Stem definition | Drug id | CAS RN |
---|---|---|
analogues of penicillanic acid antibiotics modified in the five-membered ring | 1709 | 96036-03-2 |
Dose | Unit | Route |
---|---|---|
3 | g | P |
3 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 4 | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 70 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 111.76 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 0 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.30 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 3.90 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.87 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
June 21, 1996 | FDA | ASTRAZENECA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Multiple organ dysfunction syndrome | 542.38 | 17.48 | 347 | 29048 | 49990 | 50525739 |
Septic shock | 453.26 | 17.48 | 326 | 29069 | 56849 | 50518880 |
Drug reaction with eosinophilia and systemic symptoms | 333.57 | 17.48 | 207 | 29188 | 28217 | 50547512 |
Drug resistance | 325.77 | 17.48 | 177 | 29218 | 18812 | 50556917 |
Pathogen resistance | 303.85 | 17.48 | 117 | 29278 | 5572 | 50570157 |
Sepsis | 248.40 | 17.48 | 344 | 29051 | 132581 | 50443148 |
Respiratory failure | 205.78 | 17.48 | 259 | 29136 | 90922 | 50484807 |
Febrile neutropenia | 205.61 | 17.48 | 268 | 29127 | 97399 | 50478330 |
Thrombocytopenia | 194.30 | 17.48 | 300 | 29095 | 127373 | 50448356 |
Pyrexia | 172.71 | 17.48 | 548 | 28847 | 379655 | 50196074 |
Pain | 172.44 | 17.48 | 61 | 29334 | 578842 | 49996887 |
Bronchopulmonary aspergillosis | 156.36 | 17.48 | 80 | 29315 | 7512 | 50568217 |
Acute kidney injury | 149.74 | 17.48 | 376 | 29019 | 227682 | 50348047 |
Toxic epidermal necrolysis | 148.73 | 17.48 | 112 | 29283 | 20880 | 50554849 |
Fatigue | 148.50 | 17.48 | 117 | 29278 | 707484 | 49868245 |
Systemic candida | 147.61 | 17.48 | 57 | 29338 | 2733 | 50572996 |
Haemophagocytic lymphohistiocytosis | 135.70 | 17.48 | 76 | 29319 | 8557 | 50567172 |
Arthralgia | 134.31 | 17.48 | 44 | 29351 | 438658 | 50137071 |
Pancytopenia | 132.69 | 17.48 | 201 | 29194 | 83829 | 50491900 |
Headache | 126.03 | 17.48 | 69 | 29326 | 506466 | 50069263 |
Off label use | 121.33 | 17.48 | 570 | 28825 | 473856 | 50101873 |
Joint swelling | 117.79 | 17.48 | 6 | 29389 | 245280 | 50330449 |
Clostridium difficile colitis | 111.14 | 17.48 | 88 | 29307 | 17654 | 50558075 |
Neutropenia | 107.66 | 17.48 | 254 | 29141 | 147711 | 50428018 |
Enterococcal infection | 106.44 | 17.48 | 60 | 29335 | 6838 | 50568891 |
Abdominal discomfort | 104.25 | 17.48 | 8 | 29387 | 231633 | 50344096 |
Candida infection | 101.06 | 17.48 | 94 | 29301 | 23429 | 50552300 |
Rheumatoid arthritis | 100.35 | 17.48 | 4 | 29391 | 202546 | 50373183 |
Fall | 99.95 | 17.48 | 35 | 29360 | 334897 | 50240832 |
Candida sepsis | 93.26 | 17.48 | 33 | 29362 | 1234 | 50574495 |
Acinetobacter infection | 93.12 | 17.48 | 34 | 29361 | 1393 | 50574336 |
Drug intolerance | 92.07 | 17.48 | 10 | 29385 | 219094 | 50356635 |
Fungaemia | 88.58 | 17.48 | 36 | 29359 | 1976 | 50573753 |
Aspergillus infection | 85.87 | 17.48 | 52 | 29343 | 6769 | 50568960 |
Shock | 85.78 | 17.48 | 81 | 29314 | 20569 | 50555160 |
Peripheral swelling | 80.23 | 17.48 | 12 | 29383 | 205924 | 50369805 |
Dysbiosis | 79.83 | 17.48 | 25 | 29370 | 635 | 50575094 |
Acute respiratory distress syndrome | 78.69 | 17.48 | 78 | 29317 | 21021 | 50554708 |
Disseminated intravascular coagulation | 78.52 | 17.48 | 71 | 29324 | 17064 | 50558665 |
Nasopharyngitis | 75.71 | 17.48 | 11 | 29384 | 192916 | 50382813 |
Hepatic function abnormal | 75.45 | 17.48 | 94 | 29301 | 32587 | 50543142 |
Stenotrophomonas infection | 73.95 | 17.48 | 30 | 29365 | 1639 | 50574090 |
Product dose omission issue | 73.26 | 17.48 | 10 | 29385 | 183828 | 50391901 |
Swelling | 73.18 | 17.48 | 14 | 29381 | 200858 | 50374871 |
Agranulocytosis | 72.24 | 17.48 | 75 | 29320 | 21346 | 50554383 |
Eosinophilia | 69.64 | 17.48 | 69 | 29326 | 18583 | 50557146 |
Stevens-Johnson syndrome | 65.99 | 17.48 | 72 | 29323 | 21680 | 50554049 |
Mucormycosis | 65.56 | 17.48 | 31 | 29364 | 2452 | 50573277 |
Contraindicated product administered | 64.62 | 17.48 | 6 | 29389 | 148952 | 50426777 |
Acute generalised exanthematous pustulosis | 63.98 | 17.48 | 48 | 29347 | 8890 | 50566839 |
Pseudomonas infection | 63.88 | 17.48 | 49 | 29346 | 9381 | 50566348 |
Pain in extremity | 63.66 | 17.48 | 40 | 29355 | 272825 | 50302904 |
Renal impairment | 62.86 | 17.48 | 137 | 29258 | 75524 | 50500205 |
Renal failure | 62.77 | 17.48 | 169 | 29226 | 106464 | 50469265 |
Rash maculo-papular | 62.09 | 17.48 | 77 | 29318 | 26564 | 50549165 |
Weight increased | 62.06 | 17.48 | 20 | 29375 | 201871 | 50373858 |
Dizziness | 61.94 | 17.48 | 66 | 29329 | 346303 | 50229426 |
Myelosuppression | 61.91 | 17.48 | 56 | 29339 | 13461 | 50562268 |
Geotrichum infection | 61.89 | 17.48 | 19 | 29376 | 451 | 50575278 |
Drug eruption | 61.17 | 17.48 | 72 | 29323 | 23534 | 50552195 |
Pseudomembranous colitis | 59.24 | 17.48 | 30 | 29365 | 2755 | 50572974 |
Therapeutic product effect decreased | 57.65 | 17.48 | 6 | 29389 | 136044 | 50439685 |
Muscle spasms | 57.40 | 17.48 | 4 | 29391 | 125549 | 50450180 |
Lactic acidosis | 57.20 | 17.48 | 83 | 29312 | 33272 | 50542457 |
Cytokine release syndrome | 56.60 | 17.48 | 44 | 29351 | 8590 | 50567139 |
Sinusitis | 55.88 | 17.48 | 15 | 29380 | 170543 | 50405186 |
Klebsiella infection | 54.56 | 17.48 | 40 | 29355 | 7154 | 50568575 |
Systemic lupus erythematosus | 52.92 | 17.48 | 9 | 29386 | 140613 | 50435116 |
Pneumonia fungal | 51.99 | 17.48 | 32 | 29363 | 4288 | 50571441 |
Depression | 51.52 | 17.48 | 16 | 29379 | 165407 | 50410322 |
Acute respiratory failure | 51.37 | 17.48 | 73 | 29322 | 28709 | 50547020 |
Drug level decreased | 51.07 | 17.48 | 37 | 29358 | 6496 | 50569233 |
Cardiac arrest | 50.65 | 17.48 | 134 | 29261 | 83517 | 50492212 |
Linear IgA disease | 50.33 | 17.48 | 21 | 29374 | 1233 | 50574496 |
Coagulopathy | 50.30 | 17.48 | 57 | 29338 | 17887 | 50557842 |
Encephalopathy | 49.45 | 17.48 | 78 | 29317 | 33633 | 50542096 |
Alopecia | 49.25 | 17.48 | 42 | 29353 | 245005 | 50330724 |
Platelet count decreased | 48.93 | 17.48 | 149 | 29246 | 100577 | 50475152 |
Neutropenic sepsis | 48.54 | 17.48 | 50 | 29345 | 14097 | 50561632 |
Peritonitis | 48.26 | 17.48 | 52 | 29343 | 15434 | 50560295 |
Pneumonia | 47.72 | 17.48 | 379 | 29016 | 378022 | 50197707 |
Blood bilirubin increased | 46.81 | 17.48 | 74 | 29321 | 31964 | 50543765 |
Musculoskeletal stiffness | 46.67 | 17.48 | 9 | 29386 | 128472 | 50447257 |
Haemodynamic instability | 46.42 | 17.48 | 38 | 29357 | 7986 | 50567743 |
Fungal infection | 46.27 | 17.48 | 71 | 29324 | 29894 | 50545835 |
Bacteraemia | 45.92 | 17.48 | 49 | 29346 | 14384 | 50561345 |
Acute myeloid leukaemia | 45.90 | 17.48 | 50 | 29345 | 15024 | 50560705 |
Asthenia | 45.47 | 17.48 | 72 | 29323 | 318970 | 50256759 |
Excessive eye blinking | 45.36 | 17.48 | 18 | 29377 | 928 | 50574801 |
Systemic inflammatory response syndrome | 45.05 | 17.48 | 31 | 29364 | 5018 | 50570711 |
Malaise | 44.79 | 17.48 | 79 | 29316 | 335453 | 50240276 |
Anuria | 44.59 | 17.48 | 43 | 29352 | 11201 | 50564528 |
Hyperbilirubinaemia | 44.52 | 17.48 | 40 | 29355 | 9530 | 50566199 |
Acute hepatic failure | 44.29 | 17.48 | 50 | 29345 | 15627 | 50560102 |
Enterocolitis | 44.21 | 17.48 | 34 | 29361 | 6533 | 50569196 |
Gait disturbance | 44.10 | 17.48 | 16 | 29379 | 149989 | 50425740 |
Drug ineffective for unapproved indication | 44.06 | 17.48 | 58 | 29337 | 21223 | 50554506 |
Wound | 43.96 | 17.48 | 5 | 29390 | 105789 | 50469940 |
Rhinocerebral mucormycosis | 43.36 | 17.48 | 12 | 29383 | 195 | 50575534 |
Brain abscess | 43.15 | 17.48 | 21 | 29374 | 1770 | 50573959 |
Blood lactate dehydrogenase increased | 43.13 | 17.48 | 55 | 29340 | 19507 | 50556222 |
Insomnia | 43.05 | 17.48 | 24 | 29371 | 174841 | 50400888 |
Neutropenic colitis | 42.72 | 17.48 | 23 | 29372 | 2394 | 50573335 |
Weight decreased | 41.96 | 17.48 | 40 | 29355 | 221205 | 50354524 |
Anaemia | 41.72 | 17.48 | 270 | 29125 | 252186 | 50323543 |
Procalcitonin increased | 41.69 | 17.48 | 16 | 29379 | 754 | 50574975 |
Graft versus host disease | 41.67 | 17.48 | 32 | 29363 | 6134 | 50569595 |
Neurotoxicity | 41.62 | 17.48 | 47 | 29348 | 14693 | 50561036 |
Oliguria | 41.53 | 17.48 | 36 | 29359 | 8180 | 50567549 |
Meningitis candida | 41.17 | 17.48 | 9 | 29386 | 50 | 50575679 |
Multiple-drug resistance | 41.03 | 17.48 | 25 | 29370 | 3289 | 50572440 |
Pleural effusion | 40.97 | 17.48 | 122 | 29273 | 81332 | 50494397 |
Enterococcal sepsis | 40.18 | 17.48 | 18 | 29377 | 1257 | 50574472 |
Hyperlactacidaemia | 39.81 | 17.48 | 22 | 29373 | 2411 | 50573318 |
Eosinophilic pneumonia acute | 38.57 | 17.48 | 12 | 29383 | 298 | 50575431 |
Anticonvulsant drug level decreased | 38.40 | 17.48 | 17 | 29378 | 1154 | 50574575 |
Mucosal inflammation | 38.35 | 17.48 | 77 | 29318 | 40065 | 50535664 |
Drug interaction | 37.68 | 17.48 | 221 | 29174 | 199400 | 50376329 |
Guillain-Barre syndrome | 37.43 | 17.48 | 24 | 29371 | 3453 | 50572276 |
Pneumonia bacterial | 36.89 | 17.48 | 32 | 29363 | 7277 | 50568452 |
Trichosporon infection | 36.75 | 17.48 | 11 | 29384 | 239 | 50575490 |
Weissella infection | 36.55 | 17.48 | 7 | 29388 | 17 | 50575712 |
Discomfort | 36.50 | 17.48 | 9 | 29386 | 108371 | 50467358 |
Perinephric abscess | 36.22 | 17.48 | 10 | 29385 | 161 | 50575568 |
Hyperchloraemia | 35.94 | 17.48 | 14 | 29381 | 687 | 50575042 |
Factor V inhibition | 35.94 | 17.48 | 10 | 29385 | 166 | 50575563 |
Toxic encephalopathy | 35.92 | 17.48 | 28 | 29367 | 5487 | 50570242 |
Leukopenia | 35.73 | 17.48 | 103 | 29292 | 67425 | 50508304 |
Fungal sepsis | 35.44 | 17.48 | 16 | 29379 | 1138 | 50574591 |
Asthma | 35.23 | 17.48 | 5 | 29390 | 89332 | 50486397 |
Mixed liver injury | 35.13 | 17.48 | 23 | 29372 | 3428 | 50572301 |
C-reactive protein increased | 34.79 | 17.48 | 101 | 29294 | 66373 | 50509356 |
Hepatic failure | 34.59 | 17.48 | 65 | 29330 | 32218 | 50543511 |
Pericarditis | 34.57 | 17.48 | 3 | 29392 | 78686 | 50497043 |
Hepatic infarction | 34.48 | 17.48 | 13 | 29382 | 583 | 50575146 |
Bone marrow failure | 33.90 | 17.48 | 59 | 29336 | 27565 | 50548164 |
Anxiety | 33.79 | 17.48 | 32 | 29363 | 177574 | 50398155 |
Product use in unapproved indication | 33.73 | 17.48 | 145 | 29250 | 115674 | 50460055 |
Transaminases increased | 33.59 | 17.48 | 59 | 29336 | 27765 | 50547964 |
Umbilical erythema | 33.24 | 17.48 | 8 | 29387 | 72 | 50575657 |
Metabolic acidosis | 33.02 | 17.48 | 71 | 29324 | 38754 | 50536975 |
Contusion | 32.91 | 17.48 | 12 | 29383 | 112171 | 50463558 |
Feeling abnormal | 32.69 | 17.48 | 16 | 29379 | 125476 | 50450253 |
Injection site erythema | 32.53 | 17.48 | 3 | 29392 | 74933 | 50500796 |
Clostridium difficile infection | 32.09 | 17.48 | 55 | 29340 | 25384 | 50550345 |
Blood pressure increased | 31.72 | 17.48 | 19 | 29376 | 133113 | 50442616 |
Arthritis | 31.64 | 17.48 | 6 | 29389 | 86715 | 50489014 |
Alanine aminotransferase increased | 31.64 | 17.48 | 118 | 29277 | 88241 | 50487488 |
Product deposit | 31.45 | 17.48 | 9 | 29386 | 166 | 50575563 |
Nausea | 31.41 | 17.48 | 261 | 29134 | 705137 | 49870592 |
Emphysematous pyelonephritis | 31.30 | 17.48 | 9 | 29386 | 169 | 50575560 |
Escherichia infection | 31.08 | 17.48 | 35 | 29360 | 10906 | 50564823 |
Disease progression | 31.04 | 17.48 | 124 | 29271 | 95742 | 50479987 |
Cholestasis | 30.84 | 17.48 | 54 | 29341 | 25347 | 50550382 |
Abscess neck | 30.70 | 17.48 | 12 | 29383 | 594 | 50575135 |
Nephropathy toxic | 30.52 | 17.48 | 30 | 29365 | 7999 | 50567730 |
Pyelonephritis fungal | 30.49 | 17.48 | 8 | 29387 | 105 | 50575624 |
Hypotension | 30.23 | 17.48 | 237 | 29158 | 235232 | 50340497 |
Seizure | 30.14 | 17.48 | 142 | 29253 | 117732 | 50457997 |
Renal abscess | 29.92 | 17.48 | 12 | 29383 | 636 | 50575093 |
Infusion related reaction | 29.48 | 17.48 | 33 | 29362 | 169524 | 50406205 |
Diabetic macroangiopathy | 29.26 | 17.48 | 8 | 29387 | 124 | 50575605 |
Brain oedema | 29.21 | 17.48 | 36 | 29359 | 12334 | 50563395 |
Haemorrhage intracranial | 29.20 | 17.48 | 36 | 29359 | 12338 | 50563391 |
Adjusted calcium decreased | 29.14 | 17.48 | 8 | 29387 | 126 | 50575603 |
Hypoxia | 29.02 | 17.48 | 80 | 29315 | 51043 | 50524686 |
Blood alkaline phosphatase increased | 28.95 | 17.48 | 66 | 29329 | 37460 | 50538269 |
Noninfectious peritonitis | 28.68 | 17.48 | 8 | 29387 | 134 | 50575595 |
Pneumothorax | 28.66 | 17.48 | 38 | 29357 | 13996 | 50561733 |
Aspartate aminotransferase increased | 28.62 | 17.48 | 105 | 29290 | 77893 | 50497836 |
Central nervous system injury | 28.57 | 17.48 | 8 | 29387 | 136 | 50575593 |
Haemostasis | 28.39 | 17.48 | 9 | 29386 | 238 | 50575491 |
Posterior reversible encephalopathy syndrome | 28.33 | 17.48 | 39 | 29356 | 14889 | 50560840 |
Cytopenia | 28.28 | 17.48 | 30 | 29365 | 8745 | 50566984 |
Staphylococcal infection | 27.87 | 17.48 | 63 | 29332 | 35553 | 50540176 |
Toxic skin eruption | 26.98 | 17.48 | 33 | 29362 | 11218 | 50564511 |
Hypernatraemia | 26.64 | 17.48 | 25 | 29370 | 6296 | 50569433 |
Respiratory distress | 26.20 | 17.48 | 56 | 29339 | 30433 | 50545296 |
Gamma-glutamyltransferase increased | 26.14 | 17.48 | 55 | 29340 | 29568 | 50546161 |
Splenic injury | 26.09 | 17.48 | 8 | 29387 | 189 | 50575540 |
Drug hypersensitivity | 26.04 | 17.48 | 68 | 29327 | 250942 | 50324787 |
Migraine | 25.84 | 17.48 | 6 | 29389 | 75274 | 50500455 |
Liver abscess | 25.71 | 17.48 | 17 | 29378 | 2576 | 50573153 |
Abdominal pain upper | 25.57 | 17.48 | 33 | 29362 | 159276 | 50416453 |
Hyperchlorhydria | 25.51 | 17.48 | 14 | 29381 | 1514 | 50574215 |
Hypoalbuminaemia | 25.42 | 17.48 | 30 | 29365 | 9830 | 50565899 |
Globulins decreased | 25.22 | 17.48 | 8 | 29387 | 212 | 50575517 |
Mycobacterium abscessus infection | 25.10 | 17.48 | 10 | 29385 | 521 | 50575208 |
Hypersensitivity | 24.92 | 17.48 | 55 | 29340 | 215106 | 50360623 |
Tubulointerstitial nephritis | 24.84 | 17.48 | 37 | 29358 | 15174 | 50560555 |
Death neonatal | 24.81 | 17.48 | 8 | 29387 | 224 | 50575505 |
Hypotonia | 24.80 | 17.48 | 27 | 29368 | 8107 | 50567622 |
Cross sensitivity reaction | 24.75 | 17.48 | 15 | 29380 | 1954 | 50573775 |
Haemorrhagic disorder | 24.72 | 17.48 | 11 | 29384 | 756 | 50574973 |
Hyperoxaluria | 24.68 | 17.48 | 7 | 29388 | 125 | 50575604 |
Acid base balance abnormal | 24.31 | 17.48 | 8 | 29387 | 239 | 50575490 |
Rash morbilliform | 24.28 | 17.48 | 17 | 29378 | 2829 | 50572900 |
Morganella infection | 24.16 | 17.48 | 10 | 29385 | 575 | 50575154 |
Cerebral mass effect | 23.99 | 17.48 | 11 | 29384 | 811 | 50574918 |
Type IV hypersensitivity reaction | 23.95 | 17.48 | 16 | 29379 | 2466 | 50573263 |
Drug ineffective | 23.89 | 17.48 | 633 | 28762 | 818700 | 49757029 |
Myocardial infarction | 23.72 | 17.48 | 11 | 29384 | 89016 | 50486713 |
Herpes simplex viraemia | 23.70 | 17.48 | 7 | 29388 | 145 | 50575584 |
Hyperkalaemia | 23.20 | 17.48 | 71 | 29324 | 48018 | 50527711 |
Neutrophil count decreased | 23.19 | 17.48 | 69 | 29326 | 45957 | 50529772 |
Relapsing fever | 23.13 | 17.48 | 7 | 29388 | 158 | 50575571 |
Escherichia bacteraemia | 22.89 | 17.48 | 17 | 29378 | 3099 | 50572630 |
Dermatitis exfoliative generalised | 22.84 | 17.48 | 17 | 29378 | 3109 | 50572620 |
Nosocomial infection | 22.83 | 17.48 | 13 | 29382 | 1509 | 50574220 |
Hypertransaminasaemia | 22.80 | 17.48 | 18 | 29377 | 3593 | 50572136 |
Venoocclusive disease | 22.70 | 17.48 | 14 | 29381 | 1882 | 50573847 |
Delayed graft function | 22.69 | 17.48 | 11 | 29384 | 919 | 50574810 |
Epilepsy | 22.57 | 17.48 | 43 | 29352 | 21524 | 50554205 |
Colitis | 22.57 | 17.48 | 61 | 29334 | 38468 | 50537261 |
Metabolic alkalosis | 22.57 | 17.48 | 16 | 29379 | 2715 | 50573014 |
Cytomegalovirus viraemia | 22.53 | 17.48 | 20 | 29375 | 4689 | 50571040 |
Aplastic anaemia | 22.49 | 17.48 | 25 | 29370 | 7678 | 50568051 |
Dry mouth | 22.49 | 17.48 | 3 | 29392 | 56175 | 50519554 |
Status epilepticus | 22.45 | 17.48 | 33 | 29362 | 13373 | 50562356 |
Vulvovaginitis | 22.41 | 17.48 | 8 | 29387 | 307 | 50575422 |
Hyperhidrosis | 22.39 | 17.48 | 12 | 29383 | 89414 | 50486315 |
Pulmonary haemorrhage | 22.37 | 17.48 | 23 | 29372 | 6469 | 50569260 |
Lung abscess | 22.33 | 17.48 | 13 | 29382 | 1573 | 50574156 |
Folate deficiency | 22.31 | 17.48 | 14 | 29381 | 1941 | 50573788 |
Overgrowth fungal | 22.13 | 17.48 | 6 | 29389 | 90 | 50575639 |
Hypochromasia | 22.04 | 17.48 | 8 | 29387 | 322 | 50575407 |
Somnolence | 22.01 | 17.48 | 35 | 29360 | 154950 | 50420779 |
Herpes simplex hepatitis | 21.97 | 17.48 | 8 | 29387 | 325 | 50575404 |
Osteomyelitis bacterial | 21.91 | 17.48 | 7 | 29388 | 190 | 50575539 |
Hyperaemia | 21.70 | 17.48 | 14 | 29381 | 2036 | 50573693 |
Diffuse large B-cell lymphoma refractory | 21.47 | 17.48 | 11 | 29384 | 1035 | 50574694 |
Hyperamylasaemia | 21.45 | 17.48 | 8 | 29387 | 348 | 50575381 |
Intentional overdose | 21.41 | 17.48 | 5 | 29390 | 62499 | 50513230 |
Pseudomonal sepsis | 21.35 | 17.48 | 14 | 29381 | 2093 | 50573636 |
Exfoliative rash | 21.32 | 17.48 | 15 | 29380 | 2515 | 50573214 |
Clostridial infection | 21.22 | 17.48 | 18 | 29377 | 3972 | 50571757 |
Endocarditis | 21.14 | 17.48 | 20 | 29375 | 5087 | 50570642 |
Sepsis syndrome | 21.00 | 17.48 | 10 | 29385 | 803 | 50574926 |
Premature delivery | 20.96 | 17.48 | 44 | 29351 | 23619 | 50552110 |
Anisocytosis | 20.89 | 17.48 | 9 | 29386 | 572 | 50575157 |
Bronchitis | 20.71 | 17.48 | 18 | 29377 | 104141 | 50471588 |
Candida endophthalmitis | 20.67 | 17.48 | 5 | 29390 | 46 | 50575683 |
Bacterial sepsis | 20.67 | 17.48 | 17 | 29378 | 3595 | 50572134 |
Hydrocephalus | 20.30 | 17.48 | 19 | 29376 | 4769 | 50570960 |
Venoocclusive liver disease | 20.19 | 17.48 | 18 | 29377 | 4243 | 50571486 |
Hepatosplenomegaly | 20.16 | 17.48 | 14 | 29381 | 2298 | 50573431 |
Cardiac failure congestive | 20.15 | 17.48 | 12 | 29383 | 84370 | 50491359 |
Mediastinal effusion | 20.03 | 17.48 | 5 | 29390 | 53 | 50575676 |
Antibiotic level above therapeutic | 20.01 | 17.48 | 7 | 29388 | 253 | 50575476 |
Blood fibrinogen decreased | 19.91 | 17.48 | 9 | 29386 | 642 | 50575087 |
Suicidal ideation | 19.85 | 17.48 | 4 | 29391 | 55381 | 50520348 |
Blood cholesterol increased | 19.76 | 17.48 | 4 | 29391 | 55211 | 50520518 |
Abdominal sepsis | 19.75 | 17.48 | 11 | 29384 | 1224 | 50574505 |
Coagulation test abnormal | 19.58 | 17.48 | 9 | 29386 | 667 | 50575062 |
Enterococcal bacteraemia | 19.56 | 17.48 | 11 | 29384 | 1247 | 50574482 |
Low cardiac output syndrome | 19.52 | 17.48 | 7 | 29388 | 272 | 50575457 |
Klebsiella bacteraemia | 19.41 | 17.48 | 11 | 29384 | 1266 | 50574463 |
Septal panniculitis | 19.39 | 17.48 | 5 | 29390 | 61 | 50575668 |
Acute graft versus host disease in intestine | 19.36 | 17.48 | 12 | 29383 | 1627 | 50574102 |
Injection site reaction | 19.26 | 17.48 | 3 | 29392 | 50029 | 50525700 |
Myoclonus | 19.20 | 17.48 | 32 | 29363 | 14438 | 50561291 |
Clostridium test positive | 19.14 | 17.48 | 13 | 29382 | 2059 | 50573670 |
Musculoskeletal pain | 19.10 | 17.48 | 9 | 29386 | 72168 | 50503561 |
Wound haemorrhage | 19.04 | 17.48 | 13 | 29382 | 2077 | 50573652 |
Cytomegalovirus infection | 19.03 | 17.48 | 36 | 29359 | 17926 | 50557803 |
Serum sickness | 19.02 | 17.48 | 14 | 29381 | 2518 | 50573211 |
Acute graft versus host disease in skin | 18.96 | 17.48 | 15 | 29380 | 3003 | 50572726 |
Leukocytosis | 18.86 | 17.48 | 41 | 29354 | 22538 | 50553191 |
Herpes simplex | 18.81 | 17.48 | 22 | 29373 | 7140 | 50568589 |
Cytomegalovirus test positive | 18.73 | 17.48 | 14 | 29381 | 2578 | 50573151 |
Hospitalisation | 18.71 | 17.48 | 8 | 29387 | 67929 | 50507800 |
Immunosuppressant drug level increased | 18.68 | 17.48 | 15 | 29380 | 3067 | 50572662 |
Hyperammonaemia | 18.61 | 17.48 | 18 | 29377 | 4706 | 50571023 |
Influenza | 18.38 | 17.48 | 15 | 29380 | 89523 | 50486206 |
Encephalitis | 18.27 | 17.48 | 22 | 29373 | 7358 | 50568371 |
Thrombotic microangiopathy | 18.25 | 17.48 | 24 | 29371 | 8767 | 50566962 |
Systemic mycosis | 18.17 | 17.48 | 10 | 29385 | 1087 | 50574642 |
Abdominal compartment syndrome | 18.14 | 17.48 | 8 | 29387 | 538 | 50575191 |
Fusarium infection | 18.09 | 17.48 | 8 | 29387 | 542 | 50575187 |
Cerebrovascular accident | 18.06 | 17.48 | 17 | 29378 | 94663 | 50481066 |
Liver disorder | 17.99 | 17.48 | 55 | 29340 | 37167 | 50538562 |
Pulseless electrical activity | 17.94 | 17.48 | 21 | 29374 | 6820 | 50568909 |
Rhinorrhoea | 17.92 | 17.48 | 4 | 29391 | 51579 | 50524150 |
Calcification of muscle | 17.90 | 17.48 | 4 | 29391 | 25 | 50575704 |
Generalised tonic-clonic seizure | 17.83 | 17.48 | 44 | 29351 | 26266 | 50549463 |
Cardiomyopathy acute | 17.75 | 17.48 | 6 | 29389 | 195 | 50575534 |
Immune effector cell-associated neurotoxicity syndrome | 17.73 | 17.48 | 10 | 29385 | 1140 | 50574589 |
Vision blurred | 17.66 | 17.48 | 12 | 29383 | 78635 | 50497094 |
Hypokalaemia | 17.60 | 17.48 | 99 | 29296 | 87893 | 50487836 |
Clostridial sepsis | 17.51 | 17.48 | 7 | 29388 | 368 | 50575361 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Multiple organ dysfunction syndrome | 486.72 | 14.92 | 501 | 38227 | 62615 | 29473184 |
Septic shock | 454.40 | 14.92 | 481 | 38247 | 62079 | 29473720 |
Drug resistance | 346.39 | 14.92 | 260 | 38468 | 21280 | 29514519 |
Pathogen resistance | 337.47 | 14.92 | 179 | 38549 | 7937 | 29527862 |
Drug reaction with eosinophilia and systemic symptoms | 304.51 | 14.92 | 269 | 38459 | 27723 | 29508076 |
Bronchopulmonary aspergillosis | 220.92 | 14.92 | 159 | 38569 | 12185 | 29523614 |
Drug ineffective | 209.70 | 14.92 | 983 | 37745 | 362187 | 29173612 |
Sepsis | 178.31 | 14.92 | 498 | 38230 | 142184 | 29393615 |
Enterococcal infection | 174.84 | 14.92 | 118 | 38610 | 8150 | 29527649 |
Fatigue | 173.89 | 14.92 | 100 | 38628 | 316721 | 29219078 |
Candida infection | 172.86 | 14.92 | 150 | 38578 | 15075 | 29520724 |
Respiratory failure | 169.46 | 14.92 | 385 | 38343 | 96746 | 29439053 |
Off label use | 162.15 | 14.92 | 799 | 37929 | 300001 | 29235798 |
Pyrexia | 160.74 | 14.92 | 772 | 37956 | 286850 | 29248949 |
Disseminated intravascular coagulation | 157.94 | 14.92 | 161 | 38567 | 19819 | 29515980 |
Eosinophilia | 152.77 | 14.92 | 166 | 38562 | 21995 | 29513804 |
Haemophagocytic lymphohistiocytosis | 147.36 | 14.92 | 117 | 38611 | 10387 | 29525412 |
Hepatic function abnormal | 144.38 | 14.92 | 215 | 38513 | 39044 | 29496755 |
Dizziness | 139.62 | 14.92 | 38 | 38690 | 189646 | 29346153 |
Fall | 127.58 | 14.92 | 37 | 38691 | 177141 | 29358658 |
Klebsiella infection | 125.41 | 14.92 | 92 | 38636 | 7257 | 29528542 |
Rash maculo-papular | 122.48 | 14.92 | 155 | 38573 | 24134 | 29511665 |
Systemic candida | 109.02 | 14.92 | 59 | 38669 | 2721 | 29533078 |
Product dose omission issue | 105.26 | 14.92 | 5 | 38723 | 96378 | 29439421 |
Toxic epidermal necrolysis | 99.80 | 14.92 | 121 | 38607 | 18032 | 29517767 |
Pseudomonas infection | 90.41 | 14.92 | 90 | 38638 | 10762 | 29525037 |
Pancytopenia | 89.92 | 14.92 | 276 | 38452 | 82892 | 29452907 |
Aspergillus infection | 88.61 | 14.92 | 88 | 38640 | 10493 | 29525306 |
Thrombocytopenia | 87.61 | 14.92 | 379 | 38349 | 134444 | 29401355 |
Myocardial infarction | 87.10 | 14.92 | 19 | 38709 | 110277 | 29425522 |
Drug abuse | 84.53 | 14.92 | 5 | 38723 | 79878 | 29455921 |
Death | 83.48 | 14.92 | 205 | 38523 | 341879 | 29193920 |
Geotrichum infection | 81.02 | 14.92 | 28 | 38700 | 417 | 29535382 |
Drug ineffective for unapproved indication | 78.54 | 14.92 | 95 | 38633 | 14119 | 29521680 |
Pain | 78.02 | 14.92 | 66 | 38662 | 171366 | 29364433 |
Herpes simplex oesophagitis | 74.17 | 14.92 | 20 | 38708 | 119 | 29535680 |
Dysbiosis | 72.29 | 14.92 | 25 | 38703 | 373 | 29535426 |
Acute respiratory distress syndrome | 70.88 | 14.92 | 116 | 38612 | 22819 | 29512980 |
Bone marrow failure | 70.62 | 14.92 | 128 | 38600 | 27321 | 29508478 |
Headache | 68.71 | 14.92 | 76 | 38652 | 173931 | 29361868 |
Febrile neutropenia | 67.92 | 14.92 | 309 | 38419 | 111931 | 29423868 |
Renal impairment | 65.02 | 14.92 | 244 | 38484 | 81089 | 29454710 |
Arthralgia | 64.42 | 14.92 | 53 | 38675 | 139564 | 29396235 |
Depression | 62.64 | 14.92 | 17 | 38711 | 85130 | 29450669 |
Asthenia | 61.47 | 14.92 | 118 | 38610 | 215132 | 29320667 |
Fungaemia | 60.65 | 14.92 | 37 | 38691 | 2144 | 29533655 |
Drug-induced liver injury | 59.58 | 14.92 | 104 | 38624 | 21551 | 29514248 |
Pseudomembranous colitis | 59.56 | 14.92 | 39 | 38689 | 2558 | 29533241 |
Anxiety | 59.23 | 14.92 | 19 | 38709 | 85346 | 29450453 |
Mucormycosis | 58.88 | 14.92 | 51 | 38677 | 5107 | 29530692 |
Stenotrophomonas infection | 57.91 | 14.92 | 33 | 38695 | 1684 | 29534115 |
Trichosporon infection | 57.36 | 14.92 | 24 | 38704 | 616 | 29535183 |
Back pain | 56.26 | 14.92 | 32 | 38696 | 102252 | 29433547 |
Inflammatory marker increased | 56.08 | 14.92 | 43 | 38685 | 3624 | 29532175 |
Cholestasis | 56.07 | 14.92 | 106 | 38622 | 23356 | 29512443 |
Spinal muscular atrophy | 55.92 | 14.92 | 19 | 38709 | 268 | 29535531 |
Pain in extremity | 54.65 | 14.92 | 39 | 38689 | 110394 | 29425405 |
Pneumonia bacterial | 54.16 | 14.92 | 64 | 38664 | 9279 | 29526520 |
Weight decreased | 54.14 | 14.92 | 71 | 38657 | 150834 | 29384965 |
Hyphaema | 52.98 | 14.92 | 21 | 38707 | 467 | 29535332 |
Hepatomegaly | 52.66 | 14.92 | 63 | 38665 | 9254 | 29526545 |
Agranulocytosis | 51.23 | 14.92 | 94 | 38634 | 20246 | 29515553 |
Clostridium difficile colitis | 50.89 | 14.92 | 74 | 38654 | 13138 | 29522661 |
Pneumococcal sepsis | 50.40 | 14.92 | 24 | 38704 | 842 | 29534957 |
Clostridium difficile infection | 49.00 | 14.92 | 81 | 38647 | 16060 | 29519739 |
Liver injury | 48.76 | 14.92 | 71 | 38657 | 12619 | 29523180 |
Blood pressure increased | 48.47 | 14.92 | 18 | 38710 | 73785 | 29462014 |
Feeling abnormal | 48.10 | 14.92 | 7 | 38721 | 54438 | 29481361 |
Joint swelling | 47.21 | 14.92 | 5 | 38723 | 49625 | 29486174 |
Drug eruption | 46.83 | 14.92 | 81 | 38647 | 16660 | 29519139 |
Pulmonary haemorrhage | 46.45 | 14.92 | 59 | 38669 | 9211 | 29526588 |
Inappropriate schedule of product administration | 46.38 | 14.92 | 3 | 38725 | 44469 | 29491330 |
Tachypnoea | 46.08 | 14.92 | 76 | 38652 | 15039 | 29520760 |
Nausea | 45.88 | 14.92 | 209 | 38519 | 289046 | 29246753 |
Myalgia | 45.44 | 14.92 | 20 | 38708 | 73999 | 29461800 |
Cardiac failure congestive | 44.99 | 14.92 | 22 | 38706 | 76559 | 29459240 |
Product use in unapproved indication | 44.44 | 14.92 | 228 | 38500 | 86647 | 29449152 |
Systemic mycosis | 43.51 | 14.92 | 25 | 38703 | 1296 | 29534503 |
Gait disturbance | 43.20 | 14.92 | 21 | 38707 | 73328 | 29462471 |
Muscle spasms | 42.52 | 14.92 | 16 | 38712 | 65066 | 29470733 |
Pneumothorax | 42.17 | 14.92 | 75 | 38653 | 15767 | 29520032 |
Fungal infection | 41.98 | 14.92 | 69 | 38659 | 13616 | 29522183 |
Aplastic anaemia | 41.16 | 14.92 | 50 | 38678 | 7460 | 29528339 |
Coagulopathy | 40.44 | 14.92 | 79 | 38649 | 17828 | 29517971 |
Brain abscess | 40.31 | 14.92 | 31 | 38697 | 2624 | 29533175 |
Hepatic failure | 39.18 | 14.92 | 110 | 38618 | 31402 | 29504397 |
Chest pain | 38.80 | 14.92 | 54 | 38674 | 111919 | 29423880 |
Hypoalbuminaemia | 38.64 | 14.92 | 57 | 38671 | 10248 | 29525551 |
Enterococcus test positive | 38.64 | 14.92 | 19 | 38709 | 716 | 29535083 |
Coronary artery disease | 38.30 | 14.92 | 6 | 38722 | 44184 | 29491615 |
Hypofibrinogenaemia | 38.03 | 14.92 | 24 | 38704 | 1477 | 29534322 |
Hyperhidrosis | 37.21 | 14.92 | 19 | 38709 | 64521 | 29471278 |
Sputum increased | 37.18 | 14.92 | 26 | 38702 | 1901 | 29533898 |
Leukopenia | 37.15 | 14.92 | 157 | 38571 | 55046 | 29480753 |
Nasopharyngitis | 36.81 | 14.92 | 16 | 38712 | 59649 | 29476150 |
Weight increased | 36.71 | 14.92 | 28 | 38700 | 76639 | 29459160 |
Syncope | 36.13 | 14.92 | 32 | 38696 | 81339 | 29454460 |
Respiratory tract infection bacterial | 35.71 | 14.92 | 17 | 38711 | 596 | 29535203 |
Cough | 35.65 | 14.92 | 70 | 38658 | 126657 | 29409142 |
Portal fibrosis | 35.50 | 14.92 | 14 | 38714 | 307 | 29535492 |
Acinetobacter infection | 35.43 | 14.92 | 20 | 38708 | 1002 | 29534797 |
Acute generalised exanthematous pustulosis | 35.31 | 14.92 | 40 | 38688 | 5543 | 29530256 |
Hyperferritinaemia | 34.80 | 14.92 | 14 | 38714 | 324 | 29535475 |
Ototoxicity | 34.67 | 14.92 | 23 | 38705 | 1542 | 29534257 |
Dyspnoea | 33.88 | 14.92 | 270 | 38458 | 326462 | 29209337 |
C-reactive protein increased | 33.85 | 14.92 | 131 | 38597 | 44132 | 29491667 |
Serum sickness-like reaction | 33.10 | 14.92 | 10 | 38718 | 94 | 29535705 |
Tubulointerstitial nephritis | 32.98 | 14.92 | 72 | 38656 | 17571 | 29518228 |
Enterocolitis | 32.73 | 14.92 | 42 | 38686 | 6624 | 29529175 |
Abdominal discomfort | 32.61 | 14.92 | 11 | 38717 | 47892 | 29487907 |
Hepatotoxicity | 32.36 | 14.92 | 72 | 38656 | 17795 | 29518004 |
Hospitalisation | 32.30 | 14.92 | 10 | 38718 | 45978 | 29489821 |
Treatment failure | 32.16 | 14.92 | 114 | 38614 | 36825 | 29498974 |
Increased bronchial secretion | 32.07 | 14.92 | 22 | 38706 | 1559 | 29534240 |
Intentional overdose | 31.70 | 14.92 | 6 | 38722 | 38522 | 29497277 |
Rectal haemorrhage | 31.56 | 14.92 | 4 | 38724 | 34545 | 29501254 |
Cross sensitivity reaction | 31.53 | 14.92 | 20 | 38708 | 1242 | 29534557 |
Myelosuppression | 31.41 | 14.92 | 57 | 38671 | 12170 | 29523629 |
Hypoxia | 31.29 | 14.92 | 134 | 38594 | 47245 | 29488554 |
Respiratory gas exchange disorder | 31.21 | 14.92 | 14 | 38714 | 427 | 29535372 |
Rheumatoid arthritis | 31.20 | 14.92 | 3 | 38725 | 32149 | 29503650 |
Shock | 30.92 | 14.92 | 79 | 38649 | 21325 | 29514474 |
Cryptococcal meningoencephalitis | 30.90 | 14.92 | 10 | 38718 | 120 | 29535679 |
Liver abscess | 30.26 | 14.92 | 29 | 38699 | 3309 | 29532490 |
Bacteraemia | 29.81 | 14.92 | 66 | 38662 | 16257 | 29519542 |
Incorrect dose administered | 29.70 | 14.92 | 4 | 38724 | 32980 | 29502819 |
Vision blurred | 29.57 | 14.92 | 8 | 38720 | 40168 | 29495631 |
Neutropenia | 29.28 | 14.92 | 282 | 38446 | 131429 | 29404370 |
Dehydration | 29.24 | 14.92 | 67 | 38661 | 114681 | 29421118 |
Rash morbilliform | 29.16 | 14.92 | 25 | 38703 | 2468 | 29533331 |
Procalcitonin increased | 29.01 | 14.92 | 21 | 38707 | 1621 | 29534178 |
Encephalopathy | 28.93 | 14.92 | 98 | 38630 | 30945 | 29504854 |
Cytomegalovirus infection | 28.81 | 14.92 | 81 | 38647 | 23134 | 29512665 |
Cytokine release syndrome | 28.56 | 14.92 | 57 | 38671 | 13062 | 29522737 |
Venoocclusive liver disease | 28.48 | 14.92 | 40 | 38688 | 6877 | 29528922 |
Musculoskeletal stiffness | 28.45 | 14.92 | 7 | 38721 | 37451 | 29498348 |
Clostridium test positive | 28.44 | 14.92 | 23 | 38705 | 2094 | 29533705 |
Platelet count decreased | 28.34 | 14.92 | 234 | 38494 | 104438 | 29431361 |
Therapeutic product effect decreased | 27.92 | 14.92 | 3 | 38725 | 29448 | 29506351 |
Wrong technique in product usage process | 27.85 | 14.92 | 4 | 38724 | 31424 | 29504375 |
Neutropenic colitis | 27.84 | 14.92 | 24 | 38704 | 2387 | 29533412 |
Epidermolysis bullosa | 27.81 | 14.92 | 9 | 38719 | 108 | 29535691 |
Insomnia | 27.66 | 14.92 | 46 | 38682 | 88715 | 29447084 |
Vomiting | 27.60 | 14.92 | 164 | 38564 | 212096 | 29323703 |
Oedema peripheral | 27.58 | 14.92 | 59 | 38669 | 103498 | 29432301 |
Dermatitis bullous | 27.11 | 14.92 | 36 | 38692 | 5870 | 29529929 |
Balance disorder | 27.00 | 14.92 | 7 | 38721 | 36163 | 29499636 |
Cerebrovascular accident | 26.72 | 14.92 | 37 | 38691 | 76874 | 29458925 |
Granulocyte count decreased | 26.59 | 14.92 | 14 | 38714 | 610 | 29535189 |
Endocarditis | 26.48 | 14.92 | 35 | 38693 | 5681 | 29530118 |
Constipation | 26.46 | 14.92 | 70 | 38658 | 114090 | 29421709 |
Tumour lysis syndrome | 26.33 | 14.92 | 57 | 38671 | 13827 | 29521972 |
Eosinophilic pneumonia | 26.32 | 14.92 | 25 | 38703 | 2821 | 29532978 |
Aggression | 26.30 | 14.92 | 7 | 38721 | 35534 | 29500265 |
Acute myeloid leukaemia | 26.01 | 14.92 | 63 | 38665 | 16450 | 29519349 |
Renal failure | 25.40 | 14.92 | 252 | 38476 | 118347 | 29417452 |
Condition aggravated | 25.38 | 14.92 | 298 | 38430 | 145997 | 29389802 |
Blood glucose increased | 25.22 | 14.92 | 24 | 38704 | 58960 | 29476839 |
CNS ventriculitis | 25.16 | 14.92 | 10 | 38718 | 224 | 29535575 |
Vascular pseudoaneurysm thrombosis | 25.11 | 14.92 | 7 | 38721 | 48 | 29535751 |
Aortoenteric fistula | 24.88 | 14.92 | 8 | 38720 | 94 | 29535705 |
Toxicity to various agents | 24.84 | 14.92 | 130 | 38598 | 173531 | 29362268 |
Pneumonia fungal | 24.67 | 14.92 | 34 | 38694 | 5743 | 29530056 |
Factor V inhibition | 24.37 | 14.92 | 9 | 38719 | 164 | 29535635 |
Cardiac valve vegetation | 24.29 | 14.92 | 12 | 38716 | 457 | 29535342 |
Transaminases increased | 24.24 | 14.92 | 75 | 38653 | 22587 | 29513212 |
Motor neurone disease | 24.03 | 14.92 | 11 | 38717 | 352 | 29535447 |
Drug intolerance | 24.02 | 14.92 | 17 | 38711 | 48362 | 29487437 |
Stevens-Johnson syndrome | 23.94 | 14.92 | 61 | 38667 | 16436 | 29519363 |
Dyspnoea exertional | 23.78 | 14.92 | 9 | 38719 | 36481 | 29499318 |
Hypertension | 23.75 | 14.92 | 76 | 38652 | 116538 | 29419261 |
Respiratory paralysis | 23.74 | 14.92 | 7 | 38721 | 60 | 29535739 |
Chest X-ray abnormal | 23.68 | 14.92 | 27 | 38701 | 3767 | 29532032 |
Liver disorder | 23.60 | 14.92 | 85 | 38643 | 27664 | 29508135 |
Intentional product misuse | 23.52 | 14.92 | 8 | 38720 | 34653 | 29501146 |
Stoma closure | 23.47 | 14.92 | 8 | 38720 | 114 | 29535685 |
Interleukin-2 receptor increased | 23.47 | 14.92 | 8 | 38720 | 114 | 29535685 |
Neurotoxicity | 23.29 | 14.92 | 56 | 38672 | 14557 | 29521242 |
Wound dehiscence | 23.26 | 14.92 | 24 | 38704 | 2993 | 29532806 |
Contusion | 23.25 | 14.92 | 6 | 38722 | 31089 | 29504710 |
Multiple-drug resistance | 23.07 | 14.92 | 27 | 38701 | 3873 | 29531926 |
Disseminated cryptococcosis | 22.97 | 14.92 | 16 | 38712 | 1162 | 29534637 |
Ischaemic cerebral infarction | 22.82 | 14.92 | 15 | 38713 | 990 | 29534809 |
Peripheral swelling | 22.81 | 14.92 | 30 | 38698 | 63709 | 29472090 |
Shock haemorrhagic | 22.62 | 14.92 | 43 | 38685 | 9508 | 29526291 |
Haemorrhagic pneumonia | 22.62 | 14.92 | 8 | 38720 | 128 | 29535671 |
Acute respiratory failure | 22.56 | 14.92 | 81 | 38647 | 26321 | 29509478 |
Acute kidney injury | 22.50 | 14.92 | 479 | 38249 | 264788 | 29271011 |
Blood alkaline phosphatase increased | 22.47 | 14.92 | 85 | 38643 | 28321 | 29507478 |
Staphylococcal sepsis | 22.36 | 14.92 | 41 | 38687 | 8821 | 29526978 |
Chronic obstructive pulmonary disease | 22.23 | 14.92 | 13 | 38715 | 40942 | 29494857 |
Aspergillus test positive | 22.16 | 14.92 | 11 | 38717 | 423 | 29535376 |
Disease complication | 22.14 | 14.92 | 21 | 38707 | 2365 | 29533434 |
Nosocomial infection | 22.12 | 14.92 | 15 | 38713 | 1043 | 29534756 |
Circulatory collapse | 22.05 | 14.92 | 64 | 38664 | 18609 | 29517190 |
Lung consolidation | 22.02 | 14.92 | 30 | 38698 | 5013 | 29530786 |
Faeces pale | 22.01 | 14.92 | 16 | 38712 | 1243 | 29534556 |
Suicidal ideation | 21.90 | 14.92 | 9 | 38719 | 34707 | 29501092 |
Gastrooesophageal reflux disease | 21.84 | 14.92 | 7 | 38721 | 31489 | 29504310 |
Hepatic necrosis | 21.76 | 14.92 | 25 | 38703 | 3517 | 29532282 |
Leukocytosis | 21.72 | 14.92 | 69 | 38659 | 21073 | 29514726 |
Nocardiosis | 21.71 | 14.92 | 24 | 38704 | 3236 | 29532563 |
Blood bilirubin increased | 21.71 | 14.92 | 95 | 38633 | 33798 | 29502001 |
Epilepsy | 21.60 | 14.92 | 63 | 38665 | 18369 | 29517430 |
Deep vein thrombosis | 21.59 | 14.92 | 26 | 38702 | 57373 | 29478426 |
Hepatic cytolysis | 21.55 | 14.92 | 39 | 38689 | 8308 | 29527491 |
Immune effector cell-associated neurotoxicity syndrome | 21.42 | 14.92 | 17 | 38711 | 1507 | 29534292 |
Mobility decreased | 21.24 | 14.92 | 4 | 38724 | 25776 | 29510023 |
Eosinophilic pneumonia acute | 21.22 | 14.92 | 11 | 38717 | 464 | 29535335 |
Dysarthria | 21.21 | 14.92 | 7 | 38721 | 30904 | 29504895 |
Injection site pain | 21.15 | 14.92 | 8 | 38720 | 32438 | 29503361 |
Acute myeloid leukaemia recurrent | 21.13 | 14.92 | 18 | 38710 | 1762 | 29534037 |
Rhinocerebral mucormycosis | 21.12 | 14.92 | 9 | 38719 | 242 | 29535557 |
Nephrogenic diabetes insipidus | 21.12 | 14.92 | 15 | 38713 | 1124 | 29534675 |
Urinary tract infection fungal | 20.94 | 14.92 | 10 | 38718 | 353 | 29535446 |
Aeromonas infection | 20.91 | 14.92 | 9 | 38719 | 248 | 29535551 |
Metabolic disorder | 20.90 | 14.92 | 25 | 38703 | 3670 | 29532129 |
Intestinal ischaemia | 20.87 | 14.92 | 34 | 38694 | 6658 | 29529141 |
Paraesthesia | 20.67 | 14.92 | 24 | 38704 | 53821 | 29481978 |
Candida test positive | 20.58 | 14.92 | 10 | 38718 | 367 | 29535432 |
Transient ischaemic attack | 20.53 | 14.92 | 3 | 38725 | 23267 | 29512532 |
Alanine aminotransferase increased | 20.49 | 14.92 | 161 | 38567 | 70783 | 29465016 |
Arthritis | 20.36 | 14.92 | 4 | 38724 | 25015 | 29510784 |
Dyspepsia | 20.36 | 14.92 | 7 | 38721 | 30118 | 29505681 |
Dermatitis exfoliative generalised | 20.35 | 14.92 | 22 | 38706 | 2894 | 29532905 |
Resuscitation | 20.28 | 14.92 | 15 | 38713 | 1197 | 29534602 |
Heart rate decreased | 20.24 | 14.92 | 4 | 38724 | 24908 | 29510891 |
Antinuclear antibody negative | 20.18 | 14.92 | 5 | 38723 | 20 | 29535779 |
Radiation fibrosis - lung | 19.98 | 14.92 | 5 | 38723 | 21 | 29535778 |
Haemodynamic instability | 19.93 | 14.92 | 37 | 38691 | 8036 | 29527763 |
Pneumonia | 19.88 | 14.92 | 554 | 38174 | 319618 | 29216181 |
Septic embolus | 19.87 | 14.92 | 14 | 38714 | 1036 | 29534763 |
Drug level decreased | 19.84 | 14.92 | 32 | 38696 | 6215 | 29529584 |
Angina pectoris | 19.65 | 14.92 | 6 | 38722 | 27844 | 29507955 |
Sleep disorder | 19.63 | 14.92 | 4 | 38724 | 24382 | 29511417 |
Toxic skin eruption | 19.59 | 14.92 | 41 | 38687 | 9716 | 29526083 |
Staphylococcal infection | 19.53 | 14.92 | 83 | 38645 | 29157 | 29506642 |
Necrotising fasciitis | 19.42 | 14.92 | 23 | 38705 | 3342 | 29532457 |
Hypokalaemia | 19.21 | 14.92 | 122 | 38606 | 50081 | 29485718 |
Intra-abdominal fluid collection | 19.11 | 14.92 | 14 | 38714 | 1101 | 29534698 |
Strongyloidiasis | 18.93 | 14.92 | 19 | 38709 | 2293 | 29533506 |
Hepatitis cholestatic | 18.81 | 14.92 | 33 | 38695 | 6860 | 29528939 |
Lower respiratory tract infection bacterial | 18.79 | 14.92 | 9 | 38719 | 320 | 29535479 |
Nephrolithiasis | 18.72 | 14.92 | 5 | 38723 | 25329 | 29510470 |
Chimerism | 18.50 | 14.92 | 8 | 38720 | 223 | 29535576 |
Type IV hypersensitivity reaction | 18.47 | 14.92 | 14 | 38714 | 1160 | 29534639 |
Hyperbilirubinaemia | 18.42 | 14.92 | 52 | 38676 | 14882 | 29520917 |
Hypoaesthesia | 18.28 | 14.92 | 26 | 38702 | 53441 | 29482358 |
Loss of consciousness | 18.24 | 14.92 | 44 | 38684 | 74012 | 29461787 |
Acute hepatic failure | 18.19 | 14.92 | 45 | 38683 | 11907 | 29523892 |
Fungal sepsis | 18.19 | 14.92 | 12 | 38716 | 797 | 29535002 |
Lymphadenectomy | 18.15 | 14.92 | 8 | 38720 | 234 | 29535565 |
Mediastinitis | 18.14 | 14.92 | 11 | 38717 | 630 | 29535169 |
Coagulation time prolonged | 18.09 | 14.92 | 14 | 38714 | 1196 | 29534603 |
Myasthenia gravis crisis | 18.09 | 14.92 | 10 | 38718 | 481 | 29535318 |
Asthma | 18.01 | 14.92 | 11 | 38717 | 33838 | 29501961 |
Myocardial calcification | 17.97 | 14.92 | 5 | 38723 | 34 | 29535765 |
Flavobacterium infection | 17.97 | 14.92 | 6 | 38722 | 80 | 29535719 |
ADAMTS13 activity decreased | 17.90 | 14.92 | 6 | 38722 | 81 | 29535718 |
Drug interaction | 17.88 | 14.92 | 360 | 38368 | 197025 | 29338774 |
Tremor | 17.87 | 14.92 | 44 | 38684 | 73494 | 29462305 |
Infective aneurysm | 17.86 | 14.92 | 10 | 38718 | 493 | 29535306 |
Dermatitis exfoliative | 17.85 | 14.92 | 31 | 38697 | 6394 | 29529405 |
Malaise | 17.84 | 14.92 | 129 | 38599 | 159473 | 29376326 |
Vascular pseudoaneurysm | 17.79 | 14.92 | 17 | 38711 | 1932 | 29533867 |
Decreased appetite | 17.46 | 14.92 | 115 | 38613 | 145227 | 29390572 |
Enterococcal sepsis | 17.44 | 14.92 | 15 | 38713 | 1487 | 29534312 |
Potentiating drug interaction | 17.29 | 14.92 | 25 | 38703 | 4413 | 29531386 |
Gamma-glutamyltransferase increased | 17.17 | 14.92 | 75 | 38653 | 26662 | 29509137 |
Chest discomfort | 17.11 | 14.92 | 21 | 38707 | 45962 | 29489837 |
Rectal perforation | 17.06 | 14.92 | 9 | 38719 | 394 | 29535405 |
Soft tissue necrosis | 17.03 | 14.92 | 8 | 38720 | 272 | 29535527 |
Overdose | 16.96 | 14.92 | 51 | 38677 | 79768 | 29456031 |
Device related infection | 16.95 | 14.92 | 52 | 38676 | 15584 | 29520215 |
Cardiac arrest | 16.94 | 14.92 | 179 | 38549 | 85412 | 29450387 |
Candida sepsis | 16.80 | 14.92 | 13 | 38715 | 1110 | 29534689 |
Graft versus host disease in gastrointestinal tract | 16.74 | 14.92 | 21 | 38707 | 3237 | 29532562 |
Dry mouth | 16.68 | 14.92 | 4 | 38724 | 21780 | 29514019 |
Blood lactate dehydrogenase increased | 16.47 | 14.92 | 59 | 38669 | 19150 | 29516649 |
Bronchial disorder | 16.42 | 14.92 | 13 | 38715 | 1148 | 29534651 |
Catheter site pain | 16.39 | 14.92 | 13 | 38715 | 1151 | 29534648 |
Staphylococcus test positive | 16.30 | 14.92 | 19 | 38709 | 2714 | 29533085 |
Splenomegaly | 16.15 | 14.92 | 46 | 38682 | 13233 | 29522566 |
Scedosporium infection | 16.10 | 14.92 | 11 | 38717 | 774 | 29535025 |
Candida pneumonia | 16.09 | 14.92 | 8 | 38720 | 309 | 29535490 |
Influenza like illness | 16 | 14.92 | 6 | 38722 | 24464 | 29511335 |
Mechanical ventilation | 16.00 | 14.92 | 15 | 38713 | 1665 | 29534134 |
Hypernatraemia | 15.97 | 14.92 | 32 | 38696 | 7354 | 29528445 |
Amnesia | 15.76 | 14.92 | 5 | 38723 | 22638 | 29513161 |
Macule | 15.73 | 14.92 | 12 | 38716 | 1004 | 29534795 |
Linear IgA disease | 15.71 | 14.92 | 14 | 38714 | 1455 | 29534344 |
Drug level increased | 15.51 | 14.92 | 57 | 38671 | 18730 | 29517069 |
Systemic inflammatory response syndrome | 15.51 | 14.92 | 28 | 38700 | 5953 | 29529846 |
Hypoproteinaemia | 15.46 | 14.92 | 15 | 38713 | 1737 | 29534062 |
Escherichia infection | 15.46 | 14.92 | 30 | 38698 | 6734 | 29529065 |
Graft versus host disease | 15.45 | 14.92 | 37 | 38691 | 9591 | 29526208 |
Alveolitis necrotising | 15.42 | 14.92 | 4 | 38724 | 20 | 29535779 |
Red blood cell sedimentation rate decreased | 15.38 | 14.92 | 5 | 38723 | 61 | 29535738 |
Cholangiolitis | 15.26 | 14.92 | 4 | 38724 | 21 | 29535778 |
Intestinal pseudo-obstruction | 15.24 | 14.92 | 13 | 38715 | 1275 | 29534524 |
Hypovolaemic shock | 15.21 | 14.92 | 28 | 38700 | 6044 | 29529755 |
Pneumonia klebsiella | 15.14 | 14.92 | 18 | 38710 | 2626 | 29533173 |
Endotracheal intubation | 15 | 14.92 | 18 | 38710 | 2651 | 29533148 |
Red blood cell schistocytes present | 14.98 | 14.92 | 7 | 38721 | 235 | 29535564 |
Acute graft versus host disease in skin | 14.96 | 14.92 | 24 | 38704 | 4640 | 29531159 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Multiple organ dysfunction syndrome | 930.89 | 13.80 | 785 | 63308 | 100628 | 64334011 |
Septic shock | 824.37 | 13.80 | 745 | 63348 | 104692 | 64329947 |
Drug resistance | 643.73 | 13.80 | 413 | 63680 | 34689 | 64399950 |
Drug reaction with eosinophilia and systemic symptoms | 625.11 | 13.80 | 480 | 63613 | 53737 | 64380902 |
Pathogen resistance | 585.73 | 13.80 | 274 | 63819 | 12269 | 64422370 |
Sepsis | 364.00 | 13.80 | 744 | 63349 | 229597 | 64205042 |
Bronchopulmonary aspergillosis | 345.89 | 13.80 | 223 | 63870 | 18862 | 64415777 |
Respiratory failure | 317.60 | 13.80 | 572 | 63521 | 160611 | 64274028 |
Pyrexia | 312.94 | 13.80 | 1237 | 62856 | 557407 | 63877232 |
Fatigue | 287.59 | 13.80 | 197 | 63896 | 748533 | 63686106 |
Enterococcal infection | 283.77 | 13.80 | 175 | 63918 | 13691 | 64420948 |
Off label use | 271.39 | 13.80 | 1293 | 62800 | 631513 | 63803126 |
Haemophagocytic lymphohistiocytosis | 269.00 | 13.80 | 185 | 63908 | 17424 | 64417215 |
Pain | 261.29 | 13.80 | 112 | 63981 | 553399 | 63881240 |
Thrombocytopenia | 252.85 | 13.80 | 633 | 63460 | 223168 | 64211471 |
Candida infection | 244.98 | 13.80 | 222 | 63871 | 31197 | 64403442 |
Drug ineffective | 240.37 | 13.80 | 1538 | 62555 | 838709 | 63595930 |
Fall | 226.10 | 13.80 | 67 | 64026 | 416759 | 64017880 |
Eosinophilia | 219.62 | 13.80 | 228 | 63865 | 37848 | 64396791 |
Toxic epidermal necrolysis | 215.18 | 13.80 | 223 | 63870 | 36943 | 64397696 |
Disseminated intravascular coagulation | 214.66 | 13.80 | 209 | 63884 | 32139 | 64402500 |
Headache | 214.22 | 13.80 | 131 | 63962 | 529336 | 63905303 |
Arthralgia | 209.31 | 13.80 | 89 | 64004 | 442171 | 63992468 |
Febrile neutropenia | 195.49 | 13.80 | 515 | 63578 | 187142 | 64247497 |
Dizziness | 195.02 | 13.80 | 92 | 64001 | 430071 | 64004568 |
Pancytopenia | 192.70 | 13.80 | 434 | 63659 | 142875 | 64291764 |
Hepatic function abnormal | 190.57 | 13.80 | 275 | 63818 | 64038 | 64370601 |
Klebsiella infection | 176.12 | 13.80 | 128 | 63965 | 13153 | 64421486 |
Joint swelling | 173.72 | 13.80 | 10 | 64083 | 215372 | 64219267 |
Systemic candida | 173.16 | 13.80 | 91 | 64002 | 5238 | 64429401 |
Pseudomonas infection | 173.09 | 13.80 | 143 | 63950 | 17740 | 64416899 |
Rash maculo-papular | 167.80 | 13.80 | 220 | 63873 | 46806 | 64387833 |
Aspergillus infection | 162.77 | 13.80 | 133 | 63960 | 16246 | 64418393 |
Product dose omission issue | 145.67 | 13.80 | 13 | 64080 | 194734 | 64239905 |
Rheumatoid arthritis | 144.62 | 13.80 | 4 | 64089 | 164290 | 64270349 |
Pain in extremity | 133.91 | 13.80 | 67 | 64026 | 303018 | 64131621 |
Clostridium difficile colitis | 132.39 | 13.80 | 149 | 63944 | 27074 | 64407565 |
Acinetobacter infection | 132.02 | 13.80 | 59 | 64034 | 2370 | 64432269 |
Geotrichum infection | 131.36 | 13.80 | 45 | 64048 | 873 | 64433766 |
Acute respiratory distress syndrome | 129.46 | 13.80 | 176 | 63917 | 38759 | 64395880 |
Acute kidney injury | 123.07 | 13.80 | 815 | 63278 | 448425 | 63986214 |
Renal impairment | 122.06 | 13.80 | 352 | 63741 | 134665 | 64299974 |
Abdominal discomfort | 119.54 | 13.80 | 19 | 64074 | 182303 | 64252336 |
Fungaemia | 118.35 | 13.80 | 63 | 64030 | 3722 | 64430917 |
Dysbiosis | 116.97 | 13.80 | 41 | 64052 | 854 | 64433785 |
Nasopharyngitis | 116.70 | 13.80 | 26 | 64067 | 196047 | 64238592 |
Mucormycosis | 114.16 | 13.80 | 78 | 64015 | 7263 | 64427376 |
Agranulocytosis | 111.06 | 13.80 | 162 | 63931 | 38067 | 64396572 |
Pseudomembranous colitis | 110.74 | 13.80 | 66 | 64027 | 4850 | 64429789 |
Drug abuse | 110.32 | 13.80 | 5 | 64088 | 132369 | 64302270 |
Drug intolerance | 109.74 | 13.80 | 26 | 64067 | 187966 | 64246673 |
Drug ineffective for unapproved indication | 105.42 | 13.80 | 142 | 63951 | 30991 | 64403648 |
Nausea | 102.68 | 13.80 | 418 | 63675 | 785382 | 63649257 |
Peripheral swelling | 100.50 | 13.80 | 41 | 64052 | 209112 | 64225527 |
Neutropenia | 99.33 | 13.80 | 486 | 63607 | 239138 | 64195501 |
Bone marrow failure | 99.13 | 13.80 | 174 | 63919 | 47778 | 64386861 |
Clostridium difficile infection | 98.95 | 13.80 | 149 | 63944 | 36014 | 64398625 |
Stenotrophomonas infection | 98.38 | 13.80 | 52 | 64041 | 3028 | 64431611 |
Weight increased | 97.48 | 13.80 | 45 | 64048 | 213303 | 64221336 |
Depression | 96.42 | 13.80 | 31 | 64062 | 183260 | 64251379 |
Asthenia | 93.65 | 13.80 | 177 | 63916 | 427867 | 64006772 |
Blood pressure increased | 92.89 | 13.80 | 28 | 64065 | 172524 | 64262115 |
Drug eruption | 87.85 | 13.80 | 141 | 63952 | 35995 | 64398644 |
Anxiety | 87.64 | 13.80 | 46 | 64047 | 202603 | 64232036 |
Trichosporon infection | 87.26 | 13.80 | 33 | 64060 | 859 | 64433780 |
Swelling | 86.23 | 13.80 | 26 | 64067 | 160192 | 64274447 |
Myocardial infarction | 85.54 | 13.80 | 29 | 64064 | 165792 | 64268847 |
Therapeutic product effect decreased | 85.42 | 13.80 | 8 | 64085 | 115343 | 64319296 |
Muscle spasms | 85.31 | 13.80 | 18 | 64075 | 141005 | 64293634 |
Gait disturbance | 83.92 | 13.80 | 33 | 64060 | 172122 | 64262517 |
Feeling abnormal | 83.01 | 13.80 | 16 | 64077 | 133586 | 64301053 |
Acute generalised exanthematous pustulosis | 82.50 | 13.80 | 85 | 64008 | 13973 | 64420666 |
Injection site pain | 81.77 | 13.80 | 8 | 64085 | 111400 | 64323239 |
Brain abscess | 81.06 | 13.80 | 51 | 64042 | 4130 | 64430509 |
Weight decreased | 79.85 | 13.80 | 100 | 63993 | 285639 | 64149000 |
Myelosuppression | 78.11 | 13.80 | 107 | 63986 | 23723 | 64410916 |
Pneumothorax | 77.99 | 13.80 | 108 | 63985 | 24190 | 64410449 |
Coagulopathy | 76.84 | 13.80 | 124 | 63969 | 31796 | 64402843 |
Shock | 75.49 | 13.80 | 136 | 63957 | 38104 | 64396535 |
Sinusitis | 74.43 | 13.80 | 26 | 64067 | 145902 | 64288737 |
Fungal infection | 74.33 | 13.80 | 127 | 63966 | 34124 | 64400515 |
Cholestasis | 74.23 | 13.80 | 148 | 63945 | 44724 | 64389915 |
Musculoskeletal stiffness | 73.96 | 13.80 | 16 | 64077 | 123190 | 64311449 |
Platelet count decreased | 72.93 | 13.80 | 345 | 63748 | 167366 | 64267273 |
Pneumonia bacterial | 72.59 | 13.80 | 82 | 64011 | 14953 | 64419686 |
Candida sepsis | 72.25 | 13.80 | 38 | 64055 | 2190 | 64432449 |
Memory impairment | 72.16 | 13.80 | 3 | 64090 | 85679 | 64348960 |
Cytokine release syndrome | 72.04 | 13.80 | 96 | 63997 | 20733 | 64413906 |
Leukopenia | 71.17 | 13.80 | 242 | 63851 | 101000 | 64333639 |
Encephalopathy | 71.12 | 13.80 | 171 | 63922 | 58648 | 64375991 |
Hepatic failure | 70.18 | 13.80 | 164 | 63929 | 55230 | 64379409 |
Malaise | 70.11 | 13.80 | 184 | 63909 | 396063 | 64038576 |
Neutropenic colitis | 69.64 | 13.80 | 48 | 64045 | 4533 | 64430106 |
Enterocolitis | 69.32 | 13.80 | 72 | 64021 | 11946 | 64422693 |
Stevens-Johnson syndrome | 69.13 | 13.80 | 123 | 63970 | 34126 | 64400513 |
Product use in unapproved indication | 68.73 | 13.80 | 352 | 63741 | 176266 | 64258373 |
Alopecia | 68.17 | 13.80 | 40 | 64053 | 165650 | 64268989 |
Pneumonia fungal | 67.74 | 13.80 | 62 | 64031 | 8815 | 64425824 |
Herpes simplex oesophagitis | 67.09 | 13.80 | 20 | 64073 | 242 | 64434397 |
Hyphaema | 66.86 | 13.80 | 25 | 64068 | 630 | 64434009 |
C-reactive protein increased | 66.83 | 13.80 | 227 | 63866 | 94682 | 64339957 |
Contusion | 66.01 | 13.80 | 16 | 64077 | 113949 | 64320690 |
Hypoalbuminaemia | 65.06 | 13.80 | 84 | 64009 | 17590 | 64417049 |
Tubulointerstitial nephritis | 64.97 | 13.80 | 113 | 63980 | 30796 | 64403843 |
Drug-induced liver injury | 64.72 | 13.80 | 145 | 63948 | 47498 | 64387141 |
Renal failure | 64.46 | 13.80 | 353 | 63740 | 181335 | 64253304 |
Insomnia | 64.35 | 13.80 | 61 | 64032 | 197775 | 64236864 |
Bacteraemia | 64.04 | 13.80 | 104 | 63989 | 26807 | 64407832 |
Procalcitonin increased | 62.86 | 13.80 | 36 | 64057 | 2455 | 64432184 |
Inflammatory marker increased | 62.50 | 13.80 | 58 | 64035 | 8393 | 64426246 |
Clostridium test positive | 62.27 | 13.80 | 43 | 64050 | 4072 | 64430567 |
Drug level decreased | 61.18 | 13.80 | 66 | 64027 | 11437 | 64423202 |
Spinal muscular atrophy | 60.62 | 13.80 | 19 | 64074 | 275 | 64434364 |
Acute respiratory failure | 60.18 | 13.80 | 145 | 63948 | 49789 | 64384850 |
Pneumonia | 59.92 | 13.80 | 832 | 63261 | 558744 | 63875895 |
Cardiac arrest | 59.89 | 13.80 | 307 | 63786 | 153757 | 64280882 |
Aplastic anaemia | 58.99 | 13.80 | 71 | 64022 | 13849 | 64420790 |
Psoriasis | 58.79 | 13.80 | 3 | 64090 | 71700 | 64362939 |
Rhinocerebral mucormycosis | 58.58 | 13.80 | 21 | 64072 | 468 | 64434171 |
Intentional overdose | 57.52 | 13.80 | 10 | 64083 | 89934 | 64344705 |
Hyperbilirubinaemia | 57.47 | 13.80 | 87 | 64006 | 21118 | 64413521 |
Liver injury | 57.23 | 13.80 | 105 | 63988 | 29827 | 64404812 |
Factor V inhibition | 56.99 | 13.80 | 19 | 64074 | 338 | 64434301 |
Multiple-drug resistance | 56.75 | 13.80 | 49 | 64044 | 6453 | 64428186 |
Linear IgA disease | 56.71 | 13.80 | 35 | 64058 | 2739 | 64431900 |
Arthritis | 56.59 | 13.80 | 8 | 64085 | 83806 | 64350833 |
Neurotoxicity | 56.06 | 13.80 | 99 | 63994 | 27305 | 64407334 |
Tachypnoea | 55.66 | 13.80 | 97 | 63996 | 26474 | 64408165 |
Liver abscess | 54.83 | 13.80 | 44 | 64049 | 5236 | 64429403 |
Hyperhidrosis | 54.51 | 13.80 | 28 | 64065 | 124892 | 64309747 |
Pulmonary haemorrhage | 54.14 | 13.80 | 66 | 64027 | 13043 | 64421596 |
Back pain | 54.13 | 13.80 | 104 | 63989 | 250067 | 64184572 |
Asthma | 53.93 | 13.80 | 14 | 64079 | 95211 | 64339428 |
Drug interaction | 53.79 | 13.80 | 573 | 63520 | 361510 | 64073129 |
Toxic skin eruption | 53.52 | 13.80 | 80 | 64013 | 19204 | 64415435 |
Inappropriate schedule of product administration | 53.36 | 13.80 | 13 | 64080 | 92273 | 64342366 |
Systemic inflammatory response syndrome | 53.16 | 13.80 | 58 | 64035 | 10177 | 64424462 |
Lung consolidation | 53.08 | 13.80 | 51 | 64042 | 7707 | 64426932 |
Cardiac failure congestive | 53.04 | 13.80 | 32 | 64061 | 130548 | 64304091 |
Eosinophilic pneumonia acute | 52.91 | 13.80 | 23 | 64070 | 864 | 64433775 |
Wound | 52.34 | 13.80 | 7 | 64086 | 76470 | 64358169 |
Acute myeloid leukaemia | 52.08 | 13.80 | 96 | 63997 | 27367 | 64407272 |
Systemic mycosis | 51.84 | 13.80 | 31 | 64062 | 2292 | 64432347 |
Rash morbilliform | 51.60 | 13.80 | 42 | 64051 | 5099 | 64429540 |
Staphylococcal infection | 51.53 | 13.80 | 138 | 63955 | 50540 | 64384099 |
Epilepsy | 51.20 | 13.80 | 107 | 63986 | 33424 | 64401215 |
Chest pain | 51.14 | 13.80 | 98 | 63995 | 235882 | 64198757 |
Transaminases increased | 51.09 | 13.80 | 127 | 63966 | 44467 | 64390172 |
Myalgia | 50.30 | 13.80 | 50 | 64043 | 158567 | 64276072 |
Cough | 49.90 | 13.80 | 145 | 63948 | 302003 | 64132636 |
Injection site erythema | 49.62 | 13.80 | 6 | 64087 | 70794 | 64363845 |
Wrong technique in product usage process | 49.47 | 13.80 | 4 | 64089 | 64970 | 64369669 |
Blood bilirubin increased | 49.03 | 13.80 | 147 | 63946 | 57406 | 64377233 |
Hypoxia | 48.74 | 13.80 | 195 | 63898 | 87954 | 64346685 |
Cross sensitivity reaction | 48.19 | 13.80 | 34 | 64059 | 3333 | 64431306 |
Stress | 48.18 | 13.80 | 3 | 64090 | 60531 | 64374108 |
Dyspnoea | 47.99 | 13.80 | 470 | 63623 | 718204 | 63716435 |
Acute hepatic failure | 47.92 | 13.80 | 90 | 64003 | 26022 | 64408617 |
Anticonvulsant drug level decreased | 47.67 | 13.80 | 27 | 64066 | 1803 | 64432836 |
Blood lactate dehydrogenase increased | 47.55 | 13.80 | 103 | 63990 | 32975 | 64401664 |
Discomfort | 47.53 | 13.80 | 11 | 64082 | 80867 | 64353772 |
Haemodynamic instability | 47.43 | 13.80 | 66 | 64027 | 14846 | 64419793 |
Contraindicated product administered | 47.30 | 13.80 | 24 | 64069 | 107805 | 64326834 |
Enterococcal sepsis | 47.29 | 13.80 | 30 | 64063 | 2464 | 64432175 |
Hepatomegaly | 46.80 | 13.80 | 70 | 64023 | 16812 | 64417827 |
Systemic lupus erythematosus | 46.73 | 13.80 | 10 | 64083 | 77602 | 64357037 |
Vision blurred | 46.20 | 13.80 | 16 | 64077 | 90300 | 64344339 |
Hypofibrinogenaemia | 45.68 | 13.80 | 26 | 64067 | 1752 | 64432887 |
Endocarditis | 45.02 | 13.80 | 51 | 64042 | 9327 | 64425312 |
Migraine | 44.70 | 13.80 | 5 | 64088 | 62672 | 64371967 |
Pneumococcal sepsis | 44.46 | 13.80 | 23 | 64070 | 1281 | 64433358 |
Leukocytosis | 43.78 | 13.80 | 108 | 63985 | 37632 | 64397007 |
Pleural effusion | 43.59 | 13.80 | 244 | 63849 | 126315 | 64308324 |
Infusion related reaction | 43.39 | 13.80 | 60 | 64033 | 164407 | 64270232 |
Anuria | 43.38 | 13.80 | 72 | 64021 | 18892 | 64415747 |
Syncope | 43.12 | 13.80 | 56 | 64037 | 157579 | 64277060 |
Cytomegalovirus infection | 42.67 | 13.80 | 106 | 63987 | 37093 | 64397546 |
Dry mouth | 42.63 | 13.80 | 5 | 64088 | 60413 | 64374226 |
Escherichia infection | 42.20 | 13.80 | 63 | 64030 | 15105 | 64419534 |
Nephropathy toxic | 42.10 | 13.80 | 68 | 64025 | 17446 | 64417193 |
Abdominal pain upper | 41.22 | 13.80 | 69 | 64024 | 174961 | 64259678 |
Dermatitis bullous | 40.83 | 13.80 | 55 | 64038 | 11999 | 64422640 |
Hospitalisation | 40.82 | 13.80 | 12 | 64081 | 75195 | 64359444 |
Dermatitis exfoliative generalised | 40.68 | 13.80 | 39 | 64054 | 5877 | 64428762 |
Death | 40.56 | 13.80 | 297 | 63796 | 482408 | 63952231 |
Heart rate decreased | 40.28 | 13.80 | 4 | 64089 | 55063 | 64379576 |
Sleep disorder | 39.61 | 13.80 | 6 | 64087 | 59703 | 64374936 |
Nosocomial infection | 39.55 | 13.80 | 27 | 64066 | 2510 | 64432129 |
Blood alkaline phosphatase increased | 39.07 | 13.80 | 134 | 63959 | 56145 | 64378494 |
Unevaluable event | 38.74 | 13.80 | 3 | 64090 | 50486 | 64384153 |
Type IV hypersensitivity reaction | 38.72 | 13.80 | 30 | 64063 | 3392 | 64431247 |
Oedema peripheral | 38.41 | 13.80 | 96 | 63997 | 210221 | 64224418 |
Coronary artery disease | 38.03 | 13.80 | 7 | 64086 | 60426 | 64374213 |
Liver disorder | 37.89 | 13.80 | 128 | 63965 | 53223 | 64381416 |
Cerebrovascular accident | 37.50 | 13.80 | 49 | 64044 | 137534 | 64297105 |
Dehydration | 37.25 | 13.80 | 102 | 63991 | 216661 | 64217978 |
Bronchitis | 37.16 | 13.80 | 32 | 64061 | 108711 | 64325928 |
Alanine aminotransferase increased | 37.12 | 13.80 | 251 | 63842 | 138780 | 64295859 |
Oliguria | 36.97 | 13.80 | 58 | 64035 | 14518 | 64420121 |
Eosinophilic pneumonia | 36.95 | 13.80 | 33 | 64060 | 4544 | 64430095 |
Vomiting | 36.90 | 13.80 | 360 | 63733 | 550757 | 63883882 |
Respiratory distress | 36.67 | 13.80 | 125 | 63968 | 52206 | 64382433 |
Mobility decreased | 36.32 | 13.80 | 20 | 64073 | 85820 | 64348819 |
Dyspnoea exertional | 36.12 | 13.80 | 14 | 64079 | 73716 | 64360923 |
Venoocclusive liver disease | 35.92 | 13.80 | 47 | 64046 | 9968 | 64424671 |
Nocardiosis | 35.80 | 13.80 | 33 | 64060 | 4734 | 64429905 |
Hyperferritinaemia | 35.79 | 13.80 | 15 | 64078 | 514 | 64434125 |
Musculoskeletal pain | 35.79 | 13.80 | 18 | 64075 | 81276 | 64353363 |
Pericarditis | 35.76 | 13.80 | 9 | 64084 | 62507 | 64372132 |
Respiratory tract infection bacterial | 35.40 | 13.80 | 17 | 64076 | 806 | 64433833 |
Blood pressure systolic increased | 35.12 | 13.80 | 4 | 64089 | 49449 | 64385190 |
Sputum increased | 35.02 | 13.80 | 29 | 64064 | 3606 | 64431033 |
Shock haemorrhagic | 34.78 | 13.80 | 61 | 64032 | 16730 | 64417909 |
CNS ventriculitis | 34.68 | 13.80 | 13 | 64080 | 330 | 64434309 |
Metabolic acidosis | 34.55 | 13.80 | 151 | 63942 | 70807 | 64363832 |
Drug hypersensitivity | 34.43 | 13.80 | 121 | 63972 | 237694 | 64196945 |
Immune effector cell-associated neurotoxicity syndrome | 34.37 | 13.80 | 25 | 64068 | 2570 | 64432069 |
Brain oedema | 34.35 | 13.80 | 71 | 64022 | 22004 | 64412635 |
Incorrect dose administered | 34.27 | 13.80 | 9 | 64084 | 60756 | 64373883 |
Gamma-glutamyltransferase increased | 34.10 | 13.80 | 116 | 63977 | 48394 | 64386245 |
Peritonitis | 33.80 | 13.80 | 76 | 64017 | 24947 | 64409692 |
Rhinorrhoea | 33.60 | 13.80 | 9 | 64084 | 59960 | 64374679 |
Enterococcus test positive | 33.45 | 13.80 | 21 | 64072 | 1694 | 64432945 |
Hyperlactacidaemia | 33.44 | 13.80 | 32 | 64061 | 4812 | 64429827 |
Influenza | 33.29 | 13.80 | 34 | 64059 | 106497 | 64328142 |
Blood cholesterol increased | 33.28 | 13.80 | 5 | 64088 | 50061 | 64384578 |
Chest discomfort | 33.05 | 13.80 | 40 | 64053 | 116066 | 64318573 |
Gastrooesophageal reflux disease | 32.89 | 13.80 | 21 | 64072 | 83122 | 64351517 |
Weissella infection | 32.80 | 13.80 | 7 | 64086 | 17 | 64434622 |
Meningitis candida | 32.75 | 13.80 | 10 | 64083 | 132 | 64434507 |
Somnolence | 32.67 | 13.80 | 99 | 63994 | 203546 | 64231093 |
Drug level increased | 32.65 | 13.80 | 91 | 64002 | 34105 | 64400534 |
Hepatosplenomegaly | 32.61 | 13.80 | 33 | 64060 | 5310 | 64429329 |
Perinephric abscess | 32.32 | 13.80 | 11 | 64082 | 209 | 64434430 |
Balance disorder | 32.11 | 13.80 | 22 | 64071 | 83904 | 64350735 |
Toxic encephalopathy | 32.05 | 13.80 | 44 | 64049 | 9771 | 64424868 |
Suicidal ideation | 32 | 13.80 | 13 | 64080 | 66529 | 64368110 |
Neutropenic sepsis | 31.79 | 13.80 | 71 | 64022 | 23201 | 64411438 |
Fungal sepsis | 31.58 | 13.80 | 20 | 64073 | 1638 | 64433001 |
Nasal congestion | 31.50 | 13.80 | 10 | 64083 | 59648 | 64374991 |
Neck pain | 31.30 | 13.80 | 11 | 64082 | 61522 | 64373117 |
Hyperamylasaemia | 31.20 | 13.80 | 16 | 64077 | 875 | 64433764 |
Hypersensitivity | 31.16 | 13.80 | 96 | 63997 | 196356 | 64238283 |
Graft versus host disease | 31.00 | 13.80 | 52 | 64041 | 13761 | 64420878 |
Tumour lysis syndrome | 30.81 | 13.80 | 63 | 64030 | 19377 | 64415262 |
Seizure | 30.52 | 13.80 | 276 | 63817 | 166616 | 64268023 |
Hepatotoxicity | 30.27 | 13.80 | 98 | 63995 | 39864 | 64394775 |
Injection site reaction | 30.25 | 13.80 | 5 | 64088 | 46659 | 64387980 |
Anaemia | 30.11 | 13.80 | 536 | 63557 | 378144 | 64056495 |
Multiple sclerosis relapse | 30.05 | 13.80 | 3 | 64090 | 41132 | 64393507 |
Dry skin | 29.98 | 13.80 | 7 | 64086 | 51154 | 64383485 |
Influenza like illness | 29.76 | 13.80 | 12 | 64081 | 61690 | 64372949 |
Constipation | 29.75 | 13.80 | 122 | 63971 | 229215 | 64205424 |
Fluid retention | 29.73 | 13.80 | 11 | 64082 | 59595 | 64375044 |
Pruritus | 29.28 | 13.80 | 186 | 63907 | 312214 | 64122425 |
Cardiac valve vegetation | 28.95 | 13.80 | 15 | 64078 | 838 | 64433801 |
Ototoxicity | 28.93 | 13.80 | 23 | 64070 | 2700 | 64431939 |
Cholangitis | 28.82 | 13.80 | 44 | 64049 | 10758 | 64423881 |
Cryptococcal meningoencephalitis | 28.81 | 13.80 | 10 | 64083 | 202 | 64434437 |
Hyperammonaemia | 28.79 | 13.80 | 42 | 64051 | 9862 | 64424777 |
Haemorrhagic pneumonia | 28.79 | 13.80 | 9 | 64084 | 129 | 64434510 |
Scedosporium infection | 28.67 | 13.80 | 17 | 64076 | 1237 | 64433402 |
Excessive eye blinking | 28.60 | 13.80 | 17 | 64076 | 1243 | 64433396 |
Megacolon | 28.48 | 13.80 | 24 | 64069 | 3058 | 64431581 |
Granulocyte count decreased | 28.40 | 13.80 | 17 | 64076 | 1259 | 64433380 |
Hypertension | 28.25 | 13.80 | 147 | 63946 | 259114 | 64175525 |
Increased bronchial secretion | 28.07 | 13.80 | 23 | 64070 | 2819 | 64431820 |
Portal fibrosis | 27.87 | 13.80 | 13 | 64080 | 577 | 64434062 |
Pneumonia pseudomonal | 27.61 | 13.80 | 29 | 64064 | 4874 | 64429765 |
Hypernatraemia | 27.51 | 13.80 | 46 | 64047 | 12143 | 64422496 |
Helicobacter infection | 27.50 | 13.80 | 3 | 64090 | 38359 | 64396280 |
Immunosuppressant drug level increased | 27.50 | 13.80 | 35 | 64058 | 7224 | 64427415 |
ADAMTS13 activity decreased | 27.43 | 13.80 | 9 | 64084 | 152 | 64434487 |
Clostridial sepsis | 27.36 | 13.80 | 14 | 64079 | 762 | 64433877 |
Neutrophil count decreased | 27.34 | 13.80 | 150 | 63943 | 77046 | 64357593 |
Vascular pseudoaneurysm thrombosis | 27.02 | 13.80 | 7 | 64086 | 48 | 64434591 |
Staphylococcal sepsis | 26.89 | 13.80 | 47 | 64046 | 12852 | 64421787 |
Burning sensation | 26.81 | 13.80 | 8 | 64085 | 49656 | 64384983 |
Paraesthesia | 26.46 | 13.80 | 59 | 64034 | 134463 | 64300176 |
Blood fibrinogen decreased | 26.31 | 13.80 | 17 | 64076 | 1441 | 64433198 |
Intentional product misuse | 26.29 | 13.80 | 20 | 64073 | 72275 | 64362364 |
Enterococcal bacteraemia | 26.28 | 13.80 | 21 | 64072 | 2484 | 64432155 |
Dermatitis exfoliative | 25.99 | 13.80 | 41 | 64052 | 10311 | 64424328 |
White blood cell count increased | 25.93 | 13.80 | 132 | 63961 | 65882 | 64368757 |
Staphylococcus test positive | 25.92 | 13.80 | 30 | 64063 | 5615 | 64429024 |
Pyelonephritis fungal | 25.90 | 13.80 | 8 | 64085 | 110 | 64434529 |
Device related infection | 25.86 | 13.80 | 78 | 64015 | 30548 | 64404091 |
Interleukin-2 receptor increased | 25.83 | 13.80 | 9 | 64084 | 184 | 64434455 |
Candida test positive | 25.77 | 13.80 | 15 | 64078 | 1055 | 64433584 |
Infective aneurysm | 25.73 | 13.80 | 14 | 64079 | 864 | 64433775 |
Respiratory paralysis | 25.65 | 13.80 | 7 | 64086 | 60 | 64434579 |
Amnesia | 25.65 | 13.80 | 8 | 64085 | 48261 | 64386378 |
Blood glucose increased | 25.63 | 13.80 | 36 | 64057 | 98037 | 64336602 |
Renal abscess | 25.30 | 13.80 | 14 | 64079 | 893 | 64433746 |
Aortoenteric fistula | 25.26 | 13.80 | 8 | 64085 | 120 | 64434519 |
Disseminated cryptococcosis | 25.20 | 13.80 | 17 | 64076 | 1550 | 64433089 |
Hypoaesthesia | 24.99 | 13.80 | 64 | 64029 | 139044 | 64295595 |
Pseudomonas test positive | 24.99 | 13.80 | 17 | 64076 | 1571 | 64433068 |
Motor neurone disease | 24.94 | 13.80 | 11 | 64082 | 428 | 64434211 |
Circulatory collapse | 24.89 | 13.80 | 82 | 64011 | 33650 | 64400989 |
Urticaria | 24.79 | 13.80 | 70 | 64023 | 147247 | 64287392 |
Stoma closure | 24.73 | 13.80 | 8 | 64085 | 129 | 64434510 |
Epidermolysis bullosa | 24.68 | 13.80 | 9 | 64084 | 211 | 64434428 |
Respiratory gas exchange disorder | 24.67 | 13.80 | 13 | 64080 | 752 | 64433887 |
Toxicity to various agents | 24.47 | 13.80 | 237 | 63856 | 363276 | 64071363 |
Aspartate aminotransferase increased | 24.45 | 13.80 | 203 | 63890 | 119585 | 64315054 |
Osteomyelitis bacterial | 24.42 | 13.80 | 11 | 64082 | 450 | 64434189 |
Gait inability | 24.42 | 13.80 | 6 | 64087 | 42362 | 64392277 |
Acute myeloid leukaemia recurrent | 24.34 | 13.80 | 21 | 64072 | 2763 | 64431876 |
Abdominal compartment syndrome | 24.18 | 13.80 | 16 | 64077 | 1412 | 64433227 |
Diabetic macroangiopathy | 24.17 | 13.80 | 8 | 64085 | 139 | 64434500 |
Hepatic cytolysis | 24.02 | 13.80 | 47 | 64046 | 14002 | 64420637 |
Emphysematous pyelonephritis | 23.95 | 13.80 | 9 | 64084 | 230 | 64434409 |
Central nervous system injury | 23.71 | 13.80 | 8 | 64085 | 148 | 64434491 |
Hepatitis cholestatic | 23.69 | 13.80 | 43 | 64050 | 12112 | 64422527 |
Gastrointestinal disorder | 23.38 | 13.80 | 33 | 64060 | 89676 | 64344963 |
Adjusted calcium decreased | 23.31 | 13.80 | 8 | 64085 | 156 | 64434483 |
Cytopenia | 23.18 | 13.80 | 49 | 64044 | 15422 | 64419217 |
Heart rate increased | 23.13 | 13.80 | 39 | 64054 | 98636 | 64336003 |
Flavobacterium infection | 23.09 | 13.80 | 7 | 64086 | 90 | 64434549 |
Cataract | 23.09 | 13.80 | 11 | 64082 | 51251 | 64383388 |
Angina pectoris | 23.03 | 13.80 | 8 | 64085 | 45073 | 64389566 |
Fusarium infection | 22.82 | 13.80 | 16 | 64077 | 1553 | 64433086 |
Aspergillus test positive | 22.74 | 13.80 | 12 | 64081 | 696 | 64433943 |
Product deposit | 22.67 | 13.80 | 10 | 64083 | 389 | 64434250 |
Haemostasis | 22.63 | 13.80 | 9 | 64084 | 269 | 64434370 |
Coagulation time prolonged | 22.53 | 13.80 | 18 | 64075 | 2128 | 64432511 |
Strongyloidiasis | 22.45 | 13.80 | 21 | 64072 | 3069 | 64431570 |
Product prescribing error | 22.37 | 13.80 | 4 | 64089 | 35265 | 64399374 |
Nephrogenic diabetes insipidus | 22.35 | 13.80 | 17 | 64076 | 1870 | 64432769 |
Hot flush | 22.28 | 13.80 | 9 | 64084 | 46226 | 64388413 |
Abscess | 22.13 | 13.80 | 55 | 64038 | 19249 | 64415390 |
Blood creatinine increased | 22.05 | 13.80 | 219 | 63874 | 135563 | 64299076 |
Injection site swelling | 21.71 | 13.80 | 7 | 64086 | 41346 | 64393293 |
Adverse drug reaction | 21.67 | 13.80 | 9 | 64084 | 45455 | 64389184 |
Deep vein thrombosis | 21.63 | 13.80 | 45 | 64048 | 105137 | 64329502 |
Antinuclear antibody negative | 21.55 | 13.80 | 5 | 64088 | 20 | 64434619 |
Dyspepsia | 21.47 | 13.80 | 29 | 64064 | 80283 | 64354356 |
Depressed mood | 21.43 | 13.80 | 7 | 64086 | 41005 | 64393634 |
Encephalitis | 21.43 | 13.80 | 42 | 64051 | 12529 | 64422110 |
Rectal haemorrhage | 21.35 | 13.80 | 18 | 64075 | 61799 | 64372840 |
Mediastinitis | 21.24 | 13.80 | 12 | 64081 | 797 | 64433842 |
Palpitations | 21.23 | 13.80 | 45 | 64048 | 104443 | 64330196 |
Pneumonia klebsiella | 21.18 | 13.80 | 23 | 64070 | 4014 | 64430625 |
Hepatic infarction | 21.17 | 13.80 | 12 | 64081 | 802 | 64433837 |
Graft versus host disease in gastrointestinal tract | 21.17 | 13.80 | 27 | 64066 | 5585 | 64429054 |
Klebsiella bacteraemia | 21.17 | 13.80 | 18 | 64075 | 2322 | 64432317 |
Septic embolus | 21.15 | 13.80 | 16 | 64077 | 1746 | 64432893 |
COVID-19 pneumonia | 21.04 | 13.80 | 49 | 64044 | 16455 | 64418184 |
Red blood cell sedimentation rate increased | 21.04 | 13.80 | 3 | 64090 | 31232 | 64403407 |
Meningitis | 20.92 | 13.80 | 33 | 64060 | 8296 | 64426343 |
SJS-TEN overlap | 20.89 | 13.80 | 10 | 64083 | 471 | 64434168 |
Cardiac disorder | 20.86 | 13.80 | 15 | 64078 | 55801 | 64378838 |
Lactic acidosis | 20.86 | 13.80 | 118 | 63975 | 61292 | 64373347 |
Aeromonas infection | 20.85 | 13.80 | 9 | 64084 | 332 | 64434307 |
Hypoproteinaemia | 20.84 | 13.80 | 21 | 64072 | 3361 | 64431278 |
Sepsis syndrome | 20.84 | 13.80 | 14 | 64079 | 1267 | 64433372 |
Acidosis | 20.71 | 13.80 | 51 | 64042 | 17744 | 64416895 |
Flatulence | 20.66 | 13.80 | 5 | 64088 | 35661 | 64398978 |
Overdose | 20.61 | 13.80 | 85 | 64008 | 159481 | 64275158 |
Road traffic accident | 20.60 | 13.80 | 3 | 64090 | 30742 | 64403897 |
Immune reconstitution inflammatory syndrome | 20.46 | 13.80 | 41 | 64052 | 12429 | 64422210 |
Osteonecrosis of jaw | 20.46 | 13.80 | 7 | 64086 | 39818 | 64394821 |
Impaired healing | 20.41 | 13.80 | 18 | 64075 | 60455 | 64374184 |
Escherichia bacteraemia | 20.39 | 13.80 | 26 | 64067 | 5377 | 64429262 |
Hydrocephalus | 20.36 | 13.80 | 31 | 64062 | 7560 | 64427079 |
Hepatitis fulminant | 20.30 | 13.80 | 28 | 64065 | 6246 | 64428393 |
Nephrolithiasis | 20.26 | 13.80 | 9 | 64084 | 43674 | 64390965 |
Disease complication | 20.19 | 13.80 | 23 | 64070 | 4232 | 64430407 |
Herpes simplex | 20.19 | 13.80 | 37 | 64056 | 10499 | 64424140 |
Splenic injury | 20.12 | 13.80 | 8 | 64085 | 239 | 64434400 |
Endotracheal intubation | 20.10 | 13.80 | 22 | 64071 | 3873 | 64430766 |
Mixed liver injury | 20.09 | 13.80 | 26 | 64067 | 5455 | 64429184 |
Noninfectious peritonitis | 20.06 | 13.80 | 8 | 64085 | 241 | 64434398 |
Adenovirus infection | 19.99 | 13.80 | 30 | 64063 | 7225 | 64427414 |
Hypokalaemia | 19.98 | 13.80 | 197 | 63896 | 121706 | 64312933 |
Lung abscess | 19.91 | 13.80 | 21 | 64072 | 3545 | 64431094 |
HIV viraemia | 19.73 | 13.80 | 6 | 64087 | 78 | 64434561 |
Extravasation blood | 19.72 | 13.80 | 9 | 64084 | 380 | 64434259 |
Venoocclusive disease | 19.69 | 13.80 | 22 | 64071 | 3963 | 64430676 |
Serum sickness-like reaction | 19.62 | 13.80 | 10 | 64083 | 540 | 64434099 |
Potentiating drug interaction | 19.57 | 13.80 | 31 | 64062 | 7821 | 64426818 |
Enterocolitis haemorrhagic | 19.50 | 13.80 | 16 | 64077 | 1964 | 64432675 |
Acanthosis | 19.35 | 13.80 | 9 | 64084 | 397 | 64434242 |
Chimerism | 19.26 | 13.80 | 8 | 64085 | 268 | 64434371 |
Serum ferritin increased | 19.16 | 13.80 | 32 | 64061 | 8436 | 64426203 |
Hepatic necrosis | 19.15 | 13.80 | 32 | 64061 | 8441 | 64426198 |
Gastroenteritis staphylococcal | 19.15 | 13.80 | 8 | 64085 | 272 | 64434367 |
Oropharyngeal pain | 19.14 | 13.80 | 37 | 64056 | 88830 | 64345809 |
Meningitis bacterial | 19.13 | 13.80 | 17 | 64076 | 2326 | 64432313 |
Hyperchloraemia | 19.12 | 13.80 | 12 | 64081 | 967 | 64433672 |
Necrotising fasciitis | 19.11 | 13.80 | 25 | 64068 | 5301 | 64429338 |
Endocarditis candida | 19.07 | 13.80 | 6 | 64087 | 88 | 64434551 |
Vulvovaginitis | 19.04 | 13.80 | 8 | 64085 | 276 | 64434363 |
Encephalitis viral | 18.90 | 13.80 | 17 | 64076 | 2363 | 64432276 |
Organising pneumonia | 18.89 | 13.80 | 33 | 64060 | 9022 | 64425617 |
Low cardiac output syndrome | 18.76 | 13.80 | 11 | 64082 | 784 | 64433855 |
Overgrowth fungal | 18.65 | 13.80 | 6 | 64087 | 95 | 64434544 |
Pulmonary alveolar haemorrhage | 18.41 | 13.80 | 34 | 64059 | 9704 | 64424935 |
Myocardial calcification | 18.31 | 13.80 | 5 | 64088 | 43 | 64434596 |
Abscess neck | 18.26 | 13.80 | 12 | 64081 | 1047 | 64433592 |
Vertigo | 18.24 | 13.80 | 19 | 64074 | 58992 | 64375647 |
Petechiae | 18.21 | 13.80 | 50 | 64043 | 18576 | 64416063 |
Acid base balance abnormal | 18.19 | 13.80 | 8 | 64085 | 309 | 64434330 |
White blood cell count decreased | 18.15 | 13.80 | 238 | 63855 | 157599 | 64277040 |
Infectious pleural effusion | 18.06 | 13.80 | 18 | 64075 | 2844 | 64431795 |
Acute graft versus host disease in intestine | 17.96 | 13.80 | 20 | 64073 | 3589 | 64431050 |
Aggression | 17.84 | 13.80 | 12 | 64081 | 46220 | 64388419 |
Faeces pale | 17.78 | 13.80 | 17 | 64076 | 2554 | 64432085 |
Lower respiratory tract infection bacterial | 17.71 | 13.80 | 10 | 64083 | 664 | 64433975 |
Cytokine storm | 17.65 | 13.80 | 11 | 64082 | 876 | 64433763 |
Enterobacter infection | 17.57 | 13.80 | 20 | 64073 | 3676 | 64430963 |
Urinary tract infection fungal | 17.56 | 13.80 | 11 | 64082 | 884 | 64433755 |
Osteoporosis | 17.52 | 13.80 | 10 | 64083 | 42070 | 64392569 |
Convulsive threshold lowered | 17.51 | 13.80 | 11 | 64082 | 888 | 64433751 |
Guillain-Barre syndrome | 17.48 | 13.80 | 29 | 64064 | 7606 | 64427033 |
Radiation fibrosis - lung | 17.46 | 13.80 | 5 | 64088 | 52 | 64434587 |
Type 2 diabetes mellitus | 17.44 | 13.80 | 6 | 64087 | 34014 | 64400625 |
Metabolic disorder | 17.30 | 13.80 | 29 | 64064 | 7668 | 64426971 |
Generalised tonic-clonic seizure | 17.29 | 13.80 | 82 | 64011 | 39775 | 64394864 |
Hypotension | 17.23 | 13.80 | 498 | 63595 | 380476 | 64054163 |
Relapsing fever | 17.22 | 13.80 | 8 | 64085 | 352 | 64434287 |
Mediastinal effusion | 17.21 | 13.80 | 5 | 64088 | 55 | 64434584 |
Hypovolaemic shock | 17.14 | 13.80 | 34 | 64059 | 10232 | 64424407 |
Hepatitis | 17.11 | 13.80 | 90 | 64003 | 45492 | 64389147 |
Mucosal disorder | 17.04 | 13.80 | 18 | 64075 | 3044 | 64431595 |
Hyperaemia | 17.02 | 13.80 | 17 | 64076 | 2692 | 64431947 |
Resuscitation | 16.98 | 13.80 | 15 | 64078 | 2036 | 64432603 |
Hyperpyrexia | 16.94 | 13.80 | 23 | 64070 | 5054 | 64429585 |
Dry eye | 16.94 | 13.80 | 4 | 64089 | 29015 | 64405624 |
Globulins decreased | 16.93 | 13.80 | 8 | 64085 | 366 | 64434273 |
Orthostatic hypotension | 16.90 | 13.80 | 13 | 64080 | 46725 | 64387914 |
Ischaemic cerebral infarction | 16.85 | 13.80 | 15 | 64078 | 2057 | 64432582 |
Vascular pseudoaneurysm | 16.74 | 13.80 | 18 | 64075 | 3106 | 64431533 |
Cognitive disorder | 16.73 | 13.80 | 18 | 64075 | 55069 | 64379570 |
Neutrophilic dermatosis | 16.68 | 13.80 | 9 | 64084 | 546 | 64434093 |
Bladder irrigation | 16.66 | 13.80 | 5 | 64088 | 62 | 64434577 |
Intestinal ischaemia | 16.64 | 13.80 | 36 | 64057 | 11513 | 64423126 |
Bacterial sepsis | 16.64 | 13.80 | 28 | 64065 | 7429 | 64427210 |
Rectal perforation | 16.59 | 13.80 | 10 | 64083 | 750 | 64433889 |
Neuralgia | 16.54 | 13.80 | 3 | 64090 | 26181 | 64408458 |
Exfoliative rash | 16.54 | 13.80 | 19 | 64074 | 3527 | 64431112 |
Alveolitis necrotising | 16.51 | 13.80 | 4 | 64089 | 20 | 64434619 |
Hyperthermia | 16.47 | 13.80 | 43 | 64050 | 15507 | 64419132 |
Acute lymphocytic leukaemia | 16.44 | 13.80 | 21 | 64072 | 4350 | 64430289 |
Serum sickness | 16.44 | 13.80 | 18 | 64075 | 3171 | 64431468 |
Herpes simplex viraemia | 16.43 | 13.80 | 7 | 64086 | 250 | 64434389 |
Morganella infection | 16.38 | 13.80 | 11 | 64082 | 995 | 64433644 |
Irritability | 16.38 | 13.80 | 8 | 64085 | 36738 | 64397901 |
Graft versus host disease in liver | 16.34 | 13.80 | 13 | 64080 | 1528 | 64433111 |
Diverticulitis | 16.33 | 13.80 | 9 | 64084 | 38609 | 64396030 |
Body temperature decreased | 16.32 | 13.80 | 3 | 64090 | 25925 | 64408714 |
Ill-defined disorder | 16.25 | 13.80 | 12 | 64081 | 44040 | 64390599 |
Septal panniculitis | 16.24 | 13.80 | 5 | 64088 | 68 | 64434571 |
Posterior reversible encephalopathy syndrome | 16.24 | 13.80 | 55 | 64038 | 22891 | 64411748 |
Blast cell count increased | 16.21 | 13.80 | 12 | 64081 | 1267 | 64433372 |
Organ failure | 16.17 | 13.80 | 19 | 64074 | 3614 | 64431025 |
Chest X-ray abnormal | 16.14 | 13.80 | 26 | 64067 | 6655 | 64427984 |
Hyperoxaluria | 16.08 | 13.80 | 7 | 64086 | 264 | 64434375 |
Hypertransaminasaemia | 16.04 | 13.80 | 27 | 64066 | 7164 | 64427475 |
Viral infection | 15.91 | 13.80 | 8 | 64085 | 36132 | 64398507 |
Decreased appetite | 15.85 | 13.80 | 191 | 63902 | 281098 | 64153541 |
Antibiotic level above therapeutic | 15.85 | 13.80 | 9 | 64084 | 604 | 64434035 |
Candida endophthalmitis | 15.84 | 13.80 | 6 | 64087 | 157 | 64434482 |
Night sweats | 15.83 | 13.80 | 8 | 64085 | 36038 | 64398601 |
Product administration error | 15.77 | 13.80 | 4 | 64089 | 27639 | 64407000 |
Ependymitis | 15.67 | 13.80 | 3 | 64090 | 3 | 64434636 |
Renal injury | 15.66 | 13.80 | 42 | 64051 | 15387 | 64419252 |
Viral haemorrhagic cystitis | 15.66 | 13.80 | 13 | 64080 | 1622 | 64433017 |
Cardiovascular insufficiency | 15.64 | 13.80 | 16 | 64077 | 2608 | 64432031 |
Abortion spontaneous | 15.63 | 13.80 | 3 | 64090 | 25140 | 64409499 |
Cholangiolitis | 15.63 | 13.80 | 4 | 64089 | 26 | 64434613 |
Sopor | 15.61 | 13.80 | 5 | 64088 | 29656 | 64404983 |
Herpes simplex hepatitis | 15.61 | 13.80 | 8 | 64085 | 437 | 64434202 |
Cytomegalovirus enterocolitis | 15.60 | 13.80 | 12 | 64081 | 1343 | 64433296 |
Adverse event | 15.58 | 13.80 | 10 | 64083 | 39479 | 64395160 |
Rash erythematous | 15.57 | 13.80 | 92 | 64001 | 48541 | 64386098 |
Depressed level of consciousness | 15.55 | 13.80 | 136 | 63957 | 81300 | 64353339 |
Medication error | 15.54 | 13.80 | 16 | 64077 | 49950 | 64384689 |
Mucosal inflammation | 15.52 | 13.80 | 111 | 63982 | 62473 | 64372166 |
Ileus paralytic | 15.43 | 13.80 | 29 | 64064 | 8386 | 64426253 |
Pollakiuria | 15.42 | 13.80 | 6 | 64087 | 31524 | 64403115 |
Splenomegaly | 15.41 | 13.80 | 46 | 64047 | 17915 | 64416724 |
Cholangitis infective | 15.37 | 13.80 | 8 | 64085 | 451 | 64434188 |
Basilar artery aneurysm | 15.37 | 13.80 | 4 | 64089 | 28 | 64434611 |
Intestinal pseudo-obstruction | 15.32 | 13.80 | 14 | 64079 | 1986 | 64432653 |
Clostridial infection | 15.31 | 13.80 | 22 | 64071 | 5097 | 64429542 |
Haemorrhagic disorder | 15.26 | 13.80 | 12 | 64081 | 1387 | 64433252 |
Bacterial infection | 15.25 | 13.80 | 57 | 64036 | 24893 | 64409746 |
Pulmonary sepsis | 15.23 | 13.80 | 17 | 64076 | 3058 | 64431581 |
Neoplasm malignant | 15.23 | 13.80 | 3 | 64090 | 24685 | 64409954 |
Cytomegalovirus test positive | 15.22 | 13.80 | 22 | 64071 | 5122 | 64429517 |
Candida pneumonia | 15.21 | 13.80 | 8 | 64085 | 461 | 64434178 |
Myasthenia gravis crisis | 15.20 | 13.80 | 10 | 64083 | 874 | 64433765 |
Pneumocystis jirovecii pneumonia | 15.16 | 13.80 | 61 | 64032 | 27573 | 64407066 |
Perforation | 15.07 | 13.80 | 11 | 64082 | 1137 | 64433502 |
Differentiation syndrome | 15 | 13.80 | 14 | 64079 | 2040 | 64432599 |
Vitamin K deficiency | 14.99 | 13.80 | 9 | 64084 | 670 | 64433969 |
Metabolic alkalosis | 14.98 | 13.80 | 19 | 64074 | 3909 | 64430730 |
Cytotoxic oedema | 14.92 | 13.80 | 7 | 64086 | 315 | 64434324 |
Cytomegalovirus viraemia | 14.75 | 13.80 | 33 | 64060 | 10795 | 64423844 |
Cytomegalovirus infection reactivation | 14.73 | 13.80 | 23 | 64070 | 5733 | 64428906 |
Thrombotic microangiopathy | 14.61 | 13.80 | 43 | 64050 | 16612 | 64418027 |
Disseminated mucormycosis | 14.61 | 13.80 | 8 | 64085 | 500 | 64434139 |
Hyperchlorhydria | 14.58 | 13.80 | 13 | 64080 | 1786 | 64432853 |
Graft versus host disease in skin | 14.57 | 13.80 | 22 | 64071 | 5325 | 64429314 |
Skin necrosis | 14.54 | 13.80 | 39 | 64054 | 14290 | 64420349 |
Speech disorder | 14.52 | 13.80 | 16 | 64077 | 48425 | 64386214 |
Colony stimulating factor therapy | 14.51 | 13.80 | 8 | 64085 | 507 | 64434132 |
Wound dehiscence | 14.38 | 13.80 | 23 | 64070 | 5851 | 64428788 |
Acute graft versus host disease in skin | 14.32 | 13.80 | 25 | 64068 | 6830 | 64427809 |
Haemolysis | 14.32 | 13.80 | 33 | 64060 | 11006 | 64423633 |
Aspartate aminotransferase | 14.31 | 13.80 | 6 | 64087 | 206 | 64434433 |
Blood culture positive | 14.28 | 13.80 | 27 | 64066 | 7841 | 64426798 |
Vesicoureteric reflux | 14.27 | 13.80 | 5 | 64088 | 104 | 64434535 |
Normocytic anaemia | 14.26 | 13.80 | 17 | 64076 | 3282 | 64431357 |
Limb injury | 14.20 | 13.80 | 3 | 64090 | 23502 | 64411137 |
Purpura non-thrombocytopenic | 14.20 | 13.80 | 6 | 64087 | 210 | 64434429 |
Injury | 14.19 | 13.80 | 21 | 64072 | 55971 | 64378668 |
Ear infection | 14.12 | 13.80 | 3 | 64090 | 23401 | 64411238 |
Arterial rupture | 14.08 | 13.80 | 9 | 64084 | 749 | 64433890 |
Leukoencephalopathy | 14.03 | 13.80 | 25 | 64068 | 6942 | 64427697 |
Vanishing bile duct syndrome | 14.03 | 13.80 | 11 | 64082 | 1266 | 64433373 |
Hypoglossal nerve paresis | 14.01 | 13.80 | 5 | 64088 | 110 | 64434529 |
Refractoriness to platelet transfusion | 13.92 | 13.80 | 5 | 64088 | 112 | 64434527 |
Brain herniation | 13.87 | 13.80 | 24 | 64069 | 6509 | 64428130 |
Anticonvulsant drug level below therapeutic | 13.87 | 13.80 | 10 | 64083 | 1014 | 64433625 |
Acne | 13.84 | 13.80 | 3 | 64090 | 23078 | 64411561 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug ineffective | 89.67 | 78.30 | 35 | 77 | 882 | 83684 |
Source | Code | Description |
---|---|---|
ATC | J01DH02 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Carbapenems |
ATC | J01DH52 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER BETA-LACTAM ANTIBACTERIALS Carbapenems |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
CHEBI has role | CHEBI:33282 | bactericides |
CHEBI has role | CHEBI:88188 | allergenic drug |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Streptococcal meningitis | indication | 4510004 | DOID:11574 |
Infection due to Pseudomonas aeruginosa | indication | 11218009 | |
Peritonitis | indication | 48661000 | |
Pneumococcal meningitis | indication | 51169003 | |
Abdominal abscess | indication | 75100008 | |
Bacterial meningitis | indication | 95883001 | DOID:9470 |
Infectious disease of abdomen | indication | 128070006 | |
Meningococcal meningitis | indication | 192644005 | |
Complicated appendicitis | indication | 418171008 | |
Peptostreptococcus Complicated Appendicitis | indication | ||
Pseudomonas Aeruginosa Complicated Appendicitis | indication | ||
E. Coli Complicated Appendicitis | indication | ||
Streptococcal Peritonitis | indication | ||
Bacteroides Peritonitis | indication | ||
Streptococcus Complicated Appendicitis | indication | ||
Klebsiella Pneumoniae Peritonitis | indication | ||
Complicated Skin and Skin Structure Infection | indication | ||
E. Coli Peritonitis | indication | ||
Peptostreptococcus Peritonitis | indication | ||
H. Influenzae Meningitis | indication | ||
Klebsiella Complicated Appendicitis | indication | ||
Bacteroides Complicated Appendicitis | indication | ||
Pyrexia of unknown origin | off-label use | 7520000 | |
Bacterial septicemia | off-label use | 10001005 | DOID:0040085 |
Inhalational anthrax | off-label use | 11389007 | |
Nocardiosis | off-label use | 29227009 | DOID:2312 |
Bacterial pneumonia | off-label use | 53084003 | DOID:874 |
Cholangitis | off-label use | 82403002 | DOID:9446 |
Gastrointestinal anthrax | off-label use | 111798006 | DOID:13386 |
Infection by Campylobacter fetus | off-label use | 111835002 | |
Sepsis of the newborn | off-label use | 206376005 | |
Sepsis syndrome | off-label use | 238150007 | |
Diverticulitis of gastrointestinal tract | off-label use | 271366000 | |
Neonatal meningitis | off-label use | 276674008 | |
Anthrax | off-label use | 409498004 | DOID:7427 |
Nosocomial pneumonia | off-label use | 425464007 | |
Melioidosis | off-label use | 428111003 | DOID:5052 |
Pneumonia due to Gram negative bacteria | off-label use | 430395005 | |
Clostridium Perfringens Empyema | off-label use | ||
Pseudomonas Respiratory Tract Infection in Cystic Fibrosis | off-label use | ||
Diabetic Foot Infection | off-label use | ||
Complicated Urinary Tract Infections | off-label use | ||
Kidney disease | contraindication | 90708001 | DOID:557 |
Seizure disorder | contraindication | 128613002 | |
Lesion of brain | contraindication | 301766008 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Pseudomembranous enterocolitis | contraindication | 397683000 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.79 | acidic |
pKa2 | 8.04 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
1GM/VIAL;1GM/VIAL | VABOMERE | REMPEX | N209776 | Aug. 29, 2017 | RX | POWDER | INTRAVENOUS | 10183034 | Aug. 8, 2031 | TREATMENT OF COMPLICATED URINARY TRACT INFECTION (CUTI) INCLUDING PYELONEPHRITIS CAUSED BY THE FOLLOWING SUSCEPTIBLE MICROORGANISMS: ESCHERICHIA COLI, KLEBSIELLA PNEUMONIA, AND ENTEROBACTER CLOACAE SPECIES COMPLEX |
1GM/VIAL;1GM/VIAL | VABOMERE | REMPEX | N209776 | Aug. 29, 2017 | RX | POWDER | INTRAVENOUS | 10561675 | Aug. 8, 2031 | TREATMENT OF COMPLICATED URINARY TRACT INFECTION (CUTI) INCLUDING PYELONEPHRITIS CAUSED BY THE FOLLOWING SUSCEPTIBLE MICROORGANISMS: ESCHERICHIA COLI, KLEBSIELLA PNEUMONIA, AND ENTEROBACTER CLOACAE SPECIES COMPLEX |
1GM/VIAL;1GM/VIAL | VABOMERE | REMPEX | N209776 | Aug. 29, 2017 | RX | POWDER | INTRAVENOUS | 11007206 | Aug. 8, 2031 | TREATMENT OF COMPLICATED URINARY TRACT INFECTIONS (CUTI) INCLUDING PYELONEPHRITIS CAUSED BY THE FOLLOWING SUSCEPTIBLE MICROORGANISMS: ESCHERICHIA COLI, KLEBSIELLA PNEUMONIA, ENTEROBACTER CLOACAE SPECIES COMPLEX WITH MEROPENEM & VABORBACTAM AS SPECIFIED |
1GM/VIAL;1GM/VIAL | VABOMERE | REMPEX | N209776 | Aug. 29, 2017 | RX | POWDER | INTRAVENOUS | 9694025 | Aug. 8, 2031 | TREATMENT OF PATIENTS 18 YEARS OF AGE AND OLDER WITH COMPLICATED URINARY TRACT INFECTIONS CAUSED BY SUSCEPTIBLE MICROORGANISMS |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
1GM/VIAL;1GM/VIAL | VABOMERE | REMPEX | N209776 | Aug. 29, 2017 | RX | POWDER | INTRAVENOUS | Aug. 29, 2022 | NEW CHEMICAL ENTITY |
1GM/VIAL;1GM/VIAL | VABOMERE | REMPEX | N209776 | Aug. 29, 2017 | RX | POWDER | INTRAVENOUS | Aug. 29, 2027 | GENERATING ANTIBIOTIC INCENTIVES NOW |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
D-alanyl-D-alanine carboxypeptidase DacB | Enzyme | INHIBITOR | DRUGBANK | CHEMBL | |||||
Penicillin-binding protein 4 | Enzyme | WOMBAT-PK | |||||||
D-ala-D-ala-carboxypeptidase; D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine carboxypeptidase family protein; Penicillin-binding protein 5 | Enzyme | WOMBAT-PK | |||||||
Penicillin-binding protein 1 | Enzyme | WOMBAT-PK | |||||||
D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine carboxypeptidase penicillin-binding protein 6 | Enzyme | WOMBAT-PK | |||||||
Streptokinase A | Enzyme | EC50 | 6.90 | WOMBAT-PK | |||||
Beta-lactamase class B VIM-2 | Unclassified | Kd | 4.92 | CHEMBL | |||||
Beta-lactamase NDM-1 | Enzyme | Kd | 4.96 | CHEMBL | |||||
Penicillin-binding protein 2 | Enzyme | WOMBAT-PK | |||||||
Beta-lactamase | Enzyme | Kd | 6.07 | CHEMBL |
ID | Source |
---|---|
4021008 | VUID |
N0000148477 | NUI |
D02222 | KEGG_DRUG |
4021008 | VANDF |
C0066005 | UMLSCUI |
CHEBI:43968 | CHEBI |
MEM | PDB_CHEM_ID |
CHEMBL127 | ChEMBL_ID |
DB00760 | DRUGBANK_ID |
D000077731 | MESH_DESCRIPTOR_UI |
441130 | PUBCHEM_CID |
10829 | IUPHAR_LIGAND_ID |
FV9J3JU8B1 | UNII |
29561 | RXNORM |
173661 | MMSL |
5055 | MMSL |
6047 | MMSL |
d04027 | MMSL |
005166 | NDDF |
387540000 | SNOMEDCT_US |
725669004 | SNOMEDCT_US |
96062004 | SNOMEDCT_US |
119478-56-7 | SECONDARY_CAS_RN |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
MERREM IV | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0313 | INJECTION | 500 mg | INTRAVENOUS | NDA | 30 sections |
MERREM IV | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0069-0314 | INJECTION | 1 g | INTRAVENOUS | NDA | 30 sections |
Meropenem and Sodium Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3183 | INJECTION, SOLUTION | 500 mg | INTRAVENOUS | NDA | 26 sections |
Meropenem and Sodium Chloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0264-3185 | INJECTION, SOLUTION | 1 g | INTRAVENOUS | NDA | 26 sections |
Meropenem | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1390 | INJECTION, POWDER, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 27 sections |
Meropenem | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1391 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 27 sections |
MEROPENEM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3000 | INJECTION | 500 mg | INTRAVENOUS | ANDA | 30 sections |
MEROPENEM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3000 | INJECTION | 500 mg | INTRAVENOUS | ANDA | 30 sections |
MEROPENEM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3098 | INJECTION | 1 g | INTRAVENOUS | ANDA | 30 sections |
MEROPENEM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3098 | INJECTION | 1 g | INTRAVENOUS | ANDA | 30 sections |
Meropenem | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-145 | INJECTION, POWDER, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 28 sections |
Meropenem | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-146 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 28 sections |
Meropenem | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-400 | INJECTION, POWDER, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 28 sections |
Meropenem | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44567-401 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 28 sections |
MEROPENEM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44647-032 | INJECTION | 500 mg | INTRAVENOUS | ANDA | 30 sections |
MEROPENEM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 44647-033 | INJECTION | 1 g | INTRAVENOUS | ANDA | 30 sections |
Meropenem | Human Prescription Drug Label | 1 | 55150-207 | INJECTION, POWDER, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 26 sections |
Meropenem | Human Prescription Drug Label | 1 | 55150-208 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 26 sections |
Meropenem | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-507 | INJECTION, POWDER, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 28 sections |
Meropenem | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-507 | INJECTION, POWDER, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 28 sections |
Meropenem | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-507 | INJECTION, POWDER, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 28 sections |
Meropenem | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-508 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 28 sections |
Meropenem | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-508 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 28 sections |
Meropenem | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-508 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 28 sections |
Meropenem | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68001-323 | INJECTION, POWDER, FOR SOLUTION | 500 mg | INTRAVENOUS | ANDA | 27 sections |
Meropenem | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68001-324 | INJECTION, POWDER, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 27 sections |
MEROPENEM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68001-446 | INJECTION | 500 mg | INTRAVENOUS | ANDA | 29 sections |
MEROPENEM | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68001-447 | INJECTION | 1 g | INTRAVENOUS | ANDA | 29 sections |
Meropenem | Human Prescription Drug Label | 1 | 68083-146 | INJECTION | 500 mg | INTRAVENOUS | ANDA | 27 sections |
Meropenem | Human Prescription Drug Label | 1 | 68083-147 | INJECTION | 1 g | INTRAVENOUS | ANDA | 27 sections |