder | 45.04 | 10.90 | 15 | 33500 | 374 | 46652173 |
Muscle twitching | 44.82 | 10.90 | 54 | 33461 | 14618 | 46637929 |
Growth retardation | 44.81 | 10.90 | 19 | 33496 | 936 | 46651611 |
Neutropenia | 43.98 | 10.90 | 24 | 33491 | 143180 | 46509367 |
Joint swelling | 42.67 | 10.90 | 34 | 33481 | 166039 | 46486508 |
Somnolence | 42.40 | 10.90 | 223 | 33292 | 156298 | 46496249 |
Muscle contracture | 41.56 | 10.90 | 20 | 33495 | 1327 | 46651220 |
Bipolar disorder | 41.11 | 10.90 | 37 | 33478 | 7140 | 46645407 |
Panic attack | 41.07 | 10.90 | 61 | 33454 | 20181 | 46632366 |
Febrile neutropenia | 40.79 | 10.90 | 9 | 33506 | 94618 | 46557929 |
Parasomnia | 40.20 | 10.90 | 14 | 33501 | 401 | 46652146 |
Drug diversion | 39.97 | 10.90 | 17 | 33498 | 844 | 46651703 |
Pulmonary malformation | 38.96 | 10.90 | 10 | 33505 | 95 | 46652452 |
Splenic infarction | 38.63 | 10.90 | 20 | 33495 | 1552 | 46650995 |
Application site pruritus | 38.57 | 10.90 | 28 | 33487 | 3985 | 46648562 |
Headache | 38.38 | 10.90 | 517 | 32998 | 477835 | 46174712 |
Contraindicated product administered | 37.88 | 10.90 | 6 | 33509 | 79941 | 46572606 |
Arthralgia | 37.60 | 10.90 | 135 | 33380 | 364468 | 46288079 |
Intentional product misuse | 36.97 | 10.90 | 95 | 33420 | 47033 | 46605514 |
Death | 36.79 | 10.90 | 121 | 33394 | 335427 | 46317120 |
Haemoglobin decreased | 36.24 | 10.90 | 24 | 33491 | 128925 | 46523622 |
Affective disorder | 36.15 | 10.90 | 29 | 33486 | 4786 | 46647761 |
Dyskinesia | 34.66 | 10.90 | 69 | 33446 | 28856 | 46623691 |
Memory impairment | 34.52 | 10.90 | 128 | 33387 | 77209 | 46575338 |
Dyspnoea | 34.45 | 10.90 | 223 | 33292 | 515325 | 46137222 |
Hallucination, visual | 33.62 | 10.90 | 52 | 33463 | 17821 | 46634726 |
Anger | 33.58 | 10.90 | 42 | 33473 | 11810 | 46640737 |
Application site urticaria | 33.54 | 10.90 | 11 | 33504 | 261 | 46652286 |
Depressed mood | 33.53 | 10.90 | 74 | 33441 | 33245 | 46619302 |
Delusion of parasitosis | 33.29 | 10.90 | 6 | 33509 | 6 | 46652541 |
Crying | 32.32 | 10.90 | 56 | 33459 | 21085 | 46631462 |
Narcolepsy | 32.14 | 10.90 | 16 | 33499 | 1143 | 46651404 |
Livedo reticularis | 31.99 | 10.90 | 20 | 33495 | 2224 | 46650323 |
Exposure during pregnancy | 31.95 | 10.90 | 158 | 33357 | 108054 | 46544493 |
Withdrawal syndrome | 31.68 | 10.90 | 51 | 33464 | 18083 | 46634464 |
Respiratory tract malformation | 31.65 | 10.90 | 8 | 33507 | 71 | 46652476 |
Feeling jittery | 31.18 | 10.90 | 39 | 33476 | 10969 | 46641578 |
Sepsis | 31.14 | 10.90 | 31 | 33484 | 135983 | 46516564 |
Multiple sclerosis relapse | 31.08 | 10.90 | 83 | 33432 | 42042 | 46610505 |
Paranoia | 30.74 | 10.90 | 38 | 33477 | 10559 | 46641988 |
Restlessness | 30.72 | 10.90 | 61 | 33454 | 25463 | 46627084 |
Hyperventilation | 30.17 | 10.90 | 28 | 33487 | 5619 | 46646928 |
Solar urticaria | 29.95 | 10.90 | 7 | 33508 | 43 | 46652504 |
Pneumonia | 29.80 | 10.90 | 154 | 33361 | 376166 | 46276381 |
Seizure | 29.73 | 10.90 | 170 | 33345 | 122884 | 46529663 |
Emotional disorder | 29.21 | 10.90 | 40 | 33475 | 12284 | 46640263 |
Completed suicide | 29.20 | 10.90 | 192 | 33323 | 145728 | 46506819 |
Drug hypersensitivity | 28.76 | 10.90 | 85 | 33430 | 243740 | 46408807 |
Heart rate increased | 28.67 | 10.90 | 118 | 33397 | 74673 | 46577874 |
Lung cyst | 28.54 | 10.90 | 8 | 33507 | 109 | 46652438 |
Mania | 28.47 | 10.90 | 37 | 33478 | 10809 | 46641738 |
Cardiac failure | 28.25 | 10.90 | 11 | 33504 | 79937 | 46572610 |
Infection | 27.76 | 10.90 | 33 | 33482 | 133559 | 46518988 |
Negative thoughts | 27.75 | 10.90 | 13 | 33502 | 812 | 46651735 |
Thrombocytopenia | 27.68 | 10.90 | 30 | 33485 | 126551 | 46525996 |
Cardiac failure congestive | 27.26 | 10.90 | 16 | 33499 | 91734 | 46560813 |
Meningitis streptococcal | 26.68 | 10.90 | 8 | 33507 | 140 | 46652407 |
Amphetamines positive | 26.59 | 10.90 | 7 | 33508 | 74 | 46652473 |
Pancytopenia | 26.48 | 10.90 | 14 | 33501 | 85044 | 46567503 |
Wound infection fungal | 26.42 | 10.90 | 7 | 33508 | 76 | 46652471 |
Euphoric mood | 26.42 | 10.90 | 23 | 33492 | 4249 | 46648298 |
Snoring | 26.41 | 10.90 | 21 | 33494 | 3421 | 46649126 |
Optic disc haemorrhage | 25.79 | 10.90 | 6 | 33509 | 36 | 46652511 |
Serotonin syndrome | 25.75 | 10.90 | 55 | 33460 | 24165 | 46628382 |
Interstitial lung disease | 25.67 | 10.90 | 4 | 33511 | 53945 | 46598602 |
Swelling | 25.61 | 10.90 | 31 | 33484 | 124480 | 46528067 |
Post-traumatic stress disorder | 25.45 | 10.90 | 22 | 33493 | 4026 | 46648521 |
Pre-eclampsia | 25.37 | 10.90 | 30 | 33485 | 7964 | 46644583 |
Hypersomnia | 25.05 | 10.90 | 42 | 33473 | 15397 | 46637150 |
Tachyphrenia | 24.91 | 10.90 | 14 | 33501 | 1280 | 46651267 |
Renal failure | 24.75 | 10.90 | 27 | 33488 | 113567 | 46538980 |
Sleep-related eating disorder | 24.75 | 10.90 | 11 | 33504 | 608 | 46651939 |
Mood altered | 24.69 | 10.90 | 38 | 33477 | 12969 | 46639578 |
Peripheral swelling | 24.24 | 10.90 | 48 | 33467 | 158023 | 46494524 |
Multiple organ dysfunction syndrome | 24.23 | 10.90 | 4 | 33511 | 51706 | 46600841 |
Lower respiratory tract infection | 24.23 | 10.90 | 5 | 33510 | 55084 | 46597463 |
Migraine | 24.15 | 10.90 | 107 | 33408 | 69919 | 46582628 |
Gastrointestinal haemorrhage | 23.69 | 10.90 | 13 | 33502 | 77360 | 46575187 |
Maternal exposure during breast feeding | 23.54 | 10.90 | 18 | 33497 | 2771 | 46649776 |
Psychiatric symptom | 23.45 | 10.90 | 22 | 33493 | 4475 | 46648072 |
Tachypnoea | 23.23 | 10.90 | 39 | 33476 | 14312 | 46638235 |
Product prescribing error | 23.03 | 10.90 | 47 | 33468 | 20000 | 46632547 |
Eosinophilic myocarditis | 22.90 | 10.90 | 9 | 33506 | 364 | 46652183 |
Drug screen negative | 22.67 | 10.90 | 9 | 33506 | 374 | 46652173 |
Perinatal depression | 22.58 | 10.90 | 10 | 33505 | 548 | 46651999 |
Application site rash | 22.53 | 10.90 | 17 | 33498 | 2565 | 46649982 |
Axonal neuropathy | 22.49 | 10.90 | 12 | 33503 | 990 | 46651557 |
Septic shock | 22.11 | 10.90 | 7 | 33508 | 57886 | 46594661 |
Product taste abnormal | 21.89 | 10.90 | 15 | 33500 | 1948 | 46650599 |
Glossodynia | 21.78 | 10.90 | 3 | 33512 | 44370 | 46608177 |
Chronic fatigue syndrome | 21.74 | 10.90 | 12 | 33503 | 1059 | 46651488 |
Weight decreased | 21.65 | 10.90 | 239 | 33276 | 210610 | 46441937 |
Logorrhoea | 21.63 | 10.90 | 16 | 33499 | 2343 | 46650204 |
Hyperkalaemia | 21.49 | 10.90 | 5 | 33510 | 50704 | 46601843 |
Open angle glaucoma | 21.48 | 10.90 | 8 | 33507 | 279 | 46652268 |
Atrial fibrillation | 21.08 | 10.90 | 26 | 33489 | 103564 | 46548983 |
Sleep paralysis | 20.87 | 10.90 | 9 | 33506 | 462 | 46652085 |
Renal impairment | 20.67 | 10.90 | 14 | 33501 | 74358 | 46578189 |
Burnout syndrome | 20.46 | 10.90 | 7 | 33508 | 190 | 46652357 |
Protrusion tongue | 20.21 | 10.90 | 8 | 33507 | 330 | 46652217 |
Infusion related reaction | 19.97 | 10.90 | 26 | 33489 | 101182 | 46551365 |
Abnormal sleep-related event | 19.80 | 10.90 | 10 | 33505 | 737 | 46651810 |
General physical health deterioration | 19.67 | 10.90 | 33 | 33482 | 115736 | 46536811 |
Treatment failure | 19.32 | 10.90 | 23 | 33492 | 93064 | 46559483 |
Application site discolouration | 19.22 | 10.90 | 10 | 33505 | 784 | 46651763 |
Respiratory failure | 19.08 | 10.90 | 24 | 33491 | 94792 | 46557755 |
Social avoidant behaviour | 19.01 | 10.90 | 16 | 33499 | 2823 | 46649724 |
Pleural effusion | 18.87 | 10.90 | 19 | 33496 | 82933 | 46569614 |
Trichotillomania | 18.72 | 10.90 | 6 | 33509 | 132 | 46652415 |
Compulsive lip biting | 18.72 | 10.90 | 3 | 33512 | 0 | 46652547 |
Bezoar | 18.62 | 10.90 | 12 | 33503 | 1407 | 46651140 |
Mood swings | 18.55 | 10.90 | 38 | 33477 | 16214 | 46636333 |
Learning disorder | 18.37 | 10.90 | 8 | 33507 | 421 | 46652126 |
Incorrect product administration duration | 18.20 | 10.90 | 28 | 33487 | 9549 | 46642998 |
Initial insomnia | 18.07 | 10.90 | 19 | 33496 | 4433 | 46648114 |
Hypotension | 17.91 | 10.90 | 96 | 33419 | 232493 | 46420054 |
Application site pain | 17.83 | 10.90 | 18 | 33497 | 4005 | 46648542 |
Thinking abnormal | 17.69 | 10.90 | 28 | 33487 | 9786 | 46642761 |
Sensory level abnormal | 17.63 | 10.90 | 6 | 33509 | 160 | 46652387 |
Leukopenia | 17.52 | 10.90 | 14 | 33501 | 68329 | 46584218 |
Nystagmus | 17.45 | 10.90 | 21 | 33494 | 5678 | 46646869 |
Rash | 17.33 | 10.90 | 168 | 33347 | 356344 | 46296203 |
Therapeutic response changed | 16.98 | 10.90 | 9 | 33506 | 733 | 46651814 |
Cyanosis | 16.67 | 10.90 | 36 | 33479 | 15935 | 46636612 |
Bisexuality | 16.64 | 10.90 | 3 | 33512 | 3 | 46652544 |
Antiphospholipid syndrome | 16.58 | 10.90 | 12 | 33503 | 1700 | 46650847 |
Hunger | 16.56 | 10.90 | 17 | 33498 | 3858 | 46648689 |
Platelet count decreased | 16.54 | 10.90 | 29 | 33486 | 99995 | 46552552 |
Delusion | 16.27 | 10.90 | 29 | 33486 | 11159 | 46641388 |
Consciousness fluctuating | 16.13 | 10.90 | 8 | 33507 | 567 | 46651980 |
Libido decreased | 16.06 | 10.90 | 14 | 33501 | 2591 | 46649956 |
Affect lability | 16.02 | 10.90 | 24 | 33491 | 7996 | 46644551 |
Systemic lupus erythematosus | 15.91 | 10.90 | 14 | 33501 | 65166 | 46587381 |
Product complaint | 15.88 | 10.90 | 30 | 33485 | 12071 | 46640476 |
Nightmare | 15.73 | 10.90 | 36 | 33479 | 16562 | 46635985 |
Psoriasis | 15.70 | 10.90 | 20 | 33495 | 78584 | 46573963 |
Body temperature increased | 15.41 | 10.90 | 46 | 33469 | 24815 | 46627732 |
Vasospasm | 15.37 | 10.90 | 8 | 33507 | 628 | 46651919 |
Hyponatraemia | 15.33 | 10.90 | 31 | 33484 | 101301 | 46551246 |
Cough | 15.10 | 10.90 | 100 | 33415 | 230149 | 46422398 |
Substance use | 15.08 | 10.90 | 7 | 33508 | 428 | 46652119 |
Lactic acidosis | 15.07 | 10.90 | 3 | 33512 | 33906 | 46618641 |
C-reactive protein increased | 15.02 | 10.90 | 12 | 33503 | 58578 | 46593969 |
Mobility decreased | 14.81 | 10.90 | 13 | 33502 | 60581 | 46591966 |
Hepatic failure | 14.76 | 10.90 | 3 | 33512 | 33413 | 46619134 |
Raynaud's phenomenon | 14.65 | 10.90 | 10 | 33505 | 1290 | 46651257 |
Seizure like phenomena | 14.52 | 10.90 | 9 | 33506 | 986 | 46651561 |
Arthropathy | 14.51 | 10.90 | 24 | 33491 | 84676 | 46567871 |
Rhabdomyolysis | 14.42 | 10.90 | 6 | 33509 | 41903 | 46610644 |
Blister | 14.40 | 10.90 | 7 | 33508 | 44624 | 46607923 |
Mucosal inflammation | 14.38 | 10.90 | 5 | 33510 | 38971 | 46613576 |
Pyrexia | 14.28 | 10.90 | 171 | 33344 | 348631 | 46303916 |
Palpitations | 14.25 | 10.90 | 117 | 33398 | 95142 | 46557405 |
International normalised ratio increased | 14.17 | 10.90 | 8 | 33507 | 46875 | 46605672 |
Polycystic ovaries | 14.09 | 10.90 | 10 | 33505 | 1374 | 46651173 |
Decreased appetite | 14.04 | 10.90 | 206 | 33309 | 193630 | 46458917 |
Rectal haemorrhage | 13.95 | 10.90 | 5 | 33510 | 38250 | 46614297 |
Sedation | 13.83 | 10.90 | 42 | 33473 | 22868 | 46629679 |
Distractibility | 13.82 | 10.90 | 6 | 33509 | 313 | 46652234 |
Acne | 13.45 | 10.90 | 38 | 33477 | 19881 | 46632666 |
Phobia | 13.41 | 10.90 | 6 | 33509 | 337 | 46652210 |
Regressive behaviour | 13.39 | 10.90 | 4 | 33511 | 69 | 46652478 |
Illness | 13.27 | 10.90 | 28 | 33487 | 12196 | 46640351 |
Brain death | 13.19 | 10.90 | 13 | 33502 | 2810 | 46649737 |
Cleft lip and palate | 13.07 | 10.90 | 6 | 33509 | 358 | 46652189 |
Coronary artery disease | 13.03 | 10.90 | 4 | 33511 | 33748 | 46618799 |
Foot fracture | 12.87 | 10.90 | 37 | 33478 | 19545 | 46633002 |
Herpes zoster | 12.81 | 10.90 | 18 | 33497 | 67854 | 46584693 |
Formication | 12.81 | 10.90 | 15 | 33500 | 3941 | 46648606 |
Oculogyric crisis | 12.76 | 10.90 | 9 | 33506 | 1224 | 46651323 |
Gastric banding | 12.57 | 10.90 | 4 | 33511 | 86 | 46652461 |
Malignant neoplasm progression | 12.48 | 10.90 | 17 | 33498 | 64909 | 46587638 |
Abdominal discomfort | 12.41 | 10.90 | 61 | 33454 | 151104 | 46501443 |
Hangover | 12.36 | 10.90 | 9 | 33506 | 1286 | 46651261 |
Cerebral artery occlusion | 12.35 | 10.90 | 8 | 33507 | 946 | 46651601 |
Diplopia | 12.12 | 10.90 | 36 | 33479 | 19369 | 46633178 |
Acute respiratory failure | 12.10 | 10.90 | 3 | 33512 | 29135 | 46623412 |
Eating disorder | 11.96 | 10.90 | 30 | 33485 | 14624 | 46637923 |
Tongue biting | 11.94 | 10.90 | 9 | 33506 | 1355 | 46651192 |
Drug tolerance | 11.77 | 10.90 | 13 | 33502 | 3205 | 46649342 |
Grimacing | 11.77 | 10.90 | 6 | 33509 | 451 | 46652096 |
Petit mal epilepsy | 11.77 | 10.90 | 13 | 33502 | 3207 | 46649340 |
Drug abuser | 11.72 | 10.90 | 13 | 33502 | 3220 | 46649327 |
Drug intolerance | 11.70 | 10.90 | 60 | 33455 | 146989 | 46505558 |
Drug use disorder | 11.69 | 10.90 | 12 | 33503 | 2723 | 46649824 |
Hypoxia | 11.64 | 10.90 | 12 | 33503 | 51826 | 46600721 |
Femur fracture | 11.64 | 10.90 | 6 | 33509 | 36991 | 46615556 |
Mental disorder | 11.62 | 10.90 | 39 | 33476 | 22386 | 46630161 |
Schizoaffective disorder bipolar type | 11.57 | 10.90 | 4 | 33511 | 112 | 46652435 |
Horner's syndrome | 11.55 | 10.90 | 3 | 33512 | 30 | 46652517 |
Sleep disorder | 11.51 | 10.90 | 65 | 33450 | 46730 | 46605817 |
Hallucinations, mixed | 11.48 | 10.90 | 14 | 33501 | 3835 | 46648712 |
Treatment noncompliance | 11.46 | 10.90 | 47 | 33468 | 29684 | 46622863 |
Hyperacusis | 11.45 | 10.90 | 10 | 33505 | 1854 | 46650693 |
Nephrogenic diabetes insipidus | 11.38 | 10.90 | 7 | 33508 | 756 | 46651791 |
Radius fracture | 11.37 | 10.90 | 13 | 33502 | 3329 | 46649218 |
Tonic convulsion | 11.28 | 10.90 | 8 | 33507 | 1098 | 46651449 |
White blood cell count decreased | 11.23 | 10.90 | 42 | 33473 | 112189 | 46540358 |
Loss of consciousness | 11.23 | 10.90 | 123 | 33392 | 108115 | 46544432 |
Balance disorder | 11.17 | 10.90 | 82 | 33433 | 64439 | 46588108 |
Diaphragmalgia | 11.07 | 10.90 | 4 | 33511 | 128 | 46652419 |
Infected cyst | 10.97 | 10.90 | 7 | 33508 | 807 | 46651740 |
Nervousness | 10.96 | 10.90 | 45 | 33470 | 28430 | 46624117 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Product quality issue | 857.48 | 13.28 | 429 | 35732 | 18345 | 29897972 |
No adverse event | 637.06 | 13.28 | 343 | 35818 | 17076 | 29899241 |
Aggression | 614.33 | 13.28 | 440 | 35721 | 36467 | 29879850 |
Tic | 515.43 | 13.28 | 161 | 36000 | 1871 | 29914446 |
Agitation | 406.60 | 13.28 | 408 | 35753 | 53665 | 29862652 |
Abnormal behaviour | 404.43 | 13.28 | 296 | 35865 | 25327 | 29890990 |
Suicidal ideation | 336.76 | 13.28 | 307 | 35854 | 35807 | 29880510 |
Product substitution issue | 318.24 | 13.28 | 180 | 35981 | 9855 | 29906462 |
Wrong technique in product usage process | 312.49 | 13.28 | 276 | 35885 | 30879 | 29885438 |
Irritability | 305.56 | 13.28 | 240 | 35921 | 22810 | 29893507 |
Application site erythema | 301.19 | 13.28 | 111 | 36050 | 2192 | 29914125 |
Psychomotor hyperactivity | 292.22 | 13.28 | 159 | 36002 | 8065 | 29908252 |
Attention deficit hyperactivity disorder | 276.30 | 13.28 | 98 | 36063 | 1726 | 29914591 |
Growth retardation | 219.91 | 13.28 | 80 | 36081 | 1520 | 29914797 |
Psychotic disorder | 212.44 | 13.28 | 189 | 35972 | 21326 | 29894991 |
Disturbance in attention | 209.82 | 13.28 | 190 | 35971 | 21939 | 29894378 |
Dyskinesia | 204.14 | 13.28 | 186 | 35975 | 21648 | 29894669 |
Product administration error | 199.79 | 13.28 | 154 | 36007 | 14223 | 29902094 |
Product administered at inappropriate site | 196.23 | 13.28 | 74 | 36087 | 1561 | 29914756 |
Acute kidney injury | 195.01 | 13.28 | 46 | 36115 | 273796 | 29642521 |
Crying | 192.48 | 13.28 | 106 | 36055 | 5503 | 29910814 |
Anxiety | 179.94 | 13.28 | 359 | 35802 | 89512 | 29826805 |
Application site irritation | 165.98 | 13.28 | 53 | 36108 | 664 | 29915653 |
Application site pruritus | 163.82 | 13.28 | 62 | 36099 | 1321 | 29914996 |
Dystonia | 157.00 | 13.28 | 114 | 36047 | 9613 | 29906704 |
Suicide attempt | 150.65 | 13.28 | 203 | 35958 | 36494 | 29879823 |
Tachycardia | 146.84 | 13.28 | 294 | 35867 | 73445 | 29842872 |
Pneumonia | 146.65 | 13.28 | 114 | 36047 | 334192 | 29582125 |
Incorrect product administration duration | 142.55 | 13.28 | 77 | 36084 | 3845 | 29912472 |
Insomnia | 142.28 | 13.28 | 334 | 35827 | 93002 | 29823315 |
Death | 134.99 | 13.28 | 140 | 36021 | 357143 | 29559174 |
Depression | 134.98 | 13.28 | 321 | 35840 | 90116 | 29826201 |
Choreoathetosis | 132.76 | 13.28 | 48 | 36113 | 895 | 29915422 |
Educational problem | 132.31 | 13.28 | 37 | 36124 | 282 | 29916035 |
Disturbance in social behaviour | 128.80 | 13.28 | 53 | 36108 | 1418 | 29914899 |
Impulsive behaviour | 126.63 | 13.28 | 57 | 36104 | 1908 | 29914409 |
Anger | 126.57 | 13.28 | 106 | 36055 | 11014 | 29905303 |
Intentional product misuse | 124.70 | 13.28 | 180 | 35981 | 34487 | 29881830 |
Drug ineffective | 116.84 | 13.28 | 755 | 35406 | 339632 | 29576685 |
Hallucination, visual | 105.39 | 13.28 | 113 | 36048 | 16000 | 29900317 |
Anaemia | 104.29 | 13.28 | 61 | 36100 | 207931 | 29708386 |
Intentional overdose | 101.88 | 13.28 | 181 | 35980 | 41300 | 29875017 |
Withdrawal syndrome | 97.67 | 13.28 | 92 | 36069 | 11158 | 29905159 |
Trismus | 96.03 | 13.28 | 50 | 36111 | 2315 | 29914002 |
Mydriasis | 94.61 | 13.28 | 70 | 36091 | 6073 | 29910244 |
Oppositional defiant disorder | 94.22 | 13.28 | 30 | 36131 | 372 | 29915945 |
Priapism | 91.46 | 13.28 | 62 | 36099 | 4681 | 29911636 |
Palpitations | 89.62 | 13.28 | 152 | 36009 | 33421 | 29882896 |
Coronary artery dissection | 89.40 | 13.28 | 24 | 36137 | 154 | 29916163 |
Drug diversion | 87.04 | 13.28 | 35 | 36126 | 881 | 29915436 |
Product prescribing error | 86.72 | 13.28 | 104 | 36057 | 16629 | 29899688 |
Drug dependence | 86.12 | 13.28 | 117 | 36044 | 21178 | 29895139 |
Product complaint | 84.60 | 13.28 | 64 | 36097 | 5742 | 29910575 |
Diarrhoea | 83.80 | 13.28 | 174 | 35987 | 333929 | 29582388 |
Hallucination, auditory | 82.97 | 13.28 | 79 | 36082 | 9710 | 29906607 |
Emotional disorder | 82.87 | 13.28 | 60 | 36101 | 5034 | 29911283 |
Therapeutic product effect decreased | 82.09 | 13.28 | 135 | 36026 | 28941 | 29887376 |
Hallucination, tactile | 81.81 | 13.28 | 25 | 36136 | 268 | 29916049 |
Hypotension | 80.81 | 13.28 | 74 | 36087 | 200491 | 29715826 |
Somnolence | 79.33 | 13.28 | 277 | 35884 | 96486 | 29819831 |
Depressed mood | 78.83 | 13.28 | 100 | 36061 | 16929 | 29899388 |
Overdose | 78.50 | 13.28 | 252 | 35909 | 84085 | 29832232 |
Hallucination | 78.40 | 13.28 | 179 | 35982 | 48880 | 29867437 |
Homicidal ideation | 77.55 | 13.28 | 44 | 36117 | 2419 | 29913898 |
Bruxism | 76.84 | 13.28 | 36 | 36125 | 1323 | 29914994 |
Dyspnoea | 76.66 | 13.28 | 182 | 35979 | 333113 | 29583204 |
Sleep disorder | 76.42 | 13.28 | 119 | 36042 | 24360 | 29891957 |
Precocious puberty | 75.96 | 13.28 | 19 | 36142 | 88 | 29916229 |
Sepsis | 74.64 | 13.28 | 42 | 36119 | 146353 | 29769964 |
Trichotillomania | 73.75 | 13.28 | 17 | 36144 | 51 | 29916266 |
Restlessness | 70.74 | 13.28 | 110 | 36051 | 22489 | 29893828 |
Application site rash | 69.64 | 13.28 | 29 | 36132 | 800 | 29915517 |
Renal failure | 68.66 | 13.28 | 35 | 36126 | 128931 | 29787386 |
Febrile neutropenia | 68.09 | 13.28 | 22 | 36139 | 106671 | 29809646 |
Gastrointestinal haemorrhage | 67.76 | 13.28 | 10 | 36151 | 83436 | 29832881 |
Logorrhoea | 67.74 | 13.28 | 38 | 36123 | 2044 | 29914273 |
Paranoia | 67.58 | 13.28 | 72 | 36089 | 10116 | 29906201 |
Mood altered | 66.93 | 13.28 | 65 | 36096 | 8185 | 29908132 |
Mania | 64.84 | 13.28 | 67 | 36094 | 9087 | 29907230 |
Decreased eye contact | 64.46 | 13.28 | 23 | 36138 | 412 | 29915905 |
Cardiac failure congestive | 62.24 | 13.28 | 13 | 36148 | 84394 | 29831923 |
Affect lability | 61.93 | 13.28 | 43 | 36118 | 3375 | 29912942 |
Serotonin syndrome | 61.54 | 13.28 | 91 | 36070 | 17800 | 29898517 |
Intentional self-injury | 60.33 | 13.28 | 78 | 36083 | 13454 | 29902863 |
Haemoglobin decreased | 59.19 | 13.28 | 32 | 36129 | 114066 | 29802251 |
Toxicity to various agents | 59.18 | 13.28 | 391 | 35770 | 176792 | 29739525 |
Drug use disorder | 59.17 | 13.28 | 41 | 36120 | 3207 | 29913110 |
Euphoric mood | 57.49 | 13.28 | 45 | 36116 | 4245 | 29912072 |
Decreased appetite | 57.00 | 13.28 | 342 | 35819 | 149568 | 29766749 |
Obsessive-compulsive disorder | 56.72 | 13.28 | 44 | 36117 | 4097 | 29912220 |
Renal impairment | 56.16 | 13.28 | 16 | 36145 | 84168 | 29832149 |
Apathy | 56.08 | 13.28 | 52 | 36109 | 6180 | 29910137 |
Headache | 55.94 | 13.28 | 394 | 35767 | 181912 | 29734405 |
Application site pain | 55.87 | 13.28 | 31 | 36130 | 1632 | 29914685 |
Product administered to patient of inappropriate age | 55.71 | 13.28 | 36 | 36125 | 2507 | 29913810 |
Feeling abnormal | 54.97 | 13.28 | 172 | 35989 | 56584 | 29859733 |
Interstitial lung disease | 54.36 | 13.28 | 5 | 36156 | 60192 | 29856125 |
Pyrexia | 54.13 | 13.28 | 179 | 35982 | 294310 | 29622007 |
General physical health deterioration | 53.36 | 13.28 | 27 | 36134 | 99917 | 29816400 |
Speech disorder | 52.65 | 13.28 | 101 | 36060 | 24411 | 29891906 |
Thrombocytopenia | 51.16 | 13.28 | 54 | 36107 | 136990 | 29779327 |
Autism spectrum disorder | 50.91 | 13.28 | 27 | 36134 | 1298 | 29915019 |
Multiple organ dysfunction syndrome | 50.63 | 13.28 | 8 | 36153 | 63479 | 29852838 |
Pancytopenia | 48.45 | 13.28 | 21 | 36140 | 85031 | 29831286 |
Social avoidant behaviour | 47.20 | 13.28 | 34 | 36127 | 2829 | 29913488 |
Formication | 46.97 | 13.28 | 28 | 36133 | 1689 | 29914628 |
Blood creatinine increased | 46.84 | 13.28 | 26 | 36135 | 91349 | 29824968 |
Enuresis | 46.13 | 13.28 | 28 | 36133 | 1746 | 29914571 |
Application site urticaria | 45.97 | 13.28 | 12 | 36149 | 68 | 29916249 |
Platelet count decreased | 45.29 | 13.28 | 37 | 36124 | 106092 | 29810225 |
Gynaecomastia | 45.06 | 13.28 | 53 | 36108 | 8298 | 29908019 |
Oromandibular dystonia | 44.99 | 13.28 | 18 | 36143 | 447 | 29915870 |
Keratoconus | 44.70 | 13.28 | 11 | 36150 | 47 | 29916270 |
Torticollis | 44.43 | 13.28 | 23 | 36138 | 1052 | 29915265 |
Product taste abnormal | 43.58 | 13.28 | 23 | 36138 | 1095 | 29915222 |
Respiratory failure | 43.05 | 13.28 | 35 | 36126 | 100607 | 29815710 |
Therapeutic response unexpected | 42.34 | 13.28 | 53 | 36108 | 8850 | 29907467 |
Product use issue | 42.31 | 13.28 | 137 | 36024 | 45879 | 29870438 |
Alice in wonderland syndrome | 41.96 | 13.28 | 9 | 36152 | 17 | 29916300 |
Hyperkalaemia | 41.41 | 13.28 | 14 | 36147 | 65996 | 29850321 |
Drug abuse | 41.12 | 13.28 | 202 | 35959 | 81870 | 29834447 |
Mood swings | 40.49 | 13.28 | 48 | 36113 | 7578 | 29908739 |
Neutropenia | 40.23 | 13.28 | 58 | 36103 | 128482 | 29787835 |
Dermatillomania | 40.10 | 13.28 | 9 | 36152 | 23 | 29916294 |
Raynaud's phenomenon | 40.10 | 13.28 | 15 | 36146 | 309 | 29916008 |
Hallucinations, mixed | 39.82 | 13.28 | 29 | 36132 | 2454 | 29913863 |
Increased appetite | 39.57 | 13.28 | 41 | 36120 | 5576 | 29910741 |
Drug screen negative | 39.28 | 13.28 | 14 | 36147 | 250 | 29916067 |
Extrapyramidal disorder | 37.65 | 13.28 | 55 | 36106 | 10638 | 29905679 |
Cardiac failure | 36.94 | 13.28 | 28 | 36133 | 83390 | 29832927 |
Excessive eye blinking | 36.17 | 13.28 | 13 | 36148 | 238 | 29916079 |
Product colour issue | 35.61 | 13.28 | 15 | 36146 | 426 | 29915891 |
Product adhesion issue | 35.23 | 13.28 | 22 | 36139 | 1443 | 29914874 |
Oedema peripheral | 34.87 | 13.28 | 46 | 36115 | 105786 | 29810531 |
Atrial fibrillation | 34.61 | 13.28 | 48 | 36113 | 108076 | 29808241 |
Heart rate increased | 34.44 | 13.28 | 114 | 36047 | 38607 | 29877710 |
Off label use | 34.35 | 13.28 | 455 | 35706 | 248835 | 29667482 |
Ventricular parasystole | 34.32 | 13.28 | 6 | 36155 | 0 | 29916317 |
Onychophagia | 34.22 | 13.28 | 8 | 36153 | 26 | 29916291 |
Suicidal behaviour | 34.14 | 13.28 | 21 | 36140 | 1341 | 29914976 |
Phobia | 34.00 | 13.28 | 10 | 36151 | 93 | 29916224 |
Incorrect dose administered | 33.44 | 13.28 | 99 | 36062 | 31587 | 29884730 |
Generalised tonic-clonic seizure | 33.06 | 13.28 | 73 | 36088 | 19478 | 29896839 |
Septic shock | 32.73 | 13.28 | 18 | 36143 | 63589 | 29852728 |
White blood cell count decreased | 32.52 | 13.28 | 32 | 36129 | 83915 | 29832402 |
Hypertension | 32.43 | 13.28 | 254 | 35907 | 121100 | 29795217 |
Plasma cell myeloma | 32.39 | 13.28 | 12 | 36149 | 53450 | 29862867 |
Coordination abnormal | 32.39 | 13.28 | 42 | 36119 | 7263 | 29909054 |
Muscle contracture | 32.23 | 13.28 | 19 | 36142 | 1123 | 29915194 |
Screaming | 32.04 | 13.28 | 20 | 36141 | 1311 | 29915006 |
Affective disorder | 32.04 | 13.28 | 28 | 36133 | 3080 | 29913237 |
Sleep apnoea syndrome | 32.03 | 13.28 | 66 | 36095 | 16791 | 29899526 |
Drug tolerance | 31.86 | 13.28 | 24 | 36137 | 2138 | 29914179 |
Treatment noncompliance | 31.66 | 13.28 | 84 | 36077 | 25169 | 29891148 |
Rheumatoid arthritis | 31.07 | 13.28 | 6 | 36155 | 41191 | 29875126 |
Tourette's disorder | 30.96 | 13.28 | 9 | 36152 | 80 | 29916237 |
Asthenia | 30.19 | 13.28 | 151 | 36010 | 221139 | 29695178 |
Peripheral coldness | 29.42 | 13.28 | 38 | 36123 | 6545 | 29909772 |
Bipolar disorder | 29.23 | 13.28 | 29 | 36132 | 3747 | 29912570 |
Rebound effect | 29.13 | 13.28 | 20 | 36141 | 1541 | 29914776 |
Peripheral swelling | 29.01 | 13.28 | 19 | 36142 | 61055 | 29855262 |
Tardive dyskinesia | 28.80 | 13.28 | 33 | 36128 | 5024 | 29911293 |
Tremor | 28.61 | 13.28 | 172 | 35989 | 75191 | 29841126 |
Sympathomimetic effect | 28.60 | 13.28 | 5 | 36156 | 0 | 29916317 |
Hyperkinesia | 28.10 | 13.28 | 22 | 36139 | 2076 | 29914241 |
Gilbert's syndrome | 27.88 | 13.28 | 7 | 36154 | 33 | 29916284 |
Delusion | 27.73 | 13.28 | 51 | 36110 | 11938 | 29904379 |
Joint swelling | 27.67 | 13.28 | 11 | 36150 | 46935 | 29869382 |
Arthralgia | 27.37 | 13.28 | 79 | 36082 | 135712 | 29780605 |
Metabolic acidosis | 27.13 | 13.28 | 6 | 36155 | 37455 | 29878862 |
Nervousness | 27.08 | 13.28 | 50 | 36111 | 11738 | 29904579 |
Cough | 26.88 | 13.28 | 71 | 36090 | 125571 | 29790746 |
Pain | 26.37 | 13.28 | 113 | 36048 | 172528 | 29743789 |
Application site erosion | 26.24 | 13.28 | 8 | 36153 | 85 | 29916232 |
Melaena | 26.05 | 13.28 | 4 | 36157 | 32433 | 29883884 |
Chronic kidney disease | 25.57 | 13.28 | 7 | 36154 | 37831 | 29878486 |
Dysphemia | 25.36 | 13.28 | 18 | 36143 | 1463 | 29914854 |
International normalised ratio increased | 25.30 | 13.28 | 13 | 36148 | 47726 | 29868591 |
Change in sustained attention | 25.14 | 13.28 | 5 | 36156 | 5 | 29916312 |
Completed suicide | 24.80 | 13.28 | 205 | 35956 | 99287 | 29817030 |
Mental disorder | 24.78 | 13.28 | 52 | 36109 | 13397 | 29902920 |
Delayed puberty | 24.78 | 13.28 | 9 | 36152 | 170 | 29916147 |
Infection | 24.63 | 13.28 | 35 | 36126 | 78039 | 29838278 |
Cataplexy | 24.61 | 13.28 | 11 | 36150 | 362 | 29915955 |
Polydipsia psychogenic | 24.17 | 13.28 | 8 | 36153 | 113 | 29916204 |
Cerebral congestion | 24.13 | 13.28 | 6 | 36155 | 27 | 29916290 |
Multiple cardiac defects | 23.62 | 13.28 | 7 | 36154 | 67 | 29916250 |
Somnambulism | 23.62 | 13.28 | 24 | 36137 | 3190 | 29913127 |
Pleural effusion | 23.57 | 13.28 | 33 | 36128 | 74033 | 29842284 |
Hyperhidrosis | 23.50 | 13.28 | 150 | 36011 | 66940 | 29849377 |
Product dispensing error | 23.26 | 13.28 | 32 | 36129 | 5857 | 29910460 |
Fall | 23.16 | 13.28 | 127 | 36034 | 181745 | 29734572 |
Weight gain poor | 23.02 | 13.28 | 14 | 36147 | 876 | 29915441 |
Coronary artery disease | 22.89 | 13.28 | 16 | 36145 | 49696 | 29866621 |
Distractibility | 22.78 | 13.28 | 10 | 36151 | 315 | 29916002 |
Blood urea increased | 22.78 | 13.28 | 5 | 36156 | 31376 | 29884941 |
Oxygen saturation decreased | 22.77 | 13.28 | 12 | 36149 | 43428 | 29872889 |
Illusion | 22.26 | 13.28 | 13 | 36148 | 755 | 29915562 |
Erythema | 22.25 | 13.28 | 37 | 36124 | 77414 | 29838903 |
Malignant neoplasm progression | 22.22 | 13.28 | 33 | 36128 | 72254 | 29844063 |
Colitis | 22.19 | 13.28 | 5 | 36156 | 30815 | 29885502 |
Dehydration | 21.98 | 13.28 | 76 | 36085 | 123463 | 29792854 |
Drug withdrawal syndrome | 21.96 | 13.28 | 63 | 36098 | 19746 | 29896571 |
Tongue spasm | 21.90 | 13.28 | 6 | 36155 | 42 | 29916275 |
Self-injurious ideation | 21.82 | 13.28 | 17 | 36144 | 1592 | 29914725 |
Infusion related reaction | 21.57 | 13.28 | 11 | 36150 | 40553 | 29875764 |
Panic attack | 21.44 | 13.28 | 38 | 36123 | 8643 | 29907674 |
Hyponatraemia | 21.32 | 13.28 | 30 | 36131 | 67172 | 29849145 |
Liver disorder | 21.04 | 13.28 | 5 | 36156 | 29717 | 29886600 |
School refusal | 21.00 | 13.28 | 5 | 36156 | 18 | 29916299 |
Sudden death | 20.92 | 13.28 | 53 | 36108 | 15439 | 29900878 |
Application site dryness | 20.88 | 13.28 | 6 | 36155 | 51 | 29916266 |
Substance abuse | 20.27 | 13.28 | 33 | 36128 | 7007 | 29909310 |
Petit mal epilepsy | 19.98 | 13.28 | 20 | 36141 | 2611 | 29913706 |
Seizure | 19.96 | 13.28 | 194 | 35967 | 98281 | 29818036 |
Neuropathy peripheral | 19.93 | 13.28 | 34 | 36127 | 70441 | 29845876 |
Application site scab | 19.83 | 13.28 | 6 | 36155 | 62 | 29916255 |
Strabismus | 19.72 | 13.28 | 14 | 36147 | 1138 | 29915179 |
Performance status decreased | 19.52 | 13.28 | 24 | 36137 | 3933 | 29912384 |
Drooling | 19.51 | 13.28 | 21 | 36140 | 2984 | 29913333 |
Pain in extremity | 19.48 | 13.28 | 68 | 36093 | 110153 | 29806164 |
Abdominal distension | 19.40 | 13.28 | 16 | 36145 | 45693 | 29870624 |
Regressive behaviour | 19.35 | 13.28 | 5 | 36156 | 27 | 29916290 |
Scoliosis | 19.31 | 13.28 | 16 | 36145 | 1636 | 29914681 |
Myocardial infarction | 19.31 | 13.28 | 82 | 36079 | 125543 | 29790774 |
Muscle twitching | 19.25 | 13.28 | 35 | 36126 | 8120 | 29908197 |
Panic reaction | 19.22 | 13.28 | 15 | 36146 | 1408 | 29914909 |
Incorrect route of product administration | 18.85 | 13.28 | 42 | 36119 | 11273 | 29905044 |
Disease progression | 18.74 | 13.28 | 43 | 36118 | 79831 | 29836486 |
Migraine | 18.39 | 13.28 | 45 | 36116 | 12829 | 29903488 |
Chorea | 18.08 | 13.28 | 13 | 36148 | 1078 | 29915239 |
Cholestasis | 18.06 | 13.28 | 4 | 36157 | 24946 | 29891371 |
Suspiciousness | 18.05 | 13.28 | 9 | 36152 | 380 | 29915937 |
Negativism | 18.03 | 13.28 | 9 | 36152 | 381 | 29915936 |
Drug reaction with eosinophilia and systemic symptoms | 17.93 | 13.28 | 6 | 36155 | 28482 | 29887835 |
Product dose omission issue | 17.83 | 13.28 | 179 | 35982 | 91452 | 29824865 |
Insulin resistance | 17.58 | 13.28 | 10 | 36151 | 552 | 29915765 |
C-reactive protein increased | 17.50 | 13.28 | 16 | 36145 | 43457 | 29872860 |
Hepatic function abnormal | 17.41 | 13.28 | 15 | 36146 | 41930 | 29874387 |
Accidental exposure to product | 17.36 | 13.28 | 38 | 36123 | 10077 | 29906240 |
Erection increased | 17.36 | 13.28 | 10 | 36151 | 566 | 29915751 |
Idiopathic intracranial hypertension | 17.32 | 13.28 | 10 | 36151 | 568 | 29915749 |
Parasomnia | 17.28 | 13.28 | 8 | 36153 | 286 | 29916031 |
Encopresis | 17.25 | 13.28 | 5 | 36156 | 44 | 29916273 |
Blood creatine phosphokinase increased | 17.22 | 13.28 | 101 | 36060 | 43747 | 29872570 |
Limb girth decreased | 17.16 | 13.28 | 3 | 36158 | 0 | 29916317 |
Adhesive tape use | 17.16 | 13.28 | 3 | 36158 | 0 | 29916317 |
Cardiac contusion | 17.16 | 13.28 | 3 | 36158 | 0 | 29916317 |
Psychopathic personality | 17.16 | 13.28 | 3 | 36158 | 0 | 29916317 |
Testicular failure | 17.15 | 13.28 | 5 | 36156 | 45 | 29916272 |
Poor quality product administered | 17.13 | 13.28 | 15 | 36146 | 1654 | 29914663 |
Haematoma | 17.01 | 13.28 | 4 | 36157 | 23949 | 29892368 |
Accommodation disorder | 16.98 | 13.28 | 7 | 36154 | 188 | 29916129 |
Dermo-hypodermitis | 16.97 | 13.28 | 8 | 36153 | 298 | 29916019 |
Device difficult to use | 16.93 | 13.28 | 10 | 36151 | 593 | 29915724 |
Pneumonitis | 16.90 | 13.28 | 6 | 36155 | 27448 | 29888869 |
Weight increased | 16.89 | 13.28 | 151 | 36010 | 74762 | 29841555 |
Frustration tolerance decreased | 16.88 | 13.28 | 16 | 36145 | 1954 | 29914363 |
Blood thyroid stimulating hormone increased | 16.88 | 13.28 | 19 | 36142 | 2837 | 29913480 |
Vision blurred | 16.86 | 13.28 | 97 | 36064 | 41719 | 29874598 |
Physical assault | 16.85 | 13.28 | 13 | 36148 | 1200 | 29915117 |
Wolff-Parkinson-White syndrome | 16.68 | 13.28 | 7 | 36154 | 197 | 29916120 |
Pre-existing condition improved | 16.67 | 13.28 | 16 | 36145 | 1985 | 29914332 |
Neutrophil count decreased | 16.64 | 13.28 | 16 | 36145 | 42438 | 29873879 |
Mucosal inflammation | 16.62 | 13.28 | 8 | 36153 | 30486 | 29885831 |
Rash | 16.56 | 13.28 | 150 | 36011 | 191739 | 29724578 |
Constipation | 16.55 | 13.28 | 75 | 36086 | 112831 | 29803486 |
Hypocalcaemia | 16.36 | 13.28 | 3 | 36158 | 21373 | 29894944 |
Chronic obstructive pulmonary disease | 16.28 | 13.28 | 19 | 36142 | 46107 | 29870210 |
Application site ulcer | 16.27 | 13.28 | 4 | 36157 | 17 | 29916300 |
Libido increased | 16.19 | 13.28 | 11 | 36150 | 833 | 29915484 |
Sedation | 16.18 | 13.28 | 50 | 36111 | 16323 | 29899994 |
Lower respiratory tract infection | 16.17 | 13.28 | 6 | 36155 | 26708 | 29889609 |
Pericardial effusion | 16.11 | 13.28 | 3 | 36158 | 21141 | 29895176 |
Stress cardiomyopathy | 16.06 | 13.28 | 14 | 36147 | 1535 | 29914782 |
Application site discolouration | 15.99 | 13.28 | 7 | 36154 | 219 | 29916098 |
Ascites | 15.96 | 13.28 | 12 | 36149 | 35909 | 29880408 |
Bone marrow failure | 15.95 | 13.28 | 8 | 36153 | 29777 | 29886540 |
Accidental exposure to product by child | 15.95 | 13.28 | 14 | 36147 | 1549 | 29914768 |
Sydenham's chorea | 15.91 | 13.28 | 4 | 36157 | 19 | 29916298 |
Vasospasm | 15.84 | 13.28 | 8 | 36153 | 347 | 29915970 |
Acute psychosis | 15.63 | 13.28 | 15 | 36146 | 1861 | 29914456 |
Oculogyric crisis | 15.42 | 13.28 | 13 | 36148 | 1362 | 29914955 |
Hypokalaemia | 15.34 | 13.28 | 23 | 36138 | 50169 | 29866148 |
Disinhibition | 15.09 | 13.28 | 15 | 36146 | 1942 | 29914375 |
Anorexia nervosa | 15.09 | 13.28 | 3 | 36158 | 3 | 29916314 |
Drug resistance | 15.04 | 13.28 | 3 | 36158 | 20130 | 29896187 |
Opisthotonus | 14.98 | 13.28 | 8 | 36153 | 390 | 29915927 |
Hypoglycaemia | 14.97 | 13.28 | 24 | 36137 | 50957 | 29865360 |
Hepatocellular injury | 14.95 | 13.28 | 6 | 36155 | 25465 | 29890852 |
Blood growth hormone decreased | 14.85 | 13.28 | 4 | 36157 | 26 | 29916291 |
Eye movement disorder | 14.83 | 13.28 | 21 | 36140 | 3947 | 29912370 |
Meningitis staphylococcal | 14.77 | 13.28 | 5 | 36156 | 76 | 29916241 |
Urinary tract infection | 14.71 | 13.28 | 43 | 36118 | 73616 | 29842701 |
Social anxiety disorder | 14.67 | 13.28 | 7 | 36154 | 268 | 29916049 |
Acute respiratory distress syndrome | 14.67 | 13.28 | 5 | 36156 | 23467 | 29892850 |
Inappropriate affect | 14.66 | 13.28 | 9 | 36152 | 573 | 29915744 |
Productive cough | 14.66 | 13.28 | 9 | 36152 | 29944 | 29886373 |
Hypoxia | 14.55 | 13.28 | 22 | 36139 | 47832 | 29868485 |
Poor quality sleep | 14.52 | 13.28 | 29 | 36132 | 7212 | 29909105 |
Prescribed overdose | 14.51 | 13.28 | 32 | 36129 | 8529 | 29907788 |
Psoriasis | 14.47 | 13.28 | 18 | 36143 | 42488 | 29873829 |
Amnesia | 14.47 | 13.28 | 63 | 36098 | 24258 | 29892059 |
Product residue present | 14.45 | 13.28 | 17 | 36144 | 2661 | 29913656 |
Hyperacusis | 14.32 | 13.28 | 9 | 36152 | 597 | 29915720 |
Thrombosis | 14.26 | 13.28 | 18 | 36143 | 42213 | 29874104 |
Stubbornness | 14.24 | 13.28 | 4 | 36157 | 31 | 29916286 |
Ataxia | 14.23 | 13.28 | 38 | 36123 | 11424 | 29904893 |
Epiphyses delayed fusion | 14.23 | 13.28 | 3 | 36158 | 5 | 29916312 |
Pressure of speech | 14.20 | 13.28 | 8 | 36153 | 434 | 29915883 |
Gastrooesophageal reflux disease | 14.05 | 13.28 | 11 | 36150 | 32244 | 29884073 |
Defect conduction intraventricular | 14 | 13.28 | 6 | 36155 | 178 | 29916139 |
Nightmare | 13.96 | 13.28 | 39 | 36122 | 12037 | 29904280 |
Reading disorder | 13.94 | 13.28 | 7 | 36154 | 300 | 29916017 |
Pulmonary embolism | 13.93 | 13.28 | 48 | 36113 | 78087 | 29838230 |
Dysphoria | 13.92 | 13.28 | 15 | 36146 | 2133 | 29914184 |
Electrocardiogram T wave inversion | 13.89 | 13.28 | 15 | 36146 | 2139 | 29914178 |
Schizotypal personality disorder | 13.87 | 13.28 | 3 | 36158 | 6 | 29916311 |
Personality change | 13.84 | 13.28 | 22 | 36139 | 4578 | 29911739 |
Narcolepsy | 13.83 | 13.28 | 8 | 36153 | 456 | 29915861 |
Compulsions | 13.75 | 13.28 | 6 | 36155 | 186 | 29916131 |
Stomatitis | 13.54 | 13.28 | 15 | 36146 | 37264 | 29879053 |
Therapeutic product effect delayed | 13.51 | 13.28 | 11 | 36150 | 1098 | 29915219 |
Osteonecrosis of jaw | 13.44 | 13.28 | 3 | 36158 | 18615 | 29897702 |
Substance-induced psychotic disorder | 13.42 | 13.28 | 12 | 36149 | 1360 | 29914957 |
Urinary incontinence | 13.41 | 13.28 | 48 | 36113 | 16892 | 29899425 |
Lung disorder | 13.37 | 13.28 | 11 | 36150 | 31458 | 29884859 |
Therapeutic product effect increased | 13.35 | 13.28 | 9 | 36152 | 673 | 29915644 |
Source | Code | Description |
---|---|---|
ATC | N06BA04 | NERVOUS SYSTEM PSYCHOANALEPTICS PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS Centrally acting sympathomimetics |
FDA PE | N0000175729 | Central Nervous System Stimulation |
FDA EPC | N0000175739 | Central Nervous System Stimulant |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D000697 | Central Nervous System Stimulants |
MeSH PA | D015259 | Dopamine Agents |
MeSH PA | D018765 | Dopamine Uptake Inhibitors |
MeSH PA | D049990 | Membrane Transport Modulators |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D014179 | Neurotransmitter Uptake Inhibitors |
CHEBI has role | CHEBI:35337 | analeptic drug |
CHEBI has role | CHEBI:35471 | psychopharmaceuticals |
CHEBI has role | CHEBI:35524 | sympathomimetic |
CHEBI has role | CHEBI:35640 | adrenergic uptake inhibitors |
CHEBI has role | CHEBI:37962 | adrenergic neuron agents |
CHEBI has role | CHEBI:51039 | dopamine reuptake inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Narcolepsy | indication | 60380001 | DOID:8986 |
Attention deficit hyperactivity disorder | indication | 406506008 | |
Depressive disorder | off-label use | 35489007 | |
Cognitive Impairment following Traumatic Brain Injury | off-label use | ||
Gilles de la Tourette's syndrome | contraindication | 5158005 | DOID:11119 |
Dependent drug abuse | contraindication | 6525002 | |
Alcoholism | contraindication | 7200002 | |
Sinus tachycardia | contraindication | 11092001 | |
Bipolar disorder | contraindication | 13746004 | DOID:3312 |
Mood swings | contraindication | 18963009 | |
Lowered convulsive threshold | contraindication | 19260006 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Feeling agitated | contraindication | 24199005 | |
Short bowel syndrome | contraindication | 26629001 | DOID:10605 |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Conduction disorder of the heart | contraindication | 44808001 | |
Chronic heart failure | contraindication | 48447003 | |
Tension | contraindication | 53489000 | |
Anorexia nervosa | contraindication | 56882008 | DOID:8689 |
Aggressive behavior | contraindication | 61372001 | |
Substance abuse | contraindication | 66214007 | |
Psychotic disorder | contraindication | 69322001 | |
Severe anxiety (panic) | contraindication | 80583007 | |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Leukopenia | contraindication | 84828003 | DOID:615 |
Cardiomyopathy | contraindication | 85898001 | DOID:0050700 |
Thyrotoxicosis | contraindication | 90739004 | DOID:7997 |
Blurring of visual image | contraindication | 111516008 | |
Gastrointestinal obstruction | contraindication | 126765001 | |
Structural disorder of heart | contraindication | 128599005 | |
Seizure disorder | contraindication | 128613002 | |
Liver function tests abnormal | contraindication | 166603001 | |
Angina pectoris | contraindication | 194828000 | |
Motor tic disorder | contraindication | 230337001 | |
Cerebrovascular accident | contraindication | 230690007 | |
Mania | contraindication | 231494001 | |
Esophageal dysmotility | contraindication | 266434009 | DOID:9192 |
Anemia | contraindication | 271737000 | DOID:2355 |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Visual impairment | contraindication | 397540003 | |
Disorder of coronary artery | contraindication | 414024009 | |
Myocardial infarction in recovery phase | contraindication | 418044006 | |
Hypertensive urgency | contraindication | 443482000 | |
Life-Threatening Cardiac Arrhythmias | contraindication | ||
Uncontrolled Epilepsy | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.68 | Basic |
None
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
100MG | JORNULLY PM | IRONSHORE PHARMS | N209311 | Aug. 8, 2018 | RX | CAPSULE, EXTENDED RELEASE | ORAL | Aug. 8, 2021 | NEW PRODUCT |
20MG | JORNULLY PM | IRONSHORE PHARMS | N209311 | Aug. 8, 2018 | RX | CAPSULE, EXTENDED RELEASE | ORAL | Aug. 8, 2021 | NEW PRODUCT |
40MG | JORNULLY PM | IRONSHORE PHARMS | N209311 | Aug. 8, 2018 | RX | CAPSULE, EXTENDED RELEASE | ORAL | Aug. 8, 2021 | NEW PRODUCT |
60MG | JORNULLY PM | IRONSHORE PHARMS | N209311 | Aug. 8, 2018 | RX | CAPSULE, EXTENDED RELEASE | ORAL | Aug. 8, 2021 | NEW PRODUCT |
80MG | JORNULLY PM | IRONSHORE PHARMS | N209311 | Aug. 8, 2018 | RX | CAPSULE, EXTENDED RELEASE | ORAL | Aug. 8, 2021 | NEW PRODUCT |
25MG | ADHANSIA XR | PURDUE PHARMA LP | N212038 | Feb. 27, 2019 | RX | CAPSULE, EXTENDED RELEASE | ORAL | Feb. 27, 2022 | NEW PRODUCT |
35MG | ADHANSIA XR | PURDUE PHARMA LP | N212038 | Feb. 27, 2019 | RX | CAPSULE, EXTENDED RELEASE | ORAL | Feb. 27, 2022 | NEW PRODUCT |
45MG | ADHANSIA XR | PURDUE PHARMA LP | N212038 | Feb. 27, 2019 | RX | CAPSULE, EXTENDED RELEASE | ORAL | Feb. 27, 2022 | NEW PRODUCT |
55MG | ADHANSIA XR | PURDUE PHARMA LP | N212038 | Feb. 27, 2019 | RX | CAPSULE, EXTENDED RELEASE | ORAL | Feb. 27, 2022 | NEW PRODUCT |
70MG | ADHANSIA XR | PURDUE PHARMA LP | N212038 | Feb. 27, 2019 | RX | CAPSULE, EXTENDED RELEASE | ORAL | Feb. 27, 2022 | NEW PRODUCT |
85MG | ADHANSIA XR | PURDUE PHARMA LP | N212038 | Feb. 27, 2019 | RX | CAPSULE, EXTENDED RELEASE | ORAL | Feb. 27, 2022 | NEW PRODUCT |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium-dependent noradrenaline transporter | Transporter | INHIBITOR | Ki | 6.18 | CHEMBL | CHEMBL | |||
Sodium-dependent dopamine transporter | Transporter | INHIBITOR | Ki | 6.96 | CHEMBL | CHEMBL | |||
Alpha-2A adrenergic receptor | GPCR | Ki | 5.25 | PDSP | |||||
Alpha-2C adrenergic receptor | GPCR | Ki | 6.07 | PDSP | |||||
Sodium-dependent serotonin transporter | Transporter | Ki | 4.19 | CHEMBL | |||||
Alpha-2B adrenergic receptor | GPCR | Ki | 5.61 | PDSP | |||||
Sodium-dependent dopamine transporter | Transporter | IC50 | 7.08 | CHEMBL |
ID | Source |
---|---|
4019832 | VUID |
N0000147920 | NUI |
D01296 | KEGG_DRUG |
20748-11-2 | SECONDARY_CAS_RN |
4018198 | VANDF |
4019832 | VANDF |
C0939301 | UMLSCUI |
CHEBI:31836 | CHEBI |
CHEMBL796 | ChEMBL_ID |
CHEMBL1722 | ChEMBL_ID |
D008774 | MESH_DESCRIPTOR_UI |
DB00422 | DRUGBANK_ID |
4158 | PUBCHEM_CID |
7236 | IUPHAR_LIGAND_ID |
485 | INN_ID |
207ZZ9QZ49 | UNII |
203188 | RXNORM |
1038 | MMSL |
32827 | MMSL |
37867 | MMSL |
5092 | MMSL |
d00900 | MMSL |
001540 | NDDF |
004619 | NDDF |
18548003 | SNOMEDCT_US |
373337007 | SNOMEDCT_US |
42163009 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Ritalin LA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0370 | CAPSULE, EXTENDED RELEASE | 20 mg | ORAL | NDA | 31 sections |
Ritalin LA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0371 | CAPSULE, EXTENDED RELEASE | 30 mg | ORAL | NDA | 31 sections |
Ritalin LA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0372 | CAPSULE, EXTENDED RELEASE | 40 mg | ORAL | NDA | 31 sections |
Ritalin LA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0424 | CAPSULE, EXTENDED RELEASE | 10 mg | ORAL | NDA | 31 sections |
Ritalin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0439 | TABLET | 5 mg | ORAL | NDA | 30 sections |
Ritalin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0440 | TABLET | 10 mg | ORAL | NDA | 30 sections |
Ritalin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0441 | TABLET | 20 mg | ORAL | NDA | 30 sections |
Methylphenidate Hydrochloride(CD) | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5292 | CAPSULE, EXTENDED RELEASE | 50 mg | ORAL | ANDA | 26 sections |
Methylphenidate Hydrochloride(CD) | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5293 | CAPSULE, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 26 sections |
Methylphenidate Hydrochloride(CD) | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5295 | CAPSULE, EXTENDED RELEASE | 10 mg | ORAL | ANDA | 26 sections |
Methylphenidate Hydrochloride(CD) | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5296 | CAPSULE, EXTENDED RELEASE | 20 mg | ORAL | ANDA | 26 sections |
Methylphenidate Hydrochloride(CD) | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5297 | CAPSULE, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 26 sections |
Methylphenidate Hydrochloride(CD) | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5298 | CAPSULE, EXTENDED RELEASE | 40 mg | ORAL | ANDA | 26 sections |
Methylphenidate Hydrochloride(LA) | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5346 | CAPSULE, EXTENDED RELEASE | 20 mg | ORAL | ANDA | 29 sections |
Methylphenidate Hydrochloride(LA) | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5347 | CAPSULE, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 29 sections |
Methylphenidate Hydrochloride(LA) | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-5348 | CAPSULE, EXTENDED RELEASE | 40 mg | ORAL | ANDA | 29 sections |
Methylphenidate Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1736 | CAPSULE, EXTENDED RELEASE | 10 mg | ORAL | ANDA | 15 sections |
Methylphenidate Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1737 | CAPSULE, EXTENDED RELEASE | 20 mg | ORAL | ANDA | 15 sections |
Methylphenidate Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1738 | CAPSULE, EXTENDED RELEASE | 30 mg | ORAL | ANDA | 15 sections |
Methylphenidate Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1739 | CAPSULE, EXTENDED RELEASE | 40 mg | ORAL | ANDA | 15 sections |
Methylphenidate Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1740 | CAPSULE, EXTENDED RELEASE | 50 mg | ORAL | ANDA | 15 sections |
Methylphenidate Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1741 | CAPSULE, EXTENDED RELEASE | 60 mg | ORAL | ANDA | 15 sections |
METHYLPHENIDATE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1800 | TABLET | 5 mg | ORAL | ANDA | 28 sections |
METHYLPHENIDATE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1801 | TABLET | 10 mg | ORAL | ANDA | 28 sections |
METHYLPHENIDATE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1802 | TABLET | 20 mg | ORAL | ANDA | 28 sections |
Methylphenidate Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-0896 | SOLUTION | 5 mg | ORAL | ANDA | 21 sections |
Methylphenidate Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0121-1792 | SOLUTION | 10 mg | ORAL | ANDA | 21 sections |
Methylphenidate Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-8155 | TABLET, FILM COATED, EXTENDED RELEASE | 18 mg | ORAL | ANDA | 33 sections |
Methylphenidate Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-8156 | TABLET, FILM COATED, EXTENDED RELEASE | 27 mg | ORAL | ANDA | 33 sections |
Methylphenidate Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-8157 | TABLET, FILM COATED, EXTENDED RELEASE | 36 mg | ORAL | ANDA | 33 sections |