methscopolamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1757 | 13265-10-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 12 | mg | O |
| 12 | mg | P |
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| April 9, 1953 | FDA | FOUGERA PHARMS |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A03BB03 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS BELLADONNA AND DERIVATIVES, PLAIN Belladonna alkaloids, semisynthetic, quaternary ammonium compounds |
| ATC | A03CB01 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS ANTISPASMODICS IN COMBINATION WITH PSYCHOLEPTICS Belladonna and derivatives in combination with psycholeptics |
| ATC | S01FA03 | SENSORY ORGANS OPHTHALMOLOGICALS MYDRIATICS AND CYCLOPLEGICS Anticholinergics |
| FDA MoA | N0000175370 | Cholinergic Antagonists |
| FDA EPC | N0000175574 | Anticholinergic |
| CHEBI has role | CHEBI:48876 | muscarinic antagonists |
| CHEBI has role | CHEBI:50370 | parasympatholytics |
| CHEBI has role | CHEBI:50919 | antiemetico |
| CHEBI has role | CHEBI:53784 | antispasmodics |
| MeSH PA | D010276 | Parasympatholytics |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Vasomotor rhinitis | indication | 8229003 | DOID:4730 |
| Irritable bowel syndrome | indication | 10743008 | DOID:9778 |
| Cough | indication | 49727002 | |
| Allergic rhinitis | indication | 61582004 | |
| Nasal discharge | indication | 64531003 | |
| Nasal congestion | indication | 68235000 | |
| Common cold | indication | 82272006 | DOID:10459 |
| Rhinitis | off-label use | 70076002 | DOID:4483 |
| Seasonal allergic rhinitis | off-label use | 367498001 | |
| Brain damage | contraindication | 2470005 | |
| Ocular hypertension | contraindication | 4210003 | DOID:9282 |
| Tachyarrhythmia | contraindication | 6285003 | |
| Suicidal thoughts | contraindication | 6471006 | |
| Urinary tract obstruction | contraindication | 7163005 | DOID:5200 |
| Peptic ulcer | contraindication | 13200003 | DOID:750 |
| Chronic obstructive lung disease | contraindication | 13645005 | DOID:3083 |
| Severe chronic ulcerative colitis | contraindication | 14311001 | |
| Disorder of lung | contraindication | 19829001 | DOID:850 |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Glaucoma | contraindication | 23986001 | DOID:1686 |
| Ventricular tachycardia | contraindication | 25569003 | |
| Alcohol intoxication | contraindication | 25702006 | |
| Shock | contraindication | 27942005 | |
| Toxic megacolon | contraindication | 28536002 | DOID:1770 |
| Atony of colon | contraindication | 29479008 | |
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Depressive disorder | contraindication | 35489007 | |
| Acute hepatitis | contraindication | 37871000 | |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Complete trisomy 21 syndrome | contraindication | 41040004 | DOID:14250 |
| Hyperactive behavior | contraindication | 44548000 | |
| Achalasia of esophagus | contraindication | 45564002 | DOID:9164 |
| Chronic heart failure | contraindication | 48447003 | |
| Bradycardia | contraindication | 48867003 | |
| Acidosis | contraindication | 51387008 | |
| Coronary arteriosclerosis | contraindication | 53741008 | DOID:3393 |
| Paralytic ileus | contraindication | 55525008 | DOID:8442 |
| Peptic reflux disease | contraindication | 57643001 | |
| Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
| Arterial thrombosis | contraindication | 65198009 | |
| Drug AND/OR toxin-induced diarrhea | contraindication | 65979008 | |
| Substance abuse | contraindication | 66214007 | |
| Psychotic disorder | contraindication | 69322001 | |
| Arteriosclerotic vascular disease | contraindication | 72092001 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Sleep apnea | contraindication | 73430006 | DOID:0050847 |
| Spastic paralysis | contraindication | 78403003 | |
| Disturbance of salivary secretion | contraindication | 78948009 | |
| Chronic idiopathic constipation | contraindication | 82934008 | |
| Hiatal hernia | contraindication | 84089009 | DOID:12642 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Myasthenia gravis | contraindication | 91637004 | DOID:437 |
| Hypoalbuminemia | contraindication | 119247004 | |
| Gastrointestinal obstruction | contraindication | 126765001 | |
| Autonomic dysreflexia | contraindication | 129618003 | |
| Bleeding | contraindication | 131148009 | |
| Partial atrioventricular block | contraindication | 195039008 | |
| Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
| Myocardial dysfunction | contraindication | 233928007 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Bladder outflow obstruction | contraindication | 236645006 | |
| Pyloric obstruction | contraindication | 244815007 | |
| Benign prostatic hyperplasia | contraindication | 266569009 | |
| Retention of urine | contraindication | 267064002 | |
| Drowsy | contraindication | 271782001 | |
| Pregnancy, function | contraindication | 289908002 | |
| Severe chronic obstructive pulmonary disease | contraindication | 313299006 | |
| Hypoxia | contraindication | 389086002 | |
| Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
| Gastric ulcer | contraindication | 397825006 | DOID:10808 |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Chronic lung disease | contraindication | 413839001 | |
| Disorder of coronary artery | contraindication | 414024009 | |
| Porphyria | contraindication | 418470004 | |
| Hypertensive urgency | contraindication | 443482000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.24 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M1 | GPCR | ANTAGONIST | Ki | 9.90 | IUPHAR | CHEMBL | |||
| Muscarinic acetylcholine receptor M3 | GPCR | ANTAGONIST | Ki | 10.40 | IUPHAR | IUPHAR | |||
| Muscarinic acetylcholine receptor M2 | GPCR | Ki | 9.82 | CHEMBL | |||||
| Muscarinic acetylcholine receptor M4 | GPCR | Ki | 10.01 | CHEMBL | |||||
| Muscarinic acetylcholine receptor M5 | GPCR | Ki | 9.68 | CHEMBL | |||||
| Muscarinic acetylcholine receptor M3 | GPCR | EC50 | 10.30 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019830 | VUID |
| N0000147918 | NUI |
| 155-41-9 | SECONDARY_CAS_RN |
| 6106-46-3 | SECONDARY_CAS_RN |
| 4018075 | VANDF |
| 4018747 | VANDF |
| 4019830 | VANDF |
| C0301374 | UMLSCUI |
| CHEBI:135361 | CHEBI |
| 3C0 | PDB_CHEM_ID |
| CHEMBL1201268 | ChEMBL_ID |
| CHEMBL376897 | ChEMBL_ID |
| DB11315 | DRUGBANK_ID |
| CHEMBL1201024 | ChEMBL_ID |
| CHEMBL1354199 | ChEMBL_ID |
| 71183 | PUBCHEM_CID |
| 316 | IUPHAR_LIGAND_ID |
| VDR09VTQ8U | UNII |
| DB00462 | DRUGBANK_ID |
| 56092 | RXNORM |
| 5082 | MMSL |
| 5083 | MMSL |
| 92758 | MMSL |
| d00989 | MMSL |
| 001720 | NDDF |
| 001721 | NDDF |
| 001722 | NDDF |
| 28415002 | SNOMEDCT_US |
| 372690005 | SNOMEDCT_US |
| 49371000 | SNOMEDCT_US |
| 713368001 | SNOMEDCT_US |
| 717775003 | SNOMEDCT_US |
| D019832 | MESH_DESCRIPTOR_UI |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Methscopolamine Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0482 | TABLET | 2.50 mg | ORAL | NDA authorized generic | 24 sections |
| Methscopolamine Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0483 | TABLET | 5 mg | ORAL | NDA authorized generic | 24 sections |
| Pamine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10337-061 | TABLET | 2.50 mg | ORAL | NDA | 25 sections |
| Pamine Forte | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10337-062 | TABLET | 5 mg | ORAL | NDA | 25 sections |
| METHSCOPOLAMINE BROMIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-740 | TABLET | 2.50 mg | ORAL | ANDA | 22 sections |
| METHSCOPOLAMINE BROMIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-740 | TABLET | 2.50 mg | ORAL | ANDA | 22 sections |
| METHSCOPOLAMINE BROMIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-741 | TABLET | 5 mg | ORAL | ANDA | 22 sections |
| METHSCOPOLAMINE BROMIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43063-741 | TABLET | 5 mg | ORAL | ANDA | 22 sections |
| Methscopolamine Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51991-191 | TABLET | 2.50 mg | ORAL | ANDA | 24 sections |
| Methscopolamine Bromide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51991-192 | TABLET | 5 mg | ORAL | ANDA | 24 sections |
| METHSCOPOLAMINE BROMIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 76385-100 | TABLET | 2.50 mg | ORAL | ANDA | 22 sections |
| METHSCOPOLAMINE BROMIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 76385-101 | TABLET | 5 mg | ORAL | ANDA | 22 sections |