methanthelinium 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
quaternary ammonium compounds 1736 5818-17-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methanthelinium bromide
  • banthine
  • methantheline
  • methanthelin
  • methanthelinium
  • methantheline bromide
an anticholinergic agent used as an adjunctive therapy in peptic ulcer
  • Molecular weight: 340.44
  • Formula: C21H26NO3
  • CLOGP: 0.57
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 35.53
  • ALOGS: -6.45
  • ROTB: 7

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.15 g O

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
July 3, 1951 FDA SHIRE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A03AB07 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
Synthetic anticholinergics, quaternary ammonium compounds
MeSH PA D018678 Cholinergic Agents
MeSH PA D018680 Cholinergic Antagonists
MeSH PA D018727 Muscarinic Antagonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Urinary incontinence indication 165232002
Gastric ulcer indication 397825006 DOID:10808
Irritable bowel syndrome off-label use 10743008 DOID:9778




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor GPCR ANTAGONIST KEGG DRUG KEGG DRUG

External reference:

IDSource
4019823 VUID
N0000147912 NUI
4018127 VANDF
4019823 VANDF
C0025624 UMLSCUI
CHEBI:6817 CHEBI
CHEMBL1201264 ChEMBL_ID
D00721 KEGG_DRUG
CHEMBL1200988 ChEMBL_ID
DB00940 DRUGBANK_ID
53-46-3 SECONDARY_CAS_RN
4097 PUBCHEM_CID
6821 RXNORM
001731 NDDF
004692 NDDF
21175009 SNOMEDCT_US
2796008 SNOMEDCT_US
D000077771 MESH_DESCRIPTOR_UI
1878 INN_ID
36EI79TX7I UNII

Pharmaceutical products:

None