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metharbital 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| hypnotics, barbituric acid derivatives | 1740 | 50-11-3 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.20 | g | O |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP3K21,MAPK7,NTRK2,PDK1,PRKDC,SIK2,STK33,TEK | 21 | |||
| kinase-selectivity-class | ACVR2B,AXL,BRAF,CAMK2D,CDK4,CDK9,EIF2AK3,GRK2,MAP2K6,MAP3K14,MAPK7,PLK1,PLK2,PLK3,PLK4,STK33,TEK,ULK1 | 18 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA | ABBVIE |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N03AA30 | NERVOUS SYSTEM ANTIEPILEPTICS ANTIEPILEPTICS Barbiturates and derivatives |
| CHEBI has role | CHEBI:35623 | anticonvulsant |
Related Drugs by ATC class:
N03AA Barbiturates and derivatives 4 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Epilepsy | indication | 84757009 | DOID:1826 |
| Insomnia | indication | 193462001 | |
| Tonic-clonic epilepsy | indication | 352818000 | DOID:7725 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.43 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| GABA-A receptor; anion channel | Ion channel | POSITIVE ALLOSTERIC MODULATOR | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018729 | VUID |
| N0000147034 | NUI |
| D01382 | KEGG_DRUG |
| 4018729 | VANDF |
| C0025629 | UMLSCUI |
| CHEBI:31827 | CHEBI |
| VOK | PDB_CHEM_ID |
| CHEMBL450 | ChEMBL_ID |
| DB00463 | DRUGBANK_ID |
| 4099 | PUBCHEM_CID |
| C084822 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7230 | IUPHAR_LIGAND_ID |
| 2 | INN_ID |
| 02OS7K758T | UNII |
| 6825 | RXNORM |
| 001419 | NDDF |
| 30676006 | SNOMEDCT_US |
Pharmaceutical products:
None