aminoquinuride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
quinoline derivatives	174	3811-56-1

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

aminoquinuride
aminochinuride
aminokinuride
aminoquincarbamide
surfen

Molecular weight: 372.43
Formula: C21H20N6O
CLOGP: 4.11
LIPINSKI: 0
HAC: 7
HDO: 4
TPSA: 118.95
ALOGS: -4.53
ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.93	acidic
pKa2	12.51	acidic
pKa3	8.85	Basic
pKa4	8.25	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Matrix metalloproteinase-9	Enzyme	P14780	MMP9_HUMAN		IC50	4		CHEMBL
Interstitial collagenase	Enzyme	P03956	MMP1_HUMAN		IC50	4.51		CHEMBL
Lethal factor	Enzyme		LEF_BACAN		Ki	6.30		CHEMBL
Botulinum neurotoxin type A	Enzyme		BXA1_CLOBO		IC50	5.14		CHEMBL

External reference:

ID	Source
17747	RXNORM
C0051675	UMLSCUI
NSC	PDB_CHEM_ID
CHEMBL87223	ChEMBL_ID
DB04452	DRUGBANK_ID
C010850	MESH_SUPPLEMENTAL_RECORD_UI
71166	PUBCHEM_CID
63	INN_ID
08T7936572	UNII
006338	NDDF

Pharmaceutical products:

None