methoxamine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1753 390-28-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methoxamine
  • methoxamin
  • methoxamine hydrochloride
  • methoxamine HCl
An alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION.
  • Molecular weight: 211.26
  • Formula: C11H17NO3
  • CLOGP: 0.59
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 64.71
  • ALOGS: -1.36
  • ROTB: 4

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
30 mg P

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.58 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
None FDA GLAXOSMITHKLINE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01CA10 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
Adrenergic and dopaminergic agents
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D058646 Adrenergic alpha-1 Receptor Agonists
MeSH PA D000316 Adrenergic alpha-Agonists
CHEBI has role CHEBI:137431 antihypotensive agent
CHEBI has role CHEBI:35569 alpha-adrenergic agonist
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D013566 Sympathomimetics
MeSH PA D014662 Vasoconstrictor Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Low blood pressure indication 45007003
Paroxysmal supraventricular tachycardia indication 67198005

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.7 acidic
pKa2 8.68 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Alpha-1D adrenergic receptor GPCR AGONIST EC50 4.90 WOMBAT-PK CHEMBL
Alpha-1B adrenergic receptor GPCR AGONIST Ki 4 IUPHAR CHEMBL
Alpha-1A adrenergic receptor GPCR AGONIST EC50 5.10 WOMBAT-PK CHEMBL
Adrenergic receptor alpha-2 GPCR IC50 5.44 CHEMBL
Alpha-1D adrenergic receptor GPCR AGONIST Ki 4.50 IUPHAR

External reference:

IDSource
4019829 VUID
N0000147917 NUI
C0025681 UMLSCUI
D01020 KEGG_DRUG
54406003 SNOMEDCT_US
4019829 VANDF
6853 RXNORM
372769005 SNOMEDCT_US
d00703 MMSL
004723 NDDF
8MB4MJ9R7L UNII
61-16-5 SECONDARY_CAS_RN
6082 PUBCHEM_CID
CHEBI:6839 CHEBI
CHEMBL524 ChEMBL_ID
DB00723 DRUGBANK_ID
209 INN_ID
CHEMBL1201103 ChEMBL_ID
D008729 MESH_DESCRIPTOR_UI
483 IUPHAR_LIGAND_ID

Pharmaceutical products:

None