All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

methoxamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
	1753	390-28-3

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: methoxamine methoxamin methoxamine hydrochloride methoxamine HCl	An alpha-1 adrenergic agonist that causes prolonged peripheral VASOCONSTRICTION. Molecular weight: 211.26 Formula: C11H17NO3 CLOGP: 0.59 LIPINSKI: 0 HAC: 4 HDO: 2 TPSA: 64.71 ALOGS: -1.36 ROTB: 4 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
30	mg	P

ADMET properties:

Property	Value	Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)	1.58 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,IGF1R,IKBKB,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MET,MTOR,NTRK2,PDK2,PDK4,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,ZAP70	45
kinase-selectivity-class	AXL,BRAF,EIF2AK3,GRK2,MAP2K6,PDK4	6
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

Date	Agency	Company	Orphan
None	FDA	GLAXOSMITHKLINE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	C01CA10	CARDIOVASCULAR SYSTEM CARDIAC THERAPY CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES Adrenergic and dopaminergic agents
MeSH PA	D000316	Adrenergic alpha-Agonists
MeSH PA	D002317	Cardiovascular Agents
MeSH PA	D013566	Sympathomimetics
MeSH PA	D014662	Vasoconstrictor Agents
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D018663	Adrenergic Agents
MeSH PA	D058646	Adrenergic alpha-1 Receptor Agonists
CHEBI has role	CHEBI:35554	cardiovascular drug
CHEBI has role	CHEBI:35569	α-adrenergic agonist
CHEBI has role	CHEBI:137431	antihypotensive agent

Related Drugs by ATC class:

C01CA Adrenergic and dopaminergic agents 25 drugs

amezinium metilsulfatearbutaminecafedrinedimetofrinedobutaminedopaminedopexaminedroxidopaephedrineepinephrineetilefrinefenoldopam show all 25 →

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Low blood pressure	indication	45007003
Paroxysmal supraventricular tachycardia	indication	67198005

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	12.7	acidic
pKa2	8.68	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Alpha-1A adrenergic receptor	GPCR	P35348	ADA1A_HUMAN	AGONIST	EC50	5.10		WOMBAT-PK	CHEMBL
Alpha-1D adrenergic receptor	GPCR	P25100	ADA1D_HUMAN	AGONIST	EC50	4.90		WOMBAT-PK	CHEMBL
Alpha-1B adrenergic receptor	GPCR	P35368	ADA1B_HUMAN	AGONIST	Ki	4		IUPHAR	CHEMBL
Alpha-1D adrenergic receptor	GPCR		ADA1D_RAT	AGONIST	Ki	4.50		IUPHAR
Adrenergic receptor alpha-2	GPCR		ADA2B_RAT ADA2C_RAT ADA2A_RAT		IC50	5.44		CHEMBL

External reference:

ID	Source
4019829	VUID
N0000147917	NUI
D01020	KEGG_DRUG
4018779	VANDF
4019829	VANDF
C0025681	UMLSCUI
CHEBI:6839	CHEBI
CHEMBL524	ChEMBL_ID
DB00723	DRUGBANK_ID
CHEMBL1201103	ChEMBL_ID
D008729	MESH_DESCRIPTOR_UI
6082	PUBCHEM_CID
483	IUPHAR_LIGAND_ID
209	INN_ID
61-16-5	SECONDARY_CAS_RN
HUQ1KC1YLI	UNII
203187	RXNORM
5079	MMSL
d00703	MMSL
001798	NDDF
004723	NDDF
21303006	SNOMEDCT_US
372769005	SNOMEDCT_US
54406003	SNOMEDCT_US
HUQ1KC1YLI	INXIGHT DRUGS

Pharmaceutical products:

None