methocarbamol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1747 532-03-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methocarbamol
  • glycerylguaiacolate carbamate
  • guaiacol glyceryl ether carbamate
  • guaiphenesin carbamate
  • guaiamar carbamate
A centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1206)
  • Molecular weight: 241.24
  • Formula: C11H15NO5
  • CLOGP: 0.15
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 91.01
  • ALOGS: -1.76
  • ROTB: 7
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
3 g O
3 g P

ADMET properties:

PropertyValueReference
BA (Bioavailability) 32 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
July 16, 1957 FDA AUXILIUM PHARMS LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 215.09 10.89 254 30147 144804 90453242
Pemphigus 89.39 10.89 5 30396 326859 90271187
Synovitis 87.31 10.89 6 30395 329746 90268300
Surgery 78.99 10.89 86 30315 44801 90553245
Contraindicated product administered 78.78 10.89 8 30393 320131 90277915
Distributive shock 75.64 10.89 32 30369 3392 90594654
Maternal exposure during pregnancy 74.68 10.89 15 30386 360048 90237998
Product dose omission issue 71.72 10.89 238 30163 291449 90306597
Blood pressure inadequately controlled 71.48 10.89 37 30364 6187 90591859
Pericarditis 71.26 10.89 5 30396 270146 90327900
Systemic lupus erythematosus 67.33 10.89 19 30382 361877 90236169
Exercise tolerance decreased 64.77 10.89 37 30364 7514 90590532
Diabetes mellitus inadequate control 64.33 10.89 52 30349 18632 90579414
Necrosis ischaemic 62.20 10.89 20 30381 975 90597071
Drug intolerance 61.53 10.89 37 30364 447554 90150492
Hand deformity 60.09 10.89 13 30388 296349 90301697
Multiple drug therapy 59.20 10.89 34 30367 6975 90591071
Treatment failure 58.33 10.89 15 30386 303913 90294133
Glossodynia 56.07 10.89 19 30382 321760 90276286
Infusion related reaction 55.14 10.89 36 30365 416744 90181302
Spinal operation 54.54 10.89 37 30364 10159 90587887
Wound 54.35 10.89 17 30384 302963 90295083
Suspected suicide 54.25 10.89 36 30365 9532 90588514
Jaw clicking 51.71 10.89 11 30390 99 90597947
Pneumonia streptococcal 50.61 10.89 21 30380 2120 90595926
Gallbladder polyp 50.56 10.89 17 30384 954 90597092
Joint swelling 48.00 10.89 59 30342 503241 90094805
Anti-cyclic citrullinated peptide antibody positive 46.66 10.89 11 30390 236422 90361624
Fall 46.26 10.89 298 30103 481512 90116534
Acquired haemophilia 45.13 10.89 16 30385 1053 90596993
Beta haemolytic streptococcal infection 44.13 10.89 20 30381 2499 90595547
Product administration interrupted 43.50 10.89 35 30366 12457 90585589
Rheumatoid factor positive 42.96 10.89 4 30397 171646 90426400
Back pain 42.84 10.89 215 30186 316960 90281086
Liver injury 42.62 10.89 4 30397 170563 90427483
Depression 42.18 10.89 206 30195 300395 90297651
Muscle injury 41.94 10.89 5 30396 176649 90421397
Duodenal ulcer perforation 40.43 10.89 12 30389 221276 90376770
Rheumatic fever 39.88 10.89 3 30398 153118 90444928
Illness 39.62 10.89 86 30315 81883 90516163
Hepatic enzyme increased 39.11 10.89 38 30363 360698 90237348
Intervertebral disc protrusion 37.57 10.89 46 30355 27150 90570896
Helicobacter infection 36.80 10.89 15 30386 226835 90371211
Exposure during pregnancy 36.72 10.89 17 30384 238393 90359653
Impaired quality of life 36.69 10.89 42 30359 23102 90574944
Therapeutic product effect decreased 36.65 10.89 24 30377 277547 90320499
Hepatitis viral 36.32 10.89 12 30389 638 90597408
Lower respiratory tract infection 34.02 10.89 21 30380 250638 90347408
Folliculitis 33.99 10.89 13 30388 204340 90393706
Feeling abnormal 33.77 10.89 128 30273 167107 90430939
Respiratory arrest 33.16 10.89 48 30353 33263 90564783
Amnesia 32.60 10.89 95 30306 108410 90489636
Attention deficit hyperactivity disorder 31.91 10.89 19 30382 4165 90593881
Cardio-respiratory arrest 31.37 10.89 67 30334 63073 90534973
Anxiety 31.16 10.89 194 30207 309578 90288468
Thyroid atrophy 31.08 10.89 9 30392 307 90597739
Depressed mood 30.58 10.89 58 30343 50164 90547882
Injection site pain 30.30 10.89 127 30274 173572 90424474
Stomatitis 29.69 10.89 29 30372 274669 90323377
Sleep disorder due to general medical condition, insomnia type 29.68 10.89 4 30397 128690 90469356
Somnolence 29.10 10.89 143 30258 208941 90389105
Embolia cutis medicamentosa 28.58 10.89 10 30391 633 90597413
Dermatitis atopic 28.14 10.89 37 30364 23435 90574611
C-reactive protein increased 27.82 10.89 13 30388 181376 90416670
Alopecia 27.76 10.89 80 30321 494991 90103055
Swollen joint count increased 26.76 10.89 3 30398 111203 90486843
Pre-existing condition improved 26.36 10.89 23 30378 9146 90588900
Type 2 diabetes mellitus 26.25 10.89 18 30383 203226 90394820
Malabsorption 25.83 10.89 18 30383 5160 90592886
Amyloid arthropathy 25.27 10.89 12 30389 1668 90596378
Synovial cyst 25.13 10.89 25 30376 11727 90586319
Pharyngeal swelling 24.75 10.89 23 30378 9921 90588125
Alkalosis hypochloraemic 24.22 10.89 7 30394 237 90597809
Swelling 24.01 10.89 67 30334 418991 90179055
Bronchitis 23.75 10.89 108 30293 152819 90445227
Therapy interrupted 23.56 10.89 52 30349 50056 90547990
Exposure via skin contact 23.31 10.89 23 30378 10682 90587364
Multiple sclerosis 23.29 10.89 37 30364 27803 90570243
Wheezing 22.56 10.89 28 30373 238052 90359994
Febrile neutropenia 21.85 10.89 13 30388 158336 90439710
Analgesic drug level increased 21.60 10.89 13 30388 2906 90595140
Suicidal ideation 21.54 10.89 64 30337 73791 90524255
Product dose omission in error 21.07 10.89 30 30371 20473 90577573
Cognitive disorder 21.06 10.89 61 30340 69346 90528700
Impaired healing 20.70 10.89 29 30372 234170 90363876
Intervertebral disc disorder 20.51 10.89 16 30385 5444 90592602
Thrombocytopenia 20.36 10.89 24 30377 208701 90389345
Hypersensitivity 20.34 10.89 81 30320 454596 90143450
General physical health deterioration 20.17 10.89 57 30344 355058 90242988
Toxicity to various agents 20.04 10.89 165 30236 287681 90310365
Spinal osteoarthritis 19.66 10.89 28 30373 19120 90578926
Gastrointestinal disorder 19.64 10.89 35 30366 256652 90341394
Hepatic pain 19.12 10.89 13 30388 3582 90594464
Irritable bowel syndrome 19.03 10.89 25 30376 207423 90390623
Wound infection 19.01 10.89 6 30395 106396 90491650
Multiple sclerosis relapse 18.89 10.89 49 30352 52256 90545790
Facet joint syndrome 18.58 10.89 5 30396 98384 90499662
Hyperlipidaemia 18.55 10.89 30 30371 22886 90575160
Blister 18.42 10.89 36 30365 254962 90343084
Kidney infection 18.40 10.89 32 30369 25884 90572162
Off label use 18.39 10.89 260 30141 1101992 89496054
Ill-defined disorder 18.31 10.89 21 30380 184870 90413176
Rib fracture 17.94 10.89 32 30369 26403 90571643
Pulmonary fibrosis 17.60 10.89 7 30394 107496 90490550
Withdrawal syndrome 17.57 10.89 29 30372 22495 90575551
COVID-19 17.12 10.89 106 30295 168737 90429309
Eye irritation 16.81 10.89 36 30365 33942 90564104
Muscle spasms 16.79 10.89 143 30258 251740 90346306
Loss of consciousness 16.78 10.89 92 30309 140146 90457900
Rheumatoid arthritis 16.59 10.89 64 30337 362550 90235496
Breast cancer stage III 16.51 10.89 4 30397 84443 90513603
Nausea 16.26 10.89 487 29914 1109829 89488217
Joint range of motion decreased 16.23 10.89 13 30388 135630 90462416
Neutropenia 16.03 10.89 32 30369 224872 90373174
Oesophagitis 15.93 10.89 24 30377 17225 90580821
Inflammation 15.89 10.89 22 30379 178570 90419476
Insurance issue 15.89 10.89 19 30382 10939 90587107
Obstruction 15.85 10.89 12 30389 3909 90594137
Musculoskeletal stiffness 15.82 10.89 49 30352 296483 90301563
Leukopenia 15.78 10.89 7 30394 100703 90497343
Thyroiditis chronic 15.63 10.89 3 30398 15 90598031
Urinary tract infection 15.16 10.89 163 30238 305469 90292577
Neuralgia 15.16 10.89 33 30368 31467 90566579
Cardiac failure 15.09 10.89 9 30392 109487 90488559
Pulmonary pain 15.05 10.89 13 30388 5101 90592945
Restless legs syndrome 14.99 10.89 27 30374 22443 90575603
Live birth 14.98 10.89 4 30397 79103 90518943
Overdose 14.74 10.89 97 30304 157612 90440434
Vitamin B12 deficiency 14.32 10.89 15 30386 7471 90590575
Spinal fracture 14.12 10.89 26 30375 21990 90576056
Hunger 14.10 10.89 14 30387 6549 90591497
Generalised tonic-clonic seizure 13.96 10.89 34 30367 34869 90563177
Emotional distress 13.91 10.89 35 30366 36627 90561419
Prescribed underdose 13.82 10.89 4 30397 75015 90523031
Metabolic encephalopathy 13.77 10.89 14 30387 6738 90591308
Back disorder 13.66 10.89 28 30373 25603 90572443
Prescribed overdose 13.48 10.89 8 30393 97617 90500429
Migraine 13.17 10.89 109 30292 190283 90407763
Burning sensation 13.16 10.89 49 30352 63403 90534643
Head injury 13.14 10.89 31 30370 31157 90566889
Hypermagnesaemia 13.13 10.89 7 30394 1242 90596804
Therapy cessation 13.06 10.89 34 30367 36327 90561719
Wrong technique in product usage process 12.99 10.89 53 30348 71518 90526528
Temperature intolerance 12.95 10.89 18 30383 12012 90586034
Contusion 12.93 10.89 135 30266 251081 90346965
Haemorrhoids 12.88 10.89 28 30373 26674 90571372
Discomfort 12.82 10.89 48 30353 274287 90323759
Cervical spinal stenosis 12.77 10.89 9 30392 2626 90595420
Essential hypertension 12.71 10.89 13 30388 6302 90591744
Intentional dose omission 12.68 10.89 22 30379 17761 90580285
Upper respiratory tract infection 12.65 10.89 80 30321 128238 90469808
Musculoskeletal pain 12.52 10.89 24 30377 171227 90426819
Treatment noncompliance 12.49 10.89 42 30359 51685 90546361
Pain 12.22 10.89 428 29973 995913 89602133
Malignant neoplasm of spinal cord 12.19 10.89 3 30398 54 90597992
Product distribution issue 12.10 10.89 10 30391 3695 90594351
Seizure 11.99 10.89 90 30311 152539 90445507
Malignant neoplasm progression 11.86 10.89 11 30390 106859 90491187
Nerve compression 11.66 10.89 16 30385 10550 90587496
Hospitalisation 11.49 10.89 78 30323 128022 90470024
Weight decreased 11.45 10.89 185 30216 379725 90218321
Influenza 11.44 10.89 83 30318 139181 90458865
Arthropathy 11.38 10.89 74 30327 366168 90231878
Urinary incontinence 11.38 10.89 33 30368 37533 90560513
Somnambulism 11.07 10.89 12 30389 6216 90591830
Angioedema 10.96 10.89 47 30354 64829 90533217
Hepatitis 10.95 10.89 5 30396 70734 90527312
Interstitial lung disease 10.92 10.89 6 30395 76399 90521647

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Respiratory depression 179.11 15.11 94 12265 18774 42590202
Drug dependence 163.52 15.11 103 12256 28991 42579985
Child abuse 137.07 15.11 35 12324 857 42608119
Product prescribing error 118.76 15.11 81 12278 26031 42582945
Epidural lipomatosis 112.76 15.11 35 12324 1765 42607211
Juvenile idiopathic arthritis 99.62 15.11 35 12324 2604 42606372
Victim of child abuse 78.20 15.11 24 12335 1165 42607811
Obesity 54.17 15.11 42 12317 16417 42592559
Tenderness 51.24 15.11 32 12327 8851 42600125
Spinal operation 42.80 15.11 22 12337 4198 42604778
Narcolepsy 37.80 15.11 12 12347 651 42608325
Drug abuse 37.18 15.11 89 12270 104682 42504294
Back pain 33.80 15.11 104 12255 141672 42467304
Intentional product misuse 29.23 15.11 59 12300 61841 42547135
Product use issue 29.18 15.11 67 12292 76684 42532292
Depression 28.70 15.11 84 12275 111279 42497697
Fall 28.58 15.11 139 12220 234381 42374595
Phonophobia 23.62 15.11 7 12352 301 42608675
Pain 22.27 15.11 134 12225 244714 42364262
Pancytopenia 21.60 15.11 4 12355 117739 42491237
Back disorder 20.11 15.11 17 12342 7497 42601479
Amnesia 19.66 15.11 32 12327 28405 42580571
Blood lactic acid increased 19.12 15.11 17 12342 8022 42600954
Anxiety 18.74 15.11 76 12283 118484 42490492
Serum procollagen type III N-terminal propeptide increased 17.77 15.11 4 12355 56 42608920
May-Thurner syndrome 17.04 15.11 3 12356 10 42608966
Neutropenia 16.65 15.11 20 12339 199411 42409565
Intervertebral disc degeneration 16.38 15.11 15 12344 7352 42601624
General physical health deterioration 16.35 15.11 12 12347 151234 42457742
Back injury 16.30 15.11 12 12347 4336 42604640
Subgaleal haematoma 16.11 15.11 4 12355 87 42608889
Thrombocytopenia 15.97 15.11 19 12340 190260 42418716

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 215.14 11.72 315 33588 242066 110313330
Respiratory depression 149.12 11.72 103 33800 31898 110523498
Drug dependence 136.24 11.72 117 33786 49903 110505493
Child abuse 135.23 11.72 35 33868 854 110554542
Epidural lipomatosis 106.06 11.72 35 33868 2032 110553364
Product prescribing error 86.28 11.72 92 33811 51239 110504157
Spinal operation 80.34 11.72 47 33856 10925 110544471
Victim of child abuse 76.43 11.72 24 33879 1187 110554209
Juvenile idiopathic arthritis 69.92 11.72 35 33868 5972 110549424
Synovitis 67.94 11.72 4 33899 274088 110281308
Blood pressure inadequately controlled 64.76 11.72 36 33867 7597 110547799
Distributive shock 64.63 11.72 33 33870 5871 110549525
Fall 63.12 11.72 357 33546 603125 109952271
Back pain 62.50 11.72 252 33651 370744 110184652
Surgery 62.43 11.72 70 33833 41213 110514183
Product dose omission issue 60.24 11.72 226 33677 321556 110233840
Suspected suicide 59.48 11.72 44 33859 15155 110540241
Necrosis ischaemic 57.85 11.72 20 33883 1339 110554057
Multiple drug therapy 57.81 11.72 34 33869 7980 110547416
Pericarditis 54.91 11.72 3 33900 219111 110336285
Infusion related reaction 53.43 11.72 25 33878 381137 110174259
Jaw clicking 53.31 11.72 11 33892 93 110555303
Exercise tolerance decreased 49.63 11.72 36 33867 12031 110543365
Drug intolerance 49.24 11.72 32 33871 406480 110148916
Depression 48.29 11.72 209 33694 317126 110238270
Respiratory arrest 47.64 11.72 73 33830 58226 110497170
Diabetes mellitus inadequate control 47.63 11.72 52 33851 29723 110525673
Gallbladder polyp 47.37 11.72 17 33886 1270 110554126
Maternal exposure during pregnancy 45.64 11.72 11 33892 254872 110300524
Helicobacter infection 44.03 11.72 3 33900 181874 110373522
Glossodynia 42.99 11.72 8 33895 221996 110333400
Beta haemolytic streptococcal infection 42.70 11.72 20 33883 2951 110552445
Contraindicated product administered 42.00 11.72 12 33891 248255 110307141
Wound 40.28 11.72 11 33892 234426 110320970
Systemic lupus erythematosus 39.99 11.72 14 33889 254324 110301072
Pneumonia streptococcal 39.64 11.72 20 33883 3469 110551927
Treatment failure 39.12 11.72 18 33885 277216 110278180
Intentional product misuse 37.12 11.72 107 33796 132797 110422599
Product administration interrupted 36.11 11.72 29 33874 11263 110544133
Anxiety 35.89 11.72 204 33699 344874 110210522
Hepatic enzyme increased 35.26 11.72 28 33875 320864 110234532
Liver injury 34.94 11.72 3 33900 150410 110404986
Folliculitis 34.78 11.72 5 33898 167648 110387748
Amnesia 34.55 11.72 90 33813 105318 110450078
Thrombocytopenia 34.07 11.72 34 33869 348851 110206545
Feeling abnormal 33.84 11.72 127 33776 180584 110374812
Cardio-respiratory arrest 33.07 11.72 94 33809 115742 110439654
Acquired haemophilia 32.61 11.72 16 33887 2615 110552781
Thyroid atrophy 32.14 11.72 9 33894 298 110555098
Intervertebral disc protrusion 32.06 11.72 41 33862 27657 110527739
Spinal osteoarthritis 31.85 11.72 35 33868 20148 110535248
Drug abuse 31.83 11.72 123 33780 177288 110378108
General physical health deterioration 30.67 11.72 52 33851 425243 110130153
Joint swelling 30.27 11.72 56 33847 442789 110112607
Narcolepsy 30.19 11.72 13 33890 1575 110553821
Depressed mood 29.98 11.72 61 33842 60748 110494648
Dermatitis atopic 29.87 11.72 38 33865 25503 110529893
Neutropenia 29.68 11.72 43 33860 374577 110180819
Impaired quality of life 27.99 11.72 40 33863 29977 110525419
Febrile neutropenia 27.49 11.72 34 33869 316733 110238663
Muscle injury 27.41 11.72 5 33898 140802 110414594
Therapeutic product effect decreased 27.24 11.72 21 33882 244295 110311101
Tenderness 27.12 11.72 39 33864 29398 110525998
Attention deficit hyperactivity disorder 27.11 11.72 17 33886 4474 110550922
Cognitive disorder 26.93 11.72 73 33830 87438 110467958
Amyloid arthropathy 26.30 11.72 12 33891 1668 110553728
Intervertebral disc degeneration 26.21 11.72 30 33873 18055 110537341
Back disorder 25.86 11.72 32 33871 20890 110534506
Illness 25.75 11.72 69 33834 82102 110473294
Stomatitis 25.62 11.72 27 33876 270215 110285181
Embolia cutis medicamentosa 25.52 11.72 10 33893 953 110554443
Pain 25.32 11.72 422 33481 954533 109600863
Hepatitis viral 24.56 11.72 11 33892 1464 110553932
Drug abuser 24.23 11.72 17 33886 5392 110550004
Pharyngeal swelling 22.79 11.72 23 33880 12009 110543387
Sleep disorder due to general medical condition, insomnia type 22.26 11.72 3 33900 105640 110449756
Synovial cyst 21.93 11.72 22 33881 11408 110543988
Drug-induced liver injury 21.84 11.72 5 33898 120062 110435334
Impaired healing 21.81 11.72 17 33886 196700 110358696
Temperature intolerance 21.68 11.72 24 33879 13926 110541470
Hyperlipidaemia 21.40 11.72 39 33864 35809 110519587
Blister 21.24 11.72 23 33880 227353 110328043
Lower respiratory tract infection 21.18 11.72 26 33877 243080 110312316
Cardiac failure 21.07 11.72 16 33887 187610 110367786
Contusion 21.07 11.72 133 33770 233228 110322168
Alopecia 20.84 11.72 51 33852 364702 110190694
Exposure during pregnancy 20.50 11.72 13 33890 167411 110387985
Emotional distress 19.79 11.72 43 33860 44804 110510592
Multiple sclerosis relapse 19.75 11.72 46 33857 50194 110505202
Insurance issue 19.58 11.72 20 33883 10592 110544804
Intervertebral disc disorder 19.44 11.72 15 33888 5497 110549899
Exposure via skin contact 19.37 11.72 22 33881 13125 110542271
Hepatic pain 19.30 11.72 14 33889 4676 110550720
Rib fracture 19.23 11.72 36 33867 33734 110521662
Analgesic drug level increased 19.08 11.72 13 33890 3933 110551463
Head injury 18.71 11.72 41 33862 42976 110512420
Pancytopenia 18.71 11.72 22 33881 209591 110345805
Alkalosis hypochloraemic 18.65 11.72 7 33896 594 110554802
Somnolence 18.48 11.72 155 33748 297294 110258102
Injection site pain 18.35 11.72 105 33798 177817 110377579
Eye irritation 18.23 11.72 35 33868 33417 110521979
Interstitial lung disease 18.21 11.72 10 33893 139324 110416072
Lung disorder 18.20 11.72 17 33886 180030 110375366
Serum procollagen type III N-terminal propeptide increased 18.04 11.72 4 33899 49 110555347
Spinal fracture 18.01 11.72 28 33875 22605 110532791
Pyrexia 17.72 11.72 183 33720 898082 109657314
Phonophobia 17.68 11.72 7 33896 686 110554710
Vision blurred 17.36 11.72 82 33821 128940 110426456
Loss of consciousness 17.17 11.72 111 33792 196195 110359201
Joint range of motion decreased 17.04 11.72 8 33895 121824 110433572
Intentional overdose 16.96 11.72 83 33820 132418 110422978
Therapy interrupted 16.79 11.72 43 33860 49779 110505617
Lactic acidosis 16.61 11.72 4 33899 92807 110462589
Inflammation 16.48 11.72 21 33882 193217 110362179
Therapy cessation 16.47 11.72 40 33863 44817 110510579
Leukopenia 16.31 11.72 13 33890 148778 110406618
Drug interaction 15.98 11.72 89 33814 500094 110055302
Oesophageal stenosis 15.96 11.72 13 33890 5152 110550244
Suicidal ideation 15.93 11.72 64 33839 93873 110461523
Cardiac arrest 15.85 11.72 109 33794 196644 110358752
Drug reaction with eosinophilia and systemic symptoms 15.79 11.72 3 33900 82092 110473304
Facet joint syndrome 15.79 11.72 5 33898 96823 110458573
Hepatic function abnormal 15.69 11.72 4 33899 89291 110466105
Overdose 15.69 11.72 124 33779 233670 110321726
Toxicity to various agents 15.62 11.72 220 33683 480335 110075061
Peripheral vascular disorder 15.53 11.72 16 33887 8560 110546836
Metabolic encephalopathy 15.44 11.72 18 33885 11042 110544354
Wheezing 15.12 11.72 35 33868 255195 110300201
Vitamin B12 deficiency 15.11 11.72 17 33886 10038 110545358
Bronchitis 15.11 11.72 91 33812 156941 110398455
Restless legs syndrome 14.96 11.72 27 33876 24599 110530797
Essential hypertension 14.86 11.72 15 33888 7832 110547564
Malignant neoplasm progression 14.86 11.72 19 33884 174548 110380848
Intentional dose omission 14.82 11.72 24 33879 20056 110535340
Cancer pain 14.80 11.72 14 33889 6758 110548638
Red blood cell sedimentation rate increased 14.77 11.72 3 33900 78299 110477097
Subgaleal haematoma 14.63 11.72 4 33899 121 110555275
Multiple organ dysfunction syndrome 14.55 11.72 15 33888 151695 110403701
Hypersensitivity 14.53 11.72 69 33834 403929 110151467
Obesity 14.50 11.72 71 33832 113280 110442116
Type 2 diabetes mellitus 14.36 11.72 20 33883 177212 110378184
Peripheral venous disease 14.34 11.72 4 33899 84113 110471283
Nausea 14.33 11.72 487 33416 1235203 109320193
Off label use 14.23 11.72 351 33552 1499834 109055562
Rheumatoid arthritis 14.07 11.72 46 33857 299567 110255829
Wound infection 14.01 11.72 6 33897 96459 110458937
Pulmonary pain 13.73 11.72 13 33890 6280 110549116
Gastrointestinal disorder 13.68 11.72 34 33869 241918 110313478
Malabsorption 13.50 11.72 13 33890 6412 110548984
Pain in extremity 13.50 11.72 217 33686 486901 110068495
Grip strength decreased 13.32 11.72 4 33899 80170 110475226
Disease progression 13.25 11.72 35 33868 243999 110311397
Burning sensation 13.24 11.72 49 33854 69163 110486233
Oesophagitis 13.21 11.72 28 33875 28687 110526709
Hypertension 12.95 11.72 224 33679 509860 110045536
Micturition urgency 12.80 11.72 22 33881 19298 110536098
Intervertebral disc displacement 12.74 11.72 5 33898 479 110554917
Seizure 12.55 11.72 113 33790 221072 110334324
Hepatitis 12.46 11.72 6 33897 90048 110465348
Pulmonary fibrosis 12.38 11.72 8 33895 102034 110453362
Fracture nonunion 12.37 11.72 7 33896 1527 110553869
Skin laceration 12.29 11.72 30 33873 33723 110521673
Dizziness 12.20 11.72 290 33613 697903 109857493
Limb injury 12.19 11.72 32 33871 37604 110517792
Skin burning sensation 12.09 11.72 23 33880 21802 110533594
Product dose omission in error 12.08 11.72 24 33879 23488 110531908
Muscle strain 12.06 11.72 16 33887 11186 110544210
Hypermagnesaemia 12.01 11.72 7 33896 1616 110553780
Joint injury 11.94 11.72 33 33870 39961 110515435
Blood lactic acid increased 11.80 11.72 19 33884 15802 110539594

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M03BA03 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Carbamic acid esters
ATC M03BA53 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Carbamic acid esters
ATC M03BA73 MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS
Carbamic acid esters
MeSH PA D009125 Muscle Relaxants, Central
MeSH PA D009465 Neuromuscular Agents
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:51371 muscle relaxant
CHEBI has role CHEBI:62868 hepatoprotective agent
FDA PE N0000175730 Centrally-mediated Muscle Relaxation
FDA EPC N0000175737 Muscle Relaxant

Related Drugs by ATC class:

M03BA Carbamic acid esters 4 drugs
carisoprodolfebarbamatephenprobamatestyramate

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Spasticity indication 221360009
Muscle Spasm with Pain indication
Tetanus Adjunct Treatment indication
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Gastrointestinal ulcer contraindication 40845000
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Acute nephropathy contraindication 58574008
Factor II deficiency contraindication 73975000
Reye's syndrome contraindication 74351001 DOID:14525
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Anemia due to enzyme deficiency contraindication 111577008
von Willebrand disorder contraindication 128105004 DOID:12531
Seizure disorder contraindication 128613002
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Breastfeeding (mother) contraindication 413712001
Acute erosive gastritis contraindication 444926003




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Acute inflammatory and traumatic conditions of the skeletal muscles Indication
Cats Reducing muscular spasms Indication
Dogs Acute inflammatory and traumatic conditions of the skeletal muscles Indication
Dogs Reducing muscular spasms Indication
Horses Acute inflammatory and traumatic conditions of the skeletal muscles Indication
Horses Reducing muscular spasms Indication

🐶 Veterinary products

ProductApplicantIngredients
Robaxin-V Injectable Kinetic Technologies LLC 1
Robaxin-V Tablets Zoetis Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
750MG/5ML ATMEKSI ROSEMONT PHARMS N219843 July 30, 2025 RX SUSPENSION ORAL 12390439 Oct. 9, 2044 ATMEKSI IS INDICATED AS AN ADJUNCT TO REST, PHYSICAL THERAPY, AND OTHER MEASURES FOR THE RELIEF AND DISCOMFORT ASSOCIATED WITH ACUTE, PAINFUL MUSCULOSKELETAL CONDITIONS

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Carbonic anhydrase 1 Enzyme INHIBITOR Ki 7.60 IUPHAR CHEMBL

External reference:

IDSource
4017879 VUID
N0000146232 NUI
D00402 KEGG_DRUG
4017879 VANDF
C0025659 UMLSCUI
CHEBI:6832 CHEBI
CHEMBL1201117 ChEMBL_ID
DB00423 DRUGBANK_ID
D008721 MESH_DESCRIPTOR_UI
4107 PUBCHEM_CID
6829 IUPHAR_LIGAND_ID
776 INN_ID
125OD7737X UNII
6845 RXNORM
5075 MMSL
988 MMSL
d00965 MMSL
001669 NDDF
387486000 SNOMEDCT_US
83973001 SNOMEDCT_US
125OD7737X INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 0276-0510 TABLET, COATED 1000 mg ORAL ANDA 18 sections
METHOCARBAMOL HUMAN PRESCRIPTION DRUG LABEL 1 0404-9992 INJECTION, SOLUTION 1000 mg INTRAVENOUS ANDA 12 sections
METHOCARBAMOL HUMAN PRESCRIPTION DRUG LABEL 1 0404-9992 INJECTION, SOLUTION 1000 mg INTRAVENOUS ANDA 12 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 0440-1740 TABLET 500 mg ORAL ANDA 23 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8506 TABLET, FILM COATED 500 mg ORAL ANDA 18 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8507 TABLET, FILM COATED 750 mg ORAL ANDA 18 sections
ROBAXIN HUMAN PRESCRIPTION DRUG LABEL 1 0641-6103 INJECTION 100 mg INTRAMUSCULAR NDA 22 sections
ROBAXIN HUMAN PRESCRIPTION DRUG LABEL 1 0641-6217 INJECTION 100 mg INTRAMUSCULAR NDA 22 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 0904-7057 TABLET 500 mg ORAL ANDA 22 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 0904-7057 TABLET 500 mg ORAL ANDA 22 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 0904-7058 TABLET 750 mg ORAL ANDA 22 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 0904-7058 TABLET 750 mg ORAL ANDA 22 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 10135-664 TABLET, FILM COATED 500 mg ORAL ANDA 19 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 10135-665 TABLET, FILM COATED 750 mg ORAL ANDA 19 sections
Methocarbamol Tablets, USP, 500 mg HUMAN PRESCRIPTION DRUG LABEL 1 10135-722 TABLET, FILM COATED 500 mg ORAL ANDA 20 sections
Methocarbamol Tablets, USP, 750 mg HUMAN PRESCRIPTION DRUG LABEL 1 10135-723 TABLET, FILM COATED 750 mg ORAL ANDA 20 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 10544-259 TABLET 750 mg ORAL ANDA 21 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 10544-464 TABLET 750 mg ORAL ANDA 22 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 10544-622 TABLET 750 mg ORAL ANDA 19 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 10544-773 TABLET 500 mg ORAL ANDA 22 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 10544-956 TABLET 750 mg ORAL ANDA 23 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 15014-910 TABLET 500 mg ORAL ANDA 20 sections
METHOCARBAMOL HUMAN PRESCRIPTION DRUG LABEL 1 16590-147 TABLET 500 mg ORAL ANDA 21 sections
METHOCARBAMOL HUMAN PRESCRIPTION DRUG LABEL 1 16590-148 TABLET 750 mg ORAL ANDA 21 sections
ROBAXIN HUMAN PRESCRIPTION DRUG LABEL 1 16590-981 TABLET, FILM COATED 750 mg ORAL NDA 11 sections
METHOCARBAMOL HUMAN PRESCRIPTION DRUG LABEL 1 17511-505 TABLET, FILM COATED 500 mg ORAL ANDA 20 sections
METHOCARBAMOL HUMAN PRESCRIPTION DRUG LABEL 1 17511-506 TABLET, FILM COATED 750 mg ORAL ANDA 20 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 21695-078 TABLET 500 mg ORAL ANDA 21 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 21695-079 TABLET 750 mg ORAL ANDA 21 sections
Methocarbamol HUMAN PRESCRIPTION DRUG LABEL 1 25021-675 INJECTION, SOLUTION 100 mg INTRAVENOUS ANDA 23 sections