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Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
analogues of penicillanic acid antibiotics modified in the five-membered ring	1709	96036-03-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: meropenem hydrate meropenem merrem meropenem trihydrate	an antibacterial drug readily penetrates the cell wall of most Gram-positive and Gram-negative bacteria to reach penicillin-binding-protein (PBP) targets, the bactericidal activity of meropenem results from the inhibition of cell wall synthesis Molecular weight: 383.46 Formula: C17H25N3O5S CLOGP: -2.29 LIPINSKI: 0 HAC: 8 HDO: 3 TPSA: 110.18 ALOGS: -1.83 ROTB: 5 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

meropenem hydrate
meropenem
merrem
meropenem trihydrate

an antibacterial drug readily penetrates the cell wall of most Gram-positive and Gram-negative bacteria to reach penicillin-binding-protein (PBP) targets, the bactericidal activity of meropenem results from the inhibition of cell wall synthesis

Molecular weight: 383.46
Formula: C17H25N3O5S
CLOGP: -2.29
LIPINSKI: 0
HAC: 8
HDO: 3
TPSA: 110.18
ALOGS: -1.83
ROTB: 5

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
3	g	P
3	g	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	4	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	70 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	111.76 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	0 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.30 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	3.90 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.87 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	1 hours	Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
azlogd74	LogD at pH 7.4	-1.298		High	1
caco2-efflux	Caco-2 efflux ratio (BA/AB)	1.923		High	1
caco2-intrinsic-papp	Caco-2 intrinsic apparent permeability	0.589	10^-6 cm/s	High	1
dh-clint	Dog hepatocyte intrinsic clearance	3.013	uL/min/10^6 cells	High	1
dppb	Dog plasma protein binding (% unbound)	78.170	%	High	1
fcs-ppb	Fetal calf serum protein binding (% unbound)	54.820	%	High	1
herg	hERG pIC50	4.474	pIC50	High	1
hh-clint	Human hepatocyte intrinsic clearance	1.352	uL/min/10^6 cells	High	1
hlm-clint	Human liver microsomal intrinsic clearance	3.681	uL/min/mg protein	High	1
hppb	Human plasma protein binding (% unbound)	63.210	%	High	1
kinase-safety-class	ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK4,CDK5,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,JAK3,MAP2K6,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PRKDC,STK33,SYK,TEK,TGFBR1,ZAP70	28
kinase-selectivity-class	AXL,GRK2,MAP2K6	3
mdck-mdr1-efflux	MDCK-MDR1 efflux ratio	1.493		High	1
mh-clint	Mouse hepatocyte intrinsic clearance	6.209		High	1
mppb	Mouse plasma protein binding (% unbound)	71.760		High	1
nih-mdck-mdr1-efflux	NIH MDCK-MDR1 efflux ratio	2.838		High	1
pfas-class	PFAS structural alert (1 = True, 0 = False)	0
pppb	Pig plasma protein binding (% unbound)	63.850	%	High	1
rh-clint	Rat hepatocyte intrinsic clearance	2.729	uL/min/10^6 cells	High	1
rh-fuinc	Rat hepatocyte fraction unbound in incubation	85.680	%	High	1
rppb	Rat plasma protein binding (% unbound)	60.600	%	High	1
solubility-dd	Solubility at pH 7.4 in DMSO	853.100	uM	High	1

Approvals:

Date	Agency	Company	Orphan
June 21, 1996	FDA	ASTRAZENECA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Multiple organ dysfunction syndrome	952.93	19.84	529	45174	67807	90514937
Septic shock	711.87	19.84	473	45230	83687	90499057
Drug reaction with eosinophilia and systemic symptoms	673.45	19.84	359	45344	42399	90540345
Pathogen resistance	501.74	19.84	179	45524	7936	90574808
Drug resistance	480.30	19.84	256	45447	30193	90552551
Drug ineffective	441.92	19.84	1609	44094	1382689	89200055
Sepsis	434.20	19.84	493	45210	179321	90403423
Respiratory failure	421.73	19.84	400	45303	118018	90464726
Febrile neutropenia	327.11	19.84	401	45302	157948	90424796
Thrombocytopenia	305.97	19.84	447	45256	208278	90374466
Acute kidney injury	286.98	19.84	550	45153	319837	90262907
Systemic candida	278.86	19.84	102	45601	4857	90577887
Pain	266.56	19.84	86	45617	996255	89586489
Off label use	256.29	19.84	1164	44539	1101088	89481656
Haemophagocytic lymphohistiocytosis	235.36	19.84	127	45576	15332	90567412
Joint swelling	226.01	19.84	6	45697	503294	90079450
Toxic epidermal necrolysis	223.34	19.84	161	45542	32367	90550377
Pancytopenia	220.32	19.84	287	45416	119976	90462768
Arthralgia	217.37	19.84	62	45641	778460	89804284
Clostridium difficile colitis	215.63	19.84	146	45557	26560	90556184
Neutropenia	209.67	19.84	393	45310	224511	90358233
Pyrexia	208.77	19.84	768	44935	659717	89923027
Drug ineffective for unapproved indication	208.74	19.84	210	45493	66434	90516310
Fatigue	208.38	19.84	167	45536	1153856	89428888
Dysbiosis	204.26	19.84	62	45641	1640	90581104
Bronchopulmonary aspergillosis	202.99	19.84	104	45599	11294	90571450
Candida infection	198.99	19.84	153	45550	33904	90548840
Eosinophilia	190.81	19.84	139	45564	28394	90554350
Headache	189.28	19.84	100	45603	862646	89720098
Fungaemia	185.01	19.84	68	45635	3282	90579462
Aspergillus infection	184.81	19.84	96	45607	10727	90572017
Abdominal discomfort	184.64	19.84	15	45688	477313	90105431
Enterococcal infection	171.68	19.84	89	45614	9902	90572842
Acute respiratory distress syndrome	167.86	19.84	129	45574	28557	90554187
Drug intolerance	167.85	19.84	16	45687	447575	90135169
Rheumatoid arthritis	163.92	19.84	4	45699	362610	90220134
Mucormycosis	162.16	19.84	64	45639	3757	90578987
Nasopharyngitis	159.63	19.84	12	45691	407092	90175652
Brain abscess	151.31	19.84	56	45647	2756	90579988
Swelling	146.96	19.84	19	45684	419039	90163705
Peripheral swelling	146.65	19.84	18	45685	413088	90169656
Disseminated intravascular coagulation	146.45	19.84	106	45597	21432	90561312
Shock	141.83	19.84	117	45586	28661	90554083
Systemic lupus erythematosus	140.93	19.84	11	45692	361885	90220859
Agranulocytosis	139.43	19.84	126	45577	34876	90547868
Rash maculo-papular	139.31	19.84	135	45568	40798	90541946
Pseudomonas infection	138.78	19.84	89	45614	14776	90567968
Renal impairment	134.68	19.84	212	45491	105209	90477535
Wound	134.46	19.84	4	45699	302976	90279768
Hepatic function abnormal	127.17	19.84	136	45567	46152	90536592
Clostridium test positive	125.22	19.84	59	45644	5342	90577402
Stenotrophomonas infection	123.82	19.84	47	45656	2482	90580262
Candida sepsis	123.48	19.84	42	45661	1611	90581133
Cardiac arrest	123.09	19.84	203	45500	104732	90478012
Acinetobacter infection	122.99	19.84	44	45659	1964	90580780
Linear IgA disease	121.31	19.84	45	45658	2229	90580515
Cytokine release syndrome	119.97	19.84	105	45598	27868	90554876
Alopecia	119.69	19.84	50	45653	495021	90087723
Premature delivery	119.24	19.84	121	45582	38641	90544103
Contraindicated product administered	118.50	19.84	12	45691	320127	90262617
Renal failure	118.30	19.84	226	45477	130781	90451963
Dizziness	118.08	19.84	76	45627	589208	89993536
Stevens-Johnson syndrome	115.53	19.84	105	45598	29271	90553473
Weight increased	115.07	19.84	34	45669	417893	90164851
Fall	112.76	19.84	51	45652	481759	90100985
Therapeutic product effect decreased	112.20	19.84	7	45696	277564	90305180
Pericarditis	111.69	19.84	6	45697	270145	90312599
Drug eruption	109.77	19.84	111	45592	35296	90547448
Sinusitis	107.98	19.84	21	45682	343067	90239677
Musculoskeletal stiffness	107.47	19.84	12	45691	296520	90286224
Infusion related reaction	105.81	19.84	39	45664	416741	90166003
Encephalopathy	104.53	19.84	123	45580	46321	90536423
Klebsiella infection	104.50	19.84	65	45638	10232	90572512
Pain in extremity	103.38	19.84	49	45654	450480	90132264
Muscle spasms	102.87	19.84	6	45697	251877	90330867
Product dose omission issue	102.75	19.84	13	45690	291674	90291070
Leukopenia	102.56	19.84	183	45520	100527	90482217
Bacteraemia	100.26	19.84	86	45617	22214	90560530
Depression	99.81	19.84	16	45687	300585	90282159
Discomfort	99.67	19.84	11	45692	274324	90308420
Pneumonia fungal	99.36	19.84	55	45648	6976	90575768
Clostridium difficile infection	95.18	19.84	104	45599	36141	90546603
Rhinocerebral mucormycosis	94.96	19.84	29	45674	783	90581961
Lactic acidosis	94.77	19.84	122	45581	50341	90532403
Pseudomembranous colitis	91.97	19.84	43	45660	3825	90578919
Coagulopathy	91.10	19.84	83	45620	23206	90559538
Fusarium infection	90.77	19.84	30	45673	1052	90581692
Asthma	89.79	19.84	9	45694	242151	90340593
Blood cholesterol increased	87.94	19.84	4	45699	208008	90374736
Sleep disorder	86.45	19.84	3	45700	198027	90384717
Hypoxia	86.15	19.84	141	45562	72258	90510486
Insomnia	83.28	19.84	32	45671	333442	90249302
Memory impairment	82.71	19.84	4	45699	197240	90385504
Gait disturbance	81.83	19.84	16	45687	260480	90322264
Systemic inflammatory response syndrome	81.35	19.84	47	45656	6469	90576275
Contusion	79.82	19.84	15	45688	251201	90331543
Immune effector cell-associated neurotoxicity syndrome	78.45	19.84	44	45659	5724	90577020
Acute respiratory failure	77.84	19.84	102	45601	42816	90539928
Acute myeloid leukaemia	77.70	19.84	72	45631	20568	90562176
Symmetrical drug-related intertriginous and flexural exanthema	77.56	19.84	26	45677	953	90581791
Toxic skin eruption	77.44	19.84	64	45639	15710	90567034
Weight decreased	76.00	19.84	49	45654	379861	90202883
Haemodynamic instability	75.78	19.84	56	45647	11683	90571061
Staphylococcal bacteraemia	75.42	19.84	47	45656	7422	90575322
Fungal infection	75.23	19.84	100	45603	42561	90540183
Abdominal pain upper	75.02	19.84	37	45666	332637	90250107
Anaemia	74.87	19.84	364	45339	352438	90230306
Platelet count decreased	74.56	19.84	193	45510	136776	90445968
Disseminated mucormycosis	74.38	19.84	23	45680	648	90582096
Oliguria	73.85	19.84	53	45650	10571	90572173
Multiple-drug resistance	73.68	19.84	47	45656	7729	90575015
Dry mouth	73.30	19.84	5	45698	184054	90398690
Intracranial infection	73.00	19.84	18	45685	211	90582533
Asthenia	72.47	19.84	98	45605	533653	90049091
Malaise	72.33	19.84	115	45588	585871	89996873
Folliculitis	72.21	19.84	9	45694	204344	90378400
Myelosuppression	71.51	19.84	110	45593	53481	90529263
Hyperbilirubinaemia	71.47	19.84	58	45645	13878	90568866
Emphysematous pyelonephritis	69.65	19.84	19	45684	339	90582405
Graft versus host disease	69.26	19.84	46	45657	8098	90574646
Procalcitonin increased	69.19	19.84	27	45676	1537	90581207
Protothecosis	68.91	19.84	20	45683	451	90582293
Toxic encephalopathy	68.87	19.84	47	45656	8652	90574092
Impaired healing	68.26	19.84	17	45686	234182	90348562
Migraine	68.22	19.84	8	45695	190384	90392360
Acute generalised exanthematous pustulosis	68.11	19.84	56	45647	13647	90569097
Geotrichum infection	67.80	19.84	21	45682	595	90582149
Hypotension	67.79	19.84	334	45369	325063	90257681
Disease progression	67.78	19.84	203	45500	156412	90426332
Neutropenic sepsis	67.78	19.84	63	45640	18067	90564677
Perinephric abscess	67.36	19.84	18	45685	296	90582448
Drug interaction	66.55	19.84	296	45407	276157	90306587
Anuria	66.31	19.84	57	45646	14761	90567983
Anxiety	66.08	19.84	37	45666	309735	90273009
Staphylococcal infection	65.44	19.84	100	45603	48339	90534405
Cholestasis	65.41	19.84	86	45617	36213	90546531
Pleural effusion	65.31	19.84	162	45541	111829	90470915
Cytomegalovirus infection	64.12	19.84	73	45630	26529	90556215
Ill-defined disorder	63.28	19.84	9	45694	184882	90397862
Metabolic acidosis	62.96	19.84	106	45597	55570	90527174
Arthritis	62.58	19.84	6	45697	167309	90415435
Hepatic failure	62.32	19.84	88	45615	39640	90543104
Musculoskeletal pain	61.84	19.84	7	45696	171244	90411500
Nephropathy toxic	61.29	19.84	51	45652	12637	90570107
Hypersensitivity	61.17	19.84	84	45619	454593	90128151
Pneumonia bacterial	60.93	19.84	51	45652	12739	90570005
Alanine aminotransferase increased	60.58	19.84	163	45540	118175	90464569
Bacterial sepsis	59.90	19.84	35	45668	4920	90577824
Fungal sepsis	59.11	19.84	24	45679	1517	90581227
Mucosal inflammation	59.01	19.84	105	45598	57520	90525224
Pyelonephritis fungal	58.99	19.84	15	45688	201	90582543
Brain oedema	58.50	19.84	57	45646	17328	90565416
Completed suicide	57.58	19.84	4	45699	145054	90437690
Blood lactate dehydrogenase increased	57.22	19.84	68	45635	25864	90556880
Aspartate aminotransferase increased	56.99	19.84	146	45557	102791	90479953
Loss of personal independence in daily activities	56.29	19.84	3	45700	136102	90446642
Drug level decreased	55.26	19.84	43	45660	9687	90573057
Urticaria	55.17	19.84	46	45657	312688	90270056
Trichosporon infection	54.95	19.84	16	45687	365	90582379
Excessive eye blinking	54.80	19.84	22	45681	1350	90581394
Neutropenic colitis	54.71	19.84	31	45672	4112	90578632
Enterococcal sepsis	54.64	19.84	23	45680	1593	90581151
Hepatic infarction	53.48	19.84	18	45685	668	90582076
Seizure	53.46	19.84	184	45519	152445	90430299
Mobility decreased	53.39	19.84	30	45673	250704	90332040
Cytomegalovirus infection reactivation	52.13	19.84	38	45665	7762	90574982
Neurotoxicity	51.89	19.84	59	45644	21408	90561336
Eosinophilic pneumonia	51.40	19.84	26	45677	2747	90579997
Type IV hypersensitivity reaction	50.83	19.84	29	45674	3897	90578847
Peritonitis	50.79	19.84	56	45647	19649	90563095
Neutrophil count decreased	49.90	19.84	111	45592	71421	90511323
Hypoaesthesia	49.76	19.84	51	45652	314159	90268585
Escherichia infection	49.57	19.84	50	45653	15845	90566899
Acute hepatic failure	49.51	19.84	59	45644	22502	90560242
Blood bilirubin increased	49.47	19.84	83	45620	43387	90539357
Cytopenia	49.20	19.84	52	45651	17397	90565347
Mixed liver injury	48.39	19.84	36	45667	7587	90575157
Posterior reversible encephalopathy syndrome	48.34	19.84	58	45645	22281	90560463
Hepatic cytolysis	47.77	19.84	68	45635	30848	90551896
Hypoalbuminaemia	47.74	19.84	49	45654	15848	90566896
Bacterial infection	47.69	19.84	59	45644	23385	90559359
Leukocytosis	47.65	19.84	68	45635	30922	90551822
Night sweats	47.16	19.84	5	45698	128761	90453983
Hyperlactacidaemia	46.81	19.84	28	45675	4108	90578636
Haemorrhagic disorder	46.65	19.84	18	45685	994	90581750
Drug hypersensitivity	46.55	19.84	103	45600	463506	90119238
Urinary tract infection enterococcal	46.52	19.84	25	45678	2991	90579753
Thrombotic microangiopathy	46.33	19.84	48	45655	15695	90567049
Cytomegalovirus viraemia	46.31	19.84	35	45668	7551	90575193
Premature baby	46.09	19.84	60	45643	25017	90557727
Blood pressure increased	45.86	19.84	21	45682	197196	90385548
Pseudomonal sepsis	45.79	19.84	28	45675	4274	90578470
Bone marrow failure	45.62	19.84	68	45635	32153	90550591
Hyperkalaemia	45.53	19.84	101	45602	64863	90517881
Ureaplasma infection	44.96	19.84	17	45686	888	90581856
Vesicoureteric reflux	44.71	19.84	13	45690	295	90582449
Adverse event	44.47	19.84	4	45699	117414	90465330
Foetal anaemia	44.45	19.84	11	45692	131	90582613
Blister	44.36	19.84	38	45665	254960	90327784
Guillain-Barre syndrome	44.00	19.84	28	45675	4584	90578160
Gastrointestinal haemorrhage	43.88	19.84	122	45581	90126	90492618
Nausea	43.62	19.84	355	45348	1109961	89472783
Blood lactate dehydrogenase decreased	43.38	19.84	12	45691	226	90582518
Tumour associated fever	43.37	19.84	14	45689	455	90582289
Pneumocystis jirovecii pneumonia	43.33	19.84	54	45649	21562	90561182
Disseminated aspergillosis	42.66	19.84	14	45689	480	90582264
Respiratory distress	42.51	19.84	73	45630	38873	90543871
Pulmonary haemorrhage	42.47	19.84	34	45669	7979	90574765
Rash morbilliform	42.32	19.84	26	45677	4003	90578741
Hyperchloraemia	41.67	19.84	16	45687	872	90581872
Adverse drug reaction	41.56	19.84	5	45698	116696	90466048
Eosinophilic pneumonia acute	41.29	19.84	15	45688	700	90582044
Pneumonia	41.18	19.84	497	45206	637562	89945182
Anticonvulsant drug level decreased	41.00	19.84	18	45685	1382	90581362
Intentional product use issue	40.64	19.84	30	45673	216862	90365882
Enterococcal bacteraemia	40.49	19.84	20	45683	2008	90580736
Meningitis candida	40.05	19.84	9	45694	68	90582676
Wound infection	39.30	19.84	4	45699	106398	90476346
Joint range of motion decreased	39.21	19.84	10	45693	135633	90447111
Tracheobronchitis	38.86	19.84	18	45685	1567	90581177
Nosocomial infection	38.60	19.84	19	45684	1894	90580850
Transaminases increased	38.37	19.84	68	45635	37124	90545620
Injection site erythema	38.28	19.84	3	45700	98499	90484245
Graft versus host disease in gastrointestinal tract	37.83	19.84	25	45678	4363	90578381
Amnesia	37.78	19.84	5	45698	108500	90474244
Factor V inhibition	37.62	19.84	10	45693	161	90582583
Status epilepticus	37.59	19.84	47	45656	18827	90563917
Weissella infection	37.53	19.84	7	45696	17	90582727
Pancreatitis acute	37.45	19.84	62	45641	32053	90550691
Wheezing	37.28	19.84	39	45664	238041	90344703
Hypertension	37.22	19.84	113	45590	457419	90125325
Nervous system disorder	37.12	19.84	50	45653	21543	90561201
Urinary tract candidiasis	36.90	19.84	14	45689	738	90582006
Coagulation test abnormal	36.82	19.84	15	45688	956	90581788
Polyneuropathy	36.68	19.84	47	45656	19294	90563450
Adenovirus infection	36.65	19.84	25	45678	4597	90578147
Tubulointerstitial nephritis	36.62	19.84	54	45649	25289	90557455
Enterocolitis	36.43	19.84	35	45668	10455	90572289
Brain herniation	36.39	19.84	24	45679	4176	90578568
Hospitalisation	35.98	19.84	10	45693	128090	90454654
Hypernatraemia	35.82	19.84	33	45670	9354	90573390
Stomatitis	35.66	19.84	52	45651	274646	90308098
Intermittent positive pressure breathing	35.65	19.84	8	45695	60	90582684
Feeling abnormal	35.60	19.84	20	45683	167215	90415529
Haemorrhage intracranial	35.51	19.84	41	45662	15121	90567623
Necrotising colitis	35.33	19.84	16	45687	1322	90581422
Pericoronitis	35.30	19.84	9	45694	122	90582622
Aplastic anaemia	34.70	19.84	38	45665	13231	90569513
Meningitis bacterial	34.48	19.84	17	45686	1700	90581044
Acute myeloid leukaemia recurrent	34.41	19.84	18	45685	2039	90580705
Delayed graft function	34.37	19.84	16	45687	1409	90581335
Umbilical erythema	34.36	19.84	8	45695	72	90582672
Acid base balance abnormal	34.33	19.84	11	45692	349	90582395
Clostridial infection	34.23	19.84	24	45679	4612	90578132
Product deposit	34.12	19.84	11	45692	356	90582388
Hepatic enzyme increased	33.89	19.84	83	45620	360653	90222091
Overgrowth fungal	33.79	19.84	9	45694	146	90582598
Graft versus host disease in skin	33.34	19.84	22	45681	3831	90578913
Systemic mycosis	33.29	19.84	16	45687	1514	90581230
Abscess neck	33.18	19.84	13	45690	748	90581996
Venoocclusive liver disease	32.98	19.84	26	45677	5967	90576777
Paraspinal abscess	32.92	19.84	10	45693	265	90582479
Blood alkaline phosphatase increased	32.84	19.84	74	45629	48005	90534739
Liver abscess	32.80	19.84	21	45682	3475	90579269
Pneumothorax	32.37	19.84	44	45659	19123	90563621
Product use in unapproved indication	32.18	19.84	284	45419	335952	90246792
Gastrointestinal disorder	31.95	19.84	50	45653	256637	90326107
Paraesthesia	31.89	19.84	48	45655	250278	90332466
Hepatotoxicity	31.81	19.84	71	45632	45771	90536973
Low birth weight baby	31.78	19.84	31	45672	9436	90573308
Pruritus	31.60	19.84	153	45550	541372	90041372
Renal abscess	31.50	19.84	14	45689	1107	90581637
Tissue infiltration	31.50	19.84	13	45690	857	90581887
Cross sensitivity reaction	31.45	19.84	19	45684	2838	90579906
Encephalitis	31.07	19.84	33	45670	11101	90571643
Hyperhidrosis	30.94	19.84	15	45688	136290	90446454
Diffuse large B-cell lymphoma refractory	30.82	19.84	16	45687	1784	90580960
Inflammatory marker increased	30.61	19.84	30	45673	9184	90573560
Hydrocephalus	30.48	19.84	25	45678	6069	90576675
Device related infection	30.36	19.84	50	45653	25736	90557008
Diabetic macroangiopathy	30.32	19.84	8	45695	125	90582619
Periventricular leukomalacia	30.24	19.84	9	45694	222	90582522
Graft versus host disease in liver	30.22	19.84	13	45690	950	90581794
Blood creatinine increased	30.21	19.84	116	45587	101270	90481474
Haemoperitoneum	30.18	19.84	20	45683	3508	90579236
Ejection fraction decreased	29.70	19.84	50	45653	26203	90556541
Chest pain	29.67	19.84	74	45629	319571	90263173
Central nervous system injury	29.21	19.84	8	45695	145	90582599
Altered state of consciousness	29.17	19.84	55	45648	31477	90551267
Inappropriate schedule of product administration	29.05	19.84	20	45683	149913	90432831
Noninfectious peritonitis	29.00	19.84	8	45695	149	90582595
Cerebral mass effect	28.95	19.84	13	45690	1053	90581691
Drug level increased	28.95	19.84	51	45652	27711	90555033
Gamma-glutamyltransferase increased	28.87	19.84	61	45642	37891	90544853
Dehiscence	28.66	19.84	8	45695	156	90582588
Knee arthroplasty	28.56	19.84	4	45699	83178	90499566
Eosinophil count increased	28.36	19.84	34	45669	13047	90569697
Nocardiosis	28.06	19.84	17	45686	2553	90580191
Tonsillitis bacterial	28.01	19.84	8	45695	170	90582574
Enterobacter infection	27.98	19.84	17	45686	2566	90580178
Stress	27.75	19.84	4	45699	81391	90501353
Epstein-Barr virus infection	27.71	19.84	30	45673	10314	90572430
Metabolic alkalosis	27.68	19.84	19	45684	3530	90579214
Pulmonary sepsis	27.60	19.84	16	45687	2215	90580529
Pseudomonas test positive	27.55	19.84	12	45691	904	90581840
Pseudo-Bartter syndrome	27.51	19.84	7	45696	94	90582650
Interstitial lung disease	27.51	19.84	93	45610	76312	90506432
Gastrooesophageal reflux disease	27.47	19.84	26	45677	166311	90416433
Antibiotic level above therapeutic	27.10	19.84	10	45693	488	90582256
Intentional overdose	26.96	19.84	7	45696	93827	90488917
Oedema peripheral	26.93	19.84	56	45647	257859	90324885
Hyperchlorhydria	26.92	19.84	15	45688	1926	90580818
Splenic injury	26.56	19.84	8	45695	206	90582538
Skin maceration	26.41	19.84	8	45695	210	90582534
Bronchitis	26.33	19.84	23	45680	152904	90429840
Osteoporosis	26.25	19.84	8	45695	96523	90486221
Cytomegalovirus colitis	26.11	19.84	18	45685	3368	90579376
Adjusted calcium decreased	26.06	19.84	8	45695	220	90582524
Complications of transplanted lung	26.03	19.84	9	45694	363	90582381
Abdominal compartment syndrome	25.99	19.84	11	45692	772	90581972
Haemostasis	25.75	19.84	9	45694	375	90582369
Renal graft infection	25.70	19.84	9	45694	377	90582367
Pulmonary fibrosis	25.69	19.84	11	45692	107492	90475252
Wrong technique in product usage process	25.64	19.84	3	45700	71568	90511176
Abscess	25.51	19.84	39	45664	18852	90563892
Immune reconstitution inflammatory syndrome	25.48	19.84	24	45679	6995	90575749
Puncture site haemorrhage	25.43	19.84	9	45694	389	90582355
Klebsiella bacteraemia	25.39	19.84	16	45687	2576	90580168
Cerebral infarction	25.36	19.84	47	45656	26549	90556195
Vulvovaginitis	25.34	19.84	9	45694	393	90582351
Herpes simplex hepatitis	25.32	19.84	10	45693	588	90582156
Adenovirus reactivation	25.24	19.84	8	45695	245	90582499
Neurodevelopmental disorder	25.24	19.84	8	45695	245	90582499
Dyspepsia	25.23	19.84	38	45665	198122	90384622
Endocarditis	25.21	19.84	24	45679	7089	90575655
Cytomegalovirus test positive	25.15	19.84	18	45685	3573	90579171
Myoclonus	25.08	19.84	39	45664	19129	90563615
Relapsing fever	24.90	19.84	8	45695	256	90582488
Ear infection	24.81	19.84	3	45700	69772	90512972
Puncture site haematoma	24.77	19.84	6	45697	65	90582679
Herpes simplex	24.64	19.84	28	45675	10153	90572591
Fluid retention	24.50	19.84	7	45696	88084	90494660
Dry skin	24.50	19.84	7	45696	88066	90494678
Mediastinal effusion	24.28	19.84	6	45697	71	90582673
BK polyomavirus test positive	24.15	19.84	7	45696	157	90582587
Pulseless electrical activity	24.09	19.84	26	45677	8906	90573838
Hypokalaemia	24.05	19.84	130	45573	130986	90451758
Dermatitis exfoliative generalised	23.98	19.84	21	45682	5572	90577172
Septal panniculitis	23.98	19.84	6	45697	75	90582669
Immunosuppression	23.93	19.84	30	45673	12047	90570697
Wound haemorrhage	23.91	19.84	16	45687	2851	90579893
Tracheal injury	23.78	19.84	7	45696	166	90582578
Bronchial anastomosis complication	23.62	19.84	6	45697	80	90582664
Acute graft versus host disease in intestine	23.31	19.84	14	45689	2069	90580675
Hypertransaminasaemia	23.27	19.84	34	45669	15791	90566953
Hepatosplenomegaly	23.21	19.84	16	45687	2993	90579751
White blood cell count decreased	23.17	19.84	154	45549	166955	90415789
Hyperoxaluria	23.10	19.84	7	45696	184	90582560
Generalised tonic-clonic seizure	23.04	19.84	53	45650	34850	90547894
Cardiogenic shock	23.03	19.84	43	45660	24425	90558319
Candida test positive	23.01	19.84	11	45692	1028	90581716
Immunosuppressant drug level increased	22.99	19.84	19	45684	4661	90578083
Imprisonment	22.87	19.84	8	45695	334	90582410
Renal injury	22.83	19.84	27	45676	10216	90572528
Electrolyte imbalance	22.69	19.84	42	45661	23703	90559041
Acidosis	22.67	19.84	30	45673	12706	90570038
Drug-induced liver injury	22.67	19.84	98	45605	90220	90492524
Hyperamylasaemia	22.66	19.84	9	45694	537	90582207
Mycobacterium abscessus infection	22.66	19.84	11	45692	1064	90581680
Hyperaemia	22.65	19.84	15	45688	2627	90580117
Hypochromasia	22.60	19.84	8	45695	346	90582398
Mediastinitis	22.53	19.84	8	45695	349	90582395
Folate deficiency	22.48	19.84	16	45687	3149	90579595
Crystalluria	22.41	19.84	9	45694	553	90582191
Exfoliative rash	22.36	19.84	16	45687	3176	90579568
Neck pain	22.34	19.84	15	45688	113948	90468796
Vision blurred	22.33	19.84	14	45689	110279	90472465
Morganella infection	22.32	19.84	10	45693	806	90581938
Pneumonia pseudomonal	22.31	19.84	16	45687	3187	90579557
Shock haemorrhagic	22.04	19.84	29	45674	12216	90570528
Cardiac tamponade	21.88	19.84	20	45683	5612	90577132
Foetal exposure during pregnancy	21.78	19.84	59	45644	42916	90539828
Blood fibrinogen decreased	21.77	19.84	11	45692	1159	90581585
Hypoglossal nerve paresis	21.69	19.84	6	45697	113	90582631
Pancreatitis necrotising	21.59	19.84	14	45689	2367	90580377
Bronchopulmonary dysplasia	21.50	19.84	9	45694	615	90582129
Apgar score low	21.48	19.84	11	45692	1192	90581552
Globulins decreased	21.45	19.84	8	45695	402	90582342
CNS ventriculitis	21.44	19.84	7	45696	236	90582508
Compartment syndrome	21.33	19.84	15	45688	2897	90579847
Pregnancy	21.26	19.84	3	45700	62044	90520700
Cerebral haemorrhage	21.24	19.84	51	45652	34471	90548273
Osteomyelitis bacterial	21.22	19.84	7	45696	244	90582500
Venoocclusive disease	21.20	19.84	14	45689	2441	90580303
Candida endophthalmitis	21.09	19.84	5	45698	49	90582695
Herpes simplex viraemia	21.08	19.84	8	45695	422	90582322
Tachycardia	21.08	19.84	144	45559	157529	90425215
Condition aggravated	21.01	19.84	419	45284	595126	89987618
Large intestine perforation	20.66	19.84	25	45678	9687	90573057
Sepsis syndrome	20.64	19.84	10	45693	963	90581781
Pneumonia klebsiella	20.61	19.84	15	45688	3057	90579687
Tracheal ulcer	20.59	19.84	4	45699	13	90582731
Hypotonia	20.47	19.84	27	45676	11399	90571345
Prescribed overdose	20.31	19.84	12	45691	97613	90485131
Suicidal ideation	20.30	19.84	6	45697	73849	90508895
Pulmonary hypertensive crisis	20.28	19.84	8	45695	469	90582275
Oropharyngeal pain	20.22	19.84	17	45686	115170	90467574
Arterial perforation	20.15	19.84	4	45699	15	90582729
Pericardial effusion	20.12	19.84	52	45651	36781	90545963
Lung abscess	20.04	19.84	13	45690	2200	90580544

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Multiple organ dysfunction syndrome	759.42	14.98	798	58430	96237	42465870
Drug ineffective	715.51	14.98	2198	57030	627999	41934108
Septic shock	680.17	14.98	733	58495	90939	42471168
Drug resistance	547.73	14.98	422	58806	33826	42528281
Pathogen resistance	488.37	14.98	262	58966	11188	42550919
Drug reaction with eosinophilia and systemic symptoms	475.65	14.98	424	58804	41651	42520456
Fatigue	298.10	14.98	117	59111	435524	42126583
Bronchopulmonary aspergillosis	285.79	14.98	228	59000	19201	42542906
Candida infection	276.81	14.98	234	58994	21376	42540731
Off label use	270.55	14.98	1657	57571	636678	41925429
Drug ineffective for unapproved indication	262.21	14.98	322	58906	45841	42516266
Respiratory failure	249.53	14.98	550	58678	127582	42434525
Systemic candida	247.39	14.98	129	59099	5190	42556917
Enterococcal infection	229.56	14.98	165	59063	11874	42550233
Eosinophilia	229.38	14.98	255	58973	32644	42529463
Sepsis	227.46	14.98	700	58528	198634	42363473
Toxic epidermal necrolysis	215.79	14.98	224	59004	26526	42535581
Pyrexia	213.98	14.98	1095	58133	392947	42169160
Dizziness	202.29	14.98	49	59179	249205	42312902
Disseminated intravascular coagulation	191.73	14.98	203	59025	24591	42537516
Product dose omission issue	180.56	14.98	8	59220	154357	42407750
Fall	179.10	14.98	52	59176	234468	42327639
Haemophagocytic lymphohistiocytosis	173.51	14.98	167	59061	18055	42544052
Hepatic function abnormal	166.84	14.98	275	58953	51292	42510815
Aspergillus infection	160.03	14.98	150	59078	15687	42546420
Klebsiella infection	151.88	14.98	126	59102	11206	42550901
Rash maculo-papular	150.64	14.98	221	59007	37282	42524825
Pancytopenia	138.23	14.98	418	58810	117325	42444782
Pseudomembranous colitis	134.40	14.98	72	59156	3061	42559046
Dysbiosis	133.81	14.98	48	59180	753	42561354
Pseudomonas infection	133.19	14.98	136	59092	15787	42546320
Arthralgia	130.55	14.98	61	59167	205177	42356930
Drug abuse	123.90	14.98	5	59223	104766	42457341
Thrombocytopenia	123.13	14.98	557	58671	189722	42372385
Death	120.91	14.98	301	58927	470884	42091223
Acute respiratory distress syndrome	117.41	14.98	175	59053	29933	42532174
Trichosporon infection	108.04	14.98	43	59185	909	42561198
Drug-induced liver injury	107.82	14.98	192	59036	38081	42524026
Headache	107	14.98	105	59123	239264	42322843
Myocardial infarction	105.23	14.98	22	59206	123987	42438120
Pain	103.13	14.98	113	59115	244735	42317372
Fungal infection	103.01	14.98	132	59096	19590	42542517
Geotrichum infection	97.98	14.98	35	59193	542	42561565
Asthenia	97.29	14.98	150	59078	280643	42281464
Agranulocytosis	97.28	14.98	162	59066	30450	42531657
Inappropriate schedule of product administration	94.96	14.98	11	59217	95891	42466216
Anxiety	94.69	14.98	24	59204	118536	42443571
Clostridium difficile colitis	92.28	14.98	130	59098	21122	42540985
Weight decreased	88.61	14.98	95	59133	207853	42354254
Systemic mycosis	86.28	14.98	49	59179	2338	42559769
Depression	86.17	14.98	24	59204	111339	42450768
Clostridium test positive	86.07	14.98	67	59161	5438	42556669
Drug eruption	85.52	14.98	131	59097	22944	42539163
Cholestasis	85.08	14.98	159	59069	32720	42529387
Nausea	85.04	14.98	276	58952	396523	42165584
Pain in extremity	80.99	14.98	55	59173	150549	42411558
Condition aggravated	79.75	14.98	627	58601	260127	42301980
Mucormycosis	76.69	14.98	70	59158	7073	42555034
Fungaemia	76.38	14.98	50	59178	3086	42559021
Brain abscess	75.49	14.98	56	59172	4228	42557879
Pneumonia bacterial	74.16	14.98	100	59128	15592	42546515
Tachypnoea	73.37	14.98	118	59110	21544	42540563
Blood pressure increased	70.00	14.98	27	59201	101901	42460206
Bone marrow failure	69.90	14.98	147	59081	32946	42529161
Febrile neutropenia	68.43	14.98	467	58761	185236	42376871
Aplastic anaemia	68.01	14.98	85	59143	12299	42549808
Joint swelling	66.83	14.98	8	59220	68014	42494093
Feeling abnormal	66.65	14.98	9	59219	69777	42492330
Renal impairment	66.23	14.98	316	58912	109912	42452195
Rash morbilliform	65.92	14.98	51	59177	4102	42558005
Nasopharyngitis	65.16	14.98	18	59210	83978	42478129
Procalcitonin increased	64.67	14.98	40	59188	2236	42559871
Herpes simplex oesophagitis	64.36	14.98	21	59207	243	42561864
Stenotrophomonas infection	64.34	14.98	48	59180	3656	42558451
Clostridium difficile infection	64.22	14.98	114	59114	22545	42539562
Immune effector cell-associated neurotoxicity syndrome	63.61	14.98	72	59156	9389	42552718
Coagulopathy	63.45	14.98	112	59116	22050	42540057
Dyspnoea	62.80	14.98	360	58868	442261	42119846
Gait disturbance	62.43	14.98	29	59199	97971	42464136
Acinetobacter infection	62.36	14.98	34	59194	1497	42560610
Spinal muscular atrophy	62.30	14.98	23	59205	393	42561714
Weight increased	61.36	14.98	37	59191	107946	42454161
Chest pain	60.22	14.98	63	59165	139467	42422640
Cough	58.90	14.98	98	59130	178005	42384102
Muscle spasms	58.74	14.98	23	59205	86021	42476086
Myelosuppression	58.49	14.98	155	59073	40306	42521801
Hepatic failure	57.16	14.98	148	59080	37952	42524155
Abdominal discomfort	56.76	14.98	17	59211	75238	42486869
Hepatitis cholestatic	56.47	14.98	69	59159	9755	42552352
Hospitalisation	55.68	14.98	17	59211	74313	42487794
Syncope	55.18	14.98	35	59193	99371	42462736
Cardiac failure congestive	55.03	14.98	25	59203	85577	42476530
Shock	54.26	14.98	123	59105	28998	42533109
Hepatomegaly	54.01	14.98	74	59154	11711	42550396
Musculoskeletal stiffness	53.87	14.98	8	59220	57757	42504350
Coronary artery disease	53.56	14.98	6	59222	53714	42508393
Cardiac disorder	52.70	14.98	4	59224	48928	42513179
Injection site pain	51.66	14.98	9	59219	57789	42504318
Acute kidney injury	51.48	14.98	755	58473	366582	42195525
Insomnia	51.46	14.98	53	59175	118200	42443907
Bacteraemia	51.45	14.98	110	59118	24930	42537177
Hyperhidrosis	51.44	14.98	31	59197	90481	42471626
Cytokine release syndrome	51.14	14.98	157	59071	44370	42517737
Conductive deafness	50.60	14.98	21	59207	496	42561611
Pneumonia fungal	50.58	14.98	63	59165	9083	42553024
Pneumococcal sepsis	50.26	14.98	29	59199	1426	42560681
C-reactive protein increased	50.26	14.98	198	59030	63362	42498745
Pruritus	50.23	14.98	118	59110	188653	42373454
Encephalopathy	48.65	14.98	147	59081	41186	42520921
Constipation	48.54	14.98	95	59133	162196	42399911
Intentional product misuse	48.50	14.98	13	59215	61887	42500220
Pulmonary haemorrhage	48.41	14.98	69	59159	11328	42550779
Urinary tract infection fungal	48.24	14.98	21	59207	560	42561547
Liver abscess	48.14	14.98	46	59182	4924	42557183
Chronic obstructive pulmonary disease	48.06	14.98	14	59214	63100	42499007
Incorrect dose administered	47.90	14.98	8	59220	52966	42509141
Methaemoglobinaemia	47.70	14.98	49	59179	5725	42556382
Rheumatoid arthritis	47.07	14.98	3	59225	42437	42519670
Psoriasis	47.05	14.98	6	59222	48598	42513509
Myalgia	46.60	14.98	39	59189	96041	42466066
Hepatotoxicity	46.56	14.98	106	59122	25061	42537046
Sputum increased	46.23	14.98	37	59191	3126	42558981
Cytomegalovirus infection	45.92	14.98	123	59105	32183	42529924
Cerebrovascular accident	45.23	14.98	41	59187	97119	42464988
Back pain	45.03	14.98	80	59148	141696	42420411
Rhinocerebral mucormycosis	44.78	14.98	21	59207	669	42561438
Ototoxicity	44.61	14.98	32	59196	2293	42559814
Neutropenia	44.55	14.98	448	58780	198983	42363124
Liver injury	43.90	14.98	88	59140	19060	42543047
Tumour lysis syndrome	43.78	14.98	96	59132	22135	42539972
Dry mouth	43.69	14.98	3	59225	39876	42522231
Inflammatory marker increased	43.03	14.98	50	59178	6706	42555401
Epilepsy	42.74	14.98	105	59123	26066	42536041
Therapeutic product effect decreased	42.73	14.98	3	59225	39147	42522960
Acute myeloid leukaemia	42.57	14.98	95	59133	22161	42539946
Gastrooesophageal reflux disease	42.53	14.98	6	59222	45017	42517090
Treatment failure	42.39	14.98	186	59042	62438	42499669
Leukopenia	41.80	14.98	210	59018	74536	42487571
Rectal haemorrhage	41.64	14.98	9	59219	49597	42512510
Toxic skin eruption	41.40	14.98	71	59157	13659	42548448
Hyphaema	40.91	14.98	20	59208	700	42561407
Renal failure	40.77	14.98	340	58888	143386	42418721
Dyspnoea exertional	40.30	14.98	10	59218	50138	42511969
Shock haemorrhagic	40.09	14.98	77	59151	16165	42545942
Hypofibrinogenaemia	39.89	14.98	28	59200	1939	42560168
Increased bronchial secretion	39.85	14.98	30	59198	2316	42559791
Sleep disorder	39.82	14.98	9	59219	48086	42514021
Hypoalbuminaemia	39.76	14.98	75	59153	15535	42546572
Strongyloidiasis	39.55	14.98	35	59193	3396	42558711
Wrong technique in product usage process	39.53	14.98	6	59222	42629	42519478
Pseudo-Bartter syndrome	39.42	14.98	9	59219	21	42562086
Motor neurone disease	39.35	14.98	18	59210	541	42561566
Aggression	39.20	14.98	7	59221	44156	42517951
Leukocytosis	39.13	14.98	110	59118	29598	42532509
Pneumothorax	39.02	14.98	95	59133	23448	42538659
Dehydration	39	14.98	87	59141	141680	42420427
Anal inflammation	38.97	14.98	29	59199	2200	42559907
Arthritis	38.82	14.98	6	59222	42059	42520048
Stoma closure	38.78	14.98	15	59213	293	42561814
Vascular pseudoaneurysm thrombosis	38.74	14.98	11	59217	76	42562031
Endocarditis	38.59	14.98	52	59176	8100	42554007
Blood glucose increased	38.15	14.98	28	59200	73671	42488436
Intentional overdose	38.12	14.98	12	59216	51444	42510663
Suicidal ideation	37.94	14.98	10	59218	48151	42513956
SARS-CoV-2 test negative	37.71	14.98	26	59202	1749	42560358
Device related sepsis	37.70	14.98	36	59192	3851	42558256
Platelet count decreased	37.28	14.98	324	58904	138257	42423850
Chest discomfort	37.26	14.98	21	59207	63595	42498512
Vision blurred	37.23	14.98	14	59214	53685	42508422
Hypoaesthesia	37.19	14.98	27	59201	71436	42490671
Product use in unapproved indication	36.78	14.98	405	58823	184051	42378056
Stevens-Johnson syndrome	36.23	14.98	89	59139	22089	42540018
Drug intolerance	36.17	14.98	35	59193	80389	42481718
Hyperbilirubinaemia	36.07	14.98	85	59143	20550	42541557
Fungal endocarditis	36.03	14.98	16	59212	448	42561659
Meningitis candida	36.01	14.98	12	59216	149	42561958
Acute myeloid leukaemia recurrent	34.96	14.98	33	59195	3479	42558628
Anti factor V antibody	34.95	14.98	14	59214	301	42561806
Toxicity to various agents	34.77	14.98	182	59046	228954	42333153
Peripheral swelling	34.36	14.98	45	59183	90225	42471882
Dermatitis bullous	34.17	14.98	50	59178	8406	42553701
Dyspepsia	33.71	14.98	8	59220	41344	42520763
Portal fibrosis	33.68	14.98	14	59214	332	42561775
Cardiac valve vegetation	33.68	14.98	16	59212	525	42561582
Circulatory collapse	33.59	14.98	90	59138	23546	42538561
Multiple-drug resistance	33.59	14.98	46	59182	7276	42554831
Scedosporium infection	33.52	14.98	23	59205	1535	42560572
Venoocclusive liver disease	33.36	14.98	55	59173	10247	42551860
Congenital multiplex arthrogryposis	33.33	14.98	13	59215	260	42561847
Hepatic cytolysis	33.03	14.98	97	59131	26747	42535360
Loss of personal independence in daily activities	32.88	14.98	14	59214	49802	42512305
Device related infection	32.73	14.98	81	59147	20198	42541909
Eosinophilic pneumonia	32.61	14.98	37	59191	4837	42557270
Ischaemic cerebral infarction	32.42	14.98	23	59205	1620	42560487
Enterococcal sepsis	32.22	14.98	25	59203	2019	42560088
Balance disorder	32.07	14.98	13	59215	47632	42514475
CNS ventriculitis	32.00	14.98	14	59214	378	42561729
Hepatic necrosis	31.95	14.98	33	59195	3880	42558227
Hypertension	31.86	14.98	122	59106	167082	42395025
Paraesthesia	31.86	14.98	33	59195	73426	42488681
Neutropenic colitis	31.73	14.98	35	59193	4435	42557672
Oedema peripheral	31.62	14.98	91	59137	135985	42426122
Neurotoxicity	31.56	14.98	88	59140	23563	42538544
Decreased appetite	31.24	14.98	150	59078	192987	42369120
Neonatal candida infection	31.24	14.98	8	59220	35	42562072
Respiratory gas exchange disorder	31.19	14.98	15	59213	506	42561601
Disseminated mucormycosis	31.03	14.98	21	59207	1370	42560737
Neck pain	30.83	14.98	3	59225	30011	42532096
Contusion	30.73	14.98	10	59218	41975	42520132
Transient ischaemic attack	30.71	14.98	5	59223	33734	42528373
Haemodynamic instability	30.34	14.98	59	59169	12498	42549609
Aortoenteric fistula	30.10	14.98	10	59218	123	42561984
Aeromonas infection	29.85	14.98	13	59215	347	42561760
Enterococcus test positive	29.63	14.98	22	59206	1663	42560444
Hypoxia	29.61	14.98	182	59046	69604	42492503
Acute hepatic failure	29.48	14.98	70	59158	17003	42545104
Loss of consciousness	29.41	14.98	52	59176	92302	42469805
Asthma	29.34	14.98	26	59202	62288	42499819
Acute generalised exanthematous pustulosis	29.34	14.98	47	59181	8548	42553559
Epidermolysis bullosa	29.32	14.98	10	59218	134	42561973
Lung consolidation	29.21	14.98	41	59187	6636	42555471
Disseminated cryptococcosis	29.16	14.98	23	59205	1902	42560205
Hyperferritinaemia	29.11	14.98	15	59213	588	42561519
Nocardiosis	29.10	14.98	36	59192	5154	42556953
Mediastinitis	28.77	14.98	18	59210	1027	42561080
Nephrogenic diabetes insipidus	28.69	14.98	21	59207	1553	42560554
Lymphadenectomy	28.69	14.98	14	59214	488	42561619
Cerebral palsy	28.57	14.98	13	59215	386	42561721
Infective aneurysm	28.55	14.98	18	59210	1041	42561066
Mobility decreased	28.45	14.98	7	59221	35299	42526808
Flavobacterium infection	28.33	14.98	9	59219	95	42562012
Staphylococcus test positive	28.12	14.98	30	59198	3662	42558445
Palpitations	28.02	14.98	18	59210	50779	42511328
Heart rate decreased	28.00	14.98	8	59220	36524	42525583
Hypernatraemia	27.81	14.98	50	59178	9982	42552125
Jarisch-Herxheimer reaction	27.73	14.98	16	59212	787	42561320
Megacolon	27.72	14.98	24	59204	2261	42559846
Gingivitis ulcerative	27.61	14.98	11	59217	233	42561874
Intestinal ischaemia	27.59	14.98	48	59180	9340	42552767
Acute respiratory failure	27.50	14.98	117	59111	38741	42523366
Dermatitis exfoliative generalised	27.34	14.98	37	59191	5787	42556320
Respiratory tract infection bacterial	27.20	14.98	22	59206	1887	42560220
Lower respiratory tract infection bacterial	27.14	14.98	14	59214	550	42561557
Haemorrhagic pneumonia	27.13	14.98	10	59218	170	42561937
Cutaneous T-cell lymphoma stage I	26.85	14.98	9	59219	114	42561993
Blood bilirubin increased	26.71	14.98	123	59105	42129	42519978
Blood cholesterol increased	26.62	14.98	3	59225	26738	42535369
Chest X-ray abnormal	26.46	14.98	32	59196	4476	42557631
Anuria	26.43	14.98	53	59175	11479	42550628
Type IV hypersensitivity reaction	26.39	14.98	24	59204	2413	42559694
Bronchial disorder	26.27	14.98	19	59209	1379	42560728
Thrombosis	26.23	14.98	34	59194	68477	42493630
Colitis ulcerative	25.90	14.98	3	59225	26172	42535935
Pneumonia pseudomonal	25.85	14.98	33	59195	4876	42557231
Product prescribing error	25.82	14.98	3	59225	26109	42535998
Blood pressure systolic increased	25.78	14.98	4	59224	27964	42534143
Bacterial sepsis	25.72	14.98	38	59190	6444	42555663
Vomiting	25.69	14.98	268	58960	289455	42272652
Wound dehiscence	25.68	14.98	29	59199	3771	42558336
Cryptococcal meningoencephalitis	25.64	14.98	10	59218	200	42561907
Angina pectoris	25.59	14.98	7	59221	32889	42529218
Somnolence	25.57	14.98	105	59123	141000	42421107
Fungal sepsis	25.57	14.98	17	59211	1077	42561030
Hypokalaemia	25.54	14.98	179	59049	71542	42490565
Cross sensitivity reaction	25.35	14.98	20	59208	1655	42560452
Disease complication	25.26	14.98	26	59202	3044	42559063
Drug level increased	25.22	14.98	87	59141	26113	42535994
Malaise	25.14	14.98	182	59046	211974	42350133
Splenic abscess	25.12	14.98	14	59214	644	42561463
Nephrolithiasis	24.87	14.98	10	59218	36820	42525287
Eosinophilic pneumonia acute	24.85	14.98	15	59213	802	42561305
Drug interaction	24.74	14.98	514	58714	266485	42295622
Discomfort	24.68	14.98	3	59225	25216	42536891
Systemic inflammatory response syndrome	24.67	14.98	40	59188	7350	42554757
Tremor	24.64	14.98	62	59166	96867	42465240
Cardiac arrest	24.57	14.98	246	58982	109074	42453033
Staphylococcal sepsis	24.44	14.98	51	59177	11363	42550744
Influenza like illness	24.35	14.98	7	59221	31833	42530274
Illness	24.31	14.98	3	59225	24927	42537180
Aspergillus test positive	24.29	14.98	14	59214	687	42561420
Amnesia	24.19	14.98	5	59223	28432	42533675
Abdominal pain upper	24.12	14.98	49	59179	82560	42479547
Medication error	24.08	14.98	8	59220	33146	42528961
Hepatitis fulminant	24.03	14.98	32	59196	4927	42557180
Oliguria	24.03	14.98	45	59183	9268	42552839
Serum sickness-like reaction	23.95	14.98	10	59218	240	42561867
Gamma-glutamyltransferase increased	23.89	14.98	99	59129	32398	42529709
Mechanical ventilation	23.83	14.98	22	59206	2255	42559852
Anticonvulsant drug level decreased	23.83	14.98	17	59211	1208	42560899
Infection in an immunocompromised host	23.68	14.98	16	59212	1041	42561066
Osteoarthritis	23.65	14.98	3	59225	24402	42537705
Eczema	23.43	14.98	9	59219	34077	42528030
Swelling	23.41	14.98	25	59203	54860	42507247
Pulmonary mucormycosis	23.38	14.98	18	59210	1437	42560670
Metabolic disorder	23.36	14.98	31	59197	4757	42557350
Linear IgA disease	23.34	14.98	21	59207	2082	42560025
Pneumonia klebsiella	23.17	14.98	29	59199	4200	42557907
Necrotising fasciitis	23.06	14.98	30	59198	4516	42557591
Respiratory paralysis	23.00	14.98	8	59220	114	42561993
Blood alkaline phosphatase increased	22.88	14.98	100	59128	33497	42528610
Staphylococcal infection	22.63	14.98	108	59120	37535	42524572
Microangiopathic haemolytic anaemia	22.50	14.98	16	59212	1131	42560976
Adverse drug reaction	22.43	14.98	12	59216	37422	42524685
Tubulointerstitial nephritis	22.33	14.98	95	59133	31453	42530654
Dysphonia	22.23	14.98	6	59222	28444	42533663
Granulocyte count decreased	22.17	14.98	18	59210	1552	42560555
Enterocolitis	22.00	14.98	45	59183	9884	42552223
COVID-19 pneumonia	21.88	14.98	73	59155	21540	42540567
Metabolic acidosis	21.84	14.98	135	59093	51723	42510384
Soft tissue necrosis	21.81	14.98	11	59217	412	42561695
Obstructive airways disorder	21.81	14.98	4	59224	24755	42537352
Diabetes mellitus	21.81	14.98	31	59197	60056	42502051
Rectal perforation	21.77	14.98	12	59216	540	42561567
Gout	21.77	14.98	6	59222	28049	42534058
Septic embolus	21.75	14.98	17	59211	1388	42560719
Fusarium infection	21.71	14.98	18	59210	1598	42560509
Factor V inhibition	21.36	14.98	9	59219	221	42561886
Blood lactate dehydrogenase increased	21.21	14.98	82	59146	25999	42536108
Cataract	21.17	14.98	8	59220	30596	42531511
Drug dependence	21.16	14.98	7	59221	29087	42533020
Pneumonia	21.12	14.98	750	58478	421399	42140708
Tinnitus	20.99	14.98	7	59221	28931	42533176
Respiratory distress	20.95	14.98	114	59114	41706	42520401
Bacillus infection	20.91	14.98	13	59215	733	42561374
Neuropathy peripheral	20.91	14.98	72	59156	101781	42460326
Rhinorrhoea	20.87	14.98	9	59219	31785	42530322
Pneumonia necrotising	20.76	14.98	15	59213	1087	42561020
Urticaria	20.70	14.98	45	59183	73991	42488116
Drug level decreased	20.69	14.98	44	59184	9933	42552174
Cholangitis infective	20.67	14.98	10	59218	342	42561765
Hyperpyrexia	20.57	14.98	25	59203	3515	42558592
Hepatocellular injury	20.54	14.98	76	59152	23602	42538505
Deep vein thrombosis	20.52	14.98	48	59180	76909	42485198
Pulmonary embolism	20.44	14.98	91	59137	119521	42442586
Interleukin-2 receptor increased	20.02	14.98	8	59220	171	42561936
Hepatitis	19.94	14.98	83	59145	27217	42534890
Resuscitation	19.81	14.98	18	59210	1807	42560300
Toxic encephalopathy	19.72	14.98	35	59193	6918	42555189
Encephalitis	19.70	14.98	41	59187	9117	42552990
Radiation fibrosis - lung	19.69	14.98	5	59223	21	42562086
Cholangiolitis	19.69	14.98	5	59223	21	42562086
Faeces pale	19.68	14.98	17	59211	1597	42560510
Laboratory test abnormal	19.63	14.98	4	59224	22974	42539133
Psychotic disorder	19.61	14.98	8	59220	29200	42532907
Musculoskeletal pain	19.52	14.98	11	59217	33329	42528778
Transaminases increased	19.51	14.98	94	59134	32791	42529316
Vanishing bile duct syndrome	19.43	14.98	18	59210	1853	42560254
Klebsiella bacteraemia	19.41	14.98	20	59208	2344	42559763
Psoas abscess	19.40	14.98	13	59215	834	42561273
Alanine aminotransferase increased	19.40	14.98	198	59030	88208	42473899
Neoplasm malignant	19.34	14.98	4	59224	22739	42539368
Bronchopleural fistula	19.33	14.98	12	59216	675	42561432
Basal cell carcinoma	19.33	14.98	4	59224	22729	42539378
Antinuclear antibody negative	19.32	14.98	5	59223	23	42562084
Muscular weakness	19.27	14.98	56	59172	83442	42478665
Vertigo	19.17	14.98	12	59216	34335	42527772
Fluid retention	19.15	14.98	10	59218	31609	42530498
Disseminated sporotrichosis	19.15	14.98	5	59223	24	42562083
Obliterative bronchiolitis	19.06	14.98	16	59212	1445	42560662
Depressed level of consciousness	19.03	14.98	123	59105	47847	42514260
Peritonitis	18.92	14.98	63	59165	18570	42543537
Escherichia infection	18.90	14.98	46	59182	11350	42550757
Organ failure	18.89	14.98	20	59208	2420	42559687
Catheter site pain	18.85	14.98	17	59211	1690	42560417
Vitamin K deficiency	18.75	14.98	10	59218	421	42561686
Therapy interrupted	18.75	14.98	4	59224	22246	42539861
Angioedema	18.50	14.98	19	59209	42458	42519649
Abdominal compartment syndrome	18.48	14.98	14	59214	1091	42561016
Dermatitis exfoliative	18.47	14.98	34	59194	6913	42555194
Penicillium infection	18.41	14.98	9	59219	315	42561792
Feeling hot	18.26	14.98	5	59223	23477	42538630
Hypoproteinaemia	18.22	14.98	21	59207	2791	42559316
Malignant neoplasm progression	18.21	14.98	83	59145	108317	42453790
Alopecia	18.11	14.98	9	59219	29267	42532840
Cholestatic liver injury	18.08	14.98	24	59204	3685	42558422
Nephropathy toxic	18.06	14.98	58	59170	16780	42545327
Influenza	18.04	14.98	37	59191	62138	42499969
Immune reconstitution inflammatory syndrome	17.96	14.98	42	59186	10101	42552006
Heart rate increased	17.85	14.98	29	59199	53226	42508881
Blood fibrinogen decreased	17.78	14.98	16	59212	1587	42560520
Abdominal pain	17.76	14.98	174	59054	190297	42371810
Red blood cell schistocytes present	17.75	14.98	9	59219	341	42561766
Acoustic neuroma	17.72	14.98	7	59221	145	42561962
Endotracheal intubation	17.69	14.98	24	59204	3761	42558346
Myocardial calcification	17.68	14.98	5	59223	34	42562073
Infectious pleural effusion	17.65	14.98	22	59206	3173	42558934
Abdominal wound dehiscence	17.58	14.98	7	59221	148	42561959
Urinary tract inflammation	17.50	14.98	8	59220	240	42561867
Gait inability	17.50	14.98	5	59223	22828	42539279
Listeriosis	17.48	14.98	15	59213	1396	42560711
Pseudomonal bacteraemia	17.42	14.98	19	59209	2377	42559730
Neuralgia	17.25	14.98	7	59221	25640	42536467
Nosocomial infection	17.25	14.98	15	59213	1421	42560686
Chimerism	17.20	14.98	8	59220	250	42561857
Hypogonadism	17.18	14.98	19	59209	2415	42559692
Hepatic haemorrhage	17.17	14.98	11	59217	654	42561453
Dysarthria	17.12	14.98	18	59210	39789	42522318
Urinary tract candidiasis	17.09	14.98	10	59218	505	42561602
Fungal abscess central nervous system	17.00	14.98	7	59221	162	42561945
Road traffic accident	17.00	14.98	3	59225	19090	42543017
Diarrhoea	16.83	14.98	500	58728	460349	42101758
Flushing	16.78	14.98	16	59212	37012	42525095
Herpes simplex	16.73	14.98	33	59195	7062	42555045
Bilirubin conjugated increased	16.71	14.98	23	59205	3654	42558453
Flatulence	16.70	14.98	7	59221	25145	42536962
Bifidobacterium infection	16.67	14.98	6	59222	95	42562012
Corynebacterium infection	16.59	14.98	12	59216	871	42561236
Acute myocardial infarction	16.55	14.98	35	59193	58130	42503977
Embolic cerebral infarction	16.52	14.98	12	59216	877	42561230
Accidental exposure to product	16.51	14.98	4	59224	20389	42541718
Agitation	16.44	14.98	41	59187	64273	42497834
Pulmonary cavitation	16.44	14.98	14	59214	1290	42560817
Potentiating drug interaction	16.37	14.98	31	59197	6437	42555670
Depressed mood	16.37	14.98	6	59222	23378	42538729
Overdose	16.28	14.98	83	59145	105181	42456926
Pulmonary necrosis	16.25	14.98	9	59219	409	42561698
Graft versus host disease in gastrointestinal tract	16.04	14.98	27	59201	5116	42556991
Immunosuppressant drug level decreased	16.02	14.98	16	59212	1808	42560299
Arterial angioplasty	15.98	14.98	5	59223	50	42562057
Muscle abscess	15.88	14.98	12	59216	932	42561175
Frequent bowel movements	15.84	14.98	5	59223	21402	42540705
Blood culture negative	15.72	14.98	5	59223	53	42562054
Diverticulitis	15.68	14.98	6	59222	22767	42539340
Hypoperfusion	15.53	14.98	14	59214	1391	42560716
Pyroglutamic acidosis	15.51	14.98	11	59217	774	42561333
Therapy non-responder	15.51	14.98	127	59101	53232	42508875
Vascular pseudoaneurysm	15.51	14.98	19	59209	2693	42559414
Burning sensation	15.38	14.98	5	59223	21008	42541099
Pollakiuria	15.37	14.98	6	59222	22499	42539608
Intentional product use issue	15.27	14.98	50	59178	71783	42490324
Cytomegalovirus test positive	15.27	14.98	24	59204	4295	42557812
Skin discolouration	15.24	14.98	5	59223	20885	42541222
Sedation	15.22	14.98	12	59216	30463	42531644
Candida sepsis	15.20	14.98	14	59214	1431	42560676
Alveolitis necrotising	15.18	14.98	4	59224	20	42562087
Haemolysis	15.15	14.98	38	59190	9551	42552556
Urinary retention	15.10	14.98	22	59206	42192	42519915
Pseudomonas test positive	15.05	14.98	14	59214	1449	42560658
Accident	15.04	14.98	30	59198	6473	42555634

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Multiple organ dysfunction syndrome	1657.64	14.92	1247	97959	150463	110339630
Septic shock	1371.80	14.92	1133	98073	156395	110333698
Drug ineffective	1321.51	14.92	3638	95568	1516902	108973191
Drug reaction with eosinophilia and systemic symptoms	1134.63	14.92	779	98427	81316	110408777
Drug resistance	1051.99	14.92	646	98560	55728	110434365
Pathogen resistance	959.87	14.92	416	98790	17256	110472837
Sepsis	627.23	14.92	1083	98123	326263	110163830
Respiratory failure	625.73	14.92	864	98342	214468	110275625
Off label use	493.92	14.92	2641	96565	1497544	108992549
Bronchopulmonary aspergillosis	491.02	14.92	316	98890	29547	110460546
Fatigue	471.66	14.92	253	98953	1215705	109274388
Drug ineffective for unapproved indication	460.32	14.92	513	98693	102325	110387768
Eosinophilia	446.55	14.92	389	98817	57547	110432546
Systemic candida	446.13	14.92	205	99001	9769	110480324
Candida infection	445.85	14.92	359	98847	47650	110442443
Pyrexia	431.75	14.92	1768	97438	896497	109593596
Toxic epidermal necrolysis	423.41	14.92	374	98832	56353	110433740
Thrombocytopenia	416.51	14.92	947	98259	347938	110142155
Enterococcal infection	412.15	14.92	246	98960	20120	110469973
Haemophagocytic lymphohistiocytosis	404.09	14.92	286	98920	31273	110458820
Pain	401.31	14.92	178	99028	954777	109535316
Arthralgia	382.15	14.92	113	99093	779519	109710574
Pancytopenia	354.09	14.92	657	98549	208956	110281137
Headache	345.38	14.92	181	99025	882196	109607897
Aspergillus infection	341.58	14.92	238	98968	25378	110464715
Joint swelling	340.55	14.92	13	99193	442832	110047261
Disseminated intravascular coagulation	338.01	14.92	287	98919	40999	110449094
Dizziness	322.87	14.92	112	99094	698081	109792012
Febrile neutropenia	307.35	14.92	794	98412	315973	110174120
Acute kidney injury	303.11	14.92	1249	97957	634181	109855912
Rash maculo-papular	294.49	14.92	348	98858	73874	110416219
Pseudomonas infection	283.75	14.92	220	98986	27633	110462460
Hepatic function abnormal	282.85	14.92	374	98832	88921	110401172
Fall	278.58	14.92	97	99109	603385	109886708
Clostridium difficile colitis	269.07	14.92	259	98947	43519	110446574
Dysbiosis	262.43	14.92	91	99115	2041	110488052
Acute respiratory distress syndrome	259.89	14.92	278	98928	52920	110437173
Nasopharyngitis	255.28	14.92	28	99178	394333	110095760
Klebsiella infection	248.45	14.92	178	99028	19831	110470262
Rheumatoid arthritis	248.30	14.92	4	99202	299609	110190484
Abdominal discomfort	244.99	14.92	32	99174	393826	110096267
Agranulocytosis	230.93	14.92	281	98925	61479	110428614
Drug intolerance	226.03	14.92	45	99161	406467	110083626
Clostridium test positive	224.09	14.92	133	99073	10760	110479333
Pseudomembranous colitis	223.71	14.92	111	99095	6280	110483813
Mucormycosis	219.25	14.92	130	99076	10498	110479595
Product dose omission issue	218.33	14.92	19	99187	321763	110168330
Neutropenia	215.52	14.92	782	98424	373838	110116255
Brain abscess	214.69	14.92	110	99096	6664	110483429
Pain in extremity	203.80	14.92	91	99115	487027	110003066
Renal impairment	203.18	14.92	492	98714	187953	110302140
Fungaemia	202.12	14.92	102	99104	5984	110484109
Swelling	199.07	14.92	37	99169	351004	110139089
Completed suicide	197.68	14.92	4	99202	242377	110247716
Weight increased	196.02	14.92	66	99140	419578	110070515
Peripheral swelling	195.00	14.92	60	99146	403974	110086119
Acinetobacter infection	190.32	14.92	83	99123	3490	110486603
Clostridium difficile infection	181.73	14.92	229	98977	51900	110438193
Therapeutic product effect decreased	181.66	14.92	9	99197	244307	110245786
Systemic lupus erythematosus	181.05	14.92	12	99194	254326	110235767
Musculoskeletal stiffness	180.69	14.92	20	99186	279802	110210291
Alopecia	179.94	14.92	52	99154	364701	110125392
Wound	179.70	14.92	7	99199	234430	110255663
Depression	174.54	14.92	36	99170	317299	110172794
Drug eruption	173.36	14.92	227	98979	53432	110436661
Fungal infection	170.49	14.92	219	98987	50587	110439506
Cytokine release syndrome	168.71	14.92	258	98948	70048	110420045
Anxiety	163.35	14.92	53	99153	345025	110145068
Muscle spasms	162.74	14.92	27	99179	278130	110211963
Trichosporon infection	161.99	14.92	56	99150	1244	110488849
Geotrichum infection	161.91	14.92	55	99151	1157	110488936
Asthenia	158.52	14.92	233	98973	688766	109801327
Nausea	158.18	14.92	574	98632	1235116	109254977
Immune effector cell-associated neurotoxicity syndrome	153.25	14.92	118	99088	14664	110475429
Dry mouth	153.13	14.92	6	99200	199942	110290151
Infusion related reaction	151.99	14.92	76	99130	381086	110109007
Stenotrophomonas infection	151.34	14.92	83	99123	5775	110484318
Memory impairment	150.52	14.92	6	99200	196938	110293155
Renal failure	150.18	14.92	496	98710	226078	110264015
Coagulopathy	149.45	14.92	184	99022	40727	110449366
Shock	149.31	14.92	211	98995	53377	110436716
Helicobacter infection	148.30	14.92	3	99203	181874	110308219
Cholestasis	148.14	14.92	232	98974	64286	110425807
Encephalopathy	148.02	14.92	263	98943	80792	110409301
Bacteraemia	147.40	14.92	186	99020	42204	110447889
Blood cholesterol increased	143.39	14.92	5	99201	184780	110305313
Pericarditis	143.13	14.92	15	99191	219099	110270994
Pneumonia fungal	142.61	14.92	113	99093	14641	110475452
Discomfort	142.07	14.92	14	99192	214693	110275400
Osteoarthritis	141.51	14.92	5	99201	182618	110307475
Insomnia	139.16	14.92	75	99131	360515	110129578
Leukopenia	137.95	14.92	367	98839	148424	110341669
Cardiac arrest	136.94	14.92	438	98768	196315	110293778
Gait disturbance	136.56	14.92	40	99166	278168	110211925
Contusion	135.72	14.92	23	99183	233338	110256755
Weight decreased	134.40	14.92	133	99073	467924	110022169
Sleep disorder	133.96	14.92	12	99194	198632	110291461
Drug abuse	133.60	14.92	6	99200	177405	110312688
Platelet count decreased	133.15	14.92	482	98724	229961	110260132
Sinusitis	132.78	14.92	50	99156	296638	110193455
Toxic skin eruption	131.21	14.92	142	99064	27373	110462720
Hepatic failure	129.34	14.92	226	98980	68513	110421580
Asthma	128.44	14.92	33	99173	250258	110239835
Blood pressure increased	127.08	14.92	37	99169	258336	110231757
Linear IgA disease	126.85	14.92	67	99139	4322	110485771
Stevens-Johnson syndrome	126.73	14.92	182	99024	46719	110443374
Abdominal pain upper	125.65	14.92	79	99127	349032	110141061
Migraine	125.46	14.92	7	99199	171645	110318448
Injection site pain	124.84	14.92	9	99197	177913	110312180
Type 2 diabetes mellitus	124.26	14.92	9	99197	177223	110312870
Systemic mycosis	120.83	14.92	62	99144	3767	110486326
Multiple-drug resistance	120.76	14.92	98	99108	13137	110476956
Myelosuppression	120.00	14.92	263	98943	94077	110396016
Malaise	119.69	14.92	266	98940	671553	109818540
Bone marrow failure	117.80	14.92	197	99009	57651	110432442
Pneumonia bacterial	117.38	14.92	131	99075	26130	110463963
Rhinocerebral mucormycosis	113.81	14.92	45	99161	1472	110488621
Arthritis	113.33	14.92	10	99196	167576	110322517
Hypoaesthesia	113.21	14.92	71	99135	314152	110175941
Procalcitonin increased	111.82	14.92	60	99146	3996	110486097
Mobility decreased	111.38	14.92	37	99169	237385	110252708
Rash morbilliform	110.98	14.92	76	99130	7875	110482218
Cytomegalovirus infection	110.32	14.92	185	99021	54259	110435834
Musculoskeletal pain	108.74	14.92	17	99189	183006	110307087
Folliculitis	108.15	14.92	12	99194	167641	110322452
Drug interaction	107.89	14.92	793	98413	499390	109990703
Aplastic anaemia	104.79	14.92	119	99087	24189	110465904
Acute myeloid leukaemia	104.60	14.92	149	99057	37961	110452132
Ill-defined disorder	104.35	14.92	10	99196	156843	110333250
Urticaria	103.05	14.92	81	99125	318776	110171317
Leukocytosis	99.99	14.92	176	99030	53652	110436441
Drug-induced liver injury	99.22	14.92	284	98922	119783	110370310
Impaired healing	98.89	14.92	27	99179	196690	110293403
Psoriasis	98.45	14.92	7	99199	139986	110350107
Gait inability	98.32	14.92	6	99200	136370	110353723
Feeling abnormal	98.29	14.92	21	99185	180690	110309403
Tachypnoea	97.94	14.92	147	99059	39248	110450845
Systemic inflammatory response syndrome	97.27	14.92	86	99120	12957	110477136
Acute respiratory failure	97.06	14.92	211	98995	75049	110415044
Inappropriate schedule of product administration	96.81	14.92	31	99175	203606	110286487
Contraindicated product administered	96.68	14.92	51	99155	248216	110241877
Fusarium infection	96.61	14.92	48	99158	2723	110487370
Disseminated mucormycosis	96.49	14.92	44	99162	2058	110488035
Muscle injury	96.31	14.92	8	99198	140799	110349294
Hypoalbuminaemia	95.79	14.92	124	99082	28850	110461243
Acute generalised exanthematous pustulosis	94.99	14.92	107	99099	21557	110468536
Hyperbilirubinaemia	93.28	14.92	126	99080	30545	110459548
Hypoxia	92.52	14.92	291	98915	129224	110360869
Paraesthesia	92.22	14.92	68	99138	276453	110213640
Staphylococcal infection	91.23	14.92	197	99009	69747	110420346
Candida sepsis	90.71	14.92	47	99159	2914	110487179
Hypersensitivity	90.46	14.92	139	99067	403859	110086234
Neutropenic colitis	89.38	14.92	67	99139	7998	110482095
Drug hypersensitivity	88.20	14.92	171	99035	453919	110036174
Haemodynamic instability	86.93	14.92	105	99101	22783	110467310
Pneumothorax	86.77	14.92	131	99075	35154	110454939
Neurotoxicity	84.95	14.92	143	99063	42064	110448029
Loss of personal independence in daily activities	84.58	14.92	16	99190	150004	110340089
Injury	84.23	14.92	27	99179	177238	110312855
Oliguria	83.26	14.92	93	99113	18564	110471529
Liver abscess	82.90	14.92	63	99143	7676	110482417
Pruritus	82.39	14.92	258	98948	581302	109908791
Obesity	81.67	14.92	5	99201	113346	110376747
Myocardial infarction	81.62	14.92	35	99171	192048	110298045
Chest pain	80.94	14.92	133	99073	376242	110113851
Enterococcal sepsis	80.28	14.92	45	99161	3267	110486826
Eosinophilic pneumonia	80.01	14.92	60	99146	7167	110482926
Road traffic accident	79.66	14.92	4	99202	107394	110382699
Suicide attempt	79.50	14.92	3	99203	103391	110386702
Gastrooesophageal reflux disease	79.38	14.92	31	99175	179945	110310148
Hypertension	78.98	14.92	217	98989	509867	109980226
Hepatic cytolysis	78.71	14.92	161	99045	54892	110435201
Inflammatory marker increased	78.49	14.92	80	99126	14389	110475704
Dyspnoea	76.53	14.92	631	98575	1106241	109383852
Hepatitis cholestatic	75.73	14.92	86	99120	17480	110472613
Pulmonary haemorrhage	75.11	14.92	83	99123	16373	110473720
Stress	74.85	14.92	5	99201	105343	110384750
Metabolic acidosis	74.84	14.92	228	98978	99516	110390577
Anuria	74.03	14.92	100	99106	24241	110465852
Blood lactate dehydrogenase increased	73.51	14.92	138	99068	44196	110445897
Toxic encephalopathy	73.38	14.92	79	99127	15135	110474958
Type IV hypersensitivity reaction	73.35	14.92	53	99153	5980	110484113
Nephropathy toxic	73.30	14.92	106	99100	27372	110462721
Acute hepatic failure	72.65	14.92	123	99083	36345	110453748
Intracranial infection	71.93	14.92	22	99184	326	110489767
Spinal muscular atrophy	71.57	14.92	23	99183	404	110489689
Dry skin	71.24	14.92	7	99199	107646	110382447
Pneumonia	71.06	14.92	1142	98064	875572	109614521
Tumour lysis syndrome	71.02	14.92	111	99095	30690	110459403
Joint range of motion decreased	70.83	14.92	12	99194	121820	110368273
Drug level decreased	70.29	14.92	85	99121	18463	110471630
Lung consolidation	70.12	14.92	65	99141	10411	110479682
Condition aggravated	69.93	14.92	984	98222	733852	109756241
Hepatotoxicity	69.82	14.92	167	99039	63233	110426860
Shock haemorrhagic	69.63	14.92	103	99103	27144	110462949
Staphylococcal bacteraemia	69.07	14.92	80	99126	16608	110473485
Hospitalisation	68.95	14.92	21	99185	142472	110347621
Dyspepsia	68.95	14.92	43	99163	190922	110299171
Drug level increased	68.75	14.92	140	99066	47579	110442514
Tubulointerstitial nephritis	68.63	14.92	151	99055	54133	110435960
Blood bilirubin increased	67.97	14.92	185	99021	75787	110414306
Hyperhidrosis	67.87	14.92	42	99164	187256	110302837
Product use in unapproved indication	67.51	14.92	655	98551	446722	110043371
Pleural effusion	67.49	14.92	327	98879	177382	110312711
Intentional overdose	66.94	14.92	18	99188	132483	110357610
Gastrointestinal disorder	66.82	14.92	71	99135	241881	110248212
Device related infection	66.75	14.92	124	99082	39395	110450698
Escherichia infection	66.66	14.92	94	99112	23722	110466371
Bacterial sepsis	66.54	14.92	63	99143	10363	110479730
Night sweats	66.20	14.92	19	99187	133964	110356129
Meningitis candida	65.95	14.92	19	99187	226	110489867
Anticonvulsant drug level decreased	65.71	14.92	34	99172	2102	110487991
Herpes simplex oesophagitis	65.70	14.92	22	99184	442	110489651
Endocarditis	65.49	14.92	70	99136	13301	110476792
Injection site erythema	65.38	14.92	5	99201	94171	110395922
Respiratory distress	64.92	14.92	171	99035	68703	110421390
Anaemia	64.84	14.92	763	98443	546323	109943770
Premature delivery	64.61	14.92	106	99100	30526	110459567
Stomatitis	64.36	14.92	89	99117	270153	110219940
Injection site reaction	63.95	14.92	4	99202	89066	110401027
Nocardiosis	63.22	14.92	53	99153	7433	110482660
Intentional product use issue	62.77	14.92	78	99128	247828	110242265
Amnesia	62.13	14.92	10	99196	105398	110384695
Wound infection	61.97	14.92	7	99199	96458	110393635
Wheezing	61.85	14.92	83	99123	255147	110234946
Neck pain	61.69	14.92	17	99189	123113	110366980
Eosinophilic pneumonia acute	61.50	14.92	30	99176	1635	110488458
Fungal sepsis	61.41	14.92	33	99173	2204	110487889
Illness	61.13	14.92	3	99203	82168	110407925
Peritonitis	61.05	14.92	107	99099	32500	110457593
Acute myeloid leukaemia recurrent	59.88	14.92	44	99162	5095	110484998
Perinephric abscess	59.49	14.92	20	99186	407	110489686
Alanine aminotransferase increased	59.23	14.92	323	98883	183450	110306643
Ototoxicity	58.87	14.92	40	99166	4091	110486002
Scedosporium infection	58.50	14.92	33	99173	2425	110487668
Brain oedema	58.16	14.92	102	99104	30996	110459097
Venoocclusive liver disease	58.13	14.92	70	99136	15137	110474956
Protothecosis	58.01	14.92	21	99185	536	110489557
Cough	57.73	14.92	216	98990	461425	110028668
Vision blurred	57.26	14.92	22	99184	129000	110361093
Emphysematous pyelonephritis	57.25	14.92	21	99185	557	110489536
Factor V inhibition	56.73	14.92	19	99187	382	110489711
Hyphaema	56.64	14.92	25	99181	1082	110489011
Strongyloidiasis	56.55	14.92	42	99164	4944	110485149
Enterocolitis	56.34	14.92	77	99129	18872	110471221
Transaminases increased	56.34	14.92	154	99052	63236	110426857
Myalgia	56.27	14.92	70	99136	222311	110267782
Neutrophil count decreased	55.98	14.92	236	98970	120705	110369388
Disease progression	55.44	14.92	392	98814	243642	110246451
Syncope	55.29	14.92	60	99146	202476	110287617
Graft versus host disease in gastrointestinal tract	54.97	14.92	53	99153	8915	110481178
Symmetrical drug-related intertriginous and flexural exanthema	54.94	14.92	29	99177	1868	110488225
Wrong technique in product usage process	54.48	14.92	7	99199	87341	110402752
Mediastinitis	53.90	14.92	26	99180	1382	110488711
Neutropenic sepsis	53.85	14.92	98	99108	30648	110459445
Hypernatraemia	53.83	14.92	73	99133	17760	110472333
Vomiting	53.77	14.92	540	98666	910135	109579958
Oedema peripheral	53.73	14.92	136	99070	328524	110161569
Circulatory collapse	53.68	14.92	119	99087	42874	110447219
Pneumococcal sepsis	53.47	14.92	30	99176	2182	110487911
Blood pressure systolic increased	53.36	14.92	6	99200	82985	110407108
Dermatitis bullous	53.28	14.92	72	99134	17457	110472636
Dermatitis exfoliative generalised	52.97	14.92	57	99149	10915	110479178
Adverse event	52.71	14.92	16	99190	108793	110381300
Hypofibrinogenaemia	52.58	14.92	31	99175	2476	110487617
Gamma-glutamyltransferase increased	52.56	14.92	147	99059	61162	110428931
Lower limb fracture	52.30	14.92	4	99202	75344	110414749
Nasal congestion	52.26	14.92	12	99194	98270	110391823
Mixed liver injury	51.83	14.92	59	99147	12020	110478073
Urinary tract candidiasis	51.60	14.92	24	99182	1175	110488918
Intentional product misuse	50.70	14.92	28	99178	132876	110357217
Megacolon	50.48	14.92	37	99169	4268	110485825
Nosocomial infection	50.47	14.92	33	99173	3166	110486927
Adverse drug reaction	50.28	14.92	16	99190	105543	110384550
Back pain	50.10	14.92	168	99038	370828	110119265
Hypotension	49.95	14.92	702	98504	523147	109966946
Blood alkaline phosphatase increased	49.37	14.92	158	99048	70777	110419316
Sputum increased	49.15	14.92	41	99165	5710	110484383
Hepatomegaly	49.13	14.92	77	99129	21337	110468756
Hyperlactacidaemia	48.97	14.92	48	99158	8238	110481855
Pneumonia pseudomonal	48.92	14.92	46	99160	7500	110482593
Seizure	48.90	14.92	353	98853	220832	110269261
Product quality issue	48.68	14.92	6	99200	77293	110412800
Anti factor V antibody	48.52	14.92	16	99190	306	110489787
Cardiac failure congestive	47.95	14.92	39	99167	150961	110339132
Constipation	47.64	14.92	163	99043	357623	110132470
Incorrect dose administered	47.12	14.92	17	99189	103624	110386469
Chest discomfort	46.90	14.92	52	99154	173796	110316297
Autoimmune disorder	46.84	14.92	3	99203	65480	110424613
COVID-19 pneumonia	46.59	14.92	103	99103	37040	110453053
Decreased appetite	46.57	14.92	244	98962	475602	110014491
Encephalitis	46.40	14.92	70	99136	18769	110471324
Heart rate decreased	46.27	14.92	9	99197	82747	110407346
Cerebrovascular accident	45.92	14.92	57	99149	181227	110308866
Immune reconstitution inflammatory syndrome	45.35	14.92	64	99142	16162	110473931
Anal inflammation	44.97	14.92	28	99178	2468	110487625
Red blood cell sedimentation rate increased	44.88	14.92	8	99198	78294	110411799
Pseudo-Bartter syndrome	44.87	14.92	12	99194	106	110489987
Ear infection	44.49	14.92	3	99203	62729	110427364
Pyelonephritis fungal	44.36	14.92	15	99191	311	110489782
Pneumocystis jirovecii pneumonia	44.31	14.92	110	99096	42625	110447468
Klebsiella bacteraemia	44.31	14.92	36	99170	4833	110485260
CNS ventriculitis	44.19	14.92	18	99188	637	110489456
Staphylococcus test positive	44.13	14.92	43	99163	7327	110482766
Dyspnoea exertional	44.13	14.92	19	99187	104041	110386052
Urinary tract infection fungal	43.87	14.92	22	99184	1273	110488820
Fluid retention	43.68	14.92	15	99191	94292	110395801
Muscular weakness	43.63	14.92	99	99107	248369	110241724
Knee arthroplasty	43.56	14.92	4	99202	64944	110425149
SARS-CoV-2 test negative	43.53	14.92	26	99180	2127	110487966
Suicidal ideation	43.40	14.92	15	99191	93922	110396171
Rhinorrhoea	43.14	14.92	19	99187	102647	110387446
Vascular pseudoaneurysm thrombosis	43.02	14.92	11	99195	80	110490013
Blister	42.91	14.92	87	99119	227289	110262804
Motor neurone disease	42.45	14.92	18	99188	706	110489387
Bronchitis	42.32	14.92	47	99159	156985	110333108
Graft versus host disease	42.29	14.92	67	99139	18739	110471354
Cardiac valve vegetation	42.24	14.92	20	99186	1020	110489073
Pneumonia klebsiella	42.18	14.92	40	99166	6592	110483501
Vesicoureteric reflux	42.17	14.92	13	99193	198	110489895
Cross sensitivity reaction	42.10	14.92	37	99169	5530	110484563
Pseudomonal sepsis	41.93	14.92	46	99160	9000	110481093
Osteoporosis	41.88	14.92	13	99193	87139	110402954
Coronary artery disease	41.80	14.92	7	99199	71683	110418410
Blood creatinine increased	41.65	14.92	294	98912	182595	110307498
Frequent bowel movements	41.56	14.92	7	99199	71383	110418710
Unevaluable event	41.52	14.92	3	99203	59224	110430869
Methaemoglobinaemia	41.42	14.92	46	99160	9122	110480971
Pseudomonas test positive	41.39	14.92	26	99180	2328	110487765
Lactic acidosis	41.32	14.92	179	99027	92632	110397461
Prescribed underdose	41.19	14.92	5	99201	65169	110424924
Device related sepsis	40.97	14.92	42	99164	7605	110482488
Brain herniation	40.96	14.92	45	99161	8818	110481275
Infective aneurysm	40.93	14.92	22	99184	1470	110488623
Blood fibrinogen decreased	40.76	14.92	27	99179	2648	110487445
Enterococcal bacteraemia	40.63	14.92	33	99173	4428	110485665
Stoma closure	40.61	14.92	15	99191	406	110489687
Hepatitis fulminant	40.50	14.92	44	99162	8516	110481577
Increased bronchial secretion	39.80	14.92	31	99175	3917	110486176
Balance disorder	39.70	14.92	28	99178	116532	110373561
Necrotising fasciitis	39.42	14.92	41	99165	7550	110482543
Rectal haemorrhage	39.24	14.92	30	99176	119803	110370290
Bacterial infection	39.09	14.92	110	99096	45926	110444167
Medication error	39.04	14.92	23	99183	105343	110384750
Flavobacterium infection	38.64	14.92	11	99195	125	110489968
Hypokalaemia	38.50	14.92	288	98918	182160	110307933
Immunosuppressant drug level increased	38.48	14.92	50	99156	11674	110478419
Lung disorder	38.32	14.92	64	99142	179983	110310110
Abdominal compartment syndrome	38.26	14.92	23	99183	1904	110488189
Cytomegalovirus viraemia	38.18	14.92	62	99144	17702	110472391
Nephrogenic diabetes insipidus	38.03	14.92	25	99181	2420	110487673
Herpes simplex	38.01	14.92	58	99148	15706	110474387
Infectious pleural effusion	37.98	14.92	33	99173	4858	110485235
Cataract	37.94	14.92	12	99194	79473	110410620
Blepharospasm	37.82	14.92	3	99203	54848	110435245
Abscess	37.69	14.92	79	99127	27390	110462703
White blood cell count decreased	37.61	14.92	342	98864	229048	110261045
Aspartate aminotransferase increased	37.53	14.92	259	98947	159677	110330416
Depressed level of consciousness	37.28	14.92	199	99007	112079	110378014
Hepatic infarction	37.21	14.92	18	99188	963	110489130
Urinary tract infection enterococcal	37.17	14.92	29	99177	3673	110486420
Haemoperitoneum	37.17	14.92	34	99172	5354	110484739
Lower respiratory tract infection	37.14	14.92	104	99102	243002	110247091
Hepatosplenomegaly	37.07	14.92	38	99168	6881	110483212
Meningitis bacterial	36.85	14.92	27	99179	3112	110486981
Fungal endocarditis	36.81	14.92	17	99189	819	110489274
Staphylococcal sepsis	36.27	14.92	60	99146	17394	110472699
Thrombotic microangiopathy	35.62	14.92	80	99126	29069	110461024
Cytomegalovirus infection reactivation	35.41	14.92	61	99145	18272	110471821
Feeling hot	35.03	14.92	19	99187	91087	110399006
Serum ferritin increased	35.01	14.92	48	99158	11799	110478294
Pregnancy	34.64	14.92	3	99203	51064	110439029
Blood pressure fluctuation	34.48	14.92	12	99194	74812	110415281
Organ failure	34.41	14.92	31	99175	4786	110485307
Dehydration	34.12	14.92	132	99074	279379	110210714
Multiple sclerosis relapse	33.95	14.92	3	99203	50237	110439856
Disseminated cryptococcosis	33.81	14.92	24	99182	2633	110487460
Exfoliative rash	33.79	14.92	30	99176	4544	110485549
Excessive eye blinking	33.75	14.92	21	99185	1849	110488244
Aeromonas infection	33.66	14.92	14	99192	523	110489570
Hepatic necrosis	33.64	14.92	43	99163	9879	110480214
Dermatitis exfoliative	33.57	14.92	46	99160	11301	110478792
Dry eye	33.54	14.92	5	99201	55788	110434305
Weissella infection	33.51	14.92	7	99199	17	110490076
Palpitations	33.50	14.92	57	99149	159155	110330938
Hepatic enzyme increased	33.39	14.92	161	99045	320731	110169362
Respiratory paralysis	33.35	14.92	10	99196	138	110489955
Graft versus host disease in skin	33.21	14.92	39	99167	8215	110481878
Posterior reversible encephalopathy syndrome	32.86	14.92	85	99121	33776	110456317
Aortoenteric fistula	32.64	14.92	10	99196	149	110489944
Hypoproteinaemia	32.48	14.92	33	99173	5912	110484181
Confusional state	32.33	14.92	267	98939	468413	110021680
Burning sensation	32.06	14.92	11	99195	69201	110420892
Injection site swelling	31.96	14.92	8	99198	61782	110428311
Enterococcus test positive	31.90	14.92	24	99182	2880	110487213
C-reactive protein increased	31.80	14.92	317	98889	217602	110272491
Eosinophil count increased	31.78	14.92	63	99143	20995	110469098
Candida test positive	31.73	14.92	18	99188	1337	110488756
Interstitial lung disease	31.72	14.92	224	98982	139110	110350983
Ischaemic cerebral infarction	31.60	14.92	24	99182	2921	110487172
Tumour associated fever	31.52	14.92	17	99189	1144	110488949
Intestinal ischaemia	31.47	14.92	54	99152	16125	110473968
Colitis ulcerative	31.44	14.92	15	99191	77348	110412745
Status epilepticus	31.41	14.92	80	99126	31491	110458602
Blood glucose increased	31.16	14.92	44	99162	132452	110357641
Respiratory tract infection bacterial	31.16	14.92	22	99184	2394	110487699
Splenic abscess	31.00	14.92	16	99190	984	110489109
Mucosal inflammation	30.97	14.92	169	99037	95972	110394121
Pancreatitis necrotising	30.91	14.92	31	99175	5470	110484623
Influenza	30.81	14.92	66	99140	169035	110321058
Hyperamylasaemia	30.71	14.92	17	99189	1204	110488889
Bronchial disorder	30.62	14.92	23	99183	2753	110487340
Joint stiffness	30.61	14.92	11	99195	67232	110422861
Hydrocephalus	30.60	14.92	42	99164	10333	110479760
Haemorrhagic pneumonia	30.59	14.92	10	99196	186	110489907
Live birth	30.57	14.92	12	99194	69472	110420621
Upper respiratory tract infection	30.50	14.92	44	99162	131284	110358809
Somnolence	30.50	14.92	150	99056	297299	110192794
Adenovirus infection	30.18	14.92	43	99163	10951	110479142
Transient ischaemic attack	29.93	14.92	10	99196	63972	110426121
Hyperferritinaemia	29.80	14.92	16	99190	1067	110489026
Pneumonia necrotising	29.70	14.92	19	99187	1756	110488337
Renal abscess	29.42	14.92	18	99188	1538	110488555
Adenovirus reactivation	29.35	14.92	14	99192	726	110489367
Haemorrhagic disorder	29.33	14.92	19	99187	1794	110488299
Gastrointestinal haemorrhage	29.31	14.92	251	98955	165267	110324826
Taste disorder	29.26	14.92	11	99195	65376	110424717
Clostridial infection	29.13	14.92	32	99174	6270	110483823
Pancreatitis acute	28.96	14.92	119	99087	60155	110429938
Cutaneous T-cell lymphoma stage I	28.90	14.92	9	99197	142	110489951
Accidental exposure to product	28.90	14.92	5	99201	50003	110440090
Oropharyngeal pain	28.86	14.92	48	99158	135228	110354865
Tracheobronchitis	28.85	14.92	22	99184	2694	110487399
Mucosal disorder	28.78	14.92	27	99179	4390	110485703
Pulmonary mucormycosis	28.77	14.92	20	99186	2123	110487970
Therapy interrupted	28.75	14.92	5	99201	49817	110440276
Angina pectoris	28.69	14.92	10	99196	62285	110427808
Relapsing fever	28.65	14.92	12	99194	456	110489637
Cholangitis	28.52	14.92	52	99154	16283	110473810
Immunosuppressant drug level decreased	28.46	14.92	22	99184	2749	110487344
Overgrowth fungal	28.34	14.92	9	99197	152	110489941
Renal injury	28.26	14.92	56	99150	18657	110471436
Microangiopathic haemolytic anaemia	28.13	14.92	19	99187	1924	110488169
Jarisch-Herxheimer reaction	28.05	14.92	16	99190	1201	110488892
Head injury	27.93	14.92	3	99203	43014	110447079
Pericoronitis	27.91	14.92	9	99197	160	110489933
Exostosis	27.90	14.92	4	99202	45952	110444141
Influenza like illness	27.86	14.92	23	99183	88389	110401704
Ecthyma	27.61	14.92	15	99191	1024	110489069
Depressed mood	27.59	14.92	10	99196	60799	110429294
Hepatocellular injury	27.58	14.92	104	99102	50538	110439555
Aspergillus test positive	27.46	14.92	15	99191	1035	110489058
Clostridial sepsis	27.32	14.92	15	99191	1046	110489047
Mechanical ventilation	27.07	14.92	23	99183	3284	110486809
Lower respiratory tract infection bacterial	27.00	14.92	15	99191	1070	110489023
Portal fibrosis	26.93	14.92	13	99193	692	110489401
Chronic obstructive pulmonary disease	26.93	14.92	35	99171	109123	110380970
Serum sickness	26.93	14.92	26	99180	4380	110485713
Bronchopleural fistula	26.85	14.92	14	99192	879	110489214
Respiratory gas exchange disorder	26.78	14.92	14	99192	884	110489209
Meningitis	26.74	14.92	42	99164	11660	110478433
Coagulation test abnormal	26.60	14.92	17	99189	1569	110488524
Heart rate increased	26.31	14.92	56	99150	143778	110346315
Petechiae	26.29	14.92	62	99144	23255	110466838
Cytomegalovirus test positive	26.26	14.92	32	99174	7004	110483089
Graft versus host disease in liver	26.26	14.92	20	99186	2445	110487648
Liver function test abnormal	26.24	14.92	127	99079	68823	110421270
Intra-abdominal haemorrhage	26.22	14.92	28	99178	5314	110484779
Prescribed overdose	26.12	14.92	24	99182	87557	110402536
Enterobacter infection	25.99	14.92	29	99177	5782	110484311
Lung abscess	25.90	14.92	27	99179	4985	110485108
Ascites	25.87	14.92	157	99049	92651	110397442
Vanishing bile duct syndrome	25.87	14.92	22	99184	3146	110486947
Hyperpyrexia	25.84	14.92	34	99172	8035	110482058
Cryptococcosis	25.84	14.92	26	99180	4605	110485488
Metabolic disorder	25.81	14.92	39	99167	10471	110479622
Hyperammonaemia	25.62	14.92	45	99161	13687	110476406
Acidosis	25.50	14.92	60	99146	22471	110467622
Coagulation time prolonged	25.35	14.92	21	99185	2896	110487197
Fungal abscess central nervous system	25.30	14.92	9	99197	218	110489875
Electrocardiogram QT prolonged	25.29	14.92	176	99030	108784	110381309
Ileus paralytic	25.27	14.92	41	99165	11696	110478397
Lung infiltration	25.12	14.92	63	99143	24565	110465528
Cardiac disorder	25.10	14.92	19	99187	76261	110413832
Product use issue	25.08	14.92	170	99036	311525	110178568
Haemolysis	25.08	14.92	48	99158	15591	110474502
Septic embolus	25.06	14.92	19	99187	2307	110487786
Acid base balance abnormal	25.06	14.92	11	99195	470	110489623
Antibiotic level above therapeutic	24.94	14.92	14	99192	1019	110489074
Penicillium infection	24.86	14.92	12	99194	639	110489454
Underdose	24.80	14.92	13	99193	63541	110426552
Pyroglutamic acidosis	24.76	14.92	18	99188	2050	110488043
Diabetic macroangiopathy	24.71	14.92	8	99198	144	110489949
Cytopenia	24.63	14.92	71	99135	30045	110460048
Differentiation syndrome	24.57	14.92	21	99185	3023	110487070
Haemorrhage intracranial	24.38	14.92	69	99137	28900	110461193
Death	24.34	14.92	461	98745	698408	109791685
Gingivitis ulcerative	24.23	14.92	11	99195	509	110489584
Bicytopenia	24.16	14.92	30	99176	6694	110483399
Surgery	24.14	14.92	4	99202	41279	110448814
Complications of transplanted lung	24.08	14.92	12	99194	685	110489408
Central nervous system injury	24.07	14.92	8	99198	157	110489936
Hypercapnia	24.05	14.92	39	99167	11120	110478973
Altered state of consciousness	24.03	14.92	109	99097	57517	110432576
SJS-TEN overlap	24.02	14.92	17	99189	1857	110488236
Disseminated aspergillosis	23.98	14.92	19	99187	2461	110487632
Product deposit	23.95	14.92	12	99194	693	110489400
Atelectasis	23.95	14.92	80	99126	36632	110453461
Bacillus infection	23.89	14.92	16	99190	1598	110488495
Cryptococcal meningoencephalitis	23.88	14.92	10	99196	380	110489713
Epidermolysis bullosa	23.85	14.92	10	99196	381	110489712
Pulmonary cavitation	23.81	14.92	18	99188	2176	110487917
Ear pain	23.74	14.92	9	99197	53217	110436876
Pneumonia aspiration	23.66	14.92	139	99067	81094	110408999
Infection in an immunocompromised host	23.59	14.92	17	99189	1910	110488183
Aplasia	23.42	14.92	32	99174	7841	110482252
Pseudomonal bacteraemia	23.40	14.92	24	99182	4347	110485746
Osteomyelitis bacterial	23.21	14.92	11	99195	562	110489531
Drug dependence	23.08	14.92	8	99198	50012	110440081
Paraspinal abscess	23.03	14.92	10	99196	416	110489677
Endotracheal intubation	23.02	14.92	28	99178	6116	110483977
Pulmonary nocardiosis	23.00	14.92	19	99187	2610	110487483
Polyneuropathy	22.91	14.92	72	99134	31940	110458153
Laryngitis	22.90	14.92	5	99201	42406	110447687
Tachycardia	22.88	14.92	307	98899	226338	110263755
Muscle abscess	22.80	14.92	15	99191	1454	110488639
Cognitive disorder	22.70	14.92	27	99179	87484	110402609
Conductive deafness	22.63	14.92	9	99197	299	110489794
Viral haemorrhagic cystitis	22.57	14.92	21	99185	3378	110486715
Disease complication	22.56	14.92	27	99179	5800	110484293
Pulmonary necrosis	22.42	14.92	11	99195	607	110489486
Pneumomediastinum	22.29	14.92	25	99181	5011	110485082
Rectal perforation	22.22	14.92	13	99193	1024	110489069
Ischaemic hepatitis	22.18	14.92	24	99182	4624	110485469
Epilepsy	22.17	14.92	160	99046	100049	110390044
Tissue infiltration	22.15	14.92	13	99193	1030	110489063
Ureaplasma infection	22.10	14.92	15	99191	1531	110488562
Necrosis	22.10	14.92	38	99168	11368	110478725
ADAMTS13 activity decreased	22.05	14.92	9	99197	320	110489773
Heparin-induced thrombocytopenia	22.05	14.92	38	99168	11386	110478707
Interleukin-2 receptor increased	21.97	14.92	9	99197	323	110489770
Cholestatic liver injury	21.97	14.92	30	99176	7346	110482747
Onychomycosis	21.94	14.92	4	99202	38527	110451566
Hyperchloraemia	21.90	14.92	14	99192	1292	110488801
Intervertebral discitis	21.69	14.92	29	99177	6961	110483132
Visual impairment	21.66	14.92	56	99150	134372	110355721
Acute graft versus host disease in intestine	21.62	14.92	26	99180	5613	110484480
Acinetobacter bacteraemia	21.62	14.92	9	99197	337	110489756
Granulocyte count decreased	21.60	14.92	22	99184	3952	110486141
Chest X-ray abnormal	21.56	14.92	32	99174	8455	110481638
Clostridium bacteraemia	21.53	14.92	10	99196	488	110489605
Rhabdomyolysis	21.53	14.92	183	99023	120218	110369875
Hyperkalaemia	21.51	14.92	201	99005	135595	110354498
Trichoglossia	21.45	14.92	12	99194	868	110489225
Extravasation blood	21.25	14.92	10	99196	503	110489590
Resuscitation	21.20	14.92	19	99187	2914	110487179
Upper gastrointestinal haemorrhage	21.07	14.92	95	99111	50001	110440092
Cytomegalovirus enterocolitis	21.04	14.92	17	99189	2264	110487829
Cholangiolitis	20.99	14.92	5	99201	26	110490067
Vulvovaginitis	20.96	14.92	9	99197	364	110489729
Vitamin K deficiency	20.94	14.92	12	99194	909	110489184
Tonsillitis bacterial	20.91	14.92	8	99198	239	110489854
Anticonvulsant drug level below therapeutic	20.85	14.92	13	99193	1149	110488944
Hypogonadism	20.85	14.92	16	99190	1978	110488115
Neoplasm malignant	20.85	14.92	4	99202	37139	110452954
Encephalitis viral	20.79	14.92	19	99187	2988	110487105
Amylase increased	20.79	14.92	39	99167	12480	110477613
Product prescribing error	20.78	14.92	10	99196	51321	110438772
Venoocclusive disease	20.71	14.92	27	99179	6323	110483770
Hypertransaminasaemia	20.63	14.92	58	99148	24197	110465896
Adjusted calcium decreased	20.61	14.92	8	99198	249	110489844
Nervous system disorder	20.58	14.92	69	99137	31652	110458441
Viral infection	20.55	14.92	11	99195	53128	110436965
Abdominal pain	20.53	14.92	330	98876	512659	109977434
Abdominal distension	20.53	14.92	84	99122	175019	110315074
Mediastinal effusion	20.48	14.92	6	99200	76	110490017
Aggression	20.46	14.92	14	99192	59196	110430897
Sopor	20.37	14.92	4	99202	36542	110453551
Necrotising colitis	20.31	14.92	15	99191	1750	110488343
Potentiating drug interaction	20.25	14.92	37	99169	11606	110478487
Wound dehiscence	20.20	14.92	30	99176	7932	110482161
Metabolic alkalosis	20.16	14.92	25	99181	5570	110484523
Acne	20.16	14.92	3	99203	33517	110456576
Electrolyte imbalance	20.13	14.92	76	99130	36952	110453141
Acanthosis	20.05	14.92	10	99196	572	110489521
Splenic injury	20.02	14.92	8	99198	269	110489824
Renal graft infection	20.02	14.92	11	99195	768	110489325
Orthostatic hypotension	19.94	14.92	18	99188	66231	110423862
White blood cell count increased	19.93	14.92	152	99054	96690	110393403
Cardiac failure acute	19.92	14.92	57	99149	24021	110466072
Swollen tongue	19.90	14.92	15	99191	60347	110429746
Therapeutic response decreased	19.89	14.92	35	99171	96464	110393629
Escherichia bacteraemia	19.87	14.92	34	99172	10130	110479963
Myoclonus	19.86	14.92	70	99136	32928	110457165
Neutrophilic dermatosis	19.85	14.92	11	99195	781	110489312
Sleep disorder due to a general medical condition	19.84	14.92	11	99195	52101	110437992
Lymphadenectomy	19.84	14.92	14	99192	1522	110488571
Hot flush	19.81	14.92	18	99188	66018	110424075
Guillain-Barre syndrome	19.78	14.92	35	99171	10709	110479384
Pulmonary sepsis	19.69	14.92	24	99182	5254	110484839
Stenotrophomonas bacteraemia	19.67	14.92	8	99198	282	110489811
Blood albumin decreased	19.61	14.92	62	99144	27590	110462503
Generalised tonic-clonic seizure	19.59	14.92	99	99107	54581	110435512
X-ray abnormal	19.59	14.92	5	99201	38112	110451981
Acute lymphocytic leukaemia	19.57	14.92	25	99181	5740	110484353
Sinus disorder	19.52	14.92	3	99203	32725	110457368
Diverticulitis	19.38	14.92	12	99194	53510	110436583
Sepsis syndrome	19.36	14.92	14	99192	1582	110488511
Vertigo	19.30	14.92	30	99176	86840	110403253
Cholangitis infective	19.26	14.92	11	99195	828	110489265
Limb injury	19.22	14.92	5	99201	37631	110452462
Malnutrition	19.19	14.92	61	99145	27218	110462875
Noninfectious peritonitis	19.13	14.92	8	99198	303	110489790
BK polyomavirus test positive	19.10	14.92	8	99198	304	110489789
Enterocolitis haemorrhagic	19.08	14.92	17	99189	2587	110487506
Eczema	19.08	14.92	22	99184	72271	110417822
Gastroenteritis staphylococcal	18.93	14.92	8	99198	311	110489782
Drug level below therapeutic	18.93	14.92	36	99170	11637	110478456
Abscess neck	18.91	14.92	13	99193	1355	110488738
Vascular pseudoaneurysm	18.89	14.92	21	99185	4169	110485924
Chimerism	18.88	14.92	8	99198	313	110489780
Bifidobacterium infection	18.80	14.92	6	99200	103	110489990
Neuralgia	18.80	14.92	10	99196	48468	110441625
Nephrolithiasis	18.75	14.92	19	99187	66193	110423900
Ocular hyperaemia	18.62	14.92	6	99200	39280	110450813
Haemothorax	18.57	14.92	27	99179	7004	110483089
Joint dislocation	18.53	14.92	4	99202	34186	110455907
Large intestine perforation	18.52	14.92	44	99162	16585	110473508
Chorioretinitis	18.51	14.92	13	99193	1402	110488691
Hepatic infection fungal	18.46	14.92	8	99198	331	110489762
Endocarditis candida	18.38	14.92	6	99200	111	110489982
Splenomegaly	18.36	14.92	56	99150	24442	110465651
Nightmare	18.31	14.92	6	99200	38857	110451236
Pulseless electrical activity	18.29	14.92	44	99162	16713	110473380
Bronchial anastomosis complication	18.23	14.92	6	99200	114	110489979
Hyperthermia	18.22	14.92	51	99155	21221	110468872
Skin maceration	18.21	14.92	7	99199	212	110489881
Skin laceration	18.19	14.92	4	99202	33749	110456344
Arterial angioplasty	18.14	14.92	5	99201	50	110490043
Hypoglossal nerve paresis	18.13	14.92	6	99200	116	110489977
Lacrimation increased	18.09	14.92	3	99203	30947	110459146
Respiratory acidosis	18.09	14.92	39	99167	13787	110476306
HIV viraemia	18.04	14.92	6	99200	118	110489975
Extravasation	18.03	14.92	22	99184	4823	110485270
Cerebral infarction	17.97	14.92	93	99113	51745	110438348
Cytokine storm	17.91	14.92	13	99193	1477	110488616
Disseminated trichosporonosis	17.85	14.92	7	99199	224	110489869
Rash erythematous	17.72	14.92	130	99076	81702	110408391
Tracheal injury	17.67	14.92	7	99199	230	110489863
Transformation to acute myeloid leukaemia	17.66	14.92	13	99193	1510	110488583
Face oedema	17.62	14.92	68	99138	33401	110456692
Colonic fistula	17.61	14.92	10	99196	744	110489349
Sedation	17.54	14.92	22	99184	69661	110420432
Haemostasis	17.54	14.92	9	99197	547	110489546
Metastases to liver	17.51	14.92	5	99201	35381	110454712
Angioedema	17.48	14.92	39	99167	98461	110391632
Refractoriness to platelet transfusion	17.37	14.92	7	99199	241	110489852
Pneumonia cytomegaloviral	17.35	14.92	26	99180	6928	110483165
Klebsiella sepsis	17.34	14.92	20	99186	4133	110485960
Pneumonia acinetobacter	17.33	14.92	8	99198	385	110489708
Gastrointestinal fungal infection	17.31	14.92	10	99196	769	110489324
Pollakiuria	17.31	14.92	9	99197	44186	110445907
Acute graft versus host disease in skin	17.27	14.92	33	99173	10707	110479386
Bladder irrigation	17.24	14.92	5	99201	61	110490032
Urinary tract inflammation	17.23	14.92	8	99198	390	110489703
Subcutaneous emphysema	17.23	14.92	16	99190	2568	110487525
Serum sickness-like reaction	17.20	14.92	10	99196	778	110489315
Intestinal pseudo-obstruction	17.20	14.92	18	99188	3338	110486755
Herpes simplex hepatitis	17.19	14.92	10	99196	779	110489314
Hyperaemia	17.17	14.92	19	99187	3754	110486339
Diabetes mellitus inadequate control	17.15	14.92	3	99203	29772	110460321
Flatulence	17.14	14.92	13	99193	52136	110437957
Dysphonia	17.08	14.92	26	99180	75903	110414190
Candida pneumonia	17.05	14.92	11	99195	1032	110489061
Convulsive threshold lowered	17.02	14.92	11	99195	1035	110489058
Septal panniculitis	16.96	14.92	6	99200	143	110489950
Respiratory tract infection fungal	16.94	14.92	12	99194	1312	110488781
H1N1 influenza	16.94	14.92	17	99189	3001	110487092
Delayed graft function	16.94	14.92	20	99186	4237	110485856
Alveolitis necrotising	16.92	14.92	4	99202	20	110490073
Body temperature decreased	16.88	14.92	6	99200	36929	110453164
Hepatic haemorrhage	16.86	14.92	12	99194	1322	110488771
Retroperitoneal haematoma	16.86	14.92	24	99182	6107	110483986
Blast cell count increased	16.82	14.92	13	99193	1624	110488469
Disseminated sporotrichosis	16.81	14.92	5	99201	67	110490026
Lymphopenia	16.76	14.92	76	99130	40094	110449999
Cystitis haemorrhagic	16.62	14.92	35	99171	12174	110477919
Dementia	16.57	14.92	4	99202	31669	110458424
Ulcer	16.56	14.92	9	99197	43107	110446986
Corynebacterium infection	16.56	14.92	14	99192	1986	110488107
Oesophagitis	16.50	14.92	60	99146	28655	110461438
Acute graft versus host disease	16.47	14.92	36	99170	12845	110477248
Eye disorder	16.46	14.92	3	99203	28903	110461190
Hypereosinophilic syndrome	16.46	14.92	10	99196	844	110489249
Low cardiac output syndrome	16.46	14.92	11	99195	1095	110488998
Extrapyramidal disorder	16.43	14.92	3	99203	28864	110461229
Febrile convulsion	16.42	14.92	11	99195	1099	110488994
Musculoskeletal chest pain	16.42	14.92	3	99203	28844	110461249
Pneumocystis jirovecii infection	16.40	14.92	20	99186	4380	110485713
Incorrect route of product administration	16.37	14.92	20	99186	64041	110426052
Psychotic disorder	16.36	14.92	13	99193	50924	110439169
Intestinal haemorrhage	16.29	14.92	26	99180	7315	110482778
Superinfection bacterial	16.27	14.92	15	99191	2386	110487707
Gastroenteritis viral	16.23	14.92	4	99202	31222	110458871
Organising pneumonia	16.20	14.92	38	99168	14205	110475888
Hypoperfusion	16.19	14.92	17	99189	3164	110486929
Neurological decompensation	16.14	14.92	25	99181	6858	110483235
Epstein-Barr virus infection	16.13	14.92	45	99161	18693	110471400
Renal tubular necrosis	16.11	14.92	62	99144	30413	110459680
Idiopathic pneumonia syndrome	16.11	14.92	10	99196	877	110489216
Hepatitis acute	16.08	14.92	45	99161	18721	110471372
Throat tightness	16.08	14.92	5	99201	33484	110456609
Listeriosis	16.07	14.92	16	99190	2798	110487295
Gallbladder fistula	16.03	14.92	4	99202	26	110490067
Hepatosplenic candidiasis	16.01	14.92	9	99197	657	110489436
Pulmonary alveolar haemorrhage	15.99	14.92	47	99159	20103	110469990
Herpes simplex viraemia	15.97	14.92	9	99197	660	110489433
Infection reactivation	15.95	14.92	19	99187	4062	110486031
Tracheal ulcer	15.90	14.92	4	99202	27	110490066
Obstructive airways disorder	15.82	14.92	11	99195	46138	110443955
Hypersomnia	15.79	14.92	3	99203	28058	110462035
Diplopia	15.72	14.92	9	99197	41885	110448208
Acoustic neuroma	15.69	14.92	7	99199	311	110489782
Gastrointestinal oedema	15.68	14.92	17	99189	3281	110486812
Obliterative bronchiolitis	15.66	14.92	18	99188	3705	110486388
Soft tissue necrosis	15.66	14.92	11	99195	1187	110488906
Hypovolaemic shock	15.61	14.92	38	99168	14545	110475548
Radiation fibrosis - lung	15.60	14.92	5	99201	87	110490006
Psoas abscess	15.59	14.92	12	99194	1490	110488603
Hyperchlorhydria	15.57	14.92	14	99192	2155	110487938
Embolic cerebral infarction	15.56	14.92	12	99194	1494	110488599
Thrombocytosis	15.47	14.92	31	99175	10413	110479680
Faeces pale	15.44	14.92	17	99189	3340	110486753
Device related bacteraemia	15.40	14.92	11	99195	1219	110488874
Abdominal wound dehiscence	15.24	14.92	7	99199	333	110489760
Puncture site haemorrhage	15.22	14.92	9	99197	723	110489370
Blood creatine phosphokinase increased	15.20	14.92	115	99091	72962	110417131
Respiratory alkalosis	15.16	14.92	22	99184	5699	110484394
Device issue	15.13	14.92	6	99200	34529	110455564
Meningitis enterococcal	15.12	14.92	6	99200	198	110489895
Gastrointestinal mucormycosis	15.12	14.92	9	99197	732	110489361
Delivery	15	14.92	10	99196	991	110489102
Gout	14.99	14.92	7	99199	36559	110453534
Blood culture positive	14.95	14.92	28	99178	8948	110481145
Dehiscence	14.93	14.92	9	99197	749	110489344

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	94.88	40.66	51	190	1582	112130

Pharmacologic Action:

Source	Code	Description
ATC	J01DH02	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Carbapenems
ATC	J01DH52	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Carbapenems
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000900	Anti-Bacterial Agents
CHEBI has role	CHEBI:36047	antibacterial drug
CHEBI has role	CHEBI:33231	antitubercular agent
CHEBI has role	CHEBI:33281	antimicrobial agent
CHEBI has role	CHEBI:33282	antibacterial agent
CHEBI has role	CHEBI:35441	antiinfective agent
CHEBI has role	CHEBI:35610	antineoplastic agent
CHEBI has role	CHEBI:88188	drug allergen

Related Drugs by ATC class:

J01DH Carbapenems 10 drugs

betamipron biapenem cilastatin doripenem ertapenem imipenem panipenem relebactam tebipenem pivoxil vaborbactam

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Streptococcal meningitis	indication	4510004	DOID:11574
Infection due to Pseudomonas aeruginosa	indication	11218009
Peritonitis	indication	48661000
Pneumococcal meningitis	indication	51169003
Abdominal abscess	indication	75100008
Bacterial meningitis	indication	95883001	DOID:9470
Infectious disease of abdomen	indication	128070006
Neisseria meningitidis meningitis	indication	192644005
Complicated appendicitis	indication	418171008
Peptostreptococcus Complicated Appendicitis	indication
Pseudomonas Aeruginosa Complicated Appendicitis	indication
E. Coli Complicated Appendicitis	indication
Streptococcal Peritonitis	indication
Bacteroides Peritonitis	indication
Streptococcus Complicated Appendicitis	indication
Klebsiella Pneumoniae Peritonitis	indication
Bacteroides Complicated Appendicitis	indication
Complicated Skin and Skin Structure Infection	indication
E. Coli Peritonitis	indication
H. Influenzae Meningitis	indication
Peptostreptococcus Peritonitis	indication
Klebsiella Complicated Appendicitis	indication
Pyrexia of unknown origin	off-label use	7520000
Bacterial septicemia	off-label use	10001005	DOID:0040085
Inhalational anthrax	off-label use	11389007
Nocardiosis	off-label use	29227009	DOID:2312
Bacterial pneumonia	off-label use	53084003	DOID:874
Cholangitis	off-label use	82403002	DOID:9446
Gastrointestinal anthrax	off-label use	111798006	DOID:13386
Infection by Campylobacter fetus	off-label use	111835002
Sepsis of the newborn	off-label use	206376005
Sepsis syndrome	off-label use	238150007
Diverticulitis of gastrointestinal tract	off-label use	271366000
Neonatal meningitis	off-label use	276674008
Anthrax	off-label use	409498004	DOID:7427
Nosocomial pneumonia	off-label use	425464007
Melioidosis	off-label use	428111003	DOID:5052
Pneumonia due to Gram negative bacteria	off-label use	430395005
Complicated Urinary Tract Infections	off-label use
Diabetic Foot Infection	off-label use
Clostridium Perfringens Empyema	off-label use
Pseudomonas Respiratory Tract Infection in Cystic Fibrosis	off-label use
Kidney disease	contraindication	90708001	DOID:557
Seizure disorder	contraindication	128613002
Lesion of brain	contraindication	301766008
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Pseudomembranous enterocolitis	contraindication	397683000

🐶 Veterinary Drug Use

None

🐶 Veterinary products