metacycline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, protein-synthesis inhibitors, tetracycline derivatives | 1727 | 914-00-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A broad-spectrum semisynthetic antibiotic related to TETRACYCLINE but excreted more slowly and maintaining effective blood levels for a more extended period.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.60 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 58 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| S (Water solubility) | 7.58 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Bocci G, Oprea TI, Benet LZ |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01AA05 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE TETRACYCLINES Tetracyclines |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
| CHEBI has role | CHEBI:36047 | antibacterial drugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Bacterial enteritis | indication | 75375008 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Pregnancy, function | contraindication | 289908002 | |
| Pseudomembranous enterocolitis | contraindication | 397683000 | |
| Breastfeeding (mother) | contraindication | 413712001 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.39 | acidic |
| pKa2 | 7.47 | acidic |
| pKa3 | 9.81 | acidic |
| pKa4 | 10.81 | acidic |
| pKa5 | 12.55 | acidic |
| pKa6 | 13.08 | acidic |
| pKa7 | 8.85 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| NAD-dependent protein deacylase sirtuin-5, mitochondrial | Enzyme | IC50 | 5.44 | CHEMBL | |||||
| DNA repair protein RAD52 homolog | Nuclear other | IC50 | 5.70 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018457 | VUID |
| N0000146781 | NUI |
| D00849 | KEGG_DRUG |
| 3963-95-9 | SECONDARY_CAS_RN |
| 4018457 | VANDF |
| 4019819 | VANDF |
| CHEBI:6805 | CHEBI |
| CHEMBL249837 | ChEMBL_ID |
| CHEMBL2146123 | ChEMBL_ID |
| DB00931 | DRUGBANK_ID |
| 235554 | RXNORM |
| 002747 | NDDF |
| 004863 | NDDF |
| 373527003 | SNOMEDCT_US |
| 50973009 | SNOMEDCT_US |
| 72416006 | SNOMEDCT_US |
| C0025603 | UMLSCUI |
| D008690 | MESH_DESCRIPTOR_UI |
| 1330 | INN_ID |
| 54675785 | PUBCHEM_CID |
| 9GJ0N7ZAP0 | UNII |
Pharmaceutical products:
None