trofosfamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antineoplastic, alkylating agents, (beta-chloroethyl)amine derivatives 2766 22089-22-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • trofosfamide
  • ixoten
  • trifosfamide
  • trilofosfamida
  • trilophosphamide
  • triphosphamide
  • trisfosfamide
  • trofosfamid
  • trophosphamid
  • trophosphamide
cyclophosphamide analog; structure
  • Molecular weight: 323.58
  • Formula: C9H18Cl3N2O2P
  • CLOGP: 1.18
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 32.78
  • ALOGS: -1.43
  • ROTB: 7

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01AA07 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ALKYLATING AGENTS
Nitrogen mustard analogues
MeSH PA D000477 Alkylating Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018906 Antineoplastic Agents, Alkylating
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D009153 Mutagens
MeSH PA D009676 Noxae

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07252 KEGG_DRUG
C0077375 UMLSCUI
CHEBI:135381 CHEBI
CHEMBL462019 ChEMBL_ID
DB12902 DRUGBANK_ID
C003726 MESH_SUPPLEMENTAL_RECORD_UI
65702 PUBCHEM_CID
2866 INN_ID
H64JRU6GJ0 UNII
38865 RXNORM
007090 NDDF
1156222009 SNOMEDCT_US

Pharmaceutical products:

None