amiodarone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antiarrhythmics	176	1951-25-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: amiodarone amidorone sedacoron amiodarone hydrochloride amiodarone HCl	An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance. Molecular weight: 645.32 Formula: C25H29I2NO3 CLOGP: 8.95 LIPINSKI: 2 HAC: 4 HDO: 0 TPSA: 42.68 ALOGS: -5.13 ROTB: 11 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

amiodarone
amidorone
sedacoron
amiodarone hydrochloride
amiodarone HCl

An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.

Molecular weight: 645.32
Formula: C25H29I2NO3
CLOGP: 8.95
LIPINSKI: 2
HAC: 4
HDO: 0
TPSA: 42.68
ALOGS: -5.13
ROTB: 11

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.20	g	O
0.20	g	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.70 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	41.37 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution)	60 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	1.90 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.00 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	820 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Dec. 24, 1985	FDA	WYETH PHARMS INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug interaction	1122.38	12.78	1171	51692	208584	56030620
Atrial fibrillation	992.11	12.78	819	52044	108078	56131126
Torsade de pointes	815.43	12.78	339	52524	12101	56227103
Bradycardia	796.68	12.78	592	52271	66912	56172292
Electrocardiogram QT prolonged	708.05	12.78	507	52356	54081	56185123
Hyperthyroidism	643.63	12.78	293	52570	13059	56226145
Acute kidney injury	411.18	12.78	777	52086	239986	55999218
Ventricular tachycardia	409.28	12.78	233	52630	16668	56222536
International normalised ratio increased	366.61	12.78	315	52548	43726	56195478
Pulmonary toxicity	342.43	12.78	161	52702	7722	56231482
Cardiac failure	339.98	12.78	402	52461	81691	56157513
Myxoedema coma	337.47	12.78	78	52785	328	56238876
Interstitial lung disease	331.50	12.78	334	52529	56729	56182475
Rheumatoid arthritis	263.46	12.78	27	52836	382577	55856627
Sinus bradycardia	262.68	12.78	162	52701	13424	56225780
Hypothyroidism	235.48	12.78	231	52632	37965	56201239
Ventricular fibrillation	223.00	12.78	135	52728	10817	56228387
Hyperkalaemia	221.96	12.78	256	52607	50609	56188595
Cardiogenic shock	219.12	12.78	155	52708	16170	56223034
Pain	210.21	12.78	189	52674	662995	55576209
Syncope	206.59	12.78	367	52496	107832	56131372
Haematoma	194.29	12.78	192	52671	31827	56207377
Gastrointestinal haemorrhage	192.78	12.78	293	52570	75658	56163546
Hyponatraemia	190.56	12.78	343	52520	101796	56137408
Hypotension	188.94	12.78	590	52273	249918	55989286
Tachyarrhythmia	182.66	12.78	86	52777	4135	56235069
Cardiac arrest	182.04	12.78	306	52557	86008	56153196
Joint swelling	163.85	12.78	36	52827	289764	55949440
Arthralgia	159.85	12.78	142	52721	501527	55737677
Thyroiditis	158.65	12.78	63	52800	1989	56237215
Renal failure	150.27	12.78	325	52538	110175	56129029
Shock haemorrhagic	143.06	12.78	95	52768	8938	56230266
Headache	138.90	12.78	194	52669	558850	55680354
Cardiac failure congestive	138.03	12.78	274	52589	87446	56151758
Synovitis	133.15	12.78	4	52859	161301	56077903
Sinus node dysfunction	131.75	12.78	70	52793	4364	56234840
Rash	130.70	12.78	163	52700	492884	55746320
Glossodynia	128.76	12.78	3	52860	152455	56086749
Arthropathy	128.11	12.78	18	52845	200257	56038947
Atrial flutter	127.55	12.78	89	52774	9080	56230124
Therapeutic product effect decreased	127.42	12.78	8	52855	169444	56069760
Drug intolerance	127.15	12.78	45	52818	264773	55974431
Alopecia	124.55	12.78	60	52803	293398	55945806
Arrhythmia	122.80	12.78	158	52705	34925	56204279
Drug ineffective	121.62	12.78	450	52413	918539	55320665
Systemic lupus erythematosus	120.46	12.78	14	52849	180064	56059140
Infusion related reaction	119.98	12.78	25	52838	208906	56030298
Sinusitis	119.05	12.78	21	52842	197560	56041644
Hypokalaemia	110.78	12.78	262	52601	94175	56145029
Lactic acidosis	103.58	12.78	146	52717	35200	56204004
Swelling	103.27	12.78	48	52815	239723	55999481
Multiple organ dysfunction syndrome	98.04	12.78	177	52686	52593	56186611
Long QT syndrome	95.47	12.78	50	52813	3026	56236178
Anaemia	95.26	12.78	499	52364	267012	55972192
Hypersensitivity	94.97	12.78	62	52801	256346	55982858
Cerebral haemorrhage	92.61	12.78	124	52739	28482	56210722
Labelled drug-drug interaction medication error	92.53	12.78	81	52782	11505	56227699
Ventricular arrhythmia	90.03	12.78	50	52813	3404	56235800
Wound	89.86	12.78	12	52851	138792	56100412
Mitral valve incompetence	88.76	12.78	97	52766	18056	56221148
Melaena	87.59	12.78	120	52743	28170	56211034
Nasopharyngitis	86.58	12.78	50	52813	220909	56018295
Fatigue	84.47	12.78	418	52445	788134	55451070
Cardio-respiratory arrest	83.62	12.78	170	52693	55151	56184053
Musculoskeletal stiffness	82.94	12.78	22	52841	155985	56083219
Ventricular extrasystoles	80.86	12.78	73	52790	10797	56228407
Hypoxia	80.72	12.78	165	52698	53732	56185472
Fall	79.57	12.78	591	52272	356919	55882285
Abdominal discomfort	79.40	12.78	86	52777	277188	55962016
Alveolitis	76.05	12.78	41	52822	2632	56236572
Cholestasis	75.65	12.78	109	52754	26804	56212400
Rhabdomyolysis	75.03	12.78	136	52727	40522	56198682
Pericarditis	73.99	12.78	8	52855	108915	56130289
Respiratory failure	73.37	12.78	226	52637	94836	56144368
Atrial tachycardia	71.19	12.78	37	52826	2204	56237000
Infection	68.07	12.78	53	52810	200153	56039051
Maternal exposure during pregnancy	67.26	12.78	48	52815	189505	56049699
Atrioventricular block	67.09	12.78	54	52809	6833	56232371
Cerebral haematoma	65.17	12.78	40	52823	3283	56235921
Renal injury	64.76	12.78	59	52804	8828	56230376
Injection site pain	63.22	12.78	16	52847	117102	56122102
Rectal haemorrhage	62.15	12.78	127	52736	41340	56197864
Pain in extremity	61.63	12.78	116	52747	297315	55941889
Product use issue	61.06	12.78	51	52812	185990	56053214
Toxicity to various agents	60.98	12.78	390	52473	224174	56015030
Haematoma muscle	58.55	12.78	25	52838	952	56238252
Brugada syndrome	58.00	12.78	19	52844	339	56238865
Arterial haemorrhage	57.93	12.78	29	52834	1596	56237608
Cardioversion	57.56	12.78	26	52837	1135	56238069
Atrioventricular block complete	57.07	12.78	51	52812	7443	56231761
Blood thyroid stimulating hormone increased	56.71	12.78	48	52815	6515	56232689
Haemorrhage	56.11	12.78	147	52716	56250	56182954
Hepatocellular injury	55.82	12.78	94	52769	26420	56212784
Discomfort	55.61	12.78	32	52831	141729	56097475
Orthopnoea	55.38	12.78	45	52818	5771	56233433
Infusion site phlebitis	55.26	12.78	13	52850	60	56239144
Therapeutic product effect incomplete	54.39	12.78	16	52847	106015	56133189
Psoriatic arthropathy	54.12	12.78	4	52859	74004	56165200
Lymphatic fistula	53.43	12.78	22	52841	764	56238440
Contraindicated product administered	53.04	12.78	58	52805	186228	56052976
Coronary artery disease	53.03	12.78	100	52763	30696	56208508
Femoral hernia incarcerated	53.02	12.78	22	52841	779	56238425
Migraine	52.73	12.78	9	52854	86788	56152416
Blood loss anaemia	52.63	12.78	51	52812	8246	56230958
Hypoaesthesia	52.62	12.78	34	52829	141457	56097747
Pulmonary hypertension	52.58	12.78	109	52754	35835	56203369
Lung disorder	52.23	12.78	137	52726	52460	56186744
Urticaria	52.15	12.78	36	52827	144640	56094564
Neuromyopathy	51.86	12.78	20	52843	583	56238621
Pulmonary fibrosis	51.70	12.78	97	52766	29661	56209543
Ischaemic stroke	51.46	12.78	71	52792	16771	56222433
Cardioactive drug level increased	51.34	12.78	29	52834	2040	56237164
Stomatitis	50.71	12.78	25	52838	120785	56118419
Acute respiratory distress syndrome	50.57	12.78	81	52782	21845	56217359
Weight increased	49.87	12.78	87	52776	229616	56009588
Drug level increased	49.78	12.78	78	52785	20647	56218557
Treatment failure	49.68	12.78	52	52811	170340	56068864
Faecaloma	49.59	12.78	47	52816	7394	56231810
Arthritis	49.54	12.78	16	52847	99836	56139368
Toxic skin eruption	49.35	12.78	58	52805	11681	56227523
Pancreatic steatosis	49.01	12.78	22	52841	946	56238258
Hyperglobulinaemia	47.77	12.78	8	52855	0	56239204
Exposure during pregnancy	47.73	12.78	35	52828	136307	56102897
Blood cholesterol increased	47.61	12.78	6	52857	72573	56166631
Respiratory distress	47.46	12.78	97	52766	31570	56207634
Haematuria	46.93	12.78	88	52775	26899	56212305
Product dose omission issue	46.80	12.78	75	52788	204678	56034526
Pyrexia	46.35	12.78	219	52644	418554	55820650
Muscle spasms	45.87	12.78	37	52826	137334	56101870
Haemarthrosis	45.76	12.78	31	52832	3013	56236191
Urinary retention	45.68	12.78	89	52774	27985	56211219
Wound infection pseudomonas	45.50	12.78	23	52840	1292	56237912
Dyspnoea	45.25	12.78	794	52069	591783	55647421
Injection site erythema	44.96	12.78	9	52854	77439	56161765
Myocardial infarction	44.48	12.78	189	52674	92681	56146523
Diarrhoea	44.48	12.78	385	52478	638122	55601082
Coagulopathy	44.34	12.78	70	52793	18646	56220558
Pruritus	44.22	12.78	151	52712	316472	55922732
Fibromyalgia	44.22	12.78	3	52860	59600	56179604
Psoriasis	43.99	12.78	16	52847	92676	56146528
Nodal rhythm	43.58	12.78	24	52839	1607	56237597
Septic shock	42.68	12.78	140	52723	60695	56178509
Keratopathy	42.53	12.78	17	52846	546	56238658
Thyrotoxic crisis	42.44	12.78	19	52844	812	56238392
Bundle branch block left	42.04	12.78	40	52823	6322	56232882
Left ventricular dysfunction	41.93	12.78	52	52811	11071	56228133
Corneal deposits	41.38	12.78	14	52849	277	56238927
Back pain	41.20	12.78	102	52761	237068	56002136
Cerebellar syndrome	39.89	12.78	30	52833	3437	56235767
Ill-defined disorder	39.72	12.78	8	52855	68535	56170669
Acute respiratory failure	39.62	12.78	89	52774	30905	56208299
Hepatic cyst	39.26	12.78	34	52829	4759	56234445
Hypomagnesaemia	39.13	12.78	78	52785	24937	56214267
Bradyarrhythmia	39.07	12.78	24	52839	1972	56237232
Ecchymosis	38.37	12.78	48	52815	10308	56228896
Asthma	38.12	12.78	30	52833	112740	56126464
Anuria	38.09	12.78	51	52812	11709	56227495
Cerebellar haematoma	37.91	12.78	14	52849	361	56238843
Tricuspid valve incompetence	37.71	12.78	54	52809	13199	56226005
Listless	37.66	12.78	26	52837	2606	56236598
Extravasation	37.47	12.78	24	52839	2123	56237081
Seroma	37.47	12.78	23	52840	1888	56237316
Respiratory acidosis	37.44	12.78	37	52826	6126	56233078
Extrasystoles	37.22	12.78	33	52830	4766	56234438
Subdural haematoma	36.95	12.78	54	52809	13445	56225759
Depression	36.60	12.78	71	52792	180046	56059158
Pleural effusion	36.42	12.78	168	52695	85312	56153892
Cardiac ablation	36.21	12.78	20	52843	1347	56237857
Injection site reaction	35.92	12.78	4	52859	53243	56185961
Irritable bowel syndrome	35.71	12.78	10	52853	68448	56170756
Device stimulation issue	35.60	12.78	9	52854	59	56239145
Alveolar proteinosis	35.58	12.78	13	52850	325	56238879
Nausea	35.25	12.78	506	52357	763672	55475532
Hypoglycaemia	35.24	12.78	124	52739	55691	56183513
Sudden death	34.69	12.78	44	52819	9581	56229623
Myalgia	34.46	12.78	44	52819	131981	56107223
Inflammatory marker increased	34.13	12.78	35	52828	6055	56233149
Off label use	34.11	12.78	346	52517	555834	55683370
Prothrombin time shortened	33.90	12.78	21	52842	1752	56237452
Reduced facial expression	33.65	12.78	21	52842	1775	56237429
Aortic valve stenosis	33.50	12.78	26	52837	3121	56236083
Agranulocytosis	33.47	12.78	69	52794	22590	56216614
Peripheral swelling	33.39	12.78	111	52752	234615	56004589
Craniocerebral injury	33.26	12.78	24	52839	2580	56236624
Spontaneous haematoma	33.20	12.78	16	52847	810	56238394
Head injury	33.18	12.78	73	52790	24993	56214211
Muscle haemorrhage	32.59	12.78	25	52838	2950	56236254
Cardiac disorder	32.54	12.78	106	52757	45781	56193423
Organising pneumonia	32.35	12.78	32	52831	5303	56233901
Mixed liver injury	32.35	12.78	28	52835	3916	56235288
Pneumonitis	32.13	12.78	83	52780	31481	56207723
Medication error	32.03	12.78	100	52763	42235	56196969
Hepatic failure	32.00	12.78	86	52777	33400	56205804
Right ventricular failure	31.76	12.78	56	52807	16323	56222881
Suicide attempt	31.01	12.78	8	52855	57828	56181376
Gastrooesophageal reflux disease	30.95	12.78	20	52843	83237	56155967
Cornea verticillata	30.92	12.78	9	52854	106	56239098
Arrhythmia supraventricular	30.78	12.78	16	52847	953	56238251
Anticoagulation drug level increased	30.49	12.78	10	52853	179	56239025
Subarachnoid haemorrhage	30.49	12.78	45	52818	11302	56227902
Hepatic enzyme increased	30.30	12.78	73	52790	171311	56067893
Abortion spontaneous	30.25	12.78	3	52860	43750	56195454
Chills	30.24	12.78	31	52832	102573	56136631
Haemorrhagic stroke	30.19	12.78	31	52832	5372	56233832
Iodine overload	29.86	12.78	5	52858	0	56239204
Renal impairment	29.62	12.78	152	52711	80561	56158643
Haemorrhagic diathesis	29.51	12.78	27	52836	4061	56235143
Oliguria	29.50	12.78	38	52825	8402	56230802
Overdose	29.41	12.78	185	52678	105645	56133559
Lower gastrointestinal haemorrhage	29.36	12.78	35	52828	7152	56232052
Ventricular tachyarrhythmia	29.30	12.78	9	52854	129	56239075
Insomnia	29.19	12.78	88	52775	191772	56047432
Rales	29.15	12.78	43	52820	10797	56228407
Pericardial haemorrhage	29.05	12.78	18	52845	1502	56237702
Glomerular filtration rate decreased	29.05	12.78	46	52817	12283	56226921
Acute hepatic failure	28.75	12.78	54	52809	16524	56222680
Mediastinal haematoma	28.31	12.78	8	52855	84	56239120
Knee arthroplasty	28.21	12.78	4	52859	44255	56194949
General physical health deterioration	28.03	12.78	263	52600	169747	56069457
White blood cell count decreased	27.97	12.78	47	52816	125943	56113261
Hypervolaemia	27.37	12.78	70	52793	26388	56212816
Intentional product use issue	27.33	12.78	32	52831	99701	56139503
Oedema peripheral	27.28	12.78	263	52600	170991	56068213
Myxoedema	27.27	12.78	8	52855	97	56239107
Herpes zoster	27.17	12.78	19	52844	75870	56163334
Goitre congenital	26.92	12.78	5	52858	4	56239200
Heparin-induced thrombocytopenia	26.91	12.78	26	52837	4188	56235016
Hepatitis acute	26.69	12.78	36	52827	8321	56230883
Subcutaneous haematoma	26.00	12.78	17	52846	1557	56237647
Cardiac failure chronic	25.79	12.78	25	52838	4042	56235162
Diverticulum intestinal	25.72	12.78	31	52832	6409	56232795
Nodal arrhythmia	25.59	12.78	15	52848	1132	56238072
Shock	25.14	12.78	60	52803	21668	56217536
Myopathy	25.06	12.78	38	52825	9774	56229430
Gastrointestinal disorder	25.06	12.78	42	52821	112660	56126544
Oesophageal squamous cell carcinoma	25.00	12.78	8	52855	132	56239072
Acute generalised exanthematous pustulosis	24.90	12.78	38	52825	9831	56229373
Drug hypersensitivity	24.82	12.78	154	52709	275051	55964153
Asthenia	24.80	12.78	456	52407	342517	55896687
Encephalopathy	24.50	12.78	81	52782	35244	56203960
Atrioventricular block first degree	24.50	12.78	31	52832	6734	56232470
Device capturing issue	24.48	12.78	6	52857	34	56239170
Coronary artery bypass	24.45	12.78	19	52844	2284	56236920
Central nervous system injury	24.41	12.78	8	52855	143	56239061
Pericardial effusion	24.18	12.78	68	52795	27107	56212097
Sinoatrial block	24.13	12.78	13	52850	833	56238371
Eosinophilia	23.83	12.78	56	52807	20021	56219183
Abdominal pain upper	23.55	12.78	87	52776	178226	56060978
Foreign body	23.51	12.78	18	52845	2118	56237086
Abdominal wall haematoma	23.42	12.78	20	52843	2747	56236457
Injection site bruising	23.38	12.78	4	52859	38517	56200687
Cardiac arrest neonatal	23.21	12.78	7	52856	94	56239110
Thrombocytopenia	23.08	12.78	212	52651	136012	56103192
Pulmonary alveolar haemorrhage	22.99	12.78	24	52839	4240	56234964
Electrocardiogram QRS complex prolonged	22.96	12.78	27	52836	5440	56233764
Blister	22.92	12.78	42	52821	108845	56130359
Transaminases increased	22.73	12.78	69	52794	28701	56210503
Hypoxic-ischaemic encephalopathy	22.70	12.78	23	52840	3922	56235282
Intra-abdominal haematoma	22.70	12.78	16	52847	1658	56237546
Liver function test abnormal	22.67	12.78	94	52769	45577	56193627
Musculoskeletal pain	22.27	12.78	26	52837	81126	56158078
Splenic haemorrhage	22.16	12.78	8	52855	193	56239011
Cardiac failure acute	22.15	12.78	34	52829	8839	56230365
Thyroxine increased	22.13	12.78	11	52852	596	56238608
Potentiating drug interaction	22.12	12.78	23	52840	4043	56235161
Retroperitoneal haemorrhage	22.11	12.78	19	52844	2631	56236573
Hepatic cytolysis	22.07	12.78	38	52825	10868	56228336
Constipation	22.05	12.78	106	52757	201837	56037367
Feeling abnormal	21.99	12.78	59	52804	133543	56105661
Splenic injury	21.90	12.78	8	52855	200	56239004
Presyncope	21.78	12.78	63	52800	25519	56213685
Acute pulmonary oedema	21.68	12.78	31	52832	7566	56231638
Bone pain	21.64	12.78	10	52853	50175	56189029
Retroperitoneal haematoma	21.61	12.78	19	52844	2714	56236490
Hypochromasia	21.34	12.78	9	52854	332	56238872
Prerenal failure	21.23	12.78	15	52848	1560	56237644
Paraesthesia	21.21	12.78	58	52805	130456	56108748
Lower respiratory tract infection	21.00	12.78	48	52815	114746	56124458
Influenza like illness	20.89	12.78	16	52847	60972	56178232
Cyanosis	20.88	12.78	46	52817	15764	56223440
Type 2 diabetes mellitus	20.74	12.78	9	52854	46853	56192351
Aortic arteriosclerosis	20.71	12.78	26	52837	5604	56233600
Pulmonary oedema	20.66	12.78	99	52764	51044	56188160
Cardioactive drug level above therapeutic	20.53	12.78	7	52856	142	56239062
Cardiac tamponade	20.51	12.78	23	52840	4403	56234801
Upper respiratory tract infection	20.48	12.78	22	52841	71266	56167938
Device pacing issue	20.43	12.78	6	52857	73	56239131
Drug-induced liver injury	20.42	12.78	75	52788	34387	56204817
Haemorrhage intracranial	20.22	12.78	40	52823	12715	56226489
Local anaesthetic systemic toxicity	20.16	12.78	11	52852	723	56238481
Neck pain	20.02	12.78	17	52846	61538	56177666
Palpitations	19.97	12.78	161	52702	99511	56139693
C-reactive protein abnormal	19.91	12.78	5	52858	36804	56202400
Injection site swelling	19.88	12.78	8	52855	43570	56195634
Red blood cell sedimentation rate increased	19.76	12.78	5	52858	36618	56202586
Blood creatinine increased	19.73	12.78	136	52727	80055	56159149
Wound dehiscence	19.73	12.78	23	52840	4592	56234612
Osteoarthritis	19.69	12.78	28	52835	80268	56158936
Anti-thyroid antibody positive	19.56	12.78	9	52854	410	56238794
Memory impairment	19.48	12.78	32	52831	86525	56152679
Dyschromatopsia	19.42	12.78	9	52854	417	56238787
Propionibacterium infection	19.37	12.78	5	52858	36	56239168
Hepatitis fulminant	19.03	12.78	19	52844	3185	56236019
Pelvic fracture	19.00	12.78	38	52825	12175	56227029
Escherichia infection	18.92	12.78	37	52826	11662	56227542
Subdural haemorrhage	18.91	12.78	18	52845	2846	56236358
Prothrombin time prolonged	18.90	12.78	32	52831	9028	56230176
Activated partial thromboplastin time prolonged	18.90	12.78	27	52836	6585	56232619
Oropharyngeal pain	18.83	12.78	31	52832	83757	56155447
Thyroiditis acute	18.75	12.78	6	52857	99	56239105
Optic disc haemorrhage	18.69	12.78	6	52857	100	56239104
Thyroxine free increased	18.60	12.78	11	52852	844	56238360
Anisocytosis	18.56	12.78	10	52853	641	56238563
Throat irritation	18.55	12.78	4	52859	32679	56206525
Hypoglycaemic seizure	18.52	12.78	9	52854	464	56238740
Intentional overdose	18.50	12.78	22	52841	68095	56171109
Altered visual depth perception	18.48	12.78	8	52855	315	56238889
Adverse event	18.37	12.78	15	52848	55361	56183843
Conduction disorder	18.29	12.78	13	52850	1365	56237839
Prescription drug used without a prescription	18.18	12.78	15	52848	1965	56237239
Fear	18.15	12.78	42	52821	14866	56224338
Ischaemic hepatitis	18.15	12.78	15	52848	1970	56237234
Night sweats	18.10	12.78	8	52855	41205	56197999
Thyroglobulin increased	18.10	12.78	5	52858	48	56239156
Anhedonia	18.07	12.78	33	52830	9881	56229323
Myocardial ischaemia	18.02	12.78	37	52826	12079	56227125
Chorea	18.00	12.78	13	52850	1399	56237805
Electrocardiogram PR prolongation	17.97	12.78	10	52853	683	56238521
Pharyngeal haematoma	17.92	12.78	5	52858	50	56239154
Febrile neutropenia	17.83	12.78	46	52817	105499	56133705
Congenital hypothyroidism	17.54	12.78	7	52856	224	56238980
Neovascular age-related macular degeneration	17.51	12.78	7	52856	225	56238979
Circulatory collapse	17.48	12.78	51	52812	20752	56218452
Haemorrhagic thyroid cyst	17.46	12.78	4	52859	16	56239188
Drug level above therapeutic	17.42	12.78	21	52842	4341	56234863
Chronic kidney disease	17.42	12.78	82	52781	41974	56197230
Ear infection	17.42	12.78	4	52859	31291	56207913
Petechiae	17.29	12.78	38	52825	13001	56226203
Ear pain	17.09	12.78	4	52859	30886	56208318
Head discomfort	17.06	12.78	36	52827	11978	56227226
Tri-iodothyronine increased	16.93	12.78	6	52857	137	56239067
Ataxia	16.90	12.78	40	52823	14363	56224841
Compensatory sweating	16.74	12.78	4	52859	20	56239184
Electrocardiogram T wave inversion	16.58	12.78	18	52845	3325	56235879
Apathy	16.47	12.78	28	52835	7926	56231278
Swelling face	16.45	12.78	17	52846	56052	56183152
Secondary hyperthyroidism	16.42	12.78	4	52859	22	56239182
Death	16.36	12.78	428	52435	340998	55898206
Dyspnoea at rest	16.29	12.78	19	52844	3794	56235410
Disease progression	16.16	12.78	48	52815	105125	56134079
Electrocardiogram QRS complex shortened	16.15	12.78	8	52855	430	56238774
Eosinophilic pneumonia	16.14	12.78	14	52849	1963	56237241
Impaired healing	16.13	12.78	36	52827	86805	56152399
Drug clearance decreased	16.13	12.78	12	52851	1352	56237852
Tubulointerstitial nephritis	16.12	12.78	43	52820	16622	56222582
Anaphylactic reaction	16.08	12.78	19	52844	58976	56180228
Cardiovascular insufficiency	16.07	12.78	12	52851	1360	56237844
Ejection fraction decreased	16.06	12.78	48	52815	19793	56219411
Kidney malrotation	15.99	12.78	4	52859	25	56239179
Gastroenteritis aeromonas	15.99	12.78	4	52859	25	56239179
Neutrophil count decreased	15.91	12.78	14	52849	49808	56189396
Low cardiac output syndrome	15.84	12.78	7	52856	290	56238914
Apnoea	15.67	12.78	26	52837	7216	56231988
Therapeutic response decreased	15.47	12.78	16	52847	52742	56186462
Endovenous ablation	15.38	12.78	3	52860	4	56239200
Lip swelling	15.36	12.78	3	52860	26269	56212935
Infective pericardial effusion	15.35	12.78	4	52859	30	56239174
Suicidal ideation	15.31	12.78	19	52844	57723	56181481
Electrocardiogram U wave present	15.07	12.78	5	52858	93	56239111
Optic atrophy	15.06	12.78	11	52852	1205	56237999
Splenic rupture	14.97	12.78	11	52852	1216	56237988
Coagulation test abnormal	14.95	12.78	9	52854	713	56238491
Atrioventricular block second degree	14.94	12.78	18	52845	3718	56235486
Sedation	14.94	12.78	7	52856	34847	56204357
Blood pressure increased	14.81	12.78	78	52785	145098	56094106
Congestive hepatopathy	14.79	12.78	15	52848	2561	56236643
Hyperchloraemia	14.78	12.78	9	52854	728	56238476
Cutaneous lupus erythematosus	14.75	12.78	15	52848	2569	56236635
Cardiovascular disorder	14.74	12.78	32	52831	10857	56228347
Renal function test abnormal	14.74	12.78	16	52847	2955	56236249
Oesophageal adenocarcinoma recurrent	14.71	12.78	4	52859	36	56239168
Illness	14.69	12.78	7	52856	34504	56204700
Supraventricular tachycardia	14.62	12.78	36	52827	13255	56225949
Therapy non-responder	14.45	12.78	22	52841	61333	56177871
Extradural haematoma	14.44	12.78	12	52851	1588	56237616
Electrocardiogram T wave abnormal	14.40	12.78	14	52849	2272	56236932
Paroxysmal arrhythmia	14.33	12.78	4	52859	40	56239164
Dehydration	14.32	12.78	219	52644	158606	56080598
Atrioventricular dissociation	14.26	12.78	6	52857	220	56238984
Optic neuropathy	14.26	12.78	13	52850	1947	56237257
Lung consolidation	14.20	12.78	18	52845	3916	56235288
Hypocoagulable state	14.20	12.78	10	52853	1035	56238169
Erythema	14.17	12.78	87	52776	155852	56083352
Electrocardiogram T wave alternans	14.16	12.78	4	52859	42	56239162
Photosensitivity reaction	14.10	12.78	36	52827	13557	56225647
Oral mucosa haematoma	14.02	12.78	3	52860	8	56239196
Hypovolaemic shock	13.99	12.78	21	52842	5352	56233852
Lung infiltration	13.85	12.78	36	52827	13702	56225502
Left ventricular failure	13.69	12.78	20	52843	4976	56234228
Haemoglobin decreased	13.69	12.78	189	52674	133948	56105256
Cerebrovascular accident	13.66	12.78	148	52715	99122	56140082
Sopor	13.65	12.78	47	52816	20875	56218329
Pulseless electrical activity	13.60	12.78	24	52839	7000	56232204
Eosinophilic pleural effusion	13.60	12.78	4	52859	49	56239155
Eructation	13.51	12.78	25	52838	7563	56231641
Cardiomegaly	13.48	12.78	40	52823	16427	56222777
Goitre	13.41	12.78	21	52842	5552	56233652
Foot deformity	13.35	12.78	3	52860	23822	56215382
Eosinophilia myalgia syndrome	13.30	12.78	3	52860	11	56239193
Aortic valve incompetence	13.30	12.78	21	52842	5591	56233613
Groin pain	13.28	12.78	28	52835	9312	56229892
Monoclonal gammopathy	13.24	12.78	8	52855	638	56238566
Bullous haemorrhagic dermatosis	13.17	12.78	4	52859	55	56239149
Respiratory alkalosis	13.11	12.78	14	52849	2537	56236667
Hepatitis toxic	13.10	12.78	15	52848	2937	56236267
Thyroiditis chronic	13.10	12.78	3	52860	12	56239192
Toxic epidermal necrolysis	13.08	12.78	48	52815	21994	56217210
Haemodynamic instability	13.06	12.78	26	52837	8303	56230901
Lymphocyte count decreased	12.95	12.78	5	52858	27934	56211270
Pancreatitis	12.85	12.78	14	52849	45066	56194138
Concomitant disease aggravated	12.85	12.78	26	52837	8400	56230804
Loss of consciousness	12.80	12.78	158	52705	109191	56130013
Arterial insufficiency	12.80	12.78	5	52858	151	56239053

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperthyroidism	1798.39	11.50	722	74358	8909	31613355
Pulmonary toxicity	692.88	11.50	310	74770	5067	31617197
Ventricular tachycardia	688.40	11.50	517	74563	23184	31599080
Atrial fibrillation	617.57	11.50	1025	74055	112758	31509506
Drug interaction	541.19	11.50	1384	73696	207159	31415105
Bradycardia	476.72	11.50	697	74383	68630	31553634
Interstitial lung disease	468.82	11.50	649	74431	60754	31561510
Cardiac failure	466.75	11.50	775	74305	85178	31537086
Thyroiditis	366.52	11.50	151	74929	1992	31620272
Hypothyroidism	337.02	11.50	304	74776	17643	31604621
Electrocardiogram QT prolonged	331.80	11.50	429	74651	37558	31584706
Torsade de pointes	318.80	11.50	200	74880	6650	31615614
Pulmonary fibrosis	271.87	11.50	261	74819	16399	31605865
Cardiogenic shock	262.75	11.50	294	74786	22114	31600150
Ventricular fibrillation	260.90	11.50	270	74810	18578	31603686
Thyrotoxic crisis	196.79	11.50	61	75019	321	31621943
International normalised ratio increased	180.29	11.50	357	74723	44866	31577398
Acute kidney injury	174.28	11.50	1195	73885	278519	31343745
Cardiac failure congestive	172.78	11.50	495	74585	78892	31543372
Pulmonary alveolar haemorrhage	151.99	11.50	127	74953	6639	31615625
Hypotension	149.80	11.50	911	74169	203707	31418557
Ejection fraction decreased	146.04	11.50	193	74887	17241	31605023
Multiple organ dysfunction syndrome	145.21	11.50	422	74658	67781	31554483
Ventricular arrhythmia	142.52	11.50	107	74973	4784	31617480
Appendicolith	140.11	11.50	113	74967	5618	31616646
Completed suicide	125.71	11.50	31	75049	91483	31530781
Atrial flutter	125.48	11.50	164	74916	14491	31607773
Pyrexia	121.22	11.50	346	74734	303494	31318770
Blood thyroid stimulating hormone increased	108.93	11.50	80	75000	3457	31618807
Lung disorder	104.21	11.50	234	74846	32078	31590186
Cardiac failure chronic	101.70	11.50	105	74975	7198	31615066
Acute respiratory distress syndrome	100.49	11.50	196	74884	24344	31597920
Sinus bradycardia	96.92	11.50	131	74949	11956	31610308
Appendicitis	96.13	11.50	127	74953	11338	31610926
Arthralgia	96.07	11.50	131	74949	151293	31470971
Cardiac arrest	93.29	11.50	438	74642	88624	31533640
Thyroid disorder	93.06	11.50	68	75012	2915	31619349
Myxoedema coma	92.49	11.50	32	75048	250	31622014
Arrhythmia	91.91	11.50	226	74854	32851	31589413
Febrile neutropenia	91.69	11.50	92	74988	121757	31500507
Atrioventricular block	90.92	11.50	99	74981	7216	31615048
Syncope	88.54	11.50	418	74662	84764	31537500
Organising pneumonia	87.36	11.50	85	74995	5425	31616839
Renal failure	86.17	11.50	543	74537	122787	31499477
Atrial tachycardia	84.43	11.50	55	75025	1952	31620312
Headache	79.97	11.50	200	74880	183452	31438812
Drug abuse	77.27	11.50	57	75023	87701	31534563
Diarrhoea	72.19	11.50	514	74566	351895	31270369
Seizure	72.02	11.50	78	75002	99690	31522574
N-terminal prohormone brain natriuretic peptide increased	70.89	11.50	51	75029	2133	31620131
Corneal deposits	70.45	11.50	24	75056	178	31622086
Cornea verticillata	68.96	11.50	17	75063	29	31622235
Stress	68.84	11.50	170	74910	24771	31597493
Hyperkalaemia	66.99	11.50	316	74764	64035	31558229
Cardiac failure acute	66.85	11.50	98	74982	9643	31612621
Pericardial haemorrhage	66.45	11.50	56	75024	2961	31619303
Hyperglobulinaemia	65.62	11.50	13	75067	0	31622264
Palpitations	65.07	11.50	205	74875	34378	31587886
Dyspnoea	64.80	11.50	1157	73923	342322	31279942
Infusion site phlebitis	64.76	11.50	17	75063	42	31622222
Product dose omission issue	62.34	11.50	96	74984	105490	31516774
Suicidal ideation	61.70	11.50	7	75073	36399	31585865
Venous pressure jugular increased	61.31	11.50	32	75048	743	31621521
Shock haemorrhagic	60.80	11.50	96	74984	10081	31612183
Rheumatoid arthritis	58.63	11.50	20	75060	47789	31574475
Anticoagulation drug level increased	57.80	11.50	27	75053	489	31621775
Cerebral haematoma	57.28	11.50	61	75019	4334	31617930
Atrioventricular block complete	57.09	11.50	85	74995	8480	31613784
Nasopharyngitis	57.07	11.50	40	75040	63205	31559059
Ventricular extrasystoles	55.69	11.50	97	74983	11045	31611219
Dyspnoea exertional	54.60	11.50	209	74871	38628	31583636
Pain in extremity	54.14	11.50	122	74958	116081	31506183
Haematuria	53.83	11.50	235	74845	46079	31576185
Pericardial effusion	53.80	11.50	145	74935	22278	31599986
Labelled drug-drug interaction medication error	53.71	11.50	105	74975	13058	31609206
Malignant neoplasm progression	53.49	11.50	65	75015	78933	31543331
Neutropenia	53.48	11.50	163	74917	140201	31482063
BRASH syndrome	52.73	11.50	22	75058	300	31621964
Neutrophil count decreased	52.56	11.50	22	75058	46372	31575892
Anhedonia	51.25	11.50	75	75005	7367	31614897
Rash	50.37	11.50	276	74804	201210	31421054
Gastrointestinal haemorrhage	47.73	11.50	347	74733	82202	31540062
Sinus node dysfunction	47.55	11.50	52	75028	3808	31618456
Cardioactive drug level increased	47.46	11.50	36	75044	1634	31620630
Asthma	47.01	11.50	21	75059	42590	31579674
Jugular vein distension	46.34	11.50	25	75055	622	31621642
Tachycardia induced cardiomyopathy	45.40	11.50	15	75065	100	31622164
Thyroxine increased	44.80	11.50	14	75066	76	31622188
Exercise tolerance decreased	44.40	11.50	55	75025	4603	31617661
Atrioventricular block first degree	44.20	11.50	61	75019	5676	31616588
Thyroxine free increased	43.57	11.50	18	75062	239	31622025
Phlebitis	42.88	11.50	48	75032	3607	31618657
Drug-induced liver injury	42.72	11.50	141	74939	24222	31598042
Hyponatraemia	42.53	11.50	310	74770	73489	31548775
Rectal haemorrhage	42.02	11.50	184	74896	36120	31586144
Keratopathy	41.84	11.50	21	75059	448	31621816
Fatigue	41.35	11.50	553	74527	334653	31287611
Goitre	40.80	11.50	32	75048	1527	31620737
Muscle spasms	40.41	11.50	62	75018	68256	31554008
Coronary artery bypass	39.98	11.50	53	75027	4746	31617518
Acute respiratory failure	39.44	11.50	151	74929	27904	31594360
Haematoma	39.06	11.50	136	74944	24003	31598261
Off label use	38.91	11.50	584	74496	346690	31275574
Musculoskeletal stiffness	38.80	11.50	25	75055	41300	31580964
Left ventricular failure	38.63	11.50	52	75028	4725	31617539
Injection site pain	38.31	11.50	17	75063	34617	31587647
Pneumonitis	38.29	11.50	159	74921	30493	31591771
Death	38.16	11.50	613	74467	359956	31262308
Cardiac tamponade	37.78	11.50	52	75028	4827	31617437
Therapeutic product effect incomplete	37.64	11.50	29	75051	43667	31578597
Renal injury	37.50	11.50	80	75000	10585	31611679
Ascites	37.39	11.50	194	74886	40819	31581445
Rhabdomyolysis	37.16	11.50	268	74812	63313	31558951
Subdural haematoma	37.10	11.50	114	74966	18857	31603407
Orthopnoea	37.08	11.50	51	75029	4730	31617534
Drug dependence	36.65	11.50	5	75075	22574	31599690
Deep vein thrombosis	36.03	11.50	55	75025	60681	31561583
Melaena	35.91	11.50	163	74917	32491	31589773
Pain	35.88	11.50	277	74803	186482	31435782
Hepatocellular injury	35.40	11.50	122	74958	21422	31600842
Pulmonary embolism	35.39	11.50	89	74991	81557	31540707
White blood cell count decreased	35.06	11.50	99	74981	87299	31534965
Back pain	34.93	11.50	137	74943	109276	31512988
Insomnia	34.77	11.50	112	74968	94724	31527540
Cytomegalovirus infection	34.62	11.50	8	75072	24699	31597565
Aggression	34.41	11.50	23	75057	37268	31584996
Cardioversion	34.10	11.50	23	75057	866	31621398
Renal impairment	33.95	11.50	333	74747	86016	31536248
Tachyarrhythmia	33.73	11.50	40	75040	3199	31619065
Coagulopathy	33.22	11.50	108	74972	18407	31603857
Infusion related reaction	33.09	11.50	39	75041	48016	31574248
Potentiating drug interaction	32.98	11.50	47	75033	4506	31617758
Myalgia	32.12	11.50	86	74994	77172	31545092
Sinusitis	32.06	11.50	24	75056	36672	31585592
Hypertransaminasaemia	32.02	11.50	45	75035	4259	31618005
Crepitations	31.89	11.50	37	75043	2891	31619373
Nodal rhythm	31.84	11.50	26	75054	1315	31620949
Rales	31.77	11.50	66	75014	8573	31613691
Platelet count decreased	31.72	11.50	144	74936	110291	31511973
Stomatitis	31.71	11.50	28	75052	39410	31582854
Asthenia	31.52	11.50	725	74355	224030	31398234
Pacemaker generated rhythm	31.16	11.50	10	75070	60	31622204
Gastrooesophageal reflux disease	31.10	11.50	21	75059	33850	31588414
Intentional product use issue	30.92	11.50	43	75037	49304	31572960
Nodal arrhythmia	30.92	11.50	21	75059	800	31621464
Fear	30.77	11.50	71	75009	9903	31612361
Gravitational oedema	30.75	11.50	19	75061	614	31621650
Mitochondrial aspartate aminotransferase increased	30.50	11.50	7	75073	7	31622257
Pleural effusion	30.47	11.50	291	74789	74629	31547635
Colitis ulcerative	30.32	11.50	4	75076	18525	31603739
Bundle branch block left	30.16	11.50	50	75030	5468	31616796
Disease progression	29.69	11.50	112	74968	90352	31531912
Respiratory failure	29.68	11.50	369	74711	101080	31521184
Spontaneous haematoma	29.57	11.50	17	75063	480	31621784
Long QT syndrome	29.47	11.50	32	75048	2324	31619940
Nausea	29.46	11.50	533	74547	307414	31314850
Prothrombin time prolonged	29.37	11.50	66	75014	9046	31613218
Anticoagulation drug level above therapeutic	29.29	11.50	29	75051	1890	31620374
Activated partial thromboplastin time prolonged	29.27	11.50	62	75018	8163	31614101
Optic neuropathy	29.06	11.50	28	75052	1765	31620499
Chills	29.00	11.50	85	74995	74065	31548199
Prostate cancer	28.69	11.50	28	75052	37573	31584691
Cerebral haemorrhage	28.39	11.50	153	74927	32659	31589605
Traumatic lung injury	28.09	11.50	23	75057	1168	31621096
Angiodysplasia	28.00	11.50	17	75063	532	31621732
Hypertension	27.99	11.50	183	74897	127917	31494347
Herpes zoster	27.85	11.50	21	75059	31972	31590292
Blood pressure increased	27.84	11.50	96	74984	79537	31542727
Device inappropriate shock delivery	27.78	11.50	8	75072	31	31622233
Intraocular haematoma	27.68	11.50	7	75073	14	31622250
Heparin-induced thrombocytopenia	27.57	11.50	47	75033	5259	31617005
Depression	27.54	11.50	116	74964	90699	31531565
Low cardiac output syndrome	27.50	11.50	17	75063	550	31621714
Blood loss anaemia	27.25	11.50	58	75022	7661	31614603
Psoriasis	27.05	11.50	43	75037	46676	31575588
Blood pressure fluctuation	27.03	11.50	10	75070	22726	31599538
Mucosal inflammation	27.01	11.50	25	75055	34402	31587862
Hypoaesthesia	26.73	11.50	58	75022	55964	31566300
Presyncope	26.64	11.50	96	74984	17232	31605032
Optic ischaemic neuropathy	26.52	11.50	28	75052	1969	31620295
Myoclonus	26.36	11.50	83	74997	13907	31608357
Injury	26.01	11.50	104	74976	19605	31602659
Influenza like illness	25.83	11.50	14	75066	25423	31596841
Xyphoid retraction	25.60	11.50	11	75069	162	31622102
Cardiac output decreased	25.58	11.50	19	75061	835	31621429
Hydrops foetalis	25.36	11.50	15	75065	447	31621817
Halo vision	25.36	11.50	11	75069	166	31622098
Accessory cardiac pathway	25.24	11.50	5	75075	0	31622264
Myelosuppression	24.95	11.50	3	75077	14917	31607347
Sedation	24.92	11.50	7	75073	18958	31603306
Acute pulmonary oedema	24.79	11.50	53	75027	7023	31615241
Diaphragmatic paralysis	24.75	11.50	15	75065	468	31621796
Pancreatitis	24.66	11.50	29	75051	35742	31586522
Pruritus	24.31	11.50	185	74895	124982	31497282
Haemodynamic instability	24.24	11.50	59	75021	8516	31613748
Haemothorax	24.20	11.50	36	75044	3588	31618676
Platelet distribution width increased	24.19	11.50	10	75070	133	31622131
Thyroid function test abnormal	24.18	11.50	17	75063	685	31621579
Dissociation	24.17	11.50	22	75058	1290	31620974
Antiacetylcholine receptor antibody positive	24.13	11.50	8	75072	54	31622210
Joint swelling	24.13	11.50	57	75023	53374	31568890
Cardiac murmur	24.09	11.50	51	75029	6711	31615553
Urinary tract infection	24.04	11.50	97	74983	76772	31545492
Hypersensitivity	23.97	11.50	61	75019	55682	31566582
International normalised ratio abnormal	23.92	11.50	33	75047	3069	31619195
Glomerular filtration rate decreased	23.85	11.50	72	75008	11793	31610471
Therapeutic product effect decreased	23.60	11.50	24	75056	31598	31590666
Fall	23.55	11.50	592	74488	185497	31436767
Migraine	23.35	11.50	3	75077	14177	31608087
Puncture site haematoma	23.29	11.50	10	75070	147	31622117
Blood glucose increased	23.18	11.50	71	75009	61012	31561252
Periorbital haemorrhage	22.98	11.50	9	75071	103	31622161
Toxic goitre	22.90	11.50	5	75075	3	31622261
Tachycardia foetal	22.74	11.50	13	75067	363	31621901
Left atrial enlargement	22.48	11.50	17	75063	768	31621496
Nephrolithiasis	22.47	11.50	19	75061	27320	31594944
Femoral artery aneurysm	22.41	11.50	10	75070	162	31622102
Atrial thrombosis	22.41	11.50	26	75054	2031	31620233
Blood phosphorus increased	22.37	11.50	39	75041	4443	31617821
Urine iodine increased	22.31	11.50	5	75075	4	31622260
Blood creatinine increased	22.30	11.50	315	74765	88763	31533501
Arteriosclerotic gangrene	22.23	11.50	8	75072	71	31622193
Plasma cell myeloma	21.96	11.50	65	75015	56466	31565798
Cardiorenal syndrome	21.93	11.50	16	75064	684	31621580
Cholestatic liver injury	21.80	11.50	25	75055	1929	31620335
Iodine uptake abnormal	21.79	11.50	5	75075	5	31622259
Cardiac ventricular disorder	21.78	11.50	11	75069	238	31622026
Urticaria	21.72	11.50	67	75013	57450	31564814
Gastrointestinal angiodysplasia	21.64	11.50	15	75065	591	31621673
Lymphocyte count decreased	21.51	11.50	11	75069	20638	31601626
Neonatal pneumonia	21.36	11.50	9	75071	126	31622138
Device pacing issue	21.31	11.50	6	75074	21	31622243
Diabetes mellitus	21.19	11.50	43	75037	42513	31579751
Ischaemic stroke	21.16	11.50	88	74992	16883	31605381
Neuropathy peripheral	20.90	11.50	100	74980	75549	31546715
Hyperglycaemia	20.71	11.50	34	75046	36442	31585822
Orthostatic hypertension	20.63	11.50	11	75069	267	31621997
Oedema peripheral	20.55	11.50	370	74710	109469	31512795
Subarachnoid haemorrhage	20.34	11.50	62	75018	10209	31612055
Glomerular filtration rate	20.17	11.50	8	75072	95	31622169
Anuria	20.15	11.50	60	75020	9754	31612510
Cardio-respiratory arrest	20.08	11.50	199	74881	51527	31570737
Sinoatrial block	20.04	11.50	13	75067	458	31621806
Left ventricular dysfunction	19.97	11.50	58	75022	9299	31612965
Neonatal hypotension	19.94	11.50	9	75071	150	31622114
Lupus pneumonitis	19.87	11.50	7	75073	58	31622206
General physical health deterioration	19.80	11.50	378	74702	113057	31509207
Bundle branch block	19.68	11.50	16	75064	804	31621460
Papilloedema	19.67	11.50	27	75053	2499	31619765
Anaemia macrocytic	19.64	11.50	29	75051	2871	31619393
Drug withdrawal syndrome	19.51	11.50	10	75070	18740	31603524
Respiratory distress	19.34	11.50	141	74939	33412	31588852
Ischaemic cardiomyopathy	19.32	11.50	43	75037	5854	31616410
Dyspnoea at rest	19.31	11.50	32	75048	3499	31618765
Supraventricular tachycardia	19.28	11.50	61	75019	10246	31612018
Lymphoid tissue hyperplasia	19.27	11.50	7	75073	64	31622200
Conjunctival haemorrhage	19.26	11.50	28	75052	2734	31619530
Swelling	19.24	11.50	37	75043	37321	31584943
Normocytic anaemia	19.22	11.50	24	75056	2025	31620239
Eosinophilia	19.15	11.50	107	74973	23146	31599118
Upper respiratory tract infection	19.07	11.50	25	75055	29397	31592867
Supine hypertension	19.03	11.50	11	75069	314	31621950
Aerophagia	18.99	11.50	6	75074	34	31622230
Depressed mood	18.85	11.50	9	75071	17566	31604698
Product use issue	18.79	11.50	70	75010	56689	31565575
Alopecia	18.77	11.50	13	75067	20682	31601582
Pulmonary oedema	18.65	11.50	174	74906	44328	31577936
Porphyria acute	18.56	11.50	11	75069	329	31621935
Drug resistance	18.43	11.50	17	75063	23436	31598828
Pseudolymphoma	18.15	11.50	13	75067	540	31621724
Foetal exposure during pregnancy	18.14	11.50	44	75036	40832	31581432
Withdrawal syndrome	18.08	11.50	3	75077	11714	31610550
Coma uraemic	18.03	11.50	6	75074	41	31622223
Iodine overload	17.96	11.50	4	75076	3	31622261
Osteonecrosis of jaw	17.92	11.50	9	75071	17062	31605202
Tumour lysis syndrome	17.90	11.50	7	75073	15378	31606886
Abnormal behaviour	17.88	11.50	18	75062	23810	31598454
Dyspepsia	17.87	11.50	31	75049	32522	31589742
Ecchymosis	17.83	11.50	44	75036	6406	31615858
Rhinorrhoea	17.71	11.50	17	75063	22995	31599269
Musculoskeletal pain	17.69	11.50	27	75053	29801	31592463
Accidental exposure to product	17.62	11.50	3	75077	11492	31610772
Blood thyroid stimulating hormone decreased	17.57	11.50	22	75058	1861	31620403
Neuroleptic malignant syndrome	17.55	11.50	9	75071	16860	31605404
Irritability	17.51	11.50	17	75063	22872	31599392
Oesophageal infection	17.47	11.50	10	75070	280	31621984
Secondary hyperthyroidism	17.43	11.50	4	75076	4	31622260
Pemphigoid	17.39	11.50	51	75029	8220	31614044
Loss of personal independence in daily activities	17.37	11.50	25	75055	28263	31594001
Lower respiratory tract infection	17.29	11.50	25	75055	28212	31594052
Orthostatic hypotension	17.29	11.50	107	74973	24012	31598252
Haemoptysis	17.27	11.50	133	74947	32056	31590208
Oropharyngeal pain	17.27	11.50	30	75050	31453	31590811
Cholestasis	17.20	11.50	110	74970	24965	31597299
Influenza	17.19	11.50	51	75029	44274	31577990
Muscle haemorrhage	17.00	11.50	30	75050	3450	31618814
Vascular purpura	16.89	11.50	19	75061	1435	31620829
Abdominal discomfort	16.80	11.50	64	75016	51503	31570761
Serotonin syndrome	16.76	11.50	12	75068	18761	31603503
Electrocardiogram PR prolongation	16.75	11.50	14	75066	732	31621532
Systemic inflammatory response syndrome	16.71	11.50	42	75038	6183	31616081
Bladder cancer	16.64	11.50	7	75073	14718	31607546
COVID-19	16.62	11.50	70	75010	54751	31567513
Decreased appetite	16.62	11.50	259	74821	152958	31469306
Cardiac pacemaker insertion	16.61	11.50	26	75054	2709	31619555
Ilium fracture	16.55	11.50	7	75073	99	31622165
Scrotal haematocoele	16.51	11.50	5	75075	24	31622240
Ejection fraction abnormal	16.44	11.50	15	75065	882	31621382
Haemorrhage intracranial	16.34	11.50	75	75005	15013	31607251
Thyroiditis acute	16.30	11.50	7	75073	103	31622161
Colitis	16.23	11.50	35	75045	33852	31588412
Product quality issue	16.17	11.50	9	75071	16102	31606162
Dry skin	16.16	11.50	22	75058	25459	31596805
Injection site erythema	16.15	11.50	7	75073	14455	31607809
Hospitalisation	16.11	11.50	62	75018	49745	31572519
Cardiac arrest neonatal	16.02	11.50	5	75075	27	31622237
Epistaxis	15.97	11.50	196	74884	53511	31568753
Infection	15.94	11.50	121	74959	81810	31540454
Hepatitis C	15.80	11.50	3	75077	10627	31611637
Basal cell carcinoma	15.73	11.50	12	75068	18167	31604097
Heart rate abnormal	15.73	11.50	20	75060	1718	31620546
Therapeutic response decreased	15.72	11.50	24	75056	26485	31595779
Hypervolaemia	15.71	11.50	85	74995	18166	31604098
Dysphagia	15.49	11.50	77	75003	57599	31564665
Hirsutism	15.47	11.50	8	75072	182	31622082
Hepatitis fulminant	15.42	11.50	30	75050	3716	31618548
Oesophageal achalasia	15.42	11.50	10	75070	352	31621912
Graft versus host disease	15.42	11.50	3	75077	10444	31611820
Cellulitis	15.38	11.50	60	75020	47958	31574306
Mitral valve incompetence	15.38	11.50	70	75010	13963	31608301
Ischaemic hepatitis	15.36	11.50	19	75061	1588	31620676
Fasting	15.20	11.50	4	75076	10	31622254
Systemic-pulmonary artery shunt	15.14	11.50	3	75077	0	31622264
Bone marrow granuloma	15.14	11.50	3	75077	0	31622264
Angioedema	15.06	11.50	36	75044	33582	31588682
Thyroxine free decreased	15.02	11.50	9	75071	275	31621989
Psoriatic arthropathy	14.94	11.50	15	75065	19868	31602396
Pseudarthrosis	14.92	11.50	6	75074	74	31622190
Diffuse vasculitis	14.71	11.50	6	75074	77	31622187
Hypophonesis	14.68	11.50	4	75076	12	31622252
Axonal neuropathy	14.67	11.50	15	75065	1016	31621248
Abdominal distension	14.65	11.50	184	74896	50500	31571764
Emotional distress	14.55	11.50	70	75010	14286	31607978
Deposit eye	14.46	11.50	5	75075	39	31622225
Non-compaction cardiomyopathy	14.46	11.50	5	75075	39	31622225
Amaurosis	14.39	11.50	12	75068	625	31621639
Bradyarrhythmia	14.29	11.50	21	75059	2070	31620194
Cell death	14.25	11.50	21	75059	2075	31620189
Lymphadenopathy	14.23	11.50	25	75055	26096	31596168
Conduction disorder	14.22	11.50	20	75060	1894	31620370
Bone marrow failure	14.20	11.50	28	75052	27980	31594284
Supraventricular extrasystoles	14.20	11.50	26	75054	3078	31619186
Myopathy	14.11	11.50	57	75023	10795	31611469
Injection site reaction	14.06	11.50	5	75075	11646	31610618
Arthropathy	14.05	11.50	22	75058	24029	31598235
Hepatitis cholestatic	14.02	11.50	43	75037	7103	31615161
Osteoporosis	13.93	11.50	5	75075	11578	31610686
Erectile dysfunction	13.90	11.50	15	75065	19220	31603044
Tri-iodothyronine decreased	13.83	11.50	5	75075	45	31622219
Pericarditis fungal	13.79	11.50	7	75073	153	31622111
Myxoedema	13.79	11.50	4	75076	16	31622248
Paranoia	13.67	11.50	4	75076	10551	31611713
Cardiac dysfunction	13.64	11.50	20	75060	1967	31620297
Chronotropic incompetence	13.60	11.50	4	75076	17	31622247
Osteonecrosis	13.58	11.50	8	75072	13876	31608388
Thyrotoxic periodic paralysis	13.52	11.50	6	75074	96	31622168
Hepatic cirrhosis	13.49	11.50	73	75007	15601	31606663
Mediastinal haemorrhage	13.46	11.50	5	75075	49	31622215
Lung infiltration	13.44	11.50	61	75019	12152	31610112
Leukopenia	13.44	11.50	81	74999	57747	31564517
Arteriosclerotic retinopathy	13.42	11.50	4	75076	18	31622246
Neoplasm progression	13.37	11.50	17	75063	20255	31602009
Localised infection	13.31	11.50	10	75070	15255	31607009
Fascial rupture	13.24	11.50	4	75076	19	31622245
Cardiothoracic ratio increased	13.24	11.50	4	75076	19	31622245
Abdominal pain upper	13.18	11.50	93	74987	63909	31558355
Alveolitis necrotising	13.07	11.50	4	75076	20	31622244
Subdural haematoma evacuation	13.07	11.50	4	75076	20	31622244
Toxic nodular goitre	13.07	11.50	4	75076	20	31622244
Myoglobin urine present	13.05	11.50	7	75073	172	31622092
Traumatic haemothorax	13.05	11.50	8	75072	255	31622009
Bone pain	13.00	11.50	16	75064	19335	31602929
Acute lung injury	12.99	11.50	16	75064	1331	31620933
Vomiting	12.96	11.50	418	74662	223555	31398709
Adrenal haematoma	12.95	11.50	5	75075	55	31622209
Flushing	12.92	11.50	33	75047	30095	31592169
Progressive multifocal leukoencephalopathy	12.87	11.50	3	75077	9210	31613054
Generalised tonic-clonic seizure	12.85	11.50	17	75063	19914	31602350
Nephroangiosclerosis	12.84	11.50	7	75073	178	31622086
Pulseless electrical activity	12.76	11.50	40	75040	6687	31615577
Ventricular dysfunction	12.65	11.50	27	75053	3573	31618691
Linear IgA disease	12.63	11.50	17	75063	1545	31620719
Ulcer haemorrhage	12.62	11.50	22	75058	2505	31619759
Viral infection	12.62	11.50	11	75069	15582	31606682
Drug intolerance	12.56	11.50	72	75008	51961	31570303
Tri-iodothyronine free decreased	12.56	11.50	5	75075	60	31622204
Depressed level of consciousness	12.51	11.50	48	75032	38553	31583711
Hyponatraemic syndrome	12.49	11.50	7	75073	188	31622076
Type 2 diabetes mellitus	12.49	11.50	10	75070	14774	31607490
Pulmonary vascular resistance abnormality	12.48	11.50	5	75075	61	31622203
Prothrombin time shortened	12.46	11.50	16	75064	1388	31620876
Palmar-plantar erythrodysaesthesia syndrome	12.43	11.50	11	75069	15472	31606792
Oedema genital	12.39	11.50	9	75071	382	31621882
Therapeutic drug monitoring analysis not performed	12.35	11.50	10	75070	500	31621764
Blood creatine increased	12.28	11.50	31	75049	4577	31617687
Hypersensitivity pneumonitis	12.25	11.50	16	75064	1412	31620852
Tri-iodothyronine increased	12.20	11.50	5	75075	65	31622199
Proteinuria	12.20	11.50	13	75067	16750	31605514
Dry gangrene	12.07	11.50	9	75071	398	31621866
Electrocardiogram low voltage	12.06	11.50	4	75076	27	31622237
Sinus arrhythmia	12.06	11.50	12	75068	787	31621477
Cardiac disorder	12.04	11.50	144	74936	39070	31583194
Iron deficiency anaemia	12.04	11.50	49	75031	9310	31612954
Psychomotor hyperactivity	12.01	11.50	3	75077	8784	31613480
Atrial conduction time prolongation	11.86	11.50	3	75077	6	31622258
Electrocardiogram QRS complex prolonged	11.85	11.50	29	75051	4200	31618064
Failure to suspend medication	11.82	11.50	9	75071	411	31621853
Arthritis	11.74	11.50	30	75050	27355	31594909
Septic shock	11.71	11.50	221	74859	65937	31556327
Neuromyopathy	11.71	11.50	13	75067	968	31621296
Wolff-Parkinson-White syndrome	11.71	11.50	7	75073	213	31622051
Optic nerve infarction	11.70	11.50	4	75076	30	31622234
Vascular pseudoaneurysm	11.62	11.50	19	75061	2054	31620210
Epilepsy	11.58	11.50	20	75060	21021	31601243
Mesenteric artery thrombosis	11.56	11.50	9	75071	425	31621839
Arterial haemorrhage	11.51	11.50	12	75068	832	31621432

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hyperthyroidism	2314.54	11.20	958	114422	19133	70793931
Drug interaction	1534.55	11.20	2439	112941	379002	70434062
Atrial fibrillation	1389.62	11.20	1602	113778	182746	70630318
Bradycardia	1196.79	11.20	1231	114149	123384	70689680
Ventricular tachycardia	1072.27	11.20	693	114687	35730	70777334
Torsade de pointes	1017.56	11.20	525	114855	17591	70795473
Pulmonary toxicity	1001.97	11.20	442	114938	10356	70802708
Electrocardiogram QT prolonged	936.31	11.20	898	114482	82619	70730445
Interstitial lung disease	813.13	11.20	925	114455	103760	70709304
Cardiac failure	734.92	11.20	1030	114350	142511	70670553
Acute kidney injury	554.44	11.20	1862	113518	472762	70340302
Thyroiditis	503.74	11.20	204	115176	3832	70809232
Hypothyroidism	499.19	11.20	485	114895	45270	70767794
Cardiogenic shock	473.39	11.20	425	114955	35882	70777182
International normalised ratio increased	473.10	11.20	619	114761	80107	70732957
Ventricular fibrillation	472.24	11.20	375	115005	26736	70786328
Myxoedema coma	388.16	11.20	109	115271	599	70812465
Rheumatoid arthritis	331.65	11.20	42	115338	291763	70521301
Sinus bradycardia	300.94	11.20	273	115107	23350	70789714
Arthralgia	294.51	11.20	233	115147	503157	70309907
Hypotension	287.03	11.20	1359	114021	403022	70410042
Pulmonary fibrosis	284.50	11.20	314	115066	33996	70779068
Headache	265.75	11.20	333	115047	580072	70232992
Syncope	264.75	11.20	727	114653	164982	70648082
Multiple organ dysfunction syndrome	262.52	11.20	559	114821	107956	70705108
Cardiac failure congestive	255.01	11.20	632	114748	134825	70678239
Cardiac arrest	246.21	11.20	692	114688	159142	70653922
Hyperkalaemia	242.88	11.20	536	114844	106055	70707009
Pain	242.47	11.20	407	114973	628409	70184655
Atrial flutter	237.77	11.20	224	115156	20103	70792961
Renal failure	235.98	11.20	760	114620	188310	70624754
Ventricular arrhythmia	222.92	11.20	146	115234	7684	70805380
Thyrotoxic crisis	217.74	11.20	80	115300	1140	70811924
Joint swelling	207.95	11.20	76	115304	253135	70559929
Alopecia	191.53	11.20	44	115336	198446	70614618
Hyponatraemia	191.14	11.20	634	114746	159453	70653611
Gastrointestinal haemorrhage	185.76	11.20	568	114812	136840	70676224
Haematoma	181.52	11.20	301	115079	48117	70764947
Nasopharyngitis	180.23	11.20	68	115312	222138	70590926
Tachyarrhythmia	179.25	11.20	118	115262	6264	70806800
Arrhythmia	179.11	11.20	325	115055	55818	70757246
Appendicolith	176.72	11.20	112	115268	5568	70807496
Pulmonary alveolar haemorrhage	175.33	11.20	141	115239	10228	70802836
Shock haemorrhagic	173.57	11.20	179	115201	17927	70795137
Synovitis	166.94	11.20	11	115369	129217	70683847
Sinus node dysfunction	162.19	11.20	116	115264	7053	70806011
Rash	161.48	11.20	371	115009	510191	70302873
Drug intolerance	161.07	11.20	83	115297	225604	70587460
Infusion related reaction	160.94	11.20	60	115320	197474	70615590
Sinusitis	158.32	11.20	40	115340	169155	70643909
Therapeutic product effect decreased	156.62	11.20	23	115357	142995	70670069
Atrioventricular block	156.44	11.20	144	115236	12544	70800520
Acute respiratory distress syndrome	154.01	11.20	256	115124	40998	70772066
Arthropathy	153.52	11.20	29	115351	150028	70663036
Labelled drug-drug interaction medication error	145.86	11.20	188	115192	23939	70789125
Lung disorder	143.30	11.20	336	115044	69148	70743916
Pain in extremity	142.86	11.20	195	115185	327887	70485177
Blood thyroid stimulating hormone increased	140.61	11.20	114	115266	8365	70804699
Pyrexia	140.10	11.20	512	114868	606440	70206624
Fatigue	138.59	11.20	782	114598	823537	69989527
Hypersensitivity	137.09	11.20	104	115276	229708	70583356
Swelling	136.51	11.20	68	115312	188471	70624593
Completed suicide	131.43	11.20	106	115274	227029	70586035
Rhabdomyolysis	128.56	11.20	395	114985	95365	70717699
Musculoskeletal stiffness	127.02	11.20	41	115339	147719	70665345
Ventricular extrasystoles	126.15	11.20	152	115228	18074	70794990
Haematuria	123.09	11.20	300	115080	63273	70749791
Cerebral haematoma	121.93	11.20	99	115281	7279	70805785
Organising pneumonia	121.85	11.20	113	115267	9937	70803127
Melaena	121.13	11.20	277	115103	56078	70756986
Hand deformity	119.08	11.20	5	115375	86477	70726587
Atrial tachycardia	117.35	11.20	74	115306	3646	70809418
Systemic lupus erythematosus	117.26	11.20	14	115366	101888	70711176
Pemphigus	113.67	11.20	5	115375	83031	70730033
Cardiac failure chronic	112.19	11.20	109	115271	10160	70802904
Hyperglobulinaemia	111.08	11.20	21	115359	3	70813061
Cerebral haemorrhage	108.37	11.20	258	115122	53606	70759458
Glossodynia	107.02	11.20	9	115371	86478	70726586
Long QT syndrome	106.50	11.20	80	115300	5247	70807817
Stomatitis	106.39	11.20	38	115342	128473	70684591
Rectal haemorrhage	106.14	11.20	290	115090	65541	70747523
Pericardial haemorrhage	105.71	11.20	73	115307	4195	70808869
Infusion site phlebitis	105.23	11.20	28	115352	121	70812943
Maternal exposure during pregnancy	104.59	11.20	29	115351	115316	70697748
Atrioventricular block complete	102.57	11.20	125	115255	15038	70798026
Injection site pain	102.22	11.20	32	115348	117587	70695477
Diarrhoea	101.90	11.20	802	114578	782539	70030525
Orthopnoea	101.17	11.20	99	115281	9309	70803755
Abdominal discomfort	94.97	11.20	126	115254	214532	70598532
Dyspnoea	93.30	11.20	1763	113617	768297	70044767
Cardioactive drug level increased	93.14	11.20	63	115317	3499	70809565
Appendicitis	92.81	11.20	125	115255	16608	70796456
Corneal deposits	92.01	11.20	33	115347	437	70812627
Febrile neutropenia	91.34	11.20	119	115261	204199	70608865
Product dose omission issue	90.86	11.20	133	115247	217335	70595729
Nausea	90.80	11.20	918	114462	851170	69961894
Cornea verticillata	90.33	11.20	24	115356	103	70812961
Cardiac failure acute	90.01	11.20	126	115254	17361	70795703
Hypoaesthesia	89.83	11.20	71	115309	153668	70659396
Asthma	89.79	11.20	42	115338	120751	70692313
Respiratory failure	88.93	11.20	523	114857	168212	70644852
Therapeutic product effect incomplete	88.63	11.20	42	115338	119840	70693224
Migraine	88.07	11.20	8	115372	72230	70740834
Back pain	87.18	11.20	195	115185	270957	70542107
Anaemia	87.11	11.20	1021	114359	402402	70410662
Renal injury	85.89	11.20	118	115262	15976	70797088
Ejection fraction decreased	85.57	11.20	168	115212	30594	70782470
Hepatocellular injury	83.41	11.20	212	115168	45879	70767185
Cardio-respiratory arrest	82.80	11.20	354	115026	100323	70712741
Subdural haematoma	81.49	11.20	160	115220	29138	70783926
Wound	80.35	11.20	30	115350	98702	70714362
Urticaria	80.28	11.20	88	115292	162961	70650103
Cholestasis	79.27	11.20	213	115167	47659	70765405
Anticoagulation drug level increased	78.17	11.20	33	115347	691	70812373
Product use issue	76.18	11.20	109	115271	179828	70633236
Acute respiratory failure	75.41	11.20	225	115155	53440	70759624
Muscle spasms	74.90	11.20	84	115296	153962	70659102
Coronary artery bypass	74.56	11.20	68	115312	5852	70807212
Lower respiratory tract infection	74.24	11.20	45	115335	111868	70701196
Pruritus	74.04	11.20	300	115080	345260	70467804
Pneumonitis	73.98	11.20	226	115154	54371	70758693
Respiratory distress	73.85	11.20	226	115154	54424	70758640
Atrioventricular block first degree	73.77	11.20	93	115287	11580	70801484
Pleural effusion	72.70	11.20	416	114964	132448	70680616
Keratopathy	71.97	11.20	34	115346	936	70812128
Coagulopathy	70.95	11.20	163	115217	33086	70779978
Lactic acidosis	70.90	11.20	250	115130	64774	70748290
Mitral valve incompetence	70.77	11.20	143	115237	26585	70786479
Hypokalaemia	70.64	11.20	409	114971	130779	70682285
Cardioversion	69.60	11.20	42	115338	1912	70811152
Off label use	69.28	11.20	825	114555	742235	70070829
Alveolitis	69.09	11.20	54	115326	3757	70809307
Injection site erythema	68.64	11.20	17	115363	72907	70740157
Blood loss anaemia	68.37	11.20	100	115280	14341	70798723
Renal impairment	68.14	11.20	434	114946	143503	70669561
Infection	67.39	11.20	152	115228	210633	70602431
Arthritis	66.97	11.20	38	115342	97942	70715122
Hypoxia	66.82	11.20	315	115065	93029	70720035
Ischaemic stroke	66.77	11.20	152	115228	30668	70782396
Myalgia	65.97	11.20	107	115273	167785	70645279
Insomnia	65.69	11.20	162	115218	217644	70595420
Fall	65.53	11.20	1050	114330	443046	70370018
Pericardial effusion	65.31	11.20	182	115198	41594	70771470
Fibromyalgia	65.13	11.20	3	115377	47871	70765193
Coronary artery disease	63.98	11.20	236	115144	62500	70750564
Anhedonia	63.81	11.20	96	115284	14117	70798947
Discomfort	63.74	11.20	47	115333	105389	70707675
Intentional product use issue	63.49	11.20	61	115319	120081	70692983
Psoriatic arthropathy	63.14	11.20	14	115366	64757	70748307
Venous pressure jugular increased	62.26	11.20	34	115346	1278	70811786
Peripheral swelling	61.60	11.20	189	115191	236374	70576690
Exposure during pregnancy	61.43	11.20	33	115347	87684	70725380
Gastrooesophageal reflux disease	60.99	11.20	36	115344	90803	70722261
Drug-induced liver injury	60.54	11.20	215	115165	55898	70757166
Tachycardia induced cardiomyopathy	60.26	11.20	18	115362	127	70812937
Cardiac tamponade	60.00	11.20	72	115308	8523	70804541
Bundle branch block left	59.69	11.20	79	115301	10320	70802744
Rales	59.52	11.20	103	115277	17032	70796032
Injection site reaction	59.50	11.20	6	115374	49846	70763218
Depression	59.21	11.20	149	115231	198825	70614239
Neutrophil count decreased	59.15	11.20	31	115349	83525	70729539
Palpitations	58.77	11.20	344	115036	110409	70702655
Psoriasis	58.06	11.20	45	115335	98388	70714676
Nodal arrhythmia	57.90	11.20	37	115343	1866	70811198
Herpes zoster	56.91	11.20	34	115346	85201	70727863
Arterial haemorrhage	56.82	11.20	40	115340	2371	70810693
Spontaneous haematoma	56.74	11.20	32	115348	1282	70811782
Anuria	56.69	11.20	109	115271	19544	70793520
White blood cell count decreased	56.59	11.20	120	115260	170021	70643043
Potentiating drug interaction	56.35	11.20	68	115312	8096	70804968
Nodal rhythm	56.21	11.20	43	115337	2898	70810166
Left ventricular dysfunction	56.03	11.20	103	115277	17854	70795210
Drug abuse	55.85	11.20	96	115284	147160	70665904
N-terminal prohormone brain natriuretic peptide increased	55.23	11.20	48	115332	3876	70809188
Seizure	53.94	11.20	132	115248	177830	70635234
Thyroid disorder	53.85	11.20	84	115296	12748	70800316
Suicidal ideation	53.59	11.20	23	115357	69573	70743491
Neuromyopathy	53.50	11.20	32	115348	1433	70811631
Dyspnoea exertional	53.47	11.20	261	115119	78169	70734895
Subarachnoid haemorrhage	52.41	11.20	105	115275	19399	70793665
Heparin-induced thrombocytopenia	52.40	11.20	69	115311	8968	70804096
Abdominal pain upper	52.32	11.20	152	115228	193450	70619614
Thyroxine increased	52.27	11.20	25	115355	708	70812356
Chills	51.68	11.20	98	115282	144688	70668376
Irritable bowel syndrome	51.61	11.20	10	115370	50840	70762224
Thyroxine free increased	51.37	11.20	29	115351	1164	70811900
Folliculitis	51.13	11.20	5	115375	42565	70770499
Ill-defined disorder	51.06	11.20	13	115367	54728	70758336
Eosinophilia	51.02	11.20	163	115217	40156	70772908
Pericarditis	50.88	11.20	38	115342	84667	70728397
Oropharyngeal pain	50.77	11.20	49	115331	96261	70716803
Activated partial thromboplastin time prolonged	50.65	11.20	84	115296	13421	70799643
Anticoagulation drug level above therapeutic	50.47	11.20	42	115338	3196	70809868
Influenza like illness	49.66	11.20	22	115358	65309	70747755
Left ventricular failure	49.62	11.20	66	115314	8662	70804402
Ascites	49.11	11.20	229	115151	67318	70745746
Presyncope	48.88	11.20	153	115227	37285	70775779
Musculoskeletal pain	48.73	11.20	45	115335	90282	70722782
Oedema peripheral	48.55	11.20	576	114804	227515	70585549
General physical health deterioration	48.47	11.20	592	114788	235439	70577625
Ecchymosis	48.29	11.20	85	115295	14247	70798817
Blood pressure increased	48.08	11.20	152	115228	188365	70624699
Septic shock	47.98	11.20	330	115050	111928	70701136
BRASH syndrome	46.26	11.20	22	115358	615	70812449
Blood pressure fluctuation	46.24	11.20	19	115361	58993	70754071
Iodine overload	46.22	11.20	9	115371	3	70813061
Jugular vein distension	45.47	11.20	28	115352	1322	70811742
Haemarthrosis	45.45	11.20	50	115330	5389	70807675
Toxic skin eruption	45.42	11.20	101	115279	20061	70793003
Drug level increased	44.84	11.20	146	115234	36323	70776741
Goitre	44.05	11.20	48	115332	5118	70807946
Malignant neoplasm progression	43.79	11.20	82	115298	121657	70691407
Sedation	43.77	11.20	11	115369	46720	70766344
Prothrombin time shortened	43.47	11.20	37	115343	2905	70810159
Bradyarrhythmia	43.26	11.20	42	115338	3911	70809153
Haemorrhage	42.96	11.20	258	115122	83557	70729507
Asthenia	42.85	11.20	1010	114370	456656	70356408
Muscle haemorrhage	42.24	11.20	50	115330	5834	70807230
Prothrombin time prolonged	42.12	11.20	86	115294	16104	70796960
Weight increased	42.04	11.20	227	115153	242104	70570960
Exercise tolerance decreased	41.81	11.20	59	115321	8189	70804875
Haemorrhage intracranial	41.78	11.20	111	115269	24666	70788398
Lymphatic fistula	41.51	11.20	22	115358	778	70812286
Femoral hernia incarcerated	41.33	11.20	22	115358	785	70812279
Glomerular filtration rate decreased	41.28	11.20	99	115281	20657	70792407
Fear	41.11	11.20	99	115281	20712	70792352
Drug dependence	40.84	11.20	6	115374	37315	70775749
Device pacing issue	40.76	11.20	12	115368	80	70812984
Cardiac murmur	40.70	11.20	72	115308	12114	70800950
Blood creatinine increased	40.69	11.20	383	114997	142618	70670446
C-reactive protein abnormal	40.42	11.20	7	115373	38572	70774492
Haemorrhagic stroke	40.16	11.20	65	115315	10177	70802887
Upper respiratory tract infection	39.87	11.20	42	115338	79232	70733832
Craniocerebral injury	39.75	11.20	43	115337	4548	70808516
Blood phosphorus increased	39.73	11.20	52	115328	6718	70806346
Rhinorrhoea	39.57	11.20	30	115350	66341	70746723
Low cardiac output syndrome	39.50	11.20	22	115358	860	70812204
Gravitational oedema	38.83	11.20	28	115352	1724	70811340
Myocardial infarction	38.53	11.20	438	114942	171207	70641857
Optic neuropathy	38.51	11.20	36	115344	3197	70809867
Haematoma muscle	38.21	11.20	31	115349	2276	70810788
Acute pulmonary oedema	38.21	11.20	74	115306	13338	70799726
Colitis ulcerative	38.19	11.20	5	115375	33918	70779146
Toxicity to various agents	38.11	11.20	851	114529	381321	70431743
Brugada syndrome	37.09	11.20	23	115357	1100	70811964
Cerebellar syndrome	36.81	11.20	44	115336	5187	70807877
Electrocardiogram PR prolongation	36.63	11.20	25	115355	1409	70811655
Blood cholesterol increased	36.27	11.20	31	115349	64573	70748491
Neutropenia	36.23	11.20	257	115123	256899	70556165
Haemothorax	36.21	11.20	43	115337	5034	70808030
Myopathy	36.18	11.20	88	115292	18524	70794540
Head injury	36.12	11.20	130	115250	34011	70779053
Optic ischaemic neuropathy	36.03	11.20	32	115348	2660	70810404
Pancreatic steatosis	35.74	11.20	22	115358	1038	70812026
Shock	35.44	11.20	145	115235	40280	70772784
Contraindicated product administered	35.40	11.20	107	115273	134505	70678559
Cardiac ablation	35.06	11.20	28	115352	2010	70811054
Blister	35.03	11.20	69	115311	100457	70712607
Atrial thrombosis	34.79	11.20	34	115346	3191	70809873
Drug hypersensitivity	34.73	11.20	267	115113	262192	70550872
Pulmonary oedema	34.63	11.20	241	115139	82037	70731027
Sinoatrial block	34.56	11.20	23	115357	1243	70811821
Pacemaker generated rhythm	34.45	11.20	10	115370	63	70813001
Wound infection pseudomonas	34.39	11.20	25	115355	1559	70811505
Osteoarthritis	34.34	11.20	42	115338	74105	70738959
Bone pain	34.31	11.20	20	115360	50802	70762262
Knee arthroplasty	34.28	11.20	7	115373	34294	70778770
Pulmonary hypertension	33.99	11.20	158	115222	46378	70766686
Ischaemic hepatitis	33.88	11.20	34	115346	3295	70809769
Lung infiltration	33.59	11.20	94	115286	21530	70791534
Phlebitis	33.49	11.20	53	115327	8141	70804923
Dyspnoea at rest	33.42	11.20	48	115332	6771	70806293
Extravasation	33.30	11.20	34	115346	3363	70809701
Type 2 diabetes mellitus	33.25	11.20	15	115365	44065	70768999
Hepatitis fulminant	33.24	11.20	47	115333	6534	70806530
Mitochondrial aspartate aminotransferase increased	33.12	11.20	7	115373	7	70813057
Hypervolaemia	32.92	11.20	140	115240	39566	70773498
Haemoptysis	32.78	11.20	168	115212	51284	70761780
Haemodynamic instability	32.57	11.20	76	115304	15582	70797482
Cytomegalovirus infection	32.47	11.20	12	115368	39746	70773318
Cardiac disorder	32.45	11.20	186	115194	59229	70753835
Cardiac output decreased	32.29	11.20	25	115355	1715	70811349
Tricuspid valve incompetence	32.28	11.20	82	115298	17735	70795329
Injection site swelling	32.07	11.20	15	115365	43142	70769922
Myxoedema	32.04	11.20	11	115369	127	70812937
Ischaemic cardiomyopathy	31.91	11.20	48	115332	7056	70806008
Hip arthroplasty	31.89	11.20	4	115376	28036	70785028
International normalised ratio abnormal	31.88	11.20	41	115339	5206	70807858
Hypertension	31.71	11.20	318	115062	295715	70517349
COVID-19	31.59	11.20	79	115301	105678	70707386
Angiodysplasia	31.52	11.20	19	115361	863	70812201
Mobility decreased	31.50	11.20	76	115304	102923	70710141
Adverse event	31.27	11.20	21	115359	49440	70763624
Hepatic failure	31.21	11.20	180	115200	57445	70755619
Swelling face	31.17	11.20	34	115346	63130	70749934
Lymphocyte count decreased	31.04	11.20	16	115364	43523	70769541
Red blood cell sedimentation rate increased	31.00	11.20	12	115368	38630	70774434
Respiratory acidosis	30.86	11.20	58	115322	10223	70802841
Osteonecrosis of jaw	30.86	11.20	14	115366	40988	70772076
Acute hepatic failure	30.68	11.20	107	115273	27565	70785499
Mixed liver injury	30.64	11.20	44	115336	6205	70806859
Hepatitis acute	30.40	11.20	69	115311	13893	70799171
Toxic goitre	30.29	11.20	7	115373	14	70813050
Injection site bruising	30.20	11.20	12	115368	38020	70775044
Treatment failure	29.66	11.20	127	115253	144015	70669049
Cardiovascular insufficiency	29.65	11.20	29	115351	2724	70810340
Xyphoid retraction	29.61	11.20	11	115369	162	70812902
Pancreatitis	29.55	11.20	35	115345	62633	70750431
Fungal infection	29.46	11.20	12	115368	37455	70775609
Anaemia macrocytic	29.33	11.20	39	115341	5116	70807948
Osteoporosis	29.29	11.20	22	115358	48885	70764179
Disease progression	29.28	11.20	143	115237	156529	70656535
Ventricular tachyarrhythmia	29.08	11.20	13	115367	314	70812750
Feeling hot	29.01	11.20	22	115358	48648	70764416
Oral herpes	28.63	11.20	3	115377	24183	70788881
Neck pain	28.56	11.20	40	115340	66617	70746447
Palmar-plantar erythrodysaesthesia syndrome	28.56	11.20	7	115373	30240	70782824
Orthostatic hypotension	28.27	11.20	162	115218	51581	70761483
Throat irritation	28.26	11.20	11	115369	35293	70777771
Suicide attempt	28.20	11.20	54	115326	79456	70733608
Loss of personal independence in daily activities	28.12	11.20	60	115320	84850	70728214
Deep vein thrombosis	27.97	11.20	90	115290	110952	70702112
Femoral artery aneurysm	27.95	11.20	11	115369	191	70812873
Intraocular haematoma	27.81	11.20	7	115373	23	70813041
Platelet distribution width increased	27.77	11.20	10	115370	134	70812930
Glomerular filtration rate	27.77	11.20	10	115370	134	70812930
Cholestatic liver injury	27.60	11.20	34	115346	4134	70808930
Bursitis	27.59	11.20	5	115375	26668	70786396
Hot flush	27.58	11.20	24	115356	49560	70763504
Abdominal wall haematoma	27.52	11.20	35	115345	4395	70808669
Mediastinal haematoma	27.48	11.20	11	115369	200	70812864
Cataract	27.40	11.20	30	115350	55615	70757449
Stress	27.39	11.20	197	115183	67769	70745295
Periorbital haemorrhage	27.38	11.20	11	115369	202	70812862
Cellulitis	27.20	11.20	77	115303	98851	70714213
Feeling abnormal	27.12	11.20	129	115251	142190	70670874
Night sweats	27.01	11.20	19	115361	43665	70769399
Mouth ulceration	27.01	11.20	11	115369	34338	70778726
Vomiting	26.89	11.20	747	114633	592364	70220700
Gastrointestinal angiodysplasia	26.88	11.20	18	115362	983	70812081
Ilium fracture	26.85	11.20	11	115369	213	70812851
Cerebellar haematoma	26.82	11.20	15	115365	591	70812473
Papilloedema	26.81	11.20	40	115340	5838	70807226
Myelosuppression	26.54	11.20	8	115372	30137	70782927
Right ventricular failure	26.33	11.20	88	115292	22186	70790878
Neoplasm progression	26.26	11.20	21	115359	45207	70767857
Antiacetylcholine receptor antibody positive	26.25	11.20	8	115372	61	70813003
Traumatic lung injury	26.18	11.20	25	115355	2280	70810784
Basal cell carcinoma	26.16	11.20	11	115369	33687	70779377
Acute coronary syndrome	26.15	11.20	82	115298	19997	70793067
Extrasystoles	26.10	11.20	43	115337	6831	70806233
Influenza	26.04	11.20	96	115284	113604	70699460
Impaired healing	25.95	11.20	51	115329	74323	70738741
Myoclonus	25.91	11.20	98	115282	26257	70786807
Lower gastrointestinal haemorrhage	25.89	11.20	67	115313	14653	70798411
Seroma	25.88	11.20	24	115356	2110	70810954
Puncture site haematoma	25.88	11.20	10	115370	165	70812899
Epistaxis	25.84	11.20	268	115112	102359	70710705
Flushing	25.63	11.20	60	115320	82112	70730952
Cardioactive drug level above therapeutic	25.56	11.20	11	115369	242	70812822
Memory impairment	25.55	11.20	72	115308	92569	70720495
Gastrointestinal disorder	25.49	11.20	87	115293	105340	70707724
Wheezing	25.37	11.20	74	115306	94096	70718968
Illness	25.29	11.20	10	115370	31781	70781283
Therapeutic response decreased	25.12	11.20	35	115345	58418	70754646
Hypertransaminasaemia	25.06	11.20	49	115331	8894	70804170
Nephrolithiasis	25.02	11.20	24	115356	47299	70765765
Hypoglycaemia	24.99	11.20	249	115131	94115	70718949
Arteriosclerotic gangrene	24.98	11.20	8	115372	73	70812991
Ear pain	24.89	11.20	7	115373	27592	70785472
Drug withdrawal syndrome	24.88	11.20	11	115369	32704	70780360
Anaphylactic reaction	24.81	11.20	53	115327	74921	70738143
Hepatitis cholestatic	24.79	11.20	60	115320	12590	70800474
Thyroiditis acute	24.78	11.20	10	115370	186	70812878
Eosinophilic pneumonia	24.73	11.20	35	115345	4870	70808194
Blood thyroid stimulating hormone decreased	24.71	11.20	37	115343	5417	70807647
Intra-abdominal haematoma	24.69	11.20	26	115354	2666	70810398
Urinary tract infection	24.69	11.20	272	115108	248497	70564567
Intentional overdose	24.64	11.20	80	115300	98355	70714709
Depressed mood	24.63	11.20	21	115359	43799	70769265
Erythema	24.55	11.20	207	115173	199356	70613708
Drug ineffective	24.29	11.20	1266	114114	938486	69874578
Medication error	24.12	11.20	167	115213	56745	70756319
Ear infection	24.09	11.20	8	115372	28328	70784736
Pulmonary embolism	23.82	11.20	152	115228	155715	70657349
Nasal congestion	23.82	11.20	44	115336	65628	70747436
Urine iodine increased	23.66	11.20	5	115375	5	70813059
Iodine uptake abnormal	23.66	11.20	5	115375	5	70813059
Haemorrhagic diathesis	23.64	11.20	37	115343	5630	70807434
Left atrial enlargement	23.54	11.20	17	115363	1049	70812015
Cystitis	23.46	11.20	25	115355	46916	70766148
Blood creatine increased	23.33	11.20	47	115333	8717	70804347
Platelet count decreased	23.23	11.20	182	115198	178040	70635024
Tri-iodothyronine increased	23.15	11.20	10	115370	222	70812842
Retroperitoneal haemorrhage	23.12	11.20	35	115345	5174	70807890
Acute generalised exanthematous pustulosis	23.00	11.20	66	115314	15331	70797733
Pemphigoid	22.81	11.20	62	115318	13960	70799104
Aortic valve incompetence	22.81	11.20	47	115333	8857	70804207
Device inappropriate shock delivery	22.78	11.20	7	115373	55	70813009
Alveolar proteinosis	22.66	11.20	14	115366	665	70812399
Vascular purpura	22.52	11.20	25	115355	2721	70810343
Secondary hyperthyroidism	22.35	11.20	6	115374	27	70813037
Cardiac pacemaker insertion	22.31	11.20	35	115345	5337	70807727
Accidental exposure to product	22.03	11.20	9	115371	28042	70785022
Diabetes mellitus	21.96	11.20	53	115327	71771	70741293
Jaundice	21.81	11.20	148	115232	49960	70763104
Halo vision	21.66	11.20	13	115367	586	70812478
Conduction disorder	21.57	11.20	26	115354	3092	70809972
Hepatic enzyme increased	21.56	11.20	158	115222	156832	70656232
Neonatal pneumonia	21.51	11.20	6	115374	32	70813032
Neonatal hypotension	21.51	11.20	6	115374	32	70813032
Acne	21.34	11.20	7	115373	24982	70788082
Supine hypertension	21.31	11.20	11	115369	368	70812696
Cell death	21.22	11.20	30	115350	4170	70808894
Supraventricular extrasystoles	21.19	11.20	37	115343	6161	70806903
Localised infection	21.06	11.20	14	115366	33144	70779920
Cyanosis	20.95	11.20	84	115296	23122	70789942
Electrocardiogram QRS complex prolonged	20.84	11.20	48	115332	9758	70803306
Mucosal inflammation	20.80	11.20	50	115330	67800	70745264
Device capturing issue	20.78	11.20	6	115374	37	70813027
Bundle branch block	20.77	11.20	18	115362	1448	70811616
Cardiomegaly	20.70	11.20	87	115293	24458	70788606
Product quality issue	20.66	11.20	12	115368	30549	70782515
Irritability	20.66	11.20	19	115361	38206	70774858
Pharyngitis	20.66	11.20	4	115376	20347	70792717
Myocardial ischaemia	20.58	11.20	86	115294	24114	70788950
Feeling cold	20.41	11.20	8	115372	25562	70787502
Skin disorder	20.41	11.20	12	115368	30345	70782719
Hepatotoxicity	20.40	11.20	132	115248	43854	70769210
Subcutaneous haematoma	20.33	11.20	23	115357	2556	70810508
Lupus pneumonitis	20.29	11.20	7	115373	82	70812982
Aerophagia	20.25	11.20	6	115374	41	70813023
Body temperature increased	20.15	11.20	21	115359	39813	70773251
Coma uraemic	20.13	11.20	6	115374	42	70813022
Musculoskeletal disorder	20.11	11.20	4	115376	19967	70793097
Oliguria	20.10	11.20	62	115318	14989	70798075
Conjunctival haemorrhage	19.96	11.20	33	115347	5257	70807807
Hypophonesis	19.73	11.20	5	115375	17	70813047
Paraesthesia	19.73	11.20	147	115233	145390	70667674
Inappropriate schedule of product administration	19.61	11.20	99	115281	107456	70705608
Joint stiffness	19.60	11.20	17	115363	35159	70777905
Central nervous system injury	19.52	11.20	8	115372	155	70812909
Orchitis	19.24	11.20	16	115364	1216	70811848
Hypoxic-ischaemic encephalopathy	19.22	11.20	39	115341	7269	70805795
Pseudolymphoma	19.21	11.20	15	115365	1042	70812022
Sciatica	19.18	11.20	8	115372	24619	70788445
Supraventricular tachycardia	19.13	11.20	73	115307	19637	70793427
Thyroid function test abnormal	19.13	11.20	24	115356	2973	70810091
Amaurosis	19.05	11.20	15	115365	1055	70812009
Diaphragmatic paralysis	18.96	11.20	15	115365	1062	70812002
Osteonecrosis	18.95	11.20	12	115368	29148	70783916
Amnesia	18.86	11.20	35	115345	52120	70760944
Atrioventricular block second degree	18.82	11.20	37	115343	6741	70806323
Sudden death	18.82	11.20	76	115304	20988	70792076
Aortic valve stenosis	18.80	11.20	31	115349	4928	70808136
Bone disorder	18.71	11.20	3	115377	17487	70795577
Viral infection	18.57	11.20	21	115359	38370	70774694
Acute interstitial pneumonitis	18.56	11.20	15	115365	1095	70811969
Arrhythmia supraventricular	18.51	11.20	19	115361	1891	70811173
Normocytic anaemia	18.45	11.20	26	115354	3604	70809460
Bundle branch block right	18.36	11.20	48	115332	10562	70802502
Conjunctivitis	18.21	11.20	7	115373	22629	70790435
Pulseless electrical activity	18.17	11.20	55	115325	13160	70799904
Respiratory disorder neonatal	18.16	11.20	6	115374	61	70813003
Blood pressure decreased	18.09	11.20	228	115152	91287	70721777
Intentional self-injury	17.99	11.20	15	115365	31635	70781429
Withdrawal syndrome	17.98	11.20	9	115371	24895	70788169
Crepitations	17.80	11.20	42	115338	8672	70804392
Thyroxine free decreased	17.74	11.20	14	115366	988	70812076
Heart transplant	17.72	11.20	16	115364	1359	70811705
Traumatic haemothorax	17.70	11.20	10	115370	402	70812662
Unevaluable event	17.68	11.20	145	115235	51918	70761146
Agranulocytosis	17.52	11.20	119	115261	40179	70772885
Oral pain	17.50	11.20	13	115367	29053	70784011
Listless	17.34	11.20	25	115355	3538	70809526
Local anaesthetic systemic toxicity	17.31	11.20	13	115367	852	70812212
Vascular pseudoaneurysm	17.31	11.20	24	115356	3277	70809787
Injection site haemorrhage	17.29	11.20	10	115370	25517	70787547
Plasma cell myeloma	17.29	11.20	61	115319	73140	70739924
Hyperglycaemia	17.29	11.20	51	115329	64621	70748443
Orthostatic hypertension	17.19	11.20	12	115368	702	70812362
Thrombotic microangiopathy	17.11	11.20	4	115376	17844	70795220
Wrong technique in product usage process	17.07	11.20	56	115324	68642	70744422
Atrioventricular dissociation	17.01	11.20	9	115371	317	70812747
Blood glucose increased	17	11.20	98	115282	102884	70710180
Neuralgia	16.96	11.20	13	115367	28590	70784474
Pain in jaw	16.93	11.20	27	115353	42642	70770422
Device issue	16.87	11.20	9	115371	24016	70789048
Tooth disorder	16.76	11.20	9	115371	23929	70789135
Gastroenteritis viral	16.66	11.20	7	115373	21448	70791616
Cardiorenal syndrome	16.49	11.20	16	115364	1488	70811576
Electrocardiogram RR interval prolonged	16.42	11.20	4	115376	11	70813053
Dysgeusia	16.37	11.20	35	115345	49467	70763597
Crying	16.33	11.20	7	115373	21192	70791872
Paranoia	16.32	11.20	4	115376	17284	70795780
Non-compaction cardiomyopathy	16.30	11.20	5	115375	39	70813025
Endovenous ablation	16.27	11.20	3	115377	0	70813064
Concomitant disease aggravated	16.27	11.20	50	115330	12064	70801000
Ocular hyperaemia	16.20	11.20	10	115370	24629	70788435
Hepatic cyst	16.19	11.20	31	115349	5540	70807524
Ulcer	16.19	11.20	11	115369	25743	70787321
Burning sensation	16.17	11.20	39	115341	52831	70760233
Anti-thyroid antibody positive	16.17	11.20	10	115370	476	70812588
Blood pressure systolic increased	16.16	11.20	44	115336	57215	70755849
Eye pain	16.12	11.20	19	115361	34083	70778981
Chronic kidney disease	16.11	11.20	161	115219	60896	70752168
Systemic inflammatory response syndrome	16.08	11.20	46	115334	10666	70802398
Scrotal oedema	16.04	11.20	15	115365	1333	70811731
Splenic injury	16.00	11.20	8	115372	250	70812814
Accessory cardiac pathway	15.93	11.20	4	115376	13	70813051
Full blood count abnormal	15.88	11.20	19	115361	33859	70779205
Neuropathy peripheral	15.88	11.20	131	115249	126765	70686299
Colitis	15.87	11.20	52	115328	63762	70749302
Sneezing	15.85	11.20	4	115376	16947	70796117
Transplant rejection	15.68	11.20	5	115375	18166	70794898
Anticoagulation drug level below therapeutic	15.67	11.20	15	115365	1372	70811692
Pericarditis fungal	15.63	11.20	7	115373	170	70812894
Foot deformity	15.62	11.20	7	115373	20648	70792416
Chorea	15.49	11.20	18	115362	2060	70811004
Procedural pain	15.46	11.20	5	115375	18004	70795060
Coagulation test abnormal	15.44	11.20	14	115366	1196	70811868
Toxic nodular goitre	15.39	11.20	5	115375	48	70813016
Bone erosion	15.36	11.20	3	115377	15170	70797894
Thyrotoxic periodic paralysis	15.36	11.20	6	115374	102	70812962
Subdural haemorrhage	15.32	11.20	30	115350	5451	70807613
Throat tightness	15.32	11.20	11	115369	25011	70788053
Obstructive airways disorder	15.31	11.20	12	115368	26101	70786963
Mental disorder	15.31	11.20	14	115366	28226	70784838
Paroxysmal arrhythmia	15.30	11.20	5	115375	49	70813015
Haemorrhagic thyroid cyst	15.28	11.20	4	115376	16	70813048
Reduced facial expression	15.28	11.20	19	115361	2333	70810731
Sopor	15.22	11.20	95	115285	31172	70781892
Rash pruritic	15.21	11.20	52	115328	62939	70750125
Intervertebral disc protrusion	15.18	11.20	8	115372	21495	70791569
Lung opacity	15.15	11.20	24	115356	3689	70809375
Electrocardiogram T wave abnormal	15.10	11.20	23	115357	3419	70809645
Dry skin	15.03	11.20	44	115336	55887	70757177
Anxiety	14.99	11.20	260	115120	220070	70592994
Diffuse vasculitis	14.95	11.20	6	115374	110	70812954
Neutrophil count increased	14.86	11.20	13	115367	26782	70786282
Ventricular remodelling	14.85	11.20	6	115374	112	70812952
Faecaloma	14.85	11.20	44	115336	10407	70802657
Congestive hepatopathy	14.82	11.20	25	115355	4049	70809015
Retroperitoneal haematoma	14.81	11.20	28	115352	4957	70808107
Hypovolaemic shock	14.80	11.20	45	115335	10792	70802272
Mesenteric artery thrombosis	14.73	11.20	10	115370	559	70812505
Fascial rupture	14.73	11.20	4	115376	19	70813045
Intraventricular haemorrhage	14.69	11.20	26	115354	4375	70808689
Limb discomfort	14.64	11.20	16	115364	29689	70783375
Thyroglobulin increased	14.62	11.20	5	115375	57	70813007
Serotonin syndrome	14.58	11.20	29	115351	42085	70770979
Inflammation	14.57	11.20	72	115308	78593	70734471
Alveolitis necrotising	14.56	11.20	4	115376	20	70813044
Treatment noncompliance	14.53	11.20	34	115346	46540	70766524
Diabetic ketoacidosis	14.43	11.20	18	115362	31494	70781570
Renal function test abnormal	14.38	11.20	25	115355	4149	70808915
Photosensitivity reaction	14.37	11.20	66	115314	19274	70793790
Hypothermia	14.36	11.20	69	115311	20525	70792539
Bone marrow failure	14.33	11.20	37	115343	48973	70764091
Therapeutic drug monitoring analysis not performed	14.32	11.20	15	115365	1529	70811535
Failure to suspend medication	14.28	11.20	9	115371	443	70812621
Thrombin time prolonged	14.22	11.20	8	115372	319	70812745
Dry eye	14.20	11.20	19	115361	32263	70780801
Brain natriuretic peptide increased	14.17	11.20	37	115343	8134	70804930
Generalised tonic-clonic seizure	14.16	11.20	29	115351	41632	70771432
Liver function test abnormal	14.14	11.20	157	115223	60989	70752075
Hepatojugular reflux	14.07	11.20	10	115370	602	70812462
Dissociation	14.02	11.20	22	115358	3354	70809710
Hypoglycaemic seizure	14.00	11.20	11	115369	771	70812293
Red blood cell sedimentation rate abnormal	13.90	11.20	7	115373	19296	70793768
C-reactive protein increased	13.87	11.20	114	115266	110403	70702661
Oesophageal infection	13.82	11.20	10	115370	619	70812445
Gastroenteritis aeromonas	13.81	11.20	4	115376	25	70813039
Oedema genital	13.78	11.20	9	115371	471	70812593
Ventricular dysfunction	13.68	11.20	29	115351	5575	70807489
Eye swelling	13.66	11.20	11	115369	23603	70789461
Device dislocation	13.64	11.20	10	115370	22497	70790567
Splenic haemorrhage	13.54	11.20	10	115370	639	70812425
Diverticulum intestinal	13.53	11.20	36	115344	8005	70805059
Sleep disorder	13.50	11.20	63	115317	69809	70743255
Sinus disorder	13.46	11.20	7	115373	18952	70794112
Adrenal haematoma	13.46	11.20	6	115374	144	70812920
Injection site warmth	13.45	11.20	3	115377	13822	70799242
Drug reaction with eosinophilia and systemic symptoms	13.43	11.20	149	115231	57864	70755200
Foreign body	13.40	11.20	19	115361	2649	70810415
Tooth infection	13.39	11.20	5	115375	16458	70796606
Lymphadenopathy	13.39	11.20	38	115342	48753	70764311
Live birth	13.38	11.20	3	115377	13776	70799288
Leukopenia	13.33	11.20	110	115270	106450	70706614
Vascular stent thrombosis	13.33	11.20	22	115358	3501	70809563
Nodule	13.28	11.20	8	115372	19961	70793103
Swollen tongue	13.27	11.20	25	115355	37021	70776043
Electrocardiogram QRS complex shortened	13.22	11.20	10	115370	663	70812401
Hypochromasia	13.20	11.20	10	115370	664	70812400
Graft versus host disease	13.20	11.20	4	115376	15019	70798045
Rash maculo-papular	13.20	11.20	133	115247	50412	70762652
Arteriosclerotic retinopathy	13.18	11.20	4	115376	30	70813034
Infective pericardial effusion	13.18	11.20	4	115376	30	70813034
Vascular graft	13.10	11.20	16	115364	1928	70811136
Axonal neuropathy	13.10	11.20	16	115364	1928	70811136
Altered visual depth perception	13.08	11.20	8	115372	373	70812691
Chest X-ray abnormal	13.06	11.20	33	115347	7111	70805953
Ventricular enlargement	13.03	11.20	9	115371	517	70812547
Drug clearance decreased	13.03	11.20	20	115360	2993	70810071
Hypernatraemia	13.00	11.20	48	115332	12713	70800351
Bronchitis	12.93	11.20	125	115255	117118	70695946
Hypocoagulable state	12.91	11.20	16	115364	1957	70811107
Blood triglycerides increased	12.90	11.20	8	115372	19656	70793408
Sinus arrhythmia	12.88	11.20	16	115364	1962	70811102
Colonic haematoma	12.86	11.20	5	115375	84	70812980
Electrocardiogram low voltage	12.85	11.20	4	115376	33	70813031
Neuroleptic malignant syndrome	12.83	11.20	14	115366	25993	70787071
Foot fracture	12.83	11.20	8	115372	19592	70793472
Amyloidosis	12.80	11.20	19	115361	2760	70810304
Toothache	12.80	11.20	7	115373	18423	70794641
Lymphoid tissue hyperplasia	12.80	11.20	7	115373	264	70812800
Weight decreased	12.78	11.20	396	114984	310092	70502972
Pulmonary haemorrhage	12.75	11.20	50	115330	13623	70799441
Aphthous ulcer	12.70	11.20	4	115376	14652	70798412
Kidney infection	12.65	11.20	8	115372	19447	70793617
Fasting	12.64	11.20	4	115376	35	70813029
Prerenal failure	12.61	11.20	21	115359	3365	70809699
Oesophageal achalasia	12.61	11.20	10	115370	711	70812353
Obesity	12.57	11.20	15	115365	26756	70786308
Carpal tunnel syndrome	12.56	11.20	6	115374	17051	70796013
Product storage error	12.55	11.20	4	115376	14537	70798527
Oesophageal adenocarcinoma recurrent	12.54	11.20	4	115376	36	70813028
Hyperthermia	12.46	11.20	57	115323	16614	70796450
Iron deficiency anaemia	12.44	11.20	72	115308	23000	70790064
Hospitalisation	12.36	11.20	81	115299	82487	70730577
Optic atrophy	12.33	11.20	15	115365	1800	70811264
Hepatitis	12.33	11.20	130	115250	49850	70763214
Toxic epidermal necrolysis	12.28	11.20	108	115272	39449	70773615
Haemoperitoneum	12.26	11.20	23	115357	4048	70809016
Wolff-Parkinson-White syndrome	12.24	11.20	7	115373	288	70812776
Electrocardiogram T wave inversion	12.24	11.20	26	115354	5005	70808059
Dry mouth	12.20	11.20	66	115314	70391	70742673
Secretion discharge	12.20	11.20	3	115377	12930	70800134
Lip swelling	12.18	11.20	23	115357	34031	70779033
Demyelinating polyneuropathy	12.18	11.20	14	115366	1583	70811481
Tachypnoea	12.11	11.20	84	115296	28554	70784510
Ventricular flutter	12.10	11.20	5	115375	99	70812965
Ventricular hypokinesia	12.07	11.20	35	115345	8177	70804887
Linear IgA disease	12.07	11.20	19	115361	2905	70810159
Sinus arrest	12.06	11.20	20	115360	3195	70809869
Paraesthesia oral	12.02	11.20	5	115375	15412	70797652
Pelvic fracture	12.01	11.20	43	115337	11218	70801846
Panic attack	11.95	11.20	11	115369	22108	70790956
Cardiac dysfunction	11.94	11.20	21	115359	3516	70809548
Microcytic anaemia	11.94	11.20	25	115355	4764	70808300
Transaminases increased	11.93	11.20	123	115257	46895	70766169
Postrenal failure	11.92	11.20	9	115371	595	70812469
Cyst	11.90	11.20	3	115377	12716	70800348
Lung consolidation	11.83	11.20	35	115345	8271	70804793
Blood cyanide increased	11.82	11.20	4	115376	44	70813020
Flatulence	11.81	11.20	28	115352	38153	70774911
Petechiae	11.79	11.20	62	115318	19110	70793954
Extradural haematoma	11.76	11.20	18	115362	2687	70810377
Wound dehiscence	11.69	11.20	29	115351	6179	70806885
Eosinophilia myalgia syndrome	11.67	11.20	3	115377	11	70813053
Purpura	11.66	11.20	59	115321	17916	70795148
Impaired work ability	11.65	11.20	6	115374	16334	70796730
Nephroangiosclerosis	11.63	11.20	7	115373	317	70812747
Dilatation ventricular	11.58	11.20	22	115358	3909	70809155
Optic disc haemorrhage	11.49	11.20	5	115375	113	70812951
Liver scan abnormal	11.44	11.20	4	115376	49	70813015
Laryngitis	11.33	11.20	4	115376	13627	70799437
Subdural haematoma evacuation	11.29	11.20	4	115376	51	70813013
Arterial insufficiency	11.25	11.20	7	115373	337	70812727
Therapy non-responder	11.24	11.20	76	115304	76839	70736225
Dialysis	11.21	11.20	57	115323	17345	70795719

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cardiac arrest neonatal	41.28	40.06	11	86	83	89612

Pharmacologic Action:

Source	Code	Description
ATC	C01BD01	CARDIOVASCULAR SYSTEM CARDIAC THERAPY ANTIARRHYTHMICS, CLASS I AND III Antiarrhythmics, class III
FDA EPC	N0000175426	Antiarrhythmic
CHEBI has role	CHEBI:35554	cardiovascular agent
MeSH PA	D000889	Anti-Arrhythmia Agents
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D065609	Cytochrome P-450 CYP1A2 Inhibitors
MeSH PA	D065688	Cytochrome P-450 CYP2C9 Inhibitors
MeSH PA	D065690	Cytochrome P-450 CYP2D6 Inhibitors
MeSH PA	D065692	Cytochrome P-450 CYP3A Inhibitors
MeSH PA	D065607	Cytochrome P-450 Enzyme Inhibitors
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D049990	Membrane Transport Modulators
MeSH PA	D065606	Metabolic Side Effects of Drugs and Substances
MeSH PA	D026902	Potassium Channel Blockers
MeSH PA	D026941	Sodium Channel Blockers
MeSH PA	D014665	Vasodilator Agents
FDA MoA	N0000182137	Cytochrome P450 2D6 Inhibitors
FDA MoA	N0000182138	Cytochrome P450 1A2 Inhibitors
FDA MoA	N0000182141	Cytochrome P450 3A4 Inhibitors
FDA MoA	N0000185503	P-Glycoprotein Inhibitors
FDA MoA	N0000185504	Cytochrome P450 2C9 Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Ventricular fibrillation	indication	71908006
Prevention of Ventricular Fibrillation	indication
Life-Threatening Ventricular Tachycardia	indication
Atrial fibrillation	off-label use	49436004	DOID:0060224
Cardioversion of Atrial Fibrillation	off-label use
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation	off-label use
Complete atrioventricular block	contraindication	27885002
Torsades de pointes	contraindication	31722008
Hyperthyroidism	contraindication	34486009	DOID:7998
Extrinsic allergic alveolitis	contraindication	37471005	DOID:841
Hypothyroidism	contraindication	40930008	DOID:1459
Hypokalemia	contraindication	43339004
Chronic heart failure	contraindication	48447003
Bradycardia	contraindication	48867003
Refractive keratoplasty by laser surgery	contraindication	58076004
Sinus node dysfunction	contraindication	60423000
Interstitial pneumonia	contraindication	64667001
Optic neuritis	contraindication	66760008	DOID:1210
Corneal deposit	contraindication	74460005	DOID:11547
Disorder of optic nerve	contraindication	77157004	DOID:1891
Pulmonary hemorrhage	contraindication	78144005
Cardiogenic shock	contraindication	89138009
Thyrotoxicosis	contraindication	90739004	DOID:7997
Prolonged QT interval	contraindication	111975006
Liver function tests abnormal	contraindication	166603001
Hypomagnesemia	contraindication	190855004
Second degree atrioventricular block	contraindication	195042002
Disease of liver	contraindication	235856003	DOID:409
Drug-induced hepatitis	contraindication	235876009
Pregnancy, function	contraindication	289908002
Peripheral nerve disease	contraindication	302226006
Eosinophilic asthma	contraindication	367542003	DOID:9498
Surgical procedure	contraindication	387713003
Breastfeeding (mother)	contraindication	413712001
Chronic lung disease	contraindication	413839001
Congenital long QT syndrome	contraindication	442917000
Syncope due to Bradycardia	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.72	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN	BLOCKER	IC50	5	WOMBAT-PK	CHEMBL
Cytochrome P450 3A4	Enzyme	P08684	CP3A4_HUMAN		Ki	6.22	WOMBAT-PK
Beta-1 adrenergic receptor	GPCR	P08588	ADRB1_HUMAN		IC50	4.70	WOMBAT-PK
Sodium channel protein type 5 subunit alpha	Ion channel	Q14524	SCN5A_HUMAN	BLOCKER	IC50	7.10	WOMBAT-PK
Mu-type opioid receptor	GPCR	P35372	OPRM_HUMAN		Ki	5.11	DRUG MATRIX
D(1A) dopamine receptor	GPCR	P21728	DRD1_HUMAN		Ki	5.34	DRUG MATRIX
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN		Ki	5.18	DRUG MATRIX
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		IC50	6.30	WOMBAT-PK
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		Ki	7	WOMBAT-PK
Thyroid hormone receptor alpha	Nuclear hormone receptor	P10827	THA_HUMAN		IC50	5.64	WOMBAT-PK
Thyroid hormone receptor beta	Nuclear hormone receptor	P10828	THB_HUMAN		IC50	6.22	WOMBAT-PK
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	Enzyme	Q15125	EBP_HUMAN		Ki	7.60	WOMBAT-PK
Multidrug resistance protein 1	Transporter	P08183	MDR1_HUMAN		Ki	5.30	WOMBAT-PK
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN		Ki	5.91	DRUG MATRIX
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Ki	5.65	DRUG MATRIX
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN		Ki	5.99	DRUG MATRIX
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	6.23	DRUG MATRIX
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	6.67	DRUG MATRIX
5-hydroxytryptamine receptor 6	GPCR	P50406	5HT6R_HUMAN		Ki	5.05	DRUG MATRIX
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	5.23	DRUG MATRIX
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	6.39	DRUG MATRIX
Histamine H2 receptor	GPCR	P25021	HRH2_HUMAN		Ki	4.98	DRUG MATRIX
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN		Ki	6.20	DRUG MATRIX
Muscarinic acetylcholine receptor M2	GPCR	P08172	ACM2_HUMAN		Ki	5.74	DRUG MATRIX
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN		Ki	6.17	DRUG MATRIX
Muscarinic acetylcholine receptor M4	GPCR	P08173	ACM4_HUMAN		Ki	6.30	DRUG MATRIX
Muscarinic acetylcholine receptor M5	GPCR	P08912	ACM5_HUMAN		Ki	5.97	DRUG MATRIX
Beta-3 adrenergic receptor	GPCR	P13945	ADRB3_HUMAN		Ki	4.50	DRUG MATRIX
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN		Ki	5.70	DRUG MATRIX
Adenosine receptor A3	GPCR	P0DMS8	AA3R_HUMAN		Ki	5.00	DRUG MATRIX
D(4) dopamine receptor	GPCR	P21917	DRD4_HUMAN		Ki	5.21	DRUG MATRIX
Kappa-type opioid receptor	GPCR	P41145	OPRK_HUMAN		Ki	5.18	DRUG MATRIX
Delta-type opioid receptor	GPCR	P41143	OPRD_HUMAN		Ki	5.55	DRUG MATRIX
Cytochrome P450 2C9	Enzyme	P11712	CP2C9_HUMAN		EC50	7.40	WOMBAT-PK
Voltage-dependent T-type calcium channel subunit alpha-1H	Ion channel	O95180	CAC1H_HUMAN		Ki	5.28	WOMBAT-PK
Endothelin-1 receptor	GPCR	P25101	EDNRA_HUMAN		Ki	4.79	DRUG MATRIX
Squalene monooxygenase	Enzyme	Q14534	ERG1_HUMAN		IC50	4.92	CHEMBL
Tyrosine-protein kinase Fyn	Kinase	P06241	FYN_HUMAN		IC50	6.09	DRUG MATRIX
Receptor tyrosine-protein kinase erbB-2	Kinase	P04626	ERBB2_HUMAN		IC50	5.04	DRUG MATRIX
Squalene synthase	Enzyme	P37268	FDFT_HUMAN		IC50	5.10	CHEMBL
C-C chemokine receptor type 2	GPCR	P41597	CCR2_HUMAN		Ki	5.37	DRUG MATRIX
Substance-K receptor	GPCR	P21452	NK2R_HUMAN		Ki	5.19	DRUG MATRIX
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4	Ion channel	Q9Y3Q4	HCN4_HUMAN		IC50	5.35	WOMBAT-PK
Potassium voltage-gated channel subfamily A member 7	Ion channel	Q96RP8	KCNA7_HUMAN		IC50	6	WOMBAT-PK
B2 bradykinin receptor	GPCR	P30411	BKRB2_HUMAN		Ki	5.12	DRUG MATRIX
Melanocortin receptor 4	GPCR	P32245	MC4R_HUMAN		Ki	4.88	DRUG MATRIX
Melanocortin receptor 5	GPCR	P33032	MC5R_HUMAN		Ki	5.05	DRUG MATRIX
Melanocortin receptor 3	GPCR	P41968	MC3R_HUMAN		Ki	4.97	DRUG MATRIX
C-C chemokine receptor type 4	GPCR	P51679	CCR4_HUMAN		Ki	4.94	DRUG MATRIX
THAP domain-containing protein 1	Unclassified	Q9NVV9	THAP1_HUMAN		IC50	6.19	WOMBAT-PK
NAD-dependent deacetylase sirtuin 3	Enzyme	Q9NTG7	SIR3_HUMAN		EC50	5.49	CHEMBL
Lysine-specific demethylase PHF2	Enzyme	O75151	PHF2_HUMAN		IC50	4.08	CHEMBL
Lysine-specific demethylase 5A	Enzyme	P29375	KDM5A_HUMAN		IC50	4	CHEMBL
Lysine-specific demethylase 7A	Enzyme	Q6ZMT4	KDM7A_HUMAN		IC50	4.10	CHEMBL
Androgen receptor	Transcription factor		ANDR_RAT		Ki	4.55	DRUG MATRIX
Lethal factor	Enzyme		LEF_BACAN		IC50	5.46	CHEMBL
5-hydroxytryptamine receptor 1B	GPCR		5HT1B_RAT		Ki	4.41	DRUG MATRIX
Membrane-associated progesterone receptor component 1	Membrane receptor		PGRC1_RAT		IC50	6.93	DRUG MATRIX
C-8 sterol isomerase	Enzyme		ERG2_YEAST		Ki	7.21	CHEMBL
Cruzipain	Enzyme		CYSP_TRYCR		IC50	5.40	CHEMBL
Sodium channel protein type 5 subunit alpha	Ion channel		SCN5A_RAT	BLOCKER	IC50	5.70	IUPHAR

External reference:

ID	Source
4019606	VUID
N0000147701	NUI
D00636	KEGG_DRUG
19774-82-4	SECONDARY_CAS_RN
203114	RXNORM
C0002598	UMLSCUI
CHEBI:2663	CHEBI
BBI	PDB_CHEM_ID
CHEMBL633	ChEMBL_ID
CHEMBL1083993	ChEMBL_ID
D000638	MESH_DESCRIPTOR_UI
DB01118	DRUGBANK_ID
2566	IUPHAR_LIGAND_ID
2012	INN_ID
N3RQ532IUT	UNII
2157	PUBCHEM_CID
000629	NDDF
004484	NDDF
372821002	SNOMEDCT_US
52574003	SNOMEDCT_US
69236009	SNOMEDCT_US
4018065	VANDF
4019606	VANDF
13960	MMSL
4177	MMSL
d00002	MMSL

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Amiodarone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9875	INJECTION, SOLUTION	50 mg	INTRAVENOUS	ANDA	26 sections
Amiodarone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9875	INJECTION, SOLUTION	50 mg	INTRAVENOUS	ANDA	26 sections
Amiodarone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0185-0144	TABLET	200 mg	ORAL	ANDA	27 sections
Pacerone	HUMAN PRESCRIPTION DRUG LABEL	1	0245-0144	TABLET	100 mg	ORAL	ANDA	30 sections
Pacerone	HUMAN PRESCRIPTION DRUG LABEL	1	0245-0145	TABLET	400 mg	ORAL	ANDA	27 sections
Pacerone	HUMAN PRESCRIPTION DRUG LABEL	1	0245-0145	TABLET	400 mg	ORAL	ANDA	27 sections
Pacerone	HUMAN PRESCRIPTION DRUG LABEL	1	0245-0147	TABLET	200 mg	ORAL	ANDA	30 sections
Pacerone	HUMAN PRESCRIPTION DRUG LABEL	1	0245-1645	TABLET	400 mg	ORAL	ANDA	30 sections
Amiodarone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9815	INJECTION, SOLUTION	50 mg	INTRAVENOUS	ANDA	16 sections
Amiodarone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9815	INJECTION, SOLUTION	50 mg	INTRAVENOUS	ANDA	16 sections
Amiodarone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0404-9815	INJECTION, SOLUTION	50 mg	INTRAVENOUS	ANDA	16 sections
Amiodarone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8258	TABLET	200 mg	ORAL	ANDA	27 sections
Amiodarone hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6556	TABLET	200 mg	ORAL	ANDA	19 sections
Amiodarone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6993	TABLET	200 mg	ORAL	ANDA	28 sections
Amiodarone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	16714-843	TABLET	100 mg	ORAL	ANDA	28 sections
Amiodarone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	16714-844	TABLET	200 mg	ORAL	ANDA	28 sections
Amiodarone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	16714-845	TABLET	400 mg	ORAL	ANDA	28 sections
Amiodarone hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	21695-796	TABLET	200 mg	ORAL	ANDA	25 sections
amiodarone hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	25021-302	INJECTION, SOLUTION	50 mg	INTRAVENOUS	ANDA	28 sections
amiodarone hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	25021-302	INJECTION, SOLUTION	50 mg	INTRAVENOUS	ANDA	28 sections
Amiodarone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	29300-359	TABLET	200 mg	ORAL	ANDA	19 sections
Amiodarone HCl	HUMAN PRESCRIPTION DRUG LABEL	1	42494-307	TABLET	100 mg	ORAL	ANDA	29 sections
Amiodarone HCl	HUMAN PRESCRIPTION DRUG LABEL	1	42494-308	TABLET	200 mg	ORAL	ANDA	29 sections
Amiodarone HCl	HUMAN PRESCRIPTION DRUG LABEL	1	42494-309	TABLET	400 mg	ORAL	ANDA	29 sections
Nexterone	HUMAN PRESCRIPTION DRUG LABEL	1	43066-150	INJECTION, SOLUTION	1.50 mg	INTRAVENOUS	NDA	25 sections
Nexterone	HUMAN PRESCRIPTION DRUG LABEL	1	43066-360	INJECTION, SOLUTION	1.80 mg	INTRAVENOUS	NDA	25 sections
Amiodarone Hydrochloride	Human Prescription Drug Label	1	50090-3015	TABLET	200 mg	ORAL	ANDA	30 sections
Amiodarone Hydrochloride	Human Prescription Drug Label	1	50090-3015	TABLET	200 mg	ORAL	ANDA	30 sections
Amiodarone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	50090-3496	TABLET	200 mg	ORAL	ANDA	27 sections
Amiodarone Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	50090-5062	TABLET	200 mg	ORAL	ANDA	27 sections