Stem definition | Drug id | CAS RN |
---|---|---|
1678 | 148-82-3 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 0.10 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 12 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.33 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 71 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.48 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 7 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.14 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Jan. 17, 1964 | FDA | GLAXOSMITHKLINE |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Acute graft versus host disease | 524.33 | 17.77 | 152 | 22132 | 4165 | 53322617 |
Mucosal inflammation | 523.73 | 17.77 | 285 | 21999 | 42499 | 53284283 |
Graft versus host disease | 445.46 | 17.77 | 151 | 22133 | 6971 | 53319811 |
Plasma cell myeloma | 392.55 | 17.77 | 246 | 22038 | 47628 | 53279154 |
Myelodysplastic syndrome | 390.48 | 17.77 | 173 | 22111 | 16487 | 53310295 |
Adenovirus infection | 383.46 | 17.77 | 112 | 22172 | 3150 | 53323632 |
Venoocclusive liver disease | 370.81 | 17.77 | 118 | 22166 | 4454 | 53322328 |
Febrile neutropenia | 351.74 | 17.77 | 315 | 21969 | 104621 | 53222161 |
Thrombotic microangiopathy | 337.15 | 17.77 | 132 | 22152 | 9205 | 53317577 |
Acute graft versus host disease in skin | 292.22 | 17.77 | 91 | 22193 | 3195 | 53323587 |
Cytomegalovirus infection | 280.79 | 17.77 | 145 | 22139 | 19394 | 53307388 |
Chronic graft versus host disease | 272.88 | 17.77 | 86 | 22198 | 3142 | 53323640 |
Neutropenia | 250.74 | 17.77 | 320 | 21964 | 158865 | 53167917 |
Cytomegalovirus infection reactivation | 241.19 | 17.77 | 74 | 22210 | 2470 | 53324312 |
Thrombocytopenia | 216.97 | 17.77 | 278 | 22006 | 138449 | 53188333 |
Acute graft versus host disease in intestine | 200.67 | 17.77 | 59 | 22225 | 1697 | 53325085 |
Acute myeloid leukaemia | 196.44 | 17.77 | 109 | 22175 | 16823 | 53309959 |
Venoocclusive disease | 187.30 | 17.77 | 58 | 22226 | 1997 | 53324785 |
Pancytopenia | 184.33 | 17.77 | 208 | 22076 | 90720 | 53236062 |
Osteonecrosis | 172.27 | 17.77 | 118 | 22166 | 26457 | 53300325 |
Graft versus host disease in skin | 168.78 | 17.77 | 57 | 22227 | 2596 | 53324186 |
Post transplant lymphoproliferative disorder | 162.00 | 17.77 | 63 | 22221 | 4308 | 53322474 |
BK virus infection | 159.52 | 17.77 | 57 | 22227 | 3075 | 53323707 |
Product use in unapproved indication | 152.30 | 17.77 | 210 | 22074 | 112079 | 53214703 |
Cystitis haemorrhagic | 150.27 | 17.77 | 58 | 22226 | 3886 | 53322896 |
Sepsis | 141.81 | 17.77 | 234 | 22050 | 146195 | 53180587 |
Graft versus host disease in gastrointestinal tract | 136.05 | 17.77 | 50 | 22234 | 2924 | 53323858 |
Epstein-Barr virus infection | 132.97 | 17.77 | 64 | 22220 | 7354 | 53319428 |
Viraemia | 124.56 | 17.77 | 37 | 22247 | 1103 | 53325679 |
Stem cell transplant | 122.74 | 17.77 | 41 | 22243 | 1804 | 53324978 |
Bone marrow failure | 115.93 | 17.77 | 98 | 22186 | 30017 | 53296765 |
Haemophagocytic lymphohistiocytosis | 114.74 | 17.77 | 62 | 22222 | 9075 | 53317707 |
Headache | 112.63 | 17.77 | 42 | 22242 | 536779 | 52790003 |
Cytomegalovirus viraemia | 111.01 | 17.77 | 50 | 22234 | 4941 | 53321841 |
Posterior reversible encephalopathy syndrome | 98.23 | 17.77 | 69 | 22215 | 16091 | 53310691 |
Malignant transformation | 98.17 | 17.77 | 24 | 22260 | 332 | 53326450 |
Retinal pigment epitheliopathy | 97.37 | 17.77 | 22 | 22262 | 211 | 53326571 |
Human herpesvirus 6 infection | 95.65 | 17.77 | 37 | 22247 | 2493 | 53324289 |
Mucosal disorder | 95.16 | 17.77 | 35 | 22249 | 2051 | 53324731 |
Arthralgia | 92.85 | 17.77 | 34 | 22250 | 439749 | 52887033 |
Plasma cell myeloma recurrent | 92.56 | 17.77 | 37 | 22247 | 2720 | 53324062 |
Engraftment syndrome | 90.39 | 17.77 | 23 | 22261 | 378 | 53326404 |
Epstein-Barr viraemia | 90.38 | 17.77 | 27 | 22257 | 821 | 53325961 |
Off label use | 87.54 | 17.77 | 409 | 21875 | 471803 | 52854979 |
Engraft failure | 86.10 | 17.77 | 22 | 22262 | 368 | 53326414 |
Prothrombin level increased | 84.98 | 17.77 | 20 | 22264 | 233 | 53326549 |
Drug hypersensitivity | 84.70 | 17.77 | 7 | 22277 | 265235 | 53061547 |
Pyrexia | 82.73 | 17.77 | 360 | 21924 | 402833 | 52923949 |
Chronic graft versus host disease in skin | 81.69 | 17.77 | 24 | 22260 | 688 | 53326094 |
Second primary malignancy | 80.20 | 17.77 | 45 | 22239 | 7087 | 53319695 |
Vitreous haemorrhage | 79.63 | 17.77 | 30 | 22254 | 1880 | 53324902 |
Pain | 77.74 | 17.77 | 79 | 22205 | 588319 | 52738463 |
Joint swelling | 75.44 | 17.77 | 6 | 22278 | 234632 | 53092150 |
Osteonecrosis of jaw | 75.37 | 17.77 | 84 | 22200 | 36062 | 53290720 |
Premature menopause | 74.45 | 17.77 | 23 | 22261 | 785 | 53325997 |
Malaise | 71.54 | 17.77 | 30 | 22254 | 357587 | 52969195 |
Acute myeloid leukaemia recurrent | 71.29 | 17.77 | 26 | 22258 | 1487 | 53325295 |
Chorioretinal atrophy | 71.10 | 17.77 | 14 | 22270 | 63 | 53326719 |
Varicella zoster virus infection | 71.08 | 17.77 | 30 | 22254 | 2533 | 53324249 |
Acute graft versus host disease in liver | 69.60 | 17.77 | 21 | 22263 | 661 | 53326121 |
Encephalitis viral | 68.76 | 17.77 | 26 | 22258 | 1646 | 53325136 |
Viral haemorrhagic cystitis | 67.58 | 17.77 | 21 | 22263 | 731 | 53326051 |
Fatigue | 67.53 | 17.77 | 127 | 22157 | 730379 | 52596403 |
Iris atrophy | 67.26 | 17.77 | 13 | 22271 | 52 | 53326730 |
Neuropathy peripheral | 65.90 | 17.77 | 138 | 22146 | 103049 | 53223733 |
Aplasia | 65.67 | 17.77 | 33 | 22251 | 4159 | 53322623 |
Abdominal discomfort | 64.93 | 17.77 | 8 | 22276 | 221054 | 53105728 |
Cytomegalovirus test positive | 63.99 | 17.77 | 29 | 22255 | 2906 | 53323876 |
Multiple organ dysfunction syndrome | 63.48 | 17.77 | 96 | 22188 | 55581 | 53271201 |
Progressive multifocal leukoencephalopathy | 62.80 | 17.77 | 47 | 22237 | 12082 | 53314700 |
Epstein-Barr virus infection reactivation | 62.76 | 17.77 | 18 | 22266 | 473 | 53326309 |
Eye excision | 62.70 | 17.77 | 12 | 22272 | 45 | 53326737 |
Acute lymphocytic leukaemia | 61.49 | 17.77 | 28 | 22256 | 2837 | 53323945 |
Fall | 59.90 | 17.77 | 38 | 22246 | 358402 | 52968380 |
Pneumonia fungal | 59.58 | 17.77 | 32 | 22252 | 4624 | 53322158 |
Septic shock | 56.84 | 17.77 | 97 | 22187 | 62132 | 53264650 |
Refractory cytopenia with multilineage dysplasia | 56.42 | 17.77 | 13 | 22271 | 137 | 53326645 |
Chronic myelomonocytic leukaemia | 55.00 | 17.77 | 15 | 22269 | 326 | 53326456 |
Dizziness | 54.97 | 17.77 | 45 | 22239 | 372214 | 52954568 |
Polyneuropathy | 54.93 | 17.77 | 45 | 22239 | 13188 | 53313594 |
Hepatitis B reactivation | 54.01 | 17.77 | 23 | 22261 | 1985 | 53324797 |
Nasopharyngitis | 53.99 | 17.77 | 8 | 22276 | 192287 | 53134495 |
Stomatitis | 53.28 | 17.77 | 123 | 22161 | 98035 | 53228747 |
Tooth extraction | 52.56 | 17.77 | 40 | 22244 | 10542 | 53316240 |
Choroidal infarction | 52.01 | 17.77 | 11 | 22273 | 75 | 53326707 |
Febrile bone marrow aplasia | 51.54 | 17.77 | 34 | 22250 | 7155 | 53319627 |
Peripheral swelling | 50.57 | 17.77 | 12 | 22272 | 206096 | 53120686 |
Bronchopulmonary aspergillosis | 50.34 | 17.77 | 36 | 22248 | 8629 | 53318153 |
Renal failure | 50.15 | 17.77 | 135 | 22149 | 118317 | 53208465 |
Disturbance in social behaviour | 49.53 | 17.77 | 24 | 22260 | 2797 | 53323985 |
Pericardial effusion | 49.47 | 17.77 | 59 | 22225 | 27219 | 53299563 |
Bone debridement | 49.25 | 17.77 | 14 | 22270 | 356 | 53326426 |
Plasmacytoma | 48.48 | 17.77 | 23 | 22261 | 2558 | 53324224 |
Cytomegalovirus chorioretinitis | 48.07 | 17.77 | 20 | 22264 | 1629 | 53325153 |
Alopecia | 47.96 | 17.77 | 19 | 22265 | 234564 | 53092218 |
Infection | 47.50 | 17.77 | 169 | 22115 | 172036 | 53154746 |
Enterococcal infection | 47.47 | 17.77 | 33 | 22251 | 7565 | 53319217 |
Bacterial sepsis | 47.28 | 17.77 | 26 | 22258 | 3936 | 53322846 |
Hypogonadism female | 46.16 | 17.77 | 8 | 22276 | 14 | 53326768 |
Eyelid rash | 45.66 | 17.77 | 10 | 22274 | 82 | 53326700 |
Nasal abscess | 45.48 | 17.77 | 11 | 22273 | 145 | 53326637 |
Enterococcal sepsis | 44.35 | 17.77 | 18 | 22266 | 1376 | 53325406 |
Mucocutaneous ulceration | 44.29 | 17.77 | 11 | 22273 | 163 | 53326619 |
Epstein-Barr virus associated lymphoproliferative disorder | 44.28 | 17.77 | 19 | 22265 | 1671 | 53325111 |
Haematotoxicity | 44.03 | 17.77 | 32 | 22252 | 7865 | 53318917 |
Cardiac failure | 43.78 | 17.77 | 105 | 22179 | 85739 | 53241043 |
Gastrointestinal fungal infection | 43.78 | 17.77 | 12 | 22272 | 266 | 53326516 |
Product dose omission issue | 43.51 | 17.77 | 13 | 22271 | 191607 | 53135175 |
Transplant failure | 42.82 | 17.77 | 18 | 22266 | 1504 | 53325278 |
Pruritus | 42.75 | 17.77 | 36 | 22248 | 293796 | 53032986 |
Respiratory syncytial virus infection | 42.63 | 17.77 | 27 | 22257 | 5301 | 53321481 |
Extraocular muscle disorder | 42.29 | 17.77 | 10 | 22274 | 119 | 53326663 |
Feeling abnormal | 41.99 | 17.77 | 4 | 22280 | 135297 | 53191485 |
Eyelid oedema | 41.94 | 17.77 | 35 | 22249 | 10519 | 53316263 |
Arthropathy | 41.80 | 17.77 | 5 | 22279 | 141448 | 53185334 |
Anxiety | 41.76 | 17.77 | 15 | 22269 | 196689 | 53130093 |
Pain in extremity | 41.37 | 17.77 | 35 | 22249 | 285015 | 53041767 |
Tonsillar haemorrhage | 40.78 | 17.77 | 11 | 22273 | 229 | 53326553 |
Idiopathic pneumonia syndrome | 40.32 | 17.77 | 12 | 22272 | 360 | 53326422 |
JC virus infection | 39.57 | 17.77 | 18 | 22266 | 1819 | 53324963 |
Chest pain | 39.53 | 17.77 | 15 | 22269 | 190170 | 53136612 |
Plasma cell leukaemia | 39.50 | 17.77 | 16 | 22268 | 1217 | 53325565 |
Morganella infection | 38.93 | 17.77 | 13 | 22271 | 571 | 53326211 |
Dyspnoea | 38.92 | 17.77 | 121 | 22163 | 586111 | 52740671 |
Bone disorder | 37.93 | 17.77 | 45 | 22239 | 20638 | 53306144 |
Cytopenia | 37.67 | 17.77 | 31 | 22253 | 9139 | 53317643 |
Sinus polyp | 37.45 | 17.77 | 11 | 22273 | 315 | 53326467 |
Cardiac failure acute | 35.82 | 17.77 | 30 | 22254 | 9062 | 53317720 |
Disease progression | 35.21 | 17.77 | 108 | 22176 | 101812 | 53224970 |
Heterochromia iridis | 34.81 | 17.77 | 6 | 22278 | 10 | 53326772 |
Infusion related reaction | 34.64 | 17.77 | 11 | 22273 | 155946 | 53170836 |
Condition aggravated | 34.63 | 17.77 | 44 | 22240 | 297090 | 53029692 |
Cardiomyopathy | 34.39 | 17.77 | 39 | 22245 | 17049 | 53309733 |
Endocarditis bacterial | 33.85 | 17.77 | 12 | 22272 | 632 | 53326150 |
Pneumonia cytomegaloviral | 33.73 | 17.77 | 17 | 22267 | 2155 | 53324627 |
Urticaria | 33.14 | 17.77 | 8 | 22276 | 135877 | 53190905 |
Growth failure | 32.98 | 17.77 | 10 | 22274 | 320 | 53326462 |
Blood pressure increased | 32.86 | 17.77 | 9 | 22275 | 140470 | 53186312 |
Leukaemia | 32.73 | 17.77 | 20 | 22264 | 3686 | 53323096 |
Gastrointestinal mucosal disorder | 31.86 | 17.77 | 12 | 22272 | 751 | 53326031 |
Asthma | 31.83 | 17.77 | 4 | 22280 | 108968 | 53217814 |
Retinoblastoma | 31.82 | 17.77 | 8 | 22276 | 125 | 53326657 |
Encephalopathy | 31.80 | 17.77 | 56 | 22228 | 36752 | 53290030 |
Pulmonary haemorrhage | 31.80 | 17.77 | 25 | 22259 | 6908 | 53319874 |
Follicular thyroid cancer | 31.79 | 17.77 | 7 | 22277 | 59 | 53326723 |
Neuralgic amyotrophy | 31.67 | 17.77 | 6 | 22278 | 21 | 53326761 |
Overdose | 31.36 | 17.77 | 4 | 22280 | 107732 | 53219050 |
Sequestrectomy | 31.36 | 17.77 | 13 | 22271 | 1049 | 53325733 |
Leukopenia | 31.34 | 17.77 | 84 | 22200 | 73379 | 53253403 |
Depression | 31.08 | 17.77 | 19 | 22265 | 183033 | 53143749 |
Herpes zoster | 30.94 | 17.77 | 84 | 22200 | 73935 | 53252847 |
Bacteraemia | 30.47 | 17.77 | 35 | 22249 | 15514 | 53311268 |
Ovarian failure | 30.39 | 17.77 | 13 | 22271 | 1134 | 53325648 |
Oesophagitis | 30.39 | 17.77 | 34 | 22250 | 14643 | 53312139 |
Chronic graft versus host disease in intestine | 30.19 | 17.77 | 7 | 22277 | 76 | 53326706 |
Disease recurrence | 29.57 | 17.77 | 40 | 22244 | 20906 | 53305876 |
Adenoviral haemorrhagic cystitis | 29.46 | 17.77 | 8 | 22276 | 171 | 53326611 |
Eyelid ptosis | 28.88 | 17.77 | 23 | 22261 | 6474 | 53320308 |
Bronchospasm | 28.62 | 17.77 | 35 | 22249 | 16563 | 53310219 |
Infection reactivation | 28.44 | 17.77 | 12 | 22272 | 1012 | 53325770 |
Drug interaction | 28.21 | 17.77 | 30 | 22254 | 219299 | 53107483 |
Plastic surgery | 28.11 | 17.77 | 7 | 22277 | 105 | 53326677 |
Contusion | 28.04 | 17.77 | 6 | 22278 | 110726 | 53216056 |
Hypersensitivity | 28.01 | 17.77 | 28 | 22256 | 210637 | 53116145 |
Wound | 27.64 | 17.77 | 3 | 22281 | 91554 | 53235228 |
Mucosal erosion | 27.57 | 17.77 | 13 | 22271 | 1426 | 53325356 |
Peritonitis viral | 27.52 | 17.77 | 6 | 22278 | 48 | 53326734 |
Loss of consciousness | 27.31 | 17.77 | 7 | 22277 | 114205 | 53212577 |
Osteolysis | 27.11 | 17.77 | 16 | 22268 | 2769 | 53324013 |
Escherichia bacteraemia | 27.06 | 17.77 | 17 | 22267 | 3291 | 53323491 |
Enophthalmos | 26.90 | 17.77 | 6 | 22278 | 54 | 53326728 |
Lymphopenia | 26.62 | 17.77 | 34 | 22250 | 16809 | 53309973 |
Endothelial dysfunction | 26.56 | 17.77 | 7 | 22277 | 133 | 53326649 |
Paranoia | 26.33 | 17.77 | 28 | 22256 | 11396 | 53315386 |
Acute respiratory distress syndrome | 26.25 | 17.77 | 40 | 22244 | 23292 | 53303490 |
Hypogammaglobulinaemia | 26.00 | 17.77 | 21 | 22263 | 6029 | 53320753 |
Acute promyelocytic leukaemia | 25.98 | 17.77 | 11 | 22273 | 936 | 53325846 |
Gastrointestinal toxicity | 25.87 | 17.77 | 19 | 22265 | 4743 | 53322039 |
Complications of bone marrow transplant | 25.78 | 17.77 | 9 | 22275 | 453 | 53326329 |
Nausea | 25.69 | 17.77 | 198 | 22086 | 755893 | 52570889 |
Blood stem cell transplant failure | 25.54 | 17.77 | 7 | 22277 | 155 | 53326627 |
Retinal detachment | 25.34 | 17.77 | 20 | 22264 | 5555 | 53321227 |
Weight increased | 25.18 | 17.77 | 29 | 22255 | 204538 | 53122244 |
Gait disturbance | 24.92 | 17.77 | 18 | 22266 | 158824 | 53167958 |
Acute kidney injury | 24.70 | 17.77 | 186 | 22098 | 253682 | 53073100 |
Actinomycosis | 24.65 | 17.77 | 11 | 22273 | 1063 | 53325719 |
Hepatitis B | 24.54 | 17.77 | 17 | 22267 | 3875 | 53322907 |
Jaw operation | 24.05 | 17.77 | 10 | 22274 | 813 | 53325969 |
Chest discomfort | 24.05 | 17.77 | 6 | 22278 | 99689 | 53227093 |
Myocardial infarction | 23.93 | 17.77 | 6 | 22278 | 99348 | 53227434 |
Toxicity to various agents | 23.73 | 17.77 | 165 | 22119 | 219433 | 53107349 |
Myelosuppression | 23.67 | 17.77 | 28 | 22256 | 12800 | 53313982 |
Weight decreased | 23.23 | 17.77 | 39 | 22245 | 234909 | 53091873 |
Iris neovascularisation | 23.16 | 17.77 | 5 | 22279 | 38 | 53326744 |
Transplantation complication | 22.96 | 17.77 | 6 | 22278 | 110 | 53326672 |
Purulent discharge | 22.83 | 17.77 | 18 | 22266 | 4992 | 53321790 |
Bone sequestrum | 22.73 | 17.77 | 12 | 22272 | 1674 | 53325108 |
Insomnia | 22.51 | 17.77 | 27 | 22257 | 187045 | 53139737 |
Fungaemia | 22.49 | 17.77 | 13 | 22271 | 2164 | 53324618 |
Klebsiella bacteraemia | 22.46 | 17.77 | 11 | 22273 | 1311 | 53325471 |
Osteomyelitis | 22.41 | 17.77 | 38 | 22246 | 24197 | 53302585 |
Platelet count decreased | 22.39 | 17.77 | 97 | 22187 | 108002 | 53218780 |
Aspergillus infection | 22.10 | 17.77 | 21 | 22263 | 7475 | 53319307 |
Pulmonary veno-occlusive disease | 21.91 | 17.77 | 10 | 22274 | 1018 | 53325764 |
Urethritis | 21.69 | 17.77 | 7 | 22277 | 276 | 53326506 |
Retinal depigmentation | 21.66 | 17.77 | 7 | 22277 | 277 | 53326505 |
Arthritis | 21.55 | 17.77 | 5 | 22279 | 87293 | 53239489 |
Respiratory failure | 21.43 | 17.77 | 91 | 22193 | 100421 | 53226361 |
Hyperhidrosis | 21.18 | 17.77 | 7 | 22277 | 96786 | 53229996 |
Acinetobacter infection | 21.13 | 17.77 | 11 | 22273 | 1492 | 53325290 |
Myalgia | 21.10 | 17.77 | 15 | 22269 | 133476 | 53193306 |
Encephalitis | 21.07 | 17.77 | 21 | 22263 | 7923 | 53318859 |
Graft versus host disease in liver | 21.07 | 17.77 | 8 | 22276 | 512 | 53326270 |
Cerebral vasoconstriction | 21.07 | 17.77 | 10 | 22274 | 1113 | 53325669 |
Aspartate aminotransferase increased | 21.05 | 17.77 | 80 | 22204 | 83949 | 53242833 |
Culture stool positive | 20.91 | 17.77 | 7 | 22277 | 310 | 53326472 |
Oesophageal squamous cell carcinoma stage IV | 20.90 | 17.77 | 4 | 22280 | 15 | 53326767 |
Memory impairment | 20.64 | 17.77 | 5 | 22279 | 84752 | 53242030 |
Drug intolerance | 20.41 | 17.77 | 34 | 22250 | 205459 | 53121323 |
Pityriasis | 20.34 | 17.77 | 3 | 22281 | 0 | 53326782 |
Hepatic enzyme increased | 20.19 | 17.77 | 14 | 22270 | 126181 | 53200601 |
Oral disorder | 20.02 | 17.77 | 21 | 22263 | 8414 | 53318368 |
Abdominal pain upper | 20.00 | 17.77 | 24 | 22260 | 166267 | 53160515 |
Osteitis | 19.99 | 17.77 | 14 | 22270 | 3245 | 53323537 |
Hepatic vein occlusion | 19.95 | 17.77 | 5 | 22279 | 77 | 53326705 |
Pseudomonal sepsis | 19.86 | 17.77 | 12 | 22272 | 2167 | 53324615 |
Chronic myeloid leukaemia | 19.85 | 17.77 | 13 | 22271 | 2701 | 53324081 |
Graft versus host disease in lung | 19.77 | 17.77 | 7 | 22277 | 367 | 53326415 |
Palpitations | 19.75 | 17.77 | 9 | 22275 | 102339 | 53224443 |
Oral fungal infection | 19.72 | 17.77 | 13 | 22271 | 2731 | 53324051 |
Swelling | 19.56 | 17.77 | 31 | 22253 | 191074 | 53135708 |
Acute lymphocytic leukaemia recurrent | 19.52 | 17.77 | 12 | 22272 | 2236 | 53324546 |
Schistocytosis | 19.50 | 17.77 | 4 | 22280 | 23 | 53326759 |
Refractory cancer | 19.44 | 17.77 | 5 | 22279 | 86 | 53326696 |
Intraductal proliferative breast lesion | 19.42 | 17.77 | 13 | 22271 | 2801 | 53323981 |
JC virus CSF test positive | 19.21 | 17.77 | 4 | 22280 | 25 | 53326757 |
Diarrhoea | 18.88 | 17.77 | 366 | 21918 | 625180 | 52701602 |
Leukaemia recurrent | 18.80 | 17.77 | 10 | 22274 | 1417 | 53325365 |
Pneumonia respiratory syncytial viral | 18.65 | 17.77 | 8 | 22276 | 703 | 53326079 |
Refractory anaemia with an excess of blasts | 18.62 | 17.77 | 7 | 22277 | 436 | 53326346 |
Bronchiolitis obliterans syndrome | 18.54 | 17.77 | 5 | 22279 | 104 | 53326678 |
Blister | 18.49 | 17.77 | 5 | 22279 | 78748 | 53248034 |
Pneumococcal infection | 18.39 | 17.77 | 7 | 22277 | 451 | 53326331 |
IIIrd nerve disorder | 18.27 | 17.77 | 3 | 22281 | 3 | 53326779 |
Chronic graft versus host disease in liver | 18.05 | 17.77 | 6 | 22278 | 260 | 53326522 |
Type III immune complex mediated reaction | 18.05 | 17.77 | 6 | 22278 | 260 | 53326522 |
Heart rate increased | 17.93 | 17.77 | 6 | 22278 | 82309 | 53244473 |
Choroidal dystrophy | 17.80 | 17.77 | 3 | 22281 | 4 | 53326778 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Venoocclusive liver disease | 607.52 | 17.12 | 231 | 27670 | 7134 | 32478491 |
Acute graft versus host disease | 599.20 | 17.12 | 220 | 27681 | 6150 | 32479475 |
Mucosal inflammation | 516.19 | 17.12 | 334 | 27567 | 33100 | 32452525 |
Myelodysplastic syndrome | 497.40 | 17.12 | 272 | 27629 | 19766 | 32465859 |
Plasma cell myeloma | 426.00 | 17.12 | 370 | 27531 | 57244 | 32428381 |
Acute myeloid leukaemia | 423.26 | 17.12 | 241 | 27660 | 18933 | 32466692 |
Febrile neutropenia | 358.02 | 17.12 | 475 | 27426 | 119091 | 32366534 |
Graft versus host disease | 334.21 | 17.12 | 170 | 27731 | 10636 | 32474989 |
Acute graft versus host disease in skin | 285.26 | 17.12 | 120 | 27781 | 4837 | 32480788 |
Chronic graft versus host disease | 240.59 | 17.12 | 103 | 27798 | 4337 | 32481288 |
Venoocclusive disease | 215.09 | 17.12 | 83 | 27818 | 2663 | 32482962 |
Thrombotic microangiopathy | 208.60 | 17.12 | 119 | 27782 | 9363 | 32476262 |
Adenovirus infection | 206.08 | 17.12 | 94 | 27807 | 4610 | 32481015 |
Graft versus host disease in gastrointestinal tract | 200.31 | 17.12 | 84 | 27817 | 3357 | 32482268 |
Malignant transformation | 168.01 | 17.12 | 51 | 27850 | 772 | 32484853 |
Acute graft versus host disease in intestine | 167.35 | 17.12 | 68 | 27833 | 2505 | 32483120 |
Cytomegalovirus infection | 166.92 | 17.12 | 153 | 27748 | 25311 | 32460314 |
Second primary malignancy | 163.19 | 17.12 | 91 | 27810 | 6850 | 32478775 |
Graft versus host disease in skin | 160.96 | 17.12 | 73 | 27828 | 3531 | 32482094 |
Human herpesvirus 6 infection | 154.16 | 17.12 | 60 | 27841 | 1970 | 32483655 |
Off label use | 152.64 | 17.12 | 591 | 27310 | 305729 | 32179896 |
Osteonecrosis | 133.24 | 17.12 | 112 | 27789 | 16510 | 32469115 |
Product use in unapproved indication | 133.05 | 17.12 | 255 | 27646 | 86949 | 32398676 |
Neutropenia | 131.32 | 17.12 | 340 | 27561 | 141835 | 32343790 |
Chorioretinal atrophy | 130.93 | 17.12 | 27 | 27874 | 64 | 32485561 |
Multiple organ dysfunction syndrome | 114.89 | 17.12 | 211 | 27690 | 69643 | 32415982 |
Drug interaction | 110.37 | 17.12 | 26 | 27875 | 218159 | 32267466 |
Stem cell transplant | 108.68 | 17.12 | 48 | 27853 | 2179 | 32483446 |
Cytomegalovirus viraemia | 108.03 | 17.12 | 69 | 27832 | 6658 | 32478967 |
Epstein-Barr virus infection | 107.15 | 17.12 | 70 | 27831 | 7020 | 32478605 |
Plasma cell myeloma recurrent | 105.48 | 17.12 | 56 | 27845 | 3821 | 32481804 |
Pancytopenia | 103.14 | 17.12 | 236 | 27665 | 90999 | 32394626 |
Engraftment syndrome | 101.65 | 17.12 | 36 | 27865 | 902 | 32484723 |
Mucosal disorder | 99.92 | 17.12 | 42 | 27859 | 1687 | 32483938 |
Retinal pigment epitheliopathy | 93.79 | 17.12 | 25 | 27876 | 229 | 32485396 |
Sepsis | 92.61 | 17.12 | 323 | 27578 | 158511 | 32327114 |
Tooth extraction | 88.08 | 17.12 | 54 | 27847 | 4848 | 32480777 |
Epstein-Barr viraemia | 87.11 | 17.12 | 33 | 27868 | 1005 | 32484620 |
Aspergillus infection | 86.64 | 17.12 | 75 | 27826 | 11499 | 32474126 |
Thrombocytopenia | 85.93 | 17.12 | 301 | 27600 | 147998 | 32337627 |
Bronchopulmonary aspergillosis | 85.32 | 17.12 | 80 | 27821 | 13607 | 32472018 |
Pyrexia | 83.89 | 17.12 | 514 | 27387 | 319454 | 32166171 |
Haemophagocytic lymphohistiocytosis | 81.92 | 17.12 | 72 | 27829 | 11263 | 32474362 |
Headache | 81.92 | 17.12 | 33 | 27868 | 196164 | 32289461 |
Bone disorder | 80.47 | 17.12 | 58 | 27843 | 6822 | 32478803 |
Post transplant lymphoproliferative disorder | 79.48 | 17.12 | 54 | 27847 | 5780 | 32479845 |
Choroidal infarction | 79.24 | 17.12 | 18 | 27883 | 77 | 32485548 |
Acute graft versus host disease in liver | 78.19 | 17.12 | 33 | 27868 | 1339 | 32484286 |
Choroidal dystrophy | 77.86 | 17.12 | 16 | 27885 | 37 | 32485588 |
Basal cell carcinoma | 77.18 | 17.12 | 85 | 27816 | 17483 | 32468142 |
Dizziness | 75.68 | 17.12 | 43 | 27858 | 209575 | 32276050 |
Haematotoxicity | 74.44 | 17.12 | 55 | 27846 | 6721 | 32478904 |
Stomatitis | 74.42 | 17.12 | 128 | 27773 | 40101 | 32445524 |
Neuropathy peripheral | 73.90 | 17.12 | 187 | 27714 | 76795 | 32408830 |
Refractory anaemia with an excess of blasts | 72.58 | 17.12 | 23 | 27878 | 404 | 32485221 |
Chronic graft versus host disease in skin | 71.75 | 17.12 | 27 | 27874 | 807 | 32484818 |
Fatigue | 71.21 | 17.12 | 120 | 27781 | 350581 | 32135044 |
BK virus infection | 70.86 | 17.12 | 47 | 27854 | 4834 | 32480791 |
Progressive multifocal leukoencephalopathy | 69.80 | 17.12 | 61 | 27840 | 9470 | 32476155 |
Cystitis haemorrhagic | 66.50 | 17.12 | 46 | 27855 | 5068 | 32480557 |
Product dose omission issue | 66.03 | 17.12 | 6 | 27895 | 102569 | 32383056 |
Malaise | 65.85 | 17.12 | 35 | 27866 | 177103 | 32308522 |
Bacterial sepsis | 64.96 | 17.12 | 46 | 27855 | 5262 | 32480363 |
Blood stem cell transplant failure | 64.54 | 17.12 | 21 | 27880 | 403 | 32485222 |
Polyneuropathy | 63.41 | 17.12 | 67 | 27834 | 13148 | 32472477 |
Engraft failure | 62.46 | 17.12 | 21 | 27880 | 448 | 32485177 |
Arthralgia | 61.87 | 17.12 | 25 | 27876 | 148423 | 32337202 |
Dyspnoea | 60.42 | 17.12 | 139 | 27762 | 361906 | 32123719 |
Extraocular muscle disorder | 60.24 | 17.12 | 17 | 27884 | 196 | 32485429 |
Cytopenia | 59.24 | 17.12 | 57 | 27844 | 10007 | 32475618 |
Fall | 59.14 | 17.12 | 49 | 27852 | 196152 | 32289473 |
Aplasia | 57.87 | 17.12 | 40 | 27861 | 4402 | 32481223 |
Vitreous haemorrhage | 57.43 | 17.12 | 31 | 27870 | 2186 | 32483439 |
Parainfluenzae virus infection | 55.90 | 17.12 | 31 | 27870 | 2306 | 32483319 |
Diffuse large B-cell lymphoma | 53.77 | 17.12 | 50 | 27851 | 8412 | 32477213 |
Transplant failure | 53.61 | 17.12 | 32 | 27869 | 2736 | 32482889 |
Weight decreased | 52.38 | 17.12 | 39 | 27862 | 164779 | 32320846 |
Chest pain | 51.56 | 17.12 | 21 | 27880 | 124116 | 32361509 |
Acute lymphocytic leukaemia | 51.37 | 17.12 | 34 | 27867 | 3484 | 32482141 |
Overdose | 51.23 | 17.12 | 7 | 27894 | 87070 | 32398555 |
Apoptosis | 49.84 | 17.12 | 15 | 27886 | 220 | 32485405 |
Death | 49.55 | 17.12 | 166 | 27735 | 382351 | 32103274 |
Epstein-Barr virus associated lymphoproliferative disorder | 47.90 | 17.12 | 26 | 27875 | 1854 | 32483771 |
Septic shock | 47.87 | 17.12 | 149 | 27752 | 68840 | 32416785 |
Staphylococcal sepsis | 47.10 | 17.12 | 50 | 27851 | 9863 | 32475762 |
Prothrombin level increased | 46.87 | 17.12 | 13 | 27888 | 140 | 32485485 |
Posterior reversible encephalopathy syndrome | 46.74 | 17.12 | 49 | 27852 | 9527 | 32476098 |
Herpes zoster | 46.08 | 17.12 | 92 | 27809 | 32249 | 32453376 |
Bone debridement | 45.61 | 17.12 | 15 | 27886 | 298 | 32485327 |
Cytomegalovirus infection reactivation | 45.37 | 17.12 | 31 | 27870 | 3348 | 32482277 |
Bacterial infection | 45.35 | 17.12 | 58 | 27843 | 13948 | 32471677 |
Juvenile melanoma benign | 44.64 | 17.12 | 11 | 27890 | 71 | 32485554 |
Retinopathy proliferative | 44.00 | 17.12 | 11 | 27890 | 76 | 32485549 |
Cytomegalovirus test positive | 43.89 | 17.12 | 32 | 27869 | 3830 | 32481795 |
Transformation to acute myeloid leukaemia | 43.66 | 17.12 | 18 | 27883 | 688 | 32484937 |
Sequestrectomy | 43.59 | 17.12 | 15 | 27886 | 344 | 32485281 |
Neutropenic sepsis | 43.36 | 17.12 | 54 | 27847 | 12645 | 32472980 |
Bone sequestrum | 43.15 | 17.12 | 18 | 27883 | 709 | 32484916 |
Eyelid oedema | 43.11 | 17.12 | 36 | 27865 | 5253 | 32480372 |
Gastrointestinal mucosal disorder | 43.07 | 17.12 | 15 | 27886 | 357 | 32485268 |
Depression | 42.66 | 17.12 | 15 | 27886 | 97045 | 32388580 |
Bacteraemia | 42.03 | 17.12 | 63 | 27838 | 17570 | 32468055 |
Pneumonia cytomegaloviral | 41.65 | 17.12 | 28 | 27873 | 2944 | 32482681 |
Peripheral swelling | 41.39 | 17.12 | 5 | 27896 | 68340 | 32417285 |
Cerebral toxoplasmosis | 40.77 | 17.12 | 22 | 27879 | 1550 | 32484075 |
Rhabdomyolysis | 40.54 | 17.12 | 5 | 27896 | 67260 | 32418365 |
Debridement | 40.41 | 17.12 | 19 | 27882 | 998 | 32484627 |
Acute respiratory distress syndrome | 39.84 | 17.12 | 75 | 27826 | 25178 | 32460447 |
Blood pressure increased | 38.97 | 17.12 | 10 | 27891 | 79344 | 32406281 |
Squamous cell carcinoma of skin | 38.81 | 17.12 | 45 | 27856 | 9781 | 32475844 |
JC virus infection | 38.75 | 17.12 | 23 | 27878 | 1946 | 32483679 |
Anxiety | 38.63 | 17.12 | 17 | 27884 | 95988 | 32389637 |
Cerebrovascular accident | 38.52 | 17.12 | 13 | 27888 | 86307 | 32399318 |
Myocardial infarction | 38.31 | 17.12 | 31 | 27870 | 125645 | 32359980 |
Ameloblastoma | 38.28 | 17.12 | 10 | 27891 | 84 | 32485541 |
Asthenia | 38.12 | 17.12 | 92 | 27809 | 235852 | 32249773 |
Bone marrow failure | 38.05 | 17.12 | 82 | 27819 | 30322 | 32455303 |
Myalgia | 36.65 | 17.12 | 12 | 27889 | 81218 | 32404407 |
Systemic candida | 36.55 | 17.12 | 26 | 27875 | 2995 | 32482630 |
Drug hypersensitivity | 36.53 | 17.12 | 9 | 27892 | 73391 | 32412234 |
Idiopathic pneumonia syndrome | 36.41 | 17.12 | 12 | 27889 | 240 | 32485385 |
Somnolence | 36.39 | 17.12 | 22 | 27879 | 103775 | 32381850 |
Eyelid rash | 36.27 | 17.12 | 8 | 27893 | 29 | 32485596 |
Meningomyelitis herpes | 36.06 | 17.12 | 8 | 27893 | 30 | 32485595 |
Viral haemorrhagic cystitis | 35.72 | 17.12 | 17 | 27884 | 918 | 32484707 |
Chorioretinal disorder | 35.65 | 17.12 | 8 | 27893 | 32 | 32485593 |
Hepatitis B | 35.60 | 17.12 | 35 | 27866 | 6306 | 32479319 |
Hepatic infection fungal | 35.27 | 17.12 | 11 | 27890 | 183 | 32485442 |
Hyperhidrosis | 34.89 | 17.12 | 9 | 27892 | 71159 | 32414466 |
Iris atrophy | 34.63 | 17.12 | 9 | 27892 | 74 | 32485551 |
Autoimmune haemolytic anaemia | 34.06 | 17.12 | 29 | 27872 | 4345 | 32481280 |
Lymphopenia | 33.53 | 17.12 | 51 | 27850 | 14405 | 32471220 |
Metastases to retroperitoneum | 33.24 | 17.12 | 11 | 27890 | 223 | 32485402 |
Refractory cytopenia with multilineage dysplasia | 33.08 | 17.12 | 10 | 27891 | 149 | 32485476 |
Bone sarcoma | 32.96 | 17.12 | 9 | 27892 | 91 | 32485534 |
Feeling abnormal | 32.95 | 17.12 | 6 | 27895 | 60417 | 32425208 |
Epstein-Barr virus infection reactivation | 31.73 | 17.12 | 13 | 27888 | 489 | 32485136 |
Ureaplasma infection | 30.97 | 17.12 | 10 | 27891 | 187 | 32485438 |
Meningoencephalitis herpetic | 30.97 | 17.12 | 15 | 27886 | 842 | 32484783 |
Neutropenic colitis | 30.70 | 17.12 | 22 | 27879 | 2563 | 32483062 |
Eye excision | 30.26 | 17.12 | 7 | 27894 | 33 | 32485592 |
Pruritus | 29.91 | 17.12 | 40 | 27861 | 128662 | 32356963 |
Bradycardia | 29.86 | 17.12 | 12 | 27889 | 71550 | 32414075 |
Metastases to muscle | 29.84 | 17.12 | 10 | 27891 | 211 | 32485414 |
Autoimmune neutropenia | 29.80 | 17.12 | 11 | 27890 | 311 | 32485314 |
Pain | 29.59 | 17.12 | 74 | 27827 | 187482 | 32298143 |
Human herpesvirus 6 encephalitis | 29.58 | 17.12 | 10 | 27891 | 217 | 32485408 |
Hepatic vein occlusion | 29.48 | 17.12 | 9 | 27892 | 139 | 32485486 |
Acute lymphocytic leukaemia recurrent | 29.47 | 17.12 | 23 | 27878 | 3049 | 32482576 |
Osteomyelitis | 29.22 | 17.12 | 50 | 27851 | 15583 | 32470042 |
Coronary artery disease | 29.21 | 17.12 | 4 | 27897 | 49702 | 32435923 |
B precursor type acute leukaemia | 28.95 | 17.12 | 9 | 27892 | 148 | 32485477 |
Plasmacytoma | 28.93 | 17.12 | 24 | 27877 | 3469 | 32482156 |
Chronic graft versus host disease in intestine | 28.75 | 17.12 | 10 | 27891 | 237 | 32485388 |
Osteosarcoma | 28.67 | 17.12 | 10 | 27891 | 239 | 32485386 |
Candida sepsis | 28.45 | 17.12 | 16 | 27885 | 1223 | 32484402 |
Urticaria | 28.35 | 17.12 | 8 | 27893 | 59606 | 32426019 |
Metapneumovirus infection | 28.30 | 17.12 | 13 | 27888 | 647 | 32484978 |
Human herpesvirus 8 infection | 28.21 | 17.12 | 14 | 27887 | 829 | 32484796 |
Carbamoyl phosphate synthetase deficiency | 28.07 | 17.12 | 6 | 27895 | 18 | 32485607 |
Pneumonia respiratory syncytial viral | 27.91 | 17.12 | 14 | 27887 | 848 | 32484777 |
Febrile bone marrow aplasia | 27.48 | 17.12 | 35 | 27866 | 8380 | 32477245 |
Neoplasm skin | 27.01 | 17.12 | 12 | 27889 | 552 | 32485073 |
Short stature | 26.67 | 17.12 | 7 | 27894 | 60 | 32485565 |
Pneumonia | 26.64 | 17.12 | 440 | 27461 | 354812 | 32130813 |
Infection | 26.53 | 17.12 | 143 | 27758 | 84572 | 32401053 |
Leukaemia | 26.19 | 17.12 | 24 | 27877 | 3962 | 32481663 |
Obliterative bronchiolitis | 25.95 | 17.12 | 15 | 27886 | 1208 | 32484417 |
Neoplasm recurrence | 25.65 | 17.12 | 18 | 27883 | 2029 | 32483596 |
Inflammatory myofibroblastic tumour | 25.60 | 17.12 | 8 | 27893 | 134 | 32485491 |
Blood glucose increased | 25.54 | 17.12 | 12 | 27889 | 65229 | 32420396 |
Confusional state | 25.36 | 17.12 | 53 | 27848 | 143062 | 32342563 |
Klebsiella sepsis | 25.19 | 17.12 | 17 | 27884 | 1799 | 32483826 |
Stenotrophomonas infection | 25.15 | 17.12 | 17 | 27884 | 1803 | 32483822 |
Hepatitis B reactivation | 25.10 | 17.12 | 22 | 27879 | 3427 | 32482198 |
Atrophy of globe | 25.02 | 17.12 | 6 | 27895 | 34 | 32485591 |
Enteritis | 24.98 | 17.12 | 31 | 27870 | 7230 | 32478395 |
Expanded disability status scale score increased | 24.88 | 17.12 | 9 | 27892 | 240 | 32485385 |
Adenocarcinoma of colon | 24.88 | 17.12 | 22 | 27879 | 3467 | 32482158 |
Asthma | 24.85 | 17.12 | 4 | 27897 | 44061 | 32441564 |
Metastases to spleen | 24.77 | 17.12 | 10 | 27891 | 362 | 32485263 |
Pain in extremity | 24.65 | 17.12 | 40 | 27861 | 118861 | 32366764 |
Hypoglycaemia | 24.59 | 17.12 | 8 | 27893 | 54374 | 32431251 |
Nasopharyngitis | 24.56 | 17.12 | 12 | 27889 | 63775 | 32421850 |
Product use issue | 24.55 | 17.12 | 100 | 27801 | 52677 | 32432948 |
Premature ageing | 24.55 | 17.12 | 7 | 27894 | 84 | 32485541 |
Joint swelling | 24.49 | 17.12 | 7 | 27894 | 51728 | 32433897 |
Graft versus host disease in liver | 24.46 | 17.12 | 14 | 27887 | 1107 | 32484518 |
Capillary leak syndrome | 24.30 | 17.12 | 17 | 27884 | 1906 | 32483719 |
Gait disturbance | 24.28 | 17.12 | 20 | 27881 | 80388 | 32405237 |
Staphylococcal bacteraemia | 24.26 | 17.12 | 31 | 27870 | 7445 | 32478180 |
Purulent discharge | 23.72 | 17.12 | 20 | 27881 | 2956 | 32482669 |
Myelitis | 23.63 | 17.12 | 12 | 27889 | 746 | 32484879 |
Balance disorder | 23.61 | 17.12 | 3 | 27898 | 39456 | 32446169 |
Hyperbilirubinaemia | 23.54 | 17.12 | 49 | 27852 | 17681 | 32467944 |
Insomnia | 23.50 | 17.12 | 31 | 27870 | 100317 | 32385308 |
Chest discomfort | 23.40 | 17.12 | 7 | 27894 | 50223 | 32435402 |
Respiratory syncytial virus infection | 23.18 | 17.12 | 22 | 27879 | 3796 | 32481829 |
Iris neovascularisation | 22.92 | 17.12 | 5 | 27896 | 17 | 32485608 |
Bone marrow transplant rejection | 22.60 | 17.12 | 8 | 27893 | 200 | 32485425 |
Hospitalisation | 22.50 | 17.12 | 7 | 27894 | 48964 | 32436661 |
Myositis | 22.42 | 17.12 | 37 | 27864 | 11198 | 32474427 |
Delayed engraftment | 22.41 | 17.12 | 7 | 27894 | 117 | 32485508 |
Chronic obstructive pulmonary disease | 22.34 | 17.12 | 7 | 27894 | 48746 | 32436879 |
Pulmonary alveolar haemorrhage | 22.25 | 17.12 | 29 | 27872 | 7100 | 32478525 |
Cytogenetic abnormality | 22.05 | 17.12 | 12 | 27889 | 860 | 32484765 |
B-cell lymphoma recurrent | 22.04 | 17.12 | 11 | 27890 | 659 | 32484966 |
Tooth impacted | 21.95 | 17.12 | 6 | 27895 | 61 | 32485564 |
Papilloma | 21.93 | 17.12 | 7 | 27894 | 126 | 32485499 |
Complications of bone marrow transplant | 21.92 | 17.12 | 8 | 27893 | 219 | 32485406 |
Therapy partial responder | 21.90 | 17.12 | 24 | 27877 | 4906 | 32480719 |
Blood creatine phosphokinase increased | 21.81 | 17.12 | 6 | 27895 | 45470 | 32440155 |
Pulmonary haemorrhage | 21.77 | 17.12 | 34 | 27867 | 9823 | 32475802 |
Metastases to bone marrow | 21.53 | 17.12 | 10 | 27891 | 511 | 32485114 |
Heterochromia iridis | 21.48 | 17.12 | 4 | 27897 | 4 | 32485621 |
Tremor | 21.27 | 17.12 | 23 | 27878 | 81254 | 32404371 |
Musculoskeletal stiffness | 21.19 | 17.12 | 4 | 27897 | 39260 | 32446365 |
Gingival erythema | 21.15 | 17.12 | 7 | 27894 | 142 | 32485483 |
Condition aggravated | 21.13 | 17.12 | 66 | 27835 | 155595 | 32330030 |
Mycobacterium kansasii infection | 20.89 | 17.12 | 8 | 27893 | 251 | 32485374 |
Vision blurred | 20.87 | 17.12 | 6 | 27895 | 44180 | 32441445 |
Laryngeal cancer metastatic | 20.67 | 17.12 | 6 | 27895 | 77 | 32485548 |
Adenocarcinoma gastric | 20.62 | 17.12 | 13 | 27888 | 1225 | 32484400 |
Pneumonia mycoplasmal | 20.50 | 17.12 | 10 | 27891 | 570 | 32485055 |
Neurotoxicity | 20.42 | 17.12 | 42 | 27859 | 15028 | 32470597 |
Viraemia | 20.38 | 17.12 | 13 | 27888 | 1250 | 32484375 |
Jaw operation | 20.37 | 17.12 | 8 | 27893 | 269 | 32485356 |
Hyperkalaemia | 20.26 | 17.12 | 18 | 27883 | 69732 | 32415893 |
Myelosuppression | 20.08 | 17.12 | 36 | 27865 | 11640 | 32473985 |
Herpes zoster meningoencephalitis | 20.07 | 17.12 | 8 | 27893 | 280 | 32485345 |
Exophthalmos | 20.04 | 17.12 | 10 | 27891 | 599 | 32485026 |
Retinoblastoma | 19.94 | 17.12 | 5 | 27896 | 35 | 32485590 |
Retinal toxicity | 19.90 | 17.12 | 9 | 27892 | 432 | 32485193 |
Bone lesion | 19.88 | 17.12 | 18 | 27883 | 2925 | 32482700 |
Genotoxicity | 19.82 | 17.12 | 5 | 27896 | 36 | 32485589 |
Acute myeloid leukaemia recurrent | 19.71 | 17.12 | 15 | 27886 | 1915 | 32483710 |
Inflammatory pseudotumour | 19.70 | 17.12 | 5 | 27896 | 37 | 32485588 |
Amyloidosis | 19.67 | 17.12 | 16 | 27885 | 2250 | 32483375 |
Colitis | 19.65 | 17.12 | 69 | 27832 | 33882 | 32451743 |
Electrocardiogram QT prolonged | 19.45 | 17.12 | 5 | 27896 | 39636 | 32445989 |
VIth nerve paresis | 19.36 | 17.12 | 5 | 27896 | 40 | 32485585 |
Transplantation associated food allergy | 19.25 | 17.12 | 5 | 27896 | 41 | 32485584 |
Autoimmune pancytopenia | 19.01 | 17.12 | 6 | 27895 | 104 | 32485521 |
Agitation | 18.86 | 17.12 | 13 | 27888 | 57223 | 32428402 |
Activated partial thromboplastin time shortened | 18.74 | 17.12 | 9 | 27892 | 496 | 32485129 |
Device related infection | 18.69 | 17.12 | 45 | 27856 | 17888 | 32467737 |
Injection site pain | 18.64 | 17.12 | 3 | 27898 | 33055 | 32452570 |
Disease recurrence | 18.59 | 17.12 | 42 | 27859 | 16022 | 32469603 |
Plasma cell leukaemia | 18.54 | 17.12 | 11 | 27890 | 930 | 32484695 |
Osteolysis | 18.48 | 17.12 | 14 | 27887 | 1775 | 32483850 |
Cytomegalovirus gastroenteritis | 18.48 | 17.12 | 7 | 27894 | 213 | 32485412 |
Cystitis viral | 18.45 | 17.12 | 9 | 27892 | 513 | 32485112 |
Streptococcal bacteraemia | 18.41 | 17.12 | 14 | 27887 | 1786 | 32483839 |
Muscle spasms | 18.34 | 17.12 | 20 | 27881 | 70398 | 32415227 |
Retinal artery stenosis | 18.19 | 17.12 | 3 | 27898 | 0 | 32485625 |
Gastrointestinal toxicity | 18.17 | 17.12 | 15 | 27886 | 2154 | 32483471 |
Cardiac failure congestive | 18.09 | 17.12 | 28 | 27873 | 84824 | 32400801 |
American trypanosomiasis | 18.00 | 17.12 | 7 | 27894 | 229 | 32485396 |
International normalised ratio increased | 17.73 | 17.12 | 10 | 27891 | 49025 | 32436600 |
Loss of therapeutic response | 17.59 | 17.12 | 7 | 27894 | 244 | 32485381 |
Adenoviral hepatitis | 17.53 | 17.12 | 7 | 27894 | 246 | 32485379 |
Gastrointestinal injury | 17.46 | 17.12 | 8 | 27893 | 396 | 32485229 |
Disseminated varicella zoster virus infection | 17.46 | 17.12 | 11 | 27890 | 1036 | 32484589 |
Adenosquamous cell lung cancer | 17.44 | 17.12 | 4 | 27897 | 18 | 32485607 |
Back pain | 17.34 | 17.12 | 44 | 27857 | 111009 | 32374616 |
Blast crisis in myelogenous leukaemia | 17.32 | 17.12 | 9 | 27892 | 587 | 32485038 |
Pneumonia fungal | 17.24 | 17.12 | 24 | 27877 | 6256 | 32479369 |
Flushing | 17.16 | 17.12 | 3 | 27898 | 31124 | 32454501 |
Source | Code | Description |
---|---|---|
ATC | L01AA03 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS ALKYLATING AGENTS Nitrogen mustard analogues |
FDA MoA | N0000000236 | Alkylating Activity |
FDA EPC | N0000175558 | Alkylating Drug |
MeSH PA | D000477 | Alkylating Agents |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D018906 | Antineoplastic Agents, Alkylating |
MeSH PA | D007155 | Immunologic Factors |
MeSH PA | D007166 | Immunosuppressive Agents |
MeSH PA | D019653 | Myeloablative Agonists |
MeSH PA | D009676 | Noxae |
CHEBI has role | CHEBI:35610 | cytostatic |
CHEBI has role | CHEBI:35705 | immunosuppressant |
CHEBI has role | CHEBI:50903 | cancerogene |
CHEBI has role | CHEBI:88188 | allergenic drug |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Multiple myeloma | indication | 109989006 | DOID:9538 |
Malignant tumor of ovary | indication | 363443007 | DOID:2394 |
Allogeneic bone marrow transplantation | off-label use | 58390007 | |
Diffuse non-Hodgkin's lymphoma, large cell | off-label use | 109969005 | |
Acute hemorrhage | contraindication | 8573003 | |
Vasculitis | contraindication | 31996006 | DOID:865 |
Fibrosis of lung | contraindication | 51615001 | DOID:3770 |
Portal vein obstruction | contraindication | 57348003 | |
Hemolytic anemia | contraindication | 61261009 | DOID:583 |
Acute infectious disease | contraindication | 63171007 | |
Interstitial pneumonia | contraindication | 64667001 | |
Leukopenia | contraindication | 84828003 | DOID:615 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Radiation oncology AND/OR radiotherapy | contraindication | 108290001 | |
Liver function tests abnormal | contraindication | 166603001 | |
Drug-induced hepatitis | contraindication | 235876009 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Bone marrow depression | contraindication | 307762000 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Granulocytopenic disorder | contraindication | 417672002 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.27 | acidic |
pKa2 | 9.25 | Basic |
pKa3 | 4.94 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
EQ 50MG BASE/VIAL | EVOMELA | ACROTECH | N207155 | March 10, 2016 | RX | POWDER | INTRAVENOUS | 10940128 | June 14, 2030 | FOR HIGH-DOSE CONDITIONING TREATMENT PRIOR TO HEMATOPOIETIC PROGENITOR (STEM) CELL TRANSPLANTATION IN PATIENTS WITH MULTIPLE MYELOMA |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
---|---|---|---|---|---|---|---|---|---|
EQ 50MG BASE/VIAL | EVOMELA | ACROTECH | N207155 | March 10, 2016 | RX | POWDER | INTRAVENOUS | March 10, 2023 | FOR HIGH-DOSE CONDITIONING TREATMENT PRIOR TO HEMATOPOIETIC PROGENITOR (STEM) CELL TRANSPLANTATION IN PATIENTS WITH MULTIPLE MYELOMA |
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
L-type amino acid transporter 1 | Transporter | Ki | 4.26 | CHEMBL |
ID | Source |
---|---|
4020558 | VUID |
N0000022818 | NUI |
D00369 | KEGG_DRUG |
3223-07-2 | SECONDARY_CAS_RN |
4018763 | VANDF |
4020558 | VANDF |
C0025241 | UMLSCUI |
CHEBI:28876 | CHEBI |
CHEMBL852 | ChEMBL_ID |
CHEMBL250892 | ChEMBL_ID |
CHEMBL1200863 | ChEMBL_ID |
DB01042 | DRUGBANK_ID |
D008558 | MESH_DESCRIPTOR_UI |
460612 | PUBCHEM_CID |
7620 | IUPHAR_LIGAND_ID |
745 | INN_ID |
Q41OR9510P | UNII |
151325 | RXNORM |
167596 | MMSL |
1789 | MMSL |
31570 | MMSL |
5038 | MMSL |
d00287 | MMSL |
002633 | NDDF |
004144 | NDDF |
387297002 | SNOMEDCT_US |
426388000 | SNOMEDCT_US |
544002 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Melphalan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 47781-200 | TABLET | 2 mg | ORAL | ANDA | 22 sections |
ALKERAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52609-0001 | TABLET, FILM COATED | 2 mg | ORAL | NDA | 24 sections |
EVOMELA | Human Prescription Drug Label | 1 | 68152-109 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 50 mg | INTRAVENOUS | NDA | 26 sections |
EVOMELA | Human Prescription Drug Label | 1 | 72893-001 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 50 mg | INTRAVENOUS | NDA | 26 sections |