amiodarone ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antiarrhythmics 176 1951-25-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • amiodarone
  • amidorone
  • sedacoron
  • amiodarone hydrochloride
  • amiodarone HCl
An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
  • Molecular weight: 645.32
  • Formula: C25H29I2NO3
  • CLOGP: 8.95
  • LIPINSKI: 2
  • HAC: 4
  • HDO: 0
  • TPSA: 42.68
  • ALOGS: -5.13
  • ROTB: 11

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.20 g O
0.20 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.70 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 41.37 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 60 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.90 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.00 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 820 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 24, 1985 FDA WYETH PHARMS INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug interaction 1122.38 12.78 1171 51692 208584 56030620
Atrial fibrillation 992.11 12.78 819 52044 108078 56131126
Torsade de pointes 815.43 12.78 339 52524 12101 56227103
Bradycardia 796.68 12.78 592 52271 66912 56172292
Electrocardiogram QT prolonged 708.05 12.78 507 52356 54081 56185123
Hyperthyroidism 643.63 12.78 293 52570 13059 56226145
Acute kidney injury 411.18 12.78 777 52086 239986 55999218
Ventricular tachycardia 409.28 12.78 233 52630 16668 56222536
International normalised ratio increased 366.61 12.78 315 52548 43726 56195478
Pulmonary toxicity 342.43 12.78 161 52702 7722 56231482
Cardiac failure 339.98 12.78 402 52461 81691 56157513
Myxoedema coma 337.47 12.78 78 52785 328 56238876
Interstitial lung disease 331.50 12.78 334 52529 56729 56182475
Rheumatoid arthritis 263.46 12.78 27 52836 382577 55856627
Sinus bradycardia 262.68 12.78 162 52701 13424 56225780
Hypothyroidism 235.48 12.78 231 52632 37965 56201239
Ventricular fibrillation 223.00 12.78 135 52728 10817 56228387
Hyperkalaemia 221.96 12.78 256 52607 50609 56188595
Cardiogenic shock 219.12 12.78 155 52708 16170 56223034
Pain 210.21 12.78 189 52674 662995 55576209
Syncope 206.59 12.78 367 52496 107832 56131372
Haematoma 194.29 12.78 192 52671 31827 56207377
Gastrointestinal haemorrhage 192.78 12.78 293 52570 75658 56163546
Hyponatraemia 190.56 12.78 343 52520 101796 56137408
Hypotension 188.94 12.78 590 52273 249918 55989286
Tachyarrhythmia 182.66 12.78 86 52777 4135 56235069
Cardiac arrest 182.04 12.78 306 52557 86008 56153196
Joint swelling 163.85 12.78 36 52827 289764 55949440
Arthralgia 159.85 12.78 142 52721 501527 55737677
Thyroiditis 158.65 12.78 63 52800 1989 56237215
Renal failure 150.27 12.78 325 52538 110175 56129029
Shock haemorrhagic 143.06 12.78 95 52768 8938 56230266
Headache 138.90 12.78 194 52669 558850 55680354
Cardiac failure congestive 138.03 12.78 274 52589 87446 56151758
Synovitis 133.15 12.78 4 52859 161301 56077903
Sinus node dysfunction 131.75 12.78 70 52793 4364 56234840
Rash 130.70 12.78 163 52700 492884 55746320
Glossodynia 128.76 12.78 3 52860 152455 56086749
Arthropathy 128.11 12.78 18 52845 200257 56038947
Atrial flutter 127.55 12.78 89 52774 9080 56230124
Therapeutic product effect decreased 127.42 12.78 8 52855 169444 56069760
Drug intolerance 127.15 12.78 45 52818 264773 55974431
Alopecia 124.55 12.78 60 52803 293398 55945806
Arrhythmia 122.80 12.78 158 52705 34925 56204279
Drug ineffective 121.62 12.78 450 52413 918539 55320665
Systemic lupus erythematosus 120.46 12.78 14 52849 180064 56059140
Infusion related reaction 119.98 12.78 25 52838 208906 56030298
Sinusitis 119.05 12.78 21 52842 197560 56041644
Hypokalaemia 110.78 12.78 262 52601 94175 56145029
Lactic acidosis 103.58 12.78 146 52717 35200 56204004
Swelling 103.27 12.78 48 52815 239723 55999481
Multiple organ dysfunction syndrome 98.04 12.78 177 52686 52593 56186611
Long QT syndrome 95.47 12.78 50 52813 3026 56236178
Anaemia 95.26 12.78 499 52364 267012 55972192
Hypersensitivity 94.97 12.78 62 52801 256346 55982858
Cerebral haemorrhage 92.61 12.78 124 52739 28482 56210722
Labelled drug-drug interaction medication error 92.53 12.78 81 52782 11505 56227699
Ventricular arrhythmia 90.03 12.78 50 52813 3404 56235800
Wound 89.86 12.78 12 52851 138792 56100412
Mitral valve incompetence 88.76 12.78 97 52766 18056 56221148
Melaena 87.59 12.78 120 52743 28170 56211034
Nasopharyngitis 86.58 12.78 50 52813 220909 56018295
Fatigue 84.47 12.78 418 52445 788134 55451070
Cardio-respiratory arrest 83.62 12.78 170 52693 55151 56184053
Musculoskeletal stiffness 82.94 12.78 22 52841 155985 56083219
Ventricular extrasystoles 80.86 12.78 73 52790 10797 56228407
Hypoxia 80.72 12.78 165 52698 53732 56185472
Fall 79.57 12.78 591 52272 356919 55882285
Abdominal discomfort 79.40 12.78 86 52777 277188 55962016
Alveolitis 76.05 12.78 41 52822 2632 56236572
Cholestasis 75.65 12.78 109 52754 26804 56212400
Rhabdomyolysis 75.03 12.78 136 52727 40522 56198682
Pericarditis 73.99 12.78 8 52855 108915 56130289
Respiratory failure 73.37 12.78 226 52637 94836 56144368
Atrial tachycardia 71.19 12.78 37 52826 2204 56237000
Infection 68.07 12.78 53 52810 200153 56039051
Maternal exposure during pregnancy 67.26 12.78 48 52815 189505 56049699
Atrioventricular block 67.09 12.78 54 52809 6833 56232371
Cerebral haematoma 65.17 12.78 40 52823 3283 56235921
Renal injury 64.76 12.78 59 52804 8828 56230376
Injection site pain 63.22 12.78 16 52847 117102 56122102
Rectal haemorrhage 62.15 12.78 127 52736 41340 56197864
Pain in extremity 61.63 12.78 116 52747 297315 55941889
Product use issue 61.06 12.78 51 52812 185990 56053214
Toxicity to various agents 60.98 12.78 390 52473 224174 56015030
Haematoma muscle 58.55 12.78 25 52838 952 56238252
Brugada syndrome 58.00 12.78 19 52844 339 56238865
Arterial haemorrhage 57.93 12.78 29 52834 1596 56237608
Cardioversion 57.56 12.78 26 52837 1135 56238069
Atrioventricular block complete 57.07 12.78 51 52812 7443 56231761
Blood thyroid stimulating hormone increased 56.71 12.78 48 52815 6515 56232689
Haemorrhage 56.11 12.78 147 52716 56250 56182954
Hepatocellular injury 55.82 12.78 94 52769 26420 56212784
Discomfort 55.61 12.78 32 52831 141729 56097475
Orthopnoea 55.38 12.78 45 52818 5771 56233433
Infusion site phlebitis 55.26 12.78 13 52850 60 56239144
Therapeutic product effect incomplete 54.39 12.78 16 52847 106015 56133189
Psoriatic arthropathy 54.12 12.78 4 52859 74004 56165200
Lymphatic fistula 53.43 12.78 22 52841 764 56238440
Contraindicated product administered 53.04 12.78 58 52805 186228 56052976
Coronary artery disease 53.03 12.78 100 52763 30696 56208508
Femoral hernia incarcerated 53.02 12.78 22 52841 779 56238425
Migraine 52.73 12.78 9 52854 86788 56152416
Blood loss anaemia 52.63 12.78 51 52812 8246 56230958
Hypoaesthesia 52.62 12.78 34 52829 141457 56097747
Pulmonary hypertension 52.58 12.78 109 52754 35835 56203369
Lung disorder 52.23 12.78 137 52726 52460 56186744
Urticaria 52.15 12.78 36 52827 144640 56094564
Neuromyopathy 51.86 12.78 20 52843 583 56238621
Pulmonary fibrosis 51.70 12.78 97 52766 29661 56209543
Ischaemic stroke 51.46 12.78 71 52792 16771 56222433
Cardioactive drug level increased 51.34 12.78 29 52834 2040 56237164
Stomatitis 50.71 12.78 25 52838 120785 56118419
Acute respiratory distress syndrome 50.57 12.78 81 52782 21845 56217359
Weight increased 49.87 12.78 87 52776 229616 56009588
Drug level increased 49.78 12.78 78 52785 20647 56218557
Treatment failure 49.68 12.78 52 52811 170340 56068864
Faecaloma 49.59 12.78 47 52816 7394 56231810
Arthritis 49.54 12.78 16 52847 99836 56139368
Toxic skin eruption 49.35 12.78 58 52805 11681 56227523
Pancreatic steatosis 49.01 12.78 22 52841 946 56238258
Hyperglobulinaemia 47.77 12.78 8 52855 0 56239204
Exposure during pregnancy 47.73 12.78 35 52828 136307 56102897
Blood cholesterol increased 47.61 12.78 6 52857 72573 56166631
Respiratory distress 47.46 12.78 97 52766 31570 56207634
Haematuria 46.93 12.78 88 52775 26899 56212305
Product dose omission issue 46.80 12.78 75 52788 204678 56034526
Pyrexia 46.35 12.78 219 52644 418554 55820650
Muscle spasms 45.87 12.78 37 52826 137334 56101870
Haemarthrosis 45.76 12.78 31 52832 3013 56236191
Urinary retention 45.68 12.78 89 52774 27985 56211219
Wound infection pseudomonas 45.50 12.78 23 52840 1292 56237912
Dyspnoea 45.25 12.78 794 52069 591783 55647421
Injection site erythema 44.96 12.78 9 52854 77439 56161765
Myocardial infarction 44.48 12.78 189 52674 92681 56146523
Diarrhoea 44.48 12.78 385 52478 638122 55601082
Coagulopathy 44.34 12.78 70 52793 18646 56220558
Pruritus 44.22 12.78 151 52712 316472 55922732
Fibromyalgia 44.22 12.78 3 52860 59600 56179604
Psoriasis 43.99 12.78 16 52847 92676 56146528
Nodal rhythm 43.58 12.78 24 52839 1607 56237597
Septic shock 42.68 12.78 140 52723 60695 56178509
Keratopathy 42.53 12.78 17 52846 546 56238658
Thyrotoxic crisis 42.44 12.78 19 52844 812 56238392
Bundle branch block left 42.04 12.78 40 52823 6322 56232882
Left ventricular dysfunction 41.93 12.78 52 52811 11071 56228133
Corneal deposits 41.38 12.78 14 52849 277 56238927
Back pain 41.20 12.78 102 52761 237068 56002136
Cerebellar syndrome 39.89 12.78 30 52833 3437 56235767
Ill-defined disorder 39.72 12.78 8 52855 68535 56170669
Acute respiratory failure 39.62 12.78 89 52774 30905 56208299
Hepatic cyst 39.26 12.78 34 52829 4759 56234445
Hypomagnesaemia 39.13 12.78 78 52785 24937 56214267
Bradyarrhythmia 39.07 12.78 24 52839 1972 56237232
Ecchymosis 38.37 12.78 48 52815 10308 56228896
Asthma 38.12 12.78 30 52833 112740 56126464
Anuria 38.09 12.78 51 52812 11709 56227495
Cerebellar haematoma 37.91 12.78 14 52849 361 56238843
Tricuspid valve incompetence 37.71 12.78 54 52809 13199 56226005
Listless 37.66 12.78 26 52837 2606 56236598
Extravasation 37.47 12.78 24 52839 2123 56237081
Seroma 37.47 12.78 23 52840 1888 56237316
Respiratory acidosis 37.44 12.78 37 52826 6126 56233078
Extrasystoles 37.22 12.78 33 52830 4766 56234438
Subdural haematoma 36.95 12.78 54 52809 13445 56225759
Depression 36.60 12.78 71 52792 180046 56059158
Pleural effusion 36.42 12.78 168 52695 85312 56153892
Cardiac ablation 36.21 12.78 20 52843 1347 56237857
Injection site reaction 35.92 12.78 4 52859 53243 56185961
Irritable bowel syndrome 35.71 12.78 10 52853 68448 56170756
Device stimulation issue 35.60 12.78 9 52854 59 56239145
Alveolar proteinosis 35.58 12.78 13 52850 325 56238879
Nausea 35.25 12.78 506 52357 763672 55475532
Hypoglycaemia 35.24 12.78 124 52739 55691 56183513
Sudden death 34.69 12.78 44 52819 9581 56229623
Myalgia 34.46 12.78 44 52819 131981 56107223
Inflammatory marker increased 34.13 12.78 35 52828 6055 56233149
Off label use 34.11 12.78 346 52517 555834 55683370
Prothrombin time shortened 33.90 12.78 21 52842 1752 56237452
Reduced facial expression 33.65 12.78 21 52842 1775 56237429
Aortic valve stenosis 33.50 12.78 26 52837 3121 56236083
Agranulocytosis 33.47 12.78 69 52794 22590 56216614
Peripheral swelling 33.39 12.78 111 52752 234615 56004589
Craniocerebral injury 33.26 12.78 24 52839 2580 56236624
Spontaneous haematoma 33.20 12.78 16 52847 810 56238394
Head injury 33.18 12.78 73 52790 24993 56214211
Muscle haemorrhage 32.59 12.78 25 52838 2950 56236254
Cardiac disorder 32.54 12.78 106 52757 45781 56193423
Organising pneumonia 32.35 12.78 32 52831 5303 56233901
Mixed liver injury 32.35 12.78 28 52835 3916 56235288
Pneumonitis 32.13 12.78 83 52780 31481 56207723
Medication error 32.03 12.78 100 52763 42235 56196969
Hepatic failure 32.00 12.78 86 52777 33400 56205804
Right ventricular failure 31.76 12.78 56 52807 16323 56222881
Suicide attempt 31.01 12.78 8 52855 57828 56181376
Gastrooesophageal reflux disease 30.95 12.78 20 52843 83237 56155967
Cornea verticillata 30.92 12.78 9 52854 106 56239098
Arrhythmia supraventricular 30.78 12.78 16 52847 953 56238251
Anticoagulation drug level increased 30.49 12.78 10 52853 179 56239025
Subarachnoid haemorrhage 30.49 12.78 45 52818 11302 56227902
Hepatic enzyme increased 30.30 12.78 73 52790 171311 56067893
Abortion spontaneous 30.25 12.78 3 52860 43750 56195454
Chills 30.24 12.78 31 52832 102573 56136631
Haemorrhagic stroke 30.19 12.78 31 52832 5372 56233832
Iodine overload 29.86 12.78 5 52858 0 56239204
Renal impairment 29.62 12.78 152 52711 80561 56158643
Haemorrhagic diathesis 29.51 12.78 27 52836 4061 56235143
Oliguria 29.50 12.78 38 52825 8402 56230802
Overdose 29.41 12.78 185 52678 105645 56133559
Lower gastrointestinal haemorrhage 29.36 12.78 35 52828 7152 56232052
Ventricular tachyarrhythmia 29.30 12.78 9 52854 129 56239075
Insomnia 29.19 12.78 88 52775 191772 56047432
Rales 29.15 12.78 43 52820 10797 56228407
Pericardial haemorrhage 29.05 12.78 18 52845 1502 56237702
Glomerular filtration rate decreased 29.05 12.78 46 52817 12283 56226921
Acute hepatic failure 28.75 12.78 54 52809 16524 56222680
Mediastinal haematoma 28.31 12.78 8 52855 84 56239120
Knee arthroplasty 28.21 12.78 4 52859 44255 56194949
General physical health deterioration 28.03 12.78 263 52600 169747 56069457
White blood cell count decreased 27.97 12.78 47 52816 125943 56113261
Hypervolaemia 27.37 12.78 70 52793 26388 56212816
Intentional product use issue 27.33 12.78 32 52831 99701 56139503
Oedema peripheral 27.28 12.78 263 52600 170991 56068213
Myxoedema 27.27 12.78 8 52855 97 56239107
Herpes zoster 27.17 12.78 19 52844 75870 56163334
Goitre congenital 26.92 12.78 5 52858 4 56239200
Heparin-induced thrombocytopenia 26.91 12.78 26 52837 4188 56235016
Hepatitis acute 26.69 12.78 36 52827 8321 56230883
Subcutaneous haematoma 26.00 12.78 17 52846 1557 56237647
Cardiac failure chronic 25.79 12.78 25 52838 4042 56235162
Diverticulum intestinal 25.72 12.78 31 52832 6409 56232795
Nodal arrhythmia 25.59 12.78 15 52848 1132 56238072
Shock 25.14 12.78 60 52803 21668 56217536
Myopathy 25.06 12.78 38 52825 9774 56229430
Gastrointestinal disorder 25.06 12.78 42 52821 112660 56126544
Oesophageal squamous cell carcinoma 25.00 12.78 8 52855 132 56239072
Acute generalised exanthematous pustulosis 24.90 12.78 38 52825 9831 56229373
Drug hypersensitivity 24.82 12.78 154 52709 275051 55964153
Asthenia 24.80 12.78 456 52407 342517 55896687
Encephalopathy 24.50 12.78 81 52782 35244 56203960
Atrioventricular block first degree 24.50 12.78 31 52832 6734 56232470
Device capturing issue 24.48 12.78 6 52857 34 56239170
Coronary artery bypass 24.45 12.78 19 52844 2284 56236920
Central nervous system injury 24.41 12.78 8 52855 143 56239061
Pericardial effusion 24.18 12.78 68 52795 27107 56212097
Sinoatrial block 24.13 12.78 13 52850 833 56238371
Eosinophilia 23.83 12.78 56 52807 20021 56219183
Abdominal pain upper 23.55 12.78 87 52776 178226 56060978
Foreign body 23.51 12.78 18 52845 2118 56237086
Abdominal wall haematoma 23.42 12.78 20 52843 2747 56236457
Injection site bruising 23.38 12.78 4 52859 38517 56200687
Cardiac arrest neonatal 23.21 12.78 7 52856 94 56239110
Thrombocytopenia 23.08 12.78 212 52651 136012 56103192
Pulmonary alveolar haemorrhage 22.99 12.78 24 52839 4240 56234964
Electrocardiogram QRS complex prolonged 22.96 12.78 27 52836 5440 56233764
Blister 22.92 12.78 42 52821 108845 56130359
Transaminases increased 22.73 12.78 69 52794 28701 56210503
Hypoxic-ischaemic encephalopathy 22.70 12.78 23 52840 3922 56235282
Intra-abdominal haematoma 22.70 12.78 16 52847 1658 56237546
Liver function test abnormal 22.67 12.78 94 52769 45577 56193627
Musculoskeletal pain 22.27 12.78 26 52837 81126 56158078
Splenic haemorrhage 22.16 12.78 8 52855 193 56239011
Cardiac failure acute 22.15 12.78 34 52829 8839 56230365
Thyroxine increased 22.13 12.78 11 52852 596 56238608
Potentiating drug interaction 22.12 12.78 23 52840 4043 56235161
Retroperitoneal haemorrhage 22.11 12.78 19 52844 2631 56236573
Hepatic cytolysis 22.07 12.78 38 52825 10868 56228336
Constipation 22.05 12.78 106 52757 201837 56037367
Feeling abnormal 21.99 12.78 59 52804 133543 56105661
Splenic injury 21.90 12.78 8 52855 200 56239004
Presyncope 21.78 12.78 63 52800 25519 56213685
Acute pulmonary oedema 21.68 12.78 31 52832 7566 56231638
Bone pain 21.64 12.78 10 52853 50175 56189029
Retroperitoneal haematoma 21.61 12.78 19 52844 2714 56236490
Hypochromasia 21.34 12.78 9 52854 332 56238872
Prerenal failure 21.23 12.78 15 52848 1560 56237644
Paraesthesia 21.21 12.78 58 52805 130456 56108748
Lower respiratory tract infection 21.00 12.78 48 52815 114746 56124458
Influenza like illness 20.89 12.78 16 52847 60972 56178232
Cyanosis 20.88 12.78 46 52817 15764 56223440
Type 2 diabetes mellitus 20.74 12.78 9 52854 46853 56192351
Aortic arteriosclerosis 20.71 12.78 26 52837 5604 56233600
Pulmonary oedema 20.66 12.78 99 52764 51044 56188160
Cardioactive drug level above therapeutic 20.53 12.78 7 52856 142 56239062
Cardiac tamponade 20.51 12.78 23 52840 4403 56234801
Upper respiratory tract infection 20.48 12.78 22 52841 71266 56167938
Device pacing issue 20.43 12.78 6 52857 73 56239131
Drug-induced liver injury 20.42 12.78 75 52788 34387 56204817
Haemorrhage intracranial 20.22 12.78 40 52823 12715 56226489
Local anaesthetic systemic toxicity 20.16 12.78 11 52852 723 56238481
Neck pain 20.02 12.78 17 52846 61538 56177666
Palpitations 19.97 12.78 161 52702 99511 56139693
C-reactive protein abnormal 19.91 12.78 5 52858 36804 56202400
Injection site swelling 19.88 12.78 8 52855 43570 56195634
Red blood cell sedimentation rate increased 19.76 12.78 5 52858 36618 56202586
Blood creatinine increased 19.73 12.78 136 52727 80055 56159149
Wound dehiscence 19.73 12.78 23 52840 4592 56234612
Osteoarthritis 19.69 12.78 28 52835 80268 56158936
Anti-thyroid antibody positive 19.56 12.78 9 52854 410 56238794
Memory impairment 19.48 12.78 32 52831 86525 56152679
Dyschromatopsia 19.42 12.78 9 52854 417 56238787
Propionibacterium infection 19.37 12.78 5 52858 36 56239168
Hepatitis fulminant 19.03 12.78 19 52844 3185 56236019
Pelvic fracture 19.00 12.78 38 52825 12175 56227029
Escherichia infection 18.92 12.78 37 52826 11662 56227542
Subdural haemorrhage 18.91 12.78 18 52845 2846 56236358
Prothrombin time prolonged 18.90 12.78 32 52831 9028 56230176
Activated partial thromboplastin time prolonged 18.90 12.78 27 52836 6585 56232619
Oropharyngeal pain 18.83 12.78 31 52832 83757 56155447
Thyroiditis acute 18.75 12.78 6 52857 99 56239105
Optic disc haemorrhage 18.69 12.78 6 52857 100 56239104
Thyroxine free increased 18.60 12.78 11 52852 844 56238360
Anisocytosis 18.56 12.78 10 52853 641 56238563
Throat irritation 18.55 12.78 4 52859 32679 56206525
Hypoglycaemic seizure 18.52 12.78 9 52854 464 56238740
Intentional overdose 18.50 12.78 22 52841 68095 56171109
Altered visual depth perception 18.48 12.78 8 52855 315 56238889
Adverse event 18.37 12.78 15 52848 55361 56183843
Conduction disorder 18.29 12.78 13 52850 1365 56237839
Prescription drug used without a prescription 18.18 12.78 15 52848 1965 56237239
Fear 18.15 12.78 42 52821 14866 56224338
Ischaemic hepatitis 18.15 12.78 15 52848 1970 56237234
Night sweats 18.10 12.78 8 52855 41205 56197999
Thyroglobulin increased 18.10 12.78 5 52858 48 56239156
Anhedonia 18.07 12.78 33 52830 9881 56229323
Myocardial ischaemia 18.02 12.78 37 52826 12079 56227125
Chorea 18.00 12.78 13 52850 1399 56237805
Electrocardiogram PR prolongation 17.97 12.78 10 52853 683 56238521
Pharyngeal haematoma 17.92 12.78 5 52858 50 56239154
Febrile neutropenia 17.83 12.78 46 52817 105499 56133705
Congenital hypothyroidism 17.54 12.78 7 52856 224 56238980
Neovascular age-related macular degeneration 17.51 12.78 7 52856 225 56238979
Circulatory collapse 17.48 12.78 51 52812 20752 56218452
Haemorrhagic thyroid cyst 17.46 12.78 4 52859 16 56239188
Drug level above therapeutic 17.42 12.78 21 52842 4341 56234863
Chronic kidney disease 17.42 12.78 82 52781 41974 56197230
Ear infection 17.42 12.78 4 52859 31291 56207913
Petechiae 17.29 12.78 38 52825 13001 56226203
Ear pain 17.09 12.78 4 52859 30886 56208318
Head discomfort 17.06 12.78 36 52827 11978 56227226
Tri-iodothyronine increased 16.93 12.78 6 52857 137 56239067
Ataxia 16.90 12.78 40 52823 14363 56224841
Compensatory sweating 16.74 12.78 4 52859 20 56239184
Electrocardiogram T wave inversion 16.58 12.78 18 52845 3325 56235879
Apathy 16.47 12.78 28 52835 7926 56231278
Swelling face 16.45 12.78 17 52846 56052 56183152
Secondary hyperthyroidism 16.42 12.78 4 52859 22 56239182
Death 16.36 12.78 428 52435 340998 55898206
Dyspnoea at rest 16.29 12.78 19 52844 3794 56235410
Disease progression 16.16 12.78 48 52815 105125 56134079
Electrocardiogram QRS complex shortened 16.15 12.78 8 52855 430 56238774
Eosinophilic pneumonia 16.14 12.78 14 52849 1963 56237241
Impaired healing 16.13 12.78 36 52827 86805 56152399
Drug clearance decreased 16.13 12.78 12 52851 1352 56237852
Tubulointerstitial nephritis 16.12 12.78 43 52820 16622 56222582
Anaphylactic reaction 16.08 12.78 19 52844 58976 56180228
Cardiovascular insufficiency 16.07 12.78 12 52851 1360 56237844
Ejection fraction decreased 16.06 12.78 48 52815 19793 56219411
Kidney malrotation 15.99 12.78 4 52859 25 56239179
Gastroenteritis aeromonas 15.99 12.78 4 52859 25 56239179
Neutrophil count decreased 15.91 12.78 14 52849 49808 56189396
Low cardiac output syndrome 15.84 12.78 7 52856 290 56238914
Apnoea 15.67 12.78 26 52837 7216 56231988
Therapeutic response decreased 15.47 12.78 16 52847 52742 56186462
Endovenous ablation 15.38 12.78 3 52860 4 56239200
Lip swelling 15.36 12.78 3 52860 26269 56212935
Infective pericardial effusion 15.35 12.78 4 52859 30 56239174
Suicidal ideation 15.31 12.78 19 52844 57723 56181481
Electrocardiogram U wave present 15.07 12.78 5 52858 93 56239111
Optic atrophy 15.06 12.78 11 52852 1205 56237999
Splenic rupture 14.97 12.78 11 52852 1216 56237988
Coagulation test abnormal 14.95 12.78 9 52854 713 56238491
Atrioventricular block second degree 14.94 12.78 18 52845 3718 56235486
Sedation 14.94 12.78 7 52856 34847 56204357
Blood pressure increased 14.81 12.78 78 52785 145098 56094106
Congestive hepatopathy 14.79 12.78 15 52848 2561 56236643
Hyperchloraemia 14.78 12.78 9 52854 728 56238476
Cutaneous lupus erythematosus 14.75 12.78 15 52848 2569 56236635
Cardiovascular disorder 14.74 12.78 32 52831 10857 56228347
Renal function test abnormal 14.74 12.78 16 52847 2955 56236249
Oesophageal adenocarcinoma recurrent 14.71 12.78 4 52859 36 56239168
Illness 14.69 12.78 7 52856 34504 56204700
Supraventricular tachycardia 14.62 12.78 36 52827 13255 56225949
Therapy non-responder 14.45 12.78 22 52841 61333 56177871
Extradural haematoma 14.44 12.78 12 52851 1588 56237616
Electrocardiogram T wave abnormal 14.40 12.78 14 52849 2272 56236932
Paroxysmal arrhythmia 14.33 12.78 4 52859 40 56239164
Dehydration 14.32 12.78 219 52644 158606 56080598
Atrioventricular dissociation 14.26 12.78 6 52857 220 56238984
Optic neuropathy 14.26 12.78 13 52850 1947 56237257
Lung consolidation 14.20 12.78 18 52845 3916 56235288
Hypocoagulable state 14.20 12.78 10 52853 1035 56238169
Erythema 14.17 12.78 87 52776 155852 56083352
Electrocardiogram T wave alternans 14.16 12.78 4 52859 42 56239162
Photosensitivity reaction 14.10 12.78 36 52827 13557 56225647
Oral mucosa haematoma 14.02 12.78 3 52860 8 56239196
Hypovolaemic shock 13.99 12.78 21 52842 5352 56233852
Lung infiltration 13.85 12.78 36 52827 13702 56225502
Left ventricular failure 13.69 12.78 20 52843 4976 56234228
Haemoglobin decreased 13.69 12.78 189 52674 133948 56105256
Cerebrovascular accident 13.66 12.78 148 52715 99122 56140082
Sopor 13.65 12.78 47 52816 20875 56218329
Pulseless electrical activity 13.60 12.78 24 52839 7000 56232204
Eosinophilic pleural effusion 13.60 12.78 4 52859 49 56239155
Eructation 13.51 12.78 25 52838 7563 56231641
Cardiomegaly 13.48 12.78 40 52823 16427 56222777
Goitre 13.41 12.78 21 52842 5552 56233652
Foot deformity 13.35 12.78 3 52860 23822 56215382
Eosinophilia myalgia syndrome 13.30 12.78 3 52860 11 56239193
Aortic valve incompetence 13.30 12.78 21 52842 5591 56233613
Groin pain 13.28 12.78 28 52835 9312 56229892
Monoclonal gammopathy 13.24 12.78 8 52855 638 56238566
Bullous haemorrhagic dermatosis 13.17 12.78 4 52859 55 56239149
Respiratory alkalosis 13.11 12.78 14 52849 2537 56236667
Hepatitis toxic 13.10 12.78 15 52848 2937 56236267
Thyroiditis chronic 13.10 12.78 3 52860 12 56239192
Toxic epidermal necrolysis 13.08 12.78 48 52815 21994 56217210
Haemodynamic instability 13.06 12.78 26 52837 8303 56230901
Lymphocyte count decreased 12.95 12.78 5 52858 27934 56211270
Pancreatitis 12.85 12.78 14 52849 45066 56194138
Concomitant disease aggravated 12.85 12.78 26 52837 8400 56230804
Loss of consciousness 12.80 12.78 158 52705 109191 56130013
Arterial insufficiency 12.80 12.78 5 52858 151 56239053

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperthyroidism 1798.39 11.50 722 74358 8909 31613355
Pulmonary toxicity 692.88 11.50 310 74770 5067 31617197
Ventricular tachycardia 688.40 11.50 517 74563 23184 31599080
Atrial fibrillation 617.57 11.50 1025 74055 112758 31509506
Drug interaction 541.19 11.50 1384 73696 207159 31415105
Bradycardia 476.72 11.50 697 74383 68630 31553634
Interstitial lung disease 468.82 11.50 649 74431 60754 31561510
Cardiac failure 466.75 11.50 775 74305 85178 31537086
Thyroiditis 366.52 11.50 151 74929 1992 31620272
Hypothyroidism 337.02 11.50 304 74776 17643 31604621
Electrocardiogram QT prolonged 331.80 11.50 429 74651 37558 31584706
Torsade de pointes 318.80 11.50 200 74880 6650 31615614
Pulmonary fibrosis 271.87 11.50 261 74819 16399 31605865
Cardiogenic shock 262.75 11.50 294 74786 22114 31600150
Ventricular fibrillation 260.90 11.50 270 74810 18578 31603686
Thyrotoxic crisis 196.79 11.50 61 75019 321 31621943
International normalised ratio increased 180.29 11.50 357 74723 44866 31577398
Acute kidney injury 174.28 11.50 1195 73885 278519 31343745
Cardiac failure congestive 172.78 11.50 495 74585 78892 31543372
Pulmonary alveolar haemorrhage 151.99 11.50 127 74953 6639 31615625
Hypotension 149.80 11.50 911 74169 203707 31418557
Ejection fraction decreased 146.04 11.50 193 74887 17241 31605023
Multiple organ dysfunction syndrome 145.21 11.50 422 74658 67781 31554483
Ventricular arrhythmia 142.52 11.50 107 74973 4784 31617480
Appendicolith 140.11 11.50 113 74967 5618 31616646
Completed suicide 125.71 11.50 31 75049 91483 31530781
Atrial flutter 125.48 11.50 164 74916 14491 31607773
Pyrexia 121.22 11.50 346 74734 303494 31318770
Blood thyroid stimulating hormone increased 108.93 11.50 80 75000 3457 31618807
Lung disorder 104.21 11.50 234 74846 32078 31590186
Cardiac failure chronic 101.70 11.50 105 74975 7198 31615066
Acute respiratory distress syndrome 100.49 11.50 196 74884 24344 31597920
Sinus bradycardia 96.92 11.50 131 74949 11956 31610308
Appendicitis 96.13 11.50 127 74953 11338 31610926
Arthralgia 96.07 11.50 131 74949 151293 31470971
Cardiac arrest 93.29 11.50 438 74642 88624 31533640
Thyroid disorder 93.06 11.50 68 75012 2915 31619349
Myxoedema coma 92.49 11.50 32 75048 250 31622014
Arrhythmia 91.91 11.50 226 74854 32851 31589413
Febrile neutropenia 91.69 11.50 92 74988 121757 31500507
Atrioventricular block 90.92 11.50 99 74981 7216 31615048
Syncope 88.54 11.50 418 74662 84764 31537500
Organising pneumonia 87.36 11.50 85 74995 5425 31616839
Renal failure 86.17 11.50 543 74537 122787 31499477
Atrial tachycardia 84.43 11.50 55 75025 1952 31620312
Headache 79.97 11.50 200 74880 183452 31438812
Drug abuse 77.27 11.50 57 75023 87701 31534563
Diarrhoea 72.19 11.50 514 74566 351895 31270369
Seizure 72.02 11.50 78 75002 99690 31522574
N-terminal prohormone brain natriuretic peptide increased 70.89 11.50 51 75029 2133 31620131
Corneal deposits 70.45 11.50 24 75056 178 31622086
Cornea verticillata 68.96 11.50 17 75063 29 31622235
Stress 68.84 11.50 170 74910 24771 31597493
Hyperkalaemia 66.99 11.50 316 74764 64035 31558229
Cardiac failure acute 66.85 11.50 98 74982 9643 31612621
Pericardial haemorrhage 66.45 11.50 56 75024 2961 31619303
Hyperglobulinaemia 65.62 11.50 13 75067 0 31622264
Palpitations 65.07 11.50 205 74875 34378 31587886
Dyspnoea 64.80 11.50 1157 73923 342322 31279942
Infusion site phlebitis 64.76 11.50 17 75063 42 31622222
Product dose omission issue 62.34 11.50 96 74984 105490 31516774
Suicidal ideation 61.70 11.50 7 75073 36399 31585865
Venous pressure jugular increased 61.31 11.50 32 75048 743 31621521
Shock haemorrhagic 60.80 11.50 96 74984 10081 31612183
Rheumatoid arthritis 58.63 11.50 20 75060 47789 31574475
Anticoagulation drug level increased 57.80 11.50 27 75053 489 31621775
Cerebral haematoma 57.28 11.50 61 75019 4334 31617930
Atrioventricular block complete 57.09 11.50 85 74995 8480 31613784
Nasopharyngitis 57.07 11.50 40 75040 63205 31559059
Ventricular extrasystoles 55.69 11.50 97 74983 11045 31611219
Dyspnoea exertional 54.60 11.50 209 74871 38628 31583636
Pain in extremity 54.14 11.50 122 74958 116081 31506183
Haematuria 53.83 11.50 235 74845 46079 31576185
Pericardial effusion 53.80 11.50 145 74935 22278 31599986
Labelled drug-drug interaction medication error 53.71 11.50 105 74975 13058 31609206
Malignant neoplasm progression 53.49 11.50 65 75015 78933 31543331
Neutropenia 53.48 11.50 163 74917 140201 31482063
BRASH syndrome 52.73 11.50 22 75058 300 31621964
Neutrophil count decreased 52.56 11.50 22 75058 46372 31575892
Anhedonia 51.25 11.50 75 75005 7367 31614897
Rash 50.37 11.50 276 74804 201210 31421054
Gastrointestinal haemorrhage 47.73 11.50 347 74733 82202 31540062
Sinus node dysfunction 47.55 11.50 52 75028 3808 31618456
Cardioactive drug level increased 47.46 11.50 36 75044 1634 31620630
Asthma 47.01 11.50 21 75059 42590 31579674
Jugular vein distension 46.34 11.50 25 75055 622 31621642
Tachycardia induced cardiomyopathy 45.40 11.50 15 75065 100 31622164
Thyroxine increased 44.80 11.50 14 75066 76 31622188
Exercise tolerance decreased 44.40 11.50 55 75025 4603 31617661
Atrioventricular block first degree 44.20 11.50 61 75019 5676 31616588
Thyroxine free increased 43.57 11.50 18 75062 239 31622025
Phlebitis 42.88 11.50 48 75032 3607 31618657
Drug-induced liver injury 42.72 11.50 141 74939 24222 31598042
Hyponatraemia 42.53 11.50 310 74770 73489 31548775
Rectal haemorrhage 42.02 11.50 184 74896 36120 31586144
Keratopathy 41.84 11.50 21 75059 448 31621816
Fatigue 41.35 11.50 553 74527 334653 31287611
Goitre 40.80 11.50 32 75048 1527 31620737
Muscle spasms 40.41 11.50 62 75018 68256 31554008
Coronary artery bypass 39.98 11.50 53 75027 4746 31617518
Acute respiratory failure 39.44 11.50 151 74929 27904 31594360
Haematoma 39.06 11.50 136 74944 24003 31598261
Off label use 38.91 11.50 584 74496 346690 31275574
Musculoskeletal stiffness 38.80 11.50 25 75055 41300 31580964
Left ventricular failure 38.63 11.50 52 75028 4725 31617539
Injection site pain 38.31 11.50 17 75063 34617 31587647
Pneumonitis 38.29 11.50 159 74921 30493 31591771
Death 38.16 11.50 613 74467 359956 31262308
Cardiac tamponade 37.78 11.50 52 75028 4827 31617437
Therapeutic product effect incomplete 37.64 11.50 29 75051 43667 31578597
Renal injury 37.50 11.50 80 75000 10585 31611679
Ascites 37.39 11.50 194 74886 40819 31581445
Rhabdomyolysis 37.16 11.50 268 74812 63313 31558951
Subdural haematoma 37.10 11.50 114 74966 18857 31603407
Orthopnoea 37.08 11.50 51 75029 4730 31617534
Drug dependence 36.65 11.50 5 75075 22574 31599690
Deep vein thrombosis 36.03 11.50 55 75025 60681 31561583
Melaena 35.91 11.50 163 74917 32491 31589773
Pain 35.88 11.50 277 74803 186482 31435782
Hepatocellular injury 35.40 11.50 122 74958 21422 31600842
Pulmonary embolism 35.39 11.50 89 74991 81557 31540707
White blood cell count decreased 35.06 11.50 99 74981 87299 31534965
Back pain 34.93 11.50 137 74943 109276 31512988
Insomnia 34.77 11.50 112 74968 94724 31527540
Cytomegalovirus infection 34.62 11.50 8 75072 24699 31597565
Aggression 34.41 11.50 23 75057 37268 31584996
Cardioversion 34.10 11.50 23 75057 866 31621398
Renal impairment 33.95 11.50 333 74747 86016 31536248
Tachyarrhythmia 33.73 11.50 40 75040 3199 31619065
Coagulopathy 33.22 11.50 108 74972 18407 31603857
Infusion related reaction 33.09 11.50 39 75041 48016 31574248
Potentiating drug interaction 32.98 11.50 47 75033 4506 31617758
Myalgia 32.12 11.50 86 74994 77172 31545092
Sinusitis 32.06 11.50 24 75056 36672 31585592
Hypertransaminasaemia 32.02 11.50 45 75035 4259 31618005
Crepitations 31.89 11.50 37 75043 2891 31619373
Nodal rhythm 31.84 11.50 26 75054 1315 31620949
Rales 31.77 11.50 66 75014 8573 31613691
Platelet count decreased 31.72 11.50 144 74936 110291 31511973
Stomatitis 31.71 11.50 28 75052 39410 31582854
Asthenia 31.52 11.50 725 74355 224030 31398234
Pacemaker generated rhythm 31.16 11.50 10 75070 60 31622204
Gastrooesophageal reflux disease 31.10 11.50 21 75059 33850 31588414
Intentional product use issue 30.92 11.50 43 75037 49304 31572960
Nodal arrhythmia 30.92 11.50 21 75059 800 31621464
Fear 30.77 11.50 71 75009 9903 31612361
Gravitational oedema 30.75 11.50 19 75061 614 31621650
Mitochondrial aspartate aminotransferase increased 30.50 11.50 7 75073 7 31622257
Pleural effusion 30.47 11.50 291 74789 74629 31547635
Colitis ulcerative 30.32 11.50 4 75076 18525 31603739
Bundle branch block left 30.16 11.50 50 75030 5468 31616796
Disease progression 29.69 11.50 112 74968 90352 31531912
Respiratory failure 29.68 11.50 369 74711 101080 31521184
Spontaneous haematoma 29.57 11.50 17 75063 480 31621784
Long QT syndrome 29.47 11.50 32 75048 2324 31619940
Nausea 29.46 11.50 533 74547 307414 31314850
Prothrombin time prolonged 29.37 11.50 66 75014 9046 31613218
Anticoagulation drug level above therapeutic 29.29 11.50 29 75051 1890 31620374
Activated partial thromboplastin time prolonged 29.27 11.50 62 75018 8163 31614101
Optic neuropathy 29.06 11.50 28 75052 1765 31620499
Chills 29.00 11.50 85 74995 74065 31548199
Prostate cancer 28.69 11.50 28 75052 37573 31584691
Cerebral haemorrhage 28.39 11.50 153 74927 32659 31589605
Traumatic lung injury 28.09 11.50 23 75057 1168 31621096
Angiodysplasia 28.00 11.50 17 75063 532 31621732
Hypertension 27.99 11.50 183 74897 127917 31494347
Herpes zoster 27.85 11.50 21 75059 31972 31590292
Blood pressure increased 27.84 11.50 96 74984 79537 31542727
Device inappropriate shock delivery 27.78 11.50 8 75072 31 31622233
Intraocular haematoma 27.68 11.50 7 75073 14 31622250
Heparin-induced thrombocytopenia 27.57 11.50 47 75033 5259 31617005
Depression 27.54 11.50 116 74964 90699 31531565
Low cardiac output syndrome 27.50 11.50 17 75063 550 31621714
Blood loss anaemia 27.25 11.50 58 75022 7661 31614603
Psoriasis 27.05 11.50 43 75037 46676 31575588
Blood pressure fluctuation 27.03 11.50 10 75070 22726 31599538
Mucosal inflammation 27.01 11.50 25 75055 34402 31587862
Hypoaesthesia 26.73 11.50 58 75022 55964 31566300
Presyncope 26.64 11.50 96 74984 17232 31605032
Optic ischaemic neuropathy 26.52 11.50 28 75052 1969 31620295
Myoclonus 26.36 11.50 83 74997 13907 31608357
Injury 26.01 11.50 104 74976 19605 31602659
Influenza like illness 25.83 11.50 14 75066 25423 31596841
Xyphoid retraction 25.60 11.50 11 75069 162 31622102
Cardiac output decreased 25.58 11.50 19 75061 835 31621429
Hydrops foetalis 25.36 11.50 15 75065 447 31621817
Halo vision 25.36 11.50 11 75069 166 31622098
Accessory cardiac pathway 25.24 11.50 5 75075 0 31622264
Myelosuppression 24.95 11.50 3 75077 14917 31607347
Sedation 24.92 11.50 7 75073 18958 31603306
Acute pulmonary oedema 24.79 11.50 53 75027 7023 31615241
Diaphragmatic paralysis 24.75 11.50 15 75065 468 31621796
Pancreatitis 24.66 11.50 29 75051 35742 31586522
Pruritus 24.31 11.50 185 74895 124982 31497282
Haemodynamic instability 24.24 11.50 59 75021 8516 31613748
Haemothorax 24.20 11.50 36 75044 3588 31618676
Platelet distribution width increased 24.19 11.50 10 75070 133 31622131
Thyroid function test abnormal 24.18 11.50 17 75063 685 31621579
Dissociation 24.17 11.50 22 75058 1290 31620974
Antiacetylcholine receptor antibody positive 24.13 11.50 8 75072 54 31622210
Joint swelling 24.13 11.50 57 75023 53374 31568890
Cardiac murmur 24.09 11.50 51 75029 6711 31615553
Urinary tract infection 24.04 11.50 97 74983 76772 31545492
Hypersensitivity 23.97 11.50 61 75019 55682 31566582
International normalised ratio abnormal 23.92 11.50 33 75047 3069 31619195
Glomerular filtration rate decreased 23.85 11.50 72 75008 11793 31610471
Therapeutic product effect decreased 23.60 11.50 24 75056 31598 31590666
Fall 23.55 11.50 592 74488 185497 31436767
Migraine 23.35 11.50 3 75077 14177 31608087
Puncture site haematoma 23.29 11.50 10 75070 147 31622117
Blood glucose increased 23.18 11.50 71 75009 61012 31561252
Periorbital haemorrhage 22.98 11.50 9 75071 103 31622161
Toxic goitre 22.90 11.50 5 75075 3 31622261
Tachycardia foetal 22.74 11.50 13 75067 363 31621901
Left atrial enlargement 22.48 11.50 17 75063 768 31621496
Nephrolithiasis 22.47 11.50 19 75061 27320 31594944
Femoral artery aneurysm 22.41 11.50 10 75070 162 31622102
Atrial thrombosis 22.41 11.50 26 75054 2031 31620233
Blood phosphorus increased 22.37 11.50 39 75041 4443 31617821
Urine iodine increased 22.31 11.50 5 75075 4 31622260
Blood creatinine increased 22.30 11.50 315 74765 88763 31533501
Arteriosclerotic gangrene 22.23 11.50 8 75072 71 31622193
Plasma cell myeloma 21.96 11.50 65 75015 56466 31565798
Cardiorenal syndrome 21.93 11.50 16 75064 684 31621580
Cholestatic liver injury 21.80 11.50 25 75055 1929 31620335
Iodine uptake abnormal 21.79 11.50 5 75075 5 31622259
Cardiac ventricular disorder 21.78 11.50 11 75069 238 31622026
Urticaria 21.72 11.50 67 75013 57450 31564814
Gastrointestinal angiodysplasia 21.64 11.50 15 75065 591 31621673
Lymphocyte count decreased 21.51 11.50 11 75069 20638 31601626
Neonatal pneumonia 21.36 11.50 9 75071 126 31622138
Device pacing issue 21.31 11.50 6 75074 21 31622243
Diabetes mellitus 21.19 11.50 43 75037 42513 31579751
Ischaemic stroke 21.16 11.50 88 74992 16883 31605381
Neuropathy peripheral 20.90 11.50 100 74980 75549 31546715
Hyperglycaemia 20.71 11.50 34 75046 36442 31585822
Orthostatic hypertension 20.63 11.50 11 75069 267 31621997
Oedema peripheral 20.55 11.50 370 74710 109469 31512795
Subarachnoid haemorrhage 20.34 11.50 62 75018 10209 31612055
Glomerular filtration rate 20.17 11.50 8 75072 95 31622169
Anuria 20.15 11.50 60 75020 9754 31612510
Cardio-respiratory arrest 20.08 11.50 199 74881 51527 31570737
Sinoatrial block 20.04 11.50 13 75067 458 31621806
Left ventricular dysfunction 19.97 11.50 58 75022 9299 31612965
Neonatal hypotension 19.94 11.50 9 75071 150 31622114
Lupus pneumonitis 19.87 11.50 7 75073 58 31622206
General physical health deterioration 19.80 11.50 378 74702 113057 31509207
Bundle branch block 19.68 11.50 16 75064 804 31621460
Papilloedema 19.67 11.50 27 75053 2499 31619765
Anaemia macrocytic 19.64 11.50 29 75051 2871 31619393
Drug withdrawal syndrome 19.51 11.50 10 75070 18740 31603524
Respiratory distress 19.34 11.50 141 74939 33412 31588852
Ischaemic cardiomyopathy 19.32 11.50 43 75037 5854 31616410
Dyspnoea at rest 19.31 11.50 32 75048 3499 31618765
Supraventricular tachycardia 19.28 11.50 61 75019 10246 31612018
Lymphoid tissue hyperplasia 19.27 11.50 7 75073 64 31622200
Conjunctival haemorrhage 19.26 11.50 28 75052 2734 31619530
Swelling 19.24 11.50 37 75043 37321 31584943
Normocytic anaemia 19.22 11.50 24 75056 2025 31620239
Eosinophilia 19.15 11.50 107 74973 23146 31599118
Upper respiratory tract infection 19.07 11.50 25 75055 29397 31592867
Supine hypertension 19.03 11.50 11 75069 314 31621950
Aerophagia 18.99 11.50 6 75074 34 31622230
Depressed mood 18.85 11.50 9 75071 17566 31604698
Product use issue 18.79 11.50 70 75010 56689 31565575
Alopecia 18.77 11.50 13 75067 20682 31601582
Pulmonary oedema 18.65 11.50 174 74906 44328 31577936
Porphyria acute 18.56 11.50 11 75069 329 31621935
Drug resistance 18.43 11.50 17 75063 23436 31598828
Pseudolymphoma 18.15 11.50 13 75067 540 31621724
Foetal exposure during pregnancy 18.14 11.50 44 75036 40832 31581432
Withdrawal syndrome 18.08 11.50 3 75077 11714 31610550
Coma uraemic 18.03 11.50 6 75074 41 31622223
Iodine overload 17.96 11.50 4 75076 3 31622261
Osteonecrosis of jaw 17.92 11.50 9 75071 17062 31605202
Tumour lysis syndrome 17.90 11.50 7 75073 15378 31606886
Abnormal behaviour 17.88 11.50 18 75062 23810 31598454
Dyspepsia 17.87 11.50 31 75049 32522 31589742
Ecchymosis 17.83 11.50 44 75036 6406 31615858
Rhinorrhoea 17.71 11.50 17 75063 22995 31599269
Musculoskeletal pain 17.69 11.50 27 75053 29801 31592463
Accidental exposure to product 17.62 11.50 3 75077 11492 31610772
Blood thyroid stimulating hormone decreased 17.57 11.50 22 75058 1861 31620403
Neuroleptic malignant syndrome 17.55 11.50 9 75071 16860 31605404
Irritability 17.51 11.50 17 75063 22872 31599392
Oesophageal infection 17.47 11.50 10 75070 280 31621984
Secondary hyperthyroidism 17.43 11.50 4 75076 4 31622260
Pemphigoid 17.39 11.50 51 75029 8220 31614044
Loss of personal independence in daily activities 17.37 11.50 25 75055 28263 31594001
Lower respiratory tract infection 17.29 11.50 25 75055 28212 31594052
Orthostatic hypotension 17.29 11.50 107 74973 24012 31598252
Haemoptysis 17.27 11.50 133 74947 32056 31590208
Oropharyngeal pain 17.27 11.50 30 75050 31453 31590811
Cholestasis 17.20 11.50 110 74970 24965 31597299
Influenza 17.19 11.50 51 75029 44274 31577990
Muscle haemorrhage 17.00 11.50 30 75050 3450 31618814
Vascular purpura 16.89 11.50 19 75061 1435 31620829
Abdominal discomfort 16.80 11.50 64 75016 51503 31570761
Serotonin syndrome 16.76 11.50 12 75068 18761 31603503
Electrocardiogram PR prolongation 16.75 11.50 14 75066 732 31621532
Systemic inflammatory response syndrome 16.71 11.50 42 75038 6183 31616081
Bladder cancer 16.64 11.50 7 75073 14718 31607546
COVID-19 16.62 11.50 70 75010 54751 31567513
Decreased appetite 16.62 11.50 259 74821 152958 31469306
Cardiac pacemaker insertion 16.61 11.50 26 75054 2709 31619555
Ilium fracture 16.55 11.50 7 75073 99 31622165
Scrotal haematocoele 16.51 11.50 5 75075 24 31622240
Ejection fraction abnormal 16.44 11.50 15 75065 882 31621382
Haemorrhage intracranial 16.34 11.50 75 75005 15013 31607251
Thyroiditis acute 16.30 11.50 7 75073 103 31622161
Colitis 16.23 11.50 35 75045 33852 31588412
Product quality issue 16.17 11.50 9 75071 16102 31606162
Dry skin 16.16 11.50 22 75058 25459 31596805
Injection site erythema 16.15 11.50 7 75073 14455 31607809
Hospitalisation 16.11 11.50 62 75018 49745 31572519
Cardiac arrest neonatal 16.02 11.50 5 75075 27 31622237
Epistaxis 15.97 11.50 196 74884 53511 31568753
Infection 15.94 11.50 121 74959 81810 31540454
Hepatitis C 15.80 11.50 3 75077 10627 31611637
Basal cell carcinoma 15.73 11.50 12 75068 18167 31604097
Heart rate abnormal 15.73 11.50 20 75060 1718 31620546
Therapeutic response decreased 15.72 11.50 24 75056 26485 31595779
Hypervolaemia 15.71 11.50 85 74995 18166 31604098
Dysphagia 15.49 11.50 77 75003 57599 31564665
Hirsutism 15.47 11.50 8 75072 182 31622082
Hepatitis fulminant 15.42 11.50 30 75050 3716 31618548
Oesophageal achalasia 15.42 11.50 10 75070 352 31621912
Graft versus host disease 15.42 11.50 3 75077 10444 31611820
Cellulitis 15.38 11.50 60 75020 47958 31574306
Mitral valve incompetence 15.38 11.50 70 75010 13963 31608301
Ischaemic hepatitis 15.36 11.50 19 75061 1588 31620676
Fasting 15.20 11.50 4 75076 10 31622254
Systemic-pulmonary artery shunt 15.14 11.50 3 75077 0 31622264
Bone marrow granuloma 15.14 11.50 3 75077 0 31622264
Angioedema 15.06 11.50 36 75044 33582 31588682
Thyroxine free decreased 15.02 11.50 9 75071 275 31621989
Psoriatic arthropathy 14.94 11.50 15 75065 19868 31602396
Pseudarthrosis 14.92 11.50 6 75074 74 31622190
Diffuse vasculitis 14.71 11.50 6 75074 77 31622187
Hypophonesis 14.68 11.50 4 75076 12 31622252
Axonal neuropathy 14.67 11.50 15 75065 1016 31621248
Abdominal distension 14.65 11.50 184 74896 50500 31571764
Emotional distress 14.55 11.50 70 75010 14286 31607978
Deposit eye 14.46 11.50 5 75075 39 31622225
Non-compaction cardiomyopathy 14.46 11.50 5 75075 39 31622225
Amaurosis 14.39 11.50 12 75068 625 31621639
Bradyarrhythmia 14.29 11.50 21 75059 2070 31620194
Cell death 14.25 11.50 21 75059 2075 31620189
Lymphadenopathy 14.23 11.50 25 75055 26096 31596168
Conduction disorder 14.22 11.50 20 75060 1894 31620370
Bone marrow failure 14.20 11.50 28 75052 27980 31594284
Supraventricular extrasystoles 14.20 11.50 26 75054 3078 31619186
Myopathy 14.11 11.50 57 75023 10795 31611469
Injection site reaction 14.06 11.50 5 75075 11646 31610618
Arthropathy 14.05 11.50 22 75058 24029 31598235
Hepatitis cholestatic 14.02 11.50 43 75037 7103 31615161
Osteoporosis 13.93 11.50 5 75075 11578 31610686
Erectile dysfunction 13.90 11.50 15 75065 19220 31603044
Tri-iodothyronine decreased 13.83 11.50 5 75075 45 31622219
Pericarditis fungal 13.79 11.50 7 75073 153 31622111
Myxoedema 13.79 11.50 4 75076 16 31622248
Paranoia 13.67 11.50 4 75076 10551 31611713
Cardiac dysfunction 13.64 11.50 20 75060 1967 31620297
Chronotropic incompetence 13.60 11.50 4 75076 17 31622247
Osteonecrosis 13.58 11.50 8 75072 13876 31608388
Thyrotoxic periodic paralysis 13.52 11.50 6 75074 96 31622168
Hepatic cirrhosis 13.49 11.50 73 75007 15601 31606663
Mediastinal haemorrhage 13.46 11.50 5 75075 49 31622215
Lung infiltration 13.44 11.50 61 75019 12152 31610112
Leukopenia 13.44 11.50 81 74999 57747 31564517
Arteriosclerotic retinopathy 13.42 11.50 4 75076 18 31622246
Neoplasm progression 13.37 11.50 17 75063 20255 31602009
Localised infection 13.31 11.50 10 75070 15255 31607009
Fascial rupture 13.24 11.50 4 75076 19 31622245
Cardiothoracic ratio increased 13.24 11.50 4 75076 19 31622245
Abdominal pain upper 13.18 11.50 93 74987 63909 31558355
Alveolitis necrotising 13.07 11.50 4 75076 20 31622244
Subdural haematoma evacuation 13.07 11.50 4 75076 20 31622244
Toxic nodular goitre 13.07 11.50 4 75076 20 31622244
Myoglobin urine present 13.05 11.50 7 75073 172 31622092
Traumatic haemothorax 13.05 11.50 8 75072 255 31622009
Bone pain 13.00 11.50 16 75064 19335 31602929
Acute lung injury 12.99 11.50 16 75064 1331 31620933
Vomiting 12.96 11.50 418 74662 223555 31398709
Adrenal haematoma 12.95 11.50 5 75075 55 31622209
Flushing 12.92 11.50 33 75047 30095 31592169
Progressive multifocal leukoencephalopathy 12.87 11.50 3 75077 9210 31613054
Generalised tonic-clonic seizure 12.85 11.50 17 75063 19914 31602350
Nephroangiosclerosis 12.84 11.50 7 75073 178 31622086
Pulseless electrical activity 12.76 11.50 40 75040 6687 31615577
Ventricular dysfunction 12.65 11.50 27 75053 3573 31618691
Linear IgA disease 12.63 11.50 17 75063 1545 31620719
Ulcer haemorrhage 12.62 11.50 22 75058 2505 31619759
Viral infection 12.62 11.50 11 75069 15582 31606682
Drug intolerance 12.56 11.50 72 75008 51961 31570303
Tri-iodothyronine free decreased 12.56 11.50 5 75075 60 31622204
Depressed level of consciousness 12.51 11.50 48 75032 38553 31583711
Hyponatraemic syndrome 12.49 11.50 7 75073 188 31622076
Type 2 diabetes mellitus 12.49 11.50 10 75070 14774 31607490
Pulmonary vascular resistance abnormality 12.48 11.50 5 75075 61 31622203
Prothrombin time shortened 12.46 11.50 16 75064 1388 31620876
Palmar-plantar erythrodysaesthesia syndrome 12.43 11.50 11 75069 15472 31606792
Oedema genital 12.39 11.50 9 75071 382 31621882
Therapeutic drug monitoring analysis not performed 12.35 11.50 10 75070 500 31621764
Blood creatine increased 12.28 11.50 31 75049 4577 31617687
Hypersensitivity pneumonitis 12.25 11.50 16 75064 1412 31620852
Tri-iodothyronine increased 12.20 11.50 5 75075 65 31622199
Proteinuria 12.20 11.50 13 75067 16750 31605514
Dry gangrene 12.07 11.50 9 75071 398 31621866
Electrocardiogram low voltage 12.06 11.50 4 75076 27 31622237
Sinus arrhythmia 12.06 11.50 12 75068 787 31621477
Cardiac disorder 12.04 11.50 144 74936 39070 31583194
Iron deficiency anaemia 12.04 11.50 49 75031 9310 31612954
Psychomotor hyperactivity 12.01 11.50 3 75077 8784 31613480
Atrial conduction time prolongation 11.86 11.50 3 75077 6 31622258
Electrocardiogram QRS complex prolonged 11.85 11.50 29 75051 4200 31618064
Failure to suspend medication 11.82 11.50 9 75071 411 31621853
Arthritis 11.74 11.50 30 75050 27355 31594909
Septic shock 11.71 11.50 221 74859 65937 31556327
Neuromyopathy 11.71 11.50 13 75067 968 31621296
Wolff-Parkinson-White syndrome 11.71 11.50 7 75073 213 31622051
Optic nerve infarction 11.70 11.50 4 75076 30 31622234
Vascular pseudoaneurysm 11.62 11.50 19 75061 2054 31620210
Epilepsy 11.58 11.50 20 75060 21021 31601243
Mesenteric artery thrombosis 11.56 11.50 9 75071 425 31621839
Arterial haemorrhage 11.51 11.50 12 75068 832 31621432

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperthyroidism 2314.54 11.20 958 114422 19133 70793931
Drug interaction 1534.55 11.20 2439 112941 379002 70434062
Atrial fibrillation 1389.62 11.20 1602 113778 182746 70630318
Bradycardia 1196.79 11.20 1231 114149 123384 70689680
Ventricular tachycardia 1072.27 11.20 693 114687 35730 70777334
Torsade de pointes 1017.56 11.20 525 114855 17591 70795473
Pulmonary toxicity 1001.97 11.20 442 114938 10356 70802708
Electrocardiogram QT prolonged 936.31 11.20 898 114482 82619 70730445
Interstitial lung disease 813.13 11.20 925 114455 103760 70709304
Cardiac failure 734.92 11.20 1030 114350 142511 70670553
Acute kidney injury 554.44 11.20 1862 113518 472762 70340302
Thyroiditis 503.74 11.20 204 115176 3832 70809232
Hypothyroidism 499.19 11.20 485 114895 45270 70767794
Cardiogenic shock 473.39 11.20 425 114955 35882 70777182
International normalised ratio increased 473.10 11.20 619 114761 80107 70732957
Ventricular fibrillation 472.24 11.20 375 115005 26736 70786328
Myxoedema coma 388.16 11.20 109 115271 599 70812465
Rheumatoid arthritis 331.65 11.20 42 115338 291763 70521301
Sinus bradycardia 300.94 11.20 273 115107 23350 70789714
Arthralgia 294.51 11.20 233 115147 503157 70309907
Hypotension 287.03 11.20 1359 114021 403022 70410042
Pulmonary fibrosis 284.50 11.20 314 115066 33996 70779068
Headache 265.75 11.20 333 115047 580072 70232992
Syncope 264.75 11.20 727 114653 164982 70648082
Multiple organ dysfunction syndrome 262.52 11.20 559 114821 107956 70705108
Cardiac failure congestive 255.01 11.20 632 114748 134825 70678239
Cardiac arrest 246.21 11.20 692 114688 159142 70653922
Hyperkalaemia 242.88 11.20 536 114844 106055 70707009
Pain 242.47 11.20 407 114973 628409 70184655
Atrial flutter 237.77 11.20 224 115156 20103 70792961
Renal failure 235.98 11.20 760 114620 188310 70624754
Ventricular arrhythmia 222.92 11.20 146 115234 7684 70805380
Thyrotoxic crisis 217.74 11.20 80 115300 1140 70811924
Joint swelling 207.95 11.20 76 115304 253135 70559929
Alopecia 191.53 11.20 44 115336 198446 70614618
Hyponatraemia 191.14 11.20 634 114746 159453 70653611
Gastrointestinal haemorrhage 185.76 11.20 568 114812 136840 70676224
Haematoma 181.52 11.20 301 115079 48117 70764947
Nasopharyngitis 180.23 11.20 68 115312 222138 70590926
Tachyarrhythmia 179.25 11.20 118 115262 6264 70806800
Arrhythmia 179.11 11.20 325 115055 55818 70757246
Appendicolith 176.72 11.20 112 115268 5568 70807496
Pulmonary alveolar haemorrhage 175.33 11.20 141 115239 10228 70802836
Shock haemorrhagic 173.57 11.20 179 115201 17927 70795137
Synovitis 166.94 11.20 11 115369 129217 70683847
Sinus node dysfunction 162.19 11.20 116 115264 7053 70806011
Rash 161.48 11.20 371 115009 510191 70302873
Drug intolerance 161.07 11.20 83 115297 225604 70587460
Infusion related reaction 160.94 11.20 60 115320 197474 70615590
Sinusitis 158.32 11.20 40 115340 169155 70643909
Therapeutic product effect decreased 156.62 11.20 23 115357 142995 70670069
Atrioventricular block 156.44 11.20 144 115236 12544 70800520
Acute respiratory distress syndrome 154.01 11.20 256 115124 40998 70772066
Arthropathy 153.52 11.20 29 115351 150028 70663036
Labelled drug-drug interaction medication error 145.86 11.20 188 115192 23939 70789125
Lung disorder 143.30 11.20 336 115044 69148 70743916
Pain in extremity 142.86 11.20 195 115185 327887 70485177
Blood thyroid stimulating hormone increased 140.61 11.20 114 115266 8365 70804699
Pyrexia 140.10 11.20 512 114868 606440 70206624
Fatigue 138.59 11.20 782 114598 823537 69989527
Hypersensitivity 137.09 11.20 104 115276 229708 70583356
Swelling 136.51 11.20 68 115312 188471 70624593
Completed suicide 131.43 11.20 106 115274 227029 70586035
Rhabdomyolysis 128.56 11.20 395 114985 95365 70717699
Musculoskeletal stiffness 127.02 11.20 41 115339 147719 70665345
Ventricular extrasystoles 126.15 11.20 152 115228 18074 70794990
Haematuria 123.09 11.20 300 115080 63273 70749791
Cerebral haematoma 121.93 11.20 99 115281 7279 70805785
Organising pneumonia 121.85 11.20 113 115267 9937 70803127
Melaena 121.13 11.20 277 115103 56078 70756986
Hand deformity 119.08 11.20 5 115375 86477 70726587
Atrial tachycardia 117.35 11.20 74 115306 3646 70809418
Systemic lupus erythematosus 117.26 11.20 14 115366 101888 70711176
Pemphigus 113.67 11.20 5 115375 83031 70730033
Cardiac failure chronic 112.19 11.20 109 115271 10160 70802904
Hyperglobulinaemia 111.08 11.20 21 115359 3 70813061
Cerebral haemorrhage 108.37 11.20 258 115122 53606 70759458
Glossodynia 107.02 11.20 9 115371 86478 70726586
Long QT syndrome 106.50 11.20 80 115300 5247 70807817
Stomatitis 106.39 11.20 38 115342 128473 70684591
Rectal haemorrhage 106.14 11.20 290 115090 65541 70747523
Pericardial haemorrhage 105.71 11.20 73 115307 4195 70808869
Infusion site phlebitis 105.23 11.20 28 115352 121 70812943
Maternal exposure during pregnancy 104.59 11.20 29 115351 115316 70697748
Atrioventricular block complete 102.57 11.20 125 115255 15038 70798026
Injection site pain 102.22 11.20 32 115348 117587 70695477
Diarrhoea 101.90 11.20 802 114578 782539 70030525
Orthopnoea 101.17 11.20 99 115281 9309 70803755
Abdominal discomfort 94.97 11.20 126 115254 214532 70598532
Dyspnoea 93.30 11.20 1763 113617 768297 70044767
Cardioactive drug level increased 93.14 11.20 63 115317 3499 70809565
Appendicitis 92.81 11.20 125 115255 16608 70796456
Corneal deposits 92.01 11.20 33 115347 437 70812627
Febrile neutropenia 91.34 11.20 119 115261 204199 70608865
Product dose omission issue 90.86 11.20 133 115247 217335 70595729
Nausea 90.80 11.20 918 114462 851170 69961894
Cornea verticillata 90.33 11.20 24 115356 103 70812961
Cardiac failure acute 90.01 11.20 126 115254 17361 70795703
Hypoaesthesia 89.83 11.20 71 115309 153668 70659396
Asthma 89.79 11.20 42 115338 120751 70692313
Respiratory failure 88.93 11.20 523 114857 168212 70644852
Therapeutic product effect incomplete 88.63 11.20 42 115338 119840 70693224
Migraine 88.07 11.20 8 115372 72230 70740834
Back pain 87.18 11.20 195 115185 270957 70542107
Anaemia 87.11 11.20 1021 114359 402402 70410662
Renal injury 85.89 11.20 118 115262 15976 70797088
Ejection fraction decreased 85.57 11.20 168 115212 30594 70782470
Hepatocellular injury 83.41 11.20 212 115168 45879 70767185
Cardio-respiratory arrest 82.80 11.20 354 115026 100323 70712741
Subdural haematoma 81.49 11.20 160 115220 29138 70783926
Wound 80.35 11.20 30 115350 98702 70714362
Urticaria 80.28 11.20 88 115292 162961 70650103
Cholestasis 79.27 11.20 213 115167 47659 70765405
Anticoagulation drug level increased 78.17 11.20 33 115347 691 70812373
Product use issue 76.18 11.20 109 115271 179828 70633236
Acute respiratory failure 75.41 11.20 225 115155 53440 70759624
Muscle spasms 74.90 11.20 84 115296 153962 70659102
Coronary artery bypass 74.56 11.20 68 115312 5852 70807212
Lower respiratory tract infection 74.24 11.20 45 115335 111868 70701196
Pruritus 74.04 11.20 300 115080 345260 70467804
Pneumonitis 73.98 11.20 226 115154 54371 70758693
Respiratory distress 73.85 11.20 226 115154 54424 70758640
Atrioventricular block first degree 73.77 11.20 93 115287 11580 70801484
Pleural effusion 72.70 11.20 416 114964 132448 70680616
Keratopathy 71.97 11.20 34 115346 936 70812128
Coagulopathy 70.95 11.20 163 115217 33086 70779978
Lactic acidosis 70.90 11.20 250 115130 64774 70748290
Mitral valve incompetence 70.77 11.20 143 115237 26585 70786479
Hypokalaemia 70.64 11.20 409 114971 130779 70682285
Cardioversion 69.60 11.20 42 115338 1912 70811152
Off label use 69.28 11.20 825 114555 742235 70070829
Alveolitis 69.09 11.20 54 115326 3757 70809307
Injection site erythema 68.64 11.20 17 115363 72907 70740157
Blood loss anaemia 68.37 11.20 100 115280 14341 70798723
Renal impairment 68.14 11.20 434 114946 143503 70669561
Infection 67.39 11.20 152 115228 210633 70602431
Arthritis 66.97 11.20 38 115342 97942 70715122
Hypoxia 66.82 11.20 315 115065 93029 70720035
Ischaemic stroke 66.77 11.20 152 115228 30668 70782396
Myalgia 65.97 11.20 107 115273 167785 70645279
Insomnia 65.69 11.20 162 115218 217644 70595420
Fall 65.53 11.20 1050 114330 443046 70370018
Pericardial effusion 65.31 11.20 182 115198 41594 70771470
Fibromyalgia 65.13 11.20 3 115377 47871 70765193
Coronary artery disease 63.98 11.20 236 115144 62500 70750564
Anhedonia 63.81 11.20 96 115284 14117 70798947
Discomfort 63.74 11.20 47 115333 105389 70707675
Intentional product use issue 63.49 11.20 61 115319 120081 70692983
Psoriatic arthropathy 63.14 11.20 14 115366 64757 70748307
Venous pressure jugular increased 62.26 11.20 34 115346 1278 70811786
Peripheral swelling 61.60 11.20 189 115191 236374 70576690
Exposure during pregnancy 61.43 11.20 33 115347 87684 70725380
Gastrooesophageal reflux disease 60.99 11.20 36 115344 90803 70722261
Drug-induced liver injury 60.54 11.20 215 115165 55898 70757166
Tachycardia induced cardiomyopathy 60.26 11.20 18 115362 127 70812937
Cardiac tamponade 60.00 11.20 72 115308 8523 70804541
Bundle branch block left 59.69 11.20 79 115301 10320 70802744
Rales 59.52 11.20 103 115277 17032 70796032
Injection site reaction 59.50 11.20 6 115374 49846 70763218
Depression 59.21 11.20 149 115231 198825 70614239
Neutrophil count decreased 59.15 11.20 31 115349 83525 70729539
Palpitations 58.77 11.20 344 115036 110409 70702655
Psoriasis 58.06 11.20 45 115335 98388 70714676
Nodal arrhythmia 57.90 11.20 37 115343 1866 70811198
Herpes zoster 56.91 11.20 34 115346 85201 70727863
Arterial haemorrhage 56.82 11.20 40 115340 2371 70810693
Spontaneous haematoma 56.74 11.20 32 115348 1282 70811782
Anuria 56.69 11.20 109 115271 19544 70793520
White blood cell count decreased 56.59 11.20 120 115260 170021 70643043
Potentiating drug interaction 56.35 11.20 68 115312 8096 70804968
Nodal rhythm 56.21 11.20 43 115337 2898 70810166
Left ventricular dysfunction 56.03 11.20 103 115277 17854 70795210
Drug abuse 55.85 11.20 96 115284 147160 70665904
N-terminal prohormone brain natriuretic peptide increased 55.23 11.20 48 115332 3876 70809188
Seizure 53.94 11.20 132 115248 177830 70635234
Thyroid disorder 53.85 11.20 84 115296 12748 70800316
Suicidal ideation 53.59 11.20 23 115357 69573 70743491
Neuromyopathy 53.50 11.20 32 115348 1433 70811631
Dyspnoea exertional 53.47 11.20 261 115119 78169 70734895
Subarachnoid haemorrhage 52.41 11.20 105 115275 19399 70793665
Heparin-induced thrombocytopenia 52.40 11.20 69 115311 8968 70804096
Abdominal pain upper 52.32 11.20 152 115228 193450 70619614
Thyroxine increased 52.27 11.20 25 115355 708 70812356
Chills 51.68 11.20 98 115282 144688 70668376
Irritable bowel syndrome 51.61 11.20 10 115370 50840 70762224
Thyroxine free increased 51.37 11.20 29 115351 1164 70811900
Folliculitis 51.13 11.20 5 115375 42565 70770499
Ill-defined disorder 51.06 11.20 13 115367 54728 70758336
Eosinophilia 51.02 11.20 163 115217 40156 70772908
Pericarditis 50.88 11.20 38 115342 84667 70728397
Oropharyngeal pain 50.77 11.20 49 115331 96261 70716803
Activated partial thromboplastin time prolonged 50.65 11.20 84 115296 13421 70799643
Anticoagulation drug level above therapeutic 50.47 11.20 42 115338 3196 70809868
Influenza like illness 49.66 11.20 22 115358 65309 70747755
Left ventricular failure 49.62 11.20 66 115314 8662 70804402
Ascites 49.11 11.20 229 115151 67318 70745746
Presyncope 48.88 11.20 153 115227 37285 70775779
Musculoskeletal pain 48.73 11.20 45 115335 90282 70722782
Oedema peripheral 48.55 11.20 576 114804 227515 70585549
General physical health deterioration 48.47 11.20 592 114788 235439 70577625
Ecchymosis 48.29 11.20 85 115295 14247 70798817
Blood pressure increased 48.08 11.20 152 115228 188365 70624699
Septic shock 47.98 11.20 330 115050 111928 70701136
BRASH syndrome 46.26 11.20 22 115358 615 70812449
Blood pressure fluctuation 46.24 11.20 19 115361 58993 70754071
Iodine overload 46.22 11.20 9 115371 3 70813061
Jugular vein distension 45.47 11.20 28 115352 1322 70811742
Haemarthrosis 45.45 11.20 50 115330 5389 70807675
Toxic skin eruption 45.42 11.20 101 115279 20061 70793003
Drug level increased 44.84 11.20 146 115234 36323 70776741
Goitre 44.05 11.20 48 115332 5118 70807946
Malignant neoplasm progression 43.79 11.20 82 115298 121657 70691407
Sedation 43.77 11.20 11 115369 46720 70766344
Prothrombin time shortened 43.47 11.20 37 115343 2905 70810159
Bradyarrhythmia 43.26 11.20 42 115338 3911 70809153
Haemorrhage 42.96 11.20 258 115122 83557 70729507
Asthenia 42.85 11.20 1010 114370 456656 70356408
Muscle haemorrhage 42.24 11.20 50 115330 5834 70807230
Prothrombin time prolonged 42.12 11.20 86 115294 16104 70796960
Weight increased 42.04 11.20 227 115153 242104 70570960
Exercise tolerance decreased 41.81 11.20 59 115321 8189 70804875
Haemorrhage intracranial 41.78 11.20 111 115269 24666 70788398
Lymphatic fistula 41.51 11.20 22 115358 778 70812286
Femoral hernia incarcerated 41.33 11.20 22 115358 785 70812279
Glomerular filtration rate decreased 41.28 11.20 99 115281 20657 70792407
Fear 41.11 11.20 99 115281 20712 70792352
Drug dependence 40.84 11.20 6 115374 37315 70775749
Device pacing issue 40.76 11.20 12 115368 80 70812984
Cardiac murmur 40.70 11.20 72 115308 12114 70800950
Blood creatinine increased 40.69 11.20 383 114997 142618 70670446
C-reactive protein abnormal 40.42 11.20 7 115373 38572 70774492
Haemorrhagic stroke 40.16 11.20 65 115315 10177 70802887
Upper respiratory tract infection 39.87 11.20 42 115338 79232 70733832
Craniocerebral injury 39.75 11.20 43 115337 4548 70808516
Blood phosphorus increased 39.73 11.20 52 115328 6718 70806346
Rhinorrhoea 39.57 11.20 30 115350 66341 70746723
Low cardiac output syndrome 39.50 11.20 22 115358 860 70812204
Gravitational oedema 38.83 11.20 28 115352 1724 70811340
Myocardial infarction 38.53 11.20 438 114942 171207 70641857
Optic neuropathy 38.51 11.20 36 115344 3197 70809867
Haematoma muscle 38.21 11.20 31 115349 2276 70810788
Acute pulmonary oedema 38.21 11.20 74 115306 13338 70799726
Colitis ulcerative 38.19 11.20 5 115375 33918 70779146
Toxicity to various agents 38.11 11.20 851 114529 381321 70431743
Brugada syndrome 37.09 11.20 23 115357 1100 70811964
Cerebellar syndrome 36.81 11.20 44 115336 5187 70807877
Electrocardiogram PR prolongation 36.63 11.20 25 115355 1409 70811655
Blood cholesterol increased 36.27 11.20 31 115349 64573 70748491
Neutropenia 36.23 11.20 257 115123 256899 70556165
Haemothorax 36.21 11.20 43 115337 5034 70808030
Myopathy 36.18 11.20 88 115292 18524 70794540
Head injury 36.12 11.20 130 115250 34011 70779053
Optic ischaemic neuropathy 36.03 11.20 32 115348 2660 70810404
Pancreatic steatosis 35.74 11.20 22 115358 1038 70812026
Shock 35.44 11.20 145 115235 40280 70772784
Contraindicated product administered 35.40 11.20 107 115273 134505 70678559
Cardiac ablation 35.06 11.20 28 115352 2010 70811054
Blister 35.03 11.20 69 115311 100457 70712607
Atrial thrombosis 34.79 11.20 34 115346 3191 70809873
Drug hypersensitivity 34.73 11.20 267 115113 262192 70550872
Pulmonary oedema 34.63 11.20 241 115139 82037 70731027
Sinoatrial block 34.56 11.20 23 115357 1243 70811821
Pacemaker generated rhythm 34.45 11.20 10 115370 63 70813001
Wound infection pseudomonas 34.39 11.20 25 115355 1559 70811505
Osteoarthritis 34.34 11.20 42 115338 74105 70738959
Bone pain 34.31 11.20 20 115360 50802 70762262
Knee arthroplasty 34.28 11.20 7 115373 34294 70778770
Pulmonary hypertension 33.99 11.20 158 115222 46378 70766686
Ischaemic hepatitis 33.88 11.20 34 115346 3295 70809769
Lung infiltration 33.59 11.20 94 115286 21530 70791534
Phlebitis 33.49 11.20 53 115327 8141 70804923
Dyspnoea at rest 33.42 11.20 48 115332 6771 70806293
Extravasation 33.30 11.20 34 115346 3363 70809701
Type 2 diabetes mellitus 33.25 11.20 15 115365 44065 70768999
Hepatitis fulminant 33.24 11.20 47 115333 6534 70806530
Mitochondrial aspartate aminotransferase increased 33.12 11.20 7 115373 7 70813057
Hypervolaemia 32.92 11.20 140 115240 39566 70773498
Haemoptysis 32.78 11.20 168 115212 51284 70761780
Haemodynamic instability 32.57 11.20 76 115304 15582 70797482
Cytomegalovirus infection 32.47 11.20 12 115368 39746 70773318
Cardiac disorder 32.45 11.20 186 115194 59229 70753835
Cardiac output decreased 32.29 11.20 25 115355 1715 70811349
Tricuspid valve incompetence 32.28 11.20 82 115298 17735 70795329
Injection site swelling 32.07 11.20 15 115365 43142 70769922
Myxoedema 32.04 11.20 11 115369 127 70812937
Ischaemic cardiomyopathy 31.91 11.20 48 115332 7056 70806008
Hip arthroplasty 31.89 11.20 4 115376 28036 70785028
International normalised ratio abnormal 31.88 11.20 41 115339 5206 70807858
Hypertension 31.71 11.20 318 115062 295715 70517349
COVID-19 31.59 11.20 79 115301 105678 70707386
Angiodysplasia 31.52 11.20 19 115361 863 70812201
Mobility decreased 31.50 11.20 76 115304 102923 70710141
Adverse event 31.27 11.20 21 115359 49440 70763624
Hepatic failure 31.21 11.20 180 115200 57445 70755619
Swelling face 31.17 11.20 34 115346 63130 70749934
Lymphocyte count decreased 31.04 11.20 16 115364 43523 70769541
Red blood cell sedimentation rate increased 31.00 11.20 12 115368 38630 70774434
Respiratory acidosis 30.86 11.20 58 115322 10223 70802841
Osteonecrosis of jaw 30.86 11.20 14 115366 40988 70772076
Acute hepatic failure 30.68 11.20 107 115273 27565 70785499
Mixed liver injury 30.64 11.20 44 115336 6205 70806859
Hepatitis acute 30.40 11.20 69 115311 13893 70799171
Toxic goitre 30.29 11.20 7 115373 14 70813050
Injection site bruising 30.20 11.20 12 115368 38020 70775044
Treatment failure 29.66 11.20 127 115253 144015 70669049
Cardiovascular insufficiency 29.65 11.20 29 115351 2724 70810340
Xyphoid retraction 29.61 11.20 11 115369 162 70812902
Pancreatitis 29.55 11.20 35 115345 62633 70750431
Fungal infection 29.46 11.20 12 115368 37455 70775609
Anaemia macrocytic 29.33 11.20 39 115341 5116 70807948
Osteoporosis 29.29 11.20 22 115358 48885 70764179
Disease progression 29.28 11.20 143 115237 156529 70656535
Ventricular tachyarrhythmia 29.08 11.20 13 115367 314 70812750
Feeling hot 29.01 11.20 22 115358 48648 70764416
Oral herpes 28.63 11.20 3 115377 24183 70788881
Neck pain 28.56 11.20 40 115340 66617 70746447
Palmar-plantar erythrodysaesthesia syndrome 28.56 11.20 7 115373 30240 70782824
Orthostatic hypotension 28.27 11.20 162 115218 51581 70761483
Throat irritation 28.26 11.20 11 115369 35293 70777771
Suicide attempt 28.20 11.20 54 115326 79456 70733608
Loss of personal independence in daily activities 28.12 11.20 60 115320 84850 70728214
Deep vein thrombosis 27.97 11.20 90 115290 110952 70702112
Femoral artery aneurysm 27.95 11.20 11 115369 191 70812873
Intraocular haematoma 27.81 11.20 7 115373 23 70813041
Platelet distribution width increased 27.77 11.20 10 115370 134 70812930
Glomerular filtration rate 27.77 11.20 10 115370 134 70812930
Cholestatic liver injury 27.60 11.20 34 115346 4134 70808930
Bursitis 27.59 11.20 5 115375 26668 70786396
Hot flush 27.58 11.20 24 115356 49560 70763504
Abdominal wall haematoma 27.52 11.20 35 115345 4395 70808669
Mediastinal haematoma 27.48 11.20 11 115369 200 70812864
Cataract 27.40 11.20 30 115350 55615 70757449
Stress 27.39 11.20 197 115183 67769 70745295
Periorbital haemorrhage 27.38 11.20 11 115369 202 70812862
Cellulitis 27.20 11.20 77 115303 98851 70714213
Feeling abnormal 27.12 11.20 129 115251 142190 70670874
Night sweats 27.01 11.20 19 115361 43665 70769399
Mouth ulceration 27.01 11.20 11 115369 34338 70778726
Vomiting 26.89 11.20 747 114633 592364 70220700
Gastrointestinal angiodysplasia 26.88 11.20 18 115362 983 70812081
Ilium fracture 26.85 11.20 11 115369 213 70812851
Cerebellar haematoma 26.82 11.20 15 115365 591 70812473
Papilloedema 26.81 11.20 40 115340 5838 70807226
Myelosuppression 26.54 11.20 8 115372 30137 70782927
Right ventricular failure 26.33 11.20 88 115292 22186 70790878
Neoplasm progression 26.26 11.20 21 115359 45207 70767857
Antiacetylcholine receptor antibody positive 26.25 11.20 8 115372 61 70813003
Traumatic lung injury 26.18 11.20 25 115355 2280 70810784
Basal cell carcinoma 26.16 11.20 11 115369 33687 70779377
Acute coronary syndrome 26.15 11.20 82 115298 19997 70793067
Extrasystoles 26.10 11.20 43 115337 6831 70806233
Influenza 26.04 11.20 96 115284 113604 70699460
Impaired healing 25.95 11.20 51 115329 74323 70738741
Myoclonus 25.91 11.20 98 115282 26257 70786807
Lower gastrointestinal haemorrhage 25.89 11.20 67 115313 14653 70798411
Seroma 25.88 11.20 24 115356 2110 70810954
Puncture site haematoma 25.88 11.20 10 115370 165 70812899
Epistaxis 25.84 11.20 268 115112 102359 70710705
Flushing 25.63 11.20 60 115320 82112 70730952
Cardioactive drug level above therapeutic 25.56 11.20 11 115369 242 70812822
Memory impairment 25.55 11.20 72 115308 92569 70720495
Gastrointestinal disorder 25.49 11.20 87 115293 105340 70707724
Wheezing 25.37 11.20 74 115306 94096 70718968
Illness 25.29 11.20 10 115370 31781 70781283
Therapeutic response decreased 25.12 11.20 35 115345 58418 70754646
Hypertransaminasaemia 25.06 11.20 49 115331 8894 70804170
Nephrolithiasis 25.02 11.20 24 115356 47299 70765765
Hypoglycaemia 24.99 11.20 249 115131 94115 70718949
Arteriosclerotic gangrene 24.98 11.20 8 115372 73 70812991
Ear pain 24.89 11.20 7 115373 27592 70785472
Drug withdrawal syndrome 24.88 11.20 11 115369 32704 70780360
Anaphylactic reaction 24.81 11.20 53 115327 74921 70738143
Hepatitis cholestatic 24.79 11.20 60 115320 12590 70800474
Thyroiditis acute 24.78 11.20 10 115370 186 70812878
Eosinophilic pneumonia 24.73 11.20 35 115345 4870 70808194
Blood thyroid stimulating hormone decreased 24.71 11.20 37 115343 5417 70807647
Intra-abdominal haematoma 24.69 11.20 26 115354 2666 70810398
Urinary tract infection 24.69 11.20 272 115108 248497 70564567
Intentional overdose 24.64 11.20 80 115300 98355 70714709
Depressed mood 24.63 11.20 21 115359 43799 70769265
Erythema 24.55 11.20 207 115173 199356 70613708
Drug ineffective 24.29 11.20 1266 114114 938486 69874578
Medication error 24.12 11.20 167 115213 56745 70756319
Ear infection 24.09 11.20 8 115372 28328 70784736
Pulmonary embolism 23.82 11.20 152 115228 155715 70657349
Nasal congestion 23.82 11.20 44 115336 65628 70747436
Urine iodine increased 23.66 11.20 5 115375 5 70813059
Iodine uptake abnormal 23.66 11.20 5 115375 5 70813059
Haemorrhagic diathesis 23.64 11.20 37 115343 5630 70807434
Left atrial enlargement 23.54 11.20 17 115363 1049 70812015
Cystitis 23.46 11.20 25 115355 46916 70766148
Blood creatine increased 23.33 11.20 47 115333 8717 70804347
Platelet count decreased 23.23 11.20 182 115198 178040 70635024
Tri-iodothyronine increased 23.15 11.20 10 115370 222 70812842
Retroperitoneal haemorrhage 23.12 11.20 35 115345 5174 70807890
Acute generalised exanthematous pustulosis 23.00 11.20 66 115314 15331 70797733
Pemphigoid 22.81 11.20 62 115318 13960 70799104
Aortic valve incompetence 22.81 11.20 47 115333 8857 70804207
Device inappropriate shock delivery 22.78 11.20 7 115373 55 70813009
Alveolar proteinosis 22.66 11.20 14 115366 665 70812399
Vascular purpura 22.52 11.20 25 115355 2721 70810343
Secondary hyperthyroidism 22.35 11.20 6 115374 27 70813037
Cardiac pacemaker insertion 22.31 11.20 35 115345 5337 70807727
Accidental exposure to product 22.03 11.20 9 115371 28042 70785022
Diabetes mellitus 21.96 11.20 53 115327 71771 70741293
Jaundice 21.81 11.20 148 115232 49960 70763104
Halo vision 21.66 11.20 13 115367 586 70812478
Conduction disorder 21.57 11.20 26 115354 3092 70809972
Hepatic enzyme increased 21.56 11.20 158 115222 156832 70656232
Neonatal pneumonia 21.51 11.20 6 115374 32 70813032
Neonatal hypotension 21.51 11.20 6 115374 32 70813032
Acne 21.34 11.20 7 115373 24982 70788082
Supine hypertension 21.31 11.20 11 115369 368 70812696
Cell death 21.22 11.20 30 115350 4170 70808894
Supraventricular extrasystoles 21.19 11.20 37 115343 6161 70806903
Localised infection 21.06 11.20 14 115366 33144 70779920
Cyanosis 20.95 11.20 84 115296 23122 70789942
Electrocardiogram QRS complex prolonged 20.84 11.20 48 115332 9758 70803306
Mucosal inflammation 20.80 11.20 50 115330 67800 70745264
Device capturing issue 20.78 11.20 6 115374 37 70813027
Bundle branch block 20.77 11.20 18 115362 1448 70811616
Cardiomegaly 20.70 11.20 87 115293 24458 70788606
Product quality issue 20.66 11.20 12 115368 30549 70782515
Irritability 20.66 11.20 19 115361 38206 70774858
Pharyngitis 20.66 11.20 4 115376 20347 70792717
Myocardial ischaemia 20.58 11.20 86 115294 24114 70788950
Feeling cold 20.41 11.20 8 115372 25562 70787502
Skin disorder 20.41 11.20 12 115368 30345 70782719
Hepatotoxicity 20.40 11.20 132 115248 43854 70769210
Subcutaneous haematoma 20.33 11.20 23 115357 2556 70810508
Lupus pneumonitis 20.29 11.20 7 115373 82 70812982
Aerophagia 20.25 11.20 6 115374 41 70813023
Body temperature increased 20.15 11.20 21 115359 39813 70773251
Coma uraemic 20.13 11.20 6 115374 42 70813022
Musculoskeletal disorder 20.11 11.20 4 115376 19967 70793097
Oliguria 20.10 11.20 62 115318 14989 70798075
Conjunctival haemorrhage 19.96 11.20 33 115347 5257 70807807
Hypophonesis 19.73 11.20 5 115375 17 70813047
Paraesthesia 19.73 11.20 147 115233 145390 70667674
Inappropriate schedule of product administration 19.61 11.20 99 115281 107456 70705608
Joint stiffness 19.60 11.20 17 115363 35159 70777905
Central nervous system injury 19.52 11.20 8 115372 155 70812909
Orchitis 19.24 11.20 16 115364 1216 70811848
Hypoxic-ischaemic encephalopathy 19.22 11.20 39 115341 7269 70805795
Pseudolymphoma 19.21 11.20 15 115365 1042 70812022
Sciatica 19.18 11.20 8 115372 24619 70788445
Supraventricular tachycardia 19.13 11.20 73 115307 19637 70793427
Thyroid function test abnormal 19.13 11.20 24 115356 2973 70810091
Amaurosis 19.05 11.20 15 115365 1055 70812009
Diaphragmatic paralysis 18.96 11.20 15 115365 1062 70812002
Osteonecrosis 18.95 11.20 12 115368 29148 70783916
Amnesia 18.86 11.20 35 115345 52120 70760944
Atrioventricular block second degree 18.82 11.20 37 115343 6741 70806323
Sudden death 18.82 11.20 76 115304 20988 70792076
Aortic valve stenosis 18.80 11.20 31 115349 4928 70808136
Bone disorder 18.71 11.20 3 115377 17487 70795577
Viral infection 18.57 11.20 21 115359 38370 70774694
Acute interstitial pneumonitis 18.56 11.20 15 115365 1095 70811969
Arrhythmia supraventricular 18.51 11.20 19 115361 1891 70811173
Normocytic anaemia 18.45 11.20 26 115354 3604 70809460
Bundle branch block right 18.36 11.20 48 115332 10562 70802502
Conjunctivitis 18.21 11.20 7 115373 22629 70790435
Pulseless electrical activity 18.17 11.20 55 115325 13160 70799904
Respiratory disorder neonatal 18.16 11.20 6 115374 61 70813003
Blood pressure decreased 18.09 11.20 228 115152 91287 70721777
Intentional self-injury 17.99 11.20 15 115365 31635 70781429
Withdrawal syndrome 17.98 11.20 9 115371 24895 70788169
Crepitations 17.80 11.20 42 115338 8672 70804392
Thyroxine free decreased 17.74 11.20 14 115366 988 70812076
Heart transplant 17.72 11.20 16 115364 1359 70811705
Traumatic haemothorax 17.70 11.20 10 115370 402 70812662
Unevaluable event 17.68 11.20 145 115235 51918 70761146
Agranulocytosis 17.52 11.20 119 115261 40179 70772885
Oral pain 17.50 11.20 13 115367 29053 70784011
Listless 17.34 11.20 25 115355 3538 70809526
Local anaesthetic systemic toxicity 17.31 11.20 13 115367 852 70812212
Vascular pseudoaneurysm 17.31 11.20 24 115356 3277 70809787
Injection site haemorrhage 17.29 11.20 10 115370 25517 70787547
Plasma cell myeloma 17.29 11.20 61 115319 73140 70739924
Hyperglycaemia 17.29 11.20 51 115329 64621 70748443
Orthostatic hypertension 17.19 11.20 12 115368 702 70812362
Thrombotic microangiopathy 17.11 11.20 4 115376 17844 70795220
Wrong technique in product usage process 17.07 11.20 56 115324 68642 70744422
Atrioventricular dissociation 17.01 11.20 9 115371 317 70812747
Blood glucose increased 17 11.20 98 115282 102884 70710180
Neuralgia 16.96 11.20 13 115367 28590 70784474
Pain in jaw 16.93 11.20 27 115353 42642 70770422
Device issue 16.87 11.20 9 115371 24016 70789048
Tooth disorder 16.76 11.20 9 115371 23929 70789135
Gastroenteritis viral 16.66 11.20 7 115373 21448 70791616
Cardiorenal syndrome 16.49 11.20 16 115364 1488 70811576
Electrocardiogram RR interval prolonged 16.42 11.20 4 115376 11 70813053
Dysgeusia 16.37 11.20 35 115345 49467 70763597
Crying 16.33 11.20 7 115373 21192 70791872
Paranoia 16.32 11.20 4 115376 17284 70795780
Non-compaction cardiomyopathy 16.30 11.20 5 115375 39 70813025
Endovenous ablation 16.27 11.20 3 115377 0 70813064
Concomitant disease aggravated 16.27 11.20 50 115330 12064 70801000
Ocular hyperaemia 16.20 11.20 10 115370 24629 70788435
Hepatic cyst 16.19 11.20 31 115349 5540 70807524
Ulcer 16.19 11.20 11 115369 25743 70787321
Burning sensation 16.17 11.20 39 115341 52831 70760233
Anti-thyroid antibody positive 16.17 11.20 10 115370 476 70812588
Blood pressure systolic increased 16.16 11.20 44 115336 57215 70755849
Eye pain 16.12 11.20 19 115361 34083 70778981
Chronic kidney disease 16.11 11.20 161 115219 60896 70752168
Systemic inflammatory response syndrome 16.08 11.20 46 115334 10666 70802398
Scrotal oedema 16.04 11.20 15 115365 1333 70811731
Splenic injury 16.00 11.20 8 115372 250 70812814
Accessory cardiac pathway 15.93 11.20 4 115376 13 70813051
Full blood count abnormal 15.88 11.20 19 115361 33859 70779205
Neuropathy peripheral 15.88 11.20 131 115249 126765 70686299
Colitis 15.87 11.20 52 115328 63762 70749302
Sneezing 15.85 11.20 4 115376 16947 70796117
Transplant rejection 15.68 11.20 5 115375 18166 70794898
Anticoagulation drug level below therapeutic 15.67 11.20 15 115365 1372 70811692
Pericarditis fungal 15.63 11.20 7 115373 170 70812894
Foot deformity 15.62 11.20 7 115373 20648 70792416
Chorea 15.49 11.20 18 115362 2060 70811004
Procedural pain 15.46 11.20 5 115375 18004 70795060
Coagulation test abnormal 15.44 11.20 14 115366 1196 70811868
Toxic nodular goitre 15.39 11.20 5 115375 48 70813016
Bone erosion 15.36 11.20 3 115377 15170 70797894
Thyrotoxic periodic paralysis 15.36 11.20 6 115374 102 70812962
Subdural haemorrhage 15.32 11.20 30 115350 5451 70807613
Throat tightness 15.32 11.20 11 115369 25011 70788053
Obstructive airways disorder 15.31 11.20 12 115368 26101 70786963
Mental disorder 15.31 11.20 14 115366 28226 70784838
Paroxysmal arrhythmia 15.30 11.20 5 115375 49 70813015
Haemorrhagic thyroid cyst 15.28 11.20 4 115376 16 70813048
Reduced facial expression 15.28 11.20 19 115361 2333 70810731
Sopor 15.22 11.20 95 115285 31172 70781892
Rash pruritic 15.21 11.20 52 115328 62939 70750125
Intervertebral disc protrusion 15.18 11.20 8 115372 21495 70791569
Lung opacity 15.15 11.20 24 115356 3689 70809375
Electrocardiogram T wave abnormal 15.10 11.20 23 115357 3419 70809645
Dry skin 15.03 11.20 44 115336 55887 70757177
Anxiety 14.99 11.20 260 115120 220070 70592994
Diffuse vasculitis 14.95 11.20 6 115374 110 70812954
Neutrophil count increased 14.86 11.20 13 115367 26782 70786282
Ventricular remodelling 14.85 11.20 6 115374 112 70812952
Faecaloma 14.85 11.20 44 115336 10407 70802657
Congestive hepatopathy 14.82 11.20 25 115355 4049 70809015
Retroperitoneal haematoma 14.81 11.20 28 115352 4957 70808107
Hypovolaemic shock 14.80 11.20 45 115335 10792 70802272
Mesenteric artery thrombosis 14.73 11.20 10 115370 559 70812505
Fascial rupture 14.73 11.20 4 115376 19 70813045
Intraventricular haemorrhage 14.69 11.20 26 115354 4375 70808689
Limb discomfort 14.64 11.20 16 115364 29689 70783375
Thyroglobulin increased 14.62 11.20 5 115375 57 70813007
Serotonin syndrome 14.58 11.20 29 115351 42085 70770979
Inflammation 14.57 11.20 72 115308 78593 70734471
Alveolitis necrotising 14.56 11.20 4 115376 20 70813044
Treatment noncompliance 14.53 11.20 34 115346 46540 70766524
Diabetic ketoacidosis 14.43 11.20 18 115362 31494 70781570
Renal function test abnormal 14.38 11.20 25 115355 4149 70808915
Photosensitivity reaction 14.37 11.20 66 115314 19274 70793790
Hypothermia 14.36 11.20 69 115311 20525 70792539
Bone marrow failure 14.33 11.20 37 115343 48973 70764091
Therapeutic drug monitoring analysis not performed 14.32 11.20 15 115365 1529 70811535
Failure to suspend medication 14.28 11.20 9 115371 443 70812621
Thrombin time prolonged 14.22 11.20 8 115372 319 70812745
Dry eye 14.20 11.20 19 115361 32263 70780801
Brain natriuretic peptide increased 14.17 11.20 37 115343 8134 70804930
Generalised tonic-clonic seizure 14.16 11.20 29 115351 41632 70771432
Liver function test abnormal 14.14 11.20 157 115223 60989 70752075
Hepatojugular reflux 14.07 11.20 10 115370 602 70812462
Dissociation 14.02 11.20 22 115358 3354 70809710
Hypoglycaemic seizure 14.00 11.20 11 115369 771 70812293
Red blood cell sedimentation rate abnormal 13.90 11.20 7 115373 19296 70793768
C-reactive protein increased 13.87 11.20 114 115266 110403 70702661
Oesophageal infection 13.82 11.20 10 115370 619 70812445
Gastroenteritis aeromonas 13.81 11.20 4 115376 25 70813039
Oedema genital 13.78 11.20 9 115371 471 70812593
Ventricular dysfunction 13.68 11.20 29 115351 5575 70807489
Eye swelling 13.66 11.20 11 115369 23603 70789461
Device dislocation 13.64 11.20 10 115370 22497 70790567
Splenic haemorrhage 13.54 11.20 10 115370 639 70812425
Diverticulum intestinal 13.53 11.20 36 115344 8005 70805059
Sleep disorder 13.50 11.20 63 115317 69809 70743255
Sinus disorder 13.46 11.20 7 115373 18952 70794112
Adrenal haematoma 13.46 11.20 6 115374 144 70812920
Injection site warmth 13.45 11.20 3 115377 13822 70799242
Drug reaction with eosinophilia and systemic symptoms 13.43 11.20 149 115231 57864 70755200
Foreign body 13.40 11.20 19 115361 2649 70810415
Tooth infection 13.39 11.20 5 115375 16458 70796606
Lymphadenopathy 13.39 11.20 38 115342 48753 70764311
Live birth 13.38 11.20 3 115377 13776 70799288
Leukopenia 13.33 11.20 110 115270 106450 70706614
Vascular stent thrombosis 13.33 11.20 22 115358 3501 70809563
Nodule 13.28 11.20 8 115372 19961 70793103
Swollen tongue 13.27 11.20 25 115355 37021 70776043
Electrocardiogram QRS complex shortened 13.22 11.20 10 115370 663 70812401
Hypochromasia 13.20 11.20 10 115370 664 70812400
Graft versus host disease 13.20 11.20 4 115376 15019 70798045
Rash maculo-papular 13.20 11.20 133 115247 50412 70762652
Arteriosclerotic retinopathy 13.18 11.20 4 115376 30 70813034
Infective pericardial effusion 13.18 11.20 4 115376 30 70813034
Vascular graft 13.10 11.20 16 115364 1928 70811136
Axonal neuropathy 13.10 11.20 16 115364 1928 70811136
Altered visual depth perception 13.08 11.20 8 115372 373 70812691
Chest X-ray abnormal 13.06 11.20 33 115347 7111 70805953
Ventricular enlargement 13.03 11.20 9 115371 517 70812547
Drug clearance decreased 13.03 11.20 20 115360 2993 70810071
Hypernatraemia 13.00 11.20 48 115332 12713 70800351
Bronchitis 12.93 11.20 125 115255 117118 70695946
Hypocoagulable state 12.91 11.20 16 115364 1957 70811107
Blood triglycerides increased 12.90 11.20 8 115372 19656 70793408
Sinus arrhythmia 12.88 11.20 16 115364 1962 70811102
Colonic haematoma 12.86 11.20 5 115375 84 70812980
Electrocardiogram low voltage 12.85 11.20 4 115376 33 70813031
Neuroleptic malignant syndrome 12.83 11.20 14 115366 25993 70787071
Foot fracture 12.83 11.20 8 115372 19592 70793472
Amyloidosis 12.80 11.20 19 115361 2760 70810304
Toothache 12.80 11.20 7 115373 18423 70794641
Lymphoid tissue hyperplasia 12.80 11.20 7 115373 264 70812800
Weight decreased 12.78 11.20 396 114984 310092 70502972
Pulmonary haemorrhage 12.75 11.20 50 115330 13623 70799441
Aphthous ulcer 12.70 11.20 4 115376 14652 70798412
Kidney infection 12.65 11.20 8 115372 19447 70793617
Fasting 12.64 11.20 4 115376 35 70813029
Prerenal failure 12.61 11.20 21 115359 3365 70809699
Oesophageal achalasia 12.61 11.20 10 115370 711 70812353
Obesity 12.57 11.20 15 115365 26756 70786308
Carpal tunnel syndrome 12.56 11.20 6 115374 17051 70796013
Product storage error 12.55 11.20 4 115376 14537 70798527
Oesophageal adenocarcinoma recurrent 12.54 11.20 4 115376 36 70813028
Hyperthermia 12.46 11.20 57 115323 16614 70796450
Iron deficiency anaemia 12.44 11.20 72 115308 23000 70790064
Hospitalisation 12.36 11.20 81 115299 82487 70730577
Optic atrophy 12.33 11.20 15 115365 1800 70811264
Hepatitis 12.33 11.20 130 115250 49850 70763214
Toxic epidermal necrolysis 12.28 11.20 108 115272 39449 70773615
Haemoperitoneum 12.26 11.20 23 115357 4048 70809016
Wolff-Parkinson-White syndrome 12.24 11.20 7 115373 288 70812776
Electrocardiogram T wave inversion 12.24 11.20 26 115354 5005 70808059
Dry mouth 12.20 11.20 66 115314 70391 70742673
Secretion discharge 12.20 11.20 3 115377 12930 70800134
Lip swelling 12.18 11.20 23 115357 34031 70779033
Demyelinating polyneuropathy 12.18 11.20 14 115366 1583 70811481
Tachypnoea 12.11 11.20 84 115296 28554 70784510
Ventricular flutter 12.10 11.20 5 115375 99 70812965
Ventricular hypokinesia 12.07 11.20 35 115345 8177 70804887
Linear IgA disease 12.07 11.20 19 115361 2905 70810159
Sinus arrest 12.06 11.20 20 115360 3195 70809869
Paraesthesia oral 12.02 11.20 5 115375 15412 70797652
Pelvic fracture 12.01 11.20 43 115337 11218 70801846
Panic attack 11.95 11.20 11 115369 22108 70790956
Cardiac dysfunction 11.94 11.20 21 115359 3516 70809548
Microcytic anaemia 11.94 11.20 25 115355 4764 70808300
Transaminases increased 11.93 11.20 123 115257 46895 70766169
Postrenal failure 11.92 11.20 9 115371 595 70812469
Cyst 11.90 11.20 3 115377 12716 70800348
Lung consolidation 11.83 11.20 35 115345 8271 70804793
Blood cyanide increased 11.82 11.20 4 115376 44 70813020
Flatulence 11.81 11.20 28 115352 38153 70774911
Petechiae 11.79 11.20 62 115318 19110 70793954
Extradural haematoma 11.76 11.20 18 115362 2687 70810377
Wound dehiscence 11.69 11.20 29 115351 6179 70806885
Eosinophilia myalgia syndrome 11.67 11.20 3 115377 11 70813053
Purpura 11.66 11.20 59 115321 17916 70795148
Impaired work ability 11.65 11.20 6 115374 16334 70796730
Nephroangiosclerosis 11.63 11.20 7 115373 317 70812747
Dilatation ventricular 11.58 11.20 22 115358 3909 70809155
Optic disc haemorrhage 11.49 11.20 5 115375 113 70812951
Liver scan abnormal 11.44 11.20 4 115376 49 70813015
Laryngitis 11.33 11.20 4 115376 13627 70799437
Subdural haematoma evacuation 11.29 11.20 4 115376 51 70813013
Arterial insufficiency 11.25 11.20 7 115373 337 70812727
Therapy non-responder 11.24 11.20 76 115304 76839 70736225
Dialysis 11.21 11.20 57 115323 17345 70795719

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac arrest neonatal 41.28 40.06 11 86 83 89612

Pharmacologic Action:

SourceCodeDescription
ATC C01BD01 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
ANTIARRHYTHMICS, CLASS I AND III
Antiarrhythmics, class III
FDA EPC N0000175426 Antiarrhythmic
CHEBI has role CHEBI:35554 cardiovascular agent
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D065609 Cytochrome P-450 CYP1A2 Inhibitors
MeSH PA D065688 Cytochrome P-450 CYP2C9 Inhibitors
MeSH PA D065690 Cytochrome P-450 CYP2D6 Inhibitors
MeSH PA D065692 Cytochrome P-450 CYP3A Inhibitors
MeSH PA D065607 Cytochrome P-450 Enzyme Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D065606 Metabolic Side Effects of Drugs and Substances
MeSH PA D026902 Potassium Channel Blockers
MeSH PA D026941 Sodium Channel Blockers
MeSH PA D014665 Vasodilator Agents
FDA MoA N0000182137 Cytochrome P450 2D6 Inhibitors
FDA MoA N0000182138 Cytochrome P450 1A2 Inhibitors
FDA MoA N0000182141 Cytochrome P450 3A4 Inhibitors
FDA MoA N0000185503 P-Glycoprotein Inhibitors
FDA MoA N0000185504 Cytochrome P450 2C9 Inhibitors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Ventricular fibrillation indication 71908006
Prevention of Ventricular Fibrillation indication
Life-Threatening Ventricular Tachycardia indication
Atrial fibrillation off-label use 49436004 DOID:0060224
Cardioversion of Atrial Fibrillation off-label use
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation off-label use
Complete atrioventricular block contraindication 27885002
Torsades de pointes contraindication 31722008
Hyperthyroidism contraindication 34486009 DOID:7998
Extrinsic allergic alveolitis contraindication 37471005 DOID:841
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Refractive keratoplasty by laser surgery contraindication 58076004
Sinus node dysfunction contraindication 60423000
Interstitial pneumonia contraindication 64667001
Optic neuritis contraindication 66760008 DOID:1210
Corneal deposit contraindication 74460005 DOID:11547
Disorder of optic nerve contraindication 77157004 DOID:1891
Pulmonary hemorrhage contraindication 78144005
Cardiogenic shock contraindication 89138009
Thyrotoxicosis contraindication 90739004 DOID:7997
Prolonged QT interval contraindication 111975006
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Second degree atrioventricular block contraindication 195042002
Disease of liver contraindication 235856003 DOID:409
Drug-induced hepatitis contraindication 235876009
Pregnancy, function contraindication 289908002
Peripheral nerve disease contraindication 302226006
Eosinophilic asthma contraindication 367542003 DOID:9498
Surgical procedure contraindication 387713003
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Congenital long QT syndrome contraindication 442917000
Syncope due to Bradycardia contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.72 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Potassium voltage-gated channel subfamily H member 2 Ion channel BLOCKER IC50 5 WOMBAT-PK CHEMBL
Cytochrome P450 3A4 Enzyme Ki 6.22 WOMBAT-PK
Beta-1 adrenergic receptor GPCR IC50 4.70 WOMBAT-PK
Sodium channel protein type 5 subunit alpha Ion channel BLOCKER IC50 7.10 WOMBAT-PK
Mu-type opioid receptor GPCR Ki 5.11 DRUG MATRIX
D(1A) dopamine receptor GPCR Ki 5.34 DRUG MATRIX
D(2) dopamine receptor GPCR Ki 5.18 DRUG MATRIX
Alpha-2A adrenergic receptor GPCR IC50 6.30 WOMBAT-PK
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 7 WOMBAT-PK
Thyroid hormone receptor alpha Nuclear hormone receptor IC50 5.64 WOMBAT-PK
Thyroid hormone receptor beta Nuclear hormone receptor IC50 6.22 WOMBAT-PK
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase Enzyme Ki 7.60 WOMBAT-PK
Multidrug resistance protein 1 Transporter Ki 5.30 WOMBAT-PK
Sodium-dependent serotonin transporter Transporter Ki 5.91 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.65 DRUG MATRIX
5-hydroxytryptamine receptor 2A GPCR Ki 5.99 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 6.23 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 6.67 DRUG MATRIX
5-hydroxytryptamine receptor 6 GPCR Ki 5.05 DRUG MATRIX
Alpha-2B adrenergic receptor GPCR Ki 5.23 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 6.39 DRUG MATRIX
Histamine H2 receptor GPCR Ki 4.98 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 6.20 DRUG MATRIX
Muscarinic acetylcholine receptor M2 GPCR Ki 5.74 DRUG MATRIX
Muscarinic acetylcholine receptor M3 GPCR Ki 6.17 DRUG MATRIX
Muscarinic acetylcholine receptor M4 GPCR Ki 6.30 DRUG MATRIX
Muscarinic acetylcholine receptor M5 GPCR Ki 5.97 DRUG MATRIX
Beta-3 adrenergic receptor GPCR Ki 4.50 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.70 DRUG MATRIX
Adenosine receptor A3 GPCR Ki 5.00 DRUG MATRIX
D(4) dopamine receptor GPCR Ki 5.21 DRUG MATRIX
Kappa-type opioid receptor GPCR Ki 5.18 DRUG MATRIX
Delta-type opioid receptor GPCR Ki 5.55 DRUG MATRIX
Cytochrome P450 2C9 Enzyme EC50 7.40 WOMBAT-PK
Voltage-dependent T-type calcium channel subunit alpha-1H Ion channel Ki 5.28 WOMBAT-PK
Endothelin-1 receptor GPCR Ki 4.79 DRUG MATRIX
Squalene monooxygenase Enzyme IC50 4.92 CHEMBL
Tyrosine-protein kinase Fyn Kinase IC50 6.09 DRUG MATRIX
Receptor tyrosine-protein kinase erbB-2 Kinase IC50 5.04 DRUG MATRIX
Squalene synthase Enzyme IC50 5.10 CHEMBL
C-C chemokine receptor type 2 GPCR Ki 5.37 DRUG MATRIX
Substance-K receptor GPCR Ki 5.19 DRUG MATRIX
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Ion channel IC50 5.35 WOMBAT-PK
Potassium voltage-gated channel subfamily A member 7 Ion channel IC50 6 WOMBAT-PK
B2 bradykinin receptor GPCR Ki 5.12 DRUG MATRIX
Melanocortin receptor 4 GPCR Ki 4.88 DRUG MATRIX
Melanocortin receptor 5 GPCR Ki 5.05 DRUG MATRIX
Melanocortin receptor 3 GPCR Ki 4.97 DRUG MATRIX
C-C chemokine receptor type 4 GPCR Ki 4.94 DRUG MATRIX
THAP domain-containing protein 1 Unclassified IC50 6.19 WOMBAT-PK
NAD-dependent deacetylase sirtuin 3 Enzyme EC50 5.49 CHEMBL
Lysine-specific demethylase PHF2 Enzyme IC50 4.08 CHEMBL
Lysine-specific demethylase 5A Enzyme IC50 4 CHEMBL
Lysine-specific demethylase 7A Enzyme IC50 4.10 CHEMBL
Androgen receptor Transcription factor Ki 4.55 DRUG MATRIX
Lethal factor Enzyme IC50 5.46 CHEMBL
5-hydroxytryptamine receptor 1B GPCR Ki 4.41 DRUG MATRIX
Membrane-associated progesterone receptor component 1 Membrane receptor IC50 6.93 DRUG MATRIX
C-8 sterol isomerase Enzyme Ki 7.21 CHEMBL
Cruzipain Enzyme IC50 5.40 CHEMBL
Sodium channel protein type 5 subunit alpha Ion channel BLOCKER IC50 5.70 IUPHAR

External reference:

IDSource
4019606 VUID
N0000147701 NUI
D00636 KEGG_DRUG
19774-82-4 SECONDARY_CAS_RN
203114 RXNORM
C0002598 UMLSCUI
CHEBI:2663 CHEBI
BBI PDB_CHEM_ID
CHEMBL633 ChEMBL_ID
CHEMBL1083993 ChEMBL_ID
D000638 MESH_DESCRIPTOR_UI
DB01118 DRUGBANK_ID
2566 IUPHAR_LIGAND_ID
2012 INN_ID
N3RQ532IUT UNII
2157 PUBCHEM_CID
000629 NDDF
004484 NDDF
372821002 SNOMEDCT_US
52574003 SNOMEDCT_US
69236009 SNOMEDCT_US
4018065 VANDF
4019606 VANDF
13960 MMSL
4177 MMSL
d00002 MMSL

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9875 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 26 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9875 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 26 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0185-0144 TABLET 200 mg ORAL ANDA 27 sections
Pacerone HUMAN PRESCRIPTION DRUG LABEL 1 0245-0144 TABLET 100 mg ORAL ANDA 30 sections
Pacerone HUMAN PRESCRIPTION DRUG LABEL 1 0245-0145 TABLET 400 mg ORAL ANDA 27 sections
Pacerone HUMAN PRESCRIPTION DRUG LABEL 1 0245-0145 TABLET 400 mg ORAL ANDA 27 sections
Pacerone HUMAN PRESCRIPTION DRUG LABEL 1 0245-0147 TABLET 200 mg ORAL ANDA 30 sections
Pacerone HUMAN PRESCRIPTION DRUG LABEL 1 0245-1645 TABLET 400 mg ORAL ANDA 30 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0404-9815 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 16 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0404-9815 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 16 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0404-9815 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 16 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0615-8258 TABLET 200 mg ORAL ANDA 27 sections
Amiodarone hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6556 TABLET 200 mg ORAL ANDA 19 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6993 TABLET 200 mg ORAL ANDA 28 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 16714-843 TABLET 100 mg ORAL ANDA 28 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 16714-844 TABLET 200 mg ORAL ANDA 28 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 16714-845 TABLET 400 mg ORAL ANDA 28 sections
Amiodarone hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-796 TABLET 200 mg ORAL ANDA 25 sections
amiodarone hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 25021-302 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 28 sections
amiodarone hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 25021-302 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 28 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 29300-359 TABLET 200 mg ORAL ANDA 19 sections
Amiodarone HCl HUMAN PRESCRIPTION DRUG LABEL 1 42494-307 TABLET 100 mg ORAL ANDA 29 sections
Amiodarone HCl HUMAN PRESCRIPTION DRUG LABEL 1 42494-308 TABLET 200 mg ORAL ANDA 29 sections
Amiodarone HCl HUMAN PRESCRIPTION DRUG LABEL 1 42494-309 TABLET 400 mg ORAL ANDA 29 sections
Nexterone HUMAN PRESCRIPTION DRUG LABEL 1 43066-150 INJECTION, SOLUTION 1.50 mg INTRAVENOUS NDA 25 sections
Nexterone HUMAN PRESCRIPTION DRUG LABEL 1 43066-360 INJECTION, SOLUTION 1.80 mg INTRAVENOUS NDA 25 sections
Amiodarone Hydrochloride Human Prescription Drug Label 1 50090-3015 TABLET 200 mg ORAL ANDA 30 sections
Amiodarone Hydrochloride Human Prescription Drug Label 1 50090-3015 TABLET 200 mg ORAL ANDA 30 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-3496 TABLET 200 mg ORAL ANDA 27 sections
Amiodarone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-5062 TABLET 200 mg ORAL ANDA 27 sections