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methamphetamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1732	537-46-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: methamphetamine (S)-Methamphetamine methylamphetamine D-Methylamphetamine methamphetamine hydrochloride metamfetamine methamphetamine HCl	A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed. Molecular weight: 149.24 Formula: C10H15N CLOGP: 1.89 LIPINSKI: 0 HAC: 1 HDO: 1 TPSA: 12.03 ALOGS: -2.21 ROTB: 3 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

methamphetamine
(S)-Methamphetamine
methylamphetamine
D-Methylamphetamine
methamphetamine hydrochloride
metamfetamine
methamphetamine HCl

A central nervous system stimulant and sympathomimetic with actions and uses similar to DEXTROAMPHETAMINE. The smokable form is a drug of abuse and is referred to as crank, crystal, crystal meth, ice, and speed.

Molecular weight: 149.24
Formula: C10H15N
CLOGP: 1.89
LIPINSKI: 0
HAC: 1
HDO: 1
TPSA: 12.03
ALOGS: -2.21
ROTB: 3

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
15	mg	O

ADMET properties:

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Property	Value	Reference
BA (Bioavailability)	67 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
EoM (Fraction excreted unchanged in urine)	40 %	Benet LZ, Broccatelli F, Oprea TI
CL (Clearance)	4.40 mL/min/kg	Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)	4.30 L/kg	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	12 hours	Lombardo F, Berellini G, Obach RS
S (Water solubility)	1000 mg/mL	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	1.92 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
fu (Fraction unbound in plasma)	0.85 %	Lombardo F, Berellini G, Obach RS
BDDCS (Biopharmaceutical Drug Disposition Classification System)	0	Benet LZ, Broccatelli F, Oprea TI

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Approvals:

Date	Agency	Company	Orphan
Dec. 31, 1943	FDA	RECORDATI RARE

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug abuse	3967.93	49.81	895	2998	71623	63413506
Toxicity to various agents	1298.40	49.81	501	3392	246749	63238380
Completed suicide	565.78	49.81	240	3653	145433	63339696
Cardio-respiratory arrest	255.35	49.81	106	3787	59853	63425276
Respiratory arrest	232.76	49.81	84	3809	32561	63452568
Death	231.72	49.81	187	3706	374194	63110935
Cardiac arrest	223.18	49.81	110	3783	92435	63392694
Amphetamines positive	91.53	49.81	15	3878	187	63484942
Overdose	91.32	49.81	67	3826	115011	63370118
Substance abuse	77.58	49.81	23	3870	4784	63480345

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug abuse	6281.08	59.20	1722	5031	97374	34852804
Toxicity to various agents	1995.46	59.20	890	5863	199472	34750706
Completed suicide	336.28	59.20	218	6535	97950	34852228
Respiratory arrest	315.52	59.20	138	6615	27905	34922273
Cardio-respiratory arrest	266.52	59.20	153	6600	55120	34895058
Cardiac arrest	202.43	59.20	159	6594	96000	34854178
Death	190.46	59.20	301	6452	397748	34552430
Exposure to toxic agent	159.37	59.20	49	6704	3626	34946552
Overdose	138.57	59.20	125	6628	90934	34859244
Prescription drug used without a prescription	134.07	59.20	38	6715	2116	34948062

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug abuse	9985.09	52.25	2539	7786	160152	79573911
Toxicity to various agents	3279.07	52.25	1397	8928	420143	79313920
Completed suicide	814.99	52.25	462	9863	245305	79488758
Respiratory arrest	537.82	52.25	221	10104	57329	79676734
Cardio-respiratory arrest	536.40	52.25	267	10058	108243	79625820
Death	465.29	52.25	460	9865	566054	79168009
Cardiac arrest	408.81	52.25	262	10063	171834	79562229
Overdose	233.68	52.25	192	10133	184014	79550049
Exposure to toxic agent	204.70	52.25	67	10258	9091	79724972
Prescription drug used without a prescription	187.24	52.25	52	10273	4033	79730030

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	N06BA03	NERVOUS SYSTEM PSYCHOANALEPTICS PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS Centrally acting sympathomimetics
CHEBI has role	CHEBI:35337	analeptic
CHEBI has role	CHEBI:35471	psychotropic drugs
CHEBI has role	CHEBI:35703	Xenobiotic
CHEBI has role	CHEBI:50910	agente neurotoxico
CHEBI has role	CHEBI:78298	environmental contaminants
FDA CS	M0001015	Amphetamines
FDA EPC	N0000175425	Amphetamine Anorectic
FDA EPC	N0000175739	Central Nervous System Stimulant
FDA PE	N0000175372	Appetite Suppression

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Attention deficit hyperactivity disorder	indication	406506008
Obesity	indication	414916001	DOID:9970
Gilles de la Tourette's syndrome	contraindication	5158005	DOID:11119
Suicidal thoughts	contraindication	6471006
Dependent drug abuse	contraindication	6525002
Alcoholism	contraindication	7200002
Hyperammonemia	contraindication	9360008
Chronic obstructive lung disease	contraindication	13645005	DOID:3083
Bipolar disorder	contraindication	13746004	DOID:3312
Hepatic encephalopathy	contraindication	13920009	DOID:13413

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.73	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN	INHIBITOR	Ki	7.61	PDSP	CHEMBL
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN		Ki	5.08	CHEMBL
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN	INHIBITOR	Ki	6.13	PDSP
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN	INHIBITOR	Ki	7.91	PDSP
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	5	PDSP
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	6.13	PDSP
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN		Ki	6.09	PDSP
Trace amine-associated receptor 1	GPCR	Q96RJ0	TAAR1_HUMAN	AGONIST	EC50	5.89	CHEMBL
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	5.38	PDSP
Synaptic vesicular amine transporter	Transporter		VMAT2_RAT		Ki	5.61	CHEMBL

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External reference:

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ID	Source
B40	PDB_CHEM_ID
001797	NDDF
004722	NDDF
10836	PUBCHEM_CID
1879	INN_ID
1988	MMSL
387329009	SNOMEDCT_US
387499002	SNOMEDCT_US
4018483	VANDF
4019821	VUID

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Desoxyn	HUMAN PRESCRIPTION DRUG LABEL	1	55292-102	TABLET	5 mg	ORAL	NDA	25 sections
Desoxyn	HUMAN PRESCRIPTION DRUG LABEL	1	55292-104	TABLET	5 mg	ORAL	NDA	25 sections
Desoxyn	HUMAN PRESCRIPTION DRUG LABEL	1	70868-820	TABLET	5 mg	ORAL	NDA	21 sections
Methamphetamine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0389	TABLET	5 mg	ORAL	ANDA	25 sections
Methamphetamine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0054-0389	TABLET	5 mg	ORAL	ANDA	25 sections
Methamphetamine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	68308-115	TABLET	5 mg	ORAL	ANDA	29 sections
Methamphetamine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	68308-115	TABLET	5 mg	ORAL	ANDA	29 sections
Methamphetamine Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	68308-115	TABLET	5 mg	ORAL	ANDA	29 sections

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