mepenzolate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 1689 | 25990-43-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
anticholinergic, antispasmodic agent; RN given refers to parent cpd; structure
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.10 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Nov. 14, 1956 | FDA | SANOFI AVENTIS US |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A03AB12 | ALIMENTARY TRACT AND METABOLISM DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS Synthetic anticholinergics, quaternary ammonium compounds |
| FDA MoA | N0000175370 | Cholinergic Antagonists |
| FDA EPC | N0000175574 | Anticholinergic |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Peptic ulcer | indication | 13200003 | DOID:750 |
| Gastric ulcer | indication | 397825006 | DOID:10808 |
| Irritable bowel syndrome | off-label use | 10743008 | DOID:9778 |
| Tachyarrhythmia | contraindication | 6285003 | |
| Urinary tract obstruction | contraindication | 7163005 | DOID:5200 |
| Disorder of autonomic nervous system | contraindication | 15241006 | |
| Glaucoma | contraindication | 23986001 | DOID:1686 |
| Toxic megacolon | contraindication | 28536002 | DOID:1770 |
| Atony of colon | contraindication | 29479008 | |
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Chronic heart failure | contraindication | 48447003 | |
| Paralytic ileus | contraindication | 55525008 | DOID:8442 |
| Peptic reflux disease | contraindication | 57643001 | |
| Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Myasthenia gravis | contraindication | 91637004 | DOID:437 |
| Gastrointestinal obstruction | contraindication | 126765001 | |
| Bleeding | contraindication | 131148009 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Benign prostatic hyperplasia | contraindication | 266569009 | |
| Disorder of coronary artery | contraindication | 414024009 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.68 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M1 | GPCR | ANTAGONIST | CHEMBL | CHEMBL | |||||
| Muscarinic acetylcholine receptor M3 | GPCR | ANTAGONIST | Ki | 8.59 | CHEMBL | CHEMBL | |||
| Muscarinic acetylcholine receptor M2 | GPCR | Ki | 9.17 | CHEMBL | |||||
| Solute carrier family 22 member 1 | Transporter | IC50 | 4.19 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019812 | VUID |
| N0000147901 | NUI |
| D00720 | KEGG_DRUG |
| 76-90-4 | SECONDARY_CAS_RN |
| 4018609 | VANDF |
| 4019812 | VANDF |
| C0360172 | UMLSCUI |
| CHEBI:6752 | CHEBI |
| CHEMBL1724 | ChEMBL_ID |
| CHEMBL524004 | ChEMBL_ID |
| DB04843 | DRUGBANK_ID |
| C005101 | MESH_SUPPLEMENTAL_RECORD_UI |
| 4057 | PUBCHEM_CID |
| ONW3LB39P7 | UNII |
| 107770 | RXNORM |
| 5045 | MMSL |
| d00995 | MMSL |
| 001746 | NDDF |
| 004701 | NDDF |
| 372834001 | SNOMEDCT_US |
| 60289002 | SNOMEDCT_US |
| 74022005 | SNOMEDCT_US |
| 889 | INN_ID |
Pharmaceutical products:
None